Digital Commons Network^™

Phase 1, First-In-Human, Single-/Multiple-Ascending Dose Study Of Iluzanebart In Healthy Volunteers, Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A Thackaberry, Marco Colonna, Raj Rajagovindan

2020-Current year OA Pubs

OBJECTIVE: To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single- (SAD) and multiple-ascending-dose (MAD) administration.

METHODS: Healthy adult volunteers (N = 136) received intravenous placebo or iluzanebart 1-60 mg/kg (SAD) or 10-60 mg/kg (MAD) followed by serial pharmacokinetics and safety assessments. Safety assessments included adverse events (AEs), vital signs, electrocardiograms, and clinical laboratory evaluations. Pharmacokinetics were assessed through noncompartmental analysis. The study also included open-label cohorts (3, 10, 20, 40, 60 mg/kg SAD; 10, 20, 40 mg/kg MAD) for cerebrospinal fluid (CSF) collection …

Atypical Presentation Of Iars1-Related Disorder: Expanding The Phenotype And Genotype, Parith Wongkittichote, Kira E Jonatzke, Benjamin T Hyde, Lance W Peterson, Mai He, Robert C Mckinstry, Anthony Antonellis, Marwan Shinawi

2020-Current year OA Pubs

Aminoacyl-tRNA synthetases (ARSs) catalyze the formation of aminoacyl-tRNA, which is required for protein translation. A growing number of cases are associated with ARS deficiencies. Pathogenic variants in

Assessing Hypersight Iterative Cbct For Dose Calculation In Online Adaptive Radiotherapy For Pelvis And Breast Patients Compared To Synthetic Ct, Jingwei Duan, Joel A Pogue, Dennis N Stanley, Sui Shen, Natalie N Viscariello, Carlos E Cardenas, Richard A Popple, Joseph Harms

2020-Current year OA Pubs

PURPOSE/OBJECTIVES: Recent technological advancements have increased efficiency for clinical deliverability of online-adaptive-radiotherapy (oART). Previous cone-beam-computed-tomography (CBCT) generations lacked the ability to provide reliable Hounsfield-units (HU), thus requiring oART workflows to rely on synthetic-CT (sCT) images derived through deformable-image-registration (DIR) between the planning CT (pCT) and the daily CBCT. These sCTs are prone to errors stemming from DIR, potentially contributing to dosimetric errors. This study aims to evaluate the capability of direct dose calculation using a novel CBCT platform, HyperSight (Varian-Medical-Systems), as an alternative for sCT.

METHODS/MATERIALS: To validate the HyperSight iterative CBCT (HS-iCBCT) HU accuracy, 125 kV and 140 kV …

Refractive Error And Axial Length (Real) Study: Feasibility Of A Population Study In The United States, Sarah Elizabeth Singh, Lisa A. Ostrin, Kristen L. Kerber, Cayle Concepcion, Celia Gong, Barsha Lal, Ian Flitcroft, Síofra Harrington, James Loughman, Kathryn Saunders, Fuensanta A. Vera-Diaz

Research Outputs: 2025-Present

SIGNIFICANCE: Myopia is the most common eye disease and a leading cause of blindness. A contemporary, large, and ethnically and geographically diverse study of ocular biometry and refractive error in children in the United States is needed to help better describe differences between myopic and nonmyopic eyes. PURPOSE: This is an initial cross-sectional report from the Refractive Error and Axial Length Growth Curve Study that includes ocular component data as a function of age, gender, and geographic location. This feasibility report will inform a planned larger longitudinal ocular growth study in children in the United States. METHODS: Cross-sectional data on …

Cytotoxicity And Surface Area Analysis Of Silver Nanoparticles Encapsulated In Liposomes, Pvp, And Bsa: Effects On Caco-2 And U251 Cells, Rita Byrne, Vinayak Sharma, Bilal Javed, Muhammad Zia Ul Haq, Ahmed Barhoum, Furong Tian

Research Outputs: 2025-Present

No abstract provided.

