Digital Commons Network^™

Global Value Chains And Economic Inequality, Vivek Soundararajan, Ari Van Assche, Hari Bapuji, Gokhan Ertug

Research Collection Lee Kong Chian School Of Business

In their inaugural editorial, Van Assche and De Marchi (2024) argued that meaningful progress in international business policy requires a more fine-grained understanding of how private international business practices intersect with public policy objectives. This editorial builds on that insight by applying it to a critical yet still underexplored issue – one on which we hope to see more research in this journal: the role of multinational enterprises (MNEs) and global value chains (GVCs) in shaping economic inequality within developing economies. Decisions related to sourcing, contracting, and GVC governance are inherently distributional rather than neutral, with important implications for how …

Unilateral Online Ultrasound Stimulation Of Early Visual Cortex Suppresses Responses To Contralateral Visual Stimuli, Suraya Dunsford, Keith Murphy, Ema Darrieutort, Elsa Fouragnan, Giorgio Ganis

School of Psychology

INTRODUCTION: Transcranial ultrasound stimulation (TUS) shows great promise for inducing neuroplastic changes that persist long after stimulation. Evidence of stimulation-locked (online) neural changes would enable the development of closed-loop application of TUS. However, such responses have been difficult to distinguish from coincident neural activity caused by auditory and somatosensory effects of TUS.

METHODS: To dissociate genuine online neuromodulatory effects from peripheral confounds, we leveraged the contralateral retinotopic organization of the early visual cortex in nineteen subjects. Using a hemifield visual stimulation paradigm combined with high-precision, functional MRI-guided TUS, we applied TUS to the left early visual cortex while participants viewed …

Magnetically Driven Engineering Of Magnetic Hydroxyapatite/Ca Ro Membranes: Enhancing Surface Physicochemical Properties For High-Performance Water Desalination, Fariba Oulad, Ali Akbar Zinatizadeh, Sirus Zinadini, Amir Razmjou, Sara Eavani

Research outputs 2022 to 2026

This research focuses on the development of innovative hydrophilic reverse osmosis (RO) hydroxyapatite/cellulose acetate (HAP/CA) and magnetic-hydroxyapatite (M-HAP)/CA membranes, utilizing a phase-inversion technique with varying nanoparticles (NPs) concentration. The positioning of magneto-responsive M-HAP NPs within the advanced M-HAP/CA membranes was adeptly controlled using magnetic guidance during immersion- precipitation process in a coagulation bath. This precise control enabled a densely organized arrangement of M-HAP NPs, shifting from the membrane's core to its upper separation layer. Consequently, the barrier properties, mechanical integrity, and surface characteristics of the advanced M-HAP/CA membranes saw significant enhancement due to the uniform distribution of hydrophilic porous NPs …

Quality Of Human-Genai Collaboration And Its Driving Factors: A Symbiotic Agency Perspective, Jiayu Shang, Dan Huang, Songshan (Sam) Huang

Research outputs 2022 to 2026

Generative AI (GenAI) is increasingly integrated into users’ daily work as a collaborative partner. Drawing on the symbiotic agency theory, this study investigates the quality of human-GenAI collaboration using a mixed-methods approach, including qualitative interviews and quantitative surveys. Study 1 identified three dimensions of human-GenAI collaboration quality that comprise outcome quality, comfort, and efficiency; and six driving factors which can be categorized under human agency (domain knowledge, desire for control, and domestication ability), and GenAI agency (communication ability, working memory, and long-term memory). Study 2 applied fuzzy-set qualitative comparative analysis (fsQCA) to explore configurations of the driving factors that lead …

An Explainable Transformer-Based Model For Phishing Email Detection: A Large Language Model Approach, Mohammad Amaz Uddin, Md Mahiuddin, Iqbal H. Sarker

Research outputs 2022 to 2026

Phishing email is a serious cyber threat that tries to deceive users by sending false emails with the intention of stealing confidential information or causing financial harm. Attackers, often posing as trustworthy entities, exploit technological advancements and sophistication to make the detection and prevention of phishing more challenging. Despite extensive academic research, phishing detection remains an ongoing and formidable challenge in the cybersecurity landscape. In this research paper, we present a fine-tuned transformer-based masked language model, RoBERTa (Robustly Optimized BERT Pretraining Approach), for phishing email detection. In the detection process, we employ a phishing email dataset and apply the preprocessing …

