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Evaluation Of The Frequency Of Subclinical Peripheral Neuropathy Among Children And Adolescents With Type 1 Diabetes Mellitus Using Nerve Conduction Studies, Hadeer Ashraf Abdulwahab, Ann A. Abdelkader, Nanees Salem, Bothina Hasaneen Jan 2026

Evaluation Of The Frequency Of Subclinical Peripheral Neuropathy Among Children And Adolescents With Type 1 Diabetes Mellitus Using Nerve Conduction Studies, Hadeer Ashraf Abdulwahab, Ann A. Abdelkader, Nanees Salem, Bothina Hasaneen

Mansoura Medical Journal

Background: The long-term vascular complications of diabetes mellitus (DM) include nephropathy, retinopathy, neuropathy, and macrovascular diseases, so the aim of this study was to evaluate the frequency of subclinical peripheral neuropathy among children and adolescents with Type 1 DM using nerve conduction studies (NCSs) in relation to diabetesrelated clinical and metabolic parameters. Methods: This cross-sectional study was conducted on 50 children and adolescents with T1D. The patients were divided into 2 groups, symptomatic group who had symptoms or signs of diabetic sensorimotor polyneuropathy (DSPN) and asymptomatic group who had no signs or symptoms of polyneuropathy. NCSs were conducted and sensory …


Management Of Seroma After Posterior Lumbar Spine Decompression, Ayman Mohamed Basha, Ahmed Anas Zahra Jan 2026

Management Of Seroma After Posterior Lumbar Spine Decompression, Ayman Mohamed Basha, Ahmed Anas Zahra

Mansoura Medical Journal

Background: Postoperative seroma formation represents a significant complication following posterior lumbar spine decompression (PLSD) that can compress neural structures, cause radiculopathy, and serve as potential infection sources. This study evaluated the clinical characteristics and therapeutic approaches for seroma formation after posterior lumbar decompression procedures.

Methods: An observational study was conducted on 140 patients aged 18 years and older who underwent elective PLSD. Patients were systematically evaluated at predetermined intervals using clinical examination and diagnostic imaging when seroma was suspected. Management protocols were stratified according to seroma size, symptom severity, and clinical progression, ranging from conservative compression dressings to percutaneous aspiration …


Epidemiology Of Closed Ruptured Tendoachilles, Hesham Mousad Alsakaan, Wael Mansour Wafa, Mohieb Sayed Ahmed, Ahmed El Sayed Magdy Elhawary Jan 2026

Epidemiology Of Closed Ruptured Tendoachilles, Hesham Mousad Alsakaan, Wael Mansour Wafa, Mohieb Sayed Ahmed, Ahmed El Sayed Magdy Elhawary

Mansoura Medical Journal

Background: To restore tendon function and avoid long-term impairment, early diagnosis and adequate treatment are crucial. The purpose of this study was to ascertain the incidence pattern of ATR and to pinpoint possible variables related to presentation and management approach.

Aim  identifying potential risk factors either patient or environmental related and to assess the incidence rate of ATR

Patients and Methods: This retrospective cross-sectional study was performed on 87 achilles tendon rupture patients. All the patients were subjected to full medical history taking. Clinical examination was performed including thompson test and Matles test and radiological investigations.

Results: The median age …


Effect Of Adenotonsillectomy On Nocturnal Enuresis In Children With Obstructive Sleeping Apnea, Ramla Dahir Hersi, Hossam El-Sayed Elsisi, Ahmed Abdoo Elzehzahy Jan 2026

Effect Of Adenotonsillectomy On Nocturnal Enuresis In Children With Obstructive Sleeping Apnea, Ramla Dahir Hersi, Hossam El-Sayed Elsisi, Ahmed Abdoo Elzehzahy

Mansoura Medical Journal

Background: Nocturnal enuresis (NE) is the involuntary passage of urine during sleep and is a common condition in the pediatric population. Obstructive sleep apnea (OSA), characterized by recurrent episodes of upper airway obstruction during sleep, has increasingly been identified as a significant contributing factor to NE. Previous studies indicate that children with OSA have a higher prevalence of bedwetting than their healthy counterparts.