Roads Of Tomorrow: Augmented Reality For Enhanced Road Maintenance, Nasser Humaid Alshamsi

Theses

The rapid deterioration of roads creates major obstacles that affect public security, urban movement capacity, and economic durability. Standardized road maintenance operations depend heavily on human inspections that prove time-consuming while being labour-intensive and subject to human mistakes. Implementing Augmented Reality (AR) with Point Cloud Data represents a smart approach that improves delivery efficiency in road maintenance procedures for modern cities. AR enables real-time visual content and interactive displays through this research, yet Point Cloud Data delivers detailed, precise road inspections through high-definition three-dimensional mapping. These technologies are evaluated for their usability, effectiveness, and adoption barriers in research that advance …

Determining Sustainable Urban Renewal: A Case Of Quantifying Sustainability For Adaptive Reuse Within Mumbai’S Textile Mill Sector, Arundhati Rajesh Kawlekar

Theses

This study explores adaptive reuse as a sustainable approach to urban development in Mumbai, India, focusing on the revitalization of a heritage textile mill site. It investigates how historical significance and evolving community needs can shape design decisions, while assessing sustainability through Life Cycle Analysis (LCA) and energy efficiency metrics. Mumbai’s defunct textile mills, once central to its industrial growth, now pose challenges to urban vitality. Through a literature review, the paper examines their historical, social, and cultural relevance and the decline of the mill industry. Adaptive reuse emerges as a key strategy to reimagine these structures, offering an environmentally …

Through Legitimate Dissent, The Supreme Court Repairs Itself, Afnaan A. Qureshi

Theses

The decisions of the Supreme Court of the United States, along with its reasoning, influence the direction and scope of historical events. Through an analysis of landmark dissents from four of the worst Supreme Court decisions, Curtis’ dissent in Dred Scott v. Sandford (1857), Harlan’s dissent in Plessy v. Ferguson (1896), Holmes’ dissent in Abrams v. United States (1919), and Murphy’s dissent in Korematsu v. United States (1944), we can take steps towards catalyzing its self repair by stepping away from digital echo chambers and engaging in legitimate dissent. The four cases marked turning points in the efforts to protect …

The Drifter: Creating A Family Archive To Rediscover Lost History, Gabriella Smith

Theses

When history goes undocumented or removed from public access, there is always a question as to how to preserve it. This thesis focuses on the creation of a family archive as a means to preserve and rediscover lost history. When lost history is recovered stories can be completed and we, as a civilization, can gain a better understanding of what our history is. This will be showcased through the creation of the Jerrold Smith Family Archive. Jerrold Smith (1941-1986) a native Rochesterian, grew up with a love of crafts and creating new things. When he passed, he left behind a …

Capturing Community Memory: A Juxtaposition Of Oral History And Historic Building Preservation, Eliot Gavin

Theses

Preserving local history has always been a challenge for small communities. Traditional preservation methods like historic building preservation can be costly and take a lot of time for local historical societies. These historic sites are important to the culture of the local citizens and deserve to be saved. Using The Castle on the Hill in Dansville, New York, as a case study, oral histories will be captured to explore the role of oral history in preservation. The Castle on the Hill plays an important role in shaping Dansville’s identity as a town. In the past, the Castle has served as …

Rooted In Ogdensburg: A Creative Exhibition From Classroom To Gallery, Finn Bishop-Duford

Theses

Picture this: you are an elementary student- wandering around an art exhibition. On the wall hangs artwork you dedicated your time to. How does it make you feel? Art exhibitions of student work are a display practice implemented at the James F. Montpelier Gallery located at Ogdensburg Free Academy in Ogdensburg, New York. Such student-focused art exhibitions, historically, create a wonderful, inspirational, and impactful environment for students to display their finest works. Once the COVID-19 pandemic hit the world by storm in 2020, the thematic shows shifted to assemblages of students’ best work. This is due to the limited time …

Redefining Ritual: Navigating The Intersection Of Transgender And Jewish Identities, Orly R. Wolf

Department of Sociology

Jewish practices vary widely across denominations and individual communities, reflecting diverse cultural influences and interpretations of Jewish law and tradition. For transgender Jews, navigating the intersection of their gender identity and Jewish identity can be challenging, and individuals may struggle to find a community where all aspects of their identity are fully accepted. Studying their narratives and learning from their experiences is vital for understanding how to create spaces that support these intersectional identities.

