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Effortful Control Moderates The Relation Between Negative Emotionality And Child Anxiety And Depressive Symptom Severity In Children With Anxiety Disorders, Elizabeth M Raines, Andres G Viana, Erika S Trent, Haley E Conroy, Karina Silva, Michael J Zvolensky, Eric A Storch Feb 2023

Effortful Control Moderates The Relation Between Negative Emotionality And Child Anxiety And Depressive Symptom Severity In Children With Anxiety Disorders, Elizabeth M Raines, Andres G Viana, Erika S Trent, Haley E Conroy, Karina Silva, Michael J Zvolensky, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

The present study investigated the interactive effect of reactive (negative emotionality) and regulatory (effortful control) aspects of temperament in the prediction of child anxiety and depressive symptoms. Clinically anxious children and their mothers completed a battery of questionnaires that included self- and mother-ratings of child effortful control, negative emotionality, anxiety, and depressive symptoms. Multiple regression analyses were conducted to examine the moderating effect of effortful control on the relation between negative emotionality and child anxiety and depressive symptom severity. The interaction between negative emotionality and effortful control was statistically significant and simple slopes revealed that as effortful control increased, the …


Selection Of Solidification Pathway In Rapid Solidification Processes, Nima Najafizadeh, Men G. Chu, Yijia Gu Feb 2023

Selection Of Solidification Pathway In Rapid Solidification Processes, Nima Najafizadeh, Men G. Chu, Yijia Gu

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Rapid Solidification Processing of Alloys Enables the Formation of Exotic Nonequilibrium Microstructures. However, the Interrelationship between the Processing Parameters and the Resulting Microstructure is Yet to Be Fully Understood. in Melt Spinning (MS) and Additive Manufacturing (AM) of Rapidly Solidified Alloys, Opposite Microstructure Development Sequences Were Observed. a Fine-To-Coarse Microstructural Transition is Typically Observed in Melt-Spun Ribbons, Whereas Melt Pools in AM Exhibit a Coarse-To-Fine Transition. in This Paper, the Microstructural Evolutions during These Two Processes Are Investigated using Phase-Field Modeling. the Variation of All Key Variables of the Solid-Liquid Interface (Temperature, Composition, and Velocity) throughout the Entire Rapid Solidification …


Borderplex Business Barometer, Volume 7, Number 2, Thomas M. Fullerton Jr., Steven L. Fullerton Feb 2023

Borderplex Business Barometer, Volume 7, Number 2, Thomas M. Fullerton Jr., Steven L. Fullerton

Border Region Modeling Project

No abstract provided.


Beyond Varices: Complications Of Cirrhotic Portal Hypertension In Pediatrics, Anna M Banc-Husu, Henry Shiau, Peace Dike, Benjamin L Shneider Feb 2023

Beyond Varices: Complications Of Cirrhotic Portal Hypertension In Pediatrics, Anna M Banc-Husu, Henry Shiau, Peace Dike, Benjamin L Shneider

Faculty, Staff and Students Publications

Complications of cirrhotic portal hypertension (PHTN) in children are broad and include clinical manifestations ranging from variceal hemorrhage, hepatic encephalopathy (HE), ascites, spontaneous bacterial peritonitis (SBP), and hepatorenal syndrome (HRS) to less common conditions such as hepatopulmonary syndrome, portopulmonary hypertension, and cirrhotic cardiomyopathy. The approaches to the diagnosis and management of these complications have become standard of practice in adults with cirrhosis with many guidance statements available. However, there is limited literature on the diagnosis and management of these complications of PHTN in children with much of the current guidance available focused on variceal hemorrhage. The aim of this review …


Superior Verbal Learning And Memory In Pediatric Brain Tumor Survivors Treated With Proton Versus Photon Radiotherapy, Lisa E Mash, Lisa S Kahalley, M Fatih Okcu, David R Grosshans, Arnold C Paulino, Heather Stancel, Luz De Leon, Elisabeth Wilde, Nilesh Desai, Zili D Chu, William E Whitehead, Murali Chintagumpala, Kimberly P Raghubar Feb 2023

Superior Verbal Learning And Memory In Pediatric Brain Tumor Survivors Treated With Proton Versus Photon Radiotherapy, Lisa E Mash, Lisa S Kahalley, M Fatih Okcu, David R Grosshans, Arnold C Paulino, Heather Stancel, Luz De Leon, Elisabeth Wilde, Nilesh Desai, Zili D Chu, William E Whitehead, Murali Chintagumpala, Kimberly P Raghubar

Faculty, Staff and Student Publications

OBJECTIVE: Radiotherapy for pediatric brain tumor has been associated with late cognitive effects. Compared to conventional photon radiotherapy (XRT), proton radiotherapy (PRT) delivers lower doses of radiation to healthy brain tissue. PRT has been associated with improved long-term cognitive outcomes compared to XRT. However, there is limited research comparing the effects of XRT and PRT on verbal memory.

