Digital Commons Network^™

Self-Assembling Rna Nanostructures Are Highly Sensitive To Environmental Conditions, Jordan Aposhian, Surya Pratap S. Deopa, Scott Horowitz, Joseph D. Yesselman

Chemistry and Biochemistry: Faculty Scholarship

Recent developments in RNA nanotechnology have led to an increase in the design of specific, higher-order RNA structures, which will ultimately be used in drug delivery and immunomodulation applications. As researchers create RNA nanostructures with the intention of making them a standard tool in molecular biologists' toolkits, further investigation is required into the robustness of RNA designs. Primarily, in what different molecular contexts are the designed and intended nanostructures stable? In this work, we show that RNA nanostructure self-assembly is highly sensitive to environmental conditions by using second-order right-angle light scattering. While a test RNA hexagonal grid nanostructure forms correctly …

Mind The Gap: Intergenerational Perspectives On Mental Illness Within Ghanaian American Communities, Ama Danso-Ayesu

Electronic Theses and Dissertations

This research explores attitudes toward mental illness among Ghanaian immigrants and

first-generation Ghanaian Americans, with particular focus on factors that influence

stigma. Guided by Bronfenbrenner’s Bioecological Model, the study utilized the

Community Attitudes Toward Mental Illness (CAMI) Scale to measure four dimensions

of stigma, including authoritarianism, benevolence, social restrictiveness, and community

mental health ideology. A comparative, cross-sectional design was employed to examine

differences between immigrant and American-born participants. The findings revealed

generational differences where Ghanaian immigrants reported higher levels of

authoritarian and socially restrictive beliefs, while first-generation Ghanaian Americans

demonstrated more benevolent and inclusive attitudes. Interpreted through the ecological

systems …

Examining The Effects Of Video Modeling To Enhance Culturally Specific Social Greeting Skills In Preschoolers With Asd In Saudi Arabia, Sarah Alzahrani

Electronic Theses and Dissertations

A lack of social communication skills, including initiation and responding, has been a prominent characteristic of children diagnosed with ASD (Kanner, 1943; Kroeger et al., 2007). Enhancing these skills in children with ASD during early childhood is crucial to their future relationships, friendships, participation in communal activities, and overall lowering the likelihood of adverse long-term effects, giving significance to this age as a pivotal period for enhancing various skills (Hart Barnett, 2018). Failure to provide interventions to address social communication in children with ASD, specifically in cultures that value this skill, can impede their integration into that society. Thus, this …

Effectiveness Of Picture Exchange Communication System On Functional Communication For Saudi Children With Autism Spectrum Disorder (Asd), Mohammed Albahrani

Electronic Theses and Dissertations

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by restricted interests, repetitive or inflexible behaviors, and challenges with communication and socialization (Flannery & Wisner-Carlson, 2020). Children with expressive communication disorders, including those with ASD, can benefit from using Augmentative and Alternative Communication (AAC) as a tool to improve their communication skills (Chazin et al., 2016). The AAC approach helps them learn and communicate more effectively by addressing various needs, such as making requests, commenting, or responding to questions (Mirenda, 2001). Many families, special education classrooms, and inclusive settings have adopted the Picture Exchange Communication System (PECS), an evidence-based …

Counselor Perspectives On Substance Use Treatment In Pennsylvania As Medical Cannabis Laws Evolve, Renee L. Ludwig

Electronic Theses and Dissertations

Cannabis, once primarily regarded as a recreational or “party” drug, has undergone a significant shift in public and medical perception over the past two decades. It is now increasingly recognized as a therapeutic agent prescribed within clinical settings. While substantial research has examined the general use of medical cannabis, relatively little attention has been given to its implications for substance use counselors treating clients who use medical cannabis during treatment for substance use disorders. The purpose of this study is to explore the perceptions of substance use counselors regarding client use of medical cannabis and to investigate how such use …

A Fish & A Bird, Deanna Moorehead

Theses

As a curtain of trees opens and dawn breaks over the glistening waters of Lake Ontario, a fish and a bird spot each other through the surface and fall madly in love. They dance and sing together from their respective atmospheres, yet each time the bird soars past the water's edge and onto the beach, the fish cannot follow. Night after night, by the light of the moon, the fish trains herself to leap out of the water, hoping to breach high enough to join her beau above. Late one afternoon, the fish approaches the shore, where the bird stands …

Assessment Of Polymeric Chloroquine Formulations For Targeted Therapy Of Ulcerative Colitis And Metastatic Colorectal Cancer, Neha Kumari

Theses & Dissertations

Effective targeted drug delivery is a critical unmet need in the management of both ulcerative colitis and metastatic colorectal cancer, where conventional systemic therapies may be hindered by suboptimal efficacy and significant side effects. This thesis explores the development and preclinical assessment of polymeric chloroquine (PCQ)-based nanotherapeutics, leveraging stimuli-responsive designs for disease-specific delivery and action.

