Digital Commons Network^™

Balancing Act: Retrofitting Office Design To Enrich Communities, Luke A. Griffith

Bachelor of Architecture Theses - 5th Year

The office workplace has shifted tremendously in the last decade. The world is adapting quickly to new technology and culture changes, but office buildings seem to be stuck in the past. COVID-19 has brought the world to a stand still and moved the way to do business to our homes. This shift has taught the workforce that most work can be done as efficiently at home than in the office. This leads to existing office buildings becoming rapidly vacant due to the lack of consistent occupancy throughout the work week. Where does that leave the future of the existing office …

Architecture Through Modularity, Jafet Estrada

Bachelor of Architecture Theses - 5th Year

Globally, an estimated 1.8 billion people lack access to adequate housing with an included 150 million people who live in permanent homelessness. Additionally, Housing costs have significantly outpaced income growth globally. Between 2014 and 2022, house price-to-income ratios have risen, with the global median ratio now at 6.1 (up from around 5 in 2014). Architecture through modularity could transform these lives with low-cost solutions. Modularity more broadly refers to a system’s ability to be broken down into smaller, self-contained, and interchangeable parts or modules. These modules function independently but are designed to work together as part of a cohesive whole. …

Big-Box Stores To Refuge: Transforming Commercial Spaces Into Modular Emergency Shelters, Garrett Byrne

Bachelor of Architecture Theses - 5th Year

As sea levels rise and climate disasters become more prevalent, this will displace residents. The importance of a scalable adaptable emergency shelter solution is vital. By proposing an renovation of existing big-box warehouses, such as Walmart, into refuge centers that can accommodate large number of displaced individuals. These refuge centers with their elevated platforms, strategic geographic distribution, and proximity to their flood zones, were well suited for elevated, climate resilient shelters. The design uses modular construction systems that uses kit-of-part beds that can be deployed for personal spaces and modules, enabling rapid assembly, flexible layouts, and efficient transportation. Elevated platforms …

Invisible Scholars, Emmaline Payne

Bachelor of Architecture Theses - 5th Year

In the United States, every year, there are approximately 1.3 million students who experience homelessness, an individual who lacks a fixed, regular, and adequate nighttime residence. Homelessness among students has a significant impact on their academic performance, mental health, and behavior. Factors like higher absenteeism, constant movement, and lack of support can all contribute to decreased academic achievement. Ultimately, this leads to students having to repeat grades or not graduating high school, compromising their abilities to succeed in the future. In addition to the decrease in academic achievement, behavioral and mental challenges exacerbated by the stress of housing instability also …

Aquatic Boundaries: Reimagining BeléN, A City Carried By Water And Resilience., Kassidy R. Mcclain

Bachelor of Architecture Theses - 5th Year

Rising water levels are not a distant threat. It is a reality that many cities already face. According to the Intergovernmental Panel on Climate Change, the global mean sea level has risen approximately 8–9 inches since 1880. The rising sea levels affect not only coastal cities but also cities along rivers and lakes attached to the sea by causing baseline water levels along rivers to increase. The rise in baseline water levels reduces the river's ability to drain effectively, thus causing riverside areas to become more susceptible to flooding. Traditional building methods meant to keep water out of buildings often …

Eos Wellness Center: Rethinking Inpatient Mental Health Facility Design, Emily Simms

Bachelor of Architecture Theses - 5th Year

The design of mental health facilities significantly impacts patient outcomes, especially for individuals with depression. Environmental factors such as lighting, thermal comfort, and access to nature influence mental health. This research explores how architectural design can reduce self-harm incidents and enhance recovery outcomes for patients with depression. The project hypothesizes that synchronizing light patterns and thermal comfort with patients’ circadian rhythms will reduce self-harm incidents and improve recovery. The problem established in the research is that disruptions to circadian rhythms increase the risk of depression, PTSD, and anxiety by 30% (Burns et al., 2022). Suicide is also the second leading …

Improving Therapeutic Communication Between Patients And Nurses Using The Commit To Sit Method In The Obgyn/Postpartum/Mother-Baby Unit, Simisola A. Shodunke

Doctor of Nursing Practice Final Project Abstract

Purpose

To improve patients’ perceptions of nurses by listening to their needs, helping nurses to engage with their patients therapeutically in the OBGYN/Postpartum/Mother-Baby unit. Aiming to increase patient satisfaction scores from 62.5% to 70% by December 2024 using the "Commit to Sit" method.