METHOD: Survivors of pediatric brain tumor treated with either XRT (

RESULTS: Overall, patients receiving PRT demonstrated superior verbal learning and recall compared to those treated with XRT. Encoding and retrieval deficits were more common in the XRT group than the PRT …


A Novel Data-Driven Method For Two-Dimensional Angles Finding Via Uniform Rectangular Array With Automatic Pairing, Yanming Zhang, Lijun Jiang Feb 2023

A Novel Data-Driven Method For Two-Dimensional Angles Finding Via Uniform Rectangular Array With Automatic Pairing, Yanming Zhang, Lijun Jiang

Electrical and Computer Engineering Faculty Research & Creative Works

A new hybrid dynamic mode decomposition (HDMD) algorithm is proposed to estimate the azimuth and elevation angles of multiple independent sources for two-dimensional (2D) massive MIMO systems with the uniform rectangular array (URA). To this end, the proposed hybrid scheme integrates the modified DMD with the augmented DMD. By treating the received data as spatial-spatial correlated signals, the modified DMD is first used to decompose these signals into spatial DMD spectrum and corresponding spatial dynamic modes. The obtained spatial DMD spectrum directly yields the electrical angle in the y-direction. Then, the corresponding electrical angle in the x-direction is computed using …


The Disembodied First Amendment, Nathan Cortez, William M. Sage Feb 2023

The Disembodied First Amendment, Nathan Cortez, William M. Sage

Faculty Scholarship

First Amendment doctrine is becoming disembodied—increasingly detached from human speakers and listeners. Corporations claim that their speech rights limit government regulation of everything from product labeling to marketing to ordinary business licensing. Courts extend protections to commercial speech that ordinarily extended only to core political and religious speech. And now, we are told, automated information generated for cryptocurrencies, robocalling, and social media bots are also protected speech under the Constitution. Where does it end? It begins, no doubt, with corporate and commercial speech. We show, however, that heightened protection for corporate and commercial speech is built on several “artifices” - …


February 2023 Louisiana Bar Exam, Louisiana Supreme Court Committee On Bar Admissions Feb 2023

February 2023 Louisiana Bar Exam, Louisiana Supreme Court Committee On Bar Admissions

Louisiana Bar Exams

No abstract provided.


Remote Internal Wave Forcing Of Regional Ocean Simulations Near The U.S. West Coast, Oladeji Q. Siyanbola, Maarten C. Buijsman, Audrey Delpech, Lionel Renault, Roy Barkan, Jay F. Shriver, Brian K. Arbic, James C. Mcwilliams Feb 2023

Remote Internal Wave Forcing Of Regional Ocean Simulations Near The U.S. West Coast, Oladeji Q. Siyanbola, Maarten C. Buijsman, Audrey Delpech, Lionel Renault, Roy Barkan, Jay F. Shriver, Brian K. Arbic, James C. Mcwilliams

Faculty Publications

Low mode internal waves are able to propagate across ocean basins and modulate ocean dynamics thousands of kilometers away from their generation sites. In this study, the impact of remotely generated internal waves on the internal wave energetics near the U.S. West Coast is investigated with realistically forced regional ocean simulations. At the open boundaries, we impose high-frequency oceanic state variables obtained from a global ocean simulation with realistic atmospheric and astronomical tidal forcing. We use the Discrete Fourier Transform (DFT) technique in separating ingoing and outgoing internal tide energy fluxes at the open boundaries in order to quantify internal …


Floating Liquid Droplets On The Surface Of Cryogenic Liquids: Implications For Titan Rain, Kendra Farnsworth, Alejandro Soto, Vincent F. Chevrier, Jordan K. Steckloff, Jason M. Soderblom Feb 2023

Floating Liquid Droplets On The Surface Of Cryogenic Liquids: Implications For Titan Rain, Kendra Farnsworth, Alejandro Soto, Vincent F. Chevrier, Jordan K. Steckloff, Jason M. Soderblom

