Digital Commons Network^™

Novel Chiral Interstellar Molecules: Quantum Anharmonic Ir And Vcd Predictions, Meredith Paik

Dissertations, Master's Theses and Master's Reports

The 2016 discovery of the chiral molecule propylene oxide (C₃H₆O) in the interstellar medium (ISM) has opened new avenues into explaining the origin of biomolecular homochirality on Earth. Thus, studies of chiral molecules in the ISM may be able to reveal more about the mechanism behind homochirality. However, while the search for chiral molecules in space has become an active field of study, astrochemical researchers have yet to detect other chiral molecules in the ISM. For this purpose, numerous characteristics for detectability have been outlined that may facilitate the discovery of other interstellar chiral molecules. With …

Applied Forest Restoration And Conservation In Michigan: Advancing American Beech Restoration And Documenting A Historical Insect Collection, Thomas E. Panella

Dissertations, Master's Theses and Master's Reports

Forest restoration and conservation require both practical management approaches and the preservation of biological resources that support future research. This dissertation presents applied research conducted in Michigan that advances American beech (Fagus grandifolia) restoration in response to beech bark disease (BBD) while documenting an important historical entomological resource. Chapters 1–3 focus on overcoming practical barriers to American beech restoration. Restoration protocols were developed and refined for identifying BBD-resistant trees, graft propagation, rootstock collection, container production, and the field establishment of grafted BBD-resistant trees. A greenhouse experiment evaluated the influence of growing media and fertilization on container stock quality, …

Targeted And Screening Based Approaches To Analyze Drm Transcriptional Repressor Complex Activity In Caenorhabditis Elegans, Emily Washeleski

Dissertations, Master's Theses and Master's Reports

The molecular machinery that control the eukaryotic cell cycle, specifically the processes that mediate the switch between cellular division or quiescence, are essential for cellular and organismal viability. However, how the same machinery integrates with developmental or differentiation programs is less well understood. In Caenorhabditis elegans, the 8-subunit DRM complex (for Dp, Rb and MuvB), whose subunits belong to the Synthetic Mulitivulva (SynMuv) B class genes, is a central regulator of the cell cycle but also prevents inappropriate cell fate specification. The conserved mammalian DREAM complex (for Dp, Rb, E2F, And MuvB) is best known as a transcriptional repressor …

First-Principles Investigation Of Quasi-One-Dimensional Van Der Waals Magnets For Advancing Low-Dimensional Spintronics, Alyssa Horne

Dissertations, Master's Theses and Master's Reports

Van der Waals (vdW) magnets have been of great interest for advancing low- dimensional spintronics. A notable example is the quasi-one-dimensional (Q1D) vdW CrSbSe₃, as it is composed of individual one-dimensional units that are held together by the vdW forces. Finding other Q1D vdW magnets that exhibit non-metallic behavior together with long range ferromagnetic ordering is critical in developing next generation spintronics. Here in, using first-principles density functional theory (DFT), we investigate the compositional effects on electronic and magnetic behavior of Cr_1–xMn_xSbSe₃ (x = 0, 0.5, 1). When 50% of Cr is replaced …

Using Automotive Lidar To Reduce The Energy Consumption Of An Ego Autonomous Vehicle, Logan P. Schexnaydre

Dissertations, Master's Theses and Master's Reports

There is significant potential to reduce the energy consumption of the transportation sector through autonomous vehicles. Prior work on autonomous vehicle energy efficiency focuses on the whole system or the control subsystem. Yet, the sensing and processing components, which have direct and indirect effects on net energy use, are less explored. This dissertation fills this gap by modeling and evaluating these effects for lidar sensors, which provide high-resolution spatial data at the cost of high power and processing demands. I apply lidar to the energy-saving tasks of automated vehicle following and road surface profiling. For automated vehicle following, I model …

Analytical And Data-Driven Modeling And Control Of Nonlinear Point Absorber Wave Energy Converters With Application To Cone–Cone Buoy Geometries, Houssein Yassin

Dissertations, Master's Theses and Master's Reports

This dissertation develops analytical modeling, numerical simulation, experimental validation, and data driven control methods for nonlinear point absorber wave energy converters, with particular emphasis on cone--cone buoy geometries. Geometry dependent nonlinear force models are first derived using pressure field and displaced volume formulations. These models show how buoy geometry produces nonlinear Froude--Krylov and restoring forces, including the dominant cubic behavior of cone--cone geometries.