Influence Of Exercise Training On Nitric Oxide Pathways And Their Physiological Effects, Jonas Benjamim, Stephen J Bailey, Leonardo Da Silva Gonçalves, Mia Burleigh, Mario Siervo, Andrew R Coggan, Raúl Bescos

School of Health Professions

Nitric oxide (NO) is a critical signalling molecule in cardiovascular, metabolic, and muscular function. Endogenous NO production occurs via two primary metabolic pathways: 1) the classical nitric oxide synthases (NOS) pathway, and 2) the alternative (nitrate-nitrite-NO) pathway, in which inorganic nitrate (NO 3 -) is sequentially reduced to nitrite (NO 2 -) and other NO intermediates (e.g., S-nitrosothiol). The latter pathway relies heavily on the oral microbiota, which catalyze the two-electron partial reduction of NO 3 - to NO 2 -, which is influenced by oral physiology, microbial composition and salivary flow. While the role of exercise training in enhancing …

Widespread Decline In The Abundance Of Sea Cucumber Assemblages In Atolls Of The Protected Rowley Shoals, Northwestern Australia, Inês Leal, Claire L. Ross, Simone Strydom, Richard D. Evans, Thomas H. Holmes, Graham J. Edgar, John K. Keesing

Research outputs 2022 to 2026

The Rowley Shoals, off northwestern Australia, are renowned as a biodiversity hotspot. This remote system comprises three atolls, Clerke, Imperieuse and Mermaid, which in recent years have been increasingly targeted by illegal fishing, a pressure rising across the Indo-Pacific. The objective of this study was to quantify recent changes in sea cucumber assemblages across the Rowley Shoals. We surveyed nine sea cucumber species at monitoring sites in 2018 and 2023 to assess changes in their abundance. Total assemblage densities declined significantly across all atolls and habitats. Documented seizures of illegally harvested holothurians by the Australian Fisheries Management Authority over this …

Neutrophil Gelatinase-Associated Lipocalin And Neutrophil-To-Lymphocyte Ratio As Indicators Of Nephropathy In Type 2 Diabetic Mellitus Patients In Ghana: A Case-Control Study, Allwell Adofo Ayirebi, Wina Ivy Ofori Boadu, Stephen Twumasi, Samuel Kwarteng, Benedict Sackey, Lilian Antwi Boateng, Joseph Boachie, Samuel Essien-Baidoo, Daniel Nii Martey Antonio, John Agyemang Sah, Afua Marfowaa, Mayfair Adwapa Mpiani, Joachim Baba Domosie, Abiba Khalifah, Emmanuel Ekow Korsah, Ebenezer Senu, Eugene Arele Ansah, Joseph Yorke, Enoch Odame Anto

Research outputs 2022 to 2026

Introduction: Serum neutrophil gelatinase-associated lipocalin (sNGAL), a renal tubular marker, and neutrophil-to-lymphocyte ratio (NLR), a hematological inflammatory marker are two biomarkers that have recently received attention, because of their association with kidney disease. This study examined the diagnostic value sNGAL and NLR in type 2 diabetes mellitus (T2DM) patients with nephropathy. Materials and Methods: In this hospital-based case-control research, 97 T2DM participants and 70 healthy subjects were included. Participants' information was documented using a structured questionnaire and patient case records. Venous blood was drawn from each participant and early morning midstream urine samples were collected for blood and urine measurements …

Prescribing Tourism: Cultivating Positive Travel Experiences For Individuals With Health Conditions, Fangli Hu, Jun Wen, Sebastian Filep

Research outputs 2022 to 2026

Clinical evidence of tourism's health-related benefits for people with health conditions is notably scarce. Prescribing tourism, wherein medical professionals recommend engaging in tourism activities to enhance overall health and well-being, could offer unique insights into the tourism–health nexus. This paper adopted a conceptual approach, underpinned by a state-of-the-art literature review conducted in accordance with the PRISMA framework to identify knowledge gaps in the existing literature. This paper proposed prescribing tourism as a novel research agenda at the intersection of tourism and health, and further introduced it as a promising approach for people with health conditions, aiming to potentially minimise adverse …

Interest Fit Beyond The Riasec: The Comprehensive Assessment Of Basic Interests-O*Net (Cabin-Net), Chu Chu, Kevin A. Hoff, Zihan Liu, Nicholas F. Heimpel, Anthony Greco, Frederick L. Oswald, James Rounds

