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Articles 31681 - 31710 of 1824646
Full-Text Articles in Entire DC Network
Inheriting The Mess: How Cercla Successor Liability Shapes The Landscape For Asset Purchase Deals, Liam N. Hudson
Inheriting The Mess: How Cercla Successor Liability Shapes The Landscape For Asset Purchase Deals, Liam N. Hudson
Villanova Environmental Law Journal (1991 - )
No abstract provided.
Characterization Of Hyperoxia-Induced Lung Injury In Adult Female Rats, Abraham G. Taye
Characterization Of Hyperoxia-Induced Lung Injury In Adult Female Rats, Abraham G. Taye
Master's Theses (2009 -)
Acute Respiratory Distress Syndrome (ARDS) is a life-threatening lung disease that results from direct or indirect insults to the lung, leading to air-blood barrier damage, pulmonary edema, hypoxemia, and multi-organ failure. Hyperoxia, or exposure to high fractions of oxygen, is used as a life-saving therapy to improve blood oxygenation in patients with ARDS. However, it can also worsen lung injury by inducing excessive production of reactive oxygen species (ROS), primarily from mitochondria, and by contributing to the progression of ARDS. Rat exposure to hyperoxia is a well-established animal model of clinical ARDS that replicates key clinical features. Clinical and preclinical …
A Survey-Based Exploratory Study Of Factors Influencing Women's Intentions To Utilise Pre-Exposure Prophylaxis In The Eastern Cape Province, South Africa: Sociodemographic Characteristics, Hiv Risk Behaviours And Transactional Sex, Rosemary Kalenga, Gary Sharp, Anne M. Teitelman, Monde Makiwane, Larry D. Icard, John B. Jemmott
A Survey-Based Exploratory Study Of Factors Influencing Women's Intentions To Utilise Pre-Exposure Prophylaxis In The Eastern Cape Province, South Africa: Sociodemographic Characteristics, Hiv Risk Behaviours And Transactional Sex, Rosemary Kalenga, Gary Sharp, Anne M. Teitelman, Monde Makiwane, Larry D. Icard, John B. Jemmott
College of Nursing Faculty Papers & Presentations
BACKGROUND: South Africa has the third-highest adult prevalence rate globally, with women comprising 64% of cases. Despite the accessibility of pre-exposure prophylaxis (PrEP), its adoption among women, particularly young women, remains alarmingly low.
OBJECTIVES: The objective of this initial investigation is to explore factors influencing the intentions of South African women to use PrEP, focusing on sociodemographic factors, HIV sexual risk behaviours and involvement in transactional sex.
DESIGN: The research utilised an exploratory design employing surveys.
METHODS: Surveys were conducted in 2015 with 64 women aged 19-49 residing in the Eastern Cape Province of South Africa. The data were analysed …
Cover And Contents
Turkish Journal of Electrical Engineering and Computer Sciences
No abstract provided.