The derived models are incorporated into a feedback linearization framework that compensates selected nonlinear dynamics while retaining the incident wave terms. An analytical optimal control formulation is also developed to maximize harvested energy in nonlinear, nonautonomous systems …

Rapid Austenite Restoration Through Non-Partitioning Transformation In Medium-Mn Steel, Rebekah A. Smith

Dissertations, Master's Theses and Master's Reports

Steel microstructures that contain retained austenite exhibit unique mechanical flow behavior which renders them applicable to high-strength forming, and energy absorbing applications. Austenite stability is predominantly controlled through substitutional alloy enrichment, and during deformation, meta-stable austenite transforms to martensite which induces dramatic work hardening that may enhance mechanical properties. After deformation, these steels have greater yield strength but limited remaining ductility. Restoration of austenite through rapid thermal treatments, after it is expended through deformation, can enable retained austenite to be leveraged for additional deformation. In the present work, a rapid austenite restoration heat treatment following deformation-induced martensite transformation is presented …

Enhancing Coastal Vulnerability Assessments And Policy Impacts On Socioeconomic And Environmental Equity In Michigan's Great Lakes Communities, Esther N. Acheampong

Dissertations, Master's Theses and Master's Reports

Accelerating shoreline erosion, fluctuating lake levels, and climate-induced hazards are transforming the Great Lakes’ freshwater coasts, exposing the limitations of static and inequitable management frameworks. This dissertation investigates how Michigan’s coastal governance systems produce and manage vulnerability along the Lake Michigan shoreline by integrating geospatial modeling, institutional policy analysis, and environmental justice theory. It argues that both physical processes and institutional designs co-determine patterns of exposure, protection, and equity. The research begins by developing a refined Coastal Vulnerability Index (CVI) tailored for lacustrine environments, applying it to Muskegon County to assess how shoreline change, armoring, and seasonality influence localized risk. …

Multi-Level Energy Optimization For Connected And Automated Vehicles: From Cooperative Multi-Vehicle Control To Individual Powertrain Management, Pruthwiraj Santhosh

Dissertations, Master's Theses and Master's Reports

The transportation sector currently accounts for nearly 30% of global energy consumption, necessitating urgent advancements in vehicle efficiency to meet Net Zero targets. Leveraging connectivity and automation, this dissertation proposes and validates methodologies to reduce the energy consumption of light-duty vehicles at both fleet and individual levels.

First, a validation framework is developed to bridge the “simulation-to-real world” gap in Cooperative Automated Vehicle (CAV) research. Moving beyond virtual simulations, the study establishes a methodology for physically validating centralized control architectures via a custom Cellular V2X network. By synchronizing vehicle-powertrain models with physical test vehicles, the framework successfully orchestrates complex arterial …

Design, Syntheses And Biological Applications Of Fluorescent Probes For Nad(P)H, Hsa And Cellular Microenvironment Sensing, Adenike M. Olowolagba

Dissertations, Master's Theses and Master's Reports

Fluorescent probes have emerged as powerful tools for investigating complex biological processes due to their high sensitivity, selectivity, and capability for real-time, non-invasive imaging. In particular, the detection of key biomolecules such as NAD(P)H, viscosity-related parameters, human serum albumin (HSA), and pH is essential for understanding cellular metabolism, redox homeostasis, and disease progression. In Chapter 2, three coumarin-based fluorescent probes (A–C) were designed, synthesized, and characterized for monitoring NAD(P)H levels in living cells. Probes A and B feature coumarin–cyanine hybrid structures linked via vinyl and thiophene bridges to 3-quinolinium acceptors, respectively, while probe C incorporates a dicyano moiety to replace …