For ulcerative colitis, a reactive oxygen species (ROS)-responsive nanogel system was engineered to release PCQ, a macromolecular derivative of hydroxychloroquine, specifically in the inflamed areas within the colon. Nanogels with well-defined size and positive surface charge were synthesized via reversible fragmentation chain transfer (RAFT) polymerization …

Role Of Nadph Oxidase 4 In Murine Cancer-Associated Fibroblast, Faith M. Gomez

Theses & Dissertations

Breast cancer is the second leading cause of cancer deaths in women in the United States. Frontline hormone therapies for breast cancer prove ineffective in triple negative breast cancer tumors wherein the hormones estrogen, progesterone, and HER2 are downregulated or absent; therefore, patients diagnosed with triple negative breast cancer are primarily limited to chemotherapies which carry a higher failure and resistance rate. Here we target cancer associated fibroblasts as potential drivers of chemoresistance in triple negative breast cancer. We investigated the mechanism by which Nox4 regulates the YAP/TAZ pathway in modulating DTX sensitivity and sought to determine if targeting Nox4 …

Regulation Of Chromatin Remodeling By The Post-Hsa Domain Of Brg1, A Subunit The Baf Atp-Dependent Chromatin Remodeling Complex, Min Sze Ewe

Theses & Dissertations

The ATP-dependent chromatin remodeler BAF complex regulates nucleosome positioning, chromatin accessibility, and tissue specific gene expression. Its catalytic subunit, BRG1, contains several regulatory domains including the post-HSA region, proposed to modulate ATPase activity. Multiple cancer-associated mutations map to these regulatory regions underscoring their importance, yet the precise role of the post-HSA region in chromatin remodeling remains poorly understood.

To investigate the function of the post-HSA domain, we ectopically expressed FLAG-tagged BRG1 with post-HSA deletion (Δpost-HSA BRG1) in mouse embryonic stem cells. Western blot analysis confirmed expression of the mutant protein. To determine the effects of mutant protein expression on chromatin …

Macroinvertebrate Community Dynamics In A Recovering, Hypersaline Estuary, Catherine M. Eckert, Claudia A. Tamez, Erin E. Easton, David Hicks

School of Earth, Environmental, & Marine Sciences Faculty Publications

The Bahia Grande is a 6,500—acre tidal basin located at the southernmost tip of Texas. Tidal flow into this coastal estuary was cut off in the 1930s, causing the basin to dry up for ~70 y. A pilot channel connecting the Bahia Grande to tidal waters was constructed in 2005, allowing flooding of the basin to occur. Throughout the period reported herein (2005–2019), the system remained characterized by persistent spatial and temporal episodes of extreme hypersalinity (>70)—a critical factor influencing estuarine community composition and driving key ecological processes. With additional rehabilitation actions forthcoming, characterization of the estuary is essential …

Perron Theorem Application To A Second-Order Differential Equation With Small Advances, Jason Hendrix

Theses and Dissertations

We analyze a delayed second order differential equation with small delay parameters, proving spectral stability via the characteristic quasi-polynomial and establishing uniform bounds on derivatives of the Green’s function to ensure sign preservation under perturbation, providing a foundation for monotone iteration methods. These results aim to advance the functional-analytic framework for traveling wave solutions in delayed reaction-diffusion systems.

‘If You Can Dream It, You Can Do It:’ Bridging Creative Ideas & Beliefs In A Neurodiverse Workforce Through Autonomy & Social Support, Mesaley A. Alemseged

Industrial-Organizational Psychology Dissertations

Reports from the business world highlight the competitive advantage that neurodiversity can provide for workplace creativity and innovation through the inclusion of workers who represent a broad range of perspectives and abilities. However, while neurodivergent individuals have naturally divergent ways of thinking, producing creative works might not come as easily in workplaces designed for neurotypical forms of thinking and working. Drawing from the componential theory of creativity, this study sought to explore how neurodivergence, as it relates to creativity-relevant processes, and work characteristics related to the social environment can influence creativity across the various stages of the creative process. While …

