Digital Commons Network^™

An Elegy For The Hereditary Peers, Declan M. Hurley

Notre Dame JLEPP: In Limine

Declan Hurley reflects on the role of the hereditary peers, and what is lost with their demise.

A Problem For Traditionalism, Marc O. Degirolami

Notre Dame JLEPP: In Limine

Prof. DeGirolami explains traditionalism and why it might pose a problem in the United States.

The Crime We Forget? White-Collar Crime: Problems In Defining Motive And Enforcement Of Followers, John Stillman

Notre Dame JLEPP: In Limine

John Stillman explains problems in defining and enforcing against white-collar crime, focusing on followers.

Gulf Coast Faculty Council Minutes - April 16, 2026, Eric Saillant

Gulf Coast Faculty Council Minutes

No abstract provided.

Resilience Factors For Physical Activity After Completion Of Intensive Interdisciplinary Pain Treatment: A Qualitative Analysis., William R. Black, Lora L. Black, Jennifer Christofferson, Liesbet Goubert, Cara M. Hoffart, Dustin Wallace

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: This study explored potential resilience factors that facilitate engagement in physical activity (PA) among adolescents with chronic musculoskeletal pain after completing intensive interdisciplinary pain treatment.

METHODS: Ten adolescents aged 13 to 17 years with a history of chronic musculoskeletal pain from a mid-western pediatric hospital in the United States participated in this qualitative study. Participants provided demographic information and completed semistructured virtual interviews. The interviews focused on their pain experiences, resilience, and engagement in PA. Transcripts were analyzed using primarily directed content analysis based on a pain resilience framework.

RESULTS: Participants highlighted several key resilience factors that influenced their …

Proximal And Distal Factors Associated With Obesity In Childhood: An Exploratory Structural Equation Model., Joseph A. Skelton, Erinn T. Rhodes, Sarah Hampl, Ihuoma Eneli, Edward H. Ip, Sit Study Research Group

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Obesity in childhood is complex; structural equation modeling (SEM) offers an approach to ascertain complicated relationships between weight and proximal (health behaviors, child health) and distal (family/household, community) variables. The objective of the study was to use SEM to map the influence of different etiological clusters on obesity in childhood.

METHODS: Secondary analysis of baseline data from patients and parents enrolled in a multi-site study of pediatric weight management was conducted. The primary outcome was weight status (utilizing percentage above the 95th percentile BMI, %95BMI). SEM was used to evaluate the influences of variables proximal and distal to child …

Confessions In Cases Of Child Physical Abuse-A Capnet Study., Margaret R. Russell, Antoinette L. Laskey, Henry T. Puls, Suzanne P. Starling, Joanne N. Wood, Daniel M. Lindberg, Nancy S. Harper, Caitlin R. Mcnamara, Angela W. Bachim, Farah W. Brink, Lori D. Frasier, James Anderst, Porcia Vaughn, Kristine A. Campbell

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Prior research on confessions of physical abuse (PA) has explored mechanisms of injury. Little is known about conditions supporting a confession of abuse or how confessions may influence case outcomes.

METHODS: This cross-sectional study of suspected PA in children aged < 10 years at 10 centers participating in CAPNET, a multicenter child PA research network, included children with in-person Child Abuse Pediatrics (CAP) consultations between February 2021 and December 2022 and excluded children without injury. Our focus was a confession of inflicted injury known to the CAP during clinical involvement. We compared child and clinical characteristics, out-of-home (OOH) placements, and arrests between cases with and without confessions. Multivariable models using generalized estimating equations (GEE) produced adjusted predicted probabilities (APP) clustering by CAPNET site.

RESULTS: Confessions were known to CAPs in 115/4297 (2.7%) cases, with significant site variability. In a multivariable GEE model, confessions were more likely in cases with injuries with high specificity for abuse (APP 6.0% vs 1.6%, P < .001), near-fatality (APP 5.6% vs 2.3%, P < .001), and older children (APP 4.8% vs 2.5%, P = .025). OOH placements and arrests were more common in cases with confessions. CAP awareness of confessions, OOH placements, and arrests did not follow racial or ethnic patterns seen in the US child welfare system. Lower socioeconomic status was associated with OOH placements and arrests but not with CAP awareness of confessions.