Background

The project was implemented in an OBGYN/Postpartum/Mother-Baby Unit, addressing the concerns of the patient’s perception of nurses not listening and addressing their needs which has contributed to a decline in patient satisfaction scores.

Methodology

The Plan-Do-Study-Act (PDSA) model was used. Nurses were trained to sit at eye level with patients for 3–5 minutes per shift. Data …

Noninvasive Assessment Of The Tumor Using Cfdna, Irfan Alahi

McKelvey School of Engineering Graduate Student Theses & Dissertations

Next-generation high-throughput sequencing, which is increasingly generating vast amounts of genomic data, offers opportunities for a deeper understanding of the multifaceted nature of cancer and, hence, better patient care. However, the inherently complex and heterogeneous nature of cancer and the significant challenges in the generated data demand advanced data-driven frameworks to decode the molecular underpinnings of cancer. Moreover, the undeniable need for non-invasive approaches presents additional technical challenges in this domain. This dissertation proposes novel frameworks addressing three key challenges in computational oncology. The first study of this dissertation develops a data-driven algorithm to identify stemness signatures in metastatic castration-resistant …

Cumulative Lifespan Stress And Inflammation Are Associated With Black-White Racial Disparities In Mortality Among Americans, Isaiah Spears

Arts & Sciences Graduate Student Theses and Dissertations

Black Americans disproportionately experience higher rates of health challenges and mortality compared to White Americans, yet the mechanisms underlying these disparities remain inadequately understood. Prominent theoretical models highlight stress and resulting allostatic load as putative mechanisms through which these Black-White racial disparities emerge; however, empirical data supporting such models with regard to mortality remains sparse. The current study examined the potential role of cumulative stress exposure across the life span and elevated levels of C-Reactive Protein, a biomarker of inflammation, in contributing to the longstanding increased mortality risk among Black relative to White Americans. Data were drawn from the Saint …

Mitochondrial Network Expansion And Loss During Oligodendrocyte Life And Death, Xhoela Bame

Dartmouth College Ph.D Dissertations

Oligodendrocytes are the myelinating cells of the central nervous system, known for modulating signal transmission, refining neural circuits, and providing metabolic support to axons. Oligodendrocytes are generated throughout life from oligodendrocyte precursor cells (OPCs) and are damaged or lost in demyelinating and neurodegenerative diseases and age-related pathologies. Thus, understanding the cellular checkpoints that occur during the generation and degeneration of oligodendrocytes is crucial for maintaining their population in health and recovering it in disease and aging.

Using high-resolution optical imaging, I have discovered a dynamic redistribution and subcellular partitioning of mitochondria during oligodendrogenesis. Mitochondria transiently expanded towards the differentiating OPC …

First-Principles Studies Of Electrical Polarization Effects In Ferroelectrics, Antiferroelectrics And Defects, Louis Alaerts

Dartmouth College Ph.D Dissertations

Over the last few decades, density functional theory (DFT) has emerged as a formidable tool in the field of computational material science. Not only has it become a complementary method approach to experiments by rationalizing the many complex properties of materials but its formidable predictive power can also be used to identify the most promising candidates for specific applications. Point defects in semiconductors have become an important platform for the development of quantum networks due to their ability to act as spin-photon interfaces. Spectral diffusion, the broadening of the optical emission line, can significantly impact the performance of these defect-based …