Modular Synthesis Of Conjugated Aromatic Systems Via Palladium-Catalyzed Cross-Coupling Reactions, Joden Russell Robinson

Dissertations, Master's Theses and Master's Reports

This thesis describes the development of a modular synthetic route to extended conjugated aromatic systems through iterative palladium-catalyzed Sonogashira crosscoupling reactions. The work was motivated by the challenge of preparing a discrete conjugated molecule in a controlled manner. The synthetic strategy used complementary protected alkyne functionalities that could be selectively activated. This enabled sequential deprotection and coupling reactions to predictably extend the molecular scaffold. Using this approach, a series of conjugated intermediates was prepared and exponentially extended. Spectroscopic characterization by NMR and mass spectrometry supported the structures of the isolated products and the success of the iterative elongation strategy. Overall, …

Minimizing Snow Loss On Fixed Tilt Solar Pv Installations Through Frame Material Selection And Installation Layout, David B. Wallis

Dissertations, Master's Theses and Master's Reports

This thesis investigates the effects of frame material selection, module orientation and module gaps on photovoltaic energy production in a snowy environment. These factors are easily implemented in new PV installations at minimal or no extra cost. These experiments are installed as fixed tilt arrays at 35° with DC current, DC voltage, and meteorological monitoring. The frame material and module gap experiments both produced actionable results. In the frame material experiment, consistent event level energy production gains resulted in seasonal production gains favoring aluminum framed modules. In the module gap experiment energy gains are independent of atmospheric conditions. The orientation …

Aqueous Iron Electrowinning: From Electrolyte Engineering To The Unexplored Potential Of Acetate Systems, Chodwell N. Verenga

Dissertations, Master's Theses and Master's Reports

Iron electrowinning and electrodeposition sit at the intersection of classical metallurgy and developing sustainable manufacturing. With the iron and steel industry responsible for 7 - 9% of global CO₂ emissions, low-temperature electrochemical pathways for iron production have garnered significant research interest. This review examines the fundamental electrochemical principles governing iron deposition, the thermodynamic constraints imposed by the iron-water system, and the kinetic challenges posed by the parasitic hydrogen evolution reaction (HER). The three key electrolyte systems are objectively evaluated: acidic sulfate and chloride electrolytes, alkaline suspension electrolytes and water-in-salt electrolytes. Their operating parameters, faradaic efficiencies, energy consumption and deposit characteristics …

First-Principles And Thermodynamic Modeling Of Hydrogen Storage In Mxenes, Yi Zhi Chu

Dissertations, Master's Theses and Master's Reports

Hydrogen storage is a critical component of the emerging hydrogen economy, playing a central role in enabling the global transition from fossil fuels to a sustainable, green energy system. With advances in materials research, increasing attention has been directed toward the development of promising hydrogen storage materials. Due to their diverse and advantageous physicochemical properties, MXenes have attracted significant interest in this regard. A fundamental understanding of the hydrogen interactions with the MXenes structure is crucial for explaining and predicting their hydrogen storage performance. In this work, first-principles density functional theory (DFT) combined with a revised thermodynamic model is employed …

Designing With Foresight: Premortem And Human-Centered Evaluation Of Emerging Technologies, Anusha Kannan

Dissertations, Master's Theses and Master's Reports

Artificial intelligence is increasingly embedded in safety-critical systems, including transportation, where people must make fast decisions under uncertainty and high risk. As AI takes on a larger role in supporting human judgment, researchers and designers must evaluate more than just its technical performance, they must ask whether people can understand the system and use it effectively in high-risk settings.