CONCLUSIONS: Our findings highlight differences in case characteristics and outcomes where a confession is known to the CAP and raise questions about …

Exploitive Adolescent Labor And Labor Trafficking: Clinical Perspectives For Adolescent Healthcare Providers., Romina Barral, Michele A. Kelley, Abigail English, Marissa Raymond-Flesch, Tonya Chaffee, Veronica Svetaz, Tamera Coyne-Beasley, Nuray Kanbur

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Using Gloves Wisely: Rethinking Glove Use For Health, Safety, And Environmental Sustainability., M Lauren Lalakea, Radhika Sheth, Elizabeth Cerceo, Yvonne Huckleberry, Preeti Jaggi, Vidya Mony, Elizabeth Monsees

Manuscripts, Articles, Book Chapters and Other Papers

Non-sterile gloves (NSG) are essential for reducing transmission of pathogens and for protecting patients and staff. Their overconsumption can lead not only to an increased risk of cross-contamination but also increased plastic waste and downstream environmental effects. Glove reduction campaigns worldwide have safely and successfully reduced their inappropriate use and associated waste. In this multidisciplinary commentary, we discuss the sweeping public health and environmental consequences of NSG overuse and strategies to implement a successful glove stewardship campaign.

April 2026, Robert Kelly

Robert Kelly Manuscripts

No abstract provided.

Visual Recognition Of The Anteroposterior Female Body Axis Drives Spatial Elements Of Male Courtship In Drosophila, Ross M Mckinney, Christian Monroy Hernandez, Yehuda Ben-Shahar

2020-Current year OA Pubs

Drosophila males exhibit a highly stereotypic courtship ritual toward virgin females, which is comprised of a sequence of specific behavioral elements that depend on inputs from diverse sensory modalities. Particularly, the visual system of the male plays an important role in detecting salient patterns, colors, and motion cues from conspecifics, which can promote or inhibit specific aspects of male courtship such as chase and song production. Here, we use a computer vision and machine learning-based approach, with a simplified courtship paradigm, to show that males also depend on visual cues to determine the anterior-posterior body axis of females, which drives …

Automating Evaluation Of Llm-Generated Responses To Patient Questions About Rare Diseases, Min Zhao, Inez Y Oh, Aditi Gupta, Sally Cohen-Cutler, Kathryn M Harmoney, Albert M Lai, Bryan A Sisk

2020-Current year OA Pubs

OBJECTIVES: Patients with rare diseases often struggle to find accurate medical information, and large language model (LLM)-based chatbots may help meet this need. However, evaluating LLM-generated free-text answers typically requires physician review, which is time-consuming and difficult to scale. This study compared traditional natural language processing (NLP) metrics to emerging LLM-based evaluation approaches for assessing answer quality in the context of Complex Lymphatic Anomalies (CLAs).

MATERIALS AND METHODS: We compiled 25 common patients' questions about CLAs and generated 175 responses to these questions from seven LLMs. Three expert physicians scored these responses for accuracy. We compared these physician-assigned scores with …

Neurofibromatosis Type 1-Plexiform Neurofibromas: Integrating Treatment Across Pediatric And Adult Populations, Amy E Armstrong, Andrea M Gross, Laura J Klesse, Steven D Rhodes, Shivani Ahlawat, Verena Staedtke, Camilo A Molina, Angela C Hirbe

