Digital Commons Network^™

Spatiotemporal Association Of Coronavirus Disease 2019 Cases And Deaths With Exposure To Wildfire Particulate Matter In 2020, Thomas C Mchale, David R Boulware, Kelly Searle, Leda Kobziar, Phinehas Lampman, Julio C Zuniga-Moya, Ben Papadopoulos, Andrej Spec, Naomi E Hauser, George R Thompson

2020-Current year OA Pubs

BACKGROUND: Climate change is anticipated to have profound effects on human health, including in infectious diseases. Wildfires have been increasing in frequency and intensity due to climate change and have been linked to worsening respiratory disease outcomes. We aimed to demonstrate whether there was an association between wildfire smoke and coronavirus disease 2019 (COVID-19) in California during 2020.

METHODS: We used an ecologic cohort study with a spatial autoregressive model to test for associations between wildfire smoke, measured as particulate matter < 2.5 µg/m

RESULTS: In an adjusted analysis, we found a 1-month lag increase of 203 COVID-19 cases per 10 000 persons …

Large-Scale Network Analysis Of The Cerebrospinal Fluid Proteome Identifies Molecular Signatures Of Frontotemporal Lobar Degeneration, Rowan Saloner, Nupur Ghoshal, Et Al.

2020-Current year OA Pubs

The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. Here we leveraged aptamer-based proteomics (>4,000 proteins) to identify dysregulated communities of co-expressed cerebrospinal fluid proteins in 116 adults carrying autosomal dominant FTLD mutations (C9orf72, GRN and MAPT) compared with 39 non-carrier controls. Network analysis identified 31 protein co-expression modules. Proteomic signatures of genetic FTLD clinical severity included increased abundance of RNA splicing (particularly in C9orf72 and GRN) and extracellular matrix (particularly in MAPT) modules, as well as decreased abundance of synaptic/neuronal and autophagy modules. The generalizability of genetic FTLD proteomic …

Screpertoire 2: Enhanced And Efficient Toolkit For Single-Cell Immune Profiling, Qile Yang, Ksenia R. Safina, Kieu Diem Quynh Nguyen, Zewen Kelvin Tuong, Nicholas Borcherding

2020-Current year OA Pubs

Single-cell adaptive immune receptor repertoire sequencing (scAIRR-seq) and single-cell RNA sequencing (scRNA-seq) provide a transformative approach to profiling immune responses at unprecedented resolution across diverse pathophysiologic contexts. This work presents scRepertoire 2, a substantial update to our R package for analyzing and visualizing single-cell immune receptor data. This new version introduces an array of features designed to enhance both the depth and breadth of immune receptor analysis, including improved workflows for clonotype tracking, repertoire diversity metrics, and novel visualization modules that facilitate longitudinal and comparative studies. Additionally, scRepertoire 2 offers seamless integration with contemporary single-cell analysis frameworks like Seurat and …

Cysteine Depletion Triggers Adipose Tissue Thermogenesis And Weight Loss, Aileen H Lee, Irina Shchukina, Prabhakar Sairam Andhey, Maxim N Artyomov, Et Al.

2020-Current year OA Pubs

Caloric restriction and methionine restriction-driven enhanced lifespan and healthspan induces 'browning' of white adipose tissue, a metabolic response that increases heat production to defend core body temperature. However, how specific dietary amino acids control adipose thermogenesis is unknown. Here, we identified that weight loss induced by caloric restriction in humans reduces thiol-containing sulfur amino acid cysteine in white adipose tissue. Systemic cysteine depletion in mice causes lethal weight loss with increased fat utilization and browning of adipocytes that is rescued upon restoration of cysteine in diet. Mechanistically, cysteine-restriction-induced adipose browning and weight loss requires sympathetic nervous system-derived noradrenaline signalling via …

Telemedicine In Nerve Surgery: An Effective Method To Determine Indications For Surgery, Noah S. Llaneras, Ruby L. Taylor, Jonah P. M. Orr, Rachel Alessio, Carolyn Carper, Brendan M. Patterson, Susan E. Mackinnon

2020-Current year OA Pubs

BACKGROUND: The COVID-19 pandemic accelerated the adoption of telemedicine for surgical consultations. Although patient satisfaction has been well documented, limited research exists regarding telemedicine's effectiveness in determining the ability to indicate for surgical care compared with in-office visits. We conducted a retrospective review comparing surgical decision-making via telemedicine versus in-person consultations, hypothesizing that in-office visits would be more effective in establishing a surgical plan than telemedicine.

