Digital Commons Network^™

A Comparison Of Poly(Methyl Methacrylate) And Silorane-Based Cements As Carriers For Local Doxorubicin Delivery., Grahmm A. Funk, Elizabeth M. Menuey, Zachary D. Denton, Dalan M. Pittz, Alejandro Parrales, Tomoo Iwakuma, Kathleen V. Kilway, Terence E. Mciff

Manuscripts, Articles, Book Chapters and Other Papers

Orthopedic osteosarcomas and metastatic lesions can be difficult to treat with systemically delivered chemotherapy agents alone. Following removal of the primary tumor, implantation of cement to fill the lesion is often done to stabilize weight-bearing bones. One of the commonly used treatments to address osteosarcoma is systemic delivery of doxorubicin. Therefore, research on the incorporation and release of efficacious doxorubicin for local delivery from cement is important. Poly(methyl methacrylate) (PMMA)-based bone cements are the gold standard in orthopedics but have inherent disadvantages. Efforts to overcome some of these deficiencies led to the development of a novel silorane-based biomaterial (SBB). This …

Las Dos Teresas: How Women’S Critiques Of Imperialism And Patriarchy Transformed The Spanish Anarchist Movement, Stephanie Mendez

Women, Gender, and Sexuality Studies Undergraduate Honors Theses

The central question my thesis explores is how women’s participation in the Spanish anarchist movement in the late nineteenth century to early twentieth century transformed the meaning of anarchism and the anarchist movement. The anarchist movement failed to adequately acknowledge structural inequality between men and women. Women anarchists, such as Teresa Claramunt and Teresa Mañé, acknowledged this discrepancy by reimagining the practice of anarchism. They argued for the genuine expression of total liberation. This could only be achievable through the recognition of women’s subordination. They critiqued the role of patriarchy in maintaining women’s subordination. Through their vision for total liberation, …

15-Last Lecture, Heinrich Blücher

Bazelow Transcripts

Heinrich Blücher’s Last Lecture, transcript edited by Alexander Bazelow, presents a sweeping philosophical reflection on meaning, freedom, nihilism, and the unfinished task of humanity. Confronting the modern experience of meaninglessness—especially among the young—Blücher argues that philosophy’s enduring task is the transformation of life into meaningful existence through conscious thought and responsible action. He traces the historical development of nihilism and metaphysical belief from ancient myth, through Greek philosophy, Christianity, and modern systems culminating in Hegel, Marx, Kierkegaard, and Nietzsche, whom he treats as prophetic figures of the modern crisis. Blücher criticizes the deification of history, science, power, and ideology, insisting …

The Protective Power Of Psychological Resources In Mitigating Burnout And Enhancing Flourishing, Dylan R. Polkinghorne, David J. Radosevich, Deirdre M. Radosevich, Dianne D. Murphy, Laken James, Sue S. Craver

Management Faculty Research and Publications

Purpose

This study explores how burnout mediates the relationships between critical psychological resources, specifically resilience, flow and self-efficacy, and flourishing in contemporary work environments.

Design/methodology/approach

Data from 374 participants, including undergraduate students at a regional comprehensive university in the Midwest and full-time working adults in the USA, were analyzed using mediation analysis in MPlus 8.11 to assess the indirect and direct effects among burnout, psychological resources and flourishing in a work environment.

Findings

Results indicate that self-efficacy significantly predicts lower burnout levels and higher flourishing. Resilience and flow were negatively associated with burnout, reducing its impact; however, the direct effects …

Mapping Functional Connectivity In The Pigeon Brain With Wide-Field Optical Imaging, Kathryn C Chenard, Annie R Bice, Seana H Bice, Joseph P Culver, Paula Gerliz, Xavier Helluy, Onur Güntürkün, Jason W Trobaugh, Mehdi Behroozi, Carlos A Botero

2020-Current year OA Pubs

SIGNIFICANCE: Adapting optical imaging technology to avian models can overcome many limitations imposed by functional magnetic resonance imaging (fMRI), which currently restricts the number of species used to study functional connectivity. Developing advanced technology to expand the diversity of species that can be effectively imaged is crucial for addressing significant questions that are currently unreachable, such as understanding the evolution of cognition from a comparative perspective.

