Digital Commons Network^™

Nanog Proximity Proteomics Maps Neighborhood Hubs Linked To Mesenchymal Stem Cell Stemness And Chromatin Control, Allan Chris M Ferreon, Marian Kalocsay, Josephine C Ferreon

Faculty, Staff and Students Publications

NANOG overexpression has been reported to reverse aging-associated decline in mesenchymal stem/stromal cell (MSC) function, but the molecular machinery engaged by NANOG in MSCs remains incompletely defined. Here, we applied APEX proximity labeling coupled with quantitative mass spectrometry to define the NANOG proximity interactome (proxeome) in human MSCs. Of 1040 quantified proteins, 828 were significantly enriched in the APEX-NANOG (H2O2 labeling) samples, consistent with a broad NANOG-centered neighborhood rather than a single stoichiometric complex. Enriched proteins encompass RNA-processing pathways (including splicing/RNP factors and selected m6A-related proteins), transcriptional coactivation and elongation control (Mediator and 7SK/P-TEFb regulators), chromatin repression/poising modules (Polycomb and …

Kenyon Collegian - April 2, 2026

The Kenyon Collegian

No abstract provided.

Genetic Counselors With Doctorate Degrees: Career Profiles Based On Level Of Education, Alise Kathleen Blake

Electronic Theses and Dissertations Archive

Although genetic counseling is a health care profession requiring a terminal master’s degree, 4 to 6% of genetic counselors (GCs) hold a doctoral degree. The literature lacks information on how GCs who have doctorate degrees professionally differ from those who do not. Drawing from Cultural Historical Activity Theory, this quantitative study examines how post-secondary education, as a primary mediating tool, shapes career profiles within genetic counseling. Three research questions guided this study: (1) To what extent is the distribution of work environment, job title, and professional responsibilities different between GCs who have a doctorate degree and GCs who do not …

Continental Rift Evolution Under Time-Varying Plate Boundary Forces And Mantle Plumes: A Numerical Study, Kuruvitage Chameera Chathuranga Silva

Electronic Theses and Dissertations Archive

Continental rift evolution emerges from the dynamic interaction among far-field tectonic forces, mantle processes, and lithospheric rheology. Variations in plate-scale stress transmission and thermomechanical perturbations associated with mantle upwelling exert first-order control on strain localization, crustal thinning, and the transition toward continental breakup or rift failure. Allowing plate motion to emerge from internal force balance, rather than prescribing kinematic boundary conditions, provides a physically consistent framework for investigating these interactions. Time-dependent changes in far-field driving stresses and mantle plume activity can modify the mechanical state of the lithosphere and extension velocities, influencing whether a rift matures into a plate boundary …

Positive Youth Development In Practice: National, Systematic, And Community-Level Insights Into Youth Empowerment And Behavioral Outcomes, Pamela Nicole Graham

Electronic Theses and Dissertations Archive

Behavioral outcomes in adolescents and youth reflect broader patterns of mental health and community support. Violent behaviors, substance misuse, and poor mental health disproportionately impact those living with unmet needs in settings concentrated with structural marginalization. These contexts often limit youths’ access to supportive systems that improve their alignment with prosocial outcomes. Local agencies and governments could encourage empowerment based programming to promote healthier developmental trajectories. This dissertation applies the Positive Youth Development (PYD) framework, integrated with Social Disorganization and Social Control theories, to examine how youth empowerment programs moderate the relationship between youths’ structural contexts and their subsequent developmental …

Effects Of Personalization On Student Retention In Online Data Science Learning, Farshid Farzan

Electronic Theses and Dissertations Archive

The present study examined whether static personalization strategies can reduce dropout in short-duration online data science learning. Using a 2 × 2 factorial design, 98 undergraduate participants completed an online learning activity that either (a) aligned instructional materials with their learning preference (sequential vs. global) or (b) included a personalized non-interactive pedagogical agent. Retention was operationalized dichotomously (completion vs. dropout). Logistic regression analyses indicated that learning preference personalization significantly increased the odds of completion, whereas the pedagogical agent alone did not show a reliable main effect. However, the interaction between learning preference personalization and agent presence was statistically significant, suggesting …

Ryan Anthony And The Concerto For Hope: An Application Of Symbolism And Performance Guide To The Third Trumpet Concerto By James Stephenson, Brandon Tyler Helms

