Digital Commons Network^™

Silvestrol Inhibits Nasopharyngeal Carcinoma Cells And Synergizes With Cx‑5461: Insights From A Proteomics Study, Maelinda Daker, Munirah Ahmad, Alan Khoo, Lu Ping Tan, Siok-Fong Chin, Siaw San Hwang, Paul Neilsen

Department of Medical Oncology Faculty Papers

Nasopharyngeal carcinoma (NPC) is a cancer arising from the epithelial cells of the nasopharynx, which is rare in Western countries but extremely prevalent in Borneo and the Southern China region. Present-day hurdles in NPC treatment that lead to poor quality of life and poor survival include distant metastasis and resistance to chemoradiotherapy. Silvestrol and its 5'''-epimer, episilvestrol, are compounds isolated from the plant Aglaia stellatopilosa, which is endemic to Borneo. Silvestrol, a protein synthesis inhibitor, preferentially inhibits the translation of cancer-associated mRNAs. CX-5461 is an inhibitor of RNA polymerase I that catalyzes rRNA synthesis. The present study sought to …

Improving The Timing To Antibiotic Administration In Patients That Present To The Emergency Department With Sepsis, Adriana Lott, Christina Vejnovich

Group: Nebraska Methodist College

Problem: Early identification and timely management of sepsis in the emergency department (ED) is critical to reducing morbidity and mortality. Delays in sepsis recognition and antibiotic administration can worsen outcomes. This project aimed to address these challenges. Intervention: A triage sepsis screening (TSS) tool was implemented over 30-days to improve sepsis identification at triage. Staff education related to knowledge and confidence of sepsis was also provided. Measures: The impact of a TSS tool was evaluated using pre- and post-intervention data on antibiotic timing. Staff knowledge was measured with a 4-item multiple-choice quiz, and confidence with a 5-item Likert scale, adapted …

Emotional Development In Infancy, Claire Sanford, Samantha Gott

Florida Atlantic Undergraduate Research Journal

Developmental science has documented that infants’ emotional reactions are shaped by individual dispositions and their environment. This study investigated fear responses along with patterns of brain development in infants 6 to 10 months. Nine infant-mother dyads participated, with each infant observed twice (18 visits). An electroencephalogram (EEG) was used to analyze brain activity during resting-state and fear-eliciting conditions. Infant fear vocalizations were evaluated and coded during two conditions, i.e., an unfamiliar object (an electronic toy-spider), and an unfamiliar adult approaching. Results indicated infants’ fear vocalizations were stimuli-specific, with more fear expressed towards approaching strangers than the novel object. Findings also …

Use Of A Novel Plant Essential Oil-Based Insecticide For Insect Control In Household Gardens And Lawns, Mia Michnik, Alysa Suissa, Liah Brussolo Cremona, Annalise Wellman, Nicholas Nifakos, Alexander Spanoudis, John M. Harlin

Florida Atlantic Undergraduate Research Journal

Insecticide use has increased as population and agricultural demand for crops grows. Commercial insecticides contain active ingredients that are often harmful to humans and the environment. A viable alternative to this concern is developing and using insecticides with low toxicity and minimum risk to the environment. In this study, we sought to empirically assess the effectiveness of an insecticide based entirely on plant essential oil active ingredients, which contain complex secondary metabolites. Our results show that a concoction of several plant essential oils was effective in killing a wide range of household garden insect species and bedbugs, encompassing five orders …

Mock Battles: A Time And Place For Conflict, Benjamin Crawford

Florida Atlantic Undergraduate Research Journal

Mock battles are a category of ritual widely recognized by cultural anthropologists, and yet the term as used stands as a wide umbrella covering an incredibly disparate range of human behaviors. Ethnographers have applied the label of “mock battle” both to events incorporating actual bodily harm—most famously, the Andean Tinku—and to non-violent theatrical performances such as the Moros dances popular throughout Spain and Mexico. To better understand the particular social functions of these rituals, I distinguish between two separate but interrelated “genres” of mock battle: the Civil War type, in which communities schedule limited outbursts of cathartic physical violence; and …

Full Issue: Summer 2025

DePaul Magazine

In DePaul Magazine's summer 2025 issue, we celebrate The Theatre School's centennial by asking past and present faculty and administrators and illustrious alumni to comment on the venerable institution's enduring legacy of hands-on learning, collaboration and critical dialogue. Plus, learn about the remarkable relationship between the School of Music and the Chicago Symphony Orchestra that connects music performance students to world-class musicians, see images of campus life snapped by a new student photo agency, and more.

Depaul Digest

DePaul Magazine

College of Communication faculty Matthew Ragas and Ron Culp mentor students on gaining access to executive-level administration. News briefs on exciting developments at DePaul University’s 10 colleges and schools, from nursing students studying public health protocols in Prague to a new DePaul-hosted conference exploring AI in filmmaking. DePaul alumni volunteers share their experiences spreading the Vincentian mission nationwide.