The Rising Returns To R&D: Ideas Are Not Getting Harder To Find, Yoshiki Ando, James Bessen, Xiupeng Wang

Faculty Scholarship

R&D investment has grown robustly, yet aggregate productivity growth has stagnated. Is this because “ideas are getting harder to find”? This paper uses micro-data from the US Census Bureau to explore the relationship between R&D and productivity in the manufacturing sector from 1976 to 2018. We find that both the elasticity of output (TFP) with respect to R&D and the marginal returns to R&D have risen sharply. Exploring factors affecting returns, we conclude that R&D obsolescence rates must have risen. Using a novel estimation approach, we find consistent evidence of sharply rising technological rivalry. These findings suggest that R&D has …

Examining Food Choice Determinants In Ncaa Division Iii Athlete Participants Representing Multiple Sports, Olivia Towne

Theses

Objective: To examine determinants of food choice among NCAA Division III athletes using the Athlete Food Choice Questionnaire (AFCQ), focusing on gender, sport type, and seasonal status. Participants: 72 NCAA Division III athletes from 13 sports at a private northeastern university participated in an online survey during Fall 2024. Methods: Participants completed the 32-item AFCQ assessing nine food choice factors. Independent t-tests and Pearson’s correlations were used to compare factor scores by gender, sport type, seasonal status, and team success. Results: Performance, Sensory Appeal, and Food Values and Beliefs emerged as the most influential factors in food choice, while Weight …

A Preliminary Study Of Hilbert–Kunz Functions: Coefficient Behavior In A Normal Affine Semigroup Ring, Jesus A. Mendiola Herrera

Theses and Dissertations

In 1890, David Hilbert published a set of notes on what now constitutes one of the bases of Commutative Algebra; his work would eventually influence the efforts of mathematicians like Ernst Kunz. In 1969, Ernst Kunz introduced a particular mapping regarding modules of regular local rings. His goal was to characterize Noetherian local rings of prime characteristic by computing the length of the composition series under Frobenius power transformations. In this thesis, the focus will be on stating the initial steps on finding the coefficients of the Hilbert-Kunz function of the normal affine semigroup ring of the form R = …

Genome Announcement Of Four Parechovirus A3 Isolates From The United States Of America., Debarpan Dhar, Terry Fei Fan Ng, Christopher J. Harrison, Eric Rhoden, Bernardo A Mainou, Anjana Sasidharan, Katelyn E. Vandonge, Varun Chandra Boinpelly, Rangaraj Selvarangan

Manuscripts, Articles, Book Chapters and Other Papers

We report the complete genome sequences of four parechovirus-A3 (PeV-A3) isolates from Children's Mercy Kansas City (CMKC), United States of America (USA): PeV-A3-MO-12-CMKC/CSF/MO/USA/2012 (isolated in 2012 from cerebrospinal fluid), PeV-A3-8C-CMKC/CSF/MO/USA/2022/ (isolated in 2022 from cerebrospinal fluid), PeV-A3-9C-CMKC/CSF/MO/USA/2022 (isolated in 2022 from cerebrospinal fluid), and PeV-A3-11B-CMKC/Blood/MO/USA/2022 (isolated in 2022 from blood). Sequence analysis revealed multiple mutations throughout the genome of the PeV-A3 isolates in comparison to the prototypic PeV-A3 A308/99 reference sequence (AB084913). Several unique amino acid changes were observed in the PeV-A3 isolates from 2022 that were absent in the PeV-A3 isolate from 2012. Phylogenetic analysis comparison determined that the …

How Much Should Consumers With Mild To Moderate Hearing Loss Spend On Hearing Devices?, Vinaya Manchaiah, Steve Taddei, Abram Bailey, De Wet Swanepoel, Hansapani Rodrigo, Andrew Sabin