Space and Planetary Science Faculty Publications and Presentations

Saturn’s moon, Titan, has a hydrocarbon-based hydrologic cycle with methane and ethane rainfall. Because of Titan’s low gravity, “floating liquid droplets” (coherent droplets of liquid hydrocarbons that float upon a liquid surface) may form on the surface of Titan’s hydrocarbon lakes and seas during rainfall. Floating liquid droplets, however, have not been investigated in the laboratory under conditions appropriate for the surface of Titan (cryogenic, hydrocarbon, liquids). We conducted a set of experiments to simulate methane and ethane rainfall under Titan surface conditions (89–94 K, 1.5 bar nitrogen atmosphere) and find that floating ethane droplets form in a wide range …


Designing Interfaith Leadership And Ethics Course, Michael Hubbard Mackay Feb 2023

Designing Interfaith Leadership And Ethics Course, Michael Hubbard Mackay

Instructional Psychology and Technology Graduate Student Projects

This course will enable Religious Education to embrace the mission of the Church of Jesus Christ of Latter-day Saints and Brigham Young University more fully. This course serves as a foundational introduction for students to discover the nature of interfaith work. Students who fully embrace Brigham Young University’s expansive motto “Enter to Learn, Go Forth to Serve” are vocationally responsible to bring good into reach for themselves, their families, their communities, their Church, and above all and undergirding all, the world. In this endeavor, students must and will engage with individuals who hold deep convictions of religious faith and affiliation, …


Racial Differences In Time To Blood Pressure Control Of Aneurysmal Subarachnoid Hemorrhage Patients: A Single-Institution Study, Xiaofei Zhou, Adam Hwan Bates, Uma V. Mahajan, Ansh Desai, Jeffrey Butke, Yifei Duan, Christopher Burant, Kaylee Sarna, Martha Sajatovic, Dhimant Dani, S. Alan Hoffer Feb 2023

Racial Differences In Time To Blood Pressure Control Of Aneurysmal Subarachnoid Hemorrhage Patients: A Single-Institution Study, Xiaofei Zhou, Adam Hwan Bates, Uma V. Mahajan, Ansh Desai, Jeffrey Butke, Yifei Duan, Christopher Burant, Kaylee Sarna, Martha Sajatovic, Dhimant Dani, S. Alan Hoffer

Faculty Scholarship

Background and purpose Aneurysmal subarachnoid hemorrhage occurs in approximately 30,000 patients annually in the United States. Uncontrolled blood pressure is a major risk factor for aneurysmal subarachnoid hemorrhage. Clinical guidelines recommend maintaining blood pressure control until definitive aneurysm securement occurs. It is unknown whether racial differences exist regarding blood pressure control and outcomes (HLOS, discharge disposition) in aneurysmal subarachnoid hemorrhage. Here, we aim to assess whether racial differences exist in 1) presentation, 2) clinical course, and 3) outcomes, including time to blood pressure stabilization, for aSAH patients at a large tertiary care medical center. Methods We conducted a retrospective review …


“It Can Be Chaos Here” International Student Experiences Of U.S. Higher Education During The Covid-19 Pandemic, Peter G. Ghazarian, Babita Bhandari, Shuoyu Chen Feb 2023

“It Can Be Chaos Here” International Student Experiences Of U.S. Higher Education During The Covid-19 Pandemic, Peter G. Ghazarian, Babita Bhandari, Shuoyu Chen

Journal of Comparative & International Higher Education

No abstract provided.


Columns Spring 2023, Southern Adventist University Feb 2023

Columns Spring 2023, Southern Adventist University

Alumni Newsletter

Features information about early childhood education, small business endeavors, service opportunities, and the dedication of land for the future School of Business facility.


Neutron Imaging Of Al6061 Prepared By Solid-State Friction Stir Additive Manufacturing, Saber Nemati, Leslie G. Butler, Kyungmin Ham, Gerald L. Knapp, Congyuan Zeng, Selami Emanet, Hamed Ghadimi, Shengmin Guo, Yuxuan Zhang, Hassina Bilheux Feb 2023

Neutron Imaging Of Al6061 Prepared By Solid-State Friction Stir Additive Manufacturing, Saber Nemati, Leslie G. Butler, Kyungmin Ham, Gerald L. Knapp, Congyuan Zeng, Selami Emanet, Hamed Ghadimi, Shengmin Guo, Yuxuan Zhang, Hassina Bilheux