A Joint Optimization-Based Novel Attack For Genomic Beacon Reconstruction, Kousar Saleem, Si̇nem Sav
A Joint Optimization-Based Novel Attack For Genomic Beacon Reconstruction, Kousar Saleem, Si̇nem Sav
Turkish Journal of Electrical Engineering and Computer Sciences
Genomic data sharing has become an essential component of biomedical research, enabling large-scale collaborations and accelerating discoveries in human genetics. To balance the need for accessibility with privacy concerns, several controlled-access mechanisms have been proposed, including genomic beacons. Genomic beacons answer simple presence/absence queries about specific genetic variants. However, prior work has demonstrated that beacons remain vulnerable to genome reconstruction attacks, where an adversary can recover large portions of participants’ genomes using summary statistics. Building on insights from prior reconstruction attacks, we introduce an approach that unifies SNP correlation and allele frequency alignment objectives within a single-stage joint optimization framework. …
Automated Software Size Measurement Using Multilingual Domain-Adapted Language Models, Samet Tenekeci̇, Hüseyi̇n Ünlü, Burak Keçeci̇, Muhammed Efe İnci̇r, Onur Demi̇rörs
Automated Software Size Measurement Using Multilingual Domain-Adapted Language Models, Samet Tenekeci̇, Hüseyi̇n Ünlü, Burak Keçeci̇, Muhammed Efe İnci̇r, Onur Demi̇rörs
Turkish Journal of Electrical Engineering and Computer Sciences
Software Size Measurement (SSM) is crucial for estimating required project effort as well as budget and schedule. However, many small and medium-sized companies struggle to apply objective SSM due to limited resources and lack of expertise. This often leads to inaccurate estimates and project overruns. There is a need for practical, low-resource solutions that support these tasks without requiring expert involvement. Motivated by this challenge, this study proposes an automated software size measurement approach that formulates the measurement task as supervised regression over natural language requirements, using domain-adapted transformer models. We construct large-scale Turkish and English software engineering corpora to …
School-Based Human Service Professionals’ Perceptions Of The Relationships Between Black Families And Southern Schools, Vanessa Faye Barnhill
School-Based Human Service Professionals’ Perceptions Of The Relationships Between Black Families And Southern Schools, Vanessa Faye Barnhill
Walden Dissertations and Doctoral Studies
The experiences that Black parents had in school have been found to influence how they view and interact with schools and the challenges and barriers related to their child’s education attainment. It is important to understand school-based human service professionals’ perceptions about the relationship that Black families have with Southern schools and suggestions these professionals have about promoting better communication and understanding with Black families. The purpose of this qualitative generic study was to examine school human service professionals’ perceptions about the relationship that Black families have with schools and to gather suggestions about how they could promote communication and …
Relationships Between Resource Utilization And Relapse In Rural Areas, Shane Sneddon
Relationships Between Resource Utilization And Relapse In Rural Areas, Shane Sneddon
Walden Dissertations and Doctoral Studies
In the United States, over 100,000 deaths were attributed to drug overdose in 2021. Relapse rates are higher in rural communities than in urban communities due to sociocultural barriers such as employment, limited entrainment activities, and peer pressure during social events. Previous research did not indicate whether the increase or decrease of Daily Living Assessment (DLA-20) scores have a correlation between community resource utilization and relapse. Using systems theory as the research lens, this study examined the correlation between use of community engagement resources and relapse as manifested by scores on the DLA-20. Data were collected from 100 individuals enrolled …
Achieving High Terminal Performance: A Case Study Of Korean Steel Terminals Using Fsqca, Hae Chan Lee, Saeyeon Roh, Inhyeok Yeo, Jinwoong Yoo
Achieving High Terminal Performance: A Case Study Of Korean Steel Terminals Using Fsqca, Hae Chan Lee, Saeyeon Roh, Inhyeok Yeo, Jinwoong Yoo
Plymouth Business School
