Digital Commons Network^™

The Interplay Of Oxidative Stress, Mitochondrial Dysfunction, And Neuroinflammation In Autism Spectrum Disorder: Behavioral Implications And Therapeutic Strategies, Ansab Akhtar, S K. Rahaman

School of Medicine Faculty Publications

Autism spectrum disorder (ASD) deals with several symptoms, including language and speech impairment and developmental delays. The main brain regions affected could be the prefrontal cortex (PFC) or the temporal lobe. The detrimental features could include oxidative stress, mitochondrial dysfunction, and neuroinflammation. Most often, these phenomena are interrelated and can lead to one another, creating a vicious cycle. They also influence the regulation of certain genes involved in the pathogenesis of ASD or related behavior. In the brain regions prone to these detrimental features, a cascade of free radicals, inflammatory cytokines, and mitochondrial energy disruptions is initiated. These actions during …

International Collaboration To Explore Elements For An Effective Residential Childcare Workforce, Justyna Siemionow, Patrick M. Tyler, W. Alex Mason, Deogratias Musoke, Maia Ordonez, Jaime A. Gomez-Blaya, Joseph G. Grzywacz

Faculty Research, Scholarly, and Creative Activity

Residential childcare workers provide critical support to vulnerable children around the world. Building and maintaining a qualified residential childcare workforce is challenged by myriad forces, the foremost of which is recruiting and retaining staff for valuable work often misaligned with available compensation; making individual qualifications at hiring; ongoing training; supervision; and data support systems to monitor performance critical for quality care. This study explored the similarities and differences among these essential elements of staffing across distinct programs: Youth Education Centers (YEC) in Poland, CiudadEscuela Muchachos (CEMU) in Spain, and the Boys Town Family Home Program (BTFHP) in the United States. …

Cognitive Reserve In The Deaf/Hard Of Hearing Community: An Exploration Of Contributing Factors, Olivia B. Allaby

Theses

Cognitive reserve (CR) refers to the individual differences in how people execute tasks, allowing some to cope with cognitive challenges more effectively than others. Additionally, previous studies have established a link between age-related hearing loss and cognitive decline. However, CR and cognitive aging have not been explored extensively in those who might identify as Deaf/hard of hearing (HH). There are four features potentially unique to this community that could shape one’s CR: use of hearing technology (e.g., hearing aid), bimodal bilingualism, and social connectedness and social support. One hundred fifty-nine Deaf/hard of hearing participants completed an online survey study assessing …

An Rna Modification Prevents Extended Codon-Anticodon Interactions From Facilitating +1 Frameshifting, Evelyn M. Kimbrough, Ha An Nguyen, Haixing Li, Jacob M. Mattingly, Nevette A. Bailey, Wei Ning, Howard Gamper, Ya-Ming Hou, Ruben L. Gonzalez, Christine M. Dunham

Department of Biochemistry and Molecular Biology Faculty Papers

RNA post-transcriptional modifications act by stabilizing the functional conformations of RNA. While their role in messenger RNA (mRNA) decoding is well established, it is less clear how transfer RNA (tRNA) modifications outside the anticodon contribute to tRNA stability and accurate protein synthesis. Absence of such modifications causes translation errors, including mRNA frameshifting. By integrating single-molecule fluorescence resonance energy transfer and cryogenic electron microscopy, we demonstrate that the N1-methylguanosine (m1G) modification at position 37 of Escherichia coli tRNAProL is necessary and sufficient for modulating the conformational energy of this tRNA on the ribosome so as to suppress +1 frameshifting otherwise induced …

Differential Mirna Expressions Linking Environmental Risk Factors To Triple-Negative Breast Cancer Stages At Diagnosis, Amjila Bam, Yawen Hu, Xiaocheng Wu, Meng Luo, Nubaira Rizvi, Luis Del Valle, Arnold H. Zea, Fokhrul Hossain, Denise Moore Danos, Jovanny Zabaleta, Augusto Ochoa, Lucio Miele, Edward Trapido, Qingzhao Yu

School of Public Health Faculty Publications

Background/Objectives: Triple negative breast cancer (TNBC) is an aggressive, molecularly heterogeneous subtype of breast cancer, accounting for approximately 10–15% of all cases. While reproductive and metabolic factors contribute to breast cancer development, growing concerns about environmental exposures, alongside biological and socio-cultural influences, underscore the need for targeted prevention strategies across diverse populations. Despite increasing evidence linking biological, socioeconomic, and environmental factors to TNBC outcomes, the molecular mechanisms underlying these relationships remain poorly understood. Micro-RNAs (miRNAs), which regulate gene expression and play critical roles in cancer development, have emerged as potential mediators between environmental exposures and TNBC progression. The goal of …

