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Articles 29011 - 29040 of 1823837
Full-Text Articles in Entire DC Network
Early Parenting Stress And Later Abuse Risk: Dyadic Mediation By Maternal And Paternal Negative Attributions, Jewelian N. Fairchild
Early Parenting Stress And Later Abuse Risk: Dyadic Mediation By Maternal And Paternal Negative Attributions, Jewelian N. Fairchild
Psychology Theses & Dissertations
Parenting stress and negative parental attributions are key contributors to child abuse risk. Early parenting stress may increase a parent’s risk of negatively appraising their child’s behaviors, which, in turn, may influence their likelihood of harsh or abusive parenting. Grounded in Social Information Processing (SIP) Theory, the present study explored how these processes evolve over time and differ between mothers and fathers. Specifically, this study investigated whether parental negative attributions mediated the relationship between early parenting stress and later abuse risk. A sample of 203 first-time mothers and 151 of their male partners were recruited prenatally as part of a …
Tokenized Real Estate: The Law And Tech Of Digital Deeds, Christopher K. Odinet, Andrea Tosato
Tokenized Real Estate: The Law And Tech Of Digital Deeds, Christopher K. Odinet, Andrea Tosato
Faculty Scholarship
The advent of blockchain technology has generated bold claims that non-fungible tokens (NFTs) can fundamentally transform real estate. Proponents assert that digital assets can tokenize real property interests: the concept of using digital tokens to represent ownership rights in physical property. Their goal is to allow buyers and sellers to transfer real estate through simple blockchain transactions, thereby eliminating traditional intermediaries, reducing costs, and accelerating deal velocity. This Essay provides the first comprehensive legal analysis examining whether American law actually supports such a direct tokenization of real estate rights.
Our investigation reveals a stark disconnect between technological capability and legal …
The Association Between Physical Activity, Sedentary Time, And Sleep With Risk Of Hepatocellular Carcinoma In Patients With Cirrhosis, Samuel Ma, Yossef Alsabawi, Fasiha Kanwal, Hao Duong, Laith Elserag, Amit G Singal, Nicole E Rich, Saira Khaderi, Sumeet K Asrani, Hashem B El-Serag, Aaron P Thrift
The Association Between Physical Activity, Sedentary Time, And Sleep With Risk Of Hepatocellular Carcinoma In Patients With Cirrhosis, Samuel Ma, Yossef Alsabawi, Fasiha Kanwal, Hao Duong, Laith Elserag, Amit G Singal, Nicole E Rich, Saira Khaderi, Sumeet K Asrani, Hashem B El-Serag, Aaron P Thrift
Faculty, Staff and Students Publications
Background: The majority of hepatocellular carcinoma (HCC) cases arise in patients with cirrhosis, with known major risk factors of hepatitis B (HBV) or C (HCV) infection, metabolic dysfunction-associated steatotic liver disease (MASLD), and alcohol-associated liver disease (ALD). However, the impact of additional risk factors that act independently or jointly on the pathogenesis of HCC in cirrhosis patients is unknown. The aim of this study was to determine whether sleep, sedentariness, or physical activity levels play a role in the progression of cirrhosis to HCC.
Methods: We systematically collected data on sleep, sedentary time, and physical activity from the ongoing prospective …
Development And Internal Validation Of A Pretransplant Biomarker Panel For Mortality Prediction Following Liver Transplant, Guergana G Panayotova, Sopio Simonishvili, Lianhua Jin, Duc T Nguyen, Edward A Graviss, Yong Qin, Anastasia Xynogala, Tumininu Ayorinde, Laurie J Minze, Alexander Lemenze, Krupa R Mysore, Julie M Corkrean, Linda W Moore, Flavio Paterno, Ashish Saharia, Constance M Mobley, Arpit Amin, Mark J Hobeika, Xian C Li, Paul J Gaglio, R Mark Ghobrial, James V Guarrera, Keri E Lunsford
Development And Internal Validation Of A Pretransplant Biomarker Panel For Mortality Prediction Following Liver Transplant, Guergana G Panayotova, Sopio Simonishvili, Lianhua Jin, Duc T Nguyen, Edward A Graviss, Yong Qin, Anastasia Xynogala, Tumininu Ayorinde, Laurie J Minze, Alexander Lemenze, Krupa R Mysore, Julie M Corkrean, Linda W Moore, Flavio Paterno, Ashish Saharia, Constance M Mobley, Arpit Amin, Mark J Hobeika, Xian C Li, Paul J Gaglio, R Mark Ghobrial, James V Guarrera, Keri E Lunsford
Faculty, Staff and Students Publications
Importance: Current pretransplant clinical scoring systems fail to accurately estimate post-liver transplant (LT) survival, making recipient selection challenging. Persistent immune dysfunction contributes to early LT recipient mortality but is not captured by existing models.
