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Downwind-Upwind Flux Path Analysis Method For Model Reduction Performance Evaluations, Christian Robert Smith Oct 2025

Downwind-Upwind Flux Path Analysis Method For Model Reduction Performance Evaluations, Christian Robert Smith

Theses and Dissertations

Large, complex chemical kinetic models have long since been limited by the computational cost it takes to evaluate said model. Over time many reduction methods have been developed to combat this computational cost. However, very little has been done towards evaluating the limitations of reductions as a way of understanding the original model’s characteristics. This paper aimed to use a path flux analysis-based reduction algorithm to rapidly develop multiple reduced mechanisms for a 96 species FFCM-2 methane chemical kinetic model as well as an 858 species n-Dodecane chemical kinetic model. The goal of formulating these reduced mechanisms was to identify …


New Approaches On Source Coding For Quantum Stochastic Sources And Implementation Of Quantum Fanout Gate, Rabins Wosti Oct 2025

New Approaches On Source Coding For Quantum Stochastic Sources And Implementation Of Quantum Fanout Gate, Rabins Wosti

Theses and Dissertations

The accurate computation of advanced quantum algorithms like Shor’s integer factorization, quantum phase estimation (QPE), and the quantum Fourier transform (QFT) requires quantum circuits of considerable size and depth. It is difficult to achieve reliable computation with deep quantum circuits due to the limited coherence times of the current noisy quantum devices. The quantum fanout gate is known to be a powerful primitive for reducing the depth of many quantum circuits (Høyer and Špalek 2003; Gottesman and Chuang 1999). Shallow or constant-depth quantum circuits are desirable for both near-term and fault-tolerant quantum computations as they reduce noise and allow faster …


Multiphysics Modeling, Analysis, And Design Of Ceramic Hollow Fiber Membranes For Oxygen Separation, Hamed Abdolahimansoorkhani Oct 2025

Multiphysics Modeling, Analysis, And Design Of Ceramic Hollow Fiber Membranes For Oxygen Separation, Hamed Abdolahimansoorkhani

Theses and Dissertations

Oxygen plays a central role in numerous industrial processes. Several technologies have been reported for producing oxygen from air. Among them, oxygen transport membrane (OTM) technology—based on mixed-conducting, gas-tight ceramic membranes—has attracted significant attention due to its high oxygen selectivity, relatively low capital and operating costs, and versatility for both ex-situ and in-situ applications. Mathematical modeling of OTMs offers a powerful tool to investigate internal multi-physics transport phenomena, providing deeper insight into fundamental mechanisms while serving as a cost-effective approach for optimizing membrane stack designs.

After a comprehensive introduction, in the first part of this dissertation (chapter 2), a comprehensive …


Implicit Neural Representation For Image Reconstruction, Canyu Zhang Oct 2025

Implicit Neural Representation For Image Reconstruction, Canyu Zhang

Theses and Dissertations

Image reconstruction seeks to restore corrupted images and recover visual content that has been lost or degraded. Such degradation may result from low resolution, occlusion, masking, or shadow interference. This problem has become an increasingly significant research topic, as visual information plays a central role in almost every aspect of modern life. Neural network based approaches have recently emerged as highly effective solutions for this task. In particular, convolutional neural networks and transformer based architectures have demonstrated remarkable success in producing visually convincing reconstructions. However, these models remain constrained in several important ways, one of the most critical being that …


Identifying And Understanding The Barriers To Sexual Health Information Seeking Experienced By Young Adults (Ages 18-26) Using Social Media, Alexander Nicolas Vera Oct 2025

Identifying And Understanding The Barriers To Sexual Health Information Seeking Experienced By Young Adults (Ages 18-26) Using Social Media, Alexander Nicolas Vera