Gamifying Positive Behavioral Interventions And Supports In A Small Rural School District, Allison Noel

Graduate Student Dissertations, Theses, Capstones, and Portfolios

This case study explored the implementation of a gamified Positive Behavioral Interventions and Supports (PBIS) program in a small rural pre-kindergarten through eighth-grade public school in New England. The study was conducted in response to a significant decline in school climate and staff morale, paired with rising rates of student disciplinary incidents and teacher turnover. Facing unique contextual challenges such as high rates of poverty, adverse childhood experiences, and community-level trauma, the school adopted an innovative approach by embedding game-based strategies into an existing PBIS framework.

Using a qualitative action research methodology, the researcher, also the principal of the school, …

Quality Improvement Project Structured Faculty Mentorship Program: A Quality Improvement Project, Nikki R. Pearson

Doctor of Nursing Practice Projects

The increasing issue of untrained faculty stepping into teaching roles poses a challenge in nursing education. This shift often causes stress and a period of disorientation. One evidence-based solution to enhance role clarity involves mentorship, which is defined as a professional relationship whereby a more experienced faculty member aids in the growth of a novice. The purpose of this project was to help novice nursing faculty by offering them structured, consistent mentorship as they moved into academia. The goal was to increase job satisfaction by clarifying roles, building a sense of support, and ultimately helping to retain faculty. The intervention …

Compact Heterogeneous Architectures And Algorithmic Methods For Enhanced Real-Time Digital True Time Delay Beamforming And Radar Applications, Nathan Lynn Burnett

Theses and Dissertations

Modern radar and signal processing systems require efficient computational architectures to handle increasing data rates while still being able to maintain dynamic configurability and complex tasks. This thesis presents and explores hardware and algorithmic approaches addressing these demands across several different applications. First, a low-cost tracking platform and architecture for unmanned aerial vehicles (UAVs) is developed, which provides detection and tracking capabilities, compliant with new FAA remote ID regulations. Second, a GPU-FPGA based digital true time delay beamformer is implemented to achieve real-time wideband radio frequency interference (RFI) mitigation. Specifically this beamformer explores weight calculation and calibration through particle swarm …

State Parties’ Self-Reported Adherence To Article 31’S Right Of The Child To Play: A Systematic Content Analysis, Richard Smith, Caroline Bond, Francesca Woods

International Journal of Playwork Practice

Article 31 of the introduction of the United Nations Convention on the Rights of the Child (1989) legally protects children’s right to rest, leisure, play, recreation, and cultural and artistic activities. Concerns for the adequate realisation of Article 31 have been longstanding, with the right to play particularly requiring greater attention. This research aims to understand how states are self-reporting right to play observance within the wider context of Article 31 rights. A systematic content analysis was completed with relevant sections of 174 state party reports using Article 31 domains and General Comment 17 factors as an evaluative framework. The …

08.11.2025 Ored Connect, Liz Williamson

ORED Newsletter

F and A rates

ORED Research Reception

NSF Audit Final Resolution and Compliance Updates

The Impact Of Early Life Experiences On Math Confidence, Nhu X. Hin

Master's Theses

Students form beliefs about their academic abilities through a combination of emotional experiences and early learning environments. While prior research has documented how math anxiety can undermine performance and how early experiences with math-typed activities can foster positive attitudes, less is known about how these factors collectively influence students’ math confidence. The present study investigates how math anxiety, engagement in childhood math-typed activities, and perceived support for math-related learning contribute to college students’ confidence in their math abilities. Participants (N = 102) completed self-report measures assessing each of these constructs. A multiple regression analysis revealed that the three predictors collectively …

Impact Of Urban Fine Particulate Matter Exposure On Cardiovascular Health, Shelby P. Briggs

Honors Theses

Air pollution, particularly exposure to fine particulate matter (PM2.5), poses a growing threat to cardiopulmonary health. PM2.5 consists of microscopic particles smaller than 2.5 microns in diameter and originates from industrial combustion, transportation, and urban dust. These particles are classified as xenobiotics and are capable of bypassing respiratory defenses to enter systemic circulation, where they cause oxidative stress, inflammation, and cardiovascular dysfunction. This study examines the effects of PM2.5 on cardiovascular function using a murine model. Male C57BL/6 mice were divided into control (saline), subchronic (10 µg), and chronic (100 µg) groups and were exposed weekly for 11 weeks via …

