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Articles 63391 - 63420 of 1824632
Full-Text Articles in Entire DC Network
(Α, Β)-Normal Differential Operators For First Order In Hilbert Spaces Of Vector-Functions, Zameddin I. Ismailov, Pembe İpek Al
(Α, Β)-Normal Differential Operators For First Order In Hilbert Spaces Of Vector-Functions, Zameddin I. Ismailov, Pembe İpek Al
Turkish Journal of Mathematics
In this article, the relationships between (α, β)-normality properties of the extensions of the minimal operator generated by the first-order differential operator expression in the Hilbert spaces of vector-functions in a finite interval and the variable operator coefficients of this differential operator expression are investigated. Then, the general form of all (α, β)-normal extensions of the minimal operator in these spaces is determined under the constraints obtained for the coefficient operators.
On Certain Subclasses Of Starlike And Convex Functions With Respect To T-Symmetric Points, Osman Altintaş, Ni̇zami̇ Mustafa
On Certain Subclasses Of Starlike And Convex Functions With Respect To T-Symmetric Points, Osman Altintaş, Ni̇zami̇ Mustafa
Turkish Journal of Mathematics
In this study, we defined for the first time a new subclass of stalike and convex functions in the open unit disk of the complex plane and we examined coefficiend upper bound estimates for this class.
The Generalization Of Rectifying Helices, Bülent Altunkaya
The Generalization Of Rectifying Helices, Bülent Altunkaya
Turkish Journal of Mathematics
This work establishes connections between different classes of arbitrary speed rectifying helices. We further analyze how the involute of a space curve can exhibit spherical helicity and how the evolute can inherit rectifying properties, thereby providing an alternative characterization of these helices. These relationships, along with their interplay with involutes and evolutes, are supported by illustrative examples that offer deeper insights into their geometric properties.
Applications Of A New Linear Operator Involving Dziok-Srivastava Operator And Bessel Function Of The First Kind, Daniela Andrada Bardac-Vlada, Georgia Irina Oros
Applications Of A New Linear Operator Involving Dziok-Srivastava Operator And Bessel Function Of The First Kind, Daniela Andrada Bardac-Vlada, Georgia Irina Oros
Turkish Journal of Mathematics
This study introduces a new linear operator constructed from the well-known Dziok–Srivastava linear hypergeometric operator, the Bessel function of the first kind, and convolution. Applying the new operator, a class of functions with positive real part is defined and investigated concerning inclusion relations, the necessary and sufficient conditions for functions to belong to this class, as well as starlikeness and convexity conditions. The properties of the new class to be convex of a certain order, close-to-convex and starlike of a certain order are highlighted and examples are also included to prove that the new outcome is applicable. The methods employed …
The Geometry Of Semislant Submersions Whose Total Manifolds Are Locally Conformal Kähler Manifolds, Çağrihan Çi̇men, Hakan Mete Taştan
The Geometry Of Semislant Submersions Whose Total Manifolds Are Locally Conformal Kähler Manifolds, Çağrihan Çi̇men, Hakan Mete Taştan
Turkish Journal of Mathematics
We study semislant submersions whose total manifolds are locally conformal Kähler manifolds. We provide conditions for the total geodesicity and integrability of the distributions involved in the definition. Next, we establish a condition under which such a submersion is a Clairaut submersion. Finally, we obtain some optimal inequalities for a semislant submersion whose total manifold is Hopf space form.
2025 September 12 - Board Of Trustees Agenda And Minutes, Board Of Trustees, East Tennessee State University
2025 September 12 - Board Of Trustees Agenda And Minutes, Board Of Trustees, East Tennessee State University
Board of Trustees Agendas and Minutes
No abstract provided.
2025 September 12 - Academic, Research And Student Success Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University
2025 September 12 - Academic, Research And Student Success Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University
Board of Trustees Agendas and Minutes
No abstract provided.