From The President

DePaul Magazine

President Robert L. Manuel shares how the School of Music, The Theatre School and The Art School play an integral role in shaping DePaul's vibrant arts and humanities ecosystem.

Towards Scalable Schema Mapping Using Large Language Models, Christopher Buss, Mahdis Safari, Arash Termehchy, David Maier, Stefan Lee

Computer Science Faculty Publications and Presentations

The growing need to integrate information from many diverse sources poses significant scalability challenges for data integration systems. These systems often rely on manually written schema mappings, which are complex and costly to maintain. While recent advances suggest that large language models (LLMs) can assist in automating schema mapping, key challenges remain. We motivate future research in schema mapping generation by highlighting key challenges, presenting a competitive bidirectional schema matching pipeline, and exploring the limitations of current methods for generating more complex mappings.

Mechanism Of Unconventional Il-33 Release In Airway Disease, Omar Osorio

Arts & Sciences Graduate Student Theses and Dissertations

The alarmin cytokine IL-33 is a strong inducer of type two inflammation and has been implicated in various chronic lung diseases. Although much work has been done to understand the inflammatory effects of extracellular IL-33, there is still a knowledge gap in understanding how this cytokine is secreted by airway epithelial cells in steady-state conditions. In the work laid out in this document, a COPD-disease associated isoform of IL-33, that has exons 3 and 4 (IL-3334) spliced out and is tonically secreted at baseline conditions. This IL-33 isoform is secreted from airway epithelial cells alongside, or as part of, extracellular …

Development Of A New Ground-Based Instrumentation Technique For Low-Resolution Exoplanet Transmission Spectroscopy, Mary Anne Limbach, Luke M. Schmidt, Ryan J. Oelkers, Darren L. Depoy

Physics & Astronomy Faculty Publications

We present a new instrumentation technique for high-precision, ground-based spectrophotometric measurements ideal for low-resolution (R ∼ 20–60) exoplanet transmission spectroscopy. This technique employs novel thin-film coating technology for wide-band, simultaneous multi-band imaging, enabling high-precision differential photometry through self-referencing and comparison stars. Theoretical calculations and on-sky results show that this method effectively reduces 96% of amplitude scintillation noise and other systematics that typically limit ground-based spectrophotometric precision for bright stars. On-sky results are demonstrated using the custom-built Exoplanet Transmission Spectroscopy Imager (ETSI), deployed at the McDonald Observatory 2.1 m telescope in 2022. For a V = 9.7 mag star, ETSI …

Evaluation Of Fano Resonance In Silver Nanotriangles And Complementary Triangular Apertures For Enhanced Refractive Index Sensing, Nabila Islam

Dissertations and Theses

This thesis presents a detailed investigation of plasmonic sensors based on silver (Ag) nanotriangles, focusing on the interaction of plasmonic mode with waveguide modes to achieve Fano resonance for enhanced refractive index sensitivity. For this purpose, Ag nanotriangles were chemically synthesized and were on indium tin oxide (ITO)-coated glass. The samples were illuminated with laser light of various wavelengths and polarization to excite surface plasmon in the nanotriangle. Observation and characterization of their plasmonic behavior was done experimentally using Photoemission Electron Microscopy (PEEM). Numerical simulations using the Finite Element Method (FEM) were performed that agreed with these experimental results and …

Causes Of Symptoms And Symptom Persistence In Long Covid And Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Anthony L Komaroff, Robert Dantzer

Faculty, Staff and Student Publications

Debilitating symptoms for many years can follow acute COVID-19 ("long COVID"), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and various post-acute infection syndromes (PAISs). Together, long COVID and ME/CFS affect 60-400 million individuals, globally. Many similar underlying biological abnormalities have been identified in both conditions including autoantibodies against neural targets, endothelial dysfunction, acquired mitochondrial dysfunction, and a pro-inflammatory gut microbiome. Each of these abnormalities may directly cause some of the symptoms. In addition, the symptoms also may be caused by ancient, evolutionarily conserved symptomatic and metabolic responses to vital threats-sickness behavior and torpor-responses mediated by specific, recently discovered neural circuits. These neural …

Optimizing Motion Management And Baseline Shifts In Magnetic Resonance-Guided Spine Stereotactic Body Radiation Therapy, Yao Ding, Travis C Salzillo, Debra N Yeboa, Martin C Tom, Zhiheng Wang, Parmeswaran Diagaradjane, Ergys Subashi, Jinzhong Yang, Todd Swanson, Thomas Beckham, Chenyang Wang, Amol J Ghia, Tina Briere, Jihong Wang, Fabienne Lathuilière, Sneha Cloake, Eun Young Han

Faculty, Staff and Student Publications

BACKGROUND: Stereotactic body radiation therapy (SBRT) has proven effective in controlling spinal lesions with minimal toxicity, primarily due to its ability to limit spinal cord dose. Recent advances in MR-linac (MRL) technology offer superior spinal cord visualization and real-time gating, which can facilitate dose escalation in spinal tumor treatment while maintaining safety.

