Digital Commons Network^™

The Gdf15-Gfral Axis Mediates Chemotherapy-Induced Fatigue In Mice, Brandon Chelette, Chinenye L Chidomere, Robert Dantzer

Faculty, Staff and Student Publications

Cancer-related fatigue is defined as a distressing persistent subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and that interferes with usual functioning. This form of fatigue is highly prevalent during cancer treatment and in some patients, it can persist for years after treatment has ended. An understanding of the mechanisms that drive cancer-related fatigue is still lacking, which hampers the identification of effective treatment options. Various chemotherapeutic agents including cisplatin are known to induce mitochondrial dysfunction and this effect is known to mediate chemotherapy-induced peripheral …

Vip152 Is A Selective Cdk9 Inhibitor With Pre-Clinical In Vitro And In Vivo Efficacy In Chronic Lymphocytic Leukemia, Steven Sher, Ethan Whipp, Janek Walker, Pu Zhang, Larry Beaver, Katie Williams, Shelley Orwick, Janani Ravikrishnan, Brandi Walker, Elizabeth Perry, Charles Gregory, Matthew Purcell, Alexander Pan, Pearlly Yan, Lapo Alinari, Amy J Johnson, Melanie M Frigault, Joy M Greer, Ahmed Hamdy, Raquel Izumi, Xiaokui Mo, Deepa Sampath, Jennifer Woyach, James Blachly, John C Byrd, Rosa Lapalombella

Faculty, Staff and Student Publications

Chronic lymphocytic leukemia (CLL) is effectively treated with targeted therapies including Bruton tyrosine kinase inhibitors and BCL2 antagonists. When these become ineffective, treatment options are limited. Positive transcription elongation factor complex (P-TEFb), a heterodimeric protein complex composed of cyclin dependent kinase 9 (CDK9) and cyclin T1, functions to regulate short half-life transcripts by phosphorylation of RNA Polymerase II (POLII). These transcripts are frequently dysregulated in hematologic malignancies; however, therapies targeting inhibition of P-TEFb have not yet achieved approval for cancer treatment. VIP152 kinome profiling revealed CDK9 as the main enzyme inhibited at 100 nM, with over a 10-fold increase in …

Optimized Decision Support For Selection Of Transoral Robotic Surgery Or (Chemo)Radiation Therapy Based On Posttreatment Swallowing Toxicity, Mehdi Hemmati, Carly Barbon, Abdallah S R Mohamed, Lisanne V Van Dijk, Amy C Moreno, Neil D Gross, Ryan P Goepfert, Stephen Y Lai, Katherine A Hutcheson, Andrew J Schaefer, Clifton D Fuller, Md Anderson Head And Neck Cancer Symptom Working Group Affiliations Expand

Faculty, Staff and Student Publications

BACKGROUND: A primary goal in transoral robotic surgery (TORS) for oropharyngeal squamous cell cancer (OPSCC) survivors is to optimize swallowing function. However, the uncertainty in the outcomes of TORS including postoperative residual positive margin (PM) and extranodal extension (ENE), may necessitate adjuvant therapy, which may cause significant swallowing toxicity to survivors.

METHODS: A secondary analysis was performed on a prospective registry data with low- to intermediate-risk human papillomavirus-related OPSCC possibly resectable by TORS. Decision trees were developed to model the uncertainties in TORS compared with definitive radiation therapy (RT) and chemoradiation therapy (CRT). Swallowing toxicities were measured by Dynamic Imaging …

A Molecular Signature Defining Exercise Adaptation With Ageing And In Vivo Partial Reprogramming In Skeletal Muscle, Ronald G. Jones Iii, Andrea Dimet-Wiley, Amin Haghani, Francielly Morena Da Silva, Camille R. Brightwell, Seongkyun Lim, Sabin Khadgi, Yuan Wen, Corey M. Dungan, Robert T. Brooke, Nicholas P. Greene, Charlotte A. Peterson, John J. Mccarthy, Steve Horvath, Stanley J. Watowich, Christopher S. Fry, Kevin A. Murach

