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Articles 34171 - 34200 of 793088
Full-Text Articles in Entire DC Network
Crucial Components Of An English Literacy Curriculum For Moroccan Adults, Philip J. Byler Mr.
Crucial Components Of An English Literacy Curriculum For Moroccan Adults, Philip J. Byler Mr.
Capstone Collection
This research paper examines the lived experiences and expertise of Moroccan teachers of English in teaching English literacy to Moroccan adults. Current research indicates that approximately 33 percent of Moroccan adults are illiterate. While there is research highlighting the need for adult literacy and its benefits, there is a lack of studies on how to develop an effective English literacy curriculum for Moroccan adults. Additionally, existing research underscores the growing importance of English in Morocco and the increasing desire among Moroccans to learn English.
Using a qualitative approach, this study explores the crucial components of an English literacy curriculum based …
Seoul’S Soul: A Study Of Drag Culture’S Influence On Queer Young Adult’S Education In South Korea, Ian Sollender
Seoul’S Soul: A Study Of Drag Culture’S Influence On Queer Young Adult’S Education In South Korea, Ian Sollender
Capstone Collection
Drag performance has long been considered a site of artistic expression, political resistance, and community-building within LGBTQ+ spaces. This capstone research project explores the educational impact of drag culture in Seoul, South Korea, with a particular focus on how drag performances serve as a pedagogical and educational tool that challenges gender norms, fosters queer community, and provides a platform for political discourse. Through qualitative analysis of participant observation, bilingual Korean and English survey responses, and in-depth English interviews with drag performers, performance organizers, and audience members, this research highlights the ways in which drag can function as a site of …
Shining In Times Of Crisis: How Refugee Women Display Leadership And Transform Hardship, Laura Iorg
Shining In Times Of Crisis: How Refugee Women Display Leadership And Transform Hardship, Laura Iorg
Capstone Collection
Abstract
There are currently approximately 122.6 million people displaced globally (UNHCR, 2024). This figure includes 43.7 million refugees (UNHCR, 2024). Nearly half of them are women. This qualitative study examined the following questions: How do women manifest leadership and agency in refugee situations? Subquestion: How do women contribute to peace, transformation, and healing through that leadership and agency? Five different individuals who had worked with women refugees for at least two years were recruited for the study. Two data collection instruments were employed: a preliminary survey and a structured interview. The study focused on the lived experiences of refugee women …
Let Us Break Bread Together: A Historical Analysis Of African American Chefs’ Influence On American Gastronomy, Danielle S. King
Let Us Break Bread Together: A Historical Analysis Of African American Chefs’ Influence On American Gastronomy, Danielle S. King
Capstone Collection
This Capstone project examines the historical impact of African American chefs on American gastronomy, highlighting their substantial contributions to the nation's culinary heritage from 1619 to 2024. By employing Jessica B. Harris's book High on the Hog as a foundation, the research identifies a critical gap in existing study abroad programs: the Black diaspora within the United States. The proposed four-week educational program aims to immerse participants in African American culinary heritage across four culturally rich cities: Charleston, South Carolina; New Orleans, Louisiana; Chicago, Illinois, and Oakland, California. With a community cultural wealth framework, the program integrates historical research, hands-on …
Combat Motivation And Swift Trust In Canada’S Battle Of Hong Kong, 1941, Robert C. Engen, Maxwell Putnam
Combat Motivation And Swift Trust In Canada’S Battle Of Hong Kong, 1941, Robert C. Engen, Maxwell Putnam
Canadian Military History
Abstract: In December 1941, the British Crown Colony of Hong Kong was the site of a doomed last stand, when the Imperial Japanese Army assaulted the British enclave near-simultaneously with the strike on Pearl Harbor. Among Hong Kong’s multinational defenders were two battalions of Canadian infantry, designated “C Force.” They held out for a significant period and inflicted heavy casualties upon the Japanese, despite the fact that the Canadians were under-trained, under-equipped and fighting a battle that could not be won. This article is the first major study of combat motivation in the Battle of Hong Kong, taking the Canadian …
"That Movie Changed Me!" Effect Of Induced Mood On Story Interpretation, Rachel Deborah Thayer
"That Movie Changed Me!" Effect Of Induced Mood On Story Interpretation, Rachel Deborah Thayer
2025 Symposium
Studies have found that mood can affect a variety of aspects of cognition, such as memory, comprehension, and decision making. In one such study, participants identified with the character that reflected their hypnotically induced mood, and in another, story endings that were incongruent with the film clip-induced mood were more difficult to process. In the current study, film clips were used to induce moods, and participants were asked to write an ending to an ambiguous story. The prediction is that participants’ completions will reflect their induced mood. To date, 25 Eastern Washington University undergraduate students have been recruited and screened …