Theses and Dissertations

This dissertation uses a qualitative, constructionist approach to examine the sociotechnical and cultural dynamics that shape digital sexual health-seeking practices of young adults. Guided by information practices and affordance theory, the research draws on semi-structured interviews and digital walkthroughs with 20 young adults (ages 18–26) from a convenience sample of young adults residing in South Carolina. Participants described how they use platforms like TikTok, Instagram, and Reddit not only to locate information but to assess its trustworthiness, inclusivity, and personal relevance in real time. Through in-depth accounts and screen-based demonstrations via digital walkthroughs, the study examines how participants engage in …


Recognizing The Unexpected: Deep Learning Across Complex Environments, Ge Song Oct 2025

Recognizing The Unexpected: Deep Learning Across Complex Environments, Ge Song

Theses and Dissertations

Ensuring the security, trustworthiness, and operational integrity of modern autonomous and cyber-physical systems presents a critical challenge. While widely utilized in various engineering applications, such as intelligent transportation and industrial manufacturing, these systems require robust monitoring frameworks to identify unexpected anomalies in real-time, thereby maintaining operational safety and efficiency. This dissertation develops advanced deep learning methodologies for anomaly detection and health monitoring, with a particular emphasis on semisupervised reconstruction-based approaches that identify anomalies in complex environments using models trained only with normal operational patterns.

Building on this theme, the first study focuses on analyzing pedestrian behavior and detecting anomalies at …


Evaluating The Performance And Feasibility Of A Device-Agnostic Approach To Compare Raw Accelerometry And Hr Data From Consumer Wearables To Research Grade Devices In Young Adults, Candy Bryan Mrudula Yalla Oct 2025

Evaluating The Performance And Feasibility Of A Device-Agnostic Approach To Compare Raw Accelerometry And Hr Data From Consumer Wearables To Research Grade Devices In Young Adults, Candy Bryan Mrudula Yalla

Theses and Dissertations

INTRODUCTION: Wearable technologies are increasingly used to monitor physical activity and heart rate in both research and everyday settings. This study aimed to compare accelerometery and heart rate (HR) data from two consumer wearables Apple Watch Series 7 and Google Pixel Watch Series 2, with research-grade devices: the ActiGraph GT9X Link and ActiHeart 5.

METHODS: Twenty-four young adults aged 18–24 years (mean age = 22.4; 54.2% female) participated in a 90-minute activity protocol while wearing the devices. The protocol included structured tasks ranging from rest to vigorous intensity. Consumer wearables and ActiGraph were worn on the non-dominant wrist, and the …


Calculating Surface Current Velocities From Video Generated From A Near Forward-Facing Camera, Colby James Weeks Oct 2025

Calculating Surface Current Velocities From Video Generated From A Near Forward-Facing Camera, Colby James Weeks

Theses and Dissertations

This work presents a camera system for estimating surface currents. A combined camera and IMU system provide high resolution images and high precision orientation information, respectively. This eliminates the need for leveling and enables forward looking operation. The hardware stack includes a Lucid Vision Triton TRT162S monochrome camera, an SBG Ellipse D with dual antenna GNSS for precise pose, and an Nvidia Jetson Orin for acquisition and processing. The Ellipse D provides a hardware trigger at 10 Hz to time stamp each frame and to synchronize images with inertial measurements.

A camera calibration step estimates the intrinsic camera parameters and …


Computational Analogies In The Era Of Large Language Models, Amarakoon Mudiyanselage Thilini Wijesiriwardene Oct 2025

Computational Analogies In The Era Of Large Language Models, Amarakoon Mudiyanselage Thilini Wijesiriwardene

Theses and Dissertations

Analogical reasoning is an important part of human cognition requiring the integration of abstract reasoning, pattern recognition, and background knowledge. Despite significant advances in language modeling, the capacity of current methods to accurately identify, model, and evaluate analogies remains fundamentally underexplored.