AIM: We assessed the potential of optical imaging technology to measure functional connectivity in birds, utilizing pigeons as an avian model. We evaluated whether we could partition the dorsal surface of the pigeon brain …

The Impact Of Fixation Method And Surgical Approach On Outcomes Following Hip Hemiarthroplasty For Femoral Neck Fracture, Brian D Rust, Mitchel R Obey, Jenna-Leigh Wilson, Christopher M Mcandrew, Marschall B Berkes

2020-Current year OA Pubs

INTRODUCTION: Hip hemiarthroplasty is commonly performed for displaced femoral neck fractures in older adults, with implants placed either cemented or uncemented. While cemented fixation offers immediate stability, uncemented fixation reduces operative time and pulmonary complications. Large single-center analyses comparing these techniques remain limited, and this study aims to assess this.

METHODS: We conducted a retrospective case-control study of 634 adult patients undergoing hip hemiarthroplasty at a single Level 1 trauma center from 2019 to 2025. Patients were classified by cemented (n=403) or uncemented (n=231) fixation and further stratified by surgical approach (anterolateral vs posterior). Outcomes included length of stay, postoperative …

Foot-Specific Exercise Intervention For Forefoot Deformity In Individuals With Type 2 Diabetes And Peripheral Neuropathy: A Randomized Controlled Clinical Trial With 3-Year Follow-Up, J A Zellers, K Steger-May, P K Commean, H-J Jeong, E M Bullard, M J Mueller, M K Hastings

2020-Current year OA Pubs

BACKGROUND: Diabetes with peripheral neuropathy can lead to metatarsophalangeal joint (MTPJ) deformity. The purpose of this study was to estimate the effect of a foot-specific intervention on MTPJ deformity. Secondary aims were determining MTPJ deformity progression over 3 years and predictors of MTPJ deformity progression.

METHODS: Sixty people with type 2 diabetes and peripheral neuropathy were recruited for this randomized controlled clinical trial. Participants were assessed at baseline, 6 months (post-intervention), 1.5 years, and 3 years. A 6-month, foot-specific intervention in the experimental group was compared to a shoulder intervention in the control group. The primary outcome was change in …

Beyond Restless Sleep: A Cross-Sectional Study Of Obstructive Sleep Apnea Risk, Aging Biomarkers, And Chronic Low Back Pain, Khalid W Freij, Fiona Bat Agbor, Philemon Domoyeri, Kiari R Kinnie, Asia M Wiggins, Demario S Overstreet, Tammie L Quinn, Shivraj S Grewal, S Justin Thomas, Walid W Freij, Shameka L Cody, Michael A Owens, Robert E Sorge, Burel R Goodin, Edwin N Aroke

2020-Current year OA Pubs

This secondary data analysis aimed to determine the nature of the relationship between obstructive sleep apnea (OSA) risk, biological age acceleration, and nonspecific chronic low back pain (CLBP). In total, 199 adults aged 18-82 years who filled both STOPBANG and pain questionnaires subsetted for secondary analysis. Based on the STOPBANG questionnaire, 104 had a low OSA risk and 95 had an intermediate or high OSA risk. Dunedin Pace of Aging Computed from the Epigenome (DunedinPACE), Horvath's, Hannum's, PhenoAge, and GrimAge clocks were used to determine biological age and pace of biological aging. Individuals with low OSA risk reported increased DunedinPACE …

Lost Before Forgetting: Objective Driving Metrics Track Navigation Deficits Tied To Preclinical Alzheimer's Disease, Yiqi Zhu, Ramkrishna K Singh, Semere Bekena, David C Brown, Chen Chen, Matthew Blake, Jean-François Trani, Ganesh M Babulal

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: Navigation is a complex, multisensory process in which subtle changes may emerge before the onset of symptomatic Alzheimer's disease (AD). This study investigated whether navigation abilities were associated with amyloid and tau pathology in cognitively normal older adults.

RESEARCH DESIGN AND METHODS: Among 285 cognitively unimpaired older adults, navigation and objective driving behaviors were assessed using the self-reported Santa Barbara Sense of Direction Scale (SBSOD) and a datalogger, respectively. Amyloid and tau burden were quantified using PET-MRI 2 years post-initial driving data collection. Linear mixed-effects models were used to evaluate the associations between biomarker status and longitudinal …

Managing Human Sources: Identification And Management Of Motivation, Tiffany Mckenzie, Pamela Henry, Nikki Rajakaruna

Research outputs 2022 to 2026

Human Source management is a critical function of intelligence and evidence collection by law enforcement and intelligence agencies across the world. Understanding the motivations of Human Sources is key to gaining high intelligence yields. Yet research which explores Human Source motivation, from a handler’s perspective, is limited. Even more limited is research which considers how motivation is identified and managed by law enforcement agencies across the course of a Human Source’s engagement with an agency. This research explores the experiences and perceptions of Human Source handlers from two Australian law enforcement agencies via semi-structured interviews (N = 17). Handlers highlighted …