Accepting Vs Understanding, Transgender Aliens And Alienation, Reyna G. Aliah

English

Trans people have been the subject of intense discrimination in recent years, suffering dehumanization from right-wing and conservative groups. This dehumanization (and the fear resulting from it) parallels common attitudes in science fiction about actual aliens. Orson Scott Card’s Hierarchy of Foreignness classifies individuals and species into five categories, depending on their sentience; whether they are from the same city, nation, or planet; and whether communication is possible. This paper examines how transgender people can be classified according to this system on a societal level, with said class depending on the lens used to view them as well as the …

Playing By Feel: Gender, Emotion, And Social Norms In Overwatch Role Choice, Cristo Leon, Angela Arroyo, James Lipuma

STEM for Success Resources

This paper explores how emotion, gameplay context, and social norms shape role choice in both digital and institutional systems. Using Overwatch as a case study, it examines gendered experiences of physiological excitement and decision-making during play. Women often describe heightened emotional engagement where victory represents both personal achievement and resistance to cultural expectations. Such emotions influence situational choices, including whether to play as a Tank, DPS, or Support, and which hero to select based on perceived risk or visibility. Drawing on feminist game studies and transdisciplinary communication, the authors argue that role preference is determined not only by game mechanics …

Exploring The Medicinal Properties Of Indigenous Plants Within An Enabling Program: Bridging The Gap Between School, Aboriginal And Torres Strait Islander Knowledge And Science, Sharon L. Gough, Julie Sartori, Angela Jones

Research outputs 2022 to 2026

In 2021, less than half of Australian universities considered Indigenous perspectives in curriculum development, with only 15% ensuring Indigenous content in all courses. Literature acknowledges that a strengths-based approach to the inclusion of Aboriginal and Torres Strait Islander knowledge and perspectives, enhances representation and decolonises curriculum. In 2020, Noongar elder Vivienne Hansen, and John Horsfall created Noongar Bush Medicine, detailing the medicinal use of Indigenous plants. Yeshi, Turpin, Jamtsho, and Wangchuk noted that many Aboriginal and Torres Strait Islander communities use native plants for health purposes. However, there is limited data on the therapeutic efficacy of these plants. In 2024, …

Leveraging Transcranial Ultrasound Stimulation To Enhance Self-Regulation In Emotion And Sleep, Suraya Dunsford, Mica Komarnyckyj, Elsa Fouragnan

School of Psychology

This Perspective article discusses the emerging potential of transcranial ultrasound stimulation (TUS) as a non-invasive neuromodulatory technique for enhancing self-regulatory processes, particularly emotion and sleep regulation, in healthy individuals. Offering high spatial precision and the ability to target both cortical and deep brain regions, TUS uses focused ultrasound waves to induce acute and delayed effects on brain activity. We propose that combining TUS with neurofeedback methods and/or specific cognitive training exercises may capitalise on these neuroplastic effects, thereby augmenting and prolonging their impact to support lasting improvements in self-regulation. We focus on the domains of sleep and emotion regulation, where …

Living Experiences Of Indigenous Health Practice: Belizean Maya Communities And Belize Migrants, Kristina Baines

Maya America: Journal of Essays, Commentary, and Analysis

Belize Maya communities, like many indigenous communities around the world, have long experienced challenges to maintaining health as they interface with an ever-expanding globalized model of development. This essay explores the relationship between traditional ecological practices and health in the context of a holistic understanding of what makes healthy bodies, healthy communities and healthy lives. Using the author’s Embodied Ecological Heritage (EEH) framework and a phenomenological lens, the essay shares how sensory experiences become embodied through everyday practice, promoting health and general wellbeing. This grounded theory, developed in and with Maya communities, helps us understand ways to consider and support …

Evaluation And Calibration Of Coupled Low-Cost Particulate Matter Sensors, Tyler Cargill

McKelvey School of Engineering Graduate Student Theses & Dissertations

Low-cost sensors (LCS), if used appropriately, are useful instruments to elucidate human exposure to particles suspended in the air (i.e. particulate matter, PM). Characterizing this exposure is crucial, as exposure to PM2.5 (i.e. particles with aerodynamic diameter ≤ 2.5 μm) negatively affects the respiratory, cardiovascular, and other organ systems and is the leading environmental burden for global mortality. Similarly, exposure to particles with aerodynamic diameters greater than 2.5 μm and less than or equal to 10 μm, here forth termed as PMCoarse, is known to cause health ailments for the upper respiratory system. This dissertation focuses on the MODULAIRTM-PM (MOD-PM), …

