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Articles 9421 - 9450 of 791945
Full-Text Articles in Entire DC Network
A New Electroencephalography Electrode Design For Curly And Kinky Hair Types, Elena Butler
A New Electroencephalography Electrode Design For Curly And Kinky Hair Types, Elena Butler
Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research
Medical discrimination and implicit bias are present in both societal systems and into the design and validation of medical devices. Traditional electroencephalography (EEG) systems often fail to provide reliable physiological recordings on curly and kinky hair types (3B–4C), associated typically with Black American and others of African descent. EEG on these hair types often results in high electrode-scalp impedance, poor signal quality, and participant discomfort. Consequently, such technical biases contribute to the underrepresentation of these populations in neuroscience research and clinical diagnostics, while simultaneously limiting equitable access to EEG-based medical care.
To address this gap, a novel conductive electrode attachment …
Beyond Local Pathology: Exploring The Role Of Gut Microbiota In Chronic Low Back Pain Using An Integrated Behavioral And Microbiological Approach, Adan L. Redwine
Beyond Local Pathology: Exploring The Role Of Gut Microbiota In Chronic Low Back Pain Using An Integrated Behavioral And Microbiological Approach, Adan L. Redwine
Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research
Chronic low back pain (LBP) affects millions worldwide, often originating from intervertebral disc (IVD) degeneration. While the gut microbiome modulates musculoskeletal pain, prior studies of the gut-disc axis have focused entirely on structural changes. This leaves a critical gap: does the microbiome influence the experience of discogenic pain? To answer this, an integrated approach using longitudinal gut microbiome profiling, machine learning-based behavioral phenotyping, and structural disc assessments in a rat model of discogenic LBP was utilized.
Female Sprague Dawley rats underwent one of four conditions: sham surgery, IVD injury, antibiotic-mediated microbiome depletion + IVD injury, or IVD injury + treatment …
Same-Sex Marriage In Taiwan: Soft Sovereignty, Threat Management, And The Politics Of Recognition In Asia, Olga Shalaeva
Same-Sex Marriage In Taiwan: Soft Sovereignty, Threat Management, And The Politics Of Recognition In Asia, Olga Shalaeva
University Honors Program Senior Projects
Why did Taiwan as a contested state with no seat in the United Nations (UN), shaped by Confucian conservatism and the world’s longest period of martial law become the first country in Asia to legalize same-sex marriage, while other Asian democracies with stronger institutional track records have not? This paper argues that democratic maturity alone cannot answer this question. What explains Taiwan’s 2019 marriage equality achievement is the strategic management of threat, operating simultaneously at the geopolitical and psychological levels, and the utilization of “soft sovereignty” as the “weapon of the weak.”
The paper introduces “soft sovereignty” as an in-progress …
The Muse Of Modern Day Celebrity Endorsements, Cassaundra Garcia
The Muse Of Modern Day Celebrity Endorsements, Cassaundra Garcia
University Honors Program Senior Projects
Kim Kardashian has redefined what it means to be a celebrity endorser in the modern age. It is not just about putting a celebrity face to a product, or in this case a Luxury Fashion Brand, but instead about embodying the brand itself. Kim Kardashian has served as the epitome of a ‘Modern Muse’, one who shapes and inspires brands. This thesis proposal takes an exploratory case study approach to Kardashian’s partnerships with Luxury Fashion Brands. It focuses on her Instagram social media presence and how it transforms traditional endorsement strategies into brand collaborations. By analyzing her posts, engagement, and …
Measuring School Anxiety In Pediatric Chronic Pain: Initial Investigation Of The Psychometric Properties Of The School Anxiety Inventory For Chronic Pain (Sai-Cp), Caitlyn Maye, Robert C. Gibler, Kristen E. Jastrowski, Dustin Wallace Phd, Cara M. Hoffart, Jenny Scheurich Phd