The purpose of my research is to learn more about the experiences of transgender Jews and how individuals navigate the intersection of their gender identity and …

A Bishnoi Woman’S Odhani: Gendered Labor, Environmental Ethics, And Textile Traditions In Rajasthan, Nidhi Patel

Department of Anthropology

This report examines an embroidered odhani (woman’s shawl) attributed to a Bishnoi artisan from Rajasthan, India. The odhani is housed in the May Weber Ethnographic Study Collection at Loyola University Chicago. Close analysis of technique and contextual evidence is used to reattribute the textile, which was originally mislabeled and situates it within the contexts of gendered labor and environmental ethics within the Bishnoi community. Utilizing the frameworks of materialist and eco-spiritual feminism, the report argues that the odhani functions as a site of ecological resistance, cultural transmission, and women’s embodied knowledge, as well as a garment.

Gdf15 Links Adipose Tissue Lipolysis With Anxiety, Logan K Townsend, Léa J Becker, Jordan G Mccall, Et Al.

2020-Current year OA Pubs

Psychological stress changes both behaviour and metabolism to protect organisms. Adrenaline is an important driver of this response. Anxiety correlates with circulating free fatty acid levels and can be alleviated by a peripherally restricted β-blocker, suggesting a peripheral signal linking metabolism with behaviour. Here we show that adrenaline, the β3 agonist CL316,243 and acute restraint stress induce growth differentiation factor 15 (GDF15) secretion in white adipose tissue of mice. Genetic inhibition of adipose triglyceride lipase or genetic deletion of β-adrenergic receptors blocks β-adrenergic-induced increases in GDF15. Increases in circulating GDF15 require lipolysis-induced free fatty acid stimulation of M2-like macrophages within …

Vascular Rings - What Has Changed, And What Do I Need To Know As A Practitioner?, Sarah Madira, William B Orr, Joshua M Rosenblum, Ryan Pitman, Quang-Tuyen Nguyen, David Molter, Ashley Lloyd, Julie Glickstein, Markus Renno, Pirooz Eghtesady, Jacob R Miller

2020-Current year OA Pubs

Vascular rings represent a heterogeneous set of aberrant great vessel anatomic configurations which can cause respiratory symptoms or dysphagia due to tracheal or oesophageal compression. These symptoms can be subtle and may present at varied ages. More recently, many have been identified in patients without symptoms, including fetal echocardiogram, resulting in a conundrum for practitioners when attempting to determine who will benefit from surgical correction. Here, we provide a review of vascular rings and a guide to the practitioner on when to consider additional imaging or referral. Additionally, we discuss the changing landscape regarding asymptomatic patients and fetal echocardiogram.

The Effects Doctrine: The Simple Answer To The Absurd Results Of Florida's Judicial Interpretation Of Law Enforcement Jurisdiction, Ian A. Wise

Barry Law Review

Imagine the impotence a police officer must feel when watching a dangerous driver coming toward them but being unable to protect the public from harm until that driver crosses the invisible line of a city boundary. Even though hundreds of millions of Americans take preventive measures every day, Florida courts prohibit local law enforcement from doing the same; handcuffing officers by holding they may not take official action the moment they cross over the boundary lines of their city or county.

A narrow set of prudential exceptions to this rule has been created, resulting in absurdly contradictory rulings. Imagine a …

Caught In A Mouse Trap: How Disney V. Desantis Highlights The Difficulties Of Bringing A First Amendment Retaliation Claim Against A State Government, Nicolas Medina

Barry Law Review

The Disney v. DeSantis lawsuit is a product of the current times. Political tensions and animosity between Americans have reached an all-time high. Moreover, it is from these tumultuous times that massive changes can arise. The Disney v. DeSantis lawsuit has highlighted some of the difficulties and challenges modern-day courts face when resolving First Amendment issues in our current political climate. This Article attempts to provide an in-depth understanding of how this lawsuit began, what it is about, how it implicates core American values and ideals, and what new challenges courts might face in future First Amendment litigation.