School of Mathematical & Statistical Sciences Faculty Publications

Background: This study examined the relationship between hearing device price and sound quality. Method: A novel consumer-centric metric of sound quality (“SoundScore”) was used to assess hearing devices’ audio performance. Each hearing device is tested with two fittings. The “Initial Fit” is designed to approximate the most likely fitting for an individual with a mild-to-moderate sloping sensorineural hearing loss. The “Tuned Fit” includes adjusting parameters optimized to hit prescriptive fitting targets (NAL NL2) on an acoustic manikin. Each fitting is evaluated across five dimensions. Both fittings are combined using a weighted average to create a single number from 0 to …

Identifying Genetic Errors Of Immunity Due To Mosaicism, Elizabeth G Schmitz, Malachi Griffith, Obi L Griffith, Megan A Cooper

2020-Current year OA Pubs

Inborn errors of immunity are monogenic disorders of the immune system that lead to immune deficiency and/or dysregulation in patients. Identification of precise genetic causes of disease aids diagnosis and advances our understanding of the human immune system; however, a significant portion of patients lack a molecular diagnosis. Somatic mosaicism, genetic changes in a subset of cells, is emerging as an important mechanism of immune disease in both young and older patients. Here, we review the current landscape of somatic genetic errors of immunity and methods for the detection and validation of somatic variants.

Speech Stigma: Exploring Predictors Of Attitudes Toward Nonspeaking Autistic Individuals, Kate Herrmann

Honors College Theses

Roughly 30% of autistic individuals are nonspeaking, meaning they do not (or very minimally) communicate with speech. Many nonspeaking individuals have the ability to communicate with others by using augmentative and alternative communication, such as speech-generating devices or communication boards. The purpose of this study was to examine the attitudes of speaking individuals toward nonspeaking autistic people through a survey measuring attitudes and stigma toward nonspeaking people, autistic people, and disabled people, respectively. Predictors of attitudes, such as contact, knowledge, gender, and psychological inflexibility were examined. It was hypothesized that participants who have more contact with and knowledge of nonspeaking, …

Successful Strategies Utilized By Business Leaders To Balance Tax Planning With Profitability, Quarnelia Patterson

Walden Dissertations and Doctoral Studies

The absence of business tax planning strategies can lead to a higher tax burden. Business owners are concerned because a higher tax burden may result in lower after-tax earnings and reduced cash flow. Grounded in the PESTLE analysis framework, the purpose of this qualitative pragmatic inquiry study was to explore successful strategies that business leaders use to balance tax planning with profitability. The participants were eight small business owners located in the southwest United States who actively engaged in tax planning. Data were collected using semistructured interviews and a review of publicly available documents. Through thematic analysis, nine themes were …

Staff Education To Early Detection And Response To Patient Decline, Kein Gareth Rufino Pantaleon

Walden Dissertations and Doctoral Studies

This doctoral project implemented a staff education program to enhance early recognition and escalation of patient deterioration. Conducted at a 343-bed acute care hospital, the initiative addressed the ongoing problem of delayed detection and response to clinical decline, which often results in rapid response team activations and code blue events. Delays in intervention increase patient morbidity and mortality, despite many of these events being preventable through timely action. The project evaluated whether an interactive targeted education program could improve nursing staff’s knowledge, confidence, and willingness to activate escalation protocols, including Condition H and Code Help. Pre- and post-education surveys were …

Probation Officers Perceptions Of Probationers Economic Barriers To Successfully Complete Probation In Eastern North Carolina, Dwayne Ponton

Walden Dissertations and Doctoral Studies

This qualitative phenomenological study explored probation officers’ perceptions of the economic barriers that prevent probationers in Eastern North Carolina from successfully completing probation. Challenges such as unemployment, financial sanctions, housing instability, and debt were identified as key obstacles contributing to noncompliance and recidivism. Grounded in Merton’s Strain Theory, the study addressed a gap in research by focusing on the experiences of officers who directly supervise probationers facing economic hardship. Data was collected through semi-structured interviews with twelve officers and analyzed using thematic analysis. The study was guided by two research questions: (1) What economic barriers prevent probationers from successfully completing …