2020-Current year OA Pubs

Plexiform neurofibromas (PNs) are a hallmark of neurofibromatosis type 1 (NF1), affecting ∼50% of individuals with the condition. Originating from Schwann cells and other peripheral nerve sheath components, these tumors can cause significant morbidity, including functional impairment, diminished health-related quality of life, chronic pain, and malignant transformation. Managing NF1-PNs is challenging because of disease variability, differing growth rates, and age-related differences in clinical presentation and treatment tolerability. This review examines current therapeutic strategies, including surgery, medical therapies, and emerging treatments, emphasizing individualized care. Highlighted here is the need for age-specific treatment planning, particularly as disease progression, comorbidities, and side-effect profiles …

An Artist’S Playground: Building Bridges Between Children’S Education And Their Knowledge Of Art Through Multi-Modal Learning, Alice J. Cauchi

Theses

Not all museums welcome children as part of their main audience with open arms. Research suggests that experiencing museums as a child supports classroom learning and development, but only when the museums engage young children properly. This paper explores how incorporating multi-modal interactives into art museums can effectively engage children, ages 4 to 8, and build a foundation that supports lifelong learning. Drawing on ideas from early-childhood education, museum visitor-engagement studies, and interactivity sciences, this project results in a framework that guides art museums on how they can overlap play, interactives, and content to incorporate this age group effectively to …

Under The Surface: A Scalable Experiential Framework For Accessible Design Archives, Lo Fasano

Theses

Preserving design history is usually done by hiding it away. While institutions like the Vignelli Center for Design Studies house over 750,000 artifacts, the vast majority remain in restricted storage, with minimal space dedicated to displaying process materials alongside canonical final works. Digital archives document portions of these collections, but typically present them as static image galleries, leaving the evolutionary logic of a design, and the human labor behind it, invisible to the public. Under the Surface is a scalable, interactive framework designed to bridge archival preservation and public discovery. By transforming preserved artifacts into real-time digital experiences, the project …

Imaging Performance Analysis Of Euv Mask Stacks For Sub-24 Nm Features At High And Hyper Numerical Aperture, Abdusame Omran N. Berish

Theses

As extreme ultraviolet (EUV) lithography advances toward high numerical apertures (NAs) of 0.55 and 0.75, mask-3D effects degrade image fidelity, limiting resolution and the process window. This work investigates the performance of alternative EUV absorber materials for sub-12 nm half-pitch patterning under high-NA and hyper-NA conditions. The lithographic simulations were conducted using the PROLITH Maxwell rigorous model under dipole illumination optimized for sub-24 nm resolution dense line/space features. The EUV mask stacks were derived from five fabricated and tested absorbers: TaBN, Ru/Ta, Pt2W, Ni/CrN, and TaSi2.  The absorber thickness was recalibrated to an optimal value, ensuring a maximum normalized image …

Adapting Specpt For Hst Grism Spectroscopy Via Transfer Learning, Clive Kalathoor Binu

Theses

This thesis demonstrates the successful application of transfer learning to bridge ground-based and space-based spectroscopic analysis through adapting SpecPT (Spectroscopy Pre-trained Transformer) for Hubble Space Telescope WFC3 grism data for redshift prediction. Originally trained on high-resolution DESI spectra, SpecPT initially failed when applied directly to low-resolution, noisy HST WFC3 grism observations (Normalized Median Absolute Deviation (NMAD) = 0.2095, catastrophic outlier fraction ($\eta$) = 47.97\%). Through transfer learning on 8,530 high-quality 3D-HST spectra with emission-line SNR > 2.5 and z < 1.7, the model achieved substantial improvement (NMAD = 0.0724, $\eta$ = 26.69\%), representing a 65\% reduction in typical redshift error and 46\% decrease in catastrophic failures. The research addresses two primary objectives: establishing transfer learning effectiveness for cross-domain spectroscopic analysis and investigating whether supplementing grism spectra with broadband photometric data enhances performance. Counterintuitively, integrating comprehensive multi-wavelength photometric data from CANDELS significantly degraded performance (NMAD = 0.1641, $\eta$ = 36.51\%), challenging conventional astronomical assumptions about multi-modal data fusion and revealing critical failure modes in astronomical machine learning. This work establishes a unified framework for automated analysis of both ground-based and space-based spectroscopic surveys, with important implications for JWST, Euclid, and the Nancy Grace Roman Space Telescope. The demonstrated capability to adapt models across instrumental domains provides a scalable approach for processing large data volumes from next-generation missions, validating foundational model approaches that can be developed once and efficiently adapted across diverse observational contexts.