Steel-dedicated terminals play a critical role in the facilitation of the Korean steel industry. Due to the nature of steel production and handling, Korean steel-dedicated terminals are heavily utilized in the transportation of steel products both domestically and internationally. Despite the importance of steel terminals, there is limited research exploring factors that drive high terminal performance for bulk terminals, let alone steel terminals. Thus, this study examines factors that lead to high terminal performance for Korean steel terminals. A configurational approach was taken using fuzzy-set Qualitative Comparative Analysis (fsQCA) to yield different combinations of factors that drive high terminal performance. …
Pinocchio And The Tiny Pink Monkey (2026) | Coloring Sheet, Jacksonville State University
Pinocchio And The Tiny Pink Monkey (2026) | Coloring Sheet, Jacksonville State University
Department of Theatre & Film Performance Archive
Performed: 13-16 March 2026; "Pinocchio and the Tiny Pink Monkey" was written by Michael Boynton and the Members of the Flying Blink Theatre Ensemble. Artistic team were Carolyn Conover (director), Brayden Turner (stage manager), Addie Barnes and Ophelia Lazo (assistant stage managers), Eli Sims (assistant stage manager/tour manager), Corrine Todd (costume designer), Skye Strauss (puppet designer), Cheyenne Oliver (lighting designer), Ryan Godfrey (assistant lighting designer), Mike Long (fight choreographer). Production staff were Cheyenne Oliver (technical director), Ryan Godfrey (run crew), Akira Scott-Crough (light board operator), Liesl Cristy (spotlight operator), Ellie Boozer (costume shop manager), Molly Willingham (wardrobe head), Devin Knight …
Pinocchio And The Tiny Pink Monkey (2026) | Craft Sheet, Jacksonville State University
Pinocchio And The Tiny Pink Monkey (2026) | Craft Sheet, Jacksonville State University
Department of Theatre & Film Performance Archive
Performed: 13-16 March 2026; "Pinocchio and the Tiny Pink Monkey" was written by Michael Boynton and the Members of the Flying Blink Theatre Ensemble. Artistic team were Carolyn Conover (director), Brayden Turner (stage manager), Addie Barnes and Ophelia Lazo (assistant stage managers), Eli Sims (assistant stage manager/tour manager), Corrine Todd (costume designer), Skye Strauss (puppet designer), Cheyenne Oliver (lighting designer), Ryan Godfrey (assistant lighting designer), Mike Long (fight choreographer). Production staff were Cheyenne Oliver (technical director), Ryan Godfrey (run crew), Akira Scott-Crough (light board operator), Liesl Cristy (spotlight operator), Ellie Boozer (costume shop manager), Molly Willingham (wardrobe head), Devin Knight …
Pinocchio And The Tiny Pink Monkey (2026) | Program, Jacksonville State University
Pinocchio And The Tiny Pink Monkey (2026) | Program, Jacksonville State University
Department of Theatre & Film Performance Archive
Performed: 13-16 March 2026; "Pinocchio and the Tiny Pink Monkey" was written by Michael Boynton and the Members of the Flying Blink Theatre Ensemble. Artistic team were Carolyn Conover (director), Brayden Turner (stage manager), Addie Barnes and Ophelia Lazo (assistant stage managers), Eli Sims (assistant stage manager/tour manager), Corrine Todd (costume designer), Skye Strauss (puppet designer), Cheyenne Oliver (lighting designer), Ryan Godfrey (assistant lighting designer), Mike Long (fight choreographer). Production staff were Cheyenne Oliver (technical director), Ryan Godfrey (run crew), Akira Scott-Crough (light board operator), Liesl Cristy (spotlight operator), Ellie Boozer (costume shop manager), Molly Willingham (wardrobe head), Devin Knight …
Pinocchio And The Tiny Pink Monkey (2026) | Poster, Jacksonville State University
Pinocchio And The Tiny Pink Monkey (2026) | Poster, Jacksonville State University
Department of Theatre & Film Performance Archive
Performed: 13-16 March 2026; "Pinocchio and the Tiny Pink Monkey" was written by Michael Boynton and the Members of the Flying Blink Theatre Ensemble. Artistic team were Carolyn Conover (director), Brayden Turner (stage manager), Addie Barnes and Ophelia Lazo (assistant stage managers), Eli Sims (assistant stage manager/tour manager), Corrine Todd (costume designer), Skye Strauss (puppet designer), Cheyenne Oliver (lighting designer), Ryan Godfrey (assistant lighting designer), Mike Long (fight choreographer). Production staff were Cheyenne Oliver (technical director), Ryan Godfrey (run crew), Akira Scott-Crough (light board operator), Liesl Cristy (spotlight operator), Ellie Boozer (costume shop manager), Molly Willingham (wardrobe head), Devin Knight …
Pinocchio And The Tiny Pink Monkey (2026) | Game Sheet, Jacksonville State University
Pinocchio And The Tiny Pink Monkey (2026) | Game Sheet, Jacksonville State University
Department of Theatre & Film Performance Archive