Assessing The Lgbtq+ Beliefs, Behaviors, And Competency Of Nutrition Professionals: A Mixed-Methods Study, Anthony Dissen, Christina Riccardo, Liam Oliver Lair
Assessing The Lgbtq+ Beliefs, Behaviors, And Competency Of Nutrition Professionals: A Mixed-Methods Study, Anthony Dissen, Christina Riccardo, Liam Oliver Lair
Journal of Dietetic Education
Lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ+) individuals often experience disproportionate levels of physical and mental health issues including nutrition-specific issues such as eating disorders, body dysmorphia, and food insecurity related to psychological distress from discrimination and stigmatization. This study sought to understand nutrition professionals’ LGBTQ+ competence, beliefs, and behaviors. Researchers distributed 2 data collection tools to registered dietitian nutritionists (RDNs): the Gay Affirmative Practice Scale (GAP-Scale) and the LGBT Competency Assessment Tool (LGBT-CAT). Data from the GAP-Scale were numerically scored using a 5-point Likert scale, and data from LGBT-CAT were scored on a scale of 0 to 3 points. …
Development Of Dietetics Students’ Skills And Self-Efficacy In The Nutrition Care Process, Kristen Heitman, Marcia Nahikian-Nelms, Holly Estes-Doetsch, Kristen M. Roberts, Jennifer A. Garner, Julie Kennel, Christopher A. Taylor
Development Of Dietetics Students’ Skills And Self-Efficacy In The Nutrition Care Process, Kristen Heitman, Marcia Nahikian-Nelms, Holly Estes-Doetsch, Kristen M. Roberts, Jennifer A. Garner, Julie Kennel, Christopher A. Taylor
Journal of Dietetic Education
The Nutrition Care Process (NCP) is a systematic framework for providing nutrition care and a cornerstone of dietetics practice. Dietetics education relies on development of skills to achieve competence and demonstrate readiness for practice. The relationship between development of fundamental skills and self-efficacy among dietetics students preparing for clinical practice remains unclear. The purpose of this study was to examine the development of dietetics students’ skills in NCP documentation and their self-efficacy in performing the skills over one academic year. Student nutrition notes (n = 120 notes, n = 30 students) from standardized patient encounters were evaluated for quality using …
Integrated Advanced Education Supports Future Registered Dietitian Nutritionists’ Breastfeeding Self-Efficacy In Practice, Crystal C. Douglas, Simone Camel
Integrated Advanced Education Supports Future Registered Dietitian Nutritionists’ Breastfeeding Self-Efficacy In Practice, Crystal C. Douglas, Simone Camel
Journal of Dietetic Education
Objective: Evaluate the effectiveness of graduate-level breastfeeding and lactation management education that includes didactive and active learning components on future RDNs’ knowledge, attitudes, and self-efficacy. Design: A pre-and post-test design, utilizing a 41-item pre-intervention survey, learning modules, and a 35-item post-intervention survey. Setting: Three U.S. public universities located in Texas, Louisiana, and Arkansas. Participants: Graduate-level dietetic internship students. Intervention: Four advanced education modules (2 didactive; 2 active learning) developed by Registered Dietitian Nutritionists. Main outcome measures: Gains in breastfeeding knowledge, attitudes, and self-efficacy to assist with breastfeeding education and problem-solving using validated and newly developed survey items. Analysis: Descriptive statistics, …
Comparison Of Offspring Growth Models In Atlantic Puffins Fratercula Arctica , Katja H. Kochvar, Raul Zabala Belenguer, Pierre-Paul Bitton
Comparison Of Offspring Growth Models In Atlantic Puffins Fratercula Arctica , Katja H. Kochvar, Raul Zabala Belenguer, Pierre-Paul Bitton
Marine Ornithology
Growth of morphological traits in the offspring of many seabirds, including Atlantic Puffins Fratercula arctica, has typically been characterized by linear models despite displaying nonlinear patterns. We assessed the fit of six typical avian growth models to measurements of puffling mass, wing length, and tenth primary length. Across all three biometrics, the first- and second-best performing models were nonlinear (i.e., quadratic, logistic, extreme value function); these models were then used to generate separate growth curves for individual pufflings and extract easily interpretable and comparable parameter estimates. We recommend the reported models in future studies incorporating metrics of puffling growth and …
Following Painting's Quiet Call To Adventure, Kelly Allen
Following Painting's Quiet Call To Adventure, Kelly Allen
The Open Journal of Occupational Therapy
Yael Goverover, OTR/L, Ph.D., professor and post-professional program director of occupational therapy at New York University at Steinhardt (NYU), provided the cover art for the summer issue of the Open Journal of Occupational Therapy. This oil painting on canvas, titled, Still Life, 2024, features an arrangement of everyday objects with vibrant tones of gold, yellow, orange, and green found in the vase, and a coffeepot, fruits, and botanicals set against a backdrop of scarlet and striped patterned fabrics. She created this piece while on sabbatical in Israel as she studied under the tutelage of a seasoned oil …