Sampling And Counting Graph Structures With Triangle Motifs, Sherry Robinson

Theses

Understanding the structure of real-world networks often relies on identifying significant (i.e., occurring significantly more frequently than random) subgraph patterns, or motifs, such as triangles. To assess their significance, null models generate random samples from a constrained distribution of graphs, preserving selected properties while randomizing others. These models may either generate random graphs or sample structures from a fixed input graph. This thesis focuses on the latter, specifically the problem of sampling and counting graph structures that incorporate triangle motifs. While efficient algorithms exist for sampling classical structures such as matchings, extending these methods to higher-order motifs remains an important …

Beyond Anomaly Detection: Classifying Attacker Automation Level From Ssh Honeypot Behavioral Signatures, Ashley Alt

Theses

The proliferation of AI-assisted offensive tools has introduced a new category of cyber attacker that combines the speed of automation with the adaptive reasoning previously associated only with skilled human operators. Despite the richness of behavioral data captured by SSH honeypots, existing analyses treat interaction logs primarily as evidence of malicious activity rather than as a dataset capable of distinguishing between attacker types. This thesis investigates whether human-driven, traditionally automated, and AI-assisted attackers produce distinguishable behavioral signatures within SSH honeypot interactions, and whether machine learning techniques can reliably classify attacker behavior from session-level features. A controlled experimental architecture was developed …

Preoperative Imaging For Cochlear Implantation: A Global Consensus, Farid Alzhrani, Craig Buchman, Et Al.

2020-Current year OA Pubs

OBJECTIVE: Preoperative imaging is vital for cochlear implant surgeries, aiding diagnosis, and surgical planning. This study evaluated global practices and the value of preoperative imaging through an international survey.

METHODS: A cross-sectional survey was conducted among international cochlear implantation experts using a 112-item questionnaire. The study explored imaging modalities, anatomical targets, evaluated parameters, and different imaging approaches' perceived value and risks. Participants were recruited from a global consortium of otolaryngology, otology, neurotology, and cochlear implant surgery professionals.

RESULTS: Thirty-nine practitioners from 36 centers in 16 countries completed the survey (95.1% response rate). All used computed tomography (CT) and magnetic resonance …

Mechano Responsiveness Of Neuroimmune Cross-Talk In Bone And Joints: A Narrative Review With Implications For Force-Based Manipulations, Karl J Lewis, Jennifer Bent, Per Gunnar Brolinson, Damian Keter, Ellen Lumpkin, Jan Mundo, Vitaly Napadow, William R Reed, Brent S Russell, Simon Y Tang, Mary F Barbe

2020-Current year OA Pubs

INTRODUCTION: Recent advances in osteoimmunology have illuminated the significant role of neuroimmune interactions in bone and joint health. The neuroimmune system critically regulates bone cell function through a complex network of molecular mediators - including signals from the sympathetic and parasympathetic nervous systems, pro- and anti-inflammatory cytokines, cortisol and other hormones, and growth factors. These mediators interact within a nonlinear network where each component can influence others reciprocally, with the brain serving as a central coordinator.

AIM: Our goal in this narrative review is to: 1) Provide an overview of roles the neuroimmune system is involved in bone and joint …

Sensitivity And Concordance Study Of An Open Source Epid-Based Linear Accelerator Test Suite, Lana C Critchfield, Cory S Knill, Ellie Durussel, Justin K Mikell, Michael Barnes, Michael Pillainayagam, William P Donahue, Seng Boh Lim, John J Demarco, Mario Perez, Nilendu Gupta, Hania Al-Hallaq, Richard A Popple, Jim Irrer, Jean M Moran

2020-Current year OA Pubs

BACKGROUND: Electronic portal imaging devices (EPIDs) enhance linear accelerator (linac) quality assurance (QA) efficiency but are not universally used beyond patient-specific IMRT QA. A multi-institutional Consortium seeks to standardize linac QA utilizing an EPID-based test suite.

