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Novel Insights Into Wdfy3 Pathogenicity: A Case Report Of Microcephaly And Epilepsy, Pietra Spinardi, Gabriel Bordignon, Gustavo Moura Da Mata Machado Ferreira Pinto, Monica Alexandra De Conto, Daniel Almeida Do Valle

Journal of Pediatric Genetics

WDFY3 is a critical gene involved in neuronal migration, autophagy, and vesicular transport during brain development. Pathogenic variants in WDFY3 gene are associated with a range of neurodevelopmental disorders, including autism spectrum disorder ASD, epilepsy, and intellectual disability. We present here a case of a female child with a de novo heterozygous WDFY3 variant (c.10189A>T; p.Thr3397Ser), identified through whole exome sequencing. The patient presented with microcephaly, global developmental delay, and epilepsy. Despite the presence of microcephaly, neuroimaging (MRI) revealed no significant abnormalities, a finding consistent with previous reports. Previous studies suggests that WDFY3 haploinsufficiency alters synaptic density and mitochondrial …

Diagnosis And Initial Tratment Of Gorham-Stout’S Disease, Jesús González Cayón, Maria Del Carmen San Basilio Berenguer, Julio César Moreno Alfonso, Santiago De La Puente Pérez, Paloma Triana Junco, Juan Carlos López Gutiérrez

Journal of Pediatric Genetics

The Gorham-Stout’s disease, also known as massive osteolysis or evanescent bone disease; is an extremely rare disease characterized by a proliferation of intraosseous lymphatic channels causing progressive osteolysis. Usually, surgery, sclerotherapy and radiotherapy have been reserved for local and symptomatic control of the disease, while medical treatments have presented variable results that are not entirely satisfactory according to literature. The recent identification of germline-activating somatic mutations in the PIK3CA gene has opened the way to treatment with mTOR inhibitors, being Sirolimus an effective option with a low incidence of serious adverse effects. We present a patient diagnosed with GSD and …

Unraveling The Etiology Of Childhood Hypotonia Using Exome Sequencing, Arya Shambhavi, Amita Moirangthem, Rajesh Kumar Maurya, Varunvenkat M. Srinivasan, Haseena Sait, Somya Srivastava, Renu Suthar, Shubha R. Phadke

Journal of Pediatric Genetics

This cohort study of 48 unrelated probands with rare monogenic childhood hypotonia was designed to assess the clinical presentations, spectrum of disorders, and utility of exome sequencing in selected cases where preliminary genetic tests did not sufficiently explain the etiology. Clinically 56.3% of the cases appeared to be of peripheral hypotonia, 33.3% cases were of central hypotonia, and remaining 10.4% were mixed hypotonia cases. Exome sequencing was able to provide a diagnosis in 52.1% cases in the entire cohort of rare monogenic childhood hypotonia. Majority (41.6%) of the probands had a clinical diagnosis of congenital myopathy/muscular dystrophy in the cohort …

Long-Term Survival In Lung Cancer With Brain Metastases And Coronary Artery Stenosis: A Case Report, Raghad O. Alharbi, Shahad J. Alshammary, Nasser E. Alotaibi, Ruba M. Aljohani, Bader A. Alotaibi, Ihab F. Suliman

Journal of the Saudi Heart Association

Lung cancer is among the most diagnosed cancers worldwide, and its co-occurrence with coronary heart disease is life-threatening. Osimertinib is the standard treatment for epidermal growth factor receptor (EGFR) mutations in advanced non-small cell lung cancer (NSCLC). The addition of pemetrexed and carboplatin increases not only the efficacy but also the cardiotoxicity risk. We report a 59-year-old woman with NSCLC alongside brain, liver, and spleen metastases, who developed cardiovascular events following cancer therapy. With advanced imaging and multidisciplinary intervention, remarkable remission was achieved over two years. Reporting this case contributes to the understanding of its presentation and diagnostic challenges.

Rethinking Service Learning: Reciprocity And Power Dynamics In Community Engagement, Jason Wollschleger, Mark Killian, Kayla Prewitt

Journal of Community Engagement and Higher Education

This article seeks to challenge existing power dynamics both within the service-learning classroom and between the classroom and community by offering a model of an alternative approach to community engagement. The class partnered with a community organization, at their request, to engage their community as the organization worked through a change in focus and identity. Within the classroom, the research project was led, designed, implemented, and ultimately written solely by the students.