Objective: To assess the impact of adenotonsillectomy (AT) on NE in children diagnosed with obstructive sleep apnea.

Methods: This prospective study enrolled 20 pediatric patients presenting with both NE and OSA secondary to severe adenotonsillar hypertrophy. Tonsillar …


Clinico-Epidemiological Profile Of Iron Deficiency Anemia Among Egyptian Primary School Aged Children: A Hospital Based Study, Rabab Fathy Abdelhamid, Noha Essam, Mona Mohamed Taalab Jan 2026

Clinico-Epidemiological Profile Of Iron Deficiency Anemia Among Egyptian Primary School Aged Children: A Hospital Based Study, Rabab Fathy Abdelhamid, Noha Essam, Mona Mohamed Taalab

Mansoura Medical Journal

Background: Iron deficiency anemia (IDA) is the most prevalent cause of anemia among Egyptian children and is associated with a range of hematologic and non-hematologic complications, some of which may be irreversible. This study aims to evaluate the clinical profile and identify factors associated with severe IDA in primary school–aged children.

Methods: This cross-sectional study included 420 primary school–aged children diagnosed with IDA who attended the outpatient clinic of Salamoun El-Qumash Family Medicine Centre. Data were collected through face-to-face interviews using a structured questionnaire. All participants underwent a thorough clinical examination and laboratory evaluation, including a complete blood count and …


The Role Of Adult Appendicitis Score In Reducing The Negative Appendectomy Rate, Mohamed Mahmoud Mansour El Ghzzawy, Magdy Basheer, Mohamed Balata, Amir A. Fikry Jan 2026

The Role Of Adult Appendicitis Score In Reducing The Negative Appendectomy Rate, Mohamed Mahmoud Mansour El Ghzzawy, Magdy Basheer, Mohamed Balata, Amir A. Fikry

Mansoura Medical Journal

Aim: Approximately 15 – 30% of all acute appendectomies are performed based only on clinical suspicion. A negative appendectomy has a 10–12% morbidity rate, which could be detrimental to patients. The current study aimed to evaluate the effectiveness of adult appendicitis score (AAS) in accurate identification of cases with acute appendicitis.

Patients and Methods: This prospective observational study was conducted on 150 patients who presented with manifestations of acute appendicitis admitted to Mansoura Emergency Hospital.  The AAS was calculated, the decision on appendectomy was solely based on the surgeon’s clinical judgment after taking into consideration all the findings of clinical, …


Assessment Of Health-Related Quality Of Life In Pediatric Patients With End Stage Renal Diseases, Nasteho Adan Awil, Ahmed Mahmoud Elrefaey, Abdel-Hady El-Gilany Abdel-Elfattah, Heba Mohamed El-Taher Jan 2026

Assessment Of Health-Related Quality Of Life In Pediatric Patients With End Stage Renal Diseases, Nasteho Adan Awil, Ahmed Mahmoud Elrefaey, Abdel-Hady El-Gilany Abdel-Elfattah, Heba Mohamed El-Taher

Mansoura Medical Journal

Background: End-stage renal disease (ESRD) occurs when the glomerular filtration rate falls below 15 mL/min, requiring renal replacement therapy. Despite improved survival, affected children experience significant physical, emotional, and social challenges. Consequently, health-related quality of life (HRQoL) is markedly reduced compared with healthy peers.

Aim: This study aimed to assess health-related quality of life (HRQOL) in pediatric patients with end-stage renal disease (ESRD) and to identify factors associate with the quality of life in pediatric patients with   end stage renal disease (ESRD).