Faculty Publications

Solid-state Friction Stir Additive Manufacturing has recently gained attention as a result of its capacity to fabricate large-scale parts while preserving the mechanical properties of the feedstock material. However, the correlation between the quality of layer-by-layer bonding of the deposited metal and processing parameters has remained unknown. Neutron imaging techniques, with 90% total transmission per cm, are employed for Al6061 parts fabricated by MELD® Technology as a non-destructive evaluation approach for the first time to investigate the layer-by-layer structure of a stadium-shaped ingot in different sections. The post-processed results show the fabricated parts with an optimized set of processing parameters …


Hardness Distribution Of Al2050 Parts Fabricated Using Additive Friction Stir Deposition, Hamed Ghadimi, Huan Ding, Selami Emanet, Mojtaba Talachian, Chase Cox, Michael Eller, Shengmin Guo Feb 2023

Hardness Distribution Of Al2050 Parts Fabricated Using Additive Friction Stir Deposition, Hamed Ghadimi, Huan Ding, Selami Emanet, Mojtaba Talachian, Chase Cox, Michael Eller, Shengmin Guo

Faculty Publications

The solid-state additive friction stir deposition (AFSD) process is a layer-by-layer metal 3D-printing technology. In this study, AFSD is used to fabricate Al–Cu–Li 2050 alloy parts. The hardness values for various regions of the as-deposited built parts are measured, and the results are contrasted with those of the feedstock material. The as-fabricated Al2050 parts are found to have a unique hardness distribution due to the location-specific variations in the processing temperature profile. The XRD results indicate the presence of the secondary phases in the deposited parts, and EDS mapping confirms the formation of detectable alloying particles in the as-deposited Al2050 …


Wind Loads On Overhead Sign Structures: A Comparative Study, Aly Mousaad Aly, James Benson Feb 2023

Wind Loads On Overhead Sign Structures: A Comparative Study, Aly Mousaad Aly, James Benson

Faculty Publications

Road signs are prone to extreme winds that cause significant damage. Overhead sign structures can disrupt traffic and cause harm to the traveling public if a failure occurs under extreme wind conditions. In this paper, we employ Computational Fluid Dynamics (CFD) in a comparative study to understand the aerodynamics of standard, porous, and curved signs. The study shows the viability of porous and curved overhead boards for lessening aerodynamic loads, which can mini-mize damage and enhance safety on roadways. Porous overhead signs can decrease the drag forces; however, the size of the openings is a vital parameter in reducing wind …


Vibration Attenuation In A High-Rise Hybrid-Timber Building: A Comparative Study, Suvash Chapain, Aly Mousaad Aly Feb 2023

Vibration Attenuation In A High-Rise Hybrid-Timber Building: A Comparative Study, Suvash Chapain, Aly Mousaad Aly

Faculty Publications

Recent developments in engineered timber products, and their availability, durability, and renewability, have led to taller and more flexible buildings. However, these buildings may experience excessive vibrations, resulting in safety and serviceability issues due to wind or earthquake loads. This paper presents a dynamic analysis of a 42-story-tall hybrid-timber building, along with a comparative study of the performance of three damping devices: (i) pendulum pounding tuned mass damper (PTMD), (ii) tuned mass damper inerter (TMDI), and (iii) tuned mass damper (TMD). First, we evaluate the vibration reduction capability of the TMD and the TMDI under filtered white noise and variable …


Becoming A Spiritually Formed Leader An Invitation To A Life-Long Journey Of Stability, Fidelity, And Obedience, Brad Pembleton Feb 2023

Becoming A Spiritually Formed Leader An Invitation To A Life-Long Journey Of Stability, Fidelity, And Obedience, Brad Pembleton

Doctor of Ministry

The project was developed in response to the following need within non-denominational churches that lack vision and resources to invest in their spiritual leaders: Leaders of non-denominational churches should be trained and equipped to attend to a life-long process of being spiritually formed to effectively nurture God’s people. To address an overwhelming need for spiritual leaders to grow in their spiritual formation to the glory of God and for the sake of others, this is a two-fold strategy that utilizes both the left and right brain to engage beliefs, doctrine and strategies while also focusing on relational experiences, emotional development …


Gcm: Generations In Community On Mission A Theoretical Framework For Intergenerational Disciples On Mission, Denise C. Johnson Feb 2023

Gcm: Generations In Community On Mission A Theoretical Framework For Intergenerational Disciples On Mission, Denise C. Johnson