Performed: 13-16 March 2026; "Pinocchio and the Tiny Pink Monkey" was written by Michael Boynton and the Members of the Flying Blink Theatre Ensemble. Artistic team were Carolyn Conover (director), Brayden Turner (stage manager), Addie Barnes and Ophelia Lazo (assistant stage managers), Eli Sims (assistant stage manager/tour manager), Corrine Todd (costume designer), Skye Strauss (puppet designer), Cheyenne Oliver (lighting designer), Ryan Godfrey (assistant lighting designer), Mike Long (fight choreographer). Production staff were Cheyenne Oliver (technical director), Ryan Godfrey (run crew), Akira Scott-Crough (light board operator), Liesl Cristy (spotlight operator), Ellie Boozer (costume shop manager), Molly Willingham (wardrobe head), Devin Knight …
Prevalence Of Contact Child Sexual Abuse Victimization In The Us: Perpetration Types And Cohort Differences, Luciana C. Assini-Meytin, Rebecca L. Fix, Yi Sun, David Finkelhor, Elizabeth J. Letourneau, Keith Kaufman, Ben Mathews
Prevalence Of Contact Child Sexual Abuse Victimization In The Us: Perpetration Types And Cohort Differences, Luciana C. Assini-Meytin, Rebecca L. Fix, Yi Sun, David Finkelhor, Elizabeth J. Letourneau, Keith Kaufman, Ben Mathews
Psychology Faculty Publications and Presentations
We investigated the prevalence of contact child sexual abuse (CSA) victimization in the US by comparing perpetration types in two adult cohorts. Participants included a nationally representative sample of adults aged 18–22 (n = 3,174) and 32–36 (n = 3,237). We used weighted proportions to obtain prevalences, Rao-Scott χ2 tests to assess for differences between cohorts. Analyses were also stratified by gender. The overall prevalence was 21.7% and similar between the two cohorts; 9.7% reported abuse by adults and 16.9% by youth under age 18. Most said that offenses were perpetrated by people known to them. CSA perpetration by youth …
Ucc Minutes Mar 13, 2026, Undergraduate Curriculum Council
Ucc Minutes Mar 13, 2026, Undergraduate Curriculum Council
Undergraduate Currirculum Committee Minutes
No abstract provided.
Heterocyclic‐Fused Squaramides: Anionophores With Antimicrobial Activity, Luke Edward Brennan, Chris Samuel Hawes, Kevin Kavanagh, Robert Brian Peter Elmes
Heterocyclic‐Fused Squaramides: Anionophores With Antimicrobial Activity, Luke Edward Brennan, Chris Samuel Hawes, Kevin Kavanagh, Robert Brian Peter Elmes
Research Outputs: 2025-Present
Antimicrobial resistance is regarded as one of the foremost public health risks of the 21st century, highlighting the need for new antimicrobial agents and chemical tools to interrogate their biological activity. Artificial transmembrane anion transporters have emerged as promising supramolecular scaffolds in this context, having demonstrated membrane activity in mammalian systems and showing growing potential in antimicrobial research. Here, we report a series of heterocycle‐fused squaramide anionophores capable of binding and transporting chloride. Several members of this series display measurable antimicrobial activity, alongside evidence of intracellular chloride modulation in bacterial cells. Taken together, these findings indicate that membrane localisation and …
Guiding Fast Ion Beam By Suppressing Secondary Ions, Yingli Xue, Junliang Liu, Mingwu Zhang, Daniel Fischer, Guoxing Xia, Nikolaus Stolterfoht, Reinhold Schuch, Yehong Wu, Bian Yang, Xiaoxiao Li, Caojie Shao, Wei Wang, Zhangyong Song, Xing Fang
Guiding Fast Ion Beam By Suppressing Secondary Ions, Yingli Xue, Junliang Liu, Mingwu Zhang, Daniel Fischer, Guoxing Xia, Nikolaus Stolterfoht, Reinhold Schuch, Yehong Wu, Bian Yang, Xiaoxiao Li, Caojie Shao, Wei Wang, Zhangyong Song, Xing Fang
Physics Faculty Research & Creative Works
We demonstrate that secondary ions sputtered from a macrocapillary's inner surface by the primary beam induce premature saturation of the guiding field, hindering fast ion guiding. By suppressing secondary ion sputtering with grooved surfaces, we achieve a guiding-field potential difference exceeding 1 kV, 2 orders of magnitude larger than previously achieved in stable ion guiding. This enables stable guiding of a 20-keV/q O5+ beam at offset angles up to 15°, with transmitted ions retaining their initial energy and charge state. A self-consistent field model accurately reproduces these results, revealing that guiding performance relies on managing secondary ions and the channel's …
Draft Final Remedial Design Work Plan Blacktail Creek Riparian Actions Butte Priority Soils Operable Unit Of The Silver Bow Creek/Butte Area Superfund Site Silver Bow County, Montana, Hydrogeologic, Inc.