METHODS: A retrospective review of the medical records of all new patients presenting to the senior author's nerve surgery clinic at a high-volume quaternary referral center between June 2020 and January 2023 was performed. …

Correlation Of Ultrasound And Electrodiagnostic Evaluation In Ballistic Peripheral Nerve Injuries, Mitchell S. Mologne, Zachary D. Randall, Nathan P. Olafsen, David M. Brogan, Christopher J. Dy

2020-Current year OA Pubs

BACKGROUND: Evaluation and management of ballistic peripheral nerve injuries remain controversial, and recent series have suggested higher rates of nerve discontinuity than previously appreciated. Ultrasound (US) may aid clinicians in the management of ballistic injuries. The goal of this study was to compare US findings to electrodiagnostic and intraoperative findings to assess its accuracy in ballistic injuries.

METHODS: We conducted a retrospective review of patients with the following criteria: (1) ballistic injury to the upper or lower extremity with suspected mixed or motor peripheral nerve injury; (2) underwent electrodiagnostic studies (EDX) and peripheral nerve ultrasound. US findings were categorized as …

Genetically Encoded Biosensors Of Metabolic Function For The Study Of Neurodegeneration, A Review And Perspective, Minglei Zhao, Saman Behboudi Tanourlouee, Sean Mccracken, Philip R Williams

2020-Current year OA Pubs

Nervous system tissue is the most metabolically active in the body and neurons are the primary consumers of oxygen and metabolites in nervous tissue. Many processes support neuronal metabolism, and dysregulation of these processes or intrinsic neuronal metabolism is often tied to neurodegenerative diseases. While many techniques are available to query metabolic function and disease (e.g. Seahorse XF, histology, immunostaining), almost all of these approaches are destructive and few offer cellular resolution. However, genetically encoded biosensors can optically measure metabolic features in any tissue with optical access. Biosensors represent an approach to non-destructively monitor metabolic components and regulatory signaling repeatedly …

A Systematic Review And Meta-Analysis Of Social Cognition Among People Living With Hiv: Implications For Non-Social Cognition And Social Everyday Functioning, David E Vance, Rebecca Billings, Crystal Chapman Lambert, Pariya L Fazeli, Burel R Goodin, Mirjam-Colette Kempf, Leah H Rubin, Bulent Turan, Jenni Wise, Gerhard Hellemann, Junghee Lee

2020-Current year OA Pubs

Social cognition-the complex mental ability to perceive social stimuli and negotiate the social environment-has emerged as an important cognitive ability needed for social functioning, everyday functioning, and quality of life. Deficits in social cognition have been well documented in those with severe mental illness including schizophrenia and depression, those along the autism spectrum, and those with other brain disorders where such deficits profoundly impact everyday life. Moreover, subtle deficits in social cognition have been observed in other clinical populations, especially those that may have compromised non-social cognition (i.e., fluid intelligence such as memory). Among people living with HIV (PLHIV), 44% …

Phase 2 Open-Label Study Of Sacituzumab Govitecan As Second-Line Therapy In Patients With Extensive-Stage Sclc: Results From Tropics-03, Afshin Dowlati, Anne C Chiang, Andrés Cervantes, Sunil Babu, Erika Hamilton, Shu Fen Wong, Andrea Tazbirkova, Ivana Gabriela Sullivan, Cédric Van Marcke, Antoine Italiano, Jilpa Patel, Sabeen Mekan, Tia Wu, Saiama N Waqar

2020-Current year OA Pubs

INTRODUCTION: The phase 2 TROPiCS-03 study evaluated the efficacy/safety of sacituzumab govitecan (SG) as second-line treatment in patients with previously treated extensive-stage SCLC (ES-SCLC).

