Digital Commons Network^™

Acute Hepatitis B Infection In A Patient With Confirmed Immunity On Long-Acting Cabotegravir/Rilpivirine, William K B Boateng, Neil Carlin, Etan Spira, Maria E Szabela, Kosisochukwu J Ezeh

Faculty and Staff Publications

Long-acting injectable formulation of cabotegravir/rilpivirine (CAB/RPV) is a promising novel maintenance therapy for HIV infection. However, coinfection with active hepatitis B virus (HBV) infection is a contraindication to initiating this therapy. Despite guidelines, patients with HBV immunity can still contract acute HBV infection. We report a case of a 30-year-old man with HIV who transitioned from antiretroviral therapy to CAB/RPV and had confirmed HBV immunity. The patient, though asymptomatic, showed significantly elevated liver function tests (LFTs) before his monthly CAB/RPV injection. He was hospitalized and diagnosed with acute HBV infection. His LFTs improved, and he was taken off CAB/RPV and …

A Phenomenological Study Of Gender And The Leadership Of Female Academic Library Directors, Julia D. Grace Dr

Dissertations

The purpose of this phenomenological study was to explore how the gender of female academic library directors affects their leadership. The theory guiding this study was Acker’s theory of the ideal worker, as it offers a framework for examining the impact of worker gender in the workplace. The central research question of this study examined how the gender of female library directors at medium nonprofit private universities and colleges in the U.S. affected their leadership. This study utilized a phenomenological approach, conducting semi-structured interviews of female academic library directors at medium nonprofit private universities and colleges in the U.S. The …

Assessing Best Practices Of Facilitation Of The Free Exercise Of Religion By Army Chaplains Utilizing The Success Case Method, Geoffrey N. Bailey Phd

Dissertations

This mixed-methods study examined how U.S. Army chaplains experience and facilitate the free exercise of religion. The research explored compelling narratives of best-case facilitation experiences, identified leadership qualities associated with successful religious support, and analyzed similarities and differences between best and worst-case scenarios. Using Brinkerhoff's Success Case Method, the study distributed a quantitative survey to 1,478 active-duty chaplains (achieving a 23% response rate) followed by twelve guided interviews with participants representing diverse ranks and faith traditions. The research revealed six major themes: significant gaps in education for pluralistic ministry, tension between personal religious convictions and professional duties, crucial impact of …

Homeostatic Influence Of Fig4 Outside Of The Fab1-Vac14-Fig4 Complex In Saccharomyces Cerevisiae, Hannah E. Reeves, Anna King, Imran Khan, Asha Thomas, Corey Chung, Anirudan Sivaprakash, Harrison A. Hall, Cole Mcguire, Victoria Cruz, Alim Habib, Lauren Dotson, Sophia R. Lee, Caroline L. Darbro, Bethany S. Strunk

Biology Faculty Research

The lipid phosphatase Fig4 is conserved in all eukaryotes and is associated with human neurological diseases for which there are currently no specific therapies. Fig4 functions in both the production and turnover of its lipid substrate, PI3,5P2, through participation in the Fab1-Vac14-Fig4 complex with its opposing kinase Fab1. The molecular mechanisms through which Fig4 influences PI3,5P2 production are not fully understood but are believed to require Fig4 binding to the scaffold protein Vac14. We unexpectedly found that multiple Fig4 disease-related mutants that are impaired in binding to the Fab1-Vac14-Fig4 complex dominantly confer tolerance to rapamycin, an inhibitor of the Target …

Multi-Scale Computational Mechanical Modeling Of Complex Multi-Phase Materials Systems, Naji Al-Mashrafi

Theses and Dissertations--Chemical and Materials Engineering

This thesis employs finite-element–based computational methods to investigate how microstructural features and material heterogeneity govern mechanical behavior across three distinct complex systems. First, the elastic response of open-cell metallic foams is analyzed using large ensembles of model RVEs generated with the Kentucky Random Structures Toolkit (KRaSTk); finite-element homogenization reveals that effective stiffness is not dictated by relative density alone, as the skewness of ligament-length distributions—captured by the second Pearson’s coefficient—exerts a strong and previously unrecognized influence, with structures enriched in short load-bearing ligaments exhibiting consistently higher stiffness even at fixed density and connectivity. The second study examines heterogeneous polycrystalline solids …