Health, Human Performance and Recreation Faculty Publications and Presentations

Exercise promotes functional improvements in aged tissues, but the extent to which it simulates partial molecular reprogramming is unknown. Using transcriptome profiling from (1) a skeletal muscle-specific in vivo Oct3/4, Klf4, Sox2 and Myc (OKSM) reprogramming-factor expression murine model; (2) an in vivo inducible muscle-specific Myc induction murine model; (3) a translatable high-volume hypertrophic exercise training approach in aged mice; and (4) human exercise muscle biopsies, we collectively defined exercise-induced genes that are common to partial reprogramming. Late-life exercise training lowered murine DNA methylation age according to several contemporary muscle-specific clocks. A comparison of the murine soleus transcriptome …

The Link Between Serum Omentin Level And Insulin Resistance Biomarkers, Lipid Profile, And Atherogenic Indices In Iraqi Obese Patients., Tahrir Etihad Kadium, Abdulhadi Alrubaie, Salim Abd Mohammed Ghanim

Baghdad Science Journal

Omentin (or intelectin) is a main visceral fat secretory adipokine. There is a growing interest to link omentin, obesity and co-morbidity factors. The aim of the present study is to evaluate serum omentin and its association to insulin resistance biomarkers, lipid profile and atherogenic indies. This cross – sectional study was conducted in Obesity Research and Therapy Unit-Alkindy College of Medicine by recruiting (115) individuals; 49 males /66 females. Subjects between (20 to 60) years of age were selected and classified into two groups according to their Body mass index (BMI). Group1 involved healthy lean volunteers (25 male/ 36 female; …

3-D Packing In Container Using Teaching Learning Based Optimization Algorithm, Linda Fitriyani, Larissa Alva Zerinda, Asri Bekti Pratiwi, Edi Winarko

Baghdad Science Journal

The paper aims to propose Teaching Learning based Optimization (TLBO) algorithm to solve 3-D packing problem in containers. The objective which can be presented in a mathematical model is optimizing the space usage in a container. Besides the interaction effect between students and teacher, this algorithm also observes the learning process between students in the classroom which does not need any control parameters. Thus, TLBO provides the teachers phase and students phase as its main updating process to find the best solution. More precisely, to validate the algorithm effectiveness, it was implemented in three sample cases. There was small data …

Synthesis, Characterization And Bioactivity Study From Azo – Ligand Derived Frommethyl-2-Amino Benzoatewith Some Metal Ions, Israa H. Ibraheem, Noora Saad Mubder, Mays Mohammed Abdullah, Haider Al-Neshmi

Baghdad Science Journal

A Ligand (ECA) methyl 2-((1-cyano-2-ethoxy-2-oxoethyl)diazenyl)benzoate with metals of (Co2+, Ni2+, Cu2+) were prepared and characterization using H-NMR, atomic absorption spectroscopy, ultra violet (UV) visible, magnetic moments measurements, bioactivity, and Molar conductivity measurements in soluble ethanol. Complexes have been prepared using a general formula which was suggested as [M (ECA)2] Cl2, where M = (Cobalt(II), Nickel(II) and Copper(II), the geometry shape of the complexes is octahedral.

Bacterial Diversity In Different Positions In The Iraqi Marine Area, Raghad Shubbar Jaafar, Asaad Al-Taee, Fadhil Neamah Al-Kanany

Baghdad Science Journal

Microorganisms establish both structural and functional construction in the marine environment, despite scientific advances, the identification of marine bacterial species is still considered as a common challenge in microbiology. Nevertheless, the present study aims to make an effort, although it seems modest, but it could establish a basis for studying the bacterial diversity in the Iraqi marine area, because of what this aspect entails of the poverty of studies related to this aspect in the studied area. The current results show the marine studied area are classified within worming area, where the average temperature ranged from 23.17 to 26.17 ºC. …

Synthesis, Characterization, And Thermal Analysis Of A New Acidicazo Ligand's Metal Complexes, Rasha Khider Hussain Al-Daffay, Abbas Ali Salih Al-Hamdani

Baghdad Science Journal

The researchers wanted to make a new azo imidazole as a follow-up to their previous work. The ligand 4-[(2-Amino-4-phenylazo)-methyl]-cyclohexane carboxylic acid as a derivative of trans-4-(aminomethyl) cyclohexane carboxylic acid diazonium salt, and synthesis a series of its chelate complexes with metalions, characterized these compounds using a variety technique, including elemental analysis, FTIR, LC-Mass, 1H-NMRand UV-Vis spectral process as well TGA, conductivity and magnetic quantifications. Analytical data showed that the Co (II) complex out to 1:1 metal-ligand ratio with square planner and tetrahedral geometry, respectively while 1:2 metal-ligand ratio in the Cu(II), Cr(III), Mn(II), Zn(II), Ru(III)and Rh(III)complexes with octahedral geometry except …