Developing An Effective Business Strategy For Microinsurance Demand In Nigeria, Adewale Ayokunle Adewusi

Walden Dissertations and Doctoral Studies

Nigerian insurance leaders face significant challenges in developing a sustainable microinsurance sector. Despite subsidies from governments and donors aimed at increasing demand, microinsurance operators struggle to expand and sustain their customer base, posing a critical challenge for industry leaders. Grounded in the cumulative prospect theory, the purpose of this qualitative multiple-case study was to explore strategies some insurance leaders in Nigeria use to grow and sustain business demand for microinsurance products. The participants were five insurance leaders in Nigeria who had employed successful strategies to develop and sustain business demand for microinsurance products. Data were collected using semistructured interviews and …

The Legacy Of Auguste Franchomme: Pedagogical Analysis And Performance Practice For The “Twelve Caprices Opus 7 For Cello Solo”, Zi-Yun Luo

LSU Doctoral Dissertations

This written document focuses on a personal pedagogical analysis of the Twelve Caprices composed by the French cellist and pedagogue, Auguste Franchomme. His works have served as significant cello studies for young cellists, comparable in importance to the Twelve Caprices by Carlo Alfredo Piatti and the High School of Cello Playing by David Popper. Each of these caprices is written in different key signatures, tempi, include a variety of bowing styles and techniques, express melodies over a wide range of the cello register, and present unique and ubiquitous issues that cellists may encounter in the canon of cello literature.

In …

Capstone Final Report: Coal To Nuclear – Nuclear Power Solutions, Owen Horiagon, James Russell, Thomas Scorpio, Nate Segar

Mechanical Engineering Capstone Design Projects

This project focuses on repurposing the retired Brayton Point coal plant into a next-generation clean energy facility by integrating a small modular reactor (SMR) to power a 250 MW AI data center. The purpose is to demonstrate a sustainable and technically sound solution that addresses both the rising demand for computational power and the need to decarbonize legacy infrastructure. Our objectives include designing and validating the NuScale SMR process, ensuring reliable integration with existing site assets, maintaining strict safety and licensing standards, and achieving zero net carbon emissions. The scope of work encompasses the complete system design, site retrofit planning, …

Mechanisms Of Protective Humoral Immunity And Pathogenesis In Alphavirus Infection, Natasha Monir Kafai

Arts & Sciences Graduate Student Theses and Dissertations

Alphaviruses are enveloped, mosquito-transmitted, positive-sense RNA viruses of the Togaviridae family classified into Old and New World groups based on endemic regions and human disease characteristics. Old World alphaviruses, including chikungunya virus preferentially cause arthritogenic disease, whereas New World viruses like Venezuelan equine encephalitis virus (VEEV), Eastern equine encephalitis virus (EEEV), and Western equine encephalitis virus (WEEV) can cause neurological disease. Since the 1920s, VEEV has been responsible for major periodic outbreaks affecting hundreds of thousands of humans and equines in South and Central America. Expansion of mosquito vectors raises concern for possible VEEV reemergence. In addition, VEEV is a …

Protocol For A Randomized Controlled Trial To Determine If Biomarkers Predict Response To A Pediatric Chronic Pain Symptom Management Program, Rona L Levy, Tasha B Murphy, Margaret M Heitkemper, Miranda A L Van Tilburg, Ann R Mcmeans, Jocelyn Chang, Cynthia Boutte, Katherine Lamparyk, Bruno P Chumpitazi, Robert J Shulman

Faculty, Staff and Students Publications

Background/Objectives: Disorders of gut-brain interaction (DGBI), characterized by chronic abdominal pain and significant disability, affect 15-20% of children and adults and continue into adulthood in ~60% of cases. Costs for adults reach USD 30 billion per year, yet effective management strategies are elusive. Studies support using cognitive behavioral therapy (CBT), but abdominal pain only improves in ~40% of patients. Dietary management (low FODMAP diet; LFD) has also shown promise but it is effective in only a similar percentage of patients. Studies suggest that biologic factors (biomarkers) contribute to CBT response. Similarly, gut microbiome composition appears to influence abdominal pain …