“I Am So Resilient Right Now”: Impact Of The Life Skills Journey Summer Program On Métis Program Leaders, Alicia Hibbert, Fay Fletcher, Brent Hammer

Journal of Community Engagement and Higher Education

The authors present the impact of the Métis Settlements Life Skills Journey facilitator training program. Community members, aged 16 to 32, were hired and trained to lead youth summer camps. It was hypothesized that participation in the program and employment as facilitators would have a positive impact on their individual resilience. The program and employment were designed to increase participant knowledge in key areas of resilience and skills to engage chil-dren in learning through play.

Building Community One Structure At A Time: A Partnership Between Social Work And Landscape Architecture Students, Kenya M. Cistrunk, Elizabeth P. Tofte, Juriel A. Rogers

Journal of Community Engagement and Higher Education

Experiential learning is invaluable when promoting interdisciplinary approaches to teaching complex issues. This article reports on a five-week collaboration between undergraduate stu-dents in social work and landscape architecture courses, project impetus being a common-reading text. Students (n=54) constructed three-dimensional models of children’s playgrounds and prepared academic posters describing restorative interventions based on their service-learning experiences with community partners. Projects were displayed at university-sponsored workshops. Participation in common reading programs has promising implications for interdis-ciplinary collaboration.

Sharing A Vision With An International Partner Through Photographs, Leah S. Dunn, Diane Ceo-Difrancesco, Rakhi Srivastava

Journal of Community Engagement and Higher Education

The purpose of this study was to establish a shared vision between the academic program and the international service-learning partner. Through the use of photovoice (Collier & Collier, 1986), we conducted a needs assessment to determine the partner’s priorities. Analysis of inter-view transcripts and photos yielded themes representing the partner’s needs and were the basis of the shared vision, adding clarity to the purpose of the experience.

Helping Persons Experiencing Homelessness Complete Advance Directives: A Model For Service Learning Within A Community-Academic Partnership, Woods Nash, Sandra J. Mixer, Polly M. Mcarthur, Annette Mendola, Kylie Jackson, Caroline Darlington, Bruce Spangler, Merrell Pressley, Erin Conley

Journal of Community Engagement and Higher Education

Despite their interest in completing advance directives (ADs), persons experiencing homeless-ness (PEH) appear to have fewer surrogate decision-makers and limited opportunities for ad-vance care planning (ACP). Nursing students and faculty, a hospital bioethicist, and social ser-vice agency staff formed a community-academic partnership that helps PEH complete advance directives. This unique service-learning opportunity offers a model for assisting vulnerable pop-ulations with advance care planning. Model effectiveness and limitations are described from each partner’s perspective in their own words.

Video Analysis For Software Regression Detection Using Generative Models, Shu-Wei Cheng, Andy Huang, Megha Joshi, Juan Borgnino, Yoga Sadasivam, Oscar Ding, Jessica Hua, Zening Li, Fei Wang, Kamakshi Kodur

Defensive Publications Series

Identifying software regressions and user experience issues in complex applications from video recordings can present a challenge for certain quality assurance methods, which may be inefficient for analyzing long video sessions. The disclosed technology can use a large generative artificial intelligence model to perform a granular, for example, minute-by-minute, analysis of video recordings captured from an application's user interface. This system can process extended video streams to detect potential visual and functional anomalies, such as incorrect camera behavior, faulty user interface callouts, or inferred voice guidance errors. Use of this method may help to automate the identification and reporting of …

Healing On The Homefront: Convelescent Homes In England During Wwi, Elizabeth Rogerson

Montview Journal of Research & Scholarship

This paper explores the response to soldiers needing rehabilitation in World War One and how convalescent facilities impacted the everyday lives of injured men, nurses, and military medicine. During the Great War, there was an influx of the diversity of injuries due to the expanse of biological and machine warfare. Recognizing that field hospitals were insufficient, England’s War Office executed a plan to requisition public facilities and use volunteer forces not only to heal English men but soldiers from across the world. This paper establishes the context for the convalescing system in England and then its accommodation and improvisation for …