Study The Nuclear Structure Of Some Even-Even Ca Isotopes Using The Microscopic Theory, Ban Sabah Hameed, Tabarak Abdulla Alwan

Baghdad Science Journal

The root-mean square-radius of proton, neutron, matter and charge radii, energy level, inelastic longitudinal form factors, reduced transition probability from the ground state to first-excited 2+ state of even-even isotopes, quadrupole moments, quadrupole deformation parameter, and the occupation numbers for some calcium isotopes for A=42,44,46,48,50 are computed using fp-model space and FPBM interaction. 40Ca nucleus is regarded as the inert core for all isotopes under this model space with valence nucleons are moving throughout the fp-shell model space involving 1f7/2, 2p3/2, 1f5/2, and 2p1/2 orbits. Model space is used to present calculations using FPBM interaction, and with the effects of …

Financial Data Governance, Douglas W. Arner, Giuliano G. Castellano, Eriks K. Selga

UC Law Journal

Finance is one of the most digitalized, globalized, and regulated sectors of the global economy. Traditionally technology intensive, the financial industry has been at the forefront of digital transformation, starting with the dematerialization of financial assets in the 1960s and culminating in the post–2008 global financial crisis era with the fintech movement. Now, finance is data: financial transactions are transfers of data; financial infrastructures, such as stock exchanges and payment systems, are data networks; financial institutions are data processors, gathering, analyzing, and trading the data generated by their customers. Financial regulation has adapted to this fast-paced evolution both by implementing …

Deepfakes On Trial: A Call To Expand The Trial Judge’S Gatekeeping Role To Protect Legal Proceedings From Technological Fakery, Rebecca A. Delfino

UC Law Journal

Deepfakes—audiovisual recordings created using artificial intelligence (AI) technology to believably map one person’s movements and words onto another—are ubiquitous. They have permeated societal and civic spaces from entertainment, news, and social media to politics. And now deepfakes are invading the courts, threatening our justice system’s truth-seeking function. Ways deepfakes could infect a court proceeding run the gamut and include parties fabricating evidence to win a civil action, government actors wrongfully securing criminal convictions, and lawyers purposely exploiting a lay jury’s suspicions about evidence. As deepfake technology improves and it becomes harder to tell what is real, juries may start questioning …

Financial Inclusion Gone Wrong: Securities And Cryptoassets Trading For Children, Nizan Geslevich Packin

UC Law Journal

According to studies, money is a major source of anxiety for most Americans. In looking for ways to remedy the source of such anxiety, some believe that increasing children’s financial orientation could help lower their money-related anxiety levels as adults. Identifying this market as a business opportunity—and reassured by research that shows that by age six, children are already veteran consumers of mobile apps—financial technology (fintech), decentralized finance (DeFi), and even traditional financial entities have started offering services and products to children. These services and products include a broad array of financial-related products and services, from enabling children to earn …

Considering Vaccination Status, Govind Persad

UC Law Journal

This Article examines whether policies—sometimes termed “vaccine mandates” or “vaccine requirements”— that consider vaccination status as a condition of employment, receipt of goods and services, or educational or other activity for participation are legally permitted, and whether such policies may even sometimes be legally required. It does so with particular reference to COVID-19 vaccines.

Part I explains the legality of private actors, such as employers or private universities, considering vaccination status, and concludes that such consideration is almost always legally permissible unless foreclosed by specific state legislation. Part II examines the consideration of vaccination status by state or federal policy. …

Mistreatment And Exploitation Of Skilled Foreign Workers Through H- Visa Precarity, Isha Vazirani

UC Law Journal

The Department of Homeland Security (DHS) announced that beginning on May 26, 2015, certain H-4 dependents of H-1B nonimmigrants would be eligible to apply for an Employment Authorization Document (EAD). The H-4 EAD program was the target of several threats and changes under the Trump Administration, which made it increasingly difficult for H-4 EAD holders to maintain uninterrupted employment authorization. These difficulties prompted several lawsuits against the U.S. Citizenship and Immigration Services (USCIS), under DHS. USCIS favorably settled one such class-action lawsuit. Still, the H-4 EAD program remains only precariously in place because it was never officially codified and exists …