Environmental Advocacy As An Occupation: Perceived Self-Efficacy And Occupational Justice In Community Programming, Emma Sims, Laura H. Vanpuymbrouck
Environmental Advocacy As An Occupation: Perceived Self-Efficacy And Occupational Justice In Community Programming, Emma Sims, Laura H. Vanpuymbrouck
The Open Journal of Occupational Therapy
Background: Current occupational therapy literature demonstrates a gap in knowledge of environmental advocacy as an occupation, which directly impacts occupational justice in those experiencing environmental racism or discrimination. This study’s purpose was to provide foundational information on the importance of advocacy work in the sphere of environmental and occupational justice through the lived experiences of those directly involved in community environmental advocacy.
Method: Qualitative data was collected via three focus groups using semi-structured interviews focused on perceptions of participant experiences in environmental advocacy occupations. Thematic analysis was used to identify themes relating to research questions.
Results: When …
Benefits Of Strategic Memory Advanced Reasoning Training (Smart) In Occupational Therapy Graduate Students, Asha K. Vas, Lori G. Cook, Wanyi Wang, Alisha Schaefer
Benefits Of Strategic Memory Advanced Reasoning Training (Smart) In Occupational Therapy Graduate Students, Asha K. Vas, Lori G. Cook, Wanyi Wang, Alisha Schaefer
The Open Journal of Occupational Therapy
Occupational therapists engage in critical thinking to integrate knowledge into clinical application. Academic curricula offer critical thinking strategies to facilitate flexible thinking and innovation to optimize clinical outcomes. Prior research has demonstrated that a gist-based reasoning program called Strategic Memory Advanced Reasoning Training (SMART) is beneficial in improving critical thinking skills in both healthy and clinical populations. The current study examined the benefits of the SMART program in masters-level occupational therapy (OT) students. Fourteen students between the ages of 22 and 45 (M = 25.71, SD = 6.34) completed the research study. The SMART program teaches strategies of strategic attention, …
Prevalence Of Incivility And Bullying In Occupational Therapy Fieldwork, Edwin Myers, Kaitlyn Cremer
Prevalence Of Incivility And Bullying In Occupational Therapy Fieldwork, Edwin Myers, Kaitlyn Cremer
The Open Journal of Occupational Therapy
The prevalence of incivility and bullying in the domain of occupational therapy warrants attention. The long-term effects of incivility and bullying can be profound and multifaceted. These may include job dissatisfaction, depressive symptoms, heightened hostility, and an increased likelihood of malpractice. Despite the implications of such behavior, there remains a noticeable gap in existing literature. This study investigated the prevalence of incivility and bullying occurring during occupational therapy (OT) fieldwork. The Negative Acts Questionnaire-Revised (NAQ-R) was completed by 702 occupational therapists, occupational therapy assistants, and students regarding their fieldwork experiences. Over 80% of participants reported being exposed to bullying or …
Occupational Therapy Students’ Perceptions Of Using Chatgpt For An Academic Course Assignment, Diane Tom, Robyn Wu, Chi-Kwan Shea
Occupational Therapy Students’ Perceptions Of Using Chatgpt For An Academic Course Assignment, Diane Tom, Robyn Wu, Chi-Kwan Shea
The Open Journal of Occupational Therapy
Chat Generative Pre-Trained Transformer (ChatGPT), a natural language based artificial intelligence (AI), has been either welcomed or maligned by academia. This project aimed to: (a) provide a structured opportunity for students to use ChatGPT and critique its responses and (b) investigate student perceptions before and after using ChatGPT for a class assignment. Forty graduate occupational therapy students used ChatGPT to complete two written assignments. Pre- and post-ChatGPT assignment surveys completed by students were analyzed. After using ChatGPT to complete course assignments, students were significantly more likely to agree that: (a) ChatGPT is helpful for completing assignments, (b) ChatGPT provides accurate …
Becoming A Skater: A Mixed Methods Study Exploring Supports And Barriers To Participation In Adaptive Skateboarding, Megan Sandwith, Susan Macdermott, Amy Griswold
Becoming A Skater: A Mixed Methods Study Exploring Supports And Barriers To Participation In Adaptive Skateboarding, Megan Sandwith, Susan Macdermott, Amy Griswold
The Open Journal of Occupational Therapy
Background: The occupation of adaptive skateboarding expands concepts of skateboarding through modifications that support performance for individuals with disabilities. There is a gap in the literature representing the experience of individuals with disabilities who desire to participate in adaptive skateboarding. The intent of the research study was to provide a foundational understanding of the occupation of adaptive skateboarding by exploring the question: What are the supports and barriers to participation in adaptive skateboarding?
