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Articles 237241 - 237270 of 1825439
Full-Text Articles in Entire DC Network
Constrained Reinforcement Learning In Hard Exploration Problems, Pankayaraj Pathmanathan, Pradeep Varakantham
Constrained Reinforcement Learning In Hard Exploration Problems, Pankayaraj Pathmanathan, Pradeep Varakantham
Research Collection School Of Computing and Information Systems
One approach to guaranteeing safety in Reinforcement Learning is through cost constraints that are imposed on trajectories. Recent works in constrained RL have developed methods that ensure constraints can be enforced even at learning time while maximizing the overall value of the policy. Unfortunately, as demonstrated in our experimental results, such approaches do not perform well on complex multi-level tasks, with longer episode lengths or sparse rewards. To that end, wepropose a scalable hierarchical approach for constrained RL problems that employs backward cost value functions in the context of task hierarchy and a novel intrinsic reward function in lower levels …
Future Aware Pricing And Matching For Sustainable On-Demand Ride Pooling, Xianjie Zhang, Pradeep Varakantham, Hao Jiang
Future Aware Pricing And Matching For Sustainable On-Demand Ride Pooling, Xianjie Zhang, Pradeep Varakantham, Hao Jiang
Research Collection School Of Computing and Information Systems
The popularity of on-demand ride pooling is owing to the benefits offered to customers (lower prices), taxi drivers (higher revenue), environment (lower carbon footprint due to fewer vehicles) and aggregation companies like Uber (higher revenue). To achieve these benefits, two key interlinked challenges have to be solved effectively: (a) pricing – setting prices to customer requests for taxis; and (b) matching – assignment of customers (that accepted the prices) to taxis/cars. Traditionally, both these challenges have been studied individually and using myopic approaches (considering only current requests), without considering the impact of current matching on addressing future requests. In this …
An Empirical Study Of Package Management Issues Via Stack Overflow, Syful Islam, Raula Kula, Christoph Treude, Bodin Chinthanet, Takashi Ishio, Kenichi Matsumoto
An Empirical Study Of Package Management Issues Via Stack Overflow, Syful Islam, Raula Kula, Christoph Treude, Bodin Chinthanet, Takashi Ishio, Kenichi Matsumoto
Research Collection School Of Computing and Information Systems
The package manager (PM) is crucial to most technology stacks, acting as a broker to ensure that a verified dependency package is correctly installed, configured, or removed from an application. Diversity in technology stacks has led to dozens of PMs with various features. While our recent study indicates that package management features of PM are related to end-user experiences, it is unclear what those issues are and what information is required to resolve them. In this paper, we have investigated PM issues faced by end-users through an empirical study of content on Stack Overflow (SO). We carried out a qualitative …
Bidding Graph Games With Partially-Observable Budgets, Guy Avni, Ismael Jecker, Dorde Zikelic
Bidding Graph Games With Partially-Observable Budgets, Guy Avni, Ismael Jecker, Dorde Zikelic
Research Collection School Of Computing and Information Systems
Two-player zero-sum graph games are a central model, which proceeds as follows. A token is placed on a vertex of a graph, and the two players move it to produce an infinite play, which determines the winner or payoff of the game. Traditionally, the players alternate turns in moving the token. In bidding games, however, the players have budgets and in each turn, an auction (bidding) determines which player moves the token. So far, bidding games have only been studied as fullinformation games. In this work we initiate the study of partial-information bidding games: we study bidding games in which …
Learning Control Policies For Stochastic Systems With Reach-Avoid Guarantees, Dorde Zikelic, Mathias Lechner, A. Thomas Henzinger, Krishnendu Chatterjee
Learning Control Policies For Stochastic Systems With Reach-Avoid Guarantees, Dorde Zikelic, Mathias Lechner, A. Thomas Henzinger, Krishnendu Chatterjee
Research Collection School Of Computing and Information Systems
We study the problem of learning controllers for discrete-time non-linear stochastic dynamical systems with formal reach-avoid guarantees. This work presents the first method for providing formal reach-avoid guarantees, which combine and generalize stability and safety guarantees, with a tolerable probability threshold p ∈ [0,1] over the infinite time horizon in general Lipschitz continuous systems. Our method leverages advances in machine learning literature and it represents formal certificates as neural networks. In particular, we learn a certificate in the form of a reach-avoid supermartingale (RASM), a novel notion that we introduce in this work. Our RASMs provide reachability and avoidance guarantees …