Research Collection Lee Kong Chian School Of Business

Over the past half-century, Holland’s RIASEC model has dominated vocational interest research. Although the RIASEC categories effectively capture general occupational themes, their breadth obscures meaningful variability across underlying basic interests, which are more refined interest scales. In this research, we adapted the Comprehensive Assessment of Basic Interests (CABIN; Su et ., 2019) to be used alongside O*NET for assessing interest fit, resulting in the 60-item CABIN-NET that measures 20 basic interest scales organized under RIASEC domains. In Study 1, we refined items for the CABIN-NET using a nationally representative adult sample (N = 768). In Studies 2 and 3, we …

Can’T Get Work Off My Mind: The Effect Of Nonwork Goal Reflection On After-Work Rumination And Well-Being, Trevor A. Foulk, Min-Hsuan Tu, Michael Schaerer, Amber Johnson

Research Collection Lee Kong Chian School Of Business

Many employees lament that their inability to stop ruminating about work during nonwork time is one of their most significant work-related challenges, yet limited research has articulated actionable strategies to address this issue on a day-to-day basis. Integrating goal shielding theory with rumination theory, our model introduces nonwork goal reflection as a deliberate behavioral intervention employees can engage in to curtail work-related rumination, in a way that facilitates well-being during nonwork time. Specifically, we argue that engaging in nonwork goal reflection—where employees intentionally reflect on nonwork goals to be completed during their nonwork time—can curtail work-related rumination and is associated …

Differentiated Instruction For Multilingual Learners: A Thematic Analysis Of Research And Practice, Mohsine Bensaid, Jiayuan Jiang

Journal of English Learner Education

Differentiated instruction (DI) is widely promoted as a means of supporting diverse learners, yet its enactment for multilingual learners (MLs) remains uneven and under-theorized in mainstream classrooms. This study examines how DI is conceptualized and implemented to support MLs by attending to learners’ linguistic, cultural, and academic profiles. Using reflexive thematic analysis, this qualitative synthesis examines 20 peer-reviewed empirical studies published between 2010 and 2024 in English-medium K–12 contexts in the United States, with particular attention to elementary settings when specified. Analytic interpretation was supported by practitioner-based reflection functioning as an interpretive lens rather than a separate data source. Four …

Section 302(A)'S "Arising From" Nexus Element: Need For A Tune-Up In The Aftermath Of Ford Motor?, Michael J. Hutter

Pace Law Review

This article traces the historical development of the “arising out of” and “relate to” nexus requirements, examines the evolution of state long- arm statutes following International Shoe Co., and analyzes the origins and judicial interpretation of C.P.L.R. § 302(a). It argues that New York’s statutory scheme no longer fully reflects the constitutional scope of specific jurisdiction as articulated by the Supreme Court. The article concludes by proposing a legislative amendment to C.P.L.R. 302(a) to add the phrase “relate to,” thereby aligning New York’s long-arm statute with Due Process and better effectuating the statute’s underlying purpose of affording New York residents …

Informing Consumer Product Sound Quality Analysis Using Generative Adversarial Networks, Daniel Jeffery Lesko, Vinh Nguyen

Michigan Tech Publications

Sound quality attributes have been proven important predictors of customer satisfaction with consumer goods and appliances. The results of several studies indicate that level-based, tonal, and temporal aspects of sound influence the perceived quality of consumer products. The current state-of-the-art of inferring consumer satisfaction with sound attributes is based on the jury test methodology. However, product engineers often find the models generated from these studies incomplete, resulting in products that fail to meet consumer expectations. Therefore, this study aims to utilize generative data-driven approaches to create a range of acceptable sound quality attributes given consumer satisfaction requirements. A baseline sound …

Social Media And E-Cigarette Use In Youth: Does Depression Play A Mediating Role?, Soumya Upadhyay, Mohammad Karim, Shivank Chhaya

Healthcare Administration and Policy Faculty Research

About 28% of middle and high school students report the use of e-cigarettes per the 2019 NYTS survey. Social media can seclude a youth into limited set of beliefs, including affirmation for e-cigarette use. Internalizing problems like depression may be due to overuse of social media, and youth with depressive symptoms are more likely to use e-cigarettes to cope. National Youth Tobacco Survey (NYTS) 2023 data was used (n = 18 143) in a cross-sectional design. Ever e-cigarette use was the binary (Y/N) dependent variable. Independent variable, social media use, was categorized as “never,” “nondaily,” “daily.” Mediator variable, presence of …