Objective: To identify plasma biomarkers of pretransplant immune dysfunction and to develop a biomarker-based pre-LT risk stratification tool to predict post-LT mortality.
Design, setting, and participants: Prospective biomarker analysis of consecutively enrolled adult LT recipients was conducted. Healthy controls were included for baseline comparison. Patients undergoing LT at Houston Methodist Hospital (October 1, 2013, to December 31, 2017) and Rutgers/University Hospital (January 1, 2019, to March …
Analyzing Pressure Injury Trends Among Hospitalized Older Adults From Tarrant County, Oluwafunto M. Olorundare
Analyzing Pressure Injury Trends Among Hospitalized Older Adults From Tarrant County, Oluwafunto M. Olorundare
2026 Spring Honors Capstones Projects
Pressure injuries occur when skin and underlying tissues are damaged due to unrelieved pressure that reduces blood circulation to the affected area. Hospitalized older adults are vulnerable to pressure injuries due to factors such as limited mobility, physiological changes associated with aging, chronic conditions, and longer hospital stays. Despite multiple studies on the prevalence and incidence of pressure injuries at the national and global levels, there is limited research that analyzes trends among hospitalized older adults at the county level, specifically Tarrant County. This research aims to examine pressure injury trends among hospitalized older adults residing in Tarrant County. Using …
Natural Convection Of Cuo-Water Nanofluid Flow Along A Vertical Plate With Variable Thermophysical Properties And Discrete Heat Sources, Nepal Roy, Ioan Pop, Rama Subba Reddy Gorla
Natural Convection Of Cuo-Water Nanofluid Flow Along A Vertical Plate With Variable Thermophysical Properties And Discrete Heat Sources, Nepal Roy, Ioan Pop, Rama Subba Reddy Gorla
Faculty Publications
Effects of discrete heat sources along a vertical plate are of practical importance due their occurrence in electronic devices. For growing demand of electronic appliances and their advancement, cooling processes of them must be improved. As usual fluids have limited heat transfer, nanofluids made by dispersing nanoparticles into them are utilized to enhance thermal performance. However, flow characteristics and heat transfer of a nanofluid for discrete heat sources along a vertical plate need to be explored. For this reason, this study analyzes the natural convective heat transfer and flow behaviors of CuO-water nanofluid induced by discrete heat sources along a …
Radiation Protection Factor Research: The Keystone For Conventional-Nuclear Integration (Cni), Andrew W. Decker
Radiation Protection Factor Research: The Keystone For Conventional-Nuclear Integration (Cni), Andrew W. Decker
Faculty Publications
This article briefly describes Defense Threat Reduction Agency (DTRA) vehicle Radiation Protection Factor (RPF) research and explains its critical role in enabling future Operations in a Nuclear Environment (ONE) and Conventional-Nuclear Integration (CNI) on behalf of the US Department of War (DoW).1 As such, the background and practical utility of RPF values is discussed, as well as the justification for renewed Army and DoW investment into RPF research to enhance Joint military planning, survivability, and lethality on tomorrow’s nuclear battlefields. Advances in DTRA RPF research directly strengthen US strategic and extended deterrence efforts and support all Agencies and Departments responsible …
Novel Variants Identified In Families With Snx27 -Related Neurodevelopmental Disorder, Aiding In Characterizing Its Genotypic And Phenotypic Spectrum, Tayyaba Shan, Abrar Hussain, Anushree Acharya, Mulazim Hussain, Yumei Li, Hafiz Muhammad Jafar Hussain, Kiran Afshan, Suzanne M Leal, Rui Chen, Asif Mir, Isabelle Schrauwen, Sabika Firasat
Novel Variants Identified In Families With Snx27 -Related Neurodevelopmental Disorder, Aiding In Characterizing Its Genotypic And Phenotypic Spectrum, Tayyaba Shan, Abrar Hussain, Anushree Acharya, Mulazim Hussain, Yumei Li, Hafiz Muhammad Jafar Hussain, Kiran Afshan, Suzanne M Leal, Rui Chen, Asif Mir, Isabelle Schrauwen, Sabika Firasat
Faculty, Staff and Students Publications
Background:
Sorting Nexin 27 (SNX27), a key regulator of synaptic receptor trafficking and endosomal recycling, has been implicated in maintaining synaptic homeostasis and cognitive function. To date, variants in SNX27 have been reported in a small number of patients across three publications with severe neurodevelopmental phenotypes. However, the genetic and functional landscape of SNX27-related disorders remains poorly understood, and further evidence is needed to confirm its association with disease and to better delineate the associated phenotype.