Tutorial: A Guide To Getting Started With The Clinical Fellowship Experience, Christi Masters, Mariel L. Schroeder

Department of Speech, Language, and Hearing Sciences Faculty Publications

Purpose:

Is Social Media Use A Reason For Socially Withdrawn Individuals' Mental Health Difficulties?, Angela Grundvig

Theses and Dissertations

Studies have found a link between subtypes of social withdrawal and internalizing problems throughout most of the lifespan. However, the work conducted in adolescence is much more limited including a lack of work examining factors that might mediate the association between forms of social withdrawal and internalizing problems. Social comparison may be one way in which social withdrawal predicts internalizing problems. There has been research showing that social media usage is associated with internalizing problems. The purpose of this study was to assess (a) the associations between three subtypes of social withdrawal (shyness, avoidance, and unsociability), respectively, and indices of …

A Novel High-Order Absorbing Boundary Condition For Elastic Multiple Scattering Problems, Jordan Gregory Sheppard

Theses and Dissertations

Elastic waves are waves that propagate by causing deformations in an elastic medium such as metal, rock, or rubber. The main characteristic of elastic wave motion is the coexistence of multiple types of waves at once in the medium, including compressional and shear wave components. This type of motion can be used to study the impacts of physical phenomena such as earthquakes. In this paper, we discuss our research on the time-harmonic scattering of elastic waves in a medium by multiple circular cylindrical obstacles that the wave cannot penetrate. Using the Helmholtz decomposition, we break down the vector-valued physical system …

Neighborhood Socioeconomic Status And Overall Survival Among Children With Acute Lymphoblastic Leukemia, Anna Hoppmann, Debroah M. Hurley, Stuart Cramer, Monique J. Brown Ph.D., Mph

Faculty Publications

A disadvantaged neighborhood, as represented by area-level socioeconomic status (SES) has been associated with adverse outcomes among children with acute lymphoblastic leukemia (ALL) in the US, but the duration of impact after ALL diagnosis is not well understood. This retrospective cohort study utilized the National Cancer Database (NCDB) to examine the impact of area-level SES on overall survival among children with ALL. Median income and education quartiles based on residential zip code were used to create a composite area-level SES variable. Individual-level variables included age, sex, race, year of diagnosis, primary payer, distance to care, rurality, time to treatment, and …

Digital-Based Nutrition Interventions Employing The Dietary Approaches To Stop Hypertension (Dash) Diet: A Systematic Scoping Review, Elizabeth Dodge, Patricia J. Kelly, Basil H. Aboul-Enein

College of Nursing Faculty Papers & Presentations

Background: The Dietary Approaches to Stop Hypertension (DASH) diet is an internationally recognized anti-hypertensive dietary model. This systematic scoping review examines the effectiveness of digital-based interventions utilizing the DASH dietary pattern. Methods: A search was conducted using 14 databases to include relevant studies from 1997 to January 2025 using PRISMA guidelines for scoping reviews. Results: The review included 24 studies with almost 7000 participants, including randomized controlled trials and cohort studies conducted in several countries. Interventions using the DASH dietary pattern positively affected blood pressure (BP), nutrition behavior, and weight. Some studies also reported secondary outcomes such as reduced healthcare …

High Temperature In Potato: Plant Responses And Adaptive Cultivation Strategies To Increase Production, Siska Rahmayani Gultom, Jajang Sauman Hamdani, Kusumiyati

Jurnal Kultivasi

Climate change, with global temperatures rising by 1.09°C from 1850–1900 to 2011–2020, threatens potato production, a critical staple crop, by exceeding the optimal temperature range of 15–20°C. This review synthesizes over 45 peer-reviewed studies published between 2015 and 2025 from Google Scholar and ScienceDirect to evaluate the physiological, morphological, and tuber quality responses of potatoes to high temperatures and to identify adaptive cultivation strategies for sustainable production. High temperatures reduce photosynthetic efficiency through chlorophyll degradation and stomatal closure, increase respiration, and divert photosynthates to vegetative growth, leading to 18–32% yield losses globally by the 2050s. Heat-tolerant varieties, such as Atlantic …

Spontaneous Closure Of A Patent Processus Vaginalis: A Case Report, Haley Kittle, Amber Lee Geng, Loren Berman, Erin Teeple

Department of Surgery Faculty Papers

Introduction: Patent process vaginalis and inguinal hernia are prolific in infants, and their repair is a common pediatric surgical procedure. However, there is a paucity of direct evidence detailing the spontaneous closure of patent processus vaginalis.