Analogies enable individuals to perceive deep similarities between superficially different situations. Effective analogy-making requires integrating knowledge about the external world with abstract reasoning and pattern recognition capabilities. While current language models (LMs), trained on massive textual corpora using autoregressive or masked objectives, achieve impressive performance across Natural Language Processing (NLP) tasks such as text generation, summarization, and classification, their …


Multi-Layer Decision Making For Long-Term Autonomous Mission Based On Dual Process Theory, Shruti Jadhav Oct 2025

Multi-Layer Decision Making For Long-Term Autonomous Mission Based On Dual Process Theory, Shruti Jadhav

Theses and Dissertations

Unmanned aerial vehicles (UAVs) are increasingly used in precision agriculture, where extended autonomous operation is required for monitoring, intervention, and field management. However, achieving long-term autonomy remains challenging due to battery constraints, environmental uncertainty, and the need to balance exploration with event-driven tasks. To address these challenges, a multi-layer decision-making framework inspired by Dual Process Theory (DPT) is developed. The framework combines reactive return-tobase strategies, exploratory navigation, and directional bias from prior missions, with a conflict-monitoring mechanism that adapts system behavior based on real-time conditions. The approach is implemented in a simulated agricultural grid environment, demonstrating improved adaptability and coverage …


Reduced Order Simulator Of A Nuclear Thermal Propulsion System, Jackson Taylor Zazzaro Oct 2025

Reduced Order Simulator Of A Nuclear Thermal Propulsion System, Jackson Taylor Zazzaro

Theses and Dissertations

This thesis presents the development of a reduced-order simulator for a nuclear thermal propulsion (NTP) system, designed to capture the key thermo-fluid and performance characteristics of such systems while maintaining computational efficiency. The primary objective of this work is to develop and demonstrate a modular simulation framework capable of modeling the coupled physics of an NTP reactor, nozzle, and orbital transfer system. The simulator integrates a reduced-order thermal-fluid model of the reactor, a simplified nozzle model, and an orbital transfer model, providing a comprehensive yet computationally efficient representation of the propulsion process. By employing reduced-order modeling techniques, the simulator achieves …


Multi-Perspective Feature Learning For Facial Expression Recognition In The Wild, Xiangyu Hu Oct 2025

Multi-Perspective Feature Learning For Facial Expression Recognition In The Wild, Xiangyu Hu

Theses and Dissertations

With the rapid progress of deep learning, Facial Expression Recognition (FER) has seen substantial improvements in performance, particularly “in the wild” meaning real world conditions. Despite these advances, most existing methods extract features from facial images as the sole emotional cues, which limits the model’s ability to capture the full complexity of human emotional expressions.

In reality, facial expressions are composed of diverse and multi-perspective information, including appearance-based cues and geometric structural deformations due to activations of facial muscles. Depending exclusively on one type of representation may fail to exploit the complementary nature of these cues, an issue that becomes …


October 2025 Library News, University Libraries Oct 2025

October 2025 Library News, University Libraries

Library News

No abstract provided.


Exploring Barriers To Patient Care In A South Carolina Free Clinic, Jonathan G. Green Oct 2025

Exploring Barriers To Patient Care In A South Carolina Free Clinic, Jonathan G. Green

Doctor of Nursing Practice Scholarly Projects

Access to healthcare remains a persistent challenge for medically underserved populations who rely on free medical clinics for primary care services, particularly in non-Medicaid expansion states such as South Carolina. Free clinics serve as critical safety-net providers, yet patients frequently encounter barriers that limit access, continuity, and quality of care. The purpose of this Doctor of Nursing Practice (DNP) project was to explore and identify the structural, social, and interprofessional barriers to patient care within a South Carolina free medical clinic to inform targeted, evidence-based interventions. A mixed-methods needs assessment design was used, combining a retrospective chart review of forty …


Combating Obesity: Creating A Comprehensive Wellness Plan For Uninsured & Low-Income Populations, Kayla C. Berrios Oct 2025

Combating Obesity: Creating A Comprehensive Wellness Plan For Uninsured & Low-Income Populations, Kayla C. Berrios

Doctor of Nursing Practice Scholarly Projects

Aim: The aim of this project was to research the specific barriers encountered by obese patients that are low-income and uninsured. The goal of this data collection was to inform the stakeholders involved in creating a comprehensive wellness plan for obese patients.