Methods:This mixed-methods study was comprised of a 14-question virtual survey, a semi-structured interview, and an optional video submission.
Results: A total of 41 participants participated …
Paving A Path From Occupational Therapy Clinician To Researcher: A Grounded Theory, Marissa J. Wuennemann, Barbara Nadeau
Paving A Path From Occupational Therapy Clinician To Researcher: A Grounded Theory, Marissa J. Wuennemann, Barbara Nadeau
The Open Journal of Occupational Therapy
Background: Research is vital for continued development and support of practice for occupational therapy, yet little is known about occupational therapists currently in research roles. Occupational therapists who primarily conduct research see themselves as a unique minority in the profession. This study aimed to understand the process of occupational therapists who shift their professional identity from being a clinician to a researcher.
Method: Purposive and snowballing sampling was used to recruit occupational therapy clinicians who transitioned into roles where they spend the majority of their time conducting research. Data was collected through individual, semi-structured interviews and analyzed following …
Enhancing Occupational Therapy Practice Through A Mentorship Program: A Qualitative Study, Natalie S. King, Bryan M. Gee, Sarah A. Schoen, Mim Ochsenbein
Enhancing Occupational Therapy Practice Through A Mentorship Program: A Qualitative Study, Natalie S. King, Bryan M. Gee, Sarah A. Schoen, Mim Ochsenbein
The Open Journal of Occupational Therapy
Background: Occupational therapy entry-level education is filled with opportunities for experiential learning. Post-professionally, few opportunities exist for participation in structured mentored experiences. Mentoring in health care professions is not new; it has resurged over the past 15 years, documenting the nature of mentorship for practicing clinicians, the design of programs to promote advancement, and the effectiveness of these programs. Level I Mentorship by the STAR Institute uses a small group format and entails a blend of live and online instruction, fostering discussion and reflection rooted in on-site learning experiences. This qualitative study aims to understand participants' perceptions of STAR …
Use Of Podcasts As Emerging Technology In Occupational Therapy Education, Abbigail Kubiak, Karen Jacobs, Varsha S. Kulkarni, Maruška Vizek
Use Of Podcasts As Emerging Technology In Occupational Therapy Education, Abbigail Kubiak, Karen Jacobs, Varsha S. Kulkarni, Maruška Vizek
The Open Journal of Occupational Therapy
Podcasts are an emerging modality with a developing evidence base to reinforce their use in educational settings; in particular, to support knowledge retention and introduce topics. This research demonstrates the potential of podcasting in an educational context. Podcasts were used to educate occupational therapy (OT) students about emerging and innovative OT career opportunities. A series of 13 standardized 20- to 30-min podcasts featuring occupational therapists in emerging and innovative practice areas (E/IPA) globally were developed. In each podcast, the occupational therapist described implicit and explicit aspects of their career experiences. The podcasts were piloted in an entry-level OT doctoral course …
A Qualitative Study Of Disabled Performance Art In Occupational Identity Formation And Empowerment, Lisa Mahaffey, Kristin Chrissos, Kate Wettergren
A Qualitative Study Of Disabled Performance Art In Occupational Identity Formation And Empowerment, Lisa Mahaffey, Kristin Chrissos, Kate Wettergren
The Open Journal of Occupational Therapy
Background: Disabled performance artists use their occupation of performance art to challenge the attitudes of their audience toward disability, leading to a greater sense of empowerment and a strong identity as disabled people.
Method: This project used a narrative approach to qualitative inquiry to explore how engagement in performance art influences occupational identity and empowers disabled artists. Personal connections and snowball sampling resulted in six self-identified disabled performance artists participating in 60- to 90-min interviews. A thematic analysis resulted in three overarching themes.