Nonlinear Analytical Models Of The Seismically Isolated ``Frame-Boiler'' System With Cantilever-Type Hysteresis Dampers, Aleksandr Mikhailovich Anushchenko, Dmitrii Evgenievich Bondarev, Aleksandr Yurievich Schukin

Journal of Sustainable Construction Materials and Technologies

This study shows results of development of the ``frame-boiler'' system with hysteresis dampers analytical model. Hysteresis dampers are used as boiler antiseismic bracing. It is noted that simplified analytical models are necessary at the stage of preliminary iterative calculations, when a CAE-modeling is impractical due to significant time costs. The authors have proposed 2 options of analytical models: 2-mass model and 3-mass model. The differential equations of motion for each model are written below. The results of the calculation for seismic impacts are compared with the finite element model. It is shown that 3-mass model gives good match of results …

Advancing Sustainable Structural Solutions: Hemp Fiber-Reinforced Polymer (Hfrp) Reinforcement Bars For Concrete Applications Through Material Selection, Simulation, And Pathways For Future Development, Thomas Cadenazzi, Busra Keles

Journal of Sustainable Construction Materials and Technologies

This paper investigates innovative Hemp Fiber-Reinforced Polymer (HFRP) rebars as a sustainable alternative to conventional Carbon Steel (CS) and Glass Fiber-Reinforced Polymer (GFRP) rebars used as reinforcement in concrete structures. The feasibility of HFRP rebars is assessed, focusing on mechanical properties and sustainability advantages. A virtual tensile test on a modeled M19 HFRP rebar, conducted using Autodesk's Fusion 360, demonstrates tensile strength comparable to CS 235 and greater environmental sustainability than GFRP, despite a slight reduction in stiffness. The study also considers the potential of graphene fiber integration to enhance mechanical properties, underscoring HFRP's adaptability. Findings suggest that HFRP rebars, …

An Online Scientific Twitter World: Social Network Analysis Of #Sciencetwitter, #Scicomm, And #Academictwitter, Man Zhang, Lisa Lundgren, Ha Nguyen

Instructional Technology and Learning Sciences Student Research

Understanding who makes up online affinity spaces as well as how information flows within those spaces is important as more people access news, research topics, collaborate with others, and entertain themselves. During a month-long period in summer 2021, we collected 100,000 tweets from 53,311 Twitter users who used the hashtags #ScienceTwitter, #SciComm, and #AcademicTwitter. We then classified users and determined the type of social network they formed. Scientists, the public, and educators formed this affinity space. They built connections by initiating activities and interacting with others, which created a Community Clusters social network structure, characterized by several medium-sized groups of …

Molecular Biophysics And Engineering Lab, University Of Mississippi. School Of Engineering

University Website Migration from WordPress

Molecular Biophysics sits at the crossroads of biology, chemistry, physics, and engineering—and is rapidly transforming how we understand life. Our lab focuses on the cytoskeletal machinery of the cell, aiming to uncover how molecular components work together to drive essential cellular processes. We study how motor proteins, crosslinkers, and cytoskeletal filaments coordinate to perform complex tasks like cell division, movement, and muscle contraction. By combining cutting-edge biophysical tools—including optical trapping, fluorescence microscopy, and QCM-D—we explore how these molecular interactions scale up to support the functions of living systems. This foundational knowledge helps reveal the fundamental design principles that govern living …

The Expanded Regulatory Significance Of Saharan Dust Plumes In The United States, Paul Miller, Kimberly Hamilton-Wims, Ken Holmes, Doug Melancon, Jason Meyers, Tegan Treadaway

Faculty Publications

Given the recent reduction in the U.S. National Ambient Air Quality Standard (NAAQS) for annual PM2.5from 12 to 9 μg m^–3, the contribution of exceptional, though natural, particulate transport events has assumed greater regulatory relevance. This study examines the evolution of a June 2022 trans-Atlantic Saharan dust outbreak and contextualizes its impact on the 2023 PM2.5design values (DVs) for continental U.S. air quality monitors. The results demonstrate that the intrusion of Saharan dust yielded mean 24 h PM2.5values > 35 μg m^–3for multiple days across the Central U.S. and single-handedly elevated the 2022 mean annual PM2.5by > 0.5 …

Karma Feels Good After Being Unfairly Excluded, Jordan Karnbach

University of Mississippi News

OXFORD, Miss. – Call it karma, schadenfreude or any number of other terms, but nearly everyone has taken joy at someone else's misfortune, especially if the victim had snubbed others.