Measuring School Anxiety In Pediatric Chronic Pain: Initial Investigation Of The Psychometric Properties Of The School Anxiety Inventory For Chronic Pain (Sai-Cp), Caitlyn Maye, Robert C. Gibler, Kristen E. Jastrowski, Dustin Wallace Phd, Cara M. Hoffart, Jenny Scheurich Phd
Posters
Introduction: School anxiety is common among adolescents with chronic pain and often impacts academic and social functioning. Existing anxiety measures lack specificity for capturing the unique sources and symptoms of school-related anxiety in this population. To address this gap, a bank of new potential measure items (the School Anxiety Inventory for Chronic Pain [SAI-CP]), was developed based on the original School Anxiety Inventory (SAI), qualitative interviews with adolescents with chronic pain, and expert clinician input. The objective of this study was to evaluate the construct validity and internal consistency of the SAI-CP and identify avenues for future measure refinement. Method: …
Newly Registered Nurses With Neurodiversities: A Qualitative Study Of Their Experiences During Transition To Professional Practice, Heather Wallace
Newly Registered Nurses With Neurodiversities: A Qualitative Study Of Their Experiences During Transition To Professional Practice, Heather Wallace
Dissertations and Theses (Open Access)
Abstract Introduction: Transition-to-practice (TTP) programs play a crucial role in bridging the academic-to-practice gap for newly licensed Registered Nurses (NLRNs) and improving first-year retention rates. However, these programs may fall short in addressing the specific needs of NLRNs with neurodiversities (NLRN-ND). Neurodiversity (ND) encompasses Autistic Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), Tourette Syndrome, and the 3 Ds – Dyslexia, Dyscalculia, and Dysgraphia. Unsupportive environments for disclosing neurodiversity and requesting accommodations may contribute to the 10-25% NLRNs leaving their jobs within the first year, with 1-3% exiting the nursing profession altogether. Objectives: This study aimed to (1) explore NLRN-ND …
Exploring Teamwork Between Virtual And Bedside Nurses, Caitlin Weinheimer
Exploring Teamwork Between Virtual And Bedside Nurses, Caitlin Weinheimer
Dissertations and Theses (Open Access)
Background: Advancing technologies and the use of telehealth have expanded in hospitals to include telenursing. Telenursing introduces a unique dynamic where virtual and bedside nurses work together as a remote team to provide patient care. Published literature reports that teamwork among nurses and healthcare professionals impacts patient and workforce outcomes. However, there is a gap in exploring teamwork between virtual and bedside nurses. Addressing this knowledge gap is critical to ensure positive patient and nursing workforce outcomes in hospital-based telenursing settings.
Objective: To generate a grounded theory that explains teamwork between virtual and bedside nurses in the hospital setting. A …
Breastfeeding Education Preferences Of Pregnant People With Low Incomes, Megan Kindred
Breastfeeding Education Preferences Of Pregnant People With Low Incomes, Megan Kindred
Dissertations and Theses (Open Access)
Background: The proportion of infants breastfed at 1 year in the United States remains below the Healthy People 2030 goal. Longer breastfeeding durations are important due to dose-response benefits, but disparities are greater among those with low incomes. Prenatal breastfeeding education (PBE) interventions can increase breastfeeding duration. Additionally, incentivization and gamification can be used to increase use of educational technology but are underexplored in this domain. Prior studies examining PBE format preferences do not reflect currently available technology. PBE format preferences of childbearing people should be reexamined.
Purpose: This purpose of this study is to: (1) identify PBE format preference …
Faith Leaders’ Guide To Adolescent Protection, Population Council, Zambia Interfaith Networking Group (Zingo), Faith Mother Bodies
Faith Leaders’ Guide To Adolescent Protection, Population Council, Zambia Interfaith Networking Group (Zingo), Faith Mother Bodies
Adolescents and Young People
No abstract provided.