Draft Final Remedial Design Work Plan Blacktail Creek Riparian Actions Butte Priority Soils Operable Unit Of The Silver Bow Creek/Butte Area Superfund Site Silver Bow County, Montana, Hydrogeologic, Inc.
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Human First: How Journalists Employ Ethics Of Care And Empathy When Covering School Shootings, Grace M. Ficara
Human First: How Journalists Employ Ethics Of Care And Empathy When Covering School Shootings, Grace M. Ficara
USF Tampa Graduate Theses and Dissertations
School shootings have become a regular part of the news media cycle in the 21st century. Now, more than ever, journalists are needing to find innovative, yet empathetic, ways to deal with such crises as they navigate their own professional boundaries. Using the Ethics of Care model, this research intends to showcase how journalists have, willingly or unwillingly, utilized an empathetic approach when covering school shootings and how they use these tools to comfort their sources and themselves. Through semi - structured interviews of 9 participants, this study seeks to connect the practice of journalism with the one thing journalists …
Spin Pumping And Interfacial Anisotropy In Ultrathin Cobalt Heterostructures, Ibrahim Almuhanna
Spin Pumping And Interfacial Anisotropy In Ultrathin Cobalt Heterostructures, Ibrahim Almuhanna
USF Tampa Graduate Theses and Dissertations
Interfaces dominate the behavior of ultrathin ferromagnets, where interfacial spin-orbit coupling(SOC) can strongly influence both magnetic anisotropy and magnetization dynamics. This thesis compares how a heavy-metal interface (Pt) and a semiconducting two-dimensional transition-metal dichalcogenide (TMD) interface (MoSe2) modify the static and dynamic magnetic properties of ultrathin Co. To isolate interface-driven effects, the heterostructure architecture is kept fixed (sapphire substrate and Si3N4 cap) while only the seeding/interface layer beneath Co is varied. MoSe2 is studied in two thickness conditions (monolayer and bilayer) to test layer-dependent trends.
