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Approaching Quantum-Limited Electrometry In The Single-Photon Regime, Sisira Kanhirathingal May 2022

Approaching Quantum-Limited Electrometry In The Single-Photon Regime, Sisira Kanhirathingal

Dartmouth College Ph.D Dissertations

Mesoscopic quantum systems currently serve as essential building blocks in many quantum information and metrology devices. This thesis investigates the potential of quantum-limited detection in a mesoscopic electrometer named the cavity-embedded Cooper pair transistor (cCPT). As one application, this charge detector can act as the basis for an optomechanical system in the single-photon strong coupling regime. The realization of this scheme would entail near quantum-limited, ultra-sensitive electrometry at the single-photon level, the feasibility of which is studied at length in this thesis.

On the one hand, we approach this question using a fundamental, first-principles study, where an operator scattering model …


Statutory Provisions Governing Special Education: A Guide For Beginning Special Education Teachers, Hannah Sagvold May 2022

Statutory Provisions Governing Special Education: A Guide For Beginning Special Education Teachers, Hannah Sagvold

Dissertations, Theses, and Projects

Special education law is complex and ever-changing. Despite receiving a formal education, beginning special education teachers often lack the knowledge of these policies and procedures, as well as any updated provisions relating to these laws (Brookshire & Klotz, 2002). In order to provide a legally compliant education to all students, teachers must be held accountable for the proper implementation of these laws (Sanders, 2011). Current research suggests that a large majority of teachers overestimate their knowledge of special education law, when in reality, a significant knowledge gap exists (Sanders, 2011 & Horner, Mrachko, O’Connor & Yasik, 2020). It is imperative …


Biometal Distribution And Diffusion: Contrast Resolution By Low Energy Mammography Versus High Spatial Resolution By Computed Tomography, Guito Charles, Robert O’Brien, Areeba Masroor May 2022

Biometal Distribution And Diffusion: Contrast Resolution By Low Energy Mammography Versus High Spatial Resolution By Computed Tomography, Guito Charles, Robert O’Brien, Areeba Masroor

Publications and Research

Low energy X-rays from a Mammography system were used to capture small differences in inherent tissue contrast in two-dimensional images of cut samples of select fruit and vegetable models avoiding excessive volume averaging. High spatial resolution CT images were also acquired of whole fruits to avoid volume averaging to help detect low tissue contrast. A limitation of CT imaging is the high kVp unavoidable in CT that lowers tissue contrast while the advantages are that of non-invasive 3D visualization. Using these two approaches that are very different in physical principles it is not known if either one could display possible …


The Living Breakwaters Pdr Efforts: Conceptual Scheduling, Calvin O. Walters Jr. May 2022

The Living Breakwaters Pdr Efforts: Conceptual Scheduling, Calvin O. Walters Jr.

Publications and Research

On October 29, 2012, Superstorm Sandy caused nearly $19 billion in damages in New York City including 69,000 residential units across the five boroughs. This disaster precipitated a post-disaster-rebuilding (PDR) project including roughly $4.2 billion in a Community Development Block Grant allocated towards PDR projects. A portion of the grant was used to construct a living breakwater in Tottenville, Staten Island, consisting of a resiliency approach to risk reduction through erosion prevention, wave energy attenuation, and enhancement of ecosystems and social resiliency to improve resistance to storms for the community of Tottenville. The ridges of each breakwater are designed with …


Exploring Solidworks Simulation And Structural Analysis Tools To Predict Real-World Physical Behaviors, Itay Rubin May 2022

Exploring Solidworks Simulation And Structural Analysis Tools To Predict Real-World Physical Behaviors, Itay Rubin

Publications and Research

Computer Aided Design (CAD) Software can optimize the product design process prior to manufacturing. This project examines engineering solutions using CAD software called SolidWorks. It simulates how the product will behave under a variety of engineering constraints. These simulations allow designers to optimize performance, cost, and speed efficiencies. The project uses simulations and finite element analysis to replicate real world behavior. It presents high-level capabilities in the design process, exposing new engineers to simulation tools that are available and relevant in mechanical engineering design. This project required independent research to obtain an advanced understanding of the software interface and capabilities.


