Digital Commons Network^™

Computational Fluid Dynamics Analysis And Empirical Evaluation Of Carboxymethylcellulose/Alginate 3d Bioprinting Inks For Screw-Based Microextrusion, Sungmin Lee, Minjae Son, Juo Lee, Iksong Bun, Jin-Woo Kim, Jungsil Kim, Hoon Seonwoo

Biological and Agricultural Engineering Faculty Publications and Presentations

Three-dimensional microextrusion bioprinting technology uses pneumatics, pistons, or screws to transfer and extrude bioinks containing biomaterials and cells to print biological tissues and organs. Computational fluid dynamics (CFD) analysis can simulate the flow characteristics of bioinks in a control volume, and the effect on cell viability can be predicted by calculating the physical quantities. In this study, we developed an analysis system to predict the effect of a screw-based dispenser system (SDS) on cell viability in bioinks through rheological and CFD analyses. Furthermore, carboxymethylcellulose/alginate-based bioinks were used for the empirical evaluation of high-viscous bioinks. The viscosity of bioinks was determined …

Validity Of Self-Reported Weight And Height Among Female Young Adults In The United Arab Emirates, Dalia Haroun, Aseel Ehsanallah

All Works

Self-reported weight and height serve as important metrics in estimating overweight and obesity prevalence within epidemiological studies, primarily due to their cost and time efficiency. However, the accuracy and reliability of these self-reported measures remain controversial, with conflicting reports emerging from different regions. This study aims to compare self-reported weight and height with measured values among young female adults in the United Arab Emirates. A cross-sectional study of 131 female university students aged 17-27 reported their weight and height on a self-administered questionnaire and on the same day had their height and weight measured. Body Mass Index (BMI) values of …

Conference Program, Georgia Southern University

GS4 Student Scholars Symposium

No abstract provided.

First-In-Human Phase I Trial Of Tpst-1120, An Inhibitor Of Pparα, As Monotherapy Or In Combination With Nivolumab, In Patients With Advanced Solid Tumors, Bruno Bastos

All Publications

Purpose: TPST-1120 is a first-in-class oral inhibitor of peroxisome proliferator-activated receptor α (PPARα), a fatty acid ligand-activated transcription factor that regulates genes involved in fatty acid oxidation, angiogenesis, and inflammation, and is a novel target for cancer therapy. TPST-1120 displayed antitumor activity in xenograft models and synergistic tumor reduction in syngeneic tumor models when combined with anti-PD-1 agents.

Experimental design: This phase I, open-label, dose-escalation study (NCT03829436) evaluated TPST-1120 as monotherapy in patients with advanced solid tumors and in combination with nivolumab in patients with renal cell carcinoma (RCC), cholangiocarcinoma (CCA), or hepatocellular carcinoma. Objectives included evaluation of …

Statistics For Iwasawa Invariants Of Elliptic Curves, Ii, Debanjana Kundu, Anwesh Ray

School of Mathematical & Statistical Sciences Faculty Publications

We study the average behavior of the Iwasawa invariants for Selmer groups of elliptic curves. These results lie at the intersection of arithmetic statistics and Iwasawa theory. We obtain lower bounds for the density of rational elliptic curves with prescribed Iwasawa invariants.

Dismantling Barriers To Hepatitis B And Delta Screening, Prevention, And Linkage To Care Among The Pwud Community In Philadelphia, Beatrice Zovich, Catherine Freeland, Holly Moore, Kara Sapp, Anousha Qureshi, Rachel Holbert, Jason Zambrano, Daljinder Bhangoo, Chari Cohen, Richard W. Hass, Amy Jessop

College of Population Health Faculty Papers

The prevalence of hepatitis B and delta viruses (HBV/HDV) among people who use drugs (PWUD) remains largely unknown. In the context of one Philadelphia-based harm reduction organization (HRO), this study aimed to assess HBV/HDV prevalence and facilitate linkage to care. Participants completed a demographic HBV/HDV risk factor survey and were screened for HBV and reflexively for HDV if positive for HBV surface antigen or isolated core antibody. Fisher's exact tests and regression were used to understand relationships between risks and HBV blood markers. Of the 498 participants, 126 (25.3%) did not have hepatitis B immunity, 52.6% had been vaccinated against …

Advancing Brain Tumor Segmentation With Spectral–Spatial Graph Neural Networks, Sina Mohammadi, Mohamed Allali

Engineering Faculty Articles and Research

In the field of brain tumor segmentation, accurately capturing the complexities of tumor sub-regions poses significant challenges. Traditional segmentation methods usually fail to accurately segment tumor subregions. This research introduces a novel solution employing Graph Neural Networks (GNNs), enriched with spectral and spatial insight. In the supervoxel creation phase, we explored methods like VCCS, SLIC, Watershed, Meanshift, and Felzenszwalb–Huttenlocher, evaluating their performance based on homogeneity, moment of inertia, and uniformity in shape and size. After creating supervoxels, we represented 3D MRI images as a graph structure. In this study, we combined Spatial and Spectral GNNs to capture both local and …