METHODS: TROPiCS-03 (NCT03964727) is a multicohort, open-label, phase 2 basket study of solid tumors, including ES-SCLC. Adults with ES-SCLC that progressed after one previous line of platinum-based chemotherapy and anti-programmed death-(ligand) 1 (PD-[L]1) therapy received SG 10 mg/kg on days 1 and 8 of a 21-day cycle. The primary end point was the investigator-assessed objective response rate (ORR) according to Response Evaluation Criteria in Solid Tumors version 1.1. Key secondary end points included investigator-assessed duration of …

Plasma Mtbr-Tau243 Biomarker Identifies Tau Tangle Pathology In Alzheimer's Disease, Kanta Horie, Rama K Koppisetti, Nicolas R Barthélemy, Yingxin He, Chihiro Sato, Brian A Gordon, Hong Jiang, Tammie L S Benzinger, David M Holtzman, John C Morris, Suzanne E Schindler, Randall J Bateman, Et Al.

2020-Current year OA Pubs

Insoluble tau aggregates within neurofibrillary tangles are a defining neuropathological feature of Alzheimer's disease (AD) and closely correlate with clinical symptoms. Although tau pathology can be assessed using tau positron emission tomography, a more accessible biomarker is needed for diagnosis, prognosis and tracking treatment effects. Here we present a new plasma tau species, the endogenously cleaved, microtubule-binding region containing residue 243 (eMTBR-tau243), which specifically reflects tau tangle pathology. Across the AD spectrum in three different cohorts (n = 108, 55 and 739), plasma eMTBR-tau243 levels were significantly elevated at the mild cognitive impairment stage and increased further in dementia. Plasma …

Scoping Literature Review To Identify Candidate Domains For The Omeract Systemic Lupus Erythematosus Core Outcome Set, Wils Nielsen, Alfred Kim, Et Al.

2020-Current year OA Pubs

No abstract provided.

Perceptions Of Smoking Stigma Among African Americans: A Qualitative Study, Denine R. Crittendon, Alison C. Brecher, Samantha Okere, Richard Hass, Rosemary Frasso, Rickie Brawer, Mph, Phd, Charnita Zeigler-Johnson

College of Population Health Faculty Papers

INTRODUCTION: African Americans/Blacks (AAB) are at increased risk for morbidity and mortality from smoking-related diseases including lung cancer (LC). Smoking stigma is believed to be a primary barrier to health care-seeking for people who smoke. Previous studies illustrate that perceptions of smoking vary across populations. However, little is known about the prevalence of smoking stigmas among AAB. The purpose of this study was to increase understanding of the perception of cigarette smoking by AAB.

AIMS AND METHODS: We conducted free-listing interviews in which individuals listed all-thoughts and feelings regarding smoking and health-related questions with a convenience sample of eligible AAB …

Specialization Or Diversification? Creators’ Strategies On User-Generated Content Platforms, Ziwei Ye

Theses and Dissertations in Business Administration

Recent advancements in digital platforms have reshaped content creation and distribution. User-generated content (UGC), created and shared by internet users, is transforming entertainment, communication, and information sharing. The rise of UGC has fueled the growth of the "creator economy"—an ecosystem of creators, users, and advertisers facilitated by platforms such as YouTube and TikTok. While prior research has primarily explored how UGC platforms incentivize content quantity and quality, this study advances the literature by examining how creators' content strategies influence consumer attention and how platform mechanisms shape this relationship, offering new insights into the interplay between creator behavior and platform design. …