Lake Satellite Temperature Data Validation, Mamadou Balde, Pascal Kouogang May 2022

Lake Satellite Temperature Data Validation, Mamadou Balde, Pascal Kouogang

Publications and Research

In environmental remote sensing, satellite data isn't absolutely conclusive, for that reason, there is a natural need to verify the data acquired from the satellite. The most suitable tool to achieve such verification is on ground sensors that have the advantage of proximity. Addressing any possible discrepancies between the satellite data and the ground sensor data is sure to yield ways to come up with improvements of satellite band calibration and sensing capabilities. This research focused on correlating temperature data from the MODIS satellite with the data obtained from the In Situ sensor located in Lake Sunapee. Doing the latter …


Calkas’S Daughter: Paternal Authority And Feminine Virtue In Troilus And Criseyde, Jennifer Alberghini May 2022

Calkas’S Daughter: Paternal Authority And Feminine Virtue In Troilus And Criseyde, Jennifer Alberghini

Medieval Feminist Forum: A Journal of Gender and Sexuality

The heroine of Geoffrey Chaucer’s Troilus and Criseyde has been of considerable interest to medieval feminist scholars as a woman who is depicted as both virtuous and an adulteress. Yet critical discussions do not often view Criseyde’s virtue in light of her role as daughter. This article explores that role, focusing on how her father Calkas is described by the characters as having authority over his daughter’s body in the marriage market. This will later enable them to use him as an excuse for Criseyde’s failure to return to Troy and thus preserve her status as virtuous. However, the characters …


Medieval Feminist Forum: A Journal Of Gender And Sexuality 57.2 (2022) May 2022

Medieval Feminist Forum: A Journal Of Gender And Sexuality 57.2 (2022)

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.


Affect And The Tomb In Robert Henryson's Testament Of Cresseid, Elizabeth Elliott May 2022

Affect And The Tomb In Robert Henryson's Testament Of Cresseid, Elizabeth Elliott

Medieval Feminist Forum: A Journal of Gender and Sexuality

The penultimate verse of Henryson’s Testament of Cresseid suggests the possibility that Troilus raised a monument in memory of his former love, Cresseid: “Sum said he maid ane tomb of merbell gray” (l. 603). Examining the political implications of this uncertain act of memorialisation, this article considers how Henryson's poem mobilises the reader's emotional response to constitute Cresseid as a mourned subject, whose subjectivity is recognised only insofar as it is limited to suffering and death. In doing so, the Testament also establishes a subjectivity for women that offers conditional tolerance predicated on respectable behaviour, contributing to the historical production …


John Crophill: A Trustworthy Man In Fifteenth-Century Rural England (Gms Essay Prize Article), Rehan Shah May 2022

John Crophill: A Trustworthy Man In Fifteenth-Century Rural England (Gms Essay Prize Article), Rehan Shah

Medieval Feminist Forum: A Journal of Gender and Sexuality

This paper explores the role of trust and trustworthiness in the masculine gender identity of the fifteenth-century bailiff and medical practitioner John Crophill (d. c. 1485) who resided in Wix, Essex. Drawing on evidence from his personal notebook, the work argues that Crophill was aware of the need to construct his trustworthy reputation, a requirement enacted via his own interaction with other individuals. A consideration of three separate elements of his persona (party host, craft master, and probable involvement with childbirth) provide a structure for the paper, as Crophill seemingly negotiates his own relationships with both male and female individuals, …


Whose Middle Ages? Teachable Moments For An Ill-Used Past, Ana C. Núñez May 2022

Whose Middle Ages? Teachable Moments For An Ill-Used Past, Ana C. Núñez

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.


This Is My Body: Eucharistic Theology And Anthropology In The Writings Of Gertrude The Great Of Helfta, Jessica Barr May 2022

This Is My Body: Eucharistic Theology And Anthropology In The Writings Of Gertrude The Great Of Helfta, Jessica Barr

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.


Assessing The Influences On Rural Women's Reproductive Life Plans: A Cross-Sectional Descriptive Study, Lori M. Jagoda May 2022

Assessing The Influences On Rural Women's Reproductive Life Plans: A Cross-Sectional Descriptive Study, Lori M. Jagoda

Theses

Rural women's unique personal, social, cultural, and economic characteristics influence their health care decision-making processes. To assess the influences on rural women and their Reproductive Life Plans, a cross-sectional descriptive study, based on the Health Promotion Model (HPM), was used.


Racial Disparity In Health Insurance Acquisition In The State Of California, Florence Jill Polina May 2022

Racial Disparity In Health Insurance Acquisition In The State Of California, Florence Jill Polina

Theses

Racial disparity continues to be a struggle in America. The main purpose of this project was to determine whether there is a relationship between race and the acquisition of health insurance in adult residents of California who are younger than 65 years old. Through secondary data gathering, analysis of an existing racial disparity in health care insurance acquisition was accomplished. The results of the project indicate that a relationship exists between race and health insurance acquisition, thereby promoting an opportunity to determine hindering factors and discuss recommendations that can help to alleviate them.