Safe Delivery Of Critical Services In Areas With Volatile Security Situation Via A Stackelberg Game Approach, Tien Mai, Arunesh Sinha
Safe Delivery Of Critical Services In Areas With Volatile Security Situation Via A Stackelberg Game Approach, Tien Mai, Arunesh Sinha
Research Collection School Of Computing and Information Systems
Vaccine delivery in under-resourced locations with security risks is not just challenging but also life threatening. The COVID pandemic and the need to vaccinate added even more urgency to this issue. Motivated by this problem, we propose a general framework to set-up limited temporary (vaccination) centers that balance physical security and desired (vaccine) service coverage with limited resources. We set-up the problem as a Stackelberg game between the centers operator (defender) and an adversary, where the set of centers is not fixed a priori but is part of the decision output. This results in a mixed combinatorial and continuous optimization …
An Enhanced Cloud-Native Deep Learning Pipeline For The Classification Of Network Traffic, Ahmed Sobhy Elkenawy
An Enhanced Cloud-Native Deep Learning Pipeline For The Classification Of Network Traffic, Ahmed Sobhy Elkenawy
Theses and Dissertations
In a rapidly changing world, the way of solving real-world problems has changed to leverage the power of the advancements in multiple fields. Cloud-native computing approaches can be utilized with deep learning techniques to provide solutions in several important areas. For instance, with the emergence of the pandemic, much dependence on modern technologies came out as a replacement for face-to-face interaction. Deep learning can reach a high level of accuracy, which makes it very effective in the support of modern services and technologies. However, there are some challenging issues because deep learning requires many large-scale experiments, which demand a lot …
Utilizing Design Thinking To Enhance Wellbeing In Interdisciplinary Courses: A Positive Social Psychology Approach, Areej Elsayary
Utilizing Design Thinking To Enhance Wellbeing In Interdisciplinary Courses: A Positive Social Psychology Approach, Areej Elsayary
All Works
Design thinking is considered to be a positive social psychology intervention. Students who practice using the design thinking process during their coursework will most likely solve personal problems that improve their well-being. This study investigates the impact of using the design thinking process in interdisciplinary courses to enhance students' well-being through developing mindsets that enable them to solve their problems and set personal goals unconsciously. A modified PERMA-PH model is used to guide this study. The PERMA included Positive Emotions, Negative Emotions, Engagement, Relationship, Meaning and Purpose, and Accomplishments, the "PH" (future plans and health) was added to the PE …
Engineering A Microbiosphere To Clean Up The Ocean – Inspiration From The Plastisphere, Khulood A. Alnahdi, Laila W. Alali, Mezna K. Suwaidan, M. Kalim Akhtar
Engineering A Microbiosphere To Clean Up The Ocean – Inspiration From The Plastisphere, Khulood A. Alnahdi, Laila W. Alali, Mezna K. Suwaidan, M. Kalim Akhtar
All Works
Plastic is a ubiquitous material that has become an essential part of our lives. More than one hundred million tons of plastic has accumulated in the world’s oceans as a result of poor waste management. This plastic waste gradually fragments into smaller pieces known as microplastics and nanoplastics. These small plastic particles can cause significant damage to marine ecosystems, and negatively impact human health. According to a recent review of international patents, the majority of ocean-cleaning inventions are limited to microplastics larger than 20 μm. Furthermore, such technologies are ineffective for nanoplastics, which measure less than 1000 nm, or even …
Carla+: An Evolution Of The Carla Simulator For Complex Environment Using A Probabilistic Graphical Model, Sumbal Malik, Manzoor Ahmed Khan, Aadam, Hesham El-Sayed, Farkhund Iqbal, Jalal Khan, Obaid Ullah
Carla+: An Evolution Of The Carla Simulator For Complex Environment Using A Probabilistic Graphical Model, Sumbal Malik, Manzoor Ahmed Khan, Aadam, Hesham El-Sayed, Farkhund Iqbal, Jalal Khan, Obaid Ullah
All Works