Property Testing Ai: An Efficient Frontier, Paul Sopher Lintilhac

Dartmouth College Ph.D Dissertations

In this dissertation, we take a step towards addressing the major problem of a lack of standardized and rigorous approaches to testing and evaluation of AI systems. Taking inspiration from both the fields of Property Testing and Property Based Testing (for programs), we develop a novel taxonomy of partially overlapping classes of properties of AI systems, including simple properties, compound properties, higher order properties, data relation properties, and architecture-utility properties. We argue that this taxonomy categorizes a diverse set of AI traits -- including accuracy, fairness, robustness, monotonicity, point-wise and global privacy properties, sensitivity, and more -- according to the …

Leadership Case Studies, Jayme Renfro, Anne Marie Gruber

Faculty Book Gallery

This volume is a collection of case studies by University of Northern Iowa's Master of Public Policy (MPP) graduate students, as well as undergraduate students studying leadership and management in public service. It is our hope that these case studies can be used as teaching and learning tools, as a deep-dive into leadership theory and practice.

Some details within the case studies, which are a combination of fiction and non-fiction, have been changed to protect privacy. Some student authors have chosen to remain anonymous or publish under a pseudonym.

Editor: Dr. Jayme Renfro, Associate Professor of Political Science, with support …

Media And Power, Bettina Fabos, Christopher R. Martin, Catherine H. Palczewski

Faculty Book Gallery

This handbook guides students through concepts, content, and exercises that help them develop media literacy by understanding media and power. The authors want students to not only gain the ability to critically analyze the languages and discourses – textual, visual, audio, and code – that people use to create and interpret media content, but also to understand the overarching context: media possess immense power in contemporary societies around the world.

Revised Draft Final Bpsou Unreclaimed Sites: Ur-05 Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Sails Symposium Launch On International Law Scholarship: What We Write, Where We Publish, And Why It Matters, Kathleen Claussen, Melissa J. Durkee, Rebecca Ingber, Steven Arrigg Koh

Faculty Scholarship

Despite the centrality of international law scholarship in international law, little work has been done to understand the contours and forces at work in what international law scholars write, where they publish that work, who reads international law scholarship, and scholarship's relationship to the policy world. For international lawyers, identifying answers to these questions and appreciating the impact of our collective work is essential, particularly at a moment of profound political struggle in communities around the world. We have remarkably few data as to what topics, methodologies, and perspectives of international law scholarship journals and publishers print, by whom, in …

Assessment Of Emergency Medicine Residents' Situational Awareness And Perception Of Patient Safety Culture In The Emergency Department, Adriana Olson, Nathan Olson, Nicholas Hartman, Casey Morrone, Morgan Battaglia, Kamna Balhara

Department of Emergency Medicine Faculty Papers

BACKGROUND: Situational awareness (SA) and positive safety climate are crucial to patient safety. Little is known about emergency medicine (EM) trainees' SA and perception of emergency department (ED) safety climate, and the interactions of those factors with safety-related behaviors.

OBJECTIVES: Our objective was to evaluate EM residents' perceptions of ED safety climate, self-reported SA, and comfort with identifying, rectifying, and reporting safety hazards.

METHODS: In this cross-sectional study at two EM residencies, residents completed the Situational Awareness Rating Technique (SART) after ED-based or simulated resuscitations as well as a survey regarding safety climate and comfort with identifying, rectifying, and reporting …

Understanding Disputes Over Digitalization: A Perspective Of Cross-Border Central Bank Digital Currencies, Heng Wang

Research Collection Yong Pung How School Of Law

In a rapidly digitalizing world, complex disputes would arise due to the technological, regulatory and other complexities. Public and private actors—including central banks, financial institutions, tech firms, and law firms—need to understand the complexity of these disputes before determining whether and how to engage with ongoing digitalization. Given the fundamental role of currency in the world economy, this article examines central bank digital currency (CBDC) as a pivotal case study. CBDCs, representing the digitalization of central bank money, are a novel digital form of national currency issued by central banks. Various central banks, including those of the Eurozone, Switzerland, the …