Persistence Of Contested Value Cocreation Practices, Kim Feddema, Kaisa Koskela-Huotari, Paul Harrigan

Research outputs 2022 to 2026

The climate crisis and other global challenges make it clear that not only are new value cocreation practices (VCPs) needed, but some current VCPs must be discontinued. Prior service literature assumes that VCPs can be disrupted by reforming the institutions that govern them. However, empirical observations show that VCPs may persist even when targeted by institutional work, and recent organizational research points to contested practices that continue to be enacted even when challenged or criticized. To understand this phenomenon in value cocreation, we conducted an embedded case study of exotic pet-keeping—a set of VCPs that continue despite intervention efforts. Our …

Optimizing Ucs Prediction Models Through Xai-Based Feature Selection In Soil Stabilization, Ahmed Mohammed Awad Mohammed, Omayma Husain, Mosab Hamdan, Abdalmomen Mohammed, Abdullah Ansari, Atef Badr, Abubakar Elsafi, Abubakr Siddig

Research Outputs: 2025-Present

Unconfined Compressive Strength (UCS) is a key parameter for the assessment of the stability and performance of stabilized soils, yet traditional laboratory testing is both time and resource intensive. In this study, an interpretable machine learning approach to UCS prediction is presented, pairing five models (Random Forest (RF), Gradient Boosting (GB), Extreme Gradient Boosting (XGB), CatBoost, and K-Nearest Neighbors (KNN)) with SHapley Additive exPlanations (SHAP) for enhanced interpretability and to guide feature removal. A complete dataset of 12 geotechnical and chemical parameters, i.e., Atterberg limits, compaction properties, stabilizer chemistry, dosage, curing time, was used to train and test the models. …

Smart Biosensing Nanomaterials For Alzheimer’S Disease: Advances In Design And Drug Delivery Strategies To Overcome The Blood–Brain Barrier, Manickam Rajkumar, Furong Tian, Bilal Javed, Bhupendra G. Prajapati, Paramasivam Deepak, Koyeli Girigoswami, Natchimuthu Karmegam

Research Outputs: 2025-Present

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by persistent memory impairment and complex molecular and cellular pathological changes in the brain. Current treatments, including acetylcholinesterase inhibitors and memantine, only help with symptoms for a short time and do not stop the disease from getting worse. This is mainly because these drugs do not reach the brain well and are quickly removed from the body. The blood–brain barrier (BBB) restricts the entry of most drugs into the central nervous system; therefore, new methods of drug delivery are needed. Nanotechnology-based drug delivery systems (NTDDS) are widely studied as a potential …

Development Of An Active Crosslinked Nanocomposite Film Based On Gelatin-Ethyl Cellulose, Trans-Cinnamaldehyde, And Silver Nanoparticles For The Preservation Of Sliced Meat, Elham Sarmast, Shiv Shankar, Stephane Salmieri, Sahra Amel Rahmouni, Monique Lacroix

Research Outputs: 2025-Present

This study aimed to develop a novel bioactive biobased packaging film combining gelatin (G) and ethyl cellulose (EC), cardanol and glycerol as plasticizers, trans-cinnamaldehyde (TCA) as a crosslinker/bioactive compound, and silver nanoparticles (AgNPs) as bioactive agents. The degree of crosslinking, mechanical and thermal properties, water solubility (WS), and water vapor permeability (WVP) of the films were analyzed. Molecular interactions within the film matrix were determined by FTIR spectroscopy. The G-EC film, in a 1:2 weight ratio, exhibited improved physicochemical properties compared to the pure G film, with a low WS (7.8%). The incorporation of TCA and AgNPs—to form bioactive nanocomposite …

Ocular Dominance Is Associated With Interocular Asymmetry In Refractive Error And Axial Length Across Childhood And Early Adulthood, Síofra C. Harrington, Gareth Lingham, James Loughman, Ian Flitcroft, David A. Mackey, Michael Moore