Election Fraud In The American Mind, Mitchell Brown, Spencer Goidel, Soren Jordan, Bridgett A. King, Isaac Westfall, Ryan Williamson
Election Fraud In The American Mind, Mitchell Brown, Spencer Goidel, Soren Jordan, Bridgett A. King, Isaac Westfall, Ryan Williamson
Political Science Faculty Publications
Objective: Disputes over election fraud have become a defining feature of contemporary American politics, yet it remains unclear whether partisans are disagreeing about the same underlying phenomenon. This article examines how Americans understand and interpret the phrase “election fraud” and whether partisan divisions reflect differences in concern about fraud or differences in what the term itself is taken to mean. Methods: We use novel survey questions included in our team's module of the 2024 Cooperative Election Study (N = 1000). An open-ended question captures respondents’ own top-of-mind associations with the phrase “election fraud,” while a closed-ended item asks respondents to …
Identifying Landscape And Behavioral Drivers Of Human-Black Bear Conflict In New Hampshire, Shea O'Connor
Identifying Landscape And Behavioral Drivers Of Human-Black Bear Conflict In New Hampshire, Shea O'Connor
Master's Theses and Capstones
Abundant American black bear (Ursus americanus) populations and increasing human development in New Hampshire have led to a prevalence of human-bear conflict across the state. This conflict negatively impacts humans, bears, and even the surrounding environment as safety is put at risk and environmental roles are disrupted. This thesis aimed to address both the ecological and human dimensions of human-bear conflict by combining a quantitative spatial analysis with a qualitative thematic analysis. Chapter One examined anthropogenic and landscape factors influencing human-black bear conflict levels across New Hampshire. I utilized ordinal logistic regression to analyze how various ecologically relevant predictor variables …
Learning From Practice: Autoethnographic Reflections & Practitioner Perspectives On Inclusive Engagement For Bipoc, Mml, And Special Education Students, Mikayla A. Aquino
Learning From Practice: Autoethnographic Reflections & Practitioner Perspectives On Inclusive Engagement For Bipoc, Mml, And Special Education Students, Mikayla A. Aquino
Program in Community Action (PICA)
This study examines how educators conceptualize, enact, and experience inclusive engagement for Black, Indigenous, and People of Color (BIPOC) students, multilingual learners (MLLs), and students with disabilities, and how structural conditions shape their capacity to implement equity-oriented practices. Drawing on semi-structured interviews with ten educators from Lakewood, Illinois, and Harborview, Connecticut, alongside autoethnographic reflection, this qualitative study centers practitioner voices to investigate the gap between educational policy and classroom practice. Grounded in Bettina Love's abolitionist teaching framework and Alison Kafer's political-relational model of disability, the analysis situates educator experiences within systems shaped by racism, linguistic hierarchy, and ableist normativity. Thematic …
The Baby And The Bathwater: Reproductive Abuse As Domestic Violence And Empowering Bodily Autonomy Through The Law, Kadhapriya Lindo
The Baby And The Bathwater: Reproductive Abuse As Domestic Violence And Empowering Bodily Autonomy Through The Law, Kadhapriya Lindo
University of Florida Journal of Law & Public Policy
Reproductive abuse—ranging from contraceptive sabotage and coerced pregnancy to coerced abortion and sexual violations such as stealthing—operates as a distinct and under-recognized form of domestic violence. By assessing medical, sociological, and legal research, it is clear how reproductive abuse holds a victim’s body and reproductive ability hostage, producing long-term physical, psychological, and familial harms. Existing criminal statutes, which focus on force-based sexual offenses, do not capture non-physical reproductive violations such as medication tampering or nonconsensual condom removal. Further, civil remedies, including tort claims and custody determinations, inadequately account for the harms of coerced conception and the long-term legal ties it …
Undue Hardship In Student Loan Bankruptcy: A Circuit-By-Circuit Analysis Of Brunner, Rahaf Alrehaili
Undue Hardship In Student Loan Bankruptcy: A Circuit-By-Circuit Analysis Of Brunner, Rahaf Alrehaili
University of Florida Journal of Law & Public Policy
The judicial landscape of student loan discharge under the Brunner test reflects both commonalities and significant divergences across circuits. While courts generally adhere to a shared framework for assessing undue hardship, they remain divided on key issues, including whether retirement savings qualify as necessary expenses, the extent to which religious tithing is protected under the Religious Liberty and Charitable Donation Protection Act (RLCDPA), and whether a debtor’s refusal to enroll in an income-driven repayment (IDR) plan constitutes bad faith under Brunner’s third prong. Courts also disagree on whether IDR eligibility should be considered under the first or second prong …