Methods:  All 60 eligible children who were enrolled in the Nephrology Unit at Mansoura University Children's Hospital …


Diagnostic Performance Of Digital Breast Tomosynthesis In The Characterisation Of Breast Lesions: Correlation With Sono-Mammography And Histopathology., Amira Hamed Megahed, Mona Mahmoud Zaky, Maha Mohamed Bilal Jan 2026

Diagnostic Performance Of Digital Breast Tomosynthesis In The Characterisation Of Breast Lesions: Correlation With Sono-Mammography And Histopathology., Amira Hamed Megahed, Mona Mahmoud Zaky, Maha Mohamed Bilal

Mansoura Medical Journal

Background: Breast lesions range from benign to malignant, with early detection critical for management. Digital mammography is the standard screening tool but may be limited in dense breasts. Ultrasound (US) aids lesion characterisation, while digital breast tomosynthesis (DBT) reduces tissue overlap, enhancing lesion detection.

Objective: To evaluate the diagnostic performance of digital breast tomosynthesis in the characterisation of breast lesions compared with sono-mammography, using histopathology as the reference standard.

Methods: This prospective study included 33 symptomatic female patients with a mean age (45.4 ± 8.2 years) who presented with symptoms such as palpable breast lumps, Mastalgia and nipple discharge between …


Laparoscopic Versus Open Redo Anti-Reflux Surgery, Mohamed Barkok, Mohammed Said, Ahmed Shehta, Abdel-Raouf El-Geidie Jan 2026

Laparoscopic Versus Open Redo Anti-Reflux Surgery, Mohamed Barkok, Mohammed Said, Ahmed Shehta, Abdel-Raouf El-Geidie

Mansoura Medical Journal

Background

Gastroesophageal reflux disease (GERD) is common. Laparoscopic fundoplication became the gold standard for GERD surgery after medical treatment failed. If a previous anti-reflux surgery fails, redo surgery requires a thorough review to determine the cause and a skilled surgical team. Choosing the optimal approach during the redo surgeries, whether open or laparoscopic hasn’t been previously illustrated.

Aim

To compare the outcomes of laparoscopic versus open redo anti-reflux surgeries.

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Patients and methods

This study included 28 patients who underwent redo anti-reflux surgery. The patients were divided according to the approach into laparoscopic (n = 11) and open (n = …


A Dataset-Centric Analysis Of Evaluation Protocols In Face Morph Attack Detection, Sheerko R. Hmasalah, Abdulbasit K. Al-Talabani, Aras T. Asaad Jan 2026

A Dataset-Centric Analysis Of Evaluation Protocols In Face Morph Attack Detection, Sheerko R. Hmasalah, Abdulbasit K. Al-Talabani, Aras T. Asaad

Polytechnic Journal

Face morph attack detection (MAD) is often evaluated using datasets collected from diverse sources, created for different purposes, and acquired under varying conditions. This heterogeneity raises questions about how evaluation protocols and dataset characteristics influence reported performance. This work adopts a dataset-centric perspective to analyze the effects of evaluation protocol and dataset composition, including visual quality and morph-to-genuine imbalance, on MAD performance. Experiments are conducted on eight datasets and four morphing techniques using a fixed pipeline evaluated across six backbones, including Vision Transformer (ViT) and five CNN architectures, and ten evaluation scenarios covering homogeneous and heterogeneous cross-morph generalization. Performance is …


Influences On Student College-Major Decision And Satisfaction Rate Among Students In The School Of Agriculture, Danielle Shafer Jan 2026

Influences On Student College-Major Decision And Satisfaction Rate Among Students In The School Of Agriculture, Danielle Shafer

Murray State Theses and Dissertations

The purpose of this study was to determine the factors that influence students to choose agriculture majors and agriculture careers and measure the level of satisfaction with their major based on these influences. There are many factors that influence students to choose a major in college and college-major satisfaction. These influences and satisfaction with major may have an impact on a student’s decision to choose a college career path. Some of the influences mentioned in studies are family, friends, educators, extension programs, clubs, financial, and recruitment efforts. The degree to which each of these influence students may depend on the …


Parent And Family Engagement In Middle Schools: A Qualitative Exploration Of Parent Perspectives And Student Success In West Tennessee, Angela Y. Searcy Jan 2026

Parent And Family Engagement In Middle Schools: A Qualitative Exploration Of Parent Perspectives And Student Success In West Tennessee, Angela Y. Searcy