Methods and Results:
Two unrelated Pakistani families with a total of five affected individuals segregating a neurodevelopmental disorder were investigated via exome …
Matlas-42, A Globular Cluster-Rich Ultra-Diffuse Galaxy That Diverges From The ‘Failed Galaxy’ Formation Pathway, Jonah S. Gannon, Duncan A. Forbes, Francine R. Marleau, Anna Ferré-Mateu, Aaron J. Romanowsky, Maria Luisa Buzzo, Jean P. Brodie
Matlas-42, A Globular Cluster-Rich Ultra-Diffuse Galaxy That Diverges From The ‘Failed Galaxy’ Formation Pathway, Jonah S. Gannon, Duncan A. Forbes, Francine R. Marleau, Anna Ferré-Mateu, Aaron J. Romanowsky, Maria Luisa Buzzo, Jean P. Brodie
Faculty Research, Scholarly, and Creative Activity
To date, there has been significant interest in globular cluster (GC)-rich ultra-diffuse galaxies (UDGs) and the evidence that they have formed via an unexpected, ‘failed galaxy’ formation pathway. The majority of the evidence for ‘failed galaxy’ UDGs originates from spectroscopic observations targeting passive GC-rich UDGs, with a focus on those residing in galaxy clusters. In this work, we study the gas-rich, GC-rich group UDG MATLAS-42 and derive its stellar population properties using the Keck Cosmic Web Imager. We measure a redshift for the galaxy (VR,⋆ = 2433 ± 8 km s-1), confirming the previous assumptions that it is …
The Implications Of The Midyear Departure Of Residence Directors In Housing And Residential Life, Chelsea Titus
The Implications Of The Midyear Departure Of Residence Directors In Housing And Residential Life, Chelsea Titus
Electronic Theses and Dissertations
High attrition rates among entry-level student affairs professionals have been documented for decades, yet little research has examined the implications of midyear departures within housing and residential life. Residence directors serve as live-in professionals responsible for crisis response, student conduct, staff supervision, and community development. When a midyear departure occurs, the disruption extends beyond the vacancy and affects supervisors, colleagues, and residential communities. The problem addressed in this study was the organizational and supervisory impact of midyear residence director departures. The purpose of this qualitative narrative inquiry was to examine the factors contributing to midyear departures and to explore how …
Exploring The Way Up: Career Paths, Challenges, And Resilience Among Women Leaders In Higher Education, Angela M. Brown
Exploring The Way Up: Career Paths, Challenges, And Resilience Among Women Leaders In Higher Education, Angela M. Brown
Electronic Theses and Dissertations
Women represent the majority of students and faculty in higher education students in higher education in the United States, yet they remain underrepresented in executive leadership positions. Women pursuing these roles encounter unique challenges, and institutions have increasingly recognized the value of mentoring and sponsoring women who aspire to leadership. Guided by Kumar’s CR8 resilience theory, this qualitative descriptive study explored how women leaders in higher education in the United States describe their career pathways to leadership, the challenges they encounter, and the impact of mentoring/sponsoring in developing their resilience for career progression. Semistructured interviews were conducted with 11 women …
Bridging The Divide: Exploring Stigma And Enhancing Belonging For Online Faculty In Higher Education, Stephanie L. Wanamaker
Bridging The Divide: Exploring Stigma And Enhancing Belonging For Online Faculty In Higher Education, Stephanie L. Wanamaker
Electronic Theses and Dissertations
Online faculty in higher education experience stigma and negative perceptions regarding online education in academia. Despite the rapid growth and success of online education, negative perceptions and stigma have not evolved at the same pace as the success of online institutions. Many online faculty members frequently experience skepticism, criticism, and marginalization from their residential counterparts within their academic communities. As a result of these experiences, online faculty are experiencing a reduced level of belonging, contributing to increased levels of burnout, poor satisfaction, and struggles with professional identity. Despite these experiences, little is known about the problem or how online faculty …