PURPOSE: This study evaluates the sensitivity of a test suite to intentional linac and plan errors and the concordance with linac fluctuations over time.

METHODS: Baseline and error-introduced tests were performed on a Varian TrueBeam and Clinac. Evaluated parameters included enhanced dynamic wedge factors (EDW) (6MV), central axis dose (6MV, 6MV FFF, 16MV), focal spot alignment and beam symmetry (6MV, 16MV), dose rate-gantry speed …

Exosome-Mediated Decay Of Unstable Long Extended Precursors Of Human Telomerase Rna Is Dependent On 5'-Cap Trimethylation, Aniruddha Samajdar, Roberta Amato, Seongmoon Jo, Ethan Cordes, Albert Tai, Grazia Daniela Raffa, Luis F Z Batista

2020-Current year OA Pubs

Mutations that impact maturation of human telomerase RNA (hTR) are common in telomere biology disorders. Here, we describe sequential posttranscriptional modifications that coordinate hTR biogenesis and decay. Initially, TGS1-mediated 5'-cap trimethylation targets long genomically extended hTR precursors for degradation. Prevention of 5'-cap trimethylation results in accumulation of nucleolar 3'-end extended precursors, evading MTR4 recognition and degradation by the exosome. In a second step, 3'-end oligoadenylation by PAPD5 promotes degradation of mature hTR, a process that remains dependent on 5'-cap modifications, as prevention of trimethylation inhibits decay of heavily 3'-end oligoadenylated molecules. Combined inhibition of 5'-cap trimethylation and 3'-end oligoadenylation synergistically …

Cardiac Radiotherapy-Induced Epigenetic Memory Underlies Electrophysiologic And Metabolic Reprogramming, Samuel D. Jordan, Shuhua Fu, Abigail Fulkerson, Donghua Hu, Sherwin Ng, David M. Zhang, Sneha Manikandan, Jeffrey Szymanski, Nan Hu, Yuqian Xie, Anish Bedi, James Tabor, Lauren Boggs-Bailey, Lori Strong, Stephanie Hicks, Lavanya Aryan, Nishanth Gabriel, Geoffrey D. Hugo, Kuo-Chan Weng, Nathaniel Huebsch, Julie K. Schwarz, Bo Zhang, Stacey L. Rentschler

2020-Current year OA Pubs

Stereotactic arrhythmia radiotherapy (STAR) is emerging as a highly effective treatment for ventricular tachycardia (VT). Growing evidence indicates that STAR favorably reprograms the electrical substrate by speeding conduction and/or prolonging repolarization via modulation of ion channel expression, although the mechanisms by which single-fraction radiation mediates durable changes in gene expression are incompletely understood. Here, we identify dynamic changes in the cardiomyocyte epigenome and transcriptome after irradiation (IR) in vivo and in vitro, including durably increased expression and chromatin accessibility of Scn5a (encodes the α subunit of the sodium channel, NaV1.5), demonstrating a role for epigenetic memory in conduction velocity (CV) …

Enhancing Urban Garden Capacity By Linking Biodiversity And Ecosystem Function, Mary T. Nguyen, Carleen Rauh, Shelby Gresch, Charlotte Correiro, Heidi Elmendorf, Adriane Fugh-Berman, Gina Wimp, Alexandra L. Decandia

Virginia Journal of Science

Urban agriculture broadly describes food and plant cultivation in metropolitan areas. While biodiversity is thought to support ecosystem health and resilience, the relationship between above-ground and below-ground diversity has been understudied in urban green spaces. This study examines plant, animal, bacterial, and fungal diversity across three distinct urban habitats: a turf lawn, a forb garden, and a farming space. Using bacterial 16S rRNA and fungal ITS2 sequencing, soil nutrient analyses, and surveys of vegetation and wildlife, we connect diverse philosophies in urban agriculture to their role in advancing community diversity and ecosystem function. We found that different urban gardens support …