PURPOSE: This study aimed to optimize motion management for spine SBRT on an MRL by analyzing patient-specific motion dynamics and evaluating the most effective registration structures. We hypothesized that baseline shifts (BLS) would improve delivery efficiency while maintaining spinal cord dose constraints. The goal was to establish displacement …

Changes In Self-Reported Excessive Daytime Sleepiness Are Associated With 5-Year All-Cause Mortality Risk Among Veterans, Katherine G Bay, Arash Maghsoudi, Amin Ramezani, Drew A Helmer, Amir Sharafkhaneh, Javad Razjouyan

Faculty, Staff and Students Publications

Excessive daytime sleepiness (EDS) is linked to adverse clinical outcomes. This study evaluated changes in a validated tool to assess EDS, the Epworth Sleepiness Scale (ESS) and mortality risk. This retrospective cohort study included Veterans receiving sleep-related services in the Department of Veterans Affairs (VA) from October 4, 1999 to August 18, 2018, with two qualifying ESS measures. ESS values were extracted from patient notes using a validated natural language processing (NLP) pipeline (96% accuracy). ESS scores were categorised as Normal (0-10) or Abnormal (11-24). Patients were grouped based on ESS changes: Normal-Normal, Normal-Abnormal, Abnormal-Abnormal and Abnormal-Normal. Cox proportional hazards …

Computer-Automated Systems And Methods For Using Language Models To Generate Text Based On Reading Errors, Scott Sosso, Siyu Chen, Ciara Figliuolo, Jack Mostow, Marlies Goes

AFIT Patents

A computer-implemented system and method generate personalized text based on statistics derived from input received from a user representing the user's attempts to decode graphemes into phonemes. Such statistics may be measured and recorded at the grapheme-phoneme level, and may include substitutions, insertions, deletions, and correct utterances of phonemes by the user when reading text. A language model may be trained based on characteristics of the user, such as the user's age and/or reading grade level, and the personalized text may be generated after such training of the language model. Generating the personalized text may include generating a text creation …

Revisiting The Effect Of Udenafil On Exercise Performance In Patients With Fontan Circulation: Results Of A Post Hoc Analysis Of The Fuel Trial, David J Goldberg, William B Orr, Et Al.

2020-Current year OA Pubs

BACKGROUND: In the FUEL (Fontan Udenafil Exercise Longitudinal) trial, a positive treatment effect was identified for outcomes at the ventilatory anaerobic threshold but not for the primary outcome, oxygen consumption (Vo

METHODS: Participants were divided into subgroups by baseline predicted peak Vo

RESULTS: Of the 379 participants with paired exercise data, 302 (80%) had a baseline peak Vo

CONCLUSIONS: In this post hoc subgroup analysis, after exclusion of patients with Fontan circulation with near-normal baseline peak Vo

REGISTRATION: URL: https://clinicaltrials.gov; Unique identifier: NCT0274115.

Dna Methylation Signatures Of Cardiovascular Health Provide Insights Into Diseases, Madeleine Carbonneau, Yi Li, Yishu Qu, Yinan Zheng, Alexis C Wood, Mengyao Wang, Chunyu Liu, Tianxiao Huan, Roby Joehanes, Xiuqing Guo, Jie Yao, Kent D Taylor, Russell P Tracy, Peter Durda, Yongmei Liu, W Craig Johnson, Wendy S Post, Tom Blackwell, Jerome I Rotter, Stephen S Rich, Susan Redline, Myriam Fornage, Jun Wang, Hongyan Ning, Lifang Hou, Donald Lloyd-Jones, Kendra Ferrier, Yuan-I Min, April P Carson, Laura M Raffield, Alexander Teumer, Hans J Grabe, Henry Völzke, Matthias Nauck, Marcus Dörr, Arce Domingo-Relloso, Amanda Fretts, Maria Tellez-Plaza, Shelley A Cole, Ana Navas-Acien, Meng Wang, Joanne M Murabito, Nancy L Heard-Costa, Brenton Prescott, Vanessa Xanthakis, Dariush Mozaffarian, Daniel Levy, Jiantao Ma

Faculty, Staff and Students Publications

Background: The association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized.