Exploring The Optimal Age For Total Knee Arthroplasty To Minimize Risk Of Adverse Outcomes: Machine Learning Analysis Of A Statewide Cohort, Chloe Heiting, Yiyuan Wu, Susan M. Goodman, Peter Sculco, Fei Wang, Said A. Ibrahim, Peter Cram, Rich Caruana, Bella Mehta

Department of Medicine Faculty Papers

BACKGROUND: Rates of total knee arthroplasty (TKA) in the United States have risen in patients of a wide age range. Although rates of postoperative TKA complications have decreased, they remain a significant concern. In this study, we aim to determine how the risk of adverse TKA outcomes changes dynamically with age and explore the optimal ages with the lowest risk for adverse outcomes.

METHODS: This retrospective cohort study included patients who underwent elective primary TKA from 2012 to 2018 in the Pennsylvania Health Care Cost Containment Council Database. We trained (70% train:30% test) an explainable boosting machine (EBM), a modern …

Factors Affecting The Adoption Of Artificial Intelligence-Driven Wearable Technology In The Malaysian Healthcare Sector: A Conceptual Framework, Syeda Hafsa Rizwan, Anusuyah Subbarao, Nasreen Khan, Farrukh Ahmed Khan, Shaikh Fazlur Rahman, Nimra Aziz, Syed Muntazir Azhar Shah

International Journal of Management, Finance and Accounting

This conceptual paper examines the adoption of Artificial Intelligence (AI)-driven wearable technology, including smartwatches, fitness trackers, wearable ECGs, glucose monitors, and pain management devices, in transforming healthcare in Malaysia. Despite the extreme potential to enhance patient care and healthcare monitoring, the adoption of AI-driven wearable technology remains limited due to several persistent barriers. The purpose of this study is to examine these challenges and propose a framework to improve the integration of AI-driven wearable technology in Malaysia’s healthcare system. Grounded in the Diffusion of Innovation (DOI) theory, this study examines how five key innovation attributes —relative advantage, compatibility, complexity, trialability, …

Influence Of Time Management Skills And Technostress On Academic Performance Among The Private University Students: A Conceptual Framework, Jogtika Ramasamy, Nasreen Khan Thandar Oo

International Journal of Management, Finance and Accounting

Digital tools enhance learning but can also cause technostress, which can impact focus and academic performance. Balancing technology use with effective time management and social engagement is key to student success. Students in Malaysia's Klang Valley reported increased feelings of loneliness, mental health issues, and technostress, particularly as a result of the shift to online learning. This study aims to propose a conceptual framework based on the Study Demand-Resources Theory, examining how time management skills and technostress dimensions influence academic performance through the mediating role of student engagement. A quantitative and cross-sectional survey will be conducted by distributing Likert scale …

Innovative Approaches To E-Grocery: Analyzing Customer Satisfaction In Facebook Livestream Shopping, Karen Tien Wan Lin, Vincent Oh Kim Seng, Hasliza Hassan, Shaikh Fazlur Rahman

International Journal of Management, Finance and Accounting

The primary objective of this study is to examine the crucial determinants that influence customer satisfaction in Facebook livestream e-grocery shopping in Malaysia, with a particular focus on housewives as a significant consumer segment. A sample of 220 respondents was selected using simple random sampling, and the data was analyzed using the Statistical Package for the Social Sciences (SPSS). The analysis confirms the hypotheses that customer satisfaction in Facebook Livestream e-grocery shopping was influenced by factors such as product quality, security, website design, delivery service and e-service quality. Interestingly, three factors, including information quality, payment method, and product variety, were …

Digital Marketing And Consumer Behaviour In Travel Services: A Conceptual Framework On The Mediating Role Of Brand Trust, Omar Abdulaziz Sultan Abdullah, Junainah Binti Mohd Mahdee, Nurazlin Binti Mohd Fauzi

International Journal of Management, Finance and Accounting

Digital marketing shapes each moment of the contemporary travel journey, yet limited evidence still obscures how individual tactics foster purchase decisions. This conceptual study will develop an integrative framework that integrates four core touch-points, including social media marketing, email marketing, search engine marketing, and online reviews on travellers’ purchase intentions, positing brand trust as the central psychological mechanism. Guided by the Stimulus-Organism-Response theory, thirteen propositions will specify both the direct effects of each touch-point on trust and purchase intention, and trust as a mediator role. To demonstrate the mechanism for empirical validation, future research will conduct a purposive sampling of …