Antiamyloid Monoclonal Antibodies In Alzheimer’S Disease, Part 1: Patient Selection, James R. Bateman, Tara C. Carlisle, Yanghong Yang, Christian Lachner, Melissa D. Stockbridge, Laura A. Flashman, Zeina Chemali, Nasir Alzbeidi, Peter S. Pressman, Carlos J. Martinez-Menendez

School of Medicine Publications

The availability of monoclonal antibodies directed against amyloid beta, for use as disease-modifying therapies for Alzheimer’s disease (AD), represented a major shift in the field of AD research and treatment. U.S. Food and Drug Administration approvals for the monoclonal antibody–based medications lecanemab and, more recently, donanemab provide clinicians with two antiamyloid therapy (AAT) options for targeting early symptomatic AD. The emergence of AAT has made careful biomarker-informed diagnosis of AD paramount, which was once reserved for highly specialized centers and research settings. Patient selection is complex, and although appropriate-use recommendations have been published, clinicians caring for patients with AD across …

Catecholaminergic Polymorphic Ventricular Tachycardia-Linked Ryanodine Receptor Variants Exhibit Domain-Specific Calcium Leak And Calmodulin Affinity Properties, Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H T Wehrens, Takeshi Yamamoto, Razvan L Cornea, Robyn T Rebbeck, Masafumi Yano, Donald M Bers

Faculty, Staff and Students Publications

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited stress-induced arrhythmogenic disease often caused by point variants in the cardiac ryanodine receptor (RyR2) that enhance diastolic sarcoplasmic reticulum (SR) Ca2+ leak. These RyR2 variants cluster in three hot-spots (N-terminal, central and C-terminal domains). We previously demonstrated a pathologic diastolic RyR2 conformation in heart failure, oxidative stress and CaMKII phosphorylation exhibiting a trilogy of effects: (1) reduced calmodulin (CaM)-RyR2 affinity, (2) enhanced unzipping peptide (DPc10) binding and (3) elevated diastolic SR Ca2+ leak that are dantrolene-sensitive. Here we test whether this pathological trilogy occurs in CPVT knock-in (KI) mice bearing N-terminal (R176Q/+), …

Acquisition Algorithms For Protein Mass Spectrometry And Their Application To Clinical Proteomics, Nathan Wamsley

Arts & Sciences Graduate Student Theses and Dissertations

Bottom-up protein mass spectrometry aims for the identification and quantification of protein species by proxy of their proteolytic peptides. This dissertation presents methodological advances in three areas of protein mass spectrometry: acquisition methods, clinical appli- cations, and data analysis algorithms. The second chapter presents an optimized internal standard-triggered parallel reaction monitoring (OIS-PRM) method and demonstrates its application to study prognostic biomarkers in head and neck squamous cell carcinoma (HN- SCC). OIS-PRM uses intelligent scan scheduling and real-time monitoring of peptide elution profiles to reduce cycle-times and improve quantitative precision and accuracy. The assay measured NRF2 activation in both cell lines …

Proteogenomic Analysis To Inform Causal Gene Prioritization For Human Disease, Daniel Western

Arts & Sciences Graduate Student Theses and Dissertations

Genome-wide association studies (GWAS) have been key in expanding our understanding of the genetic contributions to common diseases. However, these genetic associations frequently fail to clarify causal disease mechanisms, as they often fall in non-coding regions and are difficult to interpret. One solution is to perform a GWAS for the levels of a cellular trait, known as quantitative trait locus (QTL) mapping. Through methods such as colocalization, Mendelian Randomization, and transcriptome/proteome-wide association studies, the QTL variants can be compared to disease GWAS, identifying shared variation between cellular and disease traits. We can then prioritize cellular traits as potential causative, targetable …