Methods: We calculated the American Heart Association's Life's Essential 8 score to reflect CVH in 5 cohorts with diverse backgrounds (mean age 54 years, 55% women, and enrollment year ranging from 1989 to 2012). Epigenome-wide association studies (EWAS) for Life's Essential 8 score were conducted, followed by bioinformatic analyses. DNAm loci significantly associated with Life's Essential 8 score were used to calculate a CVH DNAm score. We examined the association of the CVH DNAm score with incident cardiovascular disease (CVD), cardiovascular …

Promising Practices To Address Healthcare Needs Voiced By Local Native Americans, Noelle Taylor, Mykin R. Higbee, Raiden Gaul

Transforming Communities

Purpose

To examine barriers and facilitators to nursing education among Native Americans and identify evidence-based strategies to increase the number of Native American nurses working in their local communities to address health disparities.

Background

Native Americans experience significantly higher rates of chronic illnesses such as diabetes and heart disease, and lower life expectancies. Only 4% of registered nurses identify as Native American, with no growth despite increased funding for diversity in nursing education. This underrepresentation contributes to culturally insensitive care and persistent healthcare inequities stemming from historical marginalization and trauma.

Methods

A comprehensive literature review was conducted using CINAHL, PubMed, …

Penyamaan Persepsi Guru Dalam Pengembangan Mentoring Skills Berbasis Lms Untuk Pembimbingan Mahasiswa Ppl Ppg Prajabatan, Zihan Novita Sari, Herlina Ike Oktaviani, Paundra Wangsa Fajar Kusuma

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Praktik Pengalaman Lapangan (PPL) dalam Pendidikan Profesi Guru (PPG) memiliki peran penting dalam membekali calon guru dengan keterampilan mengajar. Guru pamong memiliki peran penting dengan bertindak sebagai mentor yang membimbing mahasiswa PPL. Namun, terdapat perbedaan pemahaman di kalangan guru pamong terkait konsep mentoring yang menyebabkan ketidakkonsistenan dalam pembimbingan. Oleh karena itu, penelitian ini bertujuan untuk menjabarkan peran Learning Management System (LMS) dalam mendukung pembimbingan mahasiswa PPL PPG, mengidentifikasi tantangan dalam implementasinya, serta memahami persepsi guru pamong terhadap keterampilan mentoring. Penelitian ini menggunakan pendekatan mixed-method dengan desain deskriptif eksploratif. Data dikumpulkan melalui survei dengan angket, wawancara mendalam dengan guru pamong, serta …

“Wild Things Belong Outside”: An Ecofeminist Analysis Of Amy Greene’S Bloodroot, Karrah N. Davidson

Critical Humanities

Appalachian Literature has a canon of its own, one of which I believe Amy Greene’s groundbreaking novel, Bloodroot should be a more prominent part. The novel brings up important cultural as well as universal issues. Situating this work among relevant theory and scholarship allows us to think seriously about the themes that Green explores in the novel in a way that has not been done before. Additionally, I believe that there is important scholarly work to be done with the role of Appalachian Folk Magic in a world where some of these traditions and customs are dying out. Individuals within …

Validity And Reliability Of The 'Feelfit®' Accelerometer In Evaluating Physical Activity And Sedentary Time In Children: A Comparative Study With Two Different Accelerometers, Songdhasn Chinapong, Korntawat Klinchan, Hanif Abdul Rahman, Michael Chia, Waris Wongpipit, Jetsada Arnin, Areekul Amornsriwatanakul

International Journal of Exercise Science

International Journal of Exercise Science 18(2): 794-810, 2025. Accurate physical activity (PA) measurement is crucial for public health surveillance. While self-report questionnaires are commonly used, they have limitations, especially in young children. An affordable and user-friendly device like Feelfit® offers a promising alternative particularly for countries with limited research resources. This study aimed to evaluate Feelfit®’s performance against the widely used ActiGraph® accelerometer in measuring PA among children. A quasi-experimental design was applied. Thirty-nine children (19 boys; 20 girls; aged 11.4 ± 0.5 years) wore both Feelfit® and ActiGraph® during sequentially specified activities of varying intensity ranging from sedentary to …

The Shorthorn: April 29, 1977

The Shorthorn Newspaper Collection: 1970s

No abstract provided.

The Shorthorn: April 26, 1977

The Shorthorn Newspaper Collection: 1970s

No abstract provided.

The Shorthorn: April 27, 1977

The Shorthorn Newspaper Collection: 1970s

No abstract provided.

The Shorthorn: April 21, 1977

The Shorthorn Newspaper Collection: 1970s

No abstract provided.

The Shorthorn: April 20, 1977

The Shorthorn Newspaper Collection: 1970s

No abstract provided.

The Shorthorn: April 15, 1977

The Shorthorn Newspaper Collection: 1970s

No abstract provided.

The Shorthorn: April 14, 1977

The Shorthorn Newspaper Collection: 1970s

No abstract provided.

The Shorthorn: April 13, 1977

The Shorthorn Newspaper Collection: 1970s

No abstract provided.