Part I …

Measuring The Strategies To Cope With Shift Work Among Healthcare Workers, Khushi Mehta, Lindsay Ham

Psychological Science Undergraduate Honors Theses

It is known that lack of sleep, no matter what career a person is in, is detrimental to the overall longevity and health of an individual. Balance of sleep can be easy to attain, especially if one’s work life is able to facilitate it. Healthcare workers, however, often do not have that luxury. Healthcare professionals work a variety of shifts ranging from night shifts, 12-16-hour shifts, regular daytime hours, and being on call during the night. These irregular working schedules can have a detrimental effect on their sleep quality and quantity. If healthcare workers don’t get enough sleep, it can …

5g Network Slice Vulnerabilities And Exploit Chaining Through Enablers, John Breeden

Electronic Theses and Dissertations

Network slicing provides fundamental support for the enhanced features of 5G. Network slicing enablers, such as software-defined networking and network function virtualization facilitate the separation of the physical distributed infrastructures and the functions that create isolated slices. With this framework, the network slice is no longer under the control of a single entity. Multiple infrastructure providers share responsibility for the slice. The 5G architecture derives from multiple services, distributed over great distances, and managed by multiple parties. Each enabler and provider adds vulnerability to network slicing. We examine the interweaving of these enablers to identify vulnerabilities, discuss potential mitigation, and …

"Bad Things Happen In Philadelphia": Managing Stigma And Threats In The Wake Of False Criminal Accusations, Steven Windisch

Sociology and Criminology Faculty Publications and Presentations

In the aftermath of the 2020 U.S. election, the boundary between activism and extremism blurred, with election officials reporting violent threats and false accusations of election fraud. From a symbolic interactionist perspective, these attacks provide a unique lens for examining the consequences of being falsely labeled a criminal. This study utilizes data from in-depth interviews with 15 election officials to explore the nature of informal false accusations, participants' subjective interpretations of these labels, and their behavioral and emotional strategies for managing their "spoiled identity." The findings highlight the criminalizing and dehumanizing effects of these accusations, with officials enduring verbal abuse, …

Nonconformity And Romance: An Analysis Of Pride And Prejudice On Film, Gabriella R. Molseed

Departmental Honors & Graduate Capstone Projects

This paper analyzes how a variety of adaptations, including a selection of traditional and offbeat interpretations, transform the story of Pride and Prejudice through the medium of film and makes a case for how successful each film is as an adaptation. The essay argues that Elizabeth and Darcy’s relationship is formed on a sense of mutual trust between two individuals who reject some aspect of what is expected of them from their society and culture, and any film adaptation must show how Elizabeth and Darcy go against the social norms of the world of their film in their interactions with …

Top Researchers, Scholars Honored With Inaugural Um Awards, Clara Turnage

University of Mississippi News

OXFORD, Miss. – A dozen outstanding faculty members at the University of Mississippi were recognized Tuesday (April 29) at the inaugural Chancellor's Awards for Research and Creative Scholarship.

An Assessment Of The Effects Of Indirect Consultation In Improving Quality Of Life For Adults With Intellectual And Developmental Disabilities, Sarah Michele Russell

Electronic Theses and Dissertations

Seventeen percent of the total population of children are living with an intellectual / developmental disability (IDD), and while resources and therapeutic interventions are accessible during early childhood years, they often cease after turning 21 years old. As a result, many adults with IDD do not acquire the skills necessary to live independently and sustain employment or meaningful relationships, impacting their independence and quality of life. The purpose of this study is to understand how self-management training (in the form of indirect consultation) for adults with IDD influence independence and socially significant behavior in relation to quality of life. The …

Movement Ecology Of Sandhills Chub, A Carolina Endemic, Zachary Adam Ramsey

Electronic Theses and Dissertations

Fish movement studies have traditionally focused on species that support commercial and recreational fisheries, but recently more focus has been given to non-game, stream fishes because of their recognized importance in maintaining biodiversity within these ecosystems. Stream fish movement is described as being “restricted” and following a leptokurtic distribution via diffusive spread related to environmental and biological factors. Many studies of stream fish movement ecology in North America have occurred in high-gradient streams with coarse substrate in mountains or in streams of the interior plains. Sandhills streams of the southeastern USA are characterized as warm-water, low gradient, and dominated by …

Flow Field Surrounding Bluegill (Lepomis Macrochirus) During Suction-Feeding, Jensine Caroline Coggin