Electronic Theses and Dissertations Archive

This study is a performance guide to Concerto for Trumpet #3 – Concerto for Hope by James Stephenson. Biographical information on James Stephenson and Ryan Anthony, the subject of the concerto, is also provided. It examines the work for trumpet, its origin, symbolism, compositional approach, elements of theoretical analysis, and proper application of style based on the subject matter. Pedagogical advice is also provided throughout the guide to help musicians preparing this piece prepare efficiently and effectively for a successful performance. Additional material is provided discussing differences between ensemble instrumentations, as well as performance suggestions regarding antiphonal instruments as they …

Asymmetrical S-Curve For Residual Load Sways Suppression For Double-Pendulum Rotary Crane Using Bayesian Optimization, Haryson Johanes Nyobuya

Tanzania Journal of Science

In rotary crane operations, one of the main difficulties lies in suppressing the load sway during its movement. This can be achieved using only horizontal boom motion, offering a solution that is energy-saving, simple, and safe. However, this approach renders the system under actuated, making the suppression objective more difficult to achieve. In this study, a double-pendulum model is adopted to capture the coupled dynamics of the suspended load and hook, which shows a realistic basis for sway suppression. An asymmetric S-curve velocity trajectory is proposed to shape the horizontal boom motion, effectively minimizing residual vibrations without requiring direct sway …

2026 April 2 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Quantitative Analysis Of Cholera Dynamics And The Impact Of Integrated Control Measures., Kazeem Abidoye Odeyemi, Mutairu Kayode Kolawole

Tanzania Journal of Science

A comprehensive mathematical evaluation of cholera dynamics, emphasizing the crucial role of optimal control strategies which include vaccination, treatment in endemic region and environmental hygiene in controlling the disease spread in Western and Mid-Eastern regions of African setting. Through analysis of the local and global stability of the model and assessing the reproduction number (��0), this research highlights how targeted interventions can influence transmission rates of cholera disease. Sensitivity analysis identifies key parameters driving cholera dynamics, underlining the urgency of timely and adequate intervention. Utilizing the innovative Homotopy Perturbation Method for the numerical simulation, the study explores the interplay between …

Theory And Applications Of Natural And Nature-Based Solutions In Estuarine Environments, Elizabeth L. Royer

USF Tampa Graduate Theses and Dissertations

This dissertation focuses on the theory and application of Nature-based Solutions (NbS), through three unique case studies. This study explores how the broad and interdisciplinary NbS framework can be applied to mitigate common coastal hazards. This framework considers the environment, economics, and social wellbeing, equally in the design and implementation of a solution. The current paradigm, working against nature, which is commonly seen in more passive approaches to hazard mitigation, like grey infrastructure (e.g. a seawall to protect a shoreline against wave action) does not accommodate the extremely dynamic environment. As perspectives shift to “working with nature” NbS can be …

Re: Conditional Approval Letter For Revised Clark Tailings Consolidated Waste Management Area (Ctcwma) Site Investigation Data Summary Report 2024 And Response To Epa Comment Letter (Dated February 24, 2026), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Effects Of Static Ankle Stretching On Balance And Gait: The Roles Of Age And Parkinson's Disease, Taylor M. Gauss

LSU Doctoral Dissertations

The focus of this dissertation involves the effects of static ankle stretching on balance and gait in adults of different ages and with Parkinson’s disease (PD). A brief introduction in Chapter 1 precedes a detailed literature review in Chapter 2, in which we identify gaps in research on balance and gait following ankle stretching and explain why ankle stretching may serve as a predominant strategy for improving motor performance in aging and PD populations. In Chapter 3, we present the first study identifying whether muscle group selection or stretch duration influences balance in young adults. Results showed that longer durations …

April 2, 2026, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

April 2, 2026, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Ais26s: Genai And Llms For Cybersecurity, Political Sciences, Transportation Security, And Resiliency, Latifur Khan

Paul English Applied Artificial Intelligence (AI) Institute Publications

This presentation examines the role of generative artificial intelligence (GenAI) and large language models (LLMs) in addressing complex challenges across cybersecurity, political science, and transportation security. Dr. Latifur Khan discusses how advanced AI methods can be applied to threat detection, data analysis, and decision-making in high-risk and data-intensive environments. The talk highlights interdisciplinary applications of LLMs, emphasizing their ability to extract insights from large-scale data, improve system resilience, and support intelligent infrastructure. Emerging research directions and practical implications for real-world deployment are also discussed.