In an urban and uncontrolled environment, the presence of mixed traffic of autonomous vehicles, classical vehicles, vulnerable road users, e.g., pedestrians, and unprecedented dynamic events makes it challenging for the classical autonomous vehicle to navigate the traffic safely. Therefore, the realization of collaborative autonomous driving has the potential to improve road safety and traffic efficiency. However, an obvious challenge in this regard is how to define, model, and simulate the environment that captures the dynamics of a complex and urban environment. Therefore, in this research, we first define the dynamics of the envisioned environment, where we capture the dynamics relevant …
Independent Analysis And Interpretation Of The New Mexico Constitution: If Not Now, When?, The Honorable Linda M. Vanzi, Mark T. Baker
Independent Analysis And Interpretation Of The New Mexico Constitution: If Not Now, When?, The Honorable Linda M. Vanzi, Mark T. Baker
New Mexico Law Review
This article posits that the mode of analysis of state constitutional issues adopted by the New Mexico Supreme Court in State v. Gomez, as it has been applied in the civil context, has neither “promote[d] the development of a sound body of state constitutional jurisprudence” nor led to “consistent, predictable, and reasonable state court decision-making,” as some envisioned in 1998. Instead, it has often led to essentially automatic deference to federal precedent interpreting comparable provisions of the Federal Constitution and very limited, if any, consideration of protections afforded under our state constitution. In addition, the inconsistent application of the Gomez …
Negligent Commercial Transactions: Does New Mexico Face A Slippery Slope After Morris?, Annika Cleveland
Negligent Commercial Transactions: Does New Mexico Face A Slippery Slope After Morris?, Annika Cleveland
New Mexico Law Review
In its July 2021 decision, Morris v. Giant Four Corners, the New Mexico Supreme Court held that the doctrine of negligent entrustment includes liability for someone who supplies gasoline to a person they knew or should have known was intoxicated. While the Morris court’s decision is novel in New Mexico, courts will likely interpret the inclusion narrowly, restricting the duty to circumstances where a commercial transaction enabled a DWI. By reviewing the decisions of other jurisdictions to include certain commercial transactions under negligent entrustment claims and the impact those decisions had on subsequent litigation, this article argues that Morris will …
Wallaby Pilot Survey: H I Gas Kinematics Of Galaxy Pairs In Cluster Environment, Shin-Jeong Kim, Se-Heon Oh, Jing Wang, Lister Staveley-Smith, Bärbel S. Koribalski, Minsu Kim, Hye-Jin Park, Shinna Kim, Kristine Spekkens, Juan P. Madrid
Wallaby Pilot Survey: H I Gas Kinematics Of Galaxy Pairs In Cluster Environment, Shin-Jeong Kim, Se-Heon Oh, Jing Wang, Lister Staveley-Smith, Bärbel S. Koribalski, Minsu Kim, Hye-Jin Park, Shinna Kim, Kristine Spekkens, Juan P. Madrid
Physics & Astronomy Faculty Publications
We examine the H I gas kinematics of galaxy pairs in two clusters and a group using Australian Square Kilometre Array Pathfinder (ASKAP) WALLABY pilot survey observations. We compare the H I properties of galaxy pair candidates in the Hydra I and Norma clusters, and the NGC 4636 group, with those of non-paired control galaxies selected in the same fields. We perform H I profile decomposition of the sample galaxies using a tool, BAYGAUD, which allows us to deblend a line-of-sight velocity profile with an optimal number of Gaussian components. We construct H I superprofiles of the sample galaxies via …
Enhanced Two-Step Deep-Learning Approach For Electromagnetic-Inverse-Scattering Problems: Frequency Extrapolation And Scatterer Reconstruction, Huan Huan Zhang, He Ming Yao, Lijun Jiang, Michael Ng
Enhanced Two-Step Deep-Learning Approach For Electromagnetic-Inverse-Scattering Problems: Frequency Extrapolation And Scatterer Reconstruction, Huan Huan Zhang, He Ming Yao, Lijun Jiang, Michael Ng
Electrical and Computer Engineering Faculty Research & Creative Works
The electromagnetic-inverse-scattering (EMIS) problem is solved by a novel two-step deep-learning (DL) approach in this article. The newly proposed two-step DL approach not only predicts the multifrequency EM scattered field, but also overcomes the limitation of the conventional methods for solving EMIS problems, such as expensive computational cost, strong ill-conditions, and invalidity on high contrast. In the first step, the complex-valued deep residual convolutional neural network (DRCNN) is utilized to predict multifrequency EM scattered fields only using single-frequency EM scattered field information. Based on a new complex-valued deep convolutional encoder-decoder (DCED) structure, the second step utilizes the obtained multifrequency EM …
An Evaluation Of Avian Influenza Virus Whole-Genome Sequencing Approaches Using Nanopore Technology, Hon S. Ip, Sarah Uhm, Mary Lea Killian, Mia K. Torchetti