Results: (a) Belonging to a community of disability activists promotes feelings of empowerment for disabled performance …
Motivational Interviewing For Weight Loss: A Review Of Evidence-Based Outcomes In Overweight And Obese Adults, Marian Dover
Motivational Interviewing For Weight Loss: A Review Of Evidence-Based Outcomes In Overweight And Obese Adults, Marian Dover
Dissertations
Obesity is a significant clinical problem affecting 41.9% of adults in the United States, with profound implications for individual health and healthcare economics. Standard weight loss interventions, often limited to pharmacological treatments and dietary guidance, frequently fail to achieve sustained adherence and meaningful longterm outcomes. This quality improvement (QI) project evaluated the integration of motivational interviewing (MI), a patient-centered counseling strategy, into routine clinical practice at Innovafusion, a medically supervised weight loss clinic in Aubrey, Texas. The aim was to enhance adherence to lifestyle modifications, promote intrinsic motivation, and improve weight loss outcomes among adults aged 18–65. Using a retrospective …
Screening For Depression And Anxiety In Women With Polycystic Ovarian Syndrome, Nicole M. Bondurant
Screening For Depression And Anxiety In Women With Polycystic Ovarian Syndrome, Nicole M. Bondurant
Dissertations
Background: Polycystic Ovarian Syndrome (PCOS) is a multifaceted endocrine disorder that affects up to 20% of women of reproductive age and is associated with an increased prevalence of psychiatric conditions, particularly depression and anxiety. Despite international guidelines recommending routine screening for these mental health conditions in women with PCOS, consistent implementation in clinical practice remains limited.
Methods: This quality improvement (QI) pilot project aimed to address this gap by developing and implementing a standardized screening protocol for depression and anxiety within a suburban concierge OB-GYN clinic specializing in women’s reproductive and sexual health using validated tools—the Patient Health Questionnaire-8 (PHQ-8) …
Implementation Of Mindfulness-Based Interventions And Weekly Visits To Reduce Loneliness In Older Adults, Victoria E. Cobb
Implementation Of Mindfulness-Based Interventions And Weekly Visits To Reduce Loneliness In Older Adults, Victoria E. Cobb
Dissertations
Implementation of Mindfulness-Based Interventions and Weekly Visits to Reduce Loneliness in Older Adults
Abstract:
Problem: Social isolation and loneliness have emerged as a significant public health issue for the older adult population. Loneliness has been linked to both physical and mental health effects. According to current literature, there is no standard intervention to treat loneliness in the older adult population.
Methods: This quality improvement (QI) project utilized a descriptive cohort design and the Visit-A-Bit screening assessment instrument. Undergraduate nursing students implemented mindfulness interventions during weekly visits over an eight-week period at an independent living facility located in the Midwest. Descriptive …
Implementing Behavioral Management And Social Skills Training For Pediatric Patients With Adhd And Their Caregivers, Meagan A. Conwell
Implementing Behavioral Management And Social Skills Training For Pediatric Patients With Adhd And Their Caregivers, Meagan A. Conwell
Dissertations
Problem: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects 11.4% of children in the United States. Patients diagnosed with ADHD struggle with focus, hyperactivity, and impulsivity, resulting in executive and emotional dysfunction, poor social skills and quality of relationships, and poor school performance.
The American Academy of Pediatrics guidelines recommend that school-age children diagnosed with ADHD should receive both medication management and behavioral management training (BMT) for the best treatment outcomes. Research over the last decade has found that combining social skills training (SST) with BMT results in even better outcomes for these patients. Less than half of pediatric …
Race-Neutral Pft: Implementing Patient Activation Measure Following Race- Neutral Pulmonary Function Testing, Ann M. Way
Race-Neutral Pft: Implementing Patient Activation Measure Following Race- Neutral Pulmonary Function Testing, Ann M. Way
Dissertations
Abstract
Background
The introduction of a race-neutral equation to predict normal values on pulmonary function testing (PFT) has led to changes in the diagnosis of pulmonary diseases previously diagnosed using a race specific equation. Minority patients appear to be most likely impacted by this change, potentially impacting how they self-manage their pulmonary health. Patient self-management can be measured and assessed by using the Patient Activation Measure (PAM) tool.