The Role Of University Libraries In Accreditation Of Academic Programmes: Challenges And Prospects, Flora Ifeoma Okogwu, Juliana Obiageri Akidi May 2022

The Role Of University Libraries In Accreditation Of Academic Programmes: Challenges And Prospects, Flora Ifeoma Okogwu, Juliana Obiageri Akidi

Library Philosophy and Practice (e-journal)

The National Universities Commission, the supervisory body of all Universities in Nigeria assesses the universities for standards and quality assurance of programmes on regular basis. The paper examined how accreditations are carried out by the National Universities Commission and the accreditation roles of the university libraries were examined. The study also unveiled the challenges of accreditation in University Libraries which include late notification of forthcoming accreditation, financial constraint, out datedness of information resources, and understaff. The study suggested possible ways out of these challenges which include timely notification of date of accreditation, provision of finance to enable the library acquire …


Early Outpatient Treatment For Covid-19 With Convalescent Plasma., David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Evan M. Bloch, Bryan Lau, Aarthi G. Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie-Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C. Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley May 2022

Early Outpatient Treatment For Covid-19 With Convalescent Plasma., David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Evan M. Bloch, Bryan Lau, Aarthi G. Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie-Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C. Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley

Pathology Research and Scholarship

BACKGROUND: Polyclonal convalescent plasma may be obtained from donors who have recovered from coronavirus disease 2019 (Covid-19). The efficacy of this plasma in preventing serious complications in outpatients with recent-onset Covid-19 is uncertain.

METHODS: In this multicenter, double-blind, randomized, controlled trial, we evaluated the efficacy and safety of Covid-19 convalescent plasma, as compared with control plasma, in symptomatic adults (≥18 years of age) who had tested positive for severe acute respiratory syndrome coronavirus 2, regardless of their risk factors for disease progression or vaccination status. Participants were enrolled within 8 days after symptom onset and received a transfusion within 1 …


An Analysis Of Non-Comparison Based Sorting Algorithms, Jacob M. Gomez, Edgar Aponte, Brad Isaacson May 2022

An Analysis Of Non-Comparison Based Sorting Algorithms, Jacob M. Gomez, Edgar Aponte, Brad Isaacson

Publications and Research

Sorting algorithms put elements of a list into an order (e.g., numerical, alphabetical). Sorting is an important problem because a nontrivial percentage of all computing resources are devoted to sorting all kinds of lists. For our project, we implemented two non-comparison based sorting algorithms from pseudocode and compared them to various comparison based sorting algorithms. The two algorithms have their advantages and disadvantages as well as their unique features. We found that Radix Sort (which is a modified version of Counting Sort) was the most efficient of them all.


Compare How Students Performed And Attendance Before, During, And After Pandemic Waves, Peber Dejesus, Rohini R. Mattan, Ralph Lauren Ocampo May 2022

Compare How Students Performed And Attendance Before, During, And After Pandemic Waves, Peber Dejesus, Rohini R. Mattan, Ralph Lauren Ocampo

Publications and Research

Covid-19 is a global pandemic that affected many people that includes students from all different parts of the world. In this case, the research would focus on the Radiologic Technology and Medical Imaging program students at New York City College of Technology, who must do hands-on learning in order to accomplish the experience required for the degree.

One of the hardest obstacles that radiologic students must go through are the ones that are unable to be online. One example of those required classes would be the Clinical Rotation. It is mandatory for the radiologic student to go to a required …


Sociopolitical Determinants Of Health In The Proposed Rezoning Of Richmond Hill/Ozone Park, Ny, Khemraj J. Persaud May 2022

Sociopolitical Determinants Of Health In The Proposed Rezoning Of Richmond Hill/Ozone Park, Ny, Khemraj J. Persaud

Publications and Research

The community of Richmond Hill/Ozone Park, Queens, NY has been split into multiple zones and has needed rezoning for decades. The area consists of a range of people from different ethnic backgrounds, including Indo-Caribbean, South Asian, and Afro-Caribbean. Racial health disparities persist in this district, such as obesity, diabetes, and hypertension. I conducted research about how ongoing political issues in this community has been affecting the overall health of its residents and what is being done about it.


May 5, 2022, James Madison University May 2022

May 5, 2022, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.


Quagga Mussel And Zebra Mussel, Ann Mull, Lori R. Spears May 2022

Quagga Mussel And Zebra Mussel, Ann Mull, Lori R. Spears

All Current Publications

Quagga mussel and zebra mussel can cause significant ecological, economical, and recreational impacts. This fact sheet describes these two-sided mollusks and reviews impacts, monitoring, and management of these invasive species.