The Effect Of Moringa Oleifera Leaves Powder Increasing The Productive Characteristics Of Common Carp (Cyprinus Carpio L.) Exposed To Chlorpyrifos, Hamid Hilal Farhan, Abid Ali Thaker, Hazem Sabri Abedalhammed

Baghdad Science Journal

Pesticides are a major global problem because of their effects on living organisms and their bodily functions. This study was conducted from August 25, 2022, to October 25, 2022. It aimed to know the toxic effects of Chlorpyrifos on common carp (Cyprinus carpio L.), and the potential of Moringa oleifera leaves to reduce this toxicity by evaluating their effect on growth performance in fish exposed to the pesticide. The LC50 for Chlorpyrifos has been estimated at 0.60 mg/L over 96 hours. Use 1/10 of the LC50 in the pesticide toxicity test treatment; Moringa leaf powder (MOL) was also added …

Synthesis And Characterization Of Eu-Substituted Bismuth-Based Superconductors Via Chemical Sol-Gel Method, Firas Salim Abed, Lamia K. Abbas

Baghdad Science Journal

The study seeks to investigate the role of Eu substitution in improving the characteristics of bismuth-based superconductors, employing the sol-gel technique as a flexible synthesis methodology. The study is focused on superconductor samples of the composition Bi_1.7-xPb_0.3Eu_xSr_1.9Ba_0.1Ca2Cu3O_10+δ, where x ranged from 0.0 to 0.5 through systematic investigation where the Pb and Ba are maintained at fixed values 0.3 and 0.1 respectively. The influence of partially substituting Eu for Bi on superconducting characteristics was thoroughly explored. Electrical resistivity measurements unveiled a notable enhancement in critical temperature (Tc) with …

Evaluating Climate Sensitivity To Atmospheric Co2 In Basra, Baghdad And Mosul: Iraq, Dalia A. Mahmood, Luma M. Al-Saadi, Monim H. Al-Jiboori

Baghdad Science Journal

Iraq has been suffering from a rising surface air temperature (SAT), causing a general deterioration in ecosystems. Climate sensitivity (CS) which refers to the increase in average SAT caused by a duplication of Carbon Dioxide Concentration [CO₂], was estimated by transient local climate response (TLCR) and equilibrium local CS (ELCS). The time series of the spatial annual averages for both [CO₂] and air temperature were analyzed and a linear regression model was also used to find annual trends in SAT and [CO₂]. Based on historical yearly data for CO₂ concentrations (2003–2016), CO_{2 …}

Evaluating The Mechanical Properties Of Maxillofacial Silicone Enhanced By Hexagonal Boron Nitride Particles, Montather S. Ali, Faiza M. Abdul-Ameer

Baghdad Science Journal

Maxillofacial silicone is the most popular and commonly used material for the construction of maxillofacial prostheses. However, the material failed to satisfy the expected features of a maxillofacial prosthesis due to major limitations, particularly in mechanical properties. The goal of this study is to evaluate the mechanical properties of the VST-50F silicone elastomer with the addition of hexagonal boron nitride (H-BN). A total of 120 specimens were prepared and divided into three groups control and two experimental (0.5 wt% and 0.7 wt% H-BN). Each group was divided into four identical subgroups. For each subgroup, 10 specimens were utilized for each …

06. Thermodynamics Of Phase Transitions Ii, Gerhard Müller

Equilibrium Statistical Physics

Part six of course materials for Statistical Physics I: PHY525, taught by Gerhard Müller at the University of Rhode Island. Documents will be updated periodically as more entries become presentable.

Updated with version 2 on 1/8/2026.