Reducing Humpty Dumpty Syndrome In Pediatric Inpatients, Jeanene Burns
Reducing Humpty Dumpty Syndrome In Pediatric Inpatients, Jeanene Burns
Electronic Theses and Dissertations
The Doctor of Nursing Practice project examined pediatric inpatient falls. The healthcare agency involved in the project identified concerns regarding pediatric inpatient falls. Data were collected on pediatric inpatient falls that occurred on two nursing units at this agency based on the Generalized Risk Assessment for Pediatric Inpatient Falls and the Humpty Dumpty Falls Prevention Scale. Results from the project indicated marginal statistical significance, with approximately a 60% reduction in falls after the implementation of the Humpty Dumpty Falls Prevention Scale. A recommendation for future research is a comparison of the two pediatric fall risk assessment tools after the Humpty …
How Can Learning Management Systems Positively Impact Student Engagement In Online Courses?, Jerald P. Wilson
How Can Learning Management Systems Positively Impact Student Engagement In Online Courses?, Jerald P. Wilson
Electronic Theses and Dissertations
The topic of this dissertation is learning management systems, specifically Canvas. Research has proven that student engagement is a strong factor in student achievement in both online and inperson courses. The COVID-19 pandemic highlighted a deficit in instructors’ ability to acquire and maintain student engagement in online courses. This study details why this problem exists and how instructors have successfully addressed it in higher-level online courses. The primary purpose of this qualitative descriptive study was to examine how learning management systems, specifically Canvas, can increase student engagement in online courses in higher education. Qualitative research was the chosen paradigm for …
Identifying The Barriers Bilingual Parents Face In The Special Education Process, Miranda Leah Hernandez
Identifying The Barriers Bilingual Parents Face In The Special Education Process, Miranda Leah Hernandez
Electronic Theses and Dissertations
Increasing parental involvement in the special education process means parents, teachers, and school administrators can unite to educate the children. The problem that the researcher identified was that emergent bilingual families struggle to become meaningful participants in their children’s individualized education plans. This was a qualitative case study that identified the barriers that bilingual parents face within the special education process and the recommendations from bilingual parents on how to help them become more meaningful members of their child’s individualized education plan. The population within the research included bilingual families with children in the greater Houston, Texas area who have …
Utility Of Diagnostic Arthroscopy Before Medial Patellofemoral Ligament Reconstruction In Pediatric And Adolescent Patients Without Articular Findings On Magnetic Resonance Imaging, Holden Archer, Kaleb Patterson, Jonathan D Schwartzman, Scott D Mckay, Indranil Kushare
Utility Of Diagnostic Arthroscopy Before Medial Patellofemoral Ligament Reconstruction In Pediatric And Adolescent Patients Without Articular Findings On Magnetic Resonance Imaging, Holden Archer, Kaleb Patterson, Jonathan D Schwartzman, Scott D Mckay, Indranil Kushare
Faculty, Staff and Students Publications
BACKGROUND: Medial patellofemoral ligament (MPFL) reconstruction is frequently used to manage recurrent patellar instability. Diagnostic arthroscopy is commonly performed before MPFL reconstruction to identify, confirm, and address intra-articular pathology. However, when preoperative magnetic resonance imaging (MRI) does not demonstrate intra-articular lesions, it is unclear how often diagnostic arthroscopy in pediatric patients alters surgical management.
PURPOSE: To determine the utility of diagnostic arthroscopy in young patients undergoing MPFL reconstruction who had no intra-articular chondral or osteochondral pathology, meniscal tears, or loose bodies identified on preoperative MRI, and to characterize intra-articular pathology detected on arthroscopy but not identified on MRI.