Investigating Metabolic Heterogeneity In Engineered Isogenic Microorganisms, Xinyue Mu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Engineered microorganisms play an increasingly important role in the sustainable production of fuels, bioplastics, and other valuable biomaterials. Successful industrial deployment depends on maximizing product titers and ensuring process robustness at large scale. However, one of the major obstacles is non-genetic cell-to-cell heterogeneity arising from stochastic intracellular processes. Such heterogeneity can result in subpopulations that divert substrates toward growth rather than product biosynthesis, ultimately reducing yield and contributing to batch-to-batch inconsistency. To better understand the mechanisms by which cell-to-cell variation emerges, propagates, and impacts bioproduction, this dissertation investigated how intracellular energetic dynamics and stochastic biosynthetic noise contributed to metabolic heterogeneity …

Transforming Co2 Into Value-Added Products: Liquefied Petroleum Gas And Solid Carbon Materials, Kaiying Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

The escalating climate crisis, driven by anthropogenic carbon dioxide (CO2) emissions, necessitates the development of advanced Carbon Capture and Utilization (CCU) technologies. A critical distinction within CCU lies between transient carbon cycling, which converts CO2 into fuels, and permanent sequestration, which transforms it into durable, solid materials. This dissertation addresses fundamental catalytic challenges across both pathways to develop economically viable and technologically sound solutions for CO2 valorization. This work seeks to answer two primary research questions: (1) How can the catalyst temperature mismatch and stability limitations in the tandem conversion of CO2 to Liquefied Petroleum Gas (LPG) be overcome to …

Beyond Precision: Ambiomic Survivorship In Childhood And Aya Cancer., Juan Antonio Ortega-García, Omar Shakeel, Nicole Wood, Antonio Pérez-Martínez, Jose Luís Fuster-Soler, Mark D. Miller

Manuscripts, Articles, Book Chapters and Other Papers

Background: Survival among children and adolescents and young adults (AYA) with cancer has improved substantially over recent decades; however, dominant survivorship models remain reactive-activated post-treatment and anchored to static exposure- and organ-based screening. This design underuses the anticipatory window at diagnosis and overlooks environmental and social determinants that modulate outcomes across the life course. Methods: We narratively reviewed international frameworks including the Children's Oncology Group (COG), the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG), the Pan-European Network for Care of Survivors after Childhood and Adolescent Cancer (PanCare) and the National Comprehensive Cancer Network (NCCN), and synthesized evidence …

How Design Law Is Taking Shape In The United States And European Union, Christine Haight Farley

Scholarly Articles in Law Reviews & Journals

This Essay uses a comparative framework to show that sophisticated design rights holders in both the United States (U.S.) and the European Union (EU) increasingly sidestep specialized design regimes in favor of more expansive trademark and copyright doctrines. Although both jurisdictions now operate cumulative intellectual property (IP) systems for industrial design, they have taken sharply divergent paths in confronting the proliferation of “design dupes”—replicas that trade on the appeal of sought-after designs. In the United States, rights holders rely chiefly on trademark law, and especially trade dress, to convert cultural recognition into legally cognizable source indication, a move facilitated by …

P-15 Peptide Enhanced Bone Graft Improves Time To Fusion In Transforaminal Lumbar Interbody Fusion: A Randomized, Controlled, Investigational Device Exemption Study, James S. Harrop, Michael P. Steinmetz, John E. O'Toole, Christopher D Chaput, Rick C. Sasso, K. Brandon Strenge, Greg Maislin, Jeffrey P. Mullin, Thomas B. Freeman, Anthony Guanciale, Howard Lantner, Michael E. Janssen, David G. Schwartz, John M. Small, Wellington K. Hsu, Paul M. Arnold

Department of Neurosurgery Faculty Papers

STUDY DESIGN: Prospective, multicenter, single-blind, randomized, and controlled pivotal study.

OBJECTIVE: Compare time-to-fusion in patients treated with P-15L (PearlMatrix TM P-15 peptide enhanced bone graft) versus local autograft over 24 months and evaluate changes in pain and quality of life at 24 months relative to baseline.

SUMMARY OF BACKGROUND DATA: P-15L, an FDA-designated breakthrough device, is a composite bone graft with P-15, a 15-amino acid polypeptide that promotes cellular adhesion, proliferation, and differentiation to support bone formation.