Novel Fold Of Rotavirus Glycan-Binding Domain Predicted By Alphafold2 And Determined By X-Ray Crystallography, Liya Hu, Wilhelm Salmen, Banumathi Sankaran, Yi Lasanajak, David F Smith, Sue E Crawford, Mary K Estes, B V Venkataram Prasad May 2022

Novel Fold Of Rotavirus Glycan-Binding Domain Predicted By Alphafold2 And Determined By X-Ray Crystallography, Liya Hu, Wilhelm Salmen, Banumathi Sankaran, Yi Lasanajak, David F Smith, Sue E Crawford, Mary K Estes, B V Venkataram Prasad

Faculty, Staff and Students Publications

The VP8* domain of spike protein VP4 in group A and C rotaviruses, which cause epidemic gastroenteritis in children, exhibits a conserved galectin-like fold for recognizing glycans during cell entry. In group B rotavirus, which causes significant diarrheal outbreaks in adults, the VP8* domain (VP8*B) surprisingly lacks sequence similarity with VP8* of group A or group C rotavirus. Here, by using the recently developed AlphaFold2 for ab initio structure prediction and validating the predicted model by determining a 1.3-Å crystal structure, we show that VP8*B exhibits a novel fold distinct from the galectin fold. This fold with a β-sheet clasping …


Cardiovascular And Range Of Motion Effects After Exercise Training Interventions, Nolynn E. Sutherland May 2022

Cardiovascular And Range Of Motion Effects After Exercise Training Interventions, Nolynn E. Sutherland

LSU Doctoral Dissertations

The effects of stretching and yoga on the cardiovascular and muscular systems are still being discovered and can be assessed non-invasively. The purpose of this dissertation was to examine the non-invasive markers of stretching and yoga on the metabolic, cardiovascular, and muscular systems. A series of three studies were conducted to gain insight into how stretching and yoga influence the body and if there are any potential differences between them.

The first study aimed to determine if stretching would influence fiber type and motor unit recruitment. An acute bout of stretch exercise was performed immediately before a biking exercise session …


Symposium: Sexual Orientation, Gender Identity & The Constitution: American Constitutions And Artificial Insemination Births, Jeffrey A. Parness May 2022

Symposium: Sexual Orientation, Gender Identity & The Constitution: American Constitutions And Artificial Insemination Births, Jeffrey A. Parness

ConLawNOW

Childcare parentage issues arising from assisted reproduction births are subject to constitutional guidance, including due process, equal protection, and privacy dictates. Constitutional rights, however, sometimes go unrecognized in assisted reproduction laws, particularly for same sex couples, wed and unwed, as well as for single women. Upon a brief review of contemporary American state assisted reproduction laws, current and future constitutional precedents are explored. This analysis shows that constitutional, as well as public policy, reforms are particularly needed for same-sex female couples and single women employing assisted reproduction as intended parents.


Inclusive Approaches For Measuring Demographics Of Underrepresented Populations In Stem And Biomedical Research Training Programs, Stephanie E. Paris, Teala W. Alvord, Brandy Lentz, Mollie C. Marr, Angie Setthavongsack, Alexis Dinno, Jae Downing, Aaron Raz Link, Dawn M. Richardson, Shanthia N. Espinosa, Phuc T. Nguyen, Lisa K. Marriott May 2022

Inclusive Approaches For Measuring Demographics Of Underrepresented Populations In Stem And Biomedical Research Training Programs, Stephanie E. Paris, Teala W. Alvord, Brandy Lentz, Mollie C. Marr, Angie Setthavongsack, Alexis Dinno, Jae Downing, Aaron Raz Link, Dawn M. Richardson, Shanthia N. Espinosa, Phuc T. Nguyen, Lisa K. Marriott

Student Research Symposium

Federal strategic plans call for increased diversity within the biomedical workforce. The National Institutes of Health (NIH) defined underrepresented populations in biomedical science (NOT-OD-20-031), though operationalization remains a challenge for training programs. Implementing inclusive demographic measures may help to identify key demographic groups facing barriers to participation and retention in STEM programs and the biomedical workforce. Approaches for measuring demographic variables were sourced from scientific literature and research stakeholders. Gender, race/ethnicity, disability, and disadvantaged background were prioritized for comparison given their focus by NIH, with opportunities for stakeholders to identify additional demographic variables important in their work. Gender minorities, sex …


Barriers And Supports For Stem Motivation For Pacific Islander High School And Undergraduate Students, Shanthia N. Espinosa, Alma M. O. Trinidad, Lisa K. Marriott May 2022