Case presentation: A 4-month-old boy born prematurely at 34-weeks with low gestational birth weight, underwent laparoscopic gastrostomy tube placement for oropharyngeal dysphagia and was incidentally found to have bilateral patent processes vaginalis. Due to his lack of symptoms, he was managed under the watchful waiting approach. His parents were educated about signs and symptoms of inguinal hernia and were instructed to contact the team …

Versatile Waveform Generation And Clocking Techniques For Rfsoc-Based Digital Designs, Michael David Jones

Theses and Dissertations

Within an ever-evolving radio-frequency (RF) environment, designers are required to adapt systems to increasingly constricted parameters. The available tools continually grow to match this need, but so does the complexity in using them. The radio-frequency system-on-chip (RFSoC) is an innovation that combines a field-programmable gate array (FPGA) with an integrated RF chain. Designing with an RFSoC allows for high-precision data transmission, sampling, and processing, but it can be difficult and time-consuming to develop specialized circuits. The open-source CASPER project aims to provide a library of abstracted block-design components to simplify the design process. An arbitrary waveform generator (AWG) is created …

“I Feel Like It Gets Worse As I Get Older”: Perspectives Of Peri-Postmenopausal Women With Pcos, Pamela J. Wright Phd, Ms, Med, Rn, Cen, Cynthia F. Corbett, Robin Dawson Phd, Rn, Cpnp-Pc, Faan, Charlotte Burts

Faculty Publications

Introduction:

Polycystic ovary syndrome (PCOS) is a chronic endocrinopathy that transcends the reproductive years. Peri-postmenopausal women with PCOS remain at cardiometabolic risk or subsist with established comorbidity while continuing to contend with persistent PCOS signs and symptoms such as hirsutism. Evidence based information for peri-postmenopausal women with PCOS is scant. The purpose of this qualitative study was to explore the physical, psychosocial, and healthcare perspectives of peri-postmenopausal women with PCOS.

Methods:

Peri-postmenopausal women with PCOS aged ≥43 years (n = 29) were recruited using ResearchMatch to participate in a virtual interview. Interviews were conducted using a semi-structured guide. The …

Botulinum Toxin For The Treatment Of Tremors

Faculty, Staff and Students Publications

Tremor, an oscillatory movement disorder, is commonly encountered in clinical practice in the setting of a variety of etiologies, such as essential tremor and Parkinson's disease. Despite its high prevalence, treatment options are somewhat limited. Oral medications are often ineffective or limited by side effects, and other treatments, such as deep brain stimulation, are more invasive and costly. Botulinum toxin (BoNT) injections are a well-established therapy in the treatment of dystonia, but its use in the treatment of tremors has not been fully explored. In this review, we discuss the available randomized controlled trials and open-label evidence for the use …

Effect Of Potassium Fertilizer On The Nutrition And Physical Quality Of Job’S Tears (Coix Lacryma-Jobi L.) Seeds, Qinthara Nail Haysa, Yuyun Yuwariah, Fiky Yulianto Wicaksono

Jurnal Kultivasi

Job's tears is a cereal crop that has beneficial nutrients. Potassium is known to affect the growth and yield of cereal crops, but there has been limited study on whether potassium affects the nutrition and physical quality of Job’s tears seeds. This study aimed to analyze the effect of K fertilizer on the nutritional content and physical quality of Job's tears seeds. This research was conducted from January to May 2024 at Ciparanje Experimental Field, Faculty of Agriculture, Universitas Padjadjaran, Sumedang, Indonesia. This experiment used the Randomized Block Design (RBD) method with six treatments and four replications. Various doses of …

Deriving Profiles Of Psychosocial Supports And Challenges, And Predicting Longitudinal Trajectories Of Hba1c To Promote Flourishing In Adolescents With Type 1 Diabetes (T1d), Kishan Desai

Electronic Theses and Dissertations Archive

Managing type 1 diabetes (T1D) is emotionally demanding, especially for adolescents navigating intersecting developmental, biological, and psychosocial transitions. Routine psychosocial screening may help address youths’ needs. One hundred eighty adolescents with T1D ages 12-18 (M=14.71, SD=1.69 years) were recruited from a pediatric diabetes clinic. Confirmatory Factor Analyses confirmed a six-factor structure, and Latent Variable Mixture Modeling identified three profiles of psychosocial supports and challenges: (1) Average Supports, Low Challenges (n = 105, 58%), (2) Low Supports, High Challenges (n = 37, 20%), and (3) Average Supports, High Family Conflict (n = 38, 22%). Illness duration and race-income interactions predicted profile …