Background: The staff at Good Neighbor Clinic have struggled to support their support their obese patients with weight reduction. Many of the ailments that patients seek care for correlate to their obesity. Health promotion in this community clinic needs a more comprehensive program to support patients during their weight loss experience, providing support and resources to allow for …


Empowering Mothers: A Digital Intervention For Perinatal Mental Wellness, Morgan Edmunds Oct 2025

Empowering Mothers: A Digital Intervention For Perinatal Mental Wellness, Morgan Edmunds

Doctor of Nursing Practice Scholarly Projects

Aim: The aim of this project was to develop a smartphone application prototype for peripartum mental health. The goal of this application was to enhance access to education and quality mental health care.

Background: Currently, in the United States, peripartum mental health conditions are the leading cause of maternal morbidity and mortality (The Joint Commission, 2023). There is a gap in education, screening, and treatment for peripartum mental health due to distrust and a lack of resources, including a lack of mental health providers (Dossette et al., 2024; Feldman & Perret, 2023). Therefore, there is a significant number of women …


Learning Opportunities 2025/2026, Illinois Math And Science Academy Oct 2025

Learning Opportunities 2025/2026, Illinois Math And Science Academy

Course Catalogs

The graduation requirements of the Illinois Mathematics and Science Academy are established by the IMSA Board of Trustees. Each semester students must take a minimum of five academic courses (2.5 credits) for a letter grade (not Pass/Fail) not including SIR, Internship, Credentials and Independent Study. Students may enroll in a maximum of seven courses each semester including academic courses, SIR, Internship, Credentials, and Independent Study. The College and Academic Counselor approves enrollment for students in all courses and experiences. Academic courses must be taken for a grade in order to count towards graduation credit.


Check Out The Library, 2025 Fall Issue, Cal Poly Humboldt Library Oct 2025

Check Out The Library, 2025 Fall Issue, Cal Poly Humboldt Library

Library Publications

Issue 20


A Modified Fama-Macbeth Model Based On The Single-Index Model, Mariam Jumaah Mousa, Munaf Yousif Hmood Oct 2025

A Modified Fama-Macbeth Model Based On The Single-Index Model, Mariam Jumaah Mousa, Munaf Yousif Hmood

Journal of Economics and Administrative Sciences

The aim of this essay is to use a single-index model in developing and adjusting Fama-MacBeth.  Penalized smoothing spline regression technique (SIMPLS) foresaw this adjustment.  Two generalized cross-validation techniques, Generalized Cross Validation Grid (GGCV) and Generalized Cross Validation Fast (FGCV), anticipated the regular value of smoothing covered under this technique. Due to the two-steps nature of the Fama-MacBeth model, this estimation generated four estimates: SIMPLS(FGCV) - SIMPLS(FGCV), SIMPLS(FGCV) - SIM PLS(GGCV), SIMPLS(GGCV) - SIMPLS(FGCV), SIM PLS(GGCV) - SIM PLS(GGCV). Three-factor Fama-French model—market risk premium, size factor, value factor, and their implication for excess stock returns and portfolio returns—were estimated on …


Sinclair Lewis Society Newsletter, Vol 34, No. 1, The Sinclair Lewis Society Oct 2025

Sinclair Lewis Society Newsletter, Vol 34, No. 1, The Sinclair Lewis Society

Sinclair Lewis Society Newsletter

“Every Time Something Big and Stupid Happens in America, Lewis Becomes Popular Again”: A Conference Retrospective, with Notes from a First-Time Visitor to Sauk Centre by Shaun F. Richards

Pickerbaugh’s Rhymes: Another Target of Satire in Arrowsmith by George Killough

In Memoriam: Robert E. Fleming, Father of the Sinclair Lewis Society by Sally E. Parry