Murray State Theses and Dissertations

Abstract

Parent and family engagement in middle school has been demonstrated to increase students' academic achievement; however, barriers often prevent parental participation. This study focused on parents' and teachers' perceptions of the parents' role in the educational process and sought to answer research questions about parents' perceptions, parents as equal partners in the educational process, and barriers to parental participation. A qualitative research design was used for the study. Teachers and parents from a middle school in West Tennessee participated in interviews to generate data used in this study. Teachers and parents identified common themes affecting the parent-school partnership, including …


Autotheme: A Multi-Agent Framework For Inductive Thematic Analysis With Llms, Abdullah Wahbeh, Omar El-Gayar, Mohammad Al-Ramahi, Tareq Nasralah, Ahmed Elnoshokaty Jan 2026

Autotheme: A Multi-Agent Framework For Inductive Thematic Analysis With Llms, Abdullah Wahbeh, Omar El-Gayar, Mohammad Al-Ramahi, Tareq Nasralah, Ahmed Elnoshokaty

Research & Publications

Thematic analysis is a qualitative research method used to identify and interpret patterns in textual data. However, it can be time-consuming and challenging to replicate. While recent advancements in large language models (LLMs) and generative AI have enhanced thematic analysis, existing methods often rely on prompt-based interactions and require significant human intervention. This paper introduces an agentic AI framework comprising autonomous, goal-directed agents powered by LLMs to perform inductive thematic analysis with minimal human input. We evaluate the framework using a dataset from a Cognitive Behavioral Therapy (CBT) mobile app and compare the results with those from Latent Dirichlet Allocation …


Blockchain As A Digital Coordination Infrastructure For Project Management: A Systematic Review And Integrative Framework,, Cherie Noteboom, Sai Neelima Seru, Aravindh Sekar Jan 2026

Blockchain As A Digital Coordination Infrastructure For Project Management: A Systematic Review And Integrative Framework,, Cherie Noteboom, Sai Neelima Seru, Aravindh Sekar

Research & Publications

Blockchain technology has gained increasing attention as a digital infrastructure capable of improving transparency, trust, and coordination in complex, multi-organizational project environments. However, existing research on blockchain-enabled project management remains fragmented and industry-focused, providing limited guidance for organizational adoption and integration. This study addresses this gap through a systematic literature review of 29 peer-reviewed studies, following PRISMA guidelines, to examine how blockchain capabilities are incorporated into project management practices across industries and maturity stages.

Grounded in Resource-Based View and Coordination Theory, the analysis employs a feature-to-process mapping approach to link six core blockchain capabilities—decentralization, transparency, immutability, smart contracts, traceability, and …


Drivers And Barriers To Artificial Intelligence Adoption In Agriculture: A Socio-Technical Analysis Of Midwestern United States Farmers., Abeer F. Alkhwaldi, Cherie Noteboom, Amir A. Abdulmuhsin Jan 2026

Drivers And Barriers To Artificial Intelligence Adoption In Agriculture: A Socio-Technical Analysis Of Midwestern United States Farmers., Abeer F. Alkhwaldi, Cherie Noteboom, Amir A. Abdulmuhsin

Research & Publications

The agricultural industry is at a critical juncture, experiencing global pressures in the form of climate volatility, a shortage of labor, and an increase in production costs. Although artificial intelligence (AI) has the potential for revolution due to its predictive analytics and self-controlled machinery, it has not achieved widespread and even distribution for use, especially among small-to-medium-sized farms in the Midwestern United States. This study formulates and empirically examines a comprehensive socio-technical model to determine the drivers and barriers to the adoption of AI in this agricultural region. Based on a synthesized framework of the “Unified Theory of Acceptance and …


Polymeric Micelle In Drug Delivery And Nanotechnology: Preparation Methods And Multifunctional Application, Abhishek Sanjay Patil, Savita Ullegaddi, Nagesh C, Suma N Jan 2026

Polymeric Micelle In Drug Delivery And Nanotechnology: Preparation Methods And Multifunctional Application, Abhishek Sanjay Patil, Savita Ullegaddi, Nagesh C, Suma N