A Qualitative Exploration Of Child, Caregiver, And Clinician Perspectives On Mental Health In Children With Osteogenesis Imperfecta, Justin H Qian, Andrew D Wiese, Clarissa Gonzalez, Whitney S Shepherd, Hannah Cho, Gianna M Colombo, Julia M Morales, Selena Guo, Kristin M Kostick-Quenet, Dianne Nguyen, Sophie C Schneider, Kara Ayers, Members Of The Bbdc, Marie-Eve Robinson, Chaya N Murali, Brendan Lee, V Reid Sutton, Eric A Storch
A Qualitative Exploration Of Child, Caregiver, And Clinician Perspectives On Mental Health In Children With Osteogenesis Imperfecta, Justin H Qian, Andrew D Wiese, Clarissa Gonzalez, Whitney S Shepherd, Hannah Cho, Gianna M Colombo, Julia M Morales, Selena Guo, Kristin M Kostick-Quenet, Dianne Nguyen, Sophie C Schneider, Kara Ayers, Members Of The Bbdc, Marie-Eve Robinson, Chaya N Murali, Brendan Lee, V Reid Sutton, Eric A Storch
Center for Medical Ethics and Health Policy Staff Publications
Osteogenesis imperfecta (OI) is a heritable connective disorder with clinical manifestations including bone fragility and short stature. Previous research identified psychosocial themes related to mental health among children with OI and their caregivers, such as independence, social isolation, depression, and anxiety. Several studies have also examined clinicians of individuals with OI for their perspectives on mental health among their patients. However, no known studies have compared psychosocial themes among all three participant groups concurrently. This qualitative study examined mood and anxiety, along with risk and protective factors, from perspectives of youths, parents, and clinicians. Semi-structured interviews were conducted, which were …
Wave Intensity Analysis With Exercise Identifies Impairments In Pulmonary Hypertension, Christopher G. Lechuga, Farhan Raza, Mitchel J. Colebank, Claudia E. Korcarz, Jens C. Eickhoff, Naomi C. Chesler
Wave Intensity Analysis With Exercise Identifies Impairments In Pulmonary Hypertension, Christopher G. Lechuga, Farhan Raza, Mitchel J. Colebank, Claudia E. Korcarz, Jens C. Eickhoff, Naomi C. Chesler
Faculty Publications
Wave intensity analysis provides a novel approach to understanding the dynamic interactions between the right ventricle and pulmonary vasculature, particularly in pulmonary hypertension, a condition characterized by elevated pulmonary arterial pressures and vascular remodeling. This prospective study used wave intensity analysis to evaluate right ventricular and pulmonary vascular mechanics in 22 participants with pulmonary hypertension (including precapillary, isolated postcapillary, and combined pre/postcapillary pulmonary hypertension), and three without pulmonary hypertension. Forward and backward compression and decompression waves were quantified at rest and during incremental exercise (25, 50, and 75 W). Relationships between metrics of wave intensity analysis, hemodynamics, right ventricular function, …
Nevus Sebaceous Of Jadassohn With Secondary Cystic Papillary Hidradenoma, Jordan A. Book, Rosemary Prejean, Jonathan M. Joseph, Nicholas Culotta, Christopher Haas
Nevus Sebaceous Of Jadassohn With Secondary Cystic Papillary Hidradenoma, Jordan A. Book, Rosemary Prejean, Jonathan M. Joseph, Nicholas Culotta, Christopher Haas
School of Medicine Faculty Publications
Nevus sebaceous of Jadassohn (NS) is a congenital cutaneous hamartoma that typically presents at birth as a plaque on the face, scalp, or neck. While NS is associated with a risk of neoplastic transformation, the majority of secondary tumors are benign, with the most common being trichoblastomas and syringocystadenomas. In this report, we present a rare case of a 63-year-old male with a right parietal scalp NS with a secondary cystic papillary hidradenoma (HP), which is a benign tumor that almost exclusively occurs in the perineal region. Histopathologic examination was consistent with NS, revealing hyperkeratosis, parakeratosis, increased sebaceous glands, ectopic …
Association Between Climate Change Awareness And Depression & Anxiety: Findings From A U.S. Sample, Stanley Nkemjika, Colvette Brown, Henry Onyeaka, Srikanta Banerjee, Jennifer Oliphant
Association Between Climate Change Awareness And Depression & Anxiety: Findings From A U.S. Sample, Stanley Nkemjika, Colvette Brown, Henry Onyeaka, Srikanta Banerjee, Jennifer Oliphant
Department of Psychiatry and Human Behavior Faculty Papers
BACKGROUND: Exploring the connection between climate change awareness and overall well-being is crucial, particularly in how it impacts both the environment and mental health. The mental health consequences of climate change and its awareness have not been thoroughly examined, especially in the U.S. In this study, the relationship between awareness of climate change and depression or anxiety among U.S. adults was explored. Similarly, the role of climate change awareness has not been explored in relation to mental health concerns.