The Lowest Discriminant Ideal Of Cayley-Hamilton Hopf Algebras, Zhongkai Mi

LSU Doctoral Dissertations

Discriminant ideals are defined for an algebra R with central subalgebra C and trace tr : R → C. They are indexed by positive integers and more general than discriminants. Usually R is required to be a finite module over C. Unlike the abundace of work on discriminants, there is hardly any literature on discriminant ideals. The levels of discriminant ideals relate to the sums of squares of dimensions of irreducible modules over maximal ideals of C containing these discriminant ideals. We study the lowest level when R is a Cayley-Hamilton Hopf algebra, i.e. C is also a Hopf subalgebra, …

Laxative Use In Adults With Intellectual Disabilities: Development Of Prescribing Guidelines, Ruth Bishop, Richard Laugharne, Lisa Burrows, Sandra Ward, Sharon Eustice, David Branford, Mike Wilcock, Kirsten Lamb, Alison Tavare, Charlotte Annesley, Stephen Lewis, Vasileios Voulgaropoulos, Faye Sleeman, Beth Sargent, Rohit Shankar

Peninsula Medical School

Background Constipation is overrepresented in people with intellectual disabilities. Around 40% of people with intellectual disabilities who died prematurely were prescribed laxatives. A quarter of people with intellectual disabilities are said to be on laxatives. There are concerns that prescribing is not always effective and appropriate. There are currently no prescribing guidelines specific to this population. Aims To develop guidelines to support clinicians with their decision-making when prescribing laxatives to people with intellectual disabilities. Method A modified Delphi methodology, the RAND/UCLA Appropriateness Method, was used. Step 1 comprised development of a bespoke six-item, open-ended questionnaire from background literature and its …

Lindenwood Lions Triumph At Daytona Nca & Nda: Cheer And Dance Titles, Catalina Corredor

Lindenlink (2012- )

No abstract provided.

The King Hygiene Project: Addressing Hygiene Poverty In College Students, Krislynn King

Honors Projects

For my Honors Project, I seek to shine a light on the topic of hygiene insecurity and investigate how it impacts the modern-day college student. In addition, I have taken physical action through a hygiene drive, marketing, and volunteering to better the lives of those who struggle with this issue regardless of whether they are a student at Bowling Green State University.

Transposable Elements Regulate Thymus Development And Function, Jean-David Larouche, Céline M Laumont, Assya Trofimov, Krystel Vincent, Leslie Hesnard, Caroline Côté, Éric Bonneil, Joel Lanoix, Chantal Durette, Patrick Gendron, Jean-Philippe Laverdure, Ellen R Richie, Sébastien Lemieux, Pierre Thibault, Claude Perreault

Faculty, Staff and Student Publications

Transposable elements (TEs) are repetitive sequences representing ~45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTECs). In this study, we investigated the role of TEs on T-cell development in the thymus. We performed multiomic analyses of TEs in human and mouse thymic cells to elucidate their role in T-cell development. We report that TE expression in the human thymus is high and shows extensive age- and cell lineage-related variations. TE expression correlates with multiple transcription factors in all cell types of the human thymus. Two cell types express particularly broad TE repertoires: …

Recent Advances In Nanomaterial-Based Biosensor For Periodontitis Detection, Mohammad Hosseini Hooshiar, Masoud Amiri Moghaddam, Mohammad Kiarashi, Athraa Y Al-Hijazi, Abbas Fadel Hussein, Sara Salari, Hassan Mesgari, Saman Yasamineh

Faculty, Staff and Student Publications

Periodontitis, a chronic inflammatory condition caused by bacteria, often causes gradual destruction of the components that support teeth, such as the alveolar bone, cementum, periodontal ligament, and gingiva. This ultimately results in teeth becoming loose and eventually falling out. Timely identification has a crucial role in preventing and controlling its progression. Clinical measures are used to diagnose periodontitis. However, now, there is a hunt for alternative diagnostic and monitoring methods due to the progress of technology. Various biomarkers have been assessed using multiple bodily fluids as sample sources. Furthermore, conventional periodontal categorization factors do not provide significant insights into the …

Academic Detailing As A Health Information Technology Implementation Method: Supporting The Design And Implementation Of An Emergency Department-Based Clinical Decision Support Tool To Prevent Future Falls, Douglas A Wiegmann

Faculty, Staff and Student Publications

BACKGROUND: Clinical decision support (CDS) tools that incorporate machine learning-derived content have the potential to transform clinical care by augmenting clinicians' expertise. To realize this potential, such tools must be designed to fit the dynamic work systems of the clinicians who use them. We propose the use of academic detailing-personal visits to clinicians by an expert in a specific health IT tool-as a method for both ensuring the correct understanding of that tool and its evidence base and identifying factors influencing the tool's implementation.