Manipal Journal of Medical Sciences

Nanomedicine, an emerging discipline, integrates nanotechnology with pharmaceutical and biomedical science to develop new drugs and imaging compounds with improved efficacy and safety profiles. One of the most important aspects of this field is the creation of new nano-drug delivery systems (NDDS), which harness the power of nanomaterials to bypass such conventional limitations as poor solubility and instability. One form of NDDS, micelles, have been identified as a viable option, providing a safe and effective means of encapsulating hydrophobic natural products. Self-assembling amphiphilic block copolymers, micelles form a core-shell structure that shields the encapsulated drug from degradation while allowing controlled …


Microsponge Technology: A Comprehensive Review Of Advanced Drug Delivery - From Formulation Science To Therapeutic Applications, Akash Pawar, Nagesh C, Sunil Attimarad, Suma Naduvinamani, Savita Ullegaddi Jan 2026

Microsponge Technology: A Comprehensive Review Of Advanced Drug Delivery - From Formulation Science To Therapeutic Applications, Akash Pawar, Nagesh C, Sunil Attimarad, Suma Naduvinamani, Savita Ullegaddi

Manipal Journal of Medical Sciences

Microsponge technology has emerged as a promising drug delivery system due to its unique porosity structure, linked pores and large surface area. These features allow effective drug loading, encapsulation, and sustained drug release, making microsponges suitable for pharmaceutical and cosmetic applications. Their structural integrity provides controlled release profile and prevents deep penetration, localizing drugs in the epidermis. Its versatility allows incorporation into topical and oral forms, addressing limitations of traditional systems such as unwanted side effects, greasiness, or odor. Multiple fabrication methods including liquid–liquid suspension polymerization and quasi-emulsion techniques produce robust, cost-effective microsponges. Standard evaluation includes particle size, drug loading, …


Some Assembly Required V2, Richmond Center For Visual Arts Jan 2026

Some Assembly Required V2, Richmond Center For Visual Arts

Gwen Frostic School of Art Exhibitions

Presented in conjunction with the WMU Special Collections and the Kalamazoo Book Arts Center, where additional works by Chen are on display, this exhibition highlights handmade artist’s books in a variety of formats. The works featured here are permanently housed at the Zhang Legacy Collections Center at Western Michigan University.


Some Assembly Required V1, Richmond Center For Visual Arts Jan 2026

Some Assembly Required V1, Richmond Center For Visual Arts

Gwen Frostic School of Art Exhibitions

Presented in conjunction with the WMU Special Collections and the Kalamazoo Book Arts Center, where additional works by Chen are on display, this exhibition highlights handmade artist’s books in a variety of formats. The works featured here are permanently housed at the Zhang Legacy Collections Center at Western Michigan University.


Does Utilization Of Education In The Rural North Carolina Christian Community Reduce Vitamin D Deficiency, Alyssa Dedmon Jan 2026

Does Utilization Of Education In The Rural North Carolina Christian Community Reduce Vitamin D Deficiency, Alyssa Dedmon

Doctor of Nursing Practice Projects

Background: Vitamin D deficiency is a prevalent and underrecognized health issue, especially office workers who are exposed to less midday sun. Education and awareness may help address this risk.

Purpose: This project aimed to evaluate whether education on light therapy and vitamin D supplementation improves knowledge related to prevention and management of deficiency.

Methods: Participants from a rural North Carolina church community completed a pre-test, viewed an educational video, and completed a post-test to assess changes in knowledge. The intervention addressed risk factors, cultural influences, and treatment options.