Layer thicknesses are determined by X-ray reflectivity. Static magnetic properties are measured by in-plane vibrating …
A Look At The Potential Impacts Of Priming Thoughts Through The Show Family Guy, Thomas Wiskoff
A Look At The Potential Impacts Of Priming Thoughts Through The Show Family Guy, Thomas Wiskoff
USF Tampa Graduate Theses and Dissertations
This study examined whether brief exposure to a death-themed episode of the adult animated show Family Guy could prime viewers to adopt less serious attitudes toward death and dying. Drawing primarily from priming theory, with supporting insights from cultivation and framing theories, the research focused on the show's unique use of magical realism and irreverent humor, particularly the personification of Death as the sarcastic Grim Reaper, to explore potential shifts in death-related attitudes. Participants (N = 100) were randomly assigned to view one of two clips from Family Guy Season 2, Episode 6 ("Death is a Bitch") with one clip …
Examining The Effect Of Household Socioeconomic Status And Maternal Characteristics On Child Developmental Delay In The United States, Samuel Ilori
USF Tampa Graduate Theses and Dissertations
Child developmental delay remains a pressing public health issue with lifelong implications. This study examines the association between household socioeconomic status, maternal characteristics, and child developmental delay using data from the 2023 National Survey of Children's Health (N = 35,399 female respondents). Bivariate analyses using Chi-square tests and binary logistic regression with sequential modeling were conducted. Results revealed that economic hardship, employment status, maternal mental health, maternal physical health, marital status, and race were significantly associated with child developmental delay (p<0.001). Educational level and poverty level showed no significant associations. Among mothers reporting poor mental health, 90.0% had a child with a delay, compared to 6.6% among those with good mental health. Every mother reporting poor physical health had a child with a delay, while virtually none with good or better physical health did. In the fully adjusted regression model, maternal mental and physical health remained the most powerful predictors, while economic hardship and employment status became non-significant once health was introduced, suggesting mediation. Maternal mental and physical health are the factors most strongly correlated with child developmental delay. Economic hardship matters primarily because it undermines maternal well-being. The COVID-19 pandemic likely intensified these dynamics by disrupting healthcare access and increasing economic instability. Supporting maternal health must be recognized as a fundamental strategy for promoting child development. Universal screening for maternal depression and physical health problems, integrated into pediatric and obstetric care, can identify at-risk mothers early. Policies that reduce economic hardship alleviate the chronic stress that undermines maternal health. Children thrive when their mothers are healthy.
Draft Final Phase I Pre-Design Investigation Evaluation Report Blacktail Creek Riparian Actions Butte Priority Soils Operable Unit Of The Silver Bow Creek/Butte Area Superfund Site Silver Bow County, Montana, Hydrogeologic, Inc.
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Emotional And Psychological Well-Being In Early Postmenopausal Women: A Phenomenological Study, Marjorie F. Leon
Emotional And Psychological Well-Being In Early Postmenopausal Women: A Phenomenological Study, Marjorie F. Leon
Walden Dissertations and Doctoral Studies
The purpose of this qualitative phenomenological study was to explore how early postmenopausal women experience and navigate emotional and psychological well-being during the postmenopausal transition. Although menopause has been widely examined as a biological process, women’s lived emotional and psychosocial experiences during the early postmenopausal period remain underexplored in psychological research. Conceptually informed by Engel’s biopsychosocial model, this study examined how biological, psychological, and social factors intersect in shaping resilience, identity, and coping during this transitional life stage. Thirteen women within 5 years of menopause onset participated in semi structured interviews. Data were analyzed using Braun and Clarke’s six-phase reflexive …
Layer-Wise Printing Parameter Optimization For Laser Powder Bed Fusion, Chaoran Dou, Rongxuan Wang, Raghav Gnanasambandam, Jianzhi Li, Zhenyu James Kong
Layer-Wise Printing Parameter Optimization For Laser Powder Bed Fusion, Chaoran Dou, Rongxuan Wang, Raghav Gnanasambandam, Jianzhi Li, Zhenyu James Kong
Manufacturing & Industrial Engineering Faculty Publications