OBJECTIVE: This study aimed to assess academic detailing as a method for simultaneously ensuring the correct …

Advanced Nano-Drug Delivery Systems In The Treatment Of Ischemic Stroke

Faculty, Staff and Student Publications

In recent years, the frequency of strokes has been on the rise year by year and has become the second leading cause of death around the world, which is characterized by a high mortality rate, high recurrence rate, and high disability rate. Ischemic strokes account for a large percentage of strokes. A reperfusion injury in ischemic strokes is a complex cascade of oxidative stress, neuroinflammation, immune infiltration, and mitochondrial damage. Conventional treatments are ineffective, and the presence of the blood-brain barrier (BBB) leads to inefficient drug delivery utilization, so researchers are turning their attention to nano-drug delivery systems. Functionalized nano-drug …

Affinity: A Celebration Of Community Through Poetry, Evan A. Gates

Student Scholar Showcase

The language of poetry extends far beyond the creative writing classroom; song lyrics, Bible verses, instruction manuals, and even advertisements utilize the power of words to portray a message. Like an art portrait, everyone’s unique perception helps to create a larger sense of unity through diversity. Poets emphasize the many ways culture constructs varying opinions amongst the human race. At the University of Lynchburg, people of many different demographics share one common thread: the pursuit of community. Whether local or foreign, English teacher or scientist, white or black, Lynchburg is the centerpiece of intellectual curiosity. While the school remains situated …

Praise In The Collegiate Classroom: How Narcissism, Entitlement, Empathy, And A Desire For Fame Impact Student’S Preferences For Praise, Alexandra Crissman

Student Scholar Showcase

The purpose of this study was to examine the relationship between personality traits, namely narcissism, entitlement, empathy, and a desire for fame, and a preference for public praise in a student population. Past research has shown that those who are higher in narcissism are also higher in entitlement and that these rates have been rising with future generations. Past research has also indicated a negative relationship between narcissistic tendencies and empathy, inferring that those higher in narcissism tend to score lower on empathy measures. In this study, undergraduate students were surveyed online to determine scores on four measures of traits …

Recognizing Traps And Frightening Wolves: Foxes And Lions As A Representative Of Machiavellian Political Ideology In Shakespeare’S Comedies, Grace A. Powell

Student Scholar Showcase

While William Shakespeare’s plays and sonnets have been discussed time and time again over the past few centuries, one topic that has been less traversed is the connection between his Comedies and Niccolò Machiavelli’s political ideologies. This project will explore references of lions and foxes in Shakespeare’s Comedies and the leaders and monarchs within them to determine how beliefs about Machiavelli’s political ideology influenced Shakespeare’s literature and became symbols for leadership and power. This project will be important for gaining historical context on Machiavellian political discourse and how it was represented in the contemporary dramatic literature of William Shakespeare. I …

East Vs. West And Its Relationship With Violence Among College Students And Myanmar, Bryce Davis

Student Scholar Showcase

With over 10 million men and women being targeted by domestic violence every year it has increased the need for research on the issue. Previous research has been conducted on how various crimes involving interpersonal violence can occur. The current study looks to expand on this previous research by assessing how interpersonal violence can occur. The study examines Eastern and Western cultures and how they can impact interpersonal violence. Previous research has shown that people born in eastern countries such as Asia have more of an acceptance of dating violence and rape. One hundred and thirty-six participants participated in the …

Birds Of Society: Applying External Adjustments And Conceptual Metaphor To The Importance Of Being Earnest, Morgan Forehand

Liberty University Research Week

Despite the fact that music is commonly described as free therapy with easily accessible content in the modern age of streaming, most people do not realize that music they already listen to contains many legitimate, psychologically tested therapy. This creative artistic research study examines the role that music therapy processes and techniques play in affecting the form, songwriting and creative processes of the modern music industry. These foundational aspects of songs elicit neurological responses, the emotional effect of which is discussed and incorporated through creative research and implementation through a creative artifact. This study explores songwriting techniques found in various …

Critical Raw Material In Mineral Elements Found In Fly Ashes From The Czech Republic Power Plant, Agnieszka Klupa

Journal of Sustainable Mining

The economic development of EU countries is limited due to limited access to a number of mineral raw materials, which necessitates actions aimed at securing the supply of CRM. For this reason, CRMs constitute elements of particular importance for the EU. The aim of the study was to assess the content of CRMs as a potential source of REY in fly ash resulting from the coal combustion in one of the power plants in the Czech Republic. In the tested ash the main phases are: glassy phase, mullite and quartz. The chemical composition of the tested fly ashes showed dominance …