Results: Participants demonstrated strong baseline knowledge, with modest improvements post-intervention, particularly in …


Human Trafficking: The Lack Of Education In The Christian Community, Sabrina L. Locklear Jan 2026

Human Trafficking: The Lack Of Education In The Christian Community, Sabrina L. Locklear

Doctor of Nursing Practice Projects

One of the most serious public health problems in the United States, as well as worldwide, is human trafficking. This criminal activity affects over 25 million adults and children worldwide annually (Olivieri et al., 2024). One of the largest allies against human trafficking is faith-based communities. These organizations have strong relationships with the community and play a major role as key stakeholders in the fight against human trafficking (Hounmenou, 2023). The Christian Community is a service-driven group that helps those who are in destitution. Evangelical Christian Pastors in the United States Midwest acknowledge that their congregations struggle when they try …


The Effectiveness Of Cardiovascular Disease Education In The African American Church With African American Women, Aricka H. Thurman Jan 2026

The Effectiveness Of Cardiovascular Disease Education In The African American Church With African American Women, Aricka H. Thurman

Doctor of Nursing Practice Projects

Cardiovascular disease in African American women is one of the leading causes of death in the United States and in rural communities due to the lack of awareness and prevention of the disease. Many African American women are the foundations of their homes and community, and any signs of weakness, including sickness, deteriorates which is why many do not seek attention until it is too late. Educating African American women on the importance of preventive and medical care is essential.

Regardless of the associated stigma of the African American woman and their “superpower” and that they can do “all things” …


Use Of Non-Invasive Testing In Primary Care For Earlier Diagnosis Of Liver Fibrosis, Amy L. Cable Jan 2026

Use Of Non-Invasive Testing In Primary Care For Earlier Diagnosis Of Liver Fibrosis, Amy L. Cable

Doctor of Nursing Practice Projects

Chronic liver diseases, particularly those driven by metabolic risk factors, are frequently under-recognized in primary care settings until they reach advanced stages. Systematic screening using non-invasive testing is inexpensive and convenient, but baseline calculations remain low. The objective of this quality improvement project was to increase primary care providers' knowledge of early fibrosis identification and intent for utilization of testing. Pre- and post-intervention data were collected over a 16-week period. Post-intervention, providers' knowledge of non-invasive testing was improved by 28% and intention of utilization by 80%.


Closing The Gaps: Improving Opioid Overdose Prevention In African American Communities Through Education And Community Engagement, Tara Clinding Jan 2026

Closing The Gaps: Improving Opioid Overdose Prevention In African American Communities Through Education And Community Engagement, Tara Clinding

Doctor of Nursing Practice Projects

African Americans continue to experience high rates of opioid mortality, emphasizing the need for culturally relevant community education and overdose prevention strategies. The purpose of this Doctor of Nursing Practice (DNP) quality improvement project was to implement and evaluate community-based opioid overdose prevention education designed for individuals with substance use disorder, family and friends, and community members. Guided by Betty Neuman’s Model, the education focuses on recognizing opioid overdoses, administering naloxone when indicated, and identifying community treatment and recovery resources. A pre- and post-test design was used to evaluate changes in participants' knowledge and confidence following a structured educational session. …


Every Time The Beat Drops, What Does Your Heart Sing About You? Exploring Black Men’S Cardiac Health, Bianca S. Washington Jan 2026

Every Time The Beat Drops, What Does Your Heart Sing About You? Exploring Black Men’S Cardiac Health, Bianca S. Washington

Doctor of Nursing Practice Projects

The disparities Black men continue to face in rural areas in relation to higher rates of cardiovascular disease, uncontrolled hypertension, and cardiovascular mortality in comparison with other racial groups in the United States continue to be disproportionate. The disparities are influenced by limited access to healthcare, socioeconomic barriers, and structural racism within the health care system. Addressing these issues requires culturally tailored, evidence-based practice interventions that would help restore trust and hopefully engage patients to follow up with primary care providers and to take prescribed medication as directed for cardiovascular disease management. The purpose of this project was to examine …


Breathing Calm Into Testing: The Impact Of Mindfulness Meditation And Aromatherapy On Stress And Test Anxiety Of Prelicensure Nursing Students, Valerie A. Doig Jan 2026

Breathing Calm Into Testing: The Impact Of Mindfulness Meditation And Aromatherapy On Stress And Test Anxiety Of Prelicensure Nursing Students, Valerie A. Doig