Artificial Intelligence And Employee Well-Being: A Systematic Literature Review, Dombagaha Pathiranage Marian Shavini Medonka Peiris

International Journal of Management, Finance and Accounting

Artificial Intelligence (AI) is transforming modern workplaces by offering opportunities to enhance employee well-being while simultaneously introducing significant challenges. Although scholarly interest in the intersection of AI and well-being is growing, empirical research in this domain remains limited and underdeveloped. This study's primary objective was to assess the current knowledge in this domain, with a secondary aim of identifying critical research gaps to inform future investigations. Adhering to PRISMA guidelines, this systematic literature review analysed 23 empirical studies published between 2015 and 2025, sourced from the Lens.org and ProQuest databases and was guided by the Job Demands Resources (JD–R) model. …

Advances In Culture, Tourism, And Hospitality Research: Volume 1, Cihan Cobanoglu, Hanqin Qiu, Jiaying Lyu, James H. W. Shen

University of South Florida (USF) M3 Publishing

This is the first volume of the Advances in Culture, Tourism, and Hospitality Research Book Series.

Exploring The Pathways Of Artificial Intelligence And Sustainable Development In The Era Of Industrial Revolutions: A Bibliometric Analysis And Future Research Agenda, Xu Bin, Teh Sin Yin, Sajal Saha

International Journal of Management, Finance and Accounting

Artificial Intelligence (AI) is playing an increasingly pivotal role in driving innovation and promoting sustainable development across various sectors amid the ongoing wave of industrial revolutions. However, the existing research lacks a systematic and quantitative overview of how AI contributes to sustainability goals. This study addresses this gap by conducting a bibliometric analysis of 101 articles from the Web of Science Core Collection, using the keywords “sustainab*”, “artificial intelligence”, and “industrial revolution”. Analytical tools such as VOSviewer and Scimago Graphica were employed to generate keyword co-occurrence maps, publication trends, and research collaboration networks. The results show that scholarly interest in …

Drawing Inspiration From The Magic Of The Unconscious In The Surrealist School, In The Works Of Jamil Jamoudi And The Works Of Aminollah Rezaei: A Comparative Study, Bashar Noumi

Journal of Language, Literature, and Arts

This paper provides a comparative analysis of the embryonic Surrealism of two well-known figures of the era: Jamil Hamoudi, an Iraqi surrealist artist, and Aminullah Rezaei, an Iranian surrealist artist. The results found that Surrealism in Iraq associated itself with cultural identity and sacred symbolism, unveiling Hamoudi as the merger of geometry, calligraphy, and warm colours, towards reshaping the collective unconscious and reformulating Eastern spirituality in a modernist fashion. While Surrealism itself was an American import, Surrealism in Iran was contained within a frame of clinical satire, with Rezaei using hybrid bodies and anatomical distortions within realism and fantasy to …

Desegregating The Community Of Inquiry In Philosophy For/With Children, Maughn Rollins Gregory, Darren Chetty

Department of Educational Foundations Scholarship and Creative Works

This dialogical article examines persistent challenges in engaging racism, colonialism, and white supremacy within the theory and practice of Philosophy for/with Children (P4/wC). Framed as a mutual interview between two long-standing colleagues, the dialogue revisits formative encounters in the P4/wC community and situates them within broader intellectual traditions, including American pragmatism, deliberative democracy, and Africana philosophy. Drawing on personal experience, archival material, and critical scholarship, the authors interrogate the metaphilosophical assumptions underpinning the “community of inquiry,” particularly its commitments to reasonableness, consensus, and democratic dialogue. Concepts such as the “gated community of inquiry,” white ignorance, nonideal theory, and insurrectionist ethics …

Association Between Tinnitus And Angina Pectoris In U.S. Adults: Evidence From Nhanes 2009–2018, Mitra Britton, Ishan Sunilkumar Bhatt

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Background/Objectives: Tinnitus has been increasingly associated with cardiovascular disease, and recent phenome-wide analyses have identified angina pectoris as a condition linked to tinnitus. This study aimed to replicate and quantify the association between tinnitus and angina pectoris in a nationally representative U.S. adult sample using NHANES, while adjusting for key demographic, cardiovascular, and tinnitus-related risk factors. Methods: Using data from four NHANES cycles 2009–2018, a cross-sectional analysis was conducted, which included 9185 participants, and used multivariate logistic regression analyses to investigate the association between tinnitus and angina pectoris. Results: Among 9185 adults, angina was associated with higher odds of tinnitus …