Synthesis Of Publications On The Anomalous June 2021 Heat Wave In The Pacific Northwest Of The United States And Canada, Erica Fleishman, David E. Rupp, Paul C. Loikith, Karin A. Bumbaco, Larry W. O'Neill

Geography Faculty Publications and Presentations

We synthesized more than 70 articles, most peer reviewed, that addressed the heat wave that occurred across the Pacific Northwest of the United States and Canada in late June 2021, breaking hundreds of daily and all-time daily maximum temperature records across the region. A persistent, extraordinarily strong ridge of high pressure was a primary driver of the heat wave. Contributing mechanisms were moisture originating in the tropical western Pacific Ocean, high solar radiation, low pressure offshore, large-scale subsidence over land, and unusually dry soils. Climate change contributed to the heat wave’s magnitude by increasing mean temperature, although it is unclear …

Lse-Net: Integrated Segmentation And Ensemble Deep Learning For Enhanced Lung Disease Classification, Bhavan Kumar Basavaraju, Mohammad Masum

Faculty Research, Scholarly, and Creative Activity

Accurate classification of lung diseases is vital for timely diagnosis and effective treatment of respiratory conditions such as COPD, pneumonia, asthma, and lung cancer. Traditional diagnostic approaches often suffer from limited consistency and elevated false-positive rates, highlighting the demand for more dependable automated systems. To address this challenge, we introduce LSE-Net, an end-to-end deep learning framework that combines precise lung segmentation using an optimized U-Net++ with robust classification powered by an ensemble of DenseNet121 and ResNet50. Leveraging structured hyperparameter tuning and patient-level evaluation, LSE-Net achieves 92.7% accuracy, 96.7% recall, and an F1-score of 94.0%, along with improved segmentation performance (DSC …

‘Making A Positive Environmental Impact’: Exploring The Role Of Volunteering At A Campus Community Garden, Dina Izenstark, Barbara Ann Boone

Faculty Research, Scholarly, and Creative Activity

Promoting sustainability in higher education is a social and environmental imperative. This paper explores how and why volunteering at a campus community garden (CCG) can serve as a unique context for promoting sustainability. Twenty-five undergraduate students between the ages of 18 and 27, who had volunteered at a campus garden, participated in individual semi-structured interviews. A majority of participants identified as female (80%) and Asian American (52%). Using reflexive thematic analysis, we first found students were motivated to volunteer for personal and academic reasons as well as to learn more about gardening. Childhood gardening experiences influenced participants’ re-engagement as adults. …

On The Application Of Long Short-Term Memory Neural Network For Daily Forecasting Of Pm2.5 In Dakar, Senegal (West Africa), Ahmed Gueye, Serigne Abdoul Aziz Niang, Ismaila Diallo, Mamadou Simina Dramé, Moussa Diallo, Ali Ahmat Younous

Faculty Research, Scholarly, and Creative Activity

This study aims to optimize daily forecasts of the PM2.5 concentrations in Dakar, Senegal using a long short-term memory (LSTM) neural network model. Particulate matter, aggravated by factors such as dust, traffic, and industrialization, poses a serious threat to public health, especially in developing countries. Existing models such as the Autoregressive integrated moving average (ARIMA) have limitations in capturing nonlinear relationships and complex dynamics in environmental data. Using four years of daily data collected at the Bel Air station, this study shows that the LSTM neural network model provides more accurate forecasts with a root mean square error (RMSE) of …

In Vitro Comparison Of Two Python-Based Programs For The Automated Analysis Of Tight-Junction Phenotype In Brain Endothelium During Bacterial Infection, Henry D. Mauser, Janessa Caroza, Shane Nicole Homez, Alyssa S. Arnett, William D. Cutts, Daryl W. Lam, Justin Thornton, Walter Adams, Brandon J. Kim