An Evaluation Of Avian Influenza Virus Whole-Genome Sequencing Approaches Using Nanopore Technology, Hon S. Ip, Sarah Uhm, Mary Lea Killian, Mia K. Torchetti
United States Department of Agriculture Wildlife Services: Staff Publications
As exemplified by the global response to the SARS-CoV-2 pandemic, whole-genome sequencing played an important role in monitoring the evolution of novel viral variants and provided guidance on potential antiviral treatments. The recent rapid and extensive introduction and spread of highly pathogenic avian influenza virus in Europe, North America, and elsewhere raises the need for similarly rapid sequencing to aid in appropriate response and mitigation activities. To facilitate this objective, we investigate a next-generation sequencing platform that uses a portable nanopore sequencing device to generate and present data in real time. This platform offers the potential to extend in-house sequencing …
The Effect Of An American Heart Association–Approved Exercise Regimen On Burnout In Nurse Practitioners And Physician Assistants Working In Emergency Departments, Michelle Lee Johnson
The Effect Of An American Heart Association–Approved Exercise Regimen On Burnout In Nurse Practitioners And Physician Assistants Working In Emergency Departments, Michelle Lee Johnson
Electronic Theses and Dissertations
Burnout is a widely known state of physical and emotional fatigue previously noted to affect as many as 60% of healthcare providers, but one that is understudied in nurse practitioners and physician assistants working in emergency departments. It is imperative that the providers of healthcare recognize in themselves signs of burnout and have resources available to mitigate the condition. A pretest–posttest, quasi-experimental, nonequivalent control group, descriptive research design with descriptive statistics analysis was used to analyze answers to an email-based survey sent to nurse practitioners and physician assistants working for one large emergency medicine staffing company. The intent of this …
Mindfulness Based Stress Reduction Techniques In Chronic Illness, Anna Celia Gil
Mindfulness Based Stress Reduction Techniques In Chronic Illness, Anna Celia Gil
Electronic Theses and Dissertations
Abstract
Chronic stress and its effect on both physical and mental health have been a topic of increasing interest in the past several decades. There is mounting evidence that recurrent, persistent stress of both a physiologic and psychological nature leads to a dysfunction in the hypothalamic pituitary axis (HPA), the system which helps the body recover and adapt to short term stress. In long term stress, this HPA dysfunction leads to impairment of the immune and neuroendocrine systems resulting in chronic low-grade inflammation. This type of chronic inflammation acts as a precursor to several chronic illnesses such as diabetes, hypertension, …
Female Ex-Offenders Transitioning Into Society, Stacey L. Forte
Female Ex-Offenders Transitioning Into Society, Stacey L. Forte
Electronic Theses and Dissertations
The purpose of this qualitative study was to examine female ex-offenders’ perceptions of their lived experience(s) while transitioning into society after incarceration. This study examined risk factors that female ex-offenders faced while transitioning into society asking the question, “What are the lived experiences of female ex-offenders who utilized transitional housing for reentry with regard to their perception of the benefits of certain services/offerings and staff support?” Nine participants were part of the study ranging from 25–64 years of age, with the majority being between the ages of 25 and 55 years old, residing originally in five different states. Sixty percent …
On Viscoelastic Fiber Jet Formation By Forcespinning At High Rotation Rate, Daniel N. Riahi, Saulo Orizaga
On Viscoelastic Fiber Jet Formation By Forcespinning At High Rotation Rate, Daniel N. Riahi, Saulo Orizaga
School of Mathematical & Statistical Sciences Faculty Publications
We consider a nonlinear three-dimensional viscoelastic fiber jet that is generated during a forcespinning process. We provide a particular case for such a rotating jet at a high rotation rate. We use a viscoelastic constitutive model for the jet equations and then applying a new slender body approach, we continue with proper scaling and perturbation technique to develop a new model for such a jet system. We find that the profiles for jet quantities versus arc length are notably different from all those in related studies reported before for either high or low rotation rates. In particular, jet radius first …
World Transit Research February 2023 Newsletter, Institute Of Transport Studies Monash University
World Transit Research February 2023 Newsletter, Institute Of Transport Studies Monash University
World Transit Research Newsletter
No abstract provided.