Research Outputs: 2025-Present

Purpose: To determine whether ocular dominance is associated with systematic interocular asymmetry in spherical equivalent refraction (SER) and axial length (AL) across childhood and early adulthood, and assess whether such asymmetry exceeds laterality effects. Methods: Data were analysed from three population-based cohorts: 728 children (6–7-year-olds) and 898 adolescents (12–13-year-olds) from Ireland and 303 young adults (25–30-year-olds) from Western Australia. Ocular dominance was assessed using sighting tests. SER was measured by cycloplegic autorefraction and AL by optical biometry. Interocular differences were evaluated using paired comparisons, concordance correlation coefficients (CCC), Deming regression, Bland–Altman analyses and mediation modelling. Analyses were stratified by refractive …

Exploring The Postpartum Recovery After Hyperemesis Gravidarum: A Qualitative Study, Zeinab El-Dirani, Sergio A. Silverio, Eleni Niarchou, Elana Payne, Pauline Dunne, Melanie Nana, Catherine Williamson, Mary F. Higgins, Eileen O'Brien, Joan Devin, Aisling Walsh, Angela C. Flynn

Research Outputs: 2025-Present

Introduction: Hyperemesis Gravidarum affects 0.3–3.6% of women during pregnancy and has a significant impact on maternal health. Investigation of both the immediate and longer-term effects remains a high research priority. However, there is limited research on postpartum recovery after hyperemesis gravidarum. Aim: To explore the postpartum recovery experiences of women who had hyperemesis gravidarum. Methods: A large descriptive qualitative study was conducted using semi-structured interviews to explore the postpartum experiences of women who had hyperemesis gravidarum within the previous 5 years in Ireland. Data were analysed using reflexive thematic analysis. Results: Forty-one women participated, and four themes were identified: (1) …

Axial Length To Corneal Curvature Ratio Is Insufficient For Detecting Pseudomyopia In Children: A Multi-Cohort Study, The Cream-Kids Consortium, Huyen T. Bui, Dirk J. Van Hemert, Tianli Peng, Shuhui Yang, Hai Yen T. Nguyen, Hannah Noor, Siofra C. Harrington, Sander C.M. Kneepkens, Lene A. Hagen, Craig S. Walker, Edward Mallen, Matthew Cufflin, Rigmor C. Baraas, Neema Ghorbani-Mojarrad, Olavi Pärssinen, Louise Terry, Shi Ming Li, Amanda N. French, Jason C. Yam, Caroline C.W. Klaver, Jeremy A. Guggenheim

Research Outputs: 2025-Present

Purpose: Pseudomyopia is an accommodative disorder that can be identified by the difference between pre- and post-cycloplegic refractive error. The current study aimed to evaluate whether the axial length to corneal curvature (AL/CR) ratio, in conjunction with non-cycloplegic refractive error, can reliably identify pseudomyopia in children, thus avoiding the need for cycloplegia. Methods: Refractive error and biometry data from longitudinal studies based in Denmark (n = 645; age 7–17 years) and China (Anyang Childhood Eye Study; n = 2487; age 6–13 years) were used to train separate linear mixed models for children of European or East Asian ancestry, respectively, with …

Agriculture Contributions To Water Pollution And Sustainable Policy Solutions In Europe, Jemma Nolan, Azza Silotry Naik

Research Outputs: 2025-Present

Freshwater is essential for sustaining the health of humans, animals, and ecosystems; however, agricultural activities remain a major source of water pollution globally. This review examines how crop production, livestock farming, and aquaculture contribute to water contamination, the effectiveness of current European policies, and the potential of sustainable mitigation strategies. Evidence from the research identified pesticides, herbicides, veterinary antibiotics, nutrient runoff, aquaculture effluents, and microplastics as the primary agricultural pollutants affecting surface and groundwater quality. These contaminants have been linked to ecosystem degradation, biodiversity loss, endocrine disruption, antimicrobial resistance, and adverse human health outcomes. Despite extensive regulatory frameworks, including the …

Optimizing Marketing Campaigns To Maximize The Response Rate For A Supermarket Using Machine Learning Techniques, Alia Almansoori

Theses

Supermarkets must improve their marketing tactics at a time of changing consumer behavior and increasing competition in the retail industry. Engaging the wide and sophisticated consumer base of today's supermarkets is difficult using traditional methods. This proposal presents a data-driven approach using cutting-edge machine learning methods to enhance supermarket marketing strategies. The main goal is to increase the response rate of marketing initiatives, which will improve consumer engagement and ultimately increase revenue. Additional primary objectives are customer segmentation and targeting, predictive modeling, personalization, ongoing performance monitoring, and ROI evaluation. The current problem centers around personalization and accuracy. Due to the …

The Impact Of Artificial Intelligence And Technology On Online Learning In The Higher Education Sector, Afra Alqemzi