Doctor of Nursing Practice Projects

Nursing education is inherently rigorous, with students frequently subjected to high-stakes clinical assessments, simulations, and academic evaluations. Stress and test anxiety can impact learning, which can result in students’ inability to progress in nursing programs. This DNP project aimed to evaluate the effects of aromatherapy with lavender essential oil and meditation on the stress and test anxiety scores in associate degree nursing students through assessing the Perceived Stress Scale (PSS) and Westside Test Anxiety Scale (WSTA) scores. Participants engaged in educational and interventional sessions that utilized aromatherapy and meditation. Surveys were deployed to gather baseline PSS and WSTA scores and …


Implementing A Peer Support Team To Address Workplace Violence: Enhancing Healthcare Worker Well-Being And Retention, Christina Liverman Jan 2026

Implementing A Peer Support Team To Address Workplace Violence: Enhancing Healthcare Worker Well-Being And Retention, Christina Liverman

Doctor of Nursing Practice Projects

Workplace violence is a persistent challenge in healthcare and is associated with decreased psychological well-being, increased emotional distress, burnout, and staff turnover among nurses. Healthcare organizations are increasingly seeking evidence-based interventions to support employees following workplace violence incidents. The purpose of this quality improvement project was to implement and evaluate a peer support program for medical-surgical staff following workplace violence incidents and to examine its effect on perceived psychological well-being.

A nonrandomized pre-test/post-test quality improvement design was implemented on a 38-bed medical-surgical unit in a rural community hospital. Registered nurses, licensed practical nurses, and certified nursing assistants were invited to …


A Systematic Review On Niosomes: Composition, Preparation, And Applications, Sanket Gawade Mr., Sunil Attimarad, Vishakha Desai Ms. Jan 2026

A Systematic Review On Niosomes: Composition, Preparation, And Applications, Sanket Gawade Mr., Sunil Attimarad, Vishakha Desai Ms.

Manipal Journal of Medical Sciences

Conventional drug carrier systems are restricted owing to poor bioavailability, weak stability and non-specific localization, which causes systemic toxicities and reduced therapeutic efficacy. Niosomes, one of the nonionic surfactant vesicular systems, have been suggested that value to overcome these constraints. In this review, we give an account of recent progress in niosome research, highlighting their merits, composition, characterization, and applications.

Niosomes offer several advantages including increased drug bioavailability, targeted delivery and reduced toxicity. Bilayered niosomes can entrap both hydrophilic and lipophilic drugs, therefore allowing simultaneous delivery of actives components. We provide an overview of various techniques for niosome preparation including …


The Impact Of Sports Betting Legalization On Marital Status, Hosea Gitonga Njogu Jan 2026

The Impact Of Sports Betting Legalization On Marital Status, Hosea Gitonga Njogu

Theses and Dissertations

This study examines the causal Impact of sports gambling legalization on marital stability in the United States using data from the Current Population Survey Annual Social and Economic Supplement (CPS-ASEC) and the American Community Survey (ACS) from 2013 to 2024. The analysis leverages variation in the staggered adoption of state-level sports gambling laws and applies two-way fixed effects, event-study, and the Callaway and Sant’Anna (2021) difference-in-differences estimators, controlling for geographic and individual characteristics. Legalization increases divorce rates by 0.42 percentage points in the CPS and 0.51 percentage points in the ACS, corresponding to increases of 2.4% and 2.6%, or approximately …


Managing Multi-Drug Resistance: An Evolutionary Game Theory And Optimal Control Approach, Shukhrat Nasrulloev Jan 2026

Managing Multi-Drug Resistance: An Evolutionary Game Theory And Optimal Control Approach, Shukhrat Nasrulloev

Theses and Dissertations

Multi-drug resistance is an evolutionary process in which treatment eliminates sensitive cells, allowing resistant clones to dominate. This thesis investigates this process using a framework integrating population dynamics, evolutionary game theory, and optimal control theory. We develop a two-population logistic growth model describing competition between drug-sensitive and drug-resistant cells under treatment, construct dose-dependent payoff matrices and replicator dynamics to characterize evolutionary competition, and derive a critical drug level Dcrit = (rS - rR)/(dS - dR) at which resistant cells gain a fitness advantage. An optimal control problem is formulated via Pontryagin's Maximum Principle to identify schedules …