Additive manufacturing (AM) is a transformative technology that enables the fabrication of complex geometries layer by layer. However, metal parts produced via AM processes such as laser powder bed fusion (LPBF) are prone to various defects, including porosity and deformation. These defects often result from suboptimal printing parameter settings. Traditional approaches typically aim to reduce defects by optimizing a fixed set of parameters for the entire part. However, such methods do not account for layer-wise variations in printing conditions caused by changes in geometry, heat transfer, and re-heating effects. While optimizing parameters for each layer could improve part quality, it …
Potential And Chloride Concentration As Thresholds For Crevice Corrosion Initiation In Ss 316l, Y Shorrab, R S. Lillard
Potential And Chloride Concentration As Thresholds For Crevice Corrosion Initiation In Ss 316l, Y Shorrab, R S. Lillard
University Research
This work investigated the relationship between crevice chloride concentration ([Cl−]) and the potential necessary for initiation in stainless steel 316L (SS 316L). Real-time fluorescence measurements were used to measure [Cl−] inside SS 316L crevice assemblies as a function of bulk [Cl−] and potential. Crevice initiation at potentials slightly less than or equal to the bulk repassivation potential was associated with chloride transport, owing to passive dissolution, and an increase in the crevice [Cl−]. Once the [Cl−] within the crevice increased to the concentration necessary to initiate SS 316L pitting at the applied potential, crevice corrosion was initiated. For example, in …
Cannabis Stigma And Symptom Management Considerations In Cancer Survivors: A Mixed-Methods Exploration Of Patient Perspectives, Sera Levy, Salimah Meghani, Brooke Worster, Colleen Kilanowski, Danielle Smith, Amy A. Case, Rebecca L. Ashare
Cannabis Stigma And Symptom Management Considerations In Cancer Survivors: A Mixed-Methods Exploration Of Patient Perspectives, Sera Levy, Salimah Meghani, Brooke Worster, Colleen Kilanowski, Danielle Smith, Amy A. Case, Rebecca L. Ashare
Department of Medical Oncology Faculty Papers
PURPOSE: This study aims to assess for indications of stigma and attitudes toward cannabis among cancer survivors (CS) who use or consider the use of cannabis.
METHODS: This study employed a convergent, parallel mixed methods design utilizing focus group and questionnaire data to assess the presence of stigma among a sample of CS (n = 23) who use (n = 10) and do not use (n = 13) cannabis to manage symptoms. CS were recruited from a multi-site observational study in the Northeast U.S. region that assesses cannabis use among oncology patients.
RESULTS: A total of 23 CS participated in …
Ionic Liquid Pilocarpine Serves As Therapeutic Cosolvent And Permeation Enhancer For Glaucoma Medication, Ashish Trital, Lei Xu, Burhan Ates, Tzu Chen Wang, Vimalin Mani, Hu Yang
Ionic Liquid Pilocarpine Serves As Therapeutic Cosolvent And Permeation Enhancer For Glaucoma Medication, Ashish Trital, Lei Xu, Burhan Ates, Tzu Chen Wang, Vimalin Mani, Hu Yang
Chemical and Biochemical Engineering Faculty Research & Creative Works
The efficacy of hydrophobic ocular drugs is significantly hindered by their low bioavailability, for which poor water solubility is a major contributing factor. In this work, we synthesized pilocarpine-derived ionic liquid [Pilo-OEG] Cl (PO) and evaluated its cosolvent properties for the codelivery of the hydrophobic antiglaucoma drug brimonidine (BM) for glaucoma therapy. Pilocarpine was quaternized with 2-[2-(2-chloroethoxy) ethoxy] ethanol in a one-pot reaction to yield PO, and its structure was confirmed using 1H NMR and FT-IR spectroscopy methods and further characterized for its rheological property and thermal stability. The HET-CAM assay and cell viability study showed that PO was …
Gadolinium Nanoparticles: Emerging Platforms Beyond Imaging For Drug Delivery And Theranostics, Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer, Heyam Zayed, Paris Marabut, Keykavous Parang
Gadolinium Nanoparticles: Emerging Platforms Beyond Imaging For Drug Delivery And Theranostics, Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer, Heyam Zayed, Paris Marabut, Keykavous Parang
Pharmacy Faculty Articles and Research
Gadolinium nanoparticles (GdNPs) have gained increasing attention as multifunctional metal-based nanoplatforms that extend far beyond their traditional use as magnetic resonance imaging (MRI) contrast agents. Their specific magnetic properties, tunable physicochemical features, and tunable biocompatibilities with biocompatible coatings give them great potential as drug delivery and theranostic applications. They offer greater stability, lower systemic toxicity, and more surface modification options compared to molecular gadolinium chelates. The functionalized GdNPs not only show excellent properties as drug carriers for their specific indications but also serve as agents in various imaging modalities with superior therapeutic efficacy by means of radio sensitization and magnetically …