The Integration Of Big Data In Fintech: Review Of Enhancing Financial Services Through Advanced Technologies, Soudeh Pazouki, Mohammad B. Jamshidi, Mirarmia Jalali, Arya Tafreshi

Management Faculty Publications

Big data analytics is revolutionizing the FinTech industry, offering new opportunities for real-time decision-making, personalized financial services, and improved risk management. By leveraging advanced technologies like machine learning and artificial intelligence, financial institutions can efficiently detect fraud, predict market trends, and create innovative solutions tailored to customer needs. Big data also plays a critical role in promoting financial inclusion through alternative credit scoring models, providing access to credit for underserved populations and fostering broader participation in the financial system.

However, the integration of big data into FinTech is not without its challenges. Issues such as data privacy concerns, regulatory complexities, …

Metallic Nanoparticles And Cosmetics: The Role Of Mitochondria And Premature Aging, Veronica Montesinos-Cruz, Justin Olmanson

Department of Teaching, Learning, and Teacher Education: Faculty Publications

The cosmetic industry has developed and commercialized numerous products using new technologies, making them increasingly appealing to the public. The use of metallic nanoparticles (MtNPs) as key ingredients in cosmetics has become more widespread due to their demonstrated benefits. However, the use of these products remains controversial, as some studies have shown that MtNPs can penetrate the deeper layers of the skin and disrupt homeostatic balance. It has also been demonstrated that the interaction between MtNPs and keratinocytes increases the generation of reactive oxygen species (ROS), which can lead to oxidative stress, a condition associated with premature aging. Mitochondria, as …

The Implementation And Use Of Intimacy Coordinators In Motion Picture Productions, John J. Chung, Pia Piscitelli

Fordham Intellectual Property, Media and Entertainment Law Journal

No abstract provided.

A Knowledge-Based Planning Model To Identify Fraction-Reduction Opportunities In Brain Stereotactic Radiotherapy, Shane Mccarthy, William St. Clair, Damodar Pokhrel

Radiation Medicine Faculty Publications

Objective: To develop and validate a HyperArc-based RapidPlan (HARP) model for three-fraction brain stereotactic radiotherapy (SRT) plans to then use to replan previously treated five-fraction SRT plans. Demonstrating the possibility of reducing the number of fractions while achieving acceptable organs-at-risk (OAR) doses with improved target biological effective dose (BED) to brain lesions. Methods: Thirty-nine high-quality clinical three-fraction HyperArc brain SRT plans (24–27 Gy) were used to train the HARP model, with a separate 10 plans used to validate its effectiveness. Fifty-eight five-fraction HyperArc brain SRT plans (30–40 Gy) attempted to be retrospectively replanned for three fractions scheme using the HARP …

An Investigation Into The Feasibility And Efficacy Of Stereotactic Radiosurgery For 1–3 Cm Single Brain Lesions On The Ring-Mounted Halcyon Linac, Kristin J. Hazelwood, Shane Mccarthy, Josh Misa, David Castelvetere, William St. Clair, Damodar Pokhrel

Radiation Medicine Faculty Publications

Purpose: An evaluation of the accuracy, safety, and efficiency of the Halcyon ring delivery system (RDS) for stereotactic radiosurgery (SRS) treatment to relatively small (1–3 cm) brain lesions.

Methods: After completing the extensive in-house quality assurance checks including Winston–Lutz test and independent dose verification via MD Anderson IROC SRS head phantom irradiation on Halcyon, fifteen brain SRS patients previously treated with a single dose of 20 Gy on TrueBeam (6MV-FFF) with HyperArc geometry were retrospectively replanned on Halcyon (6MV-FFF). Plan quality metrics including conformity index (CI), gradient index (GI), gradient distance (GD), PTV coverage, gross tumor volume (GTV) dose, heterogeneity …

A Predictive Quality Assurance Model For Patient-Specific Gamma Passing Rate Of Hyperarc-Based Stereotactic Radiotherapy And Radiosurgery Of Brain Metastases, Shane Mccarthy, Brent Harrison, Damodar Pokhrel

Radiation Medicine Faculty Publications

Objective: Measurement-based patient specific quality assurance (PSQA) is an increasingly debated topic among medical physicists. Developments like online adaptive radiotherapy and same-day stereotactic treatments limit the time to do measurement-based PSQA. Herein, we develop a predictive machine learning model to supplement PSQA by predicting the gamma passing rate (GPR) per stereotactic arc. This streamlines PSQA, providing planners the insight to replan potentially sub-optimal plans, to mitigate machine time inefficiencies.