This dissertation presents two distinct evaluation methodologies. First, the Human-Centered Evaluation, examines how intelligent in-vehicle alert systems influence driver decision behavior across two experiments. In Experiment 1 (n=24) and Experiment 2 (n=26), participants completed a driving simulator study in which our …

An Investigation On Downwind Impacts Of The Keweenaw Peninsula On Lake-Effect Snow Events, Thomas M. Pavell

Dissertations, Master's Theses and Master's Reports

Lake-effect snow (LES) produces copious amounts of snow across the Great Lakes region. While mechanisms and impacts are well-understood, they remain difficult to observe and study over Lake Superior and the Upper Peninsula of Michigan due to a large gap in radar coverage and sparse in-situ measurements. The goal of this project aimed to characterize variables present across Lake Superior and counties on and downstream of the Keweenaw Peninsula that contribute to the formation and evolution of lake-effect snowbands. Nine different lake-effect snow events were analyzed in this project, identifying structures and features resulting from upstream passage over the Keweenaw …

Correlation Of Mwd Parameters And Soil Properties In Nebraska With Geospatial Visualization Of Borehole Data, Michael N. Erzuah

Dissertations, Master's Theses and Master's Reports

One of the techniques used for recording a drilling system in terms of its mechanical response is Measurement While Drilling (MWD). A combination of recorded MWD parameters can be used to form compound parameters by utilizing different physics-based equations. Several engineering and index properties of the subsurface material can be correlated using these combined parameters for site characterization. In this study, we investigated the outcome of correlations between different compound parameters and SPT-N values using MWD data from four different boreholes in the state of Nebraska, USA drilled using tricone bits and mud rotary method. An interactive web map was …

Exploring New Poly-Anion Based Materials For Lithium – Ion Battery Cathodes, Sutapa Bhattacharya

Doctoral Dissertations

The escalating global demand for sustainable energy storage solutions has driven intensive research into novel electrode materials. Polyanion-based cathode materials have emerged as promising candidates due to their structural stability, safety, and voltage tunability enabled by the inductive effect of polyanionic groups. This research explores the synthesis, crystal structure, and electrochemical performance of new polyanion-based cathode materials featuring vanadium, molybdenum, and iron within phosphate and selenite frameworks.

Novel selenite-based materials, such as LiFe(SeO₃)₂ and Li₀.₂₅V₂O₃(SeO₃)₂, were synthesized and characterized, revealing stable electrochemical cycling associated with Fe2+/Fe3+ and V⁴⁺/V⁵⁺ transitions. Additionally, a systematic investigation was conducted on molybdenum phosphate compounds, including …

Adaptive Machine Learning Framework For Microstructural Optimization And Mechanical Performance Prediction In Steels, Henry Adekola Haffner

Doctoral Dissertations

Evolution of microstructures, such as polygonal ferrite, acicular ferrite, bainite, and martensite, plays a pivotal role in determining the final microstructural and mechanical properties of steel products. Given the established inter-relationship between processing parameters, microstructure, properties, and performance, precise control of phase transformation is essential to achieve pre-determined properties. To understand transformation routes in different steel grades, time-temperature-transformation (TTT) and continuous-cooling-transformation (CCT) diagrams are necessary and can be described using the Johnson-Mehl-Avrami-Kolmogorov equation and Scheil’s additivity rule. This study presents a comprehensive computational framework for predicting and optimizing microstructure and mechanical properties in advanced high-strength steels (AHSS) using adaptive machine …

Advancing Coal Rib Support Design Through The Integration Of Field Studies And Numerical Simulations, Alper Kirmaci

Doctoral Dissertations

Coal rib stability remains a major safety concern in U.S. underground coal mines, with rib failure-related injuries and fatalities still occurring. A key challenge is the lack of a standardized methodology for designing rib support systems that can address varying geological conditions. As a result, many mines rely on trial-and-error or traditional practices, leading to inconsistent designs. This research aims to develop a systematic methodology for rib support design to improve coal rib stability in U.S. mining operations.