Loyalties V. Royalties, Sarah Polcz

UC Law Journal

Friendship rewards us with a bond of loyalty and equality. The marketplace rewards us based on what we have to offer. When friends work together to create something, and when the market judges their creation to have value, this sets up a clash between realms. Should the pie of profits be sliced according to the values of friendship or the values of the marketplace? The answer matters for policymakers concerned with creative incentives. How satisfied people are with their monetary rewards can turn more on how much others are getting—their relative rewards—than on the absolute amount received. Nevertheless, it is …

The Surprisingly Strong Case For Local Income Taxes In The Era Of Increased Remote Work, Erin Adele Scharff, Darien Shanske

UC Law Journal

Traditional theoretical literature on fiscal federalism urges cities to finance themselves with taxes on immobile sources. Thus, the literature sees real property taxes as the best source of local revenue; real property, after all, cannot be easily moved. This same literature eschews local income taxes because it is easy for a taxpayer to move, thus allowing exit from local income tax obligations.

Practice here seems to follow theory: cities do not tend to levy income taxes. However, this general trend has caused scholars to overlook important exceptions. In fact, many cities impose income taxes and have for a long time. …

Mitigating Catastrophe Risk For Landowners, Stewart E. Sterk

UC Law Journal

Local, national, and global catastrophes entail significant risk for landowners. The governmentsponsored National Flood Insurance Program illustrates how subsidizing insurance against catastrophe risk can result in overinvestment in risk-prone properties. Government intervention, however, has largely been a response to the historical failure of the private insurance industry to provide adequate protection against correlated risks, a failure with the potential to generate underinvestment in land and devastate existing owners.

When data is available about the incidence and severity of potential disasters, improvements in technology have made it more feasible for insurers to calibrate premiums and discounts with greater accuracy, and sophisticated …

Pole Cameras: Applying Fourth Amendment Protections To Emerging Surveillance Technology, Rahil Maharaj

UC Law Journal

Evolving surveillance technologies present unique challenges for the judiciary to maintain robust Fourth Amendment privacy protections. New surveillance tools such as pole cameras raise significant questions regarding the current scope of the Fourth Amendment and the steps the Supreme Court must take to prevent the erosion of a foundational constitutional right.

This Note lays out the current debate among scholars and courts regarding the impact of the Supreme Court’s decision in Carpenter v. United States. It demonstrates the challenge that new technology presents by providing an overview of the split between state and federal circuit courts in applying Carpenter to …

Foreign Investment And National Security Challenges In The Data Age: An Assessment Of The Current Regime And Recommendations, Irene Yu

UC Law Journal

This Note contributes to the growing literature that attempts to grasp the current landscape of international trade and investment norms and policies in the data age. Focusing on the disputes between the United States and China surrounding Chinese investment in American businesses that gather private user data, this Note adds to the argument that new challenges posed by the internet age and the use of private data have transformed current international trade policy and the national security exception regime. The U.S. government in the recent years has demonstrated little self-restraint in employing national security grounds to justify its interference with …

Experiences Embodied & Remembered: Contemporary Artists Engaging Contemporary Concerns, Michelle Ried

Bridwell Library Publications

No abstract provided.

Defining A Cyber Operations Performance Framework Via Computational Modeling, Briant Becote

Masters Theses & Doctoral Dissertations

Cyber operations are influenced by a wide range of environmental characteristics, strategic policies, organizational procedures, complex networks, and the individuals who attack and defend these cyber battlegrounds. While no two cyber operations are identical, leveraging the power of computational modeling will enable decision-makers to understand and evaluate the effect of these influences prior to their impact on mission success. Given the complexity of these influences, this research proposes an agent-based modeling framework that will result in an operational performance dashboard for user analysis. To account for cyber team behavioral characteristics, this research includes the development and validation of the Cyber …

Enhanced Convolutional Neural Network For Non-Small Cell Lung Cancer Classification, Yahya Tashtoush, Rasha Obeidat, Abdallah Al-Shorman, Omar Darwish, Mohammad A. Al-Ramahi, Dirar Darweesh

Computer Information Systems Faculty Publications (Archived)