Doctor of Ministry

The increasingly unstable and changing world in which we now live requires a resilient, discerning, and adaptable family of God, who is intentional about reaching their community with the hope of Jesus. This project sought to address the disconnect between the congregants, the relational network, and the tools necessary to walkout the fulfillment of their identity on mission. The following NPO was initiated due to my background working in disenfranchised settings within public schools as a Special Educator and School Counselor and the three decades working in interdenominational foreign missions’ partnership, together with Foursquare Missions International. This final form was …


Infobesity: How Does Information Overload From Digital Technologies Affect Our Relationship With Jesus, Andy Gabruch Feb 2023

Infobesity: How Does Information Overload From Digital Technologies Affect Our Relationship With Jesus, Andy Gabruch

Doctor of Ministry

My research project is based on the NPO of how information overload from digital technologies affects our relationship with Jesus, according to Mark 12:30-31, and how followers of Jesus can redeem digital spaces. My key insights of the research led me to the conclusion digital information overload is based on the lack of moderation and regulation of digital technologies as followers of Jesus. Furthermore, my research led me to the effects of information overload to five categories Jesus speaks of in Mark 12:30-31 of our hearts (emotions), soul (identity), mind (cognitive reasoning), strength (physical), and relationships (social skills) according to …


Storied Discipleship: Nine Practices For Jesus-Shaped Living, David Bach Feb 2023

Storied Discipleship: Nine Practices For Jesus-Shaped Living, David Bach

Doctor of Ministry

This project germinated out of the observation that many evangelical congregations are facing the malaise of a profound lack of true faith formation, which is creating a wide gap between authentic Christ formation and secularization, and is further exacerbated by the genuine blind spot of denial in the minds of Christians that this is problematic. In a distracted and frenzied world, faith formation is becoming less of a priority, which is caused by an inherent bent toward selfish independence. Changing the narrative on these observations would mean Christians prioritize and cultivate their relationship with Jesus Christ, propelling them outwardly towards …


Mckee Minute February 2023, Southern Adventist University Feb 2023

Mckee Minute February 2023, Southern Adventist University

McKee Minute – McKee Library This Month

The February 2023 issue of McKee Minute includes information on Campus Research Day, Black History Month, interlibrary loan, and new books.


The Mechanism And Therapy Of Aortic Aneurysms, Jianing Gao, Huanhuan Cao, Gaofei Hu, Yufei Wu, Yangkai Xu, Hongtu Cui, Hong S. Lu, Lemin Zheng Feb 2023

The Mechanism And Therapy Of Aortic Aneurysms, Jianing Gao, Huanhuan Cao, Gaofei Hu, Yufei Wu, Yangkai Xu, Hongtu Cui, Hong S. Lu, Lemin Zheng

Saha Cardiovascular Research Center Faculty Publications

Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally asymptomatic, it poses a significant threat to human life due to a high risk of rupture. Because of its strong concealment, it is difficult to diagnose the disease in the early stage. At present, there are no effective drugs for the treatment of aneurysms. Surgical intervention and endovascular treatment are the only therapies. Although current studies have discovered that inflammatory responses as well as the production and activation of various proteases promote aortic aneurysm, the specific mechanisms remain unclear. Researchers are further exploring the pathogenesis …


A Simple Micromilled Microfluidic Impedance Cytometer With Vertical Parallel Electrodes For Cell Viability Analysis, Jason Eades, Julianne F. Audiffred, Micah Fincher, Jin Woo Choi, Steven A. Soper, William Todd Monroe Feb 2023

A Simple Micromilled Microfluidic Impedance Cytometer With Vertical Parallel Electrodes For Cell Viability Analysis, Jason Eades, Julianne F. Audiffred, Micah Fincher, Jin Woo Choi, Steven A. Soper, William Todd Monroe

Faculty Publications

Microfluidic impedance cytometry has been demonstrated as an effective platform for single cell analysis, taking advantage of microfabricated features and dielectric cell sensing methods. In this study, we present a simple microfluidic device to improve the sensitivity, accuracy, and throughput of single suspension cell viability analysis using vertical sidewall electrodes fabricated by a widely accessible negative manufacturing method. A microchannel milled through a 75 µm platinum wire, which was embedded into poly-methyl-methacrylate (PMMA), created a pair of parallel vertical sidewall platinum electrodes. Jurkat cells were interrogated in a custom low-conductivity buffer (1.2 ± 0.04 mS/cm) to reduce current leakage and …