The study consists of: i) field monitoring in active room-and-pillar coal mines, ii) in-situ pull-out tests on coal ribs, iii) numerical model …

Fully Differential Studies On Dissociative Capture In P + D2 Collisions And On Ionization In P + He Collisions, Shruti Majumdar

Doctoral Dissertations

Advancing our understanding of few-body dynamics in simple atomic systems is a fundamental objective in atomic scattering research. The underlying problem is that the Schrödinger equation is not analytically solvable for more than two mutually interacting particles. This involves a comprehensive exploration of various channels, such as ionization, capture, and excitation. A common theoretical approach to describe ion-atom collisions is based on perturbation theory, where the scattering amplitude is expanded in powers of the interaction potential. Here, understanding the few-body problem means accurately describing the relative importance of the higher- vs the first order terms.

In the case of ionization, …

Accelerating Circular Economy Transition For A Sustainable Built Environment: A Systems-Based Framework, Radwa Walid Yassin Eissa

Doctoral Dissertations

"The Circular Economy (CE) has gained momentum as a transformative framework for steering the construction value chain towards greater sustainability. However, this transition requires shifts in production and consumption patterns, adoption of circular business models, and the replacement of linear practices. Despite growing interest, CE adoption in construction faces persistent challenges, including sectoral fragmentation, lack of integrated governance frameworks, and limited coordination among stakeholders. This dissertation aims to accelerate the CE transition in the built environment through a multi-scale, interdisciplinary approach spanning five modules: (1) Module 1 develops a construction value chain-structured portfolio of CE strategies and assesses their implementation; …

Bond Graph And Extended Generalized Average Method With Applications In Cyber-Physical Systems And Power Electronics, Arnold Anthony Fernandes

Doctoral Dissertations

"This research examines two applications of control theory. The first application considers the bond graph (BG) modeling technique, which is used to develop the MATLAB structural analysis toolbox (MATSAT), an open-source toolbox for sensor placement and qualitative system analysis that considers the observability and fault-detection capabilities of multi-domain cyberphysical systems. The toolbox provides information on redundant sensors, guiding the system designer in cost and security trade-offs. The toolbox uses traditional BG causality assignment procedures. Additionally, MATSAT provides optimal causality assignment methods that perform significantly better at assigning causality to BGs with increased junctions, sources, and simple meshes, without encountering causality …

Laws Of Mechanics And Stationary Black Holes, Asma Iqbal

Master of Science in Mathematics

The aim of this thesis is to study laws of mechanics of Black Holes in the context of General Relativity. Important tools of General Relativity have been covered including concept of curvature and causal structure of spacetime. It then explore some characteristics of Schwarzschild and Kerr Black Holes and derived global quantities of them. These global quantities which are defined on Event Horizon of Black Hole makes analogy with the thermodynamics of physics. It then presents the Black Hole analogue of the zeroth, first, second and third laws of classical mecanics in General Relativity.

Approximation Of Solution Of Certain Nonlinear Problems With Applications, Faisal Aijaz

Master of Science in Mathematics

In the thesis, we established the strong convergence of inertial iterative scheme designed to approximate the common solutions of the equilibrium and the fixed-point problem for non-expansive mappings in Hilbert spaces. Through extensive numerical analysis, we analyze the efficiency of the algorithm and demonstrate that the incorporation of the inertial technique yields a significantly faster convergence rate than existing comparable schemes. Furthermore, we examine the effect of initial value on the convergence dynamics, offering visual and comparative assessments against classical methods. To highlight the practical utility and versatility of our framework, we apply the algorithm to signal restoration problems, and …

Metric And Dominant Metric Dimension Of Weakly Zero-Divisor Graphs, Adnan Hussain

Master of Science in Mathematics

This thesis investigates the metric dimension and dominant metric dimension of weakly zero-divisor graphs associated with commutative rings. The study focuses on determining resolving sets and dominating resolving sets for several classes of Γ(Z𝑛) graphs. These results establish connections between algebraic properties of rings and combinatorial characteristics of their associated graphs.