Faculty Research, Scholarly, and Creative Activity

Tight junction complexes are crucial features of brain endothelial cells, as they restrict the paracellular route across the blood–brain barrier. Tight junction disruption has been observed in conjunction with numerous diseases of the CNS. In such cases, the organization or integrity of cell–cell junctions may be analyzed with a variety of automated computer programs that quantitatively assess junction images. Here, we directly compare two previously developed python-based programs—JAnaP and IJOQ— for the semi- or fully automated analysis of tight junctions in human stem cell-derived brain-like endothelial cells. Cells were infected with S. pneumoniae and S. agalactiae to initiate junction disruption, …

The ‘Double-Exposure’ Of Riverine Communities In Northeast India To Dams And Climate Change, Costanza Rampini

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

Engineering Microphysiological Systems To Investigate Cellular Responses To Biophysical Cues In Human Tissue Microenvironments, Mehran Mansouri

Theses

Cells constantly sense and respond to biophysical cues in their microenvironment. Understanding how they interpret these mechanical signals is essential for advancing tissue modeling, studying disease mechanisms, and developing more predictive in vitro platforms. This dissertation presents a series of engineered microphysiological systems (MPS) designed to investigate how mechanical stimuli shape cellular behavior in distinct human tissue microenvironments. In Aim 1, I developed a reconfigurable microfluidic platform that mimics key features of human vascular barriers. This system supports the integration of porous membranes, 3D hydrogels, and flow channels, enabling precise control over both mechanical and biochemical cues. The modularity of …

Protocol For A Multisite, Parallel-Group, Randomized Clinical Trial Comparing A Brief Tele-Cognitive Behavioral Therapy Intervention (Bright) With Attention Control For The Reduction Of Body Image-Related Distress Among Head And Neck Cancer Survivors, Evan M Graboyes, Jessica R Vanderlan, Patrik Pipkorn, Sidharth V Puram

2020-Current year OA Pubs

One in four head and neck cancer (HNC) survivors experience clinically significant body image distress (BID), a devastating psychosocial morbidity that adversely affects quality of life. To date, effective interventions for these patients are lacking. BRIGHT (Building a Renewed ImaGe after Head and neck cancer Treatment), a brief cognitive behavioral treatment (CBT), has shown potential efficacy as a novel treatment paradigm for HNC survivors with BID. The primary objective of this randomized clinical trial (RCT) is to test the hypothesis that BRIGHT improves BID among HNC survivors relative to an Attention Control (AC) intervention. In this multisite RCT, N = …

White Matter Microstructure In School-Age Children With Down Syndrome, Dea Garic, Robert C Mckinstry, Natasha Marrus, Kelly N Botteron, Et Al.

2020-Current year OA Pubs

Down syndrome (DS) is the most common genetic cause of intellectual disability, but our understanding of white matter microstructure in children with DS remains limited. Previous studies have reported reductions in white matter integrity, but nearly all studies to date have been conducted in adults or relied solely on diffusion tensor imaging (DTI), which lacks the ability to disentangle underlying properties of white matter organization. This study examined white matter microstructural differences in 7- to 12-year-old children with DS (n = 23), autism (n = 27), and typical development (n = 50) using DTI as well as High Angular Resolution …

Developmental Lead Exposure And Aggression In Male Rats: Influences Of Maternal Care And Environmental Enrichment, Shamaila Zafar, Courtney K. Williams, Jaehyun Joo, Blanca E. Himes, Jay S. Schneider

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Developmental lead (Pb) exposure results in a variety of cognitive deficits and behavioral issues including increased antisocial behavior and aggression. This study investigated the effect of developmental Pb exposure on aggression and violent behavior in male rats and the potential modulatory influences of quality of maternal care and enriched/non-enriched housing conditions. Long-Evans male rats with or without Pb exposure (perinatal or early postnatal) from low or high maternal care mothers (based on amounts of licking/grooming and arched- back nursing) were randomly assigned to live in enriched or non-enriched environments at weaning. At post- natal day 120–190, offensive aggression was assessed …