METHODS: Based on the HINTS-6 dataset, a nationally representative, cross-sectional survey conducted by the National Cancer Institute, a variety of statistical …
Reining In Plasticulture From Land To Sea: Pacific Northwest (Usa) Perspectives On Agriculture And Aquaculture, Susanne M. Brander, Gail A. Langellotto, Minal T. Mistry, Sebastian L. Singleton, Mackenna A. Hainey, Lauren M. Kashiwabara, Kelsey Arthur, Elise F. Granek, Kervelle Baird, Ricardo Palazuelos, Multiple Additional Authors
Reining In Plasticulture From Land To Sea: Pacific Northwest (Usa) Perspectives On Agriculture And Aquaculture, Susanne M. Brander, Gail A. Langellotto, Minal T. Mistry, Sebastian L. Singleton, Mackenna A. Hainey, Lauren M. Kashiwabara, Kelsey Arthur, Elise F. Granek, Kervelle Baird, Ricardo Palazuelos, Multiple Additional Authors
Environmental Science and Management Faculty Publications and Presentations
Plastic use in food production—known as plasticulture—has transformed agriculture and aquaculture globally. Plasticulture gained momentum in the mid-20th century with the development of novel plastic materials, and by 2009, U.S. farmers used over 200 million pounds of plastic films annually. Though plastics have increased yields and efficiency, they now pose environmental hazards through the release of microplastics (MPs) and chemicals. Despite extensive documentation of MPs in the environment, their role in U.S. food production and impacts on crop, livestock, and aquaculture health remain underexplored. In regions like the Pacific Northwest (PNW), with robust agricultural and aquaculture sectors, plastics from films, …
Conference Presentation: 'Ai Disruptions In Higher Education', Cristo Leon Ph.D., James Lipuma Ph.D., Maximus Rafla
Conference Presentation: 'Ai Disruptions In Higher Education', Cristo Leon Ph.D., James Lipuma Ph.D., Maximus Rafla
STEM for Success Resources
Power Point presentation
Investigating How Evolution Has Affected The Neuroanatomy Of Adult Astyanax Mexicanus, Peter Igwilo
Investigating How Evolution Has Affected The Neuroanatomy Of Adult Astyanax Mexicanus, Peter Igwilo
Electronic Theses and Dissertations 2020 - Present
The topology of the brain is highly conserved across phyla, yet the evolutionary processes driving anatomical divergence remain poorly understood. The fish Astyanax mexicanus, which exists in both surface- and cave-dwelling morphs within the same species, provides a powerful model for studying brain evolution. While previous studies have focused on larvae, imaging adult brains has been challenging due to their size and opacity. This study overcame these limitations using tissue clearing, light sheet imaging, and computational analysis to generate a comprehensive adult brain atlas. Using nuclear staining and antibody labeling, brain-wide 3D maps were created to compare regional size, shape, …
Long Development Corp. V. Perez
Long Development Corp. V. Perez
All Decisions
In a nonpayment case, a tenant successfully moved to hold the landlord in civil contempt for violating court-ordered stipulations. The stipulations required the landlord to correct a severe cockroach infestation by implementing **integrated pest management (IPM)** as required by NYC Housing Maintenance Code § 27-2017.8. The court found that the landlord's limited pest control methods—spraying and using traps—were insufficient and constituted disobedience of a clear and unequivocal court mandate. The judge ordered a hearing to determine the tenant's compensatory damages and directed the landlord to immediately begin proper IPM practices.
Hemispheric Asymmetry Of Phase Partition In Mixed-Phase Clouds Based On Near Global-Scale Airborne Observations, Ching An Yang, Minghui Diao, Yang Shi, Xiaohong Liu
Hemispheric Asymmetry Of Phase Partition In Mixed-Phase Clouds Based On Near Global-Scale Airborne Observations, Ching An Yang, Minghui Diao, Yang Shi, Xiaohong Liu
Faculty Research, Scholarly, and Creative Activity
Mixed-phase clouds contribute to substantial uncertainties in global climate models due to their complex microphysical properties. Former model evaluations almost exclusively rely on satellite observations to assess cloud phase distributions globally. This study investigated mixed-phase cloud properties using near global-scale in situ observation data sets from 14 flight campaigns in combination with collocated output from a global climate model. The Southern Hemisphere (SH) shows significantly higher occurrence frequencies and higher mass fractions of supercooled liquid water than Northern Hemisphere (NH) based on observations at 0.2 and 100 km horizontal scales. Such hemispheric asymmetry is not captured by the model. The …
Re: Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 181 – Mountain Con-3 Dump., Mike Mcanulty
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Superhydrophobic Cerium-Based Metal–Organic Frameworks/Polymer Nanofibers For Water Treatment, Samar A. Salim, Hani Nasser Abdelhamid,
Superhydrophobic Cerium-Based Metal–Organic Frameworks/Polymer Nanofibers For Water Treatment, Samar A. Salim, Hani Nasser Abdelhamid,
Nanotechnology Research Centre
No abstract provided.