Theses

The integration of Artificial Intelligence (AI) and technology into education has become an inseparable part of online education transforming the landscape of the higher education, which has provided a chance to experience flexible learning patterns according to personal needs, individualized and optimized instruction strategies and more effective and purposeful student involvement. Knowing how such technologies evolve in institutions with increasing implementation of AI-driven platforms is therefore critical to strategic and long-term planning. This paper aims at examining the effects of AI in the advancement of online learning in higher education, including the following aspects; improvements of outcomes, compliance with the …

Tranquil Talismans, Yayan Zhang

Theses

My series aims to delve deep into my personal experiences, narrating the uncertainty of graduating, the imbalance between study and work, and the anxiety brought about by countless rejections that have gradually disrupted the rhythm of my life. This disruption manifests in physiological symptoms such as insomnia, irregular menstrual cycles, emotional fluctuations, and the discovery of bodily lumps.My thesis work is separated into three parts of my journey. The first part portrays a dark period marked by chaos and confusion as I underwent a transition in my social roles and visually metaphorizes the onset of anxiety as darkness and chaos …

Poor Brain Reserve Increases Mortality Risk In Glioblastoma, Sree Gongala, Pamela Lamontagne, Danial Marcus, Et Al.

2020-Current year OA Pubs

BACKGROUND: Brain reserve refers to the structural capacity of the brain and correlates with age and Karnofsky Performance Status (KPS). While age and KPS are known independent predictors of survival in glioblastoma patients, the role of brain reserve in influencing glioblastoma outcomes remains unexplored. This study investigates the relationship between baseline brain-reserve metrics and survival outcomes in isocitrate dehydrogenase 1-wildtype (IDH1-WT) glioblastoma.

METHODS: We analyzed 841 patients with IDH1-WT glioblastoma using clinical data and presurgical MR images sourced from 4 institutions. MRI-based tumor characteristics and quantitative brain-reserve metrics were assessed using the Cancer Imaging Phenomics Toolkit and the Computational Anatomy …

Alzheimer's Disease Heterogeneity And Co-Pathologies: Defining Novel Targets, Biomarkers, Modalities, And Research Methodologies, Malú Gámez Tansey, Jorge J Llibre-Guerra, Suzanne E Schindler

2020-Current year OA Pubs

Alzheimer's disease (AD) is a biologically heterogeneous condition with vascular, proteinopathic, metabolic, and immune processes jointly shaping its clinical expression, trajectory of progression, and response to therapeutic intervention. Common AD co-pathologies such as cerebral amyloid angiopathy, Lewy body pathology, α-synuclein, and transactive response DNA-binding protein of 43 kDa (TDP-43)/limbic-predominant age-related TDP-43 encephalopathy are also increasingly connected with cognitive decline and therapeutic response. Significant advances in biomarkers, including seed amplification assays, proteomic signatures, and emerging positron emission tomography tracers bolster the field's understanding of a biological staging model and discovery of previously unrecognized co-pathologies. The Fall 2025 Alzheimer's Association Research Roundtable …

Perception Of Dementia Risk Among Black Adults: An Ecological Analysis Of Causal Loop Diagrams With A Structural And Social Determinant Of Health Composite Index, Jean-Francois Trani, Ramkrishna K Singh, Alexis Ib Walker, Semere Bekena, Yiqi Zhu, Ganesh M Babulal, Robbie Hart

2020-Current year OA Pubs

INTRODUCTION: To investigate drivers of dementia risk disparities among older Black Americans using a community-based system dynamics (CBSD) approach.

METHODS: Over 18 months, 234 participants created 36 causal loop diagrams (CLDs) on dementia risk. An ecological analysis compared structural differences across groups based on scores on a structural and social determinants of health composite index (S/SDOH-CI).

RESULTS: Groups in the highest SDOH-CI quantile were more likely to identify key protective pathways linking mental health, substance use, exercise, medication, and community support to reduce dementia risk. In contrast, fewer than 25% of low-SDOH-CI groups identified these connections, and under 15% recognized …

Development Of Colonic Polyposis In A Woman With Chronic Myeloid Leukemia Treated With Dasatinib, Guido Pelaez, Behram Suha Yildiz, Mert Candan, Mohammad Ismail, Francesca Vacca, Marianna B Ruzinova, Samuel Ballentine, Kathleen Byrnes, Armin Ghobadi

2020-Current year OA Pubs

INTRODUCTION: Chronic myeloid leukemia (CML) is a hematopoietic malignancy driven by constitutive tyrosine kinase activity. Dasatinib, a second-generation (2G) tyrosine kinase inhibitor (TKI), is a preferred treatment due to its superior, durable, and rapid response rates. While dasatinib has known gastrointestinal (GI) side effects, colonic polyposis is a rare complication, not well described in the literature.