Statistical Literacy As Health Literacy: The Role Of Emotions In Health Decision-Making, Kendra Murphy

Electronic Theses and Dissertations Archive

Lifestyle-related health problems remain a leading cause of chronic illness in the United States, creating a need for more effective communication of health information. However, the mechanisms that influence how individuals understand and use health information are not yet fully understood. This exploratory study investigates the intersections of statistical health literacy, emotions, and health decision-making from an interdisciplinary perspective. Guided by prior literature suggesting potential relationships among these factors, the study hypothesized that statistical literacy and emotional responses would modify responses to the form of health information presentation, affect the believability and motivational impact of the information, and influence health …

Modeling Dynamic And Static Earthquake-Induced Stress Changes Across Fault And Magmatic Systems: Insights From Finite Element Simulations, Luis Ivan Bazan Flores

Electronic Theses and Dissertations Archive

Earthquakes generate stress perturbations capable of influencing adjacent faults and magmatic systems across a range of spatial and temporal scales. This work investigates how dynamic and static earthquake-induced stress changes affect geological structures in two different tectonic settings: major continental fault systems and subduction zones. The first part of this study examines dynamic rupture interactions between the southern San Andreas Fault and an adjacent normal fault beneath the Salton Sea. Our results indicate that dynamic rupture simulations informed by high-resolution seismic reflection profiles of the normal fault help us uncover the direction of rupture propagation of past events on the …

All In God's Plan?: Examining Positive And Negative Religious Coping As Moderators Of Posttraumatic Stress And Alcohol Use Following Intimate Partner Violence Exposure, Mya Elizabeth Bowen

Electronic Theses and Dissertations Archive

Intimate partner violence (IPV) is defined as physical violence, sexual violence, stalking, or psychological aggression by a current or former intimate partner or spouse (The Centers for Disease Control and Prevention, 2020). Recognized as a pervasive public health concern, approximately 41% of women report experiences of sexual violence, physical violence, and/or stalking, and over 61 million women report experiencing psychological aggression, all at the hands of an intimate partner (Leemis et al., 2022). The pervasive nature of IPV is particularly concerning as experiences of violence can result in significant negative physical and psychological health concerns, including the development of PTSD …

Accelerating Gnn Inference On Multi-Core Systems, Binglin Ji

McKelvey School of Engineering Graduate Student Theses & Dissertations

Graph Neural Networks (GNNs) are becoming increasingly popular, with their applications expanding across diverse domains. As the scale of graph data continues to grow, including larger numbers of nodes, edges, and higher embedding dimensions, standardized libraries such as DGL and PyG have been developed to facilitate GNN computation. However, with the rapid increase in the number of processor cores and the evolution of multi-core architectures, these libraries often show poor scalability and fail to execute GNN inference efficiently on the latest multi-core systems, particularly those with upwards of a hundred cores. To address this limitation, we present FGI, a Fast …

Butte Priority Soils Operable Unit (Bpsou) 2025 Monthly Progress Report. Consent Decree For The Butte Priority Soils Operable Unit. Civil Action No. Cv 89-039-Bu-Seh, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Epitaxial Electrodeposition Of Cu-Btc Metal-Organic Framework Thin Films Onto The (100), (110), And (111) Surfaces Of Single-Crystal Gold And Cuprous Oxide Buffer Layers, Xiaoting Zhang, John Z. Tubbesing, Jay A. Switzer

Chemistry Faculty Research & Creative Works

Metal-organic frameworks (MOFs) have well-defined pore structures. Epitaxial MOFs can produce films with uniform pore sizes and open porosity. However, the growth of epitaxial MOF thin films has remained a challenge. Herein, we demonstrate a cathodic electrodeposition method for the epitaxial growth of a well-known MOF material, copper (II)-benzene-1,3,5-tricarboxylate (Cu-BTC), from solution precursors. The epitaxial electrodeposition of Cu-BTC was achieved in a Cu (NO₃)₂-H₃BTC-H₂O₂ bath using H₂O₂ reduction to deprotonate the H₃BTC molecule. The Cu-BTC films can be grown to micrometer thicknesses with Faradaic efficiencies up …