Draft Final Butte Mine Waste Repository Geotechnical Investigation Work Plan, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Consumer Behavior-Based Strategies Small Business Leaders Use To Increase Online Sales Revenues, Alexander Sakharov

Walden Dissertations and Doctoral Studies

Many small business leaders struggle to tailor online strategies that drive demand, limiting growth and differentiation in competitive digital markets. Business leaders must adopt data-informed, customer-centered approaches that align digital marketing efforts with consumer behavior and market expectations. Grounded in social exchange theory, the purpose of this qualitative pragmatic inquiry was to explore the online shopping marketing strategies that some small business marketing leaders use to increase demand for products and services. Data were collected through semistructured interviews with six small business leaders from Vancouver, British Columbia; Toronto, Ontario; and Seattle, Washington. The four main themes identified using thematic analysis …

A New Home For Special Collections Instruction, Michele Jennings

Marian Library Blog Archive

A special collections classroom in Roesch Library offers exciting opportunities for teaching and learning with UD Libraries' rare and unique collections.

Overcoming Variable Illumination In Photovoltaic Snow Monitoring: A Real-Time Robust Drone-Based Deep Learning Approach, Amna Mazen, Ashraf Saleem, Kamyab Yazdipaz, Ana Dyreson

Michigan Tech Publications

Snow accumulation on photovoltaic (PV) panels can cause significant energy losses in cold climates. While drone-based monitoring offers a scalable solution, real-world challenges like varying illumination can hinder accurate snow detection. We previously developed a YOLO-based drone system for snow coverage detection using a Fixed Thresholding segmentation method to discriminate snow from the solar panel; however, it struggled in challenging lighting conditions. This work addresses those limitations by presenting a reliable drone-based system to accurately estimate the Snow Coverage Percentage (SCP) over PV panels. The system combines a lightweight YOLOv11n-seg deep learning model for panel detection with an adaptive image …

Beyond Personal Responsibility: Government Support For The Substantive Human Condition, Martha T. Mccluskey

Contributions to Books

Government protection against systemic harm to human well-being is stymied by the liberal idea that power is most legitimately wielded by autonomous individuals taking personal responsibility for their substantive well-being. Instead, a robust vision of democracy and socioeconomic justice requires grounding legitimate power in institutional responsibility, replacing the formal individual actor of liberal theory with the universally embodied, embedded human subject developed in Martha Fineman’s Vulnerability Theory. This chapter connects the message of personal responsibility in neoliberal US welfare reform policies to rationales defending the government’s failure to alleviate systemic human harm in the 2008 financial crisis and the accelerating …

Nonfinancial Factors Shape Food Insecurity Among U.S. Older Adults, Madonna Harrington Meyer, Colleen M. Heflin

Population Health Research Brief Series

Nonfinancial factors such as poor physical and mental health, lack of access to healthy food, and transportation challenges make it more difficult for older adults to obtain, prepare, and consume healthy food. Based on the book, Food for Thought: Understanding Older Adults Food Insecurity, this brief summarizes how nonfinancial factors function as both causes and consequences of food insecurity in old age.

Debt Accumulation In Fossil Fuel-Reliant Localities During The Shale Boom And Implications For The Energy Transition, Brandon Charles

Center for Policy Research

The energy transition away from fossil fuels poses long-term economic risks for communities reliant on oil and natural gas production and some may face exceptionally difficult challenges in adapting to the change. Bonds issued by these localities during the shale boom may undermine their financial resilience as shale activity dwindles. Declining tax revenue may undermine their ability to service the debt and maintain the associated physical assets. This study addresses the extent to which local governments in oil- and natural gas-producing communities accumulated significantly more municipal debt during the shale boom than other communities. The analysis uses bond issuance data …

Dilemmas Encountered While Planning Social And/Or Political Elementary Mathematics Tasks, Amanda Sugimoto, Simon Byeonguk Han, Courtney Koestler, Eva Thanheiser, Mathew Felton-Koestler, Molly Robinson

Mathematics and Statistics Faculty Publications and Presentations

A mathematical task rooted in social and/or political contexts has the potential to engage students in exploring their own real-ities and learning about the realities of others while building their mathematical knowledge. While there are planning and in-structional practices recommended for these types of tasks, no single practice can fully capture the nuances and challenges thatteachers might encounter. Therefore, this study identified dilemmas encountered by a team of mathematics education research-ers while planning a mathematical task rooted in social and/or political contexts. Using qualitative analysis, the researchersidentified three planning dilemmas: (a) what social and/or political goal to establish, (b) how …