STUDY DESIGN: …
Aht Diagnoses: The Influences Of Clinical Presentation And Evidence Of Impact, Ruairi Smith-Dewey, Angela Bachim, Colleen Bressler, Kristine Campbell, Lori Frasier, Christopher Greeley, Danielle Horton, Nicole Johnson, Jan Leonard, Megan M Letson, Caitlin Mcnamara, Ashley Sherman, Shalon Nienow, Stuart Sommers, Joanne N Wood, James Anderst
Aht Diagnoses: The Influences Of Clinical Presentation And Evidence Of Impact, Ruairi Smith-Dewey, Angela Bachim, Colleen Bressler, Kristine Campbell, Lori Frasier, Christopher Greeley, Danielle Horton, Nicole Johnson, Jan Leonard, Megan M Letson, Caitlin Mcnamara, Ashley Sherman, Shalon Nienow, Stuart Sommers, Joanne N Wood, James Anderst
Faculty, Staff and Students Publications
Background: The frequency of abusive head trauma (AHT) diagnoses by child abuse pediatricians (CAPs), especially regarding external evidence of head impact, has been questioned.
Objectives: To compare CAP diagnoses in subjects with subdural hemorrhage (SDH) across clinical presentations, including subgroups with and without external evidence of head impact. Additionally, we aimed to describe subjects with SDH and concomitant suspicious injuries (CSI) without evidence of head impact.
Participants and setting: Multicenter retrospective study including subjects < 24 months old with SDH.
Methods: Subjects were divided into groups based on clinical presentations: Ill SDH only, Non-ill SDH only, and SDH + CSI. Groups were subcategorized based on presence/absence …
Shaping The Medical Educators Of Tomorrow: Developing Residents' Teaching And Educational Scholarship Skills, Devang Pastakia, Jen King, Alyssa Schlotman, Ryan Hanson, Kyle Langford, Lauren Starnes, Ryan Wolf, Tara Minor
Shaping The Medical Educators Of Tomorrow: Developing Residents' Teaching And Educational Scholarship Skills, Devang Pastakia, Jen King, Alyssa Schlotman, Ryan Hanson, Kyle Langford, Lauren Starnes, Ryan Wolf, Tara Minor
Presentations
It is widely accepted that residents play an integral role in educating medical students.1 It is estimated that medical students receive approximately one-third of their clinical education from residents.2 It has been demonstrated that good education from residents positively impacts medical student clerkship satisfaction and influences career choices.2 Despite the fact that residents participate in educational responsibilities and many residents want to incorporate medical education into their future careers, residencies often do not have programs that provide a foundation for developing future medical educators.3 Dedicated programs may also serve as an avenue through which residents can explore medical education careers …
Exploring How Parental Involvement Impacts Police Encounters And Delinquent Behaviors Among Black Adolescent Girls, Danielle Porter, Elizabeth A. Otto, Dyamon Brown, Jasmine Alli, Robyn Douglas, Noni Gaylord-Harden
Exploring How Parental Involvement Impacts Police Encounters And Delinquent Behaviors Among Black Adolescent Girls, Danielle Porter, Elizabeth A. Otto, Dyamon Brown, Jasmine Alli, Robyn Douglas, Noni Gaylord-Harden
Presentations
Adolescents’ contact with police is a complex outcome that is influenced by both individual behavior and the broader social context. Specifically, while delinquent behavior can lead to more police contact (Crutchfield et al., 2012), hyper-surveillance often occurs in marginalized communities, increasing unjustified police contact for youth of color (Campos-Manzo et al., 2020; Geller, 2021). Indeed, racial disparities in police contact during adolescence persist even after accounting for delinquent behavior (Campos-Manzo et al., 2020; Crutchfield et al., 2012). Thus, it is important to identify factors that may protect Black youth from contact with police. Parental involvement refers to parents’ active and …
Interventions For Reducing Barriers To Future Employment Success In First-Generation College Students., Kellie M. Burke
Interventions For Reducing Barriers To Future Employment Success In First-Generation College Students., Kellie M. Burke
Doctor of Social Work Capstone Projects
First-generation college students (FGCS) comprise a significant and diverse segment of the U.S. undergraduate population, yet they remain disproportionately vulnerable to barriers that impede both academic achievement and career advancement. These challenges, rooted in intersecting factors (e.g., race & gender), are amplified by institutional structures that inadequately address the realities faced by FGCS. Despite the proliferation of career development programs, internship participation, and subsequent employment, among FGCS remains notably low, revealing persistent gaps in support, access, and program efficacy.