A Corpus-Driven Comparative Analysis Of Verb Phrase Based Bundles In L2 Malaysian Polytechnic Learners’ Writing, Subramaniam Radika
A Corpus-Driven Comparative Analysis Of Verb Phrase Based Bundles In L2 Malaysian Polytechnic Learners’ Writing, Subramaniam Radika
Student Works (2020-2029)
This study aims to explore the similarities and differences in the use of verb phrase-based (VP-based) bundles in the writing of L2 Malaysian Engineering learners via the Malaysian Polytechnic Electronic Engineering Learner Corpus (MyPolyEELC) in comparison to their native counterparts in the British Academic Written English (BAWE) sub-corpus and experts in the Electrical and Electronic Engineering Research Articles Corpus (3ERAC). The MyPolyEELC which consists of 891,919 words is developed from 231 Final Year Project reports written by Electronic Engineering Diploma learners from 14 Malaysian polytechnics. The 374,383-word BAWE sub-corpus is compiled from the existing BAWE corpus by selecting texts written …
Effective Farm Management Promotes Native Amf And Benefit Organic Farming Systems, Pushpa Soti, Rupesh R. Kariyat, Alexis Racelis
Effective Farm Management Promotes Native Amf And Benefit Organic Farming Systems, Pushpa Soti, Rupesh R. Kariyat, Alexis Racelis
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Highlights
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Agricultural practices have significant influence on the AMF community dynamics.
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Soil nutrients regulate AMF spore abundance and diversity.
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Using grass cover crops can promote native AMF in farms.
Abstract
Using soil inoculants containing naturally occurring beneficial microorganisms has become a popular practice in sustainable agriculture. However, an understanding of the environmental variables that affect plant-microbe interactions and the benefit of using commercial inoculum is relatively sparse. To address this, we examined the efficiency of three different methods to inoculate AMF (Arbuscular Mycorrhizal Fungi) in organic vegetable farms in south Texas: cover cropping, application of farm-produced (indigenous) AMF inoculum, …
Combinatorial Identities Associated With A Bivariate Generating Function For Overpartition Pairs, Atul Dixit, Ankush Goswami
Combinatorial Identities Associated With A Bivariate Generating Function For Overpartition Pairs, Atul Dixit, Ankush Goswami
School of Mathematical & Statistical Sciences Faculty Publications
We obtain a three-parameter q-series identity that generalizes two results of Chan and Mao. By specializing our identity, we derive new results of combinatorial significance in connection with N(r,s,m,n), a function counting certain overpartition pairs recently introduced by Bringmann, Lovejoy and Osburn. For example, one of our identities gives a closed-form evaluation of a double series in terms of Chebyshev polynomials of the second kind, thereby resulting in an analogue of Euler's pentagonal number theorem. Another of our results expresses a multi-sum involving N(r,s,m,n) in terms of just the partition function p(n). Using a result of Shimura we also relate …
Coloring Complexes And Combinatorial Hopf Monoids, Jacob A. White
Coloring Complexes And Combinatorial Hopf Monoids, Jacob A. White
School of Mathematical & Statistical Sciences Faculty Publications
We generalize the notion of a coloring complex of a graph to linearized combinatorial Hopf monoids. We determine when a linearized combinatorial Hopf monoid has such a construction, and discover some inequalities that are satisfied by the quasisymmetric function invariants associated to the combinatorial Hopf monoid. We show that the collection of all such coloring complexes forms a linearized combinatorial Hopf monoid, which is the terminal object in the category of combinatorial Hopf monoids with convex characters. We also study several examples of combinatorial Hopf monoids.
Patient-Mediated Interventions In Hospital: A Systematic Review, Georgia Tobiano, Shelley Roberts, Rachel Muir, Teresa Jerofke-Owen, Christine Ting, Sarah Thorning, Daren K. Heyland, Andrea P. Marshall
Patient-Mediated Interventions In Hospital: A Systematic Review, Georgia Tobiano, Shelley Roberts, Rachel Muir, Teresa Jerofke-Owen, Christine Ting, Sarah Thorning, Daren K. Heyland, Andrea P. Marshall
College of Nursing Faculty Research and Publications
Aims
To describe the characteristics of hospital-based, patient-mediated interventions and their impact on patient, clinician and organization outcomes.
Design
Systematic review.
Data Sources
Health literature databases (MEDLINE, CINAHL and EMBASE) were searched in August 2021. Backward and forward citation searching was conducted.
Review Methods
Studies investigating patient-mediated interventions, targeted at adult hospitalized patients were eligible. Data were extracted related to study and intervention characteristics. Narrative synthesis was used to understand intervention impact on patient, clinician and organization outcomes (as per a framework). Methodological quality was assessed using the Mixed Methods Assessment Tool.