Arrowsmith 100 years later: Osterholm Links Lewis’s Novel to Modern Society by Shalon Wilber

Becoming A Writer: A Review of Writers Like Us: My Life with Sinclair Lewis, by Barnaby Conrad, with Barnaby Conrad III by Shaun F. Richards

Sinclair Lewis and the Pulitzer …


A Comparison Of Return To Sport After Bankart Repair Versus Latarjet For Shoulder Instability: A Systematic Review, Claire E Noyes, Grace E Johnston, Nicholas Vaver, Patrick M Garvin, Jonathan T Bravman, James W Genuario, Braden K Mayer, Thomas J Noonan, Carson Keeter, Eric C Mccarty Oct 2025

A Comparison Of Return To Sport After Bankart Repair Versus Latarjet For Shoulder Instability: A Systematic Review, Claire E Noyes, Grace E Johnston, Nicholas Vaver, Patrick M Garvin, Jonathan T Bravman, James W Genuario, Braden K Mayer, Thomas J Noonan, Carson Keeter, Eric C Mccarty

Faculty, Staff and Student Publications

Background: Glenohumeral instability can be addressed surgically with repair of the capsulolabral complex, the "Bankart" repair, or bone augmentation with coracoid autograft, the "Latarjet" procedure. Superior return-to-sport (RTS) rates with either Bankart repair or Latarjet have yet to be delineated, and it remains unclear which surgical procedure is optimal.

Purpose: To review the current literature and report on RTS data for patients who received Bankart repair or Latarjet to address glenohumeral instability.

Study design: Systematic review; Level of evidence, 4.

Methods: This systematic review and meta-analysis was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines …


Sulforaphane And Non-Clustered Tumor/Non-Tumor Suppressor Micrornas Regulate Akt And Its Downstream Genes In Mda-Mb-231 Cancer Cells, Omobolanle David Garuba Oct 2025

Sulforaphane And Non-Clustered Tumor/Non-Tumor Suppressor Micrornas Regulate Akt And Its Downstream Genes In Mda-Mb-231 Cancer Cells, Omobolanle David Garuba

Dissertations (2016-Present)

Cancer is a complex pathological condition characterized mainly by uncontrolled rapid cell divisions caused by several factors, which include genetics and environmental factors. Of all cancer types, breast cancer (BC) remains the second most diagnosed among women worldwide; thus, BC burden has become a global health issue. Of all known breast cancer subtypes, triple-negative breast cancer (TNBC) is the only primary subtype without effective therapy as a result of their lack of the essential estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) common to other BCs and are the usual therapeutic targets for treatment. …


Detection Of Microplastics In Household Dust From Suburban Texas And Toxicological Assessment Of Polystyrene Microparticles In Lung Epithelial Cells: Nf-Kb Pathway Activation And Inflammatory Responses, Nirupama Surubhotla Oct 2025

Detection Of Microplastics In Household Dust From Suburban Texas And Toxicological Assessment Of Polystyrene Microparticles In Lung Epithelial Cells: Nf-Kb Pathway Activation And Inflammatory Responses, Nirupama Surubhotla

Dissertations (2016-Present)

Microplastics are emerging contaminants that have raised global concern due to their persistence, ubiquity, and potential impacts on human health. Indoor environments are increasingly recognized as significant sources of microplastic exposure through household dust inhalation. This study aimed to detect the presence of microplastics in household dust from suburban regions of Texas, USA, and to investigate the cytotoxic and inflammatory effects of polystyrene microparticles in a lung epithelial cell model (A549). Household dust samples were collected and analyzed using Raman spectroscopy, confirming the presence of a mixture of microplastics. To assess biological responses, A549 cells were exposed to defined sizes …


University Of San Diego Magazine Fall 2025, Publications Department Oct 2025

University Of San Diego Magazine Fall 2025, Publications Department

University of San Diego Magazine (1992- )