This qualitative study evaluates the Rising Leaders Program, an agency-driven intervention designed to promote career readiness for FGCS at Kentucky universities …
Exploring The Professional Quality Of Life Of Female Collegiate Head Coaches., Jennifer Marie Boa
Exploring The Professional Quality Of Life Of Female Collegiate Head Coaches., Jennifer Marie Boa
Doctor of Social Work Capstone Projects
Before Title IX passed in 1972, most female college sports teams were coached by women. Today, only 42% of head coaches are women, even though participation in women’s collegiate sports has increased by 637% since 1971. This study explored the factors influencing the professional quality of life of female college coaches. Variables considered in this study included parenting and work, organizational culture, women’s role in the workforce, unique issues faced by female collegiate coaches, and professional quality of life. The study used a mixed-methods cross-sectional design and purposive sampling, resulting in 107 valid responses. The results indicate that respondents felt …
Assessing The Relationship Between Professional Discipline And Perceptions Of Team Functioning Within Hospital-Based Multidisciplinary Child Abuse Teams., Nikki Roth
Doctor of Social Work Capstone Projects
Abstract
Assessing the Relationship Between Professional Discipline and Perceptions of Team Functioning Within Hospital-based Multidisciplinary Child Abuse Teams
Nicolle Roth
04/03/2026
The multidisciplinary team (MDT) approach, professionals from various disciplines collaborating to solve a problem, has been used for decades in both child welfare and medicine. Benefits of the multidisciplinary approach have been documented through studies in both in the field of child abuse and the medical field and include improved outcomes, shortened intervention timelines, and economic advantages. Although multidisciplinary teamwork has been shown to be effective, not all professionals have the same level of skill in working within a …
Oral History Of Dr. Edward Yost, Conducted On February 14, 2026 By Mallory Lough, Edward Yost, Mallory Lough
Oral History Of Dr. Edward Yost, Conducted On February 14, 2026 By Mallory Lough, Edward Yost, Mallory Lough
HIST 4798/5798: Recording Memory: Methods and Uses of Oral History
This interview, conducted by Mallory Lough in February 2026, documents the life and career of Dr. Edward Yost, a retired professor from Ohio University’s College of Business. Dr. Yost grew up in rural Litchfield, Ohio, where he was part of a fourth-generation dairy farming family. After his family’s farm declined, he pursued higher education using the GI Bill, eventually earning a PhD in Business Administration. Mentorship played a key role in guiding him into academia. At Ohio University, where he spent over 30 years, Yost held numerous leadership roles, particularly in graduate and international business programs. He helped develop and …
Information-Content-Informed Kendall-Tau Correlation Methodology, Robert M. Flight, Praneeth S. Bhatt, Hunter N.B. Moseley
Information-Content-Informed Kendall-Tau Correlation Methodology, Robert M. Flight, Praneeth S. Bhatt, Hunter N.B. Moseley
Markey Cancer Center Faculty Publications
Background: Almost all correlation measures currently available are unable to directly handle missing values. Typically, missing values are either ignored completely by removing them or are imputed and used in the calculation of the correlation coefficient. In either case, the correlation value will be impacted based on the perspective that the missing data represents no useful information. However, missing values occur in real datasets for a variety of reasons. In metabolomics datasets a major reason for missing values is that a specific measurable phenomenon falls below the detection limits of the analytical instrumentation (left-censored values). These missing data are not …
Role Of Succinate Dehydrogenase In Age-Related Th17 Inflammation, Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica-Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath
Role Of Succinate Dehydrogenase In Age-Related Th17 Inflammation, Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica-Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath
Markey Cancer Center Faculty Publications