Strategies To Improve Work–Life Balance Among Remote Millennials To Increase Employee Productivity, Paige Frost
Strategies To Improve Work–Life Balance Among Remote Millennials To Increase Employee Productivity, Paige Frost
Walden Dissertations and Doctoral Studies
A lack of effective strategies to improve work-life balance for remote millennial employees is a concern for healthcare leaders. Without such strategies, organizations may struggle to remain competitive and ensure sustainability. Grounded in Homans’s social exchange theory, this qualitative pragmatic inquiry identified and explored the effective strategies healthcare leaders use to improve work-life balance for remote millennial employees to increase productivity. Participants were six leaders of healthcare organizations located in the southeastern United States with at least 2 years of leadership experience managing remote employees. Data were collected through semistructured interviews and analyzed using Braun and Clarke’s six-step thematic analysis. …
Time And Atmosphere, Mǎdǎlina Diaconu
Time And Atmosphere, Mǎdǎlina Diaconu
Contemporary Aesthetics (Journal Archive)
Phenomenological investigation into atmospheres as spatial feelings has paid little attention thus far to their multifaceted temporality. Ambiances are not only situated but situational; they have an intermittent existence and modify time perception. Certain moods need time to evolve, and prolonged exposure to them may change their character. The passing of time itself generates atmospheres—ages are stereotypically associated with dominant moods, and seasonal rhythms influence well-being. Moreover, ambiances shape epochs and are socially contagious. While the idea that generations can be assigned a prevailing mood is not new, the terms Zeitgeist and Zeitzeichen have been framed by an idealist philosophy …
Nonlinear Stage Of Modulational Instability In Repulsive Two-Component Bose-Einstein Condensates, S. Mossman, S. I. Mistakidis, G. C. Katsimiga, A. Romero-Ros, G. Biondini, P. Schmelcher, P. Engels, P. G. Kevrekidis
Nonlinear Stage Of Modulational Instability In Repulsive Two-Component Bose-Einstein Condensates, S. Mossman, S. I. Mistakidis, G. C. Katsimiga, A. Romero-Ros, G. Biondini, P. Schmelcher, P. Engels, P. G. Kevrekidis
Physics Faculty Research & Creative Works
Modulational instability (MI) is a fundamental phenomenon in the study of nonlinear dynamics, spanning diverse areas such as shallow water waves, optics, and ultracold atomic gases. In particular, the nonlinear stage of MI has recently been a topic of intense exploration and has been shown to manifest, in many cases, in the generation of dispersive shock waves (DSWs). In this Letter, we experimentally probe the MI dynamics in an immiscible two-component ultracold atomic gas with exclusively repulsive interactions, catalyzed by a hard-wall-like boundary produced by a repulsive optical barrier. We analytically describe the expansion rate of the DSWs in this …
Coupled-Channel Calculations Of Fully Differential Cross Sections For Ionization In 75-Kev P + He Collisions, K. H. Spicer, N. W. Antonio, M. S. Schöffler, Michael Schulz, A. S. Kadyrov
Coupled-Channel Calculations Of Fully Differential Cross Sections For Ionization In 75-Kev P + He Collisions, K. H. Spicer, N. W. Antonio, M. S. Schöffler, Michael Schulz, A. S. Kadyrov
Physics Faculty Research & Creative Works
The fully differential cross section is the most detailed quantity that can be measured or calculated to study ionization in few-body systems. For 75 keV proton collisions with helium, various experimental data are available. However, previous theoretical calculations found significant discrepancies across the entire range of data. In this work the wave-packet convergent close-coupling method is extended to calculating these cross sections for electrons ejected with energies from 1 to 75.4 eV. The approach utilizes a two-center expansion and correlated two-electron helium wave functions to describe the four-body proton-helium system. While there is good agreement with the experiment for electrons …
A Picture Paints A Thousand Words: Understanding How People Conceptualise Autism Through Images, Gray Atherton, Emily Dawson, Andrea Piovesan, Lauren Hawksworth-Quill, Liam Cross
A Picture Paints A Thousand Words: Understanding How People Conceptualise Autism Through Images, Gray Atherton, Emily Dawson, Andrea Piovesan, Lauren Hawksworth-Quill, Liam Cross
School of Psychology