Deep Learning And Computer Vision-Based Modeling For A Real-Time Traffic Congestion Monitoring Framework, Neil Dustin Benedict A. Agner, Angelo B. Dela Cruz, Aster Benedict A. Mangabat, Raphael B. Alampay, Patricia Angela R. Abu

Ateneo Laboratory for Intelligent Visual Environments

As intelligent traffic systems evolve to manage complex urban mobility, conventional congestion estimation techniques, such as the time-windowed Volume-to-Capacity (V/C) ratio, fail to capture capture the real-time traffic situation. Because these methods rely on vehicles crossing a specific point, they often fail to register stopped cars, creating a ‘zero flow’ paradox where complete gridlock is incorrectly categorized as an empty, free-flowing road. To address these limitations, this study proposes an end-to-end computer vision framework utilizing the Real-Time DEtection TRansformer (RT-DETR) model to quantify vehicle volume and immediately classify a roadway’s Level of Service (LOS) through spatial density. In processing video …

Modulation Of Ccr2/Ccl2 Molecular Axis In The Expansion And Rupture Of Abdominal Aortic Aneurysms, Ryan Wahidi, Santiago Elizondo-Benedetto, Ryan Catlett, Bera Koklu, Mohamed A Zayed

2020-Current year OA Pubs

The CCR2/CCL2 molecular axis is a critical mediator of abdominal aortic aneurysm (AAA) pathogenesis. It has been demonstrated to drive chronic inflammation, extracellular matrix degradation, and vascular remodeling through the recruitment and activation of monocytes/macrophages and other immune cell types. Pre-clinical studies demonstrate that CCR2 inhibition reduces AAA formation, expansion, and progression in animal models. Emerging imaging techniques have validated CCR2 as a biomarker for AAA instability in humans. Although clinical trials targeting CCR2 are currently limited in number, ongoing translational studies highlight that CCR2 blockade is a promising therapeutic strategy to mitigate AAA expansion and the risk of rupture. …

Eligibility For Anti-Amyloid Treatment In A Multiethnic Community-Based Study, Lydia Trudel, Joseph Therriault, Arthur C Macedo, Karin L Meeker, Meredith N Braskie, Arthur W Toga, Serge Gauthier, Paolo Vitali, Suzanne E Schindler, Sid E O'Bryant, Pedro Rosa-Neto

2020-Current year OA Pubs

INTRODUCTION: The approval of anti-amyloid monoclonal antibodies (mAbs), including lecanemab and donanemab, represents a significant advance in disease-modifying therapies (DMTs) for early Alzheimer's disease (AD). While appropriate use recommendations (AURs) have been established to guide clinical decision-making, the proportion of individuals with cognitive impairment in real-world, multiethnic populations meeting eligibility criteria remains unknown, as do potential differences in treatment-related risks across ethnic groups.

METHODS: We included 513 cognitively impaired individuals from the Health and Aging Brain Study-Health Disparities study, a multiethnic community-based cohort. Eligibility for lecanemab and donanemab was determined using published AUR criteria. Counts of amyloid-related imaging abnormalities were …

Ex Vivo Assessment Of Keratinocytic Carcinomas Using A Fast Mid-Infrared Probe., Maria G Vazquez De Vasquez, Rebecca C Bradley, Charles L Hitchcock, Angela S Casey, Austin Cusick, James V Coe, Ronald Siegle

Ambulatory and Primary Care Articles

A fast mid-infrared spectral probe was used to record infrared (IR) spectra of fresh skin tissue removed from patients with biopsy-proven keratinocytic cancer (KC) during Mohs surgery. A 150-patient library of IR spectral data was obtained to see if KC on the epidermal side (outside) of tissue samples can be differentiated from adjacent nonmalignant tissue and normal skin. A linear support vector machine model minimized overtraining predicting the contributions to decisions at each step in the spectrum. Training with an equal cost for KC and nontumor cases samples demonstrated a KC sensitivity of 93% ± 5% and specificity 82% ± …