Age-related cellular changes negatively impact CD4+ T cell function. Our prior work showed that mitochondrial complex II (succinate dehydrogenase [SDH]) expression was upregulated in T cells from older (O) adults (60–80 years old). T cells from older adults also produced higher amounts of cytokines generally considered proinflammatory, such as Th17 cytokines IL-17A/F and IL-21, and the Th-17-supportive cytokine IL-6, compared to T cells from younger (Y) adults (25–40 years old). The objective of our study is to evaluate whether hyperactivation of SDH is required for the induction of proinflammatory cytokines and the mechanistic link between SDH and Th17 cytokine …
Systemic Consequences Of Chronic Ethanol Intake, Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann
Systemic Consequences Of Chronic Ethanol Intake, Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann
Markey Cancer Center Faculty Publications
Chronic ethanol (EtOH) consumption is a major contributor to multi-organ dysfunction, yet its systemic effects remain incompletely understood. To address this, we utilized a physiologically relevant long-term mouse model, administering 20% EtOH in drinking water for 60 weeks, to investigate the integrated consequences of chronic exposure. EtOH-consuming mice (0.4–0.5 mL/day) exhibited > 30% reductions in chow and fluid intake, resulting in a 12% decrease in total caloric intake compared to controls (p < 0.001). Body mass remained similar until Week 52, after which EtOH-treated mice had lower body mass due to reductions in both lean and fat mass (p ≤ 0.004). Functional assessments revealed impaired treadmill endurance (−17%) and grip strength (−11%) (p ≤ 0.037), while motor coordination remained unaffected (p = 0.203). Chronic EtOH exposure significantly altered gut microbiota composition, reducing Lactobacillus and enriching Faecalibaculum, Clostridium, and Bifidobacterium at the genus level. These changes were accompanied by marked depletion of short-chain fatty acids (p ≤ 0.05). Indirect markers of gut permeability (serum LPS & zonulin) and liver injury (serum ALT & AST, hepatic amyloid content) were elevated, alongside increased total cholesterol and > 62% upregulation of hepatic TNFα, IL-6 & serum amyloid A (p ≤ 0.046). EtOH also induced dyslipidemia and glucose intolerance (p ≤ 0.041), although transcriptomic changes in white adipose …
Freedom Readers And Sustainable Development Goal 4: Advancing Literacy In Low-Income Communities Of South Carolina, Madison Hayes
Freedom Readers And Sustainable Development Goal 4: Advancing Literacy In Low-Income Communities Of South Carolina, Madison Hayes
Goal 4: Quality Education
No abstract provided.
Growth With New And Old Technologies, Bernardo Ribeiro
Growth With New And Old Technologies, Bernardo Ribeiro
Cowles Foundation Discussion Papers
This paper proposes a semi-endogenous growth theory that incorporates technology vintages and the endogenous evolution of multiple technological paradigms through innovation. It provides a characterization of both balanced growth equilibrium and transitional dynamics in an environment where new technologies continuously emerge. From a positive perspective, the model rationalizes two distinct empirical patterns. Using two centuries of US patent data, I first document that the age profile of patents has a pronounced hump shape: most contemporary patents build upon technologies that are between 50 and 100 years old. Second, this age profile has remained stable throughout the past century. From a …
Capital Flows And The Global Collateral Cycle, Ana Fostel, John Geanakoplos, Gregory Phelan
Capital Flows And The Global Collateral Cycle, Ana Fostel, John Geanakoplos, Gregory Phelan
Cowles Foundation Discussion Papers
Cross-country disparities in collateral technologies alone can account for large capital flows among mature economies, and allow the most advanced country to run a permanent trade deficit. When the collateral technology advantage is in creating negative beta (super safe) financial assets backed by positive beta assets, a Global Collateral Cycle emerges, with pro-cyclical gross and net flows and increased global asset price volatility. The supply of super safe assets is necessarily curtailed in downturns, providing a complementary (supply) channel to the flight to safety (demand) channel for explaining why US safe asset prices rise during crises.
Decarceration & Voting Rights Advocacy, Sophie E. Trudgeon
Decarceration & Voting Rights Advocacy, Sophie E. Trudgeon
Graduate Student Portfolios, Professional Papers, and Capstone Projects
Portfolio detailing my MSW practicum placement at Catalyst MT under the Justice Initiative and the growth that accompanied it.