Conceptions of autism and neurodiversity vary widely, with differing views on how they are portrayed in contemporary culture. Although autism scholars have long advocated for greater involvement of autistic individuals in knowledge creation, meaningful co-production between autistic stakeholders, researchers, and the broader community remains limited. To explore differences in autism knowledge between autistic and non-autistic people, we used a qualitative method called visual elicitation. We invited the public to upload an image they felt represented autism and explain their choice. Through thematic analysis of these images and their accompanying descriptions, we identified three key themes highlighting how autism is currently …
Bioelectrochemical Systems: Prioritizing Energy Density, Long-Term Stability, And Validation, Luana C.I. Faria, Steffane Q. Nascimento, Filipe C.D.A. Lima, Graziela C. Sedenho, Thiago Bertaglia, Rodrigo M. Iost, João C.P. De Souza, Senentxu Lanceros-Méndez, Shelley D. Minteer, Serge Cosnier, Ariel L. Furst, Frank N. Crespilho
Bioelectrochemical Systems: Prioritizing Energy Density, Long-Term Stability, And Validation, Luana C.I. Faria, Steffane Q. Nascimento, Filipe C.D.A. Lima, Graziela C. Sedenho, Thiago Bertaglia, Rodrigo M. Iost, João C.P. De Souza, Senentxu Lanceros-Méndez, Shelley D. Minteer, Serge Cosnier, Ariel L. Furst, Frank N. Crespilho
Chemistry Faculty Research & Creative Works
Pioneering work in bioelectrochemistry, particularly the employing of yeast cells to generate electrical current, had substantially favored the comprehension of bio electrochemical reactions. This foundational research has boosted the development of bio electrochemical systems (BES), which are significant for sustainable energy solutions. BES technologies, such as biobatteries, bio supercapacitors, and enzymatic and microbial biofuel cells, harness organic and biological systems to provide environmentally friendly alternatives for energy storage and conversion. Despite their potential, these technologies face challenges in achieving competitive energy densities and long-term stability compared to traditional accumulators and converters. Here, we introduce a new Ragone plot for BES, …
Investigating The Effects Of Cognitive Loads On Serial Dependence And Metacognition In Visual Working Memory, Wing Sum Chiu
Investigating The Effects Of Cognitive Loads On Serial Dependence And Metacognition In Visual Working Memory, Wing Sum Chiu
Lingnan Theses (MPhil & PhD)
Humans tend to perceive the physical world based on the input from the recent past, a phenomenon known as serial dependence. Serial dependence typically results in an attractive bias toward prior stimuli to maintain perceptual stability. Nevertheless, it remains unclear whether cognitive loads can modulate serial dependence and metacognitive processes may depend on serial dependence. In this study, we investigate how memory and perceptual loads affect serial dependence, memory precision, and metacognition in visual working memory.
In Experiment 1, we manipulated memory load by varying set sizes. During each trial, 1, 3 or 6 Gabor patches (as a between-subjects factor) …
Spectral–Spatial Transformer With Multiscale Convolutional Attention For Hyperspectral Image Classification, Junde Chen, Wenzhao Li, Hesham El-Askary
Spectral–Spatial Transformer With Multiscale Convolutional Attention For Hyperspectral Image Classification, Junde Chen, Wenzhao Li, Hesham El-Askary
Mathematics, Physics, and Computer Science Faculty Articles and Research
Hyperspectral image (HSI) classification plays a vital role in remote sensing by leveraging rich spectral and spatial information for accurate material recognition. However, existing methods, particularly Transformer-based approaches, still face challenges in effectively modeling multiscale spatial–spectral features, preserving local details, and maintaining robustness to noise. To mitigate these limitations, we propose TMCANet, a spectral–spatial Transformer with multiscale convolutional attention, designed to effectively leverage both local and global contextual dependencies for HSI classification. Our design is guided by three core strategies: first, a convolutional feature extraction module, consisting of four convolutional layers, to learn hierarchical spectral multiscale representations and enhance local …
The Hidden Link Between Hiv And Cardiomyopathy: Unraveling Hiv's Impact On The Heart, Toluwalase Awoyemi, Oluwaremilekun Zeth Tolu-Akinnawo, Andrew Greek, Oluwakemi Adenuga, Chukwuebuka Asogwa, Isaac Ekundayo, Olamide Odusola, Oyinlola Fasehun, Mercy Ajayi, Onyinye Ugoala, Luther-King Fasehun, Adeleke Oluwaseun Dorcas, Michael Angarone