Florence Normal College Quarterly, Faculty Of Florence Normal College
Florence Normal College Quarterly, Faculty Of Florence Normal College
Documents
The first edition of the Florence Normal College Quarterly
A Case With Bite: Royal Canin U.S.A., Inc. V. Wullschleger And The Updated Removal Jurisdiction Landscape, Nicholas G. Glover
A Case With Bite: Royal Canin U.S.A., Inc. V. Wullschleger And The Updated Removal Jurisdiction Landscape, Nicholas G. Glover
The University of New Hampshire Law Review
Subject-matter jurisdiction is critical to every case, small or large. Establishing the court’s authority to adjudicate a present matter is tantamount to every case and for every judge. Despite the importance of properly entering and remaining in federal courts, civil procedure cases often receive far less fanfare than most others before the Supreme Court. Such was the case last term in Royal Canin U.S.A., Inc. v. Wullschleger, an overlooked case which silently reshaped removal jurisdiction jurisprudence. This Article details the importance of this quiet case. Through outlining entry into federal courts, introducing and reviewing the Eighth Circuit’s outlier—but correct—opinion …
Exploring The Lived Experiences Of Second-Career Educators, Kyle Avink
Exploring The Lived Experiences Of Second-Career Educators, Kyle Avink
Dissertations
School districts across the United States face a persistent teacher shortage driven by high attrition rates, declining enrollment in teacher preparation programs, and increasing demands on educators (Carver-Thomas & Darling-Hammond, 2017). Teacher attrition is especially high within the first three to five years, with nearly 40-50% of new teachers exiting within their first five years (Carver-Thomas & Darling-Hammond, 2017; Cells et al., 2023; Gray et al., 2015; Ingersoll et al., 2025). In response, many states have expanded alternative certification pathways that allow professionals from other fields to enter teaching, making second-career educators a potential solution to workforce challenges (Afacan, 2022; …
Exploration Of Expressive Prosody During Dyadic Conversation In Adults With Dementia, Kara Marie Sabanski
Exploration Of Expressive Prosody During Dyadic Conversation In Adults With Dementia, Kara Marie Sabanski
Undergraduate Honors Thesis Collection
Dementia is associated with progressive cognitive and communicative impairments that can contribute to social withdrawal and reduced quality of life. Although prior research has explored musical interventions and the use of prosodic features for early diagnosis, little is known about how expressive prosody is linked to engagement and communicative state during dyadic conversation in individuals with dementia. The present study examines different speech characteristics present in expressive prosody during conversation and explores whether these characteristics are associated with differences in conversational and behavioral engagement. Acoustic measures of pitch and speaking rate were analyzed during conversational interactions. Results indicated that prosodic …
Affective Perception Of Color In Classroom Design, Emmalyn Burns
Affective Perception Of Color In Classroom Design, Emmalyn Burns
Interior Design Undergraduate Honors Theses
The physical environment of a classroom plays a crucial role in shaping how students learn, engage, and interact with their education. This study focuses on color’s influence on well-being, focus, and overall academic experience. Many higher education classrooms still rely on a standard that implements neutral colors, which does not always align with student preferences. While prior research has shown that color can have measurable cognitive and emotional effects, its thoughtful application in university settings remains limited. Current architectural design processes often overlook ongoing user-based feedback past the pre-design phase, leaving students without input on the decisions for their learning …
Organizational Theory And Nurse Burnout: A Secondary Data Analysis Before And After Covid-19, Bridget Webb, Jennifer Mallow, Suzy Mascaro Walter, Kesheng Wang, Tina Antill Keener, Tim Cunningham
Organizational Theory And Nurse Burnout: A Secondary Data Analysis Before And After Covid-19, Bridget Webb, Jennifer Mallow, Suzy Mascaro Walter, Kesheng Wang, Tina Antill Keener, Tim Cunningham
Creating Healthy Work Environments (CHWE)
Background: Nurse burnout is a global health priority that has been compounded by Coronavirus 2019 (COVID-19). Organizational theory states that nurse burnout is directly impacted by operant mechanisms (nurse characteristics, nurse specialization) and hospital-wide models. The purpose of this study is to determine the relationship between hospital wide models (evidence-based care, team-based care, discharge planning, care coordination), operant mechanisms (nurse characteristics and specialization), and outcomes (nurse burnout) before and after COVID-19.
Design: A cross-sectional design was applied, using secondary data analysis.