CASE PRESENTATION: Upon routine colonoscopy, a 66-year-old woman with chronic-phase CML was incidentally discovered to have asymptomatic colonic polyposis after 11 months of dasatinib therapy. Histopathology revealed reactive inflammatory changes without evidence of dysplasia or neoplasia. The polyposis resolved completely after cessation of dasatinib. …

Treating Alzheimer's Disease In A Person Living With Hiv, David B Clifford, Tammie L S Benzinger, Jee-Young Han, Savannah Powles, Madeline Paczynski, Beau M Ances, J William Campbell

2020-Current year OA Pubs

INTRODUCTION: Human immunodeficiency virus (HIV) therapies now support survival into advanced ages by suppressing HIV replication and preserving immune function. Alzheimer's disease (AD), the most common neurologic degenerative condition, may now be treated with anti-amyloid therapies (AAT). HIV was an exclusionary criterion in clinical trials for AAT, leaving the safety and efficacy of these medications unknown in this setting.

METHODS: We report the development of AD supported by careful evaluations and biomarkers over a 10-year period in a person living with well-controlled HIV infection.

RESULTS: AD was diagnosed with consistent clinical and biomarker evidence. AAT was successfully administered without complications. …

Biological Aging Acceleration In Major Depressive Disorder: A Multi-Omics Analysis, Breno Satler Diniz, Shangshu Zhao, Gabin Drouard, Eero Vuoksimaa, Miina Ollikainen, Eric J Lenze, Ming Xu, Richard H Fortinsky, George A Kuchel, Jaakko Kaprio, Chia-Ling Kuo

2020-Current year OA Pubs

Major depressive disorder (MDD) is linked to a higher risk of premature aging, but the mechanisms underlying this association remain unclear. Using data from two population cohorts (UK Biobank and Finnish Twin Cohort), we evaluate the relationship between systemic and organ-specific proteomic and epigenetic aging acceleration and MDD. A lifetime history of MDD was associated with accelerated proteomic aging at both systemic and organ-specific levels-including the brain-in both cohorts, with stronger associations than those observed with systemic epigenetic aging. Systemic and brain-specific proteomic aging acceleration were linked to higher risks of incident MDD and a greater risk of Alzheimer's disease, …

The Impact Of Congenital Heart Disease On The Timing Of Alzheimer's Disease In Down Syndrome, Julianne G Clina, Beau Ances, Et Al.

2020-Current year OA Pubs

INTRODUCTION: The incidence of Alzheimer's disease (AD) in Down syndrome (DS) exceeds 90%. Approximately 50% of people with DS have congenital heart disease (CHD). Having CHD increases risk for early-onset AD in populations without DS, but it is unclear if CHD influences AD in DS.

METHODS: Data from the Alzheimer Biomarker Consortium-Down Syndrome (ABC-DS) were used. Participants with CHD (

RESULTS: People with CHD scored lower for visuospatial ability (

DISCUSSION: Presence of CHD may influence AD progression in DS.

HIGHLIGHTS: In adults with Down syndrome (DS), those with congenital heart disease (CHD) had higher amyloid beta and reached the …

Antihypertensive Medications And Risk Of Alzheimer's Disease: Evidence For Specific Medication Use, Osvaldo J. Laurido-Soto, Alejandra Camacho-Soto, Irene M. Faust, Kassu M. Beyene, Aaron Katz, Jordan A. Killion, Brad A. Racette

2020-Current year OA Pubs

No abstract provided.

Effect Of A Pregnancy Lifestyle Intervention Embedded Into A Home Visiting Program On Child Neurodevelopment, Sarah S Farabi, Rosemary Bass, Amit Mathur, Cindy Schwarz, Candice Woolfolk, Richard Stein, Samuel Klein, Debra Haire-Joshu, Alison G Cahill

2020-Current year OA Pubs

Maternal obesity is associated with a higher risk of abnormal child neurodevelopment. The aim of this study was to determine the effect of a lifestyle intervention embedded into a home visiting program, Parents as Teachers (PAT), on 18-month neurodevelopment in the offspring. Pregnant women (9-15 weeks) of African American Race, 18-45 years old, first-trimester BMI 25.0-45.0 kg/m