Results
Thirty-three studies, reporting 18 interventions, were included. …
Missed Opportunities In The Diagnosis Of Tuberculosis Meningitis, Niamh Simmons, Margaret A Olsen, Joanna Buss, Thomas C Bailey, Carlos Mejia-Chew
Missed Opportunities In The Diagnosis Of Tuberculosis Meningitis, Niamh Simmons, Margaret A Olsen, Joanna Buss, Thomas C Bailey, Carlos Mejia-Chew
2020-Current year OA Pubs
BACKGROUND: Tuberculosis meningitis (TBM) has high mortality and morbidity. Diagnostic delays can impact TBM outcomes. We aimed to estimate the number of potentially missed opportunities (MOs) to diagnose TBM and determine its impact on 90-day mortality.
METHODS: This is a retrospective cohort of adult patients with a central nervous system (CNS) TB
RESULTS: Of 893 patients with TBM, median age at diagnosis was 50 years (interquartile range, 37-64), 61.3% were male, and 35.2% had Medicaid as primary payer. Overall, 407 (45.6%) had a prior hospital or ED visit with an MO code. In-hospital 90-day mortality was not different between those …
The Bg News February 1, 2023, Bowling Green State University
The Bg News February 1, 2023, Bowling Green State University
BG News (Student Newspaper)
The BGSU campus student newspaper. February 01, 2023. Volume 102-Issue 16.
The Disembodied First Amendment, Nathan Cortez, William M. Sage
The Disembodied First Amendment, Nathan Cortez, William M. Sage
Faculty Scholarship
First Amendment doctrine is becoming disembodied—increasingly detached from human speakers and listeners. Corporations claim that their speech rights limit government regulation of everything from product labeling to marketing to ordinary business licensing. Courts extend protections to commercial speech that ordinarily extended only to core political and religious speech. And now, we are told, automated information generated for cryptocurrencies, robocalling, and social media bots are also protected speech under the Constitution. Where does it end? It begins, no doubt, with corporate and commercial speech. We show, however, that heightened protection for corporate and commercial speech is built on several “artifices” - …
Do We Need Patient-Specific Qa For Adaptively Generated Plans? Retrospective Evaluation Of Delivered Online Adaptive Treatment Plans On Varian Ethos, Xiaodong Zhao, Dennis N Stanley, Carlos E Cardenas, Joseph Harms, Richard A Popple
Do We Need Patient-Specific Qa For Adaptively Generated Plans? Retrospective Evaluation Of Delivered Online Adaptive Treatment Plans On Varian Ethos, Xiaodong Zhao, Dennis N Stanley, Carlos E Cardenas, Joseph Harms, Richard A Popple
2020-Current year OA Pubs
BACKGROUND: The clinical introduction of dedicated treatment units for online adaptive radiation therapy (OART) has led to widespread adoption of daily adaptive radiotherapy. OART allows for rapid generation of treatment plans using daily patient anatomy, potentially leading to reduction of treatment margins and increased normal tissue sparing. However, the OART workflow does not allow for measurement of patient-specific quality assurance (PSQA) during treatment delivery sessions and instead relies on secondary dose calculations for verification of adapted plans. It remains unknown if independent dose verification is a sufficient surrogate for PSQA measurements.
PURPOSE: To evaluate the plan quality of previously treated …
Lgmdd1 Natural History And Phenotypic Spectrum: Implications For Clinical Trials, Andrew R Findlay, Sarah E Robinson, Stephanie Poelker, Michelle Seiffert, Rocio Bengoechea, Conrad C Weihl
Lgmdd1 Natural History And Phenotypic Spectrum: Implications For Clinical Trials, Andrew R Findlay, Sarah E Robinson, Stephanie Poelker, Michelle Seiffert, Rocio Bengoechea, Conrad C Weihl
2020-Current year OA Pubs
OBJECTIVE: To delineate the full phenotypic spectrum and characterize the natural history of limb girdle muscular dystrophy type D1 (LGMDD1).
METHODS: We extracted age at clinical events of interest contributing to LGMDD1 disease burden via a systematic literature and chart review. Manual muscle testing and quantitative dynamometry data were used to estimate annualized rates of change. We also conducted a cross-sectional observational study using previously validated patient-reported outcome assessments (ACTIVLIM, PROMIS-57) and a new LGMDD1 questionnaire. Some individuals underwent repeat ACTIVLIM and LGMDD1 questionnaire assessments at 1.5 and 2.5 years.
RESULTS: A total of 122 LGMDD1 patients were included from …