Challenges Faced By Journalists In Digital Media Enterprises And How To Overcome Them, Robert Ndungu Feb 2023

Challenges Faced By Journalists In Digital Media Enterprises And How To Overcome Them, Robert Ndungu

Master of Arts in Digital Journalism

This study aims to identify the challenges faced in successfully transitioning to becoming a digital journalist and the solutions to these problems in a way that creates a template or blueprint to replicate for other journalists. In chapter 1, there is the introduction and background which highlight these challenges including difficulties in having regular training about new tools and technologies. It highlights the struggle digital journalists face to understand their roles and responsibilities, especially in the context of the DME's own interpretation, the advocacy for good mental health and stress management support in the workplace and the complexities of flexible …


Human Resource Management In The Digital Era: Leading A Multi-Generational Workforce In Kenyan Newsrooms, Caroline Wambui Mwangi Feb 2023

Human Resource Management In The Digital Era: Leading A Multi-Generational Workforce In Kenyan Newsrooms, Caroline Wambui Mwangi

Master of Arts in Digital Journalism

Human resources are a key pillar for driving media leadership and innovation. These resources are, however, very diverse in terms of skills, expertise, gender, areas of specialization and age among other factors. This study set out to critically examine and understand the dynamics of multi-generational digital newsrooms in Kenya and provide recommendations and strategies for how they can be managed better to ensure productivity and sustainability. Chapter one of this document provided an introduction and background to the study. This chapter also outlined the rationale of the study, the literature review, the problem statement, research objectives and questions, the research …


Convergence Newsroom Culture In Legacy News Media: An Ethnographic Study Of The Standard Group Plc, Caroline Jerotich Kimutai Feb 2023

Convergence Newsroom Culture In Legacy News Media: An Ethnographic Study Of The Standard Group Plc, Caroline Jerotich Kimutai

Master of Arts in Digital Journalism

In the last decade, the media industry has been under immense financial pressure because of declining advertising revenue. News media organisations especially traditional media are moving away from a business model that only relies on traditional commercial advertising, to one that offers multiple streams of revenue like digital subscriptions, native advertising, classifieds, events, sponsorships, affiliate marketing among others. In 2020, the Standard Group converged its newsroom operations into a digital-first news gathering and dissemination operation (Theuri, 2021). There had been previous attempts at convergence, only this time, a changing media environment was threatening the survival of the media house. Over …


Ipulse: February 2023, Lynn University Feb 2023

Ipulse: February 2023, Lynn University

Student Newspapers

Issues:

  • February 2023 [Spring Week #3]: How to be Alone on Valentine's Day; Alix Earle: TikTok's Newest 'It Girl'; The Fashion Icons Students Love; Coping Strategies to Deal with Homesickness; It Ends with You, Hoover; Deglamorizing the Lack of Self-Care in College Students; South Florida's Hidden Ice Cream Parlor
  • February 2023 [Spring Week #4]: The Value of Citizenship; How to: Break the Stigma; A Body in Motion Tends to Stay in Motion; #Oscarssomale; Travel to the Max; It's Me, Ticketmaster, Hi, I'm the Problem, It's Me; Fresh Food, Fresh Kitchen


Association Of The Lncrna-Gas5 Promoter Region Rs145204276 Polymorphism With Sevoflurane Maintenance Anesthesia Outcomes On Patients Undergoing Laparoscopic Cholecystectomy, Panpan Zhang, Zhanming Sha Feb 2023

Association Of The Lncrna-Gas5 Promoter Region Rs145204276 Polymorphism With Sevoflurane Maintenance Anesthesia Outcomes On Patients Undergoing Laparoscopic Cholecystectomy, Panpan Zhang, Zhanming Sha

Saudi Medical Journal

Objectives: To further investigate how sevoflurane affects the oxidative stress injury (OSI) in patients undergoing laparoscopic cholecystectomy (LC). Methods: A prospective cohort study was carried out at Shandong Provincial Third Hospital, Jinan, China on 82 gallstone patients who underwent LC, with sevoflurane maintenance during surgery. Genotyping analysis of the rs145204276 polymorphism was performed using the TaqMan platform. Oxidative stress injury and liver injury parameters were also examined. Lipopolysaccharide (LPS)-induced macrophages, which were challenged with sevoflurane, propofol, or the lncRNA-GAS5 overexpressing plasmid, were used to evaluate the effect of Sevoflurane on lncRNA-GAS5-mediated macrophage polarization. Results: At TM1 and TM2, the levels …