The Physiological Demands Of A Division Iii Field Hockey Goalie: A Case Study, Kayla Brady, Sarah Miller-Richards

Student Scholar Showcase

It is essential to evaluate the physiological demands of the sport of field hockey, specifically of a division III field hockey goalie. There has been limited research on this sport, let alone on the position of goalies. Some recent studies have evaluated ice hockey goalies on their anthropometrics, upper and lower body strength, power output, and aerobic capacity. The purpose of this study was to examine the physiological demands and performance profile of a division III field hockey goalkeeper. A division III goalie went through several baseline tests including anthropometrics, resting and maximum heart rate, upper and lower one rep …

Conscious Ai And The Climate Crisis, Griffin Kiegiel

Midwest Ethics Symposium

No abstract provided.

Experience Machines And Experiencing Machines, Patrick Mckee

Midwest Ethics Symposium

No abstract provided.

The Dance Of Dismissal: A Program Oral Interpretation, Lindsay Anton

Liberty University Research Week

Drawing from prose, poetry, drama, and news articles, a ten-minute performance centered around a unifying theme was curated. This type of performance is called a Program Oral Interpretation (POI). A POI is crafted to show the skills of interweaving diverse literary genres into a cohesive performance. This performance piece is attempting to answer a question, “How can diverse performance techniques be developed to convey the emotional impact of women's misdiagnosis and dismissal of physical pain, thereby reflecting broader societal attitudes towards women's health?” This piece skillfully leverages historical context and recent studies to show the mistreatment of women in the …

Gsr Analysis: The Importance Of Viable Swab Kits, Abbye Morgan

Liberty University Research Week

Since the late 1970s, forensic scientists have been using scanning electron microscopy to analyze gunshot residue particles to determine whether an individual or object was in the vicinity of a shooting. GSR particles are from the primer of a gun, and when the gun is fired that primer will also come out of the gun and land on the shooter’s hand and objects around them. When an object or a person is swabbed and tested for GSR, forensic scientists are looking for three elements: lead, barium, and antimony. If these elements are found, the object or person is considered positive …

Accessing Advanced National Supercomputing And Storage Resources For Computational Research, Ramazan Aygun

All Things Open

This presentation will cover ACCESS (Advanced Cyberinfrastructure Coordination Ecosystem: Services & Support), and Kennesaw State University's involvement in Open Science Data Federation program as a data origin to help researchers and educators with or without supporting grants to utilize the nation’s advanced computing systems and services. ACCESS, a program established and funded by the National Science Foundation, is an ecosystem with capabilities for new modes of research and further democratizing participation. The presentation covers how to apply for allocations on ACCESS. The last part of the presentation will briefly explain Open Science Data Federation and Kennesaw State University's involvement as …

Altering The Composition Of Lanconide Fingerprint Powder, Lydia Buxa

Liberty University Research Week

Latent fingerprints found on crime scenes cannot be seen with the naked eye and require development techniques for visualization and analysis (1). Because fingerprints are composed of oily sebaceous secretions, powders used in dusting adhere to the fingerprint oils (2). The fine powder particles help visualize the print increasing contrast of the ridges and minutiae. The most common fingerprint powder is a black powder made of carbon black or powdered acacia. The composition of black powder is far more researched, but the limitation of this powder comes when the latent prints are found on dark surfaces (1). Since black powders …

Efficient Synthesis Of 5,6-Fused Ring Pyridazines For Advanced Organometallic Semiconductor Applications, David Johnson

Liberty University Research Week

Organometallic semiconductors have emerged as pivotal components driving technological innovations in recent years. With a rich history in chemistry, organometallic compounds have gained prominence for their semiconductive properties, leading to significant advancements in fields such as optoelectronics and materials science. This study focuses on streamlining the synthesis of 5,6-fused ring pyridazines, a critical organic building block for cutting-edge organometallic semiconductor technologies. Pyridazines, characterized by a six-membered aromatic ring with adjacent nitrogen atoms, exhibit remarkable stability and have diverse applications in optoelectronics and pharmaceuticals. The primary objective of this research is to develop a more efficient process for the synthesis of …

Crispr Cas9 Mediated Gfp Tagging Of Cd79a In Danio Rerio, Asia Eskaros

Liberty University Research Week

Danio rerio, commonly known as zebrafish, are well known to have an immune system that mirrors the human immune system. As such, Danio rerio is an excellent biological model for studying the immune system. This research team was attempting to study the activity of B-cells in the immune development of zebrafish. However, the team found that the exact location of B-cells in zebrafish throughout their development is not known. Thus, this research seeks to design a protocol to identify the location of B-cells throughout Danio rerio immune development. The team will be fulfilling this aim by tagging CD79a, also known …