The Hidden Link Between Hiv And Cardiomyopathy: Unraveling Hiv's Impact On The Heart, Toluwalase Awoyemi, Oluwaremilekun Zeth Tolu-Akinnawo, Andrew Greek, Oluwakemi Adenuga, Chukwuebuka Asogwa, Isaac Ekundayo, Olamide Odusola, Oyinlola Fasehun, Mercy Ajayi, Onyinye Ugoala, Luther-King Fasehun, Adeleke Oluwaseun Dorcas, Michael Angarone
Student Publications
This comprehensive review examines the complex relationship between human immunodeficiency virus (HIV) and cardiomyopathy, focusing on the underlying molecular mechanisms, clinical manifestations, diagnostic approaches, and treatment strategies. It highlights the significant global health burden posed by HIV and its potential to cause long-term cardiovascular complications. The review investigates the pathogenesis of HIV-associated cardiomyopathy. It elucidates the intricate cellular and molecular pathways involved, including the actions of neutrophils, monocytes, macrophages, and lymphocytes in cardiac inflammation. Key signaling pathways such as TNF-NF-κB and the caspase-1 inflammasome are detailed, as they contribute to cardiac infection and injury. The clinical manifestations of HIV-associated cardiomyopathy …
The Impact Of A Six Week Exercise And Wellness Intervention For Perceived Stress Of Female Middle School Teachers, Tosha Bell
Doctorate in Kinesiology
The prevalence of classroom-related stress among female middle school teachers is a widely pressing issue with global implications. It is imperative to implement interventions that prioritize the overall health and well-being of these teachers. The primary objective of this randomized control trial was to investigate the incidence of perceived stress within female middle school teachers and the potential role of an exercise and wellness intervention in decreasing perceived stress levels. Nineteen female middle school teachers were randomly assigned to either an intervention group (n=10) or a control group (n=9). The study consisted of a six-week online exercise and wellness intervention …
Carbonation For Enhancement Of Fine Recycled Aggregate Applied To Mortar, Henrique Comba Gomes, Augusto Cesar Da Silva Bezerra, Conrado De Souza Rodrigues, Flavia Spitale Jacques Poggiali, Boksun Kim
Carbonation For Enhancement Of Fine Recycled Aggregate Applied To Mortar, Henrique Comba Gomes, Augusto Cesar Da Silva Bezerra, Conrado De Souza Rodrigues, Flavia Spitale Jacques Poggiali, Boksun Kim
School of Engineering, Computing and Mathematics
Some of the challenges faced by the construction industry related to sustainability are the generation of construction and demolition waste (CDW), environmental impacts caused by the demand for natural aggregates, and associated carbon (CO2) emissions. One potential solution is recycling CDW as recycled aggregates (RA). Though, RA generally performs poorly compared to natural aggregates (NA) in concretes. Researchers suggest that CO2 curing via accelerated carbonation may improve the properties of RA. However, further investigation is needed to understand the impact of CO2 curing on mortar made with fine recycled aggregates (FRA). This study explores the effects …
Resolution Of Physics And Deep Learning-Based Protein Engineering Filters: A Case Study With A Lipase For Industrial Substrate Hydrolysis, Spencer Gardiner, Peter Dollinger, Filip Kovacic, Jörge Pietruszka, Daniel Ess, Karl-Erich Jaeger, Gunnar F. Schröder, Dennis Della Corte
Resolution Of Physics And Deep Learning-Based Protein Engineering Filters: A Case Study With A Lipase For Industrial Substrate Hydrolysis, Spencer Gardiner, Peter Dollinger, Filip Kovacic, Jörge Pietruszka, Daniel Ess, Karl-Erich Jaeger, Gunnar F. Schröder, Dennis Della Corte
Faculty Publications
Computational enzyme design remains a powerful yet imperfect tool for optimizing biocatalysts, especially when targeting non-natural substrates. Using design tools we investigated Pseudomonas aeruginosa LipA, a lipase with a flexible lid domain crucial for substrate binding and turnover, aiming to enhance its hydrolysis of the industrially relevant substrate Roche ester. We generated an initial set of single-point mutations based on structural proximity to the active site and evaluated their effects using a computational pipeline integrating molecular dynamics (MD) simulations, density functional theory (DFT) calculations, and ensemble-based energy scoring. While we identified several active variants, attempts to rank them by activity …