METHODS: Patients (22-80 y) with degenerative disc disease were randomized to the investigational (P-15L) or control (local autograft) group during single-level transforaminal lumbar …

Late-Stage Capitalism And Consumerism In Higher Education: A Morphogenetic Analysis, Kallen Zhou

Publications

Facing widespread student disengagement and dissatisfaction, U.S. higher education is undergoing a paradigm shift, detaching from its civic and pedagogical origins. A key force driving this transformation is the rise of student consumerism. While existing literature documents market-driven actions adopted by higher education institutions (HEIs) and the consumer roles students play, it overlooks structural market forces. Specifically, little theorization exists on the relationship between late-stage capitalism and student consumerism. This paper addresses that gap through two steps: first, offering a historical analysis of the traditional university model, late-stage capitalism, academic capitalism, and the decline of the liberal arts; second, developing …

Creating A Radical Social Change Campaign To Restore Rational Thinking: A Theoretical Framework, John S. Long

Student Theses and Dissertations

Rational thinking is a skill and mindset that is under siege in modern society, becoming increasingly endangered as we devolve into increasingly hyper-partisan communities rife with echo chambers and confirmation biases. The most basic processes of analyzing issues and facts to develop clearly thought-out and defendable positions have been abandoned in favor of a zealous devotion to toe the party line, no matter the evidence or implications. What we are witnessing firsthand is the fast-approaching culmination of the post-truth era.

One might assume that an issue with such far-reaching implications across our entire society would generate a significant amount of …

Data Storytelling For Reputation Management: A Multiple Case Study Of Formula 1, Patagonia & Spotify, Michael O. P. Lowsley-Williams

Student Theses and Dissertations

This thesis investigates data storytelling as a reputation management strategy by examining how organizations leverage data narratives to enhance brand identity, build stakeholder trust, and reshape public perception. Through analysis and comparison of three qualitative case studies of Patagonia, Formula 1, and Spotify, this research explores how these companies construct and utilize data-driven narratives to address reputational challenges across distinct industry contexts. Drawing on elements of framing, situational crisis and stakeholder theories as well as the concepts of encoding and decoding, this study analyzes narrative structures, framing devices, and audience engagement tactics within reports, campaigns, and multimedia content from 2015-2025. …

Gowanus Faces A Hidden Threat Beneath Its Neighborhood Boom, Emma J. Rosenberg

Capstones

This article investigates urban redevelopment, climate change and environmental contamination in Brooklyn’s Gowanus neighborhood. The Gowanus Canal itself has been a designated EPA Federal Superfund Site since 2010, this designation does not apply to the land surrounding it where legacy industrial contamination still exists. This includes coal tar from former manufactured gas plants which poses a risk to groundwater and indoor air. Under a 2021 rezoning plan, large-scale residential redevelopment is rapidly moving forward, rising groundwater and increased flooding associated with climate change may exacerbate contaminants. Utilizing agency documents, Community Advisory Group meetings, and conversations with residents, advocates, officials and …

Flooding, Not Just A Rain Problem, Annisha Singh

Capstones

This capstone focuses on the Rockaway Peninsula and how high-tide flooding also known as "sunny-day flooding" is not only affecting Rockaway but neighboring areas, such as Jamaica Bay.

Amidst The Struggles, Nyc Actors Say The Pursuit Of Their Craft Is Always Worth It, Allison Dubrow

Capstones

Despite high ticket prices and safety concerns, Broadway has had a record-breaking season, surpassing pre-pandemic box office revenue largely due to star-driven productions. While the industry is financially thriving, many NYC actors struggle to make a livable wage and rely on non-acting jobs to support themselves. The uncertainty of auditions and booking work makes sustaining an acting career especially difficult in such a competitive city. This project highlights the contrast between Broadway’s success and the resilience it takes for actors to survive and pursue their craft in New York City.

Relief, At A Cost: New Bill Forces Landlords To Offer Ac, But Leaves Tenants With The Bill, Niamh Mcauliffe

Capstones

As summers in New York City are getting hotter and hotter every year due to climate change, lack of home air conditioning is a serious issue. A newly passed City Council bill would require landlords to provide air conditioning upon tenant request. While advocates see the legislation as a necessary step to protect tenants from the dangers of extreme heat, there are still unresolved questions around energy affordability, costs and implementation.

https://docs.google.com/document/d/1XgVilwyn6ncwVbslr1UcdP6p-3OwGQAseHXMY3EYCeY/edit?usp=sharing