Single-Valued, Double-Valued, Triple-Valued, Quadruple-Valued, And Quintuple-Valued Neutrosophic Graph, Takaaki Fujita, Arif Mehmood, Arkan A. Ghaib

Neutrosophic Systems with Applications

Concepts such as fuzzy sets, neutrosophic sets, rough sets, and plithogenic sets have been extensively studied as formal tools for modeling uncertainty, and they have found broad applications across many disciplines. A Double-Valued Neutrosophic Set (DVNS) extends the classical neutrosophic framework by splitting indeterminacy into two distinct components: one leaning toward truth and the other leaning toward falsity. In recent years, further refinements—namely Triple-Valued, Quadruple-Valued, and Quintuple-Valued Neutrosophic Sets—have also been introduced and investigated. These uncertainty models have naturally been lifted to graph-theoretic settings, where vertices and edges represent entities and relationships under ambiguity. Although fuzzy graphs and neutrosophic graphs …

Aav Gene Therapy For Mps Iva With Induction Of Immune Tolerance Via Oral Administration Of Epitope Peptides Of N-Acetylgalactosamine-6-Sulfate Sulfatase, Sampurna Saikia, Yasuhiko Ago, Fnu Nidhi, Shaukat Khan, Zhengyu Ma, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Mucopolysaccharidosis IVA (MPS IVA) is caused by the accumulation of undegraded glycosaminoglycans due to the deficiency of the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme. MPS IVA manifests as progressive systemic skeletal dysplasia. Gene therapy (GT) is potentially a one-time treatment in which the enzyme is continuously produced, circulated, and delivered to target tissues. However, immune responses to gene products can diminish therapeutic efficacy. We hypothesized that oral delivery of tolerogenic peptides induces immune tolerance to human GALNS (hGALNS) in MPS IVA mice, enhancing therapeutic efficacy. Neonatal mice deficient in mouse GALNS (mGALNS) were treated orally with three T-cell/B-cell epitope peptides or hGALNS …

Experiments Towards A Neutron Target For Measurements In Inverse Kinematics, S. F. Dellmann, Caroline M. Harrington, O. R. Cantrell, A. L. Cooper, A. Couture, D, V, Gorelov, I Knapová, S. M. Mosby, R. Reifarth, A. Alvarez, A. Aprahamian, J. Butz, I. J. Bos, Michael T. Febbraro, T. Hankins, B. M. Harvey, T. Heftrich, M. Le, Juan J. Manfredi, A. B. Mcintosh, K. V. Manukyan, M. Matney, S. Regener, D. Robertson, A. Simon, D. Sokolovic, E. Stech, G. Tabacaru, W. Tan, M. Wiescher, S. Yennello

Faculty Publications

Neutron-induced reactions play an important role in fundamental nuclear physics, nuclear astrophysics, and applications. In the case of reactions on rare isotopes, there are limited options for direct experimental measurements. The Neutron Target Demonstrator project at Los Alamos National Laboratory seeks to test the feasibility of moderating spallation neutrons within a 1 m³graphite cube to create a standing neutron target for neutron-induced reaction measurements in inverse kinematics. This paper presents the results of experimental neutron flux distribution tests using neutron sources (ranging from 1 keV to 50 MeV) created by accelerators at the University of Notre Dame and …

Alpha And Beta Emitters In Translational Nuclear Medicine: Clinical Advances, Challenges, And Future Direction, Hanieh Karimi, Thomas H. Shaffer, Erik Stauff, Vinay V. R. Kandula, Heidi H. Kecskemethy, Lauren W. Averill, Xuyi Yue

Department of Radiology Faculty Papers

Radiopharmaceutical therapy (RPT) has emerged as a transformative modality in oncology, particularly for patients with metastatic or inoperable tumors. By leveraging molecularly targeted carriers conjugated to cytotoxic radionuclides, RPT enables precise delivery of ionizing radiation to tumor sites while minimizing off-target effects. Central to this approach are alpha (α) and beta (β) particle-emitting radionuclides. This review aims to provide a comprehensive overview of all clinically relevant alpha and beta emitters and incorporates the most recent advances from 2017-2025, offering a comprehensive and up-to-date perspective. Alpha and beta emitters hold significant promises for the future, especially in nuclear medicine, energy, and …