Lung cancer is a common type of cancer that causes death if not detected
early enough. Doctors use computed tomography (CT) images to diagnose
lung cancer. The accuracy of the diagnosis relies highly on the doctor's
expertise. Recently, clinical decision support systems based on deep learning
valuable recommendations to doctors in their diagnoses. In this paper, we
present several deep learning models to detect non-small cell lung cancer in
CT images and differentiate its main subtypes namely adenocarcinoma,
large cell carcinoma, and squamous cell carcinoma. We adopted standard
convolutional neural networks (CNN), visual geometry group-16 (VGG16),
and VGG19. Besides, we …

Analysis Of Freight Movements In The San Joaquin Valley, Aly Tawfik, Utsav Shah

Mineta Transportation Institute

Freight transportation plays a primary role in supply chains, costs, and availability of goods and is a major part of the economy. This study identifies, assesses, and utilizes different data sources to uncover and understand the patterns and movements of different types of freight in the San Joaquin Valley’s (SJV's) different counties. The San Joaquin Valley region consists of eight counties: San Joaquin, Stanislaus, Merced, Madera, Fresno, Kings, and Tulare. This research explored some major datasets with freight information, such as Global Trade Atlas (GTA), Port Imports and Exports Reporting Systems (PIERS), and Streetlight data insights for the year 2019 …

Trade And Transportation Talent Pipeline Blueprints: Building Universityindustry Talent Pipelines In Colleges Of Continuing And Professional Education, Tyler D. Reeb, Stacey Park

Mineta Transportation Institute

The rapid adoption of transformational technologies along with other economic and cultural shifts, have created a gap between workers and the skills and knowledge necessary for in-demand occupations. Trade and Transportation Talent Pipeline Blueprints: Building University-Industry Talent Pipelines in Colleges of Continuing and Professional Education identifies the steps required to build talent pipelines that target in-demand trade and transportation occupations requiring specific degrees, certificates, and non-credit professional development. This report provides a literature review and labor market data analysis. It also includes documentation of methodology in planning a pilot program for Colleges of Professional and Continuing Education housed within each …

Constructing An Extensive Hail Damage Swath Database For Impact Analysis And Future Applications, Emily Faith Wisinski

Honors Capstone Projects and Theses

No abstract provided.

Diamond's Hidden Gems - Sage Research Methods, Diamond Williams

Libraries' Documents

Nearly everyone at UCF is involved in research, from students learning how to conduct research for the first time to faculty conducting research for publication. There are many programs and resources that motivate students to participate, from the Student Scholar Symposium to the Undergraduate Research Fellowship.

SAGE Research Methods supports research at all levels by providing material to guide users through every step of the research process. Read on to learn more about what this resources can do for you, and how to access it!

Quantum Copyright Law: Schrodinger's Cat, Banksy's Shredder, And Art On The Edge, Richard H. Chused

Articles & Chapters

An object has been assembled by artists I know that presents a fascinating set of conundrums about the relationships between quantum physics, shredders, random surprises, the value of art, and copyright law. Seems fantastical, right? And so it is. The object of concern is a metal box a little under four feet tall, about eighteen inches deep, and a bit less than three feet wide. The box is welded together along all twelve of its edges. It has an opening across one side. And there is a small control panel on top. Before the box was welded shut, a set …

Trauma Presentation Among Latinx/Hispanic Subgroups, Ana Paula Leao De Camargo

Theses and Dissertations

Hispanics/Latinos are the fastest-growing minority group in the United States and are estimated to compose half of the American population by 2060 if growing trends follow current levels. It has been suggested that Latinx/Hispanics perceive and react to adverse experiences with somatization, which is highly comorbid with Post-traumatic Stress Disorder (PTSD) symptoms (van der Kolk, et al 1996). This study surveyed 451 participants from which 88% identified as being Hispanic or Latinas, 2.7% identified as being Black Hispanic/Black Latina, and 9.3% identified as having mixed ethnicities including Hispanic/Latina. Regarding place of birth, 431 respondents (95.6%) identified being born in Continental …

United States National Science Foundation Response To The Office Of Science And Technology Policy Memo, 2022: Public Access Plan (February 2023)

Copyright, Fair Use, Scholarly Communication, etc.

NSF response to OSTP memo, 2022: Public Access Plan (February 2023)