Barriers And Supports For Stem Motivation For Pacific Islander High School And Undergraduate Students, Shanthia N. Espinosa, Alma M. O. Trinidad, Lisa K. Marriott

Student Research Symposium

Pacific Islander (PI) students disproportionately come from low socioeconomic backgrounds and are often first-generation college students. PI students have been historically underserved with limited access to educational resources and support. As a result, PI students face low student retention rates and have reported dissatisfaction with higher education student services. There is little research dedicated to understanding the STEM experiences of PI students related to access, success, and motivational resilience in higher education. This study examines barriers and facilitating factors for motivation among PI students using electronic surveys, focus groups, and group discussions. Participants comprise high school and undergraduates residing in …


Refractory Herpes Virus Pseudotumor In An Immunocompromised Patient, Pavan Patel, Smera Saikumar, David York May 2022

Refractory Herpes Virus Pseudotumor In An Immunocompromised Patient, Pavan Patel, Smera Saikumar, David York

Research Day

Background: HSV infections can characteristically present as pseudotumor in patients with uncontrolled HIV infection. Herpes simplex virus type 2 (HSV-2) infection rates range from 60% to 90% in individuals who are co-infected with HIV.

Case Presentation: A 48-year-old patient who presented with large fungating mass near her right inferior vulva with hardness and induration. The mass was 4 cm x 3 cm in size and was excised in the operating room. The pathology was negative for malignancy, however, it showed lymphoplasmacytic proliferation with immunostaining positive for HSV virus.

Conclusion: Any patient that presents with a tumor-like mass in their perineum …


A Paraurethral Aggressive (Deep) Angiomyxoma, Smera Saikumar, Pavan Patel, Christian Edwards, Geosette Garcia, Daniel York, Hyder Naqvi May 2022

A Paraurethral Aggressive (Deep) Angiomyxoma, Smera Saikumar, Pavan Patel, Christian Edwards, Geosette Garcia, Daniel York, Hyder Naqvi

Research Day

Background: Aggressive angiomyxomas (AAs) are rare mesenchymal tumors that are histologically composed of myxoid stroma and vasculature. AAs are typically located in the pelvis and perineum and occur more frequently in females of reproductive age. Although a complete resection of the AA is the definitive cure, it is often difficult to achieve due to a lack of capsule in the tumor.

Case Presentation: In this report, we outline a patient who had a paraurethral tumor for eight months before symptoms were observed. The mass measured 3.55 cm x 2.0 cm x 1.5 cm and was excised in the operating room …


Hypersensitivity Pneumonitis: A Clinical Case With Rapid Resolution On Imaging, Jordan Erdfrocht, Max Kabolowsky, Lyndsey Nguyen, Alyson Meyer, Christine Sykalo May 2022

Hypersensitivity Pneumonitis: A Clinical Case With Rapid Resolution On Imaging, Jordan Erdfrocht, Max Kabolowsky, Lyndsey Nguyen, Alyson Meyer, Christine Sykalo

Research Day

Introduction

Hypersensitivity pneumonitis is a rare interstitial disorder characterized by an immune reaction of the lung parenchyma, usually to a sensitized allergen. Pneumonitis is a common cause of respiratory decline among those with comorbid conditions such as chronic obstructive pulmonary disease and congestive heart failure. The use of corticosteroids in patients with pneumonitis is well documented, but their role in the treatment is not clearly understood.

Case Presentation

Patient is a 58-year-old female with past medical history of polymyalgia rheumatica, osteoporosis, and current smoker who presented with a three day history of progressive shortness of breath, dyspnea on exertion, orthopnea, …


A Novel Approach To Triosephosphate Isomerase Deficiency, Kyra Mccarty May 2022

A Novel Approach To Triosephosphate Isomerase Deficiency, Kyra Mccarty

Research Days

Background: Triosephosphate isomerase deficiency (TPID) is a glycolytic pathway enzymopathy causing hemolytic anemia and neurologic dysfunction. TPID is caused by mutations in the TPI1 gene. These patients experience severe hemolytic anemia in infancy followed by progressive neurodegeneration. Diagnosis of TPID is made by measuring decreased TPI enzyme activity elevated dihydroxyacetone phosphate (DHAP) levels in the blood. The diagnosis is confirmed by molecular genetic testing. Neurological involvement typically manifests between 6 and 24 months of age, causing progressive motor dysfunction. Chronic axonal neuropathy is often present on nerve biopsy, and peripheral neuropathy is evident on electrophysiologic studies. Splenectomy and blood transfusions …