Deliberate Indifference Reimagined: Towards An Objective Standard For Eighth Amendment Prison Condition Violations, Lane Hines Woodke

Missouri Law Review

This Article critiques the existing standard for establishing deliberate indifference under the Eighth Amendment, which primarily relies on the subjective intent of correctional officials. It argues for a shift towards an objective standard that assesses the reasonableness of state responses to known risks, particularly in light of persistent unconstitutional conditions within correctional facilities, such as inadequate living conditions and unchecked violence. The Article contends that the current subjective approach creates an insurmountable evidentiary burden for incarcerated individuals and fails to ensure meaningful compliance with constitutional protections. By advocating for an objective framework akin to standards used in Fourth and Fourteenth …

Purpose Over Perception: Distinguishing Status From Viewpoint In A University’S Limited Public Forum, Haleigh J. Bachman

Missouri Law Review

In nearly every university, cultural centers and student organizations quietly provide tangible, essential support: one student finds a community to celebrate his shared heritage; another student finds guidance after struggling to obtain her necessary accommodations in class; an international student rehearses for a cultural showcase that will be the highlight of his semester. These spaces provide community, safety, and a sense of belonging that classrooms and lecture halls often do not. Nevertheless, public universities often face challenges in allocating physical space and funding resources to student organizations— particularly to those supporting cultural and affinity groups. On one hand, universities can …

Designing Surface-Induced Entatic States In Copper Complexes For Tunable Reactivity, Rachel Kiser

Senior Theses

Copper catalysts play an important role in electrocatalytic oxidation reactions due to their redox flexibility and relative abundance compared to noble metal catalysts. In biological systems, copper metalloenzymes often achieve enhanced reactivity through an entatic state. Entasis is described as an active site or metal center being constrained to a geometric and electronic state, minimizing primary sphere reorganization energy and achieving higher rates of electron transfer.  This study investigates whether entasis can be achieved in synthetic molecular catalysts by immobilizing Cu(I) complexes onto metal oxide surfaces. Two Cu(I) complexes bearing carboxylate-functionalized ligands were examined both in homogeneous solution and when …

Searching For Temporal Variations In The Fine-Structure Constant Using Espresso Spectrograph Data, David Hoffman Iv

Senior Theses

The fine-structure constant α is a dimensionless constant, defined as e²/(4πε₀ℏc) ≈ 1/137. On the order of human timescales, its value is very much unchanging, however, in recent years there has been extensive debate over whether or not the value of α has remained constant over cosmological timescales. With the natural corollary to a changing α being that either one or multiple of its constituent physical constants have also changed in value, observing a variation in the fine-structure constant would have vast ramifications for our understanding of the nature of the early universe and how it has evolved. While past …

Delenda Est Norfolk: The Tidewater Revolts!, Kiera Dillman, Alise Dunham, Kristen Gary, Olivia M. Haris, Nelliel A. Herrera, Logan Holzgrefe, R. J. Lynch, Adam M. Manis, David Mogan, Luke Pickard, Shayla M. Shaw, Landon Swain, Kenny Wilcox, Bailey M. Wimberly, Tracy L. Barnett

Student Projects

Introduction to the Exhibit:

Today—exactly 250 years after the signing of the Declaration of Independence—many Americans trace the origins of the nation’s revolutionary sentiment to Boston, Massachusetts or Philadelphia, Pennsylvania. We remember the violence of March 1770, when red-coated British soldiers fired into a crowded Boston street, massacring innocent colonists and igniting outrage. We recall the patriotic defiance of the Sons of Liberty, who boarded three East India Company ships and dumped chests of imported British tea into the Boston Harbor in December 1773. We can still hear, too, the reverberations of the “shot heard ’round the world,” when British …