Electronic Theses and Dissertations

Suction-feeding is a common method for capturing prey by aquatic organisms and contributed to the diversification of fishes by enabling them to consume a wide range of prey. Suction-feeding is a complex fish-fluid interaction governed by various hydrodynamic forces: inertia, unsteady, viscous, and pressure gradients. These forces are described by the coupling between the flow physics equations (Navier-Stokes) and the dynamic behavior of the fish (motion and forces). However, the distribution of the pressure field that drives this process, and the extent to which suction-feeding is three-dimensional, remain underexplored. I estimated the pressure within the flow field surrounding the mouth …

Heterotopias Of Confinement: Zoo Architecture And The Loss Of Elephant Agency, Clayton Gill Beasley

Electronic Theses and Dissertations

Zoos functions as a site where human-animal relationships are structured through built environments that mediate control and representation. This study examines zoos as heterotopias—spaces where power and surveillance are negotiated between human observers and captive nonhuman animals. While zoos are often framed as spaces of conservation and education, their architectural design reinforces hierarchies of observation and confinement, shaping both human perceptions of nature and the lived experiences of nonhuman animals. This research focuses on Asian elephants as a critical species within this framework, exploring how their captivity illuminates tensions between human-imposed structures and nonhuman autonomy. Drawing from theories of heterotopia, …

End Of Life Care In Pets And What It Tells Us About The Moral Permissibility Of Physician-Assisted Suicide, Paavan Atluri

Philosophy Undergraduate Honors Theses

Our relationships define us. We have different relationships and obligations towards animals based on the societies we live in and the attitudes that individuals choose to have with these animals. People often see themselves as having more moral value than other animals based on the fact that they perceive themselves as having greater intelligence and conscious ability. I think this notion is misguided and the way that people actually perceive moral value is in terms of their relationships with the subject in question. If life was truly perceived in a “more intellect than more moral value” lens then the permissibility …

Implications Of Type Iv Pilus Retraction For Dna Uptake By Acinetobacter Baumannii, Yafan Yu

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Horizontal gene transfer (HGT) via natural competence allows bacteria to incorporate extracellular DNA (eDNA) into their genomes, facilitating genetic diversity and adaptation. In Acinetobacter species, natural competence depends on DNA binding and uptake mediated by type IV pili (T4P). T4P are dynamic extracellular filaments composed primarily of the major pilin subunit PilA, along with a few minor subunits. T4P drive a range of cellular functions including twitching motility, biofilm formation, and DNA uptake, with some functions dependent on pilus retraction and others not. However, how Acinetobacter T4P bind DNA and how T4P/eDNA interactions impact biofilm formation remain unclear. Here, I …

Crisis Response Hospital Physical Layout Considerations During Covid-19: A Framework For Surge Preparedness, Future Investigations, And Analysis, Golnoosh Abdolahzadeh

Durham School of Architectural Engineering and Construction: Dissertations, Theses, and Student Research

This thesis investigates the intersection of hospital design and operational performance during health emergencies, explicitly focusing on layout modifications in emergency departments. The study is structured around four key components. First, it explores hospitals' significant challenges during the COVID-19 pandemic through data collected from interviews with Nebraska hospital leaders. Second, the research introduces a surge-based conceptual framework to guide hospital responses during crisis events. Developed from empirical data, the framework highlights the importance of flexible spatial planning and information-driven decision-making. Third, the study focuses on hospital physical layout considerations, identifying features that either supported or hindered Nebraska hospital operations during …

Modifying The Comb, Rethinking The Install: Integrated Approaches To Honey Bee Colony Establishment And Winter Survival, Shelby A. Kittle

Department of Entomology: Dissertations, Theses, and Student Research

The European, or Western honey bee (Apis mellifera L.) plays a vital role in global ecosystems and agriculture, providing essential pollination services and producing valuable hive products. However, honey bee colony losses have escalated worldwide, but particularly across the United States due to various stressors, including biotic and abiotic factors, mismanagement, and environmental challenges. This thesis investigates key challenges in honey bee management and explores solutions aimed at improving colony health and productivity.

Chapter 1 provides an overview of the beekeeping industry, detailing its economic importance, services, and products, as well as the many challenges faced by beekeepers. It …