Beauty, Goodness and Truth; Dear Toreros; Around Alcalá Park; At The Edge of It All; Faith In Action; Torero Spotlight; Torero Athletics; Toreros Making Waves; In Memoriam; Leading With Love


Mitochondrial Haplogroups, But Not Heteroplasmy, Are Associated With Midlife Cognitive Function, Kristine Yaffe Oct 2025

Mitochondrial Haplogroups, But Not Heteroplasmy, Are Associated With Midlife Cognitive Function, Kristine Yaffe

Faculty, Staff and Student Publications

Introduction: Mitochondrial DNA (mtDNA) variation may influence cognitive performance, but prior findings are inconsistent.

Methods: We analyzed data from 2308 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study, assessing heteroplasmy (mtHz) burden and haplogroups (mtHg) from blood-derived mtDNA at three timepoints and cognitive function across multiple domains. Multivariate linear regression models and multivariate linear mixed models adjusted for age, sex, education, and race.

Results: MtDNA heteroplasmy burden and count were not associated with cognitive performance. However, mtHgs in macro-mtHg L were linked to poorer cognitive outcomes, particularly in processing speed and global cognition in cross-sectional and …


Peritoneal Immunosurgery: Immunotherapy Augmented Surgery For The Treatment Of Peritoneal Cancers, Malcolm K Brenner, Alastair M Thompson Oct 2025

Peritoneal Immunosurgery: Immunotherapy Augmented Surgery For The Treatment Of Peritoneal Cancers, Malcolm K Brenner, Alastair M Thompson

Faculty, Staff and Students Publications

Peritoneal malignancy often indicates disruptions in multiple physiological systems resulting from widespread cancer. The heterogenous origin and dynamic nature of peritoneal cancer make it difficult to treat with standard approaches that fit into guidelines. We describe how successful treatment should address the underlying pathology, the systemic response to surgical treatments and target the immune perturbations that facilitate the establishment and propagation of this multifaceted disease.


Using Latent Patient-Centered Fear Extinction Profiles To Guide Treatment In Pediatric Ocd, Brent J Small, Sabine Wilhelm, Joseph F Mcguire Oct 2025

Using Latent Patient-Centered Fear Extinction Profiles To Guide Treatment In Pediatric Ocd, Brent J Small, Sabine Wilhelm, Joseph F Mcguire

Faculty, Staff and Students Publications

Background: While exposure with response prevention (ERP) is the frontline treatment for pediatric obsessive-compulsive disorder (OCD), not all patients benefit. Impairments in extinction learning are implicated in pediatric OCD's etiology and treatment, with impaired pre-treatment extinction learning associated with worse ERP outcomes. However, available methods for assessing patients' difficulties with fear extinction are costly and underdeveloped. In response, we used person-centered profiles to characterize latent fear extinction patterns among youth with OCD, and investigated the degree to which scores on common rating scales correspond to profile membership.

Methods: Youth with OCD (n=98) completed a diagnostic clinical battery followed by a …


Examining The Relationship Between Dysphagia, Eating-Related Symptoms, And Diet Quality Among Oropharyngeal Cancer Patients During Critical Stages Of Cancer Survivorship: The U-Dine Study, Shreela Sharma, Ruosha Li, Emily Roller, Andrew Bevelhimer, Katherine A Hutcheson, Marcia C De Oliveira Otto Oct 2025

Examining The Relationship Between Dysphagia, Eating-Related Symptoms, And Diet Quality Among Oropharyngeal Cancer Patients During Critical Stages Of Cancer Survivorship: The U-Dine Study, Shreela Sharma, Ruosha Li, Emily Roller, Andrew Bevelhimer, Katherine A Hutcheson, Marcia C De Oliveira Otto

Faculty, Staff and Students Publications

Background: Diet quality is a modifiable factor impacting treatment outcomes in oropharyngeal cancer (OPC), yet the effect of dysphagia and self-reported eating-related symptoms remains unclear. This study examined their associations with diet quality in OPC patients.