Purpose
The purpose of this project is to assess patient activation levels amongst minority patients with a new or changed pulmonary diagnosis to identify a possible need for interventions to improve patient …
Improving Hpv Vaccination Decision-Making For Adolescents And Their Caregiver, Mary E. Hohman
Improving Hpv Vaccination Decision-Making For Adolescents And Their Caregiver, Mary E. Hohman
Dissertations
Abstract
Problem: Human papillomavirus (HPV) is a viral infection associated with the development of certain cancers and is the most common sexually transmitted infection in the United States (U.S.) (Centers for Disease Control and Prevention [CDC], 2023). The CDC (2021) asserts that more than 90% of cancers caused by HPV infections could be prevented through the HPV vaccination. The CDC recommends the HPV vaccine series for children ages 11 or 12 years; however, this organization further submits that the HPV series could be initiated as early as 9 years of age through 26 years of age (CDC, 2024). Despite CDC …
The Psychological Impact Of Parenting Child Victims Of Trauma, Stephanie Faulkingham
The Psychological Impact Of Parenting Child Victims Of Trauma, Stephanie Faulkingham
Dissertations
Abstract
Research indicates that non-offending caregivers of traumatized children (NOC) is a population with an elevated risk for increased levels of depression and anxiety and are an underserved population for mental health services. The purpose of this quality improvement project was to determine if screening caregivers of traumatized children using the Patient Health Questionnaire (PHQ-8) and Generalized Anxiety Disorder (GAD-7) improves identification of depression and anxiety. Participants of this investigation were individuals enrolled in the Children’s Advocacy Services of Greater St. Louis’ 12-week parenting group, TASK (Trauma, Assessment, Skills, and Knowledge). Each participant was asked to complete the PHQ-8 and …
Depression Screening In The Adult Inpatient Oncology Population, Erica Bizub
Depression Screening In The Adult Inpatient Oncology Population, Erica Bizub
Dissertations
Routinely screening oncology patients for depression is recommended due to the higher rates of depression in this population as well as the negative impact of untreated depression. The goal of this QI project is to implement a standard depression screening protocol for patients admitted to this hospital, where there is currently no standard screening protocol. There were 110 patients included in this study, and 67 (60.91%) of patients received a PHQ-9 screening. Of the patients who completed the PHQ-9, 21 (19.09%) had a positive screening, which was a score of seven or higher. While there were high rates of provider …
A Program Evaluation: Insomnia In Adults With Major Depression Disorder With Cognitive Behavioral Therapy For Insomnia (Cbt-I), Taylor E. Wilson
A Program Evaluation: Insomnia In Adults With Major Depression Disorder With Cognitive Behavioral Therapy For Insomnia (Cbt-I), Taylor E. Wilson
Dissertations
Abstract
Problem: In 2023, Compass Health Network (CHN) data analysts found that 91% of CHN patients in the United States who have died by suicide reported problems with sleep, which was the highest risk factor for suicide. The objective of this program evaluation project is to evaluate CHN CBT-I effectiveness on patients ‘suicidality by improving their insomnia.
Methods: CHN quality improvement (QI) project used a quantitative method pre/post score design. Quantitative aggregate data was collected on the participants who met the inclusion criteria via retrospective and prospective chart review prior to CHN implementing the intervention. CBT-I clinicians collected PHQ-9, Columbia-Suicide …
Modulatory Effects Of Flavonoids On Il- 4/Il-13 In Atopic Dermatitis And Their Structure-Activity Relationships, Yueyuan Wang, Jing Liu, Chen Li, Fengfeng Chen, Cheng Yang, Bingtian Zhao
Modulatory Effects Of Flavonoids On Il- 4/Il-13 In Atopic Dermatitis And Their Structure-Activity Relationships, Yueyuan Wang, Jing Liu, Chen Li, Fengfeng Chen, Cheng Yang, Bingtian Zhao
Journal of Food Science and Biotechnology
[Objective ] This study aims to explore the ameliorating effects of flavonoids on atopic dermatitis (AD) and their structure-activity relationships.[Method ] Flavonoids were selected through network pharmacology with interleukin- 4 (IL-4) and interleukin- 13 (IL-13) as key targets.The immunoglobulin E (IgE)-induced RBL- 2H3 cell model was employed to evaluate the effects of flavonoids on inflammatory factors,degranulation activities,and calcium ion influx,and the structure-activity relationships were analyzed.Finally,molecular docking was utilized to assist in exploring the action mechanism.[Result ] All of the six flavonoids (luteolin,apigenin,chrysin,quercetin,kaempferol,and fisetin ) screened by network pharmacology had significant inhibitory effects on the expression of IL- 4,IL- 13,tumor necrosis …