Methods: A secondary data analysis using the 2018 and 2022 NSSRN data set was used to …
Exploring Online Social Capital Through The Lived-Experiences Of Students At A Southern Hispanic Institution: A Transactional Distance Approach, Marc Anthony Zamorano
Exploring Online Social Capital Through The Lived-Experiences Of Students At A Southern Hispanic Institution: A Transactional Distance Approach, Marc Anthony Zamorano
Theses and Dissertations
This qualitative transcendental phenomenological study examines how first generation Hispanic doctoral students at a southern Hispanic Serving Institution experience online engagement as a context for generating bonding, bridging, and linking social capital. Semi structured-in-depth interviews with 17 participants explored interactions with instructors, peers, course content, and technology. Analysis followed phenomenological reduction procedures to identify the essence of participants lived experiences. Key findings revealed that instructor presence and responsiveness strengthened bonding and linking capital; peer collaboration fostered belonging and bridging capital; and technology mediated tools reduced transactional distance when paired with clear course design and timely feedback. These relational and technological …
Empowering Latinas In Computer Science: Success Stories And Challenges, Martin Jalomo
Empowering Latinas In Computer Science: Success Stories And Challenges, Martin Jalomo
Theses and Dissertations
Latina women remain significantly underrepresented in computer science, and limited research centers their lived experiences within the field. This qualitative narrative inquiry examined how Latina women who completed computer science degrees and secured employment persisted in predominantly male and non-Latina environments. Guided by Yosso’s (2005) Community Cultural Wealth framework, the study explored how participants leveraged forms of capital to navigate structural, relational, and psychological barriers. Data were collected through narrative interviews with five Latina graduates and analyzed using thematic and cross-case analysis. Findings indicate that underrepresentation shaped participants’ sense of belonging while persistence was supported through aspirational, familial, social, navigational, …
“Sometimes I Feel That Going To College Was A Waste Of Time”: Latinas’ Lived Experiences Navigating Culture, Gender, And Marriage Post-College Degree, Nancy Peña
Theses and Dissertations
This qualitative critical narrative study explores how Latinas navigate and make meaning of gender roles within their heterosexual marriages post-college graduation. Data are collected via semi-structured interviews with 10 Latina participants: an initial plática focus group, followed by individual interviews, and a final plática focus group for member checking. Key findings reveal that despite Latinas acquiring autonomy, stability, negotiated power, personal growth, and social development as a result of attaining a degree in higher education, overall development is limited due to heightened responsibilities, persistent gender hierarchies, continuous religious norms, and constant gender role guilt. The evidence suggests that although attaining …
Skills, Challenges, And Career Outcomes: A Quantitative Study Of Early-Career Experiences In Research Administration, Jennifer Juliet Martinez
Skills, Challenges, And Career Outcomes: A Quantitative Study Of Early-Career Experiences In Research Administration, Jennifer Juliet Martinez
Theses and Dissertations
Research administration as a field lacks clearly defined entry pathways, with many professionals entering through indirect routes. These conditions contribute to variation in early-career experiences and may influence long-term outcomes. The purpose of this study was to examine how entry pathways and skills at entry relate to early-career challenges in research administration, and how those challenges are associated with career dissatisfaction.
This study used a quantitative, cross-sectional design. Data were drawn from the U.S. subset of the Research Administration as a Profession (RAAAP-3) survey. Key variables included entry pathways, skills at entry, early-career challenges, and career dissatisfaction. Findings indicate that …
The Relationship Between Secondary School Principals’ Ethical Leadership Behaviors And School Climate, Ericka Julie Carranza
The Relationship Between Secondary School Principals’ Ethical Leadership Behaviors And School Climate, Ericka Julie Carranza
Theses and Dissertations
Limited research explains how teachers in culturally and socioeconomically diverse secondary school settings experience principals’ ethical leadership behaviors and how those behaviors are perceived as shaping school climate. This qualitative study examined teachers’ perceptions of secondary school principals’ ethical leadership behaviors and the ways in which those behaviors were experienced as influencing relational, emotional, and professional dimensions of school climate.
Grounded in Social Learning Theory, the study employed a qualitative research design using semi-structured interviews and focus groups with secondary school teachers from diverse educational contexts. Data were analyzed using thematic analysis to identify patterns related to ethical leadership behaviors, …
Effects Of Vitamin E Deficiency On Anxiety-Like Behavior In Zebrafish With Distinct Stress Coping Styles, Areem Zahid
Effects Of Vitamin E Deficiency On Anxiety-Like Behavior In Zebrafish With Distinct Stress Coping Styles, Areem Zahid
Theses/Capstones/Creative Projects
Stress and anxiety disorders affect millions worldwide and represent a significant public health burden. Individual differences in stress coping style and antioxidant regulation contribute to variability in stress responsiveness and anxiety-related behaviors. Oxidative imbalance has been implicated in the neurobiology of anxiety, but its interaction with inherent stress coping phenotypes remains unclear. This study examined whether long-term dietary vitamin E deficiency alters anxiety-like behaviors in zebrafish selectively bred for proactive and reactive stress coping styles. Adult zebrafish were maintained on either a vitamin E–sufficient or vitamin E–deficient diet for five months, followed by behavioral assessment using the novel tank diving …
Using Behavioral Monitoring To Assess Activity Patterns And Welfare Indicators In Captive Black Howler Monkeys (Alouatta Caraya), Ramiro Gomez Iii
Using Behavioral Monitoring To Assess Activity Patterns And Welfare Indicators In Captive Black Howler Monkeys (Alouatta Caraya), Ramiro Gomez Iii
Theses and Dissertations
This study examined activity patterns and potential welfare indicators in captive black howler monkeys (Alouatta caraya) using behavioral monitoring techniques. A monogamous pair housed indoors at Gladys Porter Zoo was observed using focal sampling methods, and a species specific ethogram was developed to systematically record behavior. A total of 1,750 minutes of data were collected over one year. Observed behaviors were categorized into five groups: affiliative, agonistic, stationary, locomotion, and stereotypic behaviors. Activity budgets were calculated to determine the proportion of time allocated to each behavioral category. Results indicated that affiliative behaviors, particularly physical contact, dominated the activity budget, while …
I Am Still Learning, Too!: Pre-Service Teachers' Experiences Of Mathematics Anxiety In An Inquiry-Based Mathematics Education Course At Utrgv, Jeremiah James Adriano Dela Rosa
I Am Still Learning, Too!: Pre-Service Teachers' Experiences Of Mathematics Anxiety In An Inquiry-Based Mathematics Education Course At Utrgv, Jeremiah James Adriano Dela Rosa
Theses and Dissertations
Mathematics anxiety is a prevalent issue in mathematics education that negatively impacts students’ learning, performance, and engagement in mathematics. Prior research suggests that mathematics anxiety is often shaped by students’ experiences and emotional responses within the classroom environment.
The purpose of this study is to explore how Pre-Service Teachers experience mathematics anxiety in an Inquiry-Based Mathematics Education (IBME) classroom. This study employed a qualitative research design supported by descriptive survey data collected through the Abbreviated Mathematics Anxiety Scale (AMAS), selected components of the Fennema-Sherman Mathematics Anxiety Scale (FSMAS), and semi-structured interviews. The survey instruments were used to provide descriptive background …
Behavioral Bottlenecks In Belizean Smallholder Farming: An Action Plan, Mckinley A. Almeida
Behavioral Bottlenecks In Belizean Smallholder Farming: An Action Plan, Mckinley A. Almeida
Economics Undergraduate Honors Theses
Behavioral Bottlenecks in Belizean Smallholder Farming: An Action Plan investigates why Belizean smallholders hesitate to adopt new practices informed by a two-month internship with the Ministry of Agriculture at the Stann Creek branch. During the internship, a seventeen-page bilingual farm plan outline integrating SMART goals, a standard business plan, and farming essentials relevant to the local culture and environment was designed and developed. The Farm Plan Outline is grounded in observations in goal-setting theory, risk aversion under price uncertainty, and knowledge gap literature (AKIS/AKAP) tailored by smallholder Belizean contexts. Farmers were assisted with the Sustainable & Inclusive Belize Program grant …
Eptinezumab In Treatment-Resistant Chronic Migraine: Four-Year Real-World Effectiveness And Treatment Persistence, Wan-Jen Hsieh, Kelly Nicol, Chai Ching Ng, Tsung-Wei Hou, Phillip Phan, Scott W. Keith, Brittany Heckel, Michael J. Marmura, Hsiangkuo Yuan
Eptinezumab In Treatment-Resistant Chronic Migraine: Four-Year Real-World Effectiveness And Treatment Persistence, Wan-Jen Hsieh, Kelly Nicol, Chai Ching Ng, Tsung-Wei Hou, Phillip Phan, Scott W. Keith, Brittany Heckel, Michael J. Marmura, Hsiangkuo Yuan
Department of Neurology Faculty Papers
AimTo evaluate 48-month real-world outcomes of eptinezumab users in chronic migraine (CM), including longitudinal effectiveness, treatment persistence, reasons for discontinuation, and post-discontinuation anti-calcitonin gene-related peptide (CGRP) treatment patterns.MethodsWe conducted a retrospective cohort study of 112 CM subjects initiating eptinezumab at a tertiary headache center between 2019 and 2021. Monthly headache days (MHD), migraine disability assessment (MIDAS), and average pain intensity (API) were extracted at baseline and every 6 months for up to 48 months using a predefined outcome form at each visit. Longitudinal changes were analyzed using generalized estimating equations (GEE) with an unstructured correlation matrix, adjusting for age, sex, …