Methods: A cross-sectional analysis was conducted with two parallel cohorts from MD Anderson Cancer Center and Michael E. DeBakey Veterans Affairs Medical Center as part of the Uncovering the Long-Term Impact of OPC and Dysphagia on Dietary Quality and Nutrition Among Cancer Survivors (U-DINE) Study. Participants at varying survivorship stages (prediagnosis, 3-6 and 18+ months posttreatment) were assessed for dysphagia (DIGEST scale) and six …


Lac-Phe Induces Hypophagia By Inhibiting Agrp Neurons In Mice, Yao Liu, Cunjin Su, Hueyxian Wong, Na Yin, Hesong Liu, Xing Fang, Kristine M Mcdermott, Hueyzhong Wong, Meng Yu, Longlong Tu, Jonathan C Bean, Yongxiang Li, Mengjie Wang, Yue Deng, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Junying Han, Megan E Burt, Sanika V Jossy, Chunmei Wang, Yongjie Yang, Benjamin R Arenkiel, Dong Kong, Yang He, Jonathan Z Long, Yong Xu Oct 2025

Lac-Phe Induces Hypophagia By Inhibiting Agrp Neurons In Mice, Yao Liu, Cunjin Su, Hueyxian Wong, Na Yin, Hesong Liu, Xing Fang, Kristine M Mcdermott, Hueyzhong Wong, Meng Yu, Longlong Tu, Jonathan C Bean, Yongxiang Li, Mengjie Wang, Yue Deng, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Junying Han, Megan E Burt, Sanika V Jossy, Chunmei Wang, Yongjie Yang, Benjamin R Arenkiel, Dong Kong, Yang He, Jonathan Z Long, Yong Xu

Faculty, Staff and Students Publications

Lactate-derived N-lactoyl-phenylalanine (Lac-Phe) was recently identified as an lactate-derived circulating metabolite that reduces feeding and obesity, but mechanisms that underlie the metabolic benefits of Lac-Phe remain unknown. Here we demonstrated that Lac-Phe directly inhibits hypothalamic neurons that express Agouti-related protein (AgRP), resulting in an indirect activation of anorexigenic neurons in the paraventricular nucleus of the hypothalamus (PVH). We also found that both AgRP inhibition and PVH activation are required to mediate Lac-Phe-induced hypophagia. Further, we show that Lac-Phe inhibits AgRP neurons via activating the ATP-sensitive potassium (KATP) channel, and inhibition of the KATP channel blunts effects of Lac-Phe to suppress …


Impact Of Meditation Device Use On Quality Of Life Of Patients Following Surgery For Hypercortisolism, Bahar Bahrani Fard, Malavika Suresh, Rashi Sandooja, Bahaa H Salama, Vanessa Fell, Elizabeth J Atkinson, Sara J Achenbach, Irina Bancos Oct 2025

Impact Of Meditation Device Use On Quality Of Life Of Patients Following Surgery For Hypercortisolism, Bahar Bahrani Fard, Malavika Suresh, Rashi Sandooja, Bahaa H Salama, Vanessa Fell, Elizabeth J Atkinson, Sara J Achenbach, Irina Bancos

Faculty, Staff and Students Publications

Context: Patients with endogenous hypercortisolism experience glucocorticoid withdrawal syndrome (GWS) after surgery. Meditation may be an effective intervention to alleviate the severity of GWS.

Objective: To determine the acceptability of a portable, wearable electroencephalography device for guided meditation (MUSE headband) and the impact of MUSE use on GWS and quality of life 12 weeks postsurgery.

Methods: We conducted a single-center prospective cohort study of adults with endogenous hypercortisolism undergoing curative surgery from 2019 to 2024. Patients had baseline and postsurgical assessments over 12 weeks. The study comprised patients using MUSE for ≥ 6 weeks (MUSE cohort) and patients matched by …