Methods: 122 patients that had previously received HyperArc stereotactic radiosurgery/radiotherapy on a TrueBeam LINAC (Millenium 120 MLCs, 6MV-FFF) were used to generate a long short-term memory (LSTM) recurrent neural network to …

Automated Hippocampal Sparing Whole Brain Radiotherapy With Simultaneous Integrated Boost For Multiple Brain Metastases: Halcyon, Hyperarc On Truebeam, And Coplanar Truebeam, Shane Mccarthy, Ryan Clark, Anthony Magliari, William St. Clair, Damodar Pokhrel

Radiation Medicine Faculty Publications

Purpose: To demonstrate the ease and feasibility that hippocampal sparing whole brain (WB) simultaneous integrated boost (HSWB-SIB) plans can be generated using knowledge-based planning and Eclipse Scripting Application Programming Interface (ESAPI) for three different modalities, HyperArc on TrueBeam (TB-HA), a coplanar beam arrangement on TrueBeam (TB-Co), and the ring-mounted Halcyon LINAC (Hal).

Methods: Twelve patients with 2–14 brain metastases were retrospectively replanned for HSWB-SIB using a published HSWB RapidPlan model with modifications for the automated addition of SIB to metastases. Prescribed dose was 30 Gy to the WB planning target volume (PTV) and 50 Gy to the metastases in 10 …

Feasibility Of Treatment Planning With Hyperarc Stereotactic Radiosurgery Methods For Ocular Tumors, Chase Cochran, Shane Mccarthy, William St. Clair, Damodar Pokhrel

Radiation Medicine Faculty Publications

Purpose/objectives

Currently, ocular disease is primarily managed with COMS plaque brachytherapy. Various stereotactic radiosurgery (SRS) platforms have also been employed, yet widespread access remains a challenge. Herein, we demonstrate the feasibility of using the HyperArc SRS system to provide an additional platform for the treatment of ocular malignancies.

Materials/methods

Twenty previously treated COMS patients with ocular melanoma were selected for a retrospective HyperArc SRS planning study. The average gross tumor volume (GTV) derived from MRI was 1.19 ± 0.60 cc. Planning target volumes (PTV) were generated from a 2 mm expansion of the GTVs. HyperArc plans were created for a …

The Power Of Digital Place-Based Pedagogy Through Hip Hop: Khmer 1jivit’S “A Distressed Society” On Youtube, Sophea Seng

Humboldt Journal of Social Relations

"This essay is an exercise in my own Cambodian American memory work. When I saw the collage of images of “A Distressed Society” on YouTube, I was struck by how the anonymous user(s) paired the rap lyrics of Khmer 1Jivit..."

Introduction To Place-Based Digital Inquiry, Cinthya Ammerman Muñoz, Paul Michael L. Atienza, Catey Hoehn

Humboldt Journal of Social Relations

"This special issue of the Humboldt Journal of Social Relations brings together a diverse range of projects that explore how digital inquiry, when grounded in placebased approaches, can deepen local engagement while broadening the reach of community-rooted scholarship. Place-based digital inquiry integrates digital tools with relational and situated research practices..."

10 Gold Coins: Trauma-Informed Landscape Care Of Wiyot Plaza, Karley Rojas

Humboldt Journal of Social Relations

"With the initiation of the construction of the Rou Dalagurr Food Sovereignty Lab and Traditional Ecological Knowledges Institute (FSL) in October 2021 (now open), attention was given to entering into relationship with the exterior space. Students from the NAS 331: Indigenous Natural Resource Management class, which included this author, initiated an assessment..."

Sharing Indigenous Resistance Movements Through Arcgis Storymaps, Sterling Russell

Humboldt Journal of Social Relations

"The two projects featured in this article are made with a digital tool called ArcGIS StoryMap and were final project submissions for Geