A Comparative Analysis Of Cultural Preservation Focused Land-Use Regulations Within The Gullah Geechee Cultural Heritage Corridor Of South Carolina, Nolly C. Swan

All Theses

This thesis is an analysis of three land-use regulations: conservation easements and fee simple ownership by conservation land trust, an area specific zoning overlay, and a town-wide ordinance, all aimed at protecting cultural heritage on different islands within the Gullah Geechee Cultural Heritage Corridor (GGCHC) of South Carolina: Edisto Island, St. Helena Island, and Hilton Head Island. The lower sea islands of South Carolina have a unique natural and cultural landscape under threat of loss, both tangible and intangible heritage is vulnerable. This study provides an individual and comparative analysis of goals for land-use regulations. The purpose statements of the …

Quantifying The Transformation Of The Built Environment As A Result Of Cooper River Bridge Construction In Charleston, South Carolina, Catherine Claire Jackson

All Theses

The demolition of historically undervalued vernacular architecture for the construction of transportation projects has created a large-scale, cumulative loss of architectural heritage nationwide. This thesis quantifies the architectural loss caused by the construction of the series of Cooper River bridges in peninsular Charleston and Mount Pleasant. This study assesses the transformation of the built environment as a result of each bridge’s construction by determining the quantity of architectural loss, identifying forms and materials of architectural loss, and differentiating the effects of bridge construction on the more rural Mount Pleasant side compared to the urban peninsular Charleston side. Also assessed in …

Speaking Up: A Courage Framework Of Bipoc Voices In The Workplace, Aishah Khan

All Theses

Despite the many beneficial outcomes of voice in the workplace, employers and employees do not often utilize it to its full potential, particularly those from historically marginalized groups. Past literature has examined the many ways in which the experience of minority-group members differs from that of majority-group members; however, scarce work has been done exploring the “mental calculus” that those from marginalized groups go through when deciding whether to advocate for themselves or others at work. To provide insight into this specific experience, I manipulated representation and context in a novel fashion – and examined if and how safety, risk, …

A Qualitative Analysis Of Graffiti Inscriptions At Ecclesiastical Sites In The South Carolina Lowcountry, Hannah Truman

All Theses

The study of graffiti has become a multi-disciplinary study. Historical and modern forms of graffiti offer a unique perspective on the connection people have with religious sites over the span of three hundred years. Within South Carolina, the establishment of twenty-five churches throughout the Lowcountry from 1706 to 1775 offers an understanding of people’s connection to spaces from the beginning of South Carolina’s establishment to the present day. Their beliefs are reflected throughout the space of the building as congregations have left their imprint.

In order to understand the relationship of people to the site over time, various methods were …

Thymosin Beta-4: A Novel Treatment For Acanthamoeba Keratitis, Victoria A. Murphey

All Theses

Acanthamoeba keratitis (AK) is a severe corneal infection caused by the free-living amoeba, Acanthamoeba. Both stages of its life cycle (trophozoite and cyst) cause infection, primarily in contact lens wearers. It is often misdiagnosed, leading to delayed treatment and poor clinical outcomes. Current treatment options for AK rely on anti-amoebic agents that are toxic to corneal epithelial cells. Further, no single drug can eliminate both forms of the amoeba. Approximately 30% of all AK infections require a corneal transplant.

Thymosin beta-4 (Tβ4) is a G-actin binding protein synthesized in almost all human cells, including corneal epithelial cells. Tβ4 exhibits …

African Sleeping Sickness: From Basic Biology To Future Directions, Riddhi R. Patel

All Theses

African Sleeping Sickness is a Neglected Tropical Disease (NTD) which poses a significant health risk to impoverished populations in 36 Sub-Saharan African countries. It is a devastating disease caused by the protozoan parasite Trypanosoma brucei, which is transmitted to mammals via the bite of infected tsetse flies. The disease manifests in two stages: the hemolymphatic stage and the meningoencephalitic stage. In the latter stage, it invades the Central Nervous System (CNS) and can be fatal if left untreated. It is caused by morphologically indistinguishable species of Trypanosoma brucei in both humans and animals, where in humans it is known as …

Evaluating The Role Of Electrostatic Forces In The Adsorption Of Perfluoroalkyl Substances To Granular Activated Carbon, Thomas A. Mccall

All Theses

In response to new drinking water regulations announced by the EPA in 2024, many municipalities will need to monitor concentrations and implement new treatments to address PFAS, a class of anthropogenic organic contaminants. A leading technology for this application is GAC adsorption due to its familiarity and availability. The adsorption of four PFAS species (PFBA, PFBS, PFOA and PFOS) to Calgon Filtrasorb400 (F400) was evaluated for a range of pH and ionic strength conditions to investigate the role of electrostatic interactions in adsorption capacity. These PFAS are all strong acids, so pH was used as a control for GAC surface …

Graph Based Deep Reinforcement Learning Aided By Transformers For Multi-Agent Cooperation, Michael S. Elrod

All Theses

Mission planning for a fleet of cooperative autonomous drones in applications that involve serving distributed target points, such as disaster response, environmental monitoring, and surveil- lance, is challenging, especially under partial observability, limited communication range, and uncertain environments. Traditional path-planning algorithms struggle in these scenarios, particu- larly when prior information is not available. To address these challenges, I propose an innovative framework that integrates Graph Neural Networks (GNNs), Deep Reinforcement Learning (DRL), and transformer-based mechanisms for enhanced multi-agent coordination and collective task ex- ecution. My approach leverages GNNs to model agent-agent and agent-goal interactions through adaptive graph construction, enabling efficient …

Blockchain-Integrated Version Control For Secure And Transparent Software Supply Chains, Iwinosa W. Aideyan

All Theses

The software supply chain encompasses all stages of software development and delivery from initial coding and version control to integration and deployment. As development environments become increasingly distributed and reliant on external dependencies, ensuring the integrity, auditability, and consistency of code changes has become a pressing challenge. Traditional version control systems like Git, while effective for collaboration and tracking revisions, do not inherently provide tamper-evident commit histories. Features such as history rewriting (e.g., git rebase, git push --force) can be exploited to manipulate commit logs without detection, posing risks in security-sensitive domains. This thesis proposes a blockchain-integrated version control framework …

Unsettling Femininity In Ottessa Moshfegh’S My Year Of Rest And Relaxation, Audrianna Witcher

All Theses

This thesis covers how Ottessa Moshfegh’s My Year of Rest and Relaxation critiques traditional understandings of femininity and the inadequacy of neoliberal feminism to address the systemic issues that women face. Using Lauren Berlant’s concept of femininity as a genre, this thesis traces how Moshfegh implements disgust and abjection to reject mandates of cleanliness and emotional labor that are central to traditional femininity. Moshfegh also utilizes disgust and the narrator’s attempt at a year-long sleep to resist the ideals of productivity and self-care that are central to neoliberal feminism. In employing these affects, Moshfegh resists the social structures that exploit …

“Raise Your Keffiyeh:” Headdress As A Lens For Understanding The Arab Revolt In Mandatory Palestine, 1936-1939, Kathryn Kf Butler

All Theses

In the fall of 1938, approaching the apex of the most intensive period of violence during the Arab Revolt against the British government in Mandatory Palestine (1936-1939), a seemingly unassuming change occurred for Arab men in cities throughout the region: they donned a new headdress. Sartorial shifts in the early post-Ottoman period were not unique to Palestine. During the Interwar period, changes in male headgear occurred throughout the greater Middle East in Turkey, Afghanistan, Iran, Syria and Iraq, to name a few. These transformations of dress signaled a shift in something either societal or political and oftentimes both. I argue …

"All The Songs I Stole": Ballad Collection And The Conditions Of Collective-Making In Johnny Cash's Prison Concert-Albums, Camryn J. Bruce

All Theses

In the mid-to-late twentieth century, singer-songwriter Johnny Cash recorded and released three live prison concert-albums composed of many ballads and songs drawing upon a ballad tradition. I question the degree to which these albums, as performed and commercialized ballad collections, create realities of unity between Cash and his audiences. Reviewing three ballads for their aspects of balladry and performance, this thesis finds that Cash’s albums echo and make echoes of isolating conditions and possible collectivities, demonstrating a fragility of “folk” in the shifting scenes of music and prison.

Connecting With Millennials: A Guide For Donor Engagement, Sydney A. Hopkins

All Theses

Millennials are emerging as a vital donor demographic, yet many resource-limited nonprofits, including Clemson Community Care (CCC), struggle to effectively engage this generation. This applied thesis project investigates how CCC can build meaningful connections with millennial donors by exploring nonprofit awareness, donor motivations, communication expectations, content preferences, and common barriers to giving. Using qualitative data gathered from two focus groups of millennial participants, this study reveals that millennials represent a diverse and distinct audience with unique expectations for nonprofit communication. Grounded in public relations theories of stewardship and organization-public relationships (OPR), the research highlights the importance of flexibility and autonomy …

Defining Fidelity For Tradespace Application, Aditya Agrawal

All Theses

This research proposes a definition of tradespace fidelity and presents a study on its effectiveness in the tradespace. Tradespace exploration helps evaluate various design options, allowing engineers to make informed decisions in early design stages. Fidelity generally refers to how closely a model approximates reality. However, the definition of fidelity has been inconsistently defined and interpreted in various contexts concerning particular problems. In some cases, it is a measure of accuracy; in others, information; in another, uncertainty; and in others, computational complexity. Fidelity is poorly and inconsistently defined in the literature. In general, higher fidelity models tend to be more …

Investigating Psychological Moderators Of The Effect Of A Slow-Paced Breathing Intervention On Decision-Making Performance, Anthony Alvarado

All Theses

Decision-making is a ubiquitous cognitive process that individuals engage in constantly—some decisions are inconsequential while others can have drastic implications. Identifying ways to improve decision-making, therefore, has potential to have lasting positive effects. One potential approach is slow-paced breathing interventions. While such interventions have shown promise for improving certain aspects of cognition, such as working memory, few studies have examined the effect of slow-paced breathing on decision-making performance. The current study sought to examine the effect of a brief slow-paced breathing intervention on performance on the Iowa Gambling Task (IGT), a reward-based decision-making task. Potential moderating variables such as stress, …

Tiktok Made Me Do It: #75hard, Alexis Lamere

All Theses

TikTok is one of many social media platforms that distribute entertainment videos to its users based on an interactive algorithm. It has an influential impact on the information individuals are exposed to, especially when it is a trending topic. These trending TikTok videos reach millions of viewers; one popular trend on this app is #75Hard. #75Hard is a restrictive fitness program emphasizing mental toughness, self-discipline, and strict diet and exercise routines. However, popular trends like this one can perpetuate unrealistic and unattainable goals that put people at risk for negative outcomes such as body dissatisfaction and disordered eating. The present …

Divergence-Free Smoothed Particle Hydrodynamics In A Stream Digital Twin, Austin Hartley

All Theses

Digital Twins (DT) are being explored by the South Carolina (SC) water community to simulate how SC streams will flow at various water levels. Currently, a DT called Gilligan simulates these streams utilizing weakly-incompressible Smoothed Particle Hydrodynamics (SPH). This method does not strictly enforce incompressibility, which leads to unrealistic water flows and unwanted visual artifacts that require post-processing effects to hide. To address these problems and simulate more realistic water flows, the Gilligan stream logic is updated and a state-of-the-art SPH method that enforces incompressibility—Divergence-Free SPH (DFSPH)—is implemented within the Gilligan framework. DFSPH is able to make use of two …

Normative Variability In Retinal Nerve Fiber Layer Thickness: Does It Matter Where The Peaks Are?, Sowjanya Gowrisankaran, Ashkan Abbasi, Xubo Song, Joel Schuman, Gadi Wollstein, Bhavna Antony, Hiroshi Ishikawa

Wills Eye Hospital Papers

PURPOSE: Retinal nerve fiber layer thickness (RNFLT), a glaucoma biomarker, has a wide normative range affecting its sensitivity and specificity for abnormality detection. The interindividual RNFLT peak location variability contribution to this wide normative range has not been directly evaluated. The purpose of this study is to assess the effect of RNFLT peak normalization (PN) on normative variability.

METHODS: Circumpapillary RNFLT profiles at 1.7 mm radius from the optic nerve head (ONH) were re-sampled from optical coherence tomography (OCT) volumes (Cirrus HD-OCT, 200 × 200) obtained from one eye of 83 healthy individuals. Fovea-ONH axis (FOA) was calculated from corresponding …

Strategies For Enhancing Thermal Comfort In Bus Stops Through Sustainable Design And Material Selection, Amany G. Micheal Prof., Mirette Asser, Noureldin Awad

Architectural Engineering

Global warming is an undeniable reality, necessitating innovative solutions to enhance thermal comfort while minimizing environmental impact, and avoiding the rapid reliance on fossil fuel based approaches. This research specifically addresses the challenge of improving thermal comfort at bus stops in Egypt’s arid climate, where high temperatures, intense solar radiation, and wind cause significant discomfort for passengers waiting for public transportation. The study focuses on implementing passive design strategies, including shading devices and ventilation techniques, tailored to the region’s wind patterns and solar conditions. Additionally, this research introduces a novel, sustainable composite material made from sugarcane bagasse and epoxy resin, …

In This Issueoriginal Articlesystematic Reviewsscoping Review

Saudi Medical Journal

No abstract provided.

Breast Cancer Incidence After Hormonal Treatment For Infertility: A Meta-Analysis Of Population-Based Studies, Amal Y. Zaman, Lama S. Alrefai, Dorar F. Alharbi, Rahaf A. Khurmi, Leen M. Abuanq, Ajyal A. Aljohani, Ibrahim M. Dighriri, Nada Elnugomi

Saudi Medical Journal

ABSTRACT Objectives: To comprehensively understand the relationship between infertility medications and the risk of breast cancer (BC) in females. Methods: Relevant literature search using different databases (PubMed, The Cochrane Library, Embase, Scopus, and Web of Sciences) following preferred reporting items for systematic reviews and meta-analyses guidelines was carried out from 2003-2023. Population-based studies comparing the incidence of BC after hormonal fertility treatment and a control group were included. In addition, random and fixed effect models were used to carry out meta-analyses. Results: A total of 15 studies involving 92,555 women were included in this review. The pooled analysis using risk …

Pocket-Creation Method Versus Conventional Method Of Endoscopic Submucosal Dissection For Early Gastric Cancer: A Systematic Review And Meta-Analysis, Min-Min Song, Feng-Bing Wang, Jian-Lin Yang, Hai-Yan Zhang, Tai-Ping Wang

Saudi Medical Journal

ABSTRACT Objectives: To compare the efficacy and safety between 2 endoscopic surgical approaches for early gastric cancer: pocket creation method of endoscopic submucosal dissection (PCM-ESD) and conventional ESD (CM-ESD). Methods: A comprehensive literature search was carried out in PubMed, China National Knowledge Infrastructure, and the Cochrane Library from their inception to July 2024 using medical subject headings and free-text terms, which were “pocket-creation method”, “gastric cancer”, “gastric neoplasms”, and “endoscopic submucosal dissection” or “ESD”. Two independent reviewers carried out the search, screened studies, and extracted data. Results: A total of 578 cases were included in our study, which sourced from …

Clinical Studies On Anti-Obesity Medications In Arab Countries, Haifa F. Alotaibi, Shadan Almuhaidib, Saud Alshagrawi, Abdulmalik Almufarrih, Ola Alalmai, Sahar Alnaserallah, Najla Alodah, Saleh A. Alqahtani, Waleed Alhazzani

Saudi Medical Journal

ABSTRACT Objectives: To identify and summarize studies carried out in Arab countries on anti-obesity medications (AOMs), with a focus on the types of medications investigated, study designs, and the efficacy/effectiveness and safety metrics reported. Methods: We carried out a comprehensive scoping review of primary studies examining the use of AOMs in adult Arab populations. Five databases (Medline, Embase, Cochrane Library, Index Medicus for the Eastern Mediterranean Region, and e-Marefa) were searched for English-language publications up to October 2024. Data extraction was carried out on study characteristics, participant demographics, interventions, and outcomes related to weight reduction, metabolic parameters, and side effects. …

The Risk Factors For Cardiovascular Disease And Chronic Kidney Disease In Patients With Nonalcoholic Fatty Liver Disease In Saudi Arabia, Walaa Mohammedsaeed, Abdullah Al Malki, Salma Alsayed

Saudi Medical Journal

ABSTRACT Objectives: To identify potential risk factors for chronic kidney disease (CKD) and cardiovascular disease (CVD) in Saudi Arabian patients with non-alcoholic fatty liver disease (NAFLD). Methods: A 6-year prospective cohort study was carried out from January 2018 to January 2023, enrolling 1,500 patients. Data were initially collected between January 2018-2019, and follow-up assessments were carried out annually from 2020-2023. Patients were evaluated using biomarker analyses, and medical records were reviewed to assess the incidence of CVD and CKD. Biomarker levels, including blood creatinine, urine albumin, glomerular filtration rate (GFR), atherogenic index of plasma (AIP), and other key parameters, were …

Longitudinal Analysis Of Foodborne Disease Outbreaks In Saudi Arabia: Trends And Demographic Patterns (2017-2023), Hissah A. Alzahrani

Saudi Medical Journal

ABSTRACT Objectives: To explore the long-term patterns of foodborne disease outbreaks (FBDOs) in Saudi Arabia between 2017-2023 using longitudinal data analysis models. Methods: A 7-year longitudinal study was carried out on FBDO data from all 13 regions of Saudi Arabia. This study examined 5 outcomes: the number of FBDOs, FBDO cases, and FBDO cases classified by gender, nationality, and age groups. The analysis used generalized estimating equations and generalized linear mixed models based on a negative binomial distribution. Results: The findings revealed a significant decrease in FBDO counts and cases from 2017-2020, followed by an increase until 2023. Public sources …

Psychological Stress And Its Association With Bronchial Asthma In Saudi Arabia: A Cross-Sectional Study, Alaa A. Bugis, Faisal A. Turkestani, Mohammed E. Ahmed, Mohammed M. Alqahtani, Abdullah K. Alnafisi, Bassam O. Alamri, Alhasan M. Algobayshi

Saudi Medical Journal

ABSTRACT Objectives: To investigate the psychological stress and its association with bronchial asthma in Saudi Arabia, focusing on the mechanisms by which stress affects asthma. Methods: This cross-sectional study included 733 adults with asthma aged ≥18 years and was carried out between October 2022 and May 2023 in Saudi Arabia. Data were obtained using an online questionnaire assessing asthma severity and stress levels. Results: Cronbach’s alpha indicated that the reliability of the stress scale was 0.728 and the reliability of the asthma control tool was 0.819. Of the participants, 52% were women and 48% were men, with 48.7% aged 18-26 …

Giving Voice To The Youngest Patients: Rethinking Pediatric Communication In Pharmacy Practice, Haifa F. Alotaibi

Saudi Medical Journal

No abstract provided.

Does Cancer Treatment Affect Connections In The Brain?

Saudi Medical Journal

No abstract provided.

Do Disasters Delay Early Cancer Diagnoses?

Saudi Medical Journal

No abstract provided.

Who Launches First-Ever Guidelines On Meningitis Diagnosis, Treatment And Care

Saudi Medical Journal

No abstract provided.