Exploring The Well-Being Of Students: Mental Health Symptoms And Help-Seeking In Students With And Without Disabilities, Delaney M. Havrylkoff

LSU Master's Theses

Students with learning-related disabilities (LRDs) are a growing population in schools worthy of more holistic attention. This vulnerable population often receives support for their academic needs, while their mental health needs tend to get overlooked or untreated. Students with LRDs often face more negative experiences (e.g., lower academic performance, bullying, and peer victimization) in school compared to their peers without disabilities. As a result, they may experience higher levels of mental health issues. The purpose of this study was to examine the mental health status and service utilization of students with LRDs in schools compared to their peers without disabilities. …

Implementation Of Differentation Learning Based On Vark Learning Styles To Improve Dance Element Learning Outcomes Of Grade Vii Students, Bilqis Zainab Mujahidah, Agus Budiman, Beben Barnas

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The low learning outcomes of grade VII students in the three domains in learning dance elements are one of them due to the dominance of conventional methods. This type of research is Kemmis and McTaggart Class Action Research (CAR) which consists of planning, implementation of actions, observation, and reflection. The research ran for two cycles with the subjects of grade VII students of SMPN 14 Bandung City for the 2025/2026 school year. Data collection techniques through observation and learning outcome tests. Data analysis used descriptive statistics in the form of average values and classical completeness. The application of VARK-based differentiation …

Locating Vehicles Within Parking Facilities, Daniel Adam

Defensive Publications Series

This document describes a computing device (e.g., processing service, mobile phone, wearable device, smart device, vehicle, etc.) that aids in vehicle retrieval by collecting inertial, visual, and environmental data to guide a user to a parked vehicle within complex, multi-level parking structures. For instance, the computing device may utilize a multi-sensor fusion approach to integrate data from mobile computing device components such as barometric sensors, tilt sensors, accelerometers, gyroscopes, cameras, etc., and data from additional computing devices such as cameras, vehicles, charging ports, barriers, etc., to determine parked locations of vehicles. Further, the computing device may utilize the multi-sensor fusion …

Telemetry And Identity Chip Passport Protocol For Modular Storage Devices, N/A

Defensive Publications Series

This disclosure describes a telemetry and identity architecture for storage devices designed to facilitate hardware modularity, component-level flexibility, and streamlined data recovery. By decoupling a logic controller from the storage media and utilizing a dedicated non-volatile chip on the media module, the system enables seamless pairing and replacement of hardware components without the risk of data corruption. This dedicated chip functions as a hardware abstraction layer, storing specific metadata that allows a logic module to adopt and operate the media by understanding its unique physical characteristics. The architecture ensures data integrity and accessibility through a secure communication protocol and persistent …

Multi-Sense Point Voltage Adaptive Clocking Element, N/A

Defensive Publications Series

This disclosure describes a clocking system configured to dynamically adjust clock frequency in response to localized and global voltage variations across an integrated circuit die. The system employs multiple sensing points distributed across various regions of a semiconductor device to monitor supply voltage levels with low latency. By processing digitized data from these multiple sensors through look-up tables that characterize voltage-to-frequency relationships, the system identifies the most restrictive operating conditions. A centralized clocking element then adapts the output frequency to ensure stable operation even during rapid, high-slew-rate voltage droops. This proactive management allows for higher performance by reducing the need …

Redundant Relay Configuration For Safety And Isolation In High-Voltage Power Distribution Systems, N/A

Defensive Publications Series

The present disclosure describes a system and method for implementing safety redundancy in high-voltage direct current power distribution units using a master-slave relay configuration. By placing a master relay at the input of a power distribution unit, ahead of secondary relays and protective fuses, the system can independently isolate a single damaged unit without requiring a total system shutdown. The master relay typically remains in a closed state during normal operation and is commanded to open only when a fault, such as contact welding, is detected in the secondary relay. This approach mitigates the risks associated with inrush currents and …

System And Method For Network Infrastructure Asset Management And Supply Chain Orchestration, N/A

Defensive Publications Series

This publication describes systems and methods for managing supply chain operations and asset lifecycles within large-scale network infrastructures. The approach utilizes a layered software architecture to decouple supply chain planning from execution processes, enabling scalable and high-velocity hardware deployments. Hardware systems ordered as top-level assemblies are tracked and capitalized at the component level to facilitate accurate financial reporting, equipment upgrades, and decommissioning. Data from bill of materials services, procurement tracking platforms, and logistics proxies are aggregated to reconcile active network devices with their corresponding enterprise financial records.

Keywords: supply chain orchestration, asset management, network infrastructure, component reconciliation, top-level assemblies, …

Artificial Intelligence-Assisted Physical Design Convergence Cockpit, N/A

Defensive Publications Series

The design of modern semiconductors face challenges with numerous parallel place and route runs triggered by continuous updates, which are utilized to achieve quality of results and power, performance, and area convergence. The described technology introduces an artificial intelligence-assisted physical design convergence cockpit, which operates as a multi-agent system powered by large language models and retrieval-augmented generation engines. This system acts as an autonomous orchestrator that monitors design repositories, intelligently launches and tracks electronic design automation flows, performs real-time failure triage by parsing log files, and executes self-healing design closures by generating corrective scripts. The system features a modular architecture …

Symmetry-Aware Optimization Framework For Network Topology And Collective Algorithm Co-Design, N/A

Defensive Publications Series

The technology relates to a software framework providing for the simultaneous co-design of network topologies and collective communication algorithms in distributed computing environments. The software framework utilizes a graph-theory-based model to represent computing nodes and physical communication links, encoding hardware and software parameters into a solver-readable mathematical formulation. By applying combinatorial optimization solvers, the software framework identifies highly efficient physical cabling schemas and corresponding algorithmic routing schedules. To handle highly complex search spaces, the approach leverages graph automorphisms and symmetries in collective operations to significantly reduce the combinatorial search space. This enables the generation of tailored interconnect architectures and message-passing …

System And Method For Dynamic Material Delivery Scheduling Via Asynchronous Constraint Resolution, N/A

Defensive Publications Series

This publication describes a technology for managing supply chain material delivery schedules through asynchronous constraint resolution. The system replaces static delivery dates with dynamic calculations based on real-time event signals. An event ingestion layer receives updates from non-logistics systems, such as site readiness tools and workforce management databases. A central logic engine evaluates these signals against a hierarchical priority logic to throttle warehouse execution at an individual line-item level. When constraints clear, the system automatically triggers a global re-optimization of the delivery schedule to synchronize material arrivals with available resources.

Keywords: dynamic scheduling, asynchronous constraint resolution, supply chain management, …

Systems And Methods For Repairability-Driven Error Detection And Mitigation, N/A

Defensive Publications Series

This publication discloses systems and methods for enhancing computing hardware reliability through repairability-driven error detection. Upper-layer software components select a minimum repair action to address hardware or low-level software errors. Each error type is associated with a tagged minimum repair action, which may be determined statically or dynamically at runtime. Machine learning models or expert inputs can be utilized to derive the tagged repair actions based on historical error logs and remediation probabilities. Additional environmental or diagnostic conditions may guide the selection of a specific repair action. The system evaluates both the execution time and the diagnostic time to select …

Universal Power Summer For Low-Voltage Direct Current Power Distribution, N/A

Defensive Publications Series

A low-voltage direct current power distribution system pools power from multiple direct current inputs simultaneously into a single output using solid-state components. The system utilizes silicon carbide metal-oxide-semiconductor field-effect transistors configured as active diodes to sum independent direct current power sources, enabling configurable redundancy models at the load level. If an upstream power source experiences a fault, the system detects reverse current flow and isolates the fault in microseconds. This approach allows load balancing through resistive droop sharing and provides uninterrupted power delivery without switching transients.

Keywords: low-voltage direct current, universal power summer, silicon carbide, active diode, resistive droop …

Embedded Components In Printed Circuit Board Cavities, Na

Defensive Publications Series

This publication details structural configurations for embedding components within printed circuit board cavities. As printed circuit boards are designed with increased thickness, incorporating recessed cavities allows for heterogeneous layers that accommodate components across multiple different levels. The described structures open possibilities for advanced cooling designs, improved signal integrity, reduced vertical height, and decreased material weight. For example, embedded cold plates can reside within these cavities to provide effective thermal management for components located on the opposite side of the board. Furthermore, vertical power modules or capacitors can be embedded into cavities directly opposite to an application-specific integrated circuit to shorten …

Hybrid Mesh-Grid Clock Design For Low Latency And Low On-Chip-Variation, N/A

Defensive Publications Series

The technology described in this paper relates to a hybrid spine-mesh clock distribution network configured to deliver high-frequency clock signals across a network-on-chip fabric in a system-on-chip architecture. The network minimizes clock latency, clock skew, and the overall impact of on-chip variation. The network combines spine-based distribution structures with a grid-like mesh topology. Main spines route the clock signal in a primary direction using upper metal layers while distributed trees or sub-grids branch orthogonally to deliver the clock signal to localized functional areas. A final stage mesh connects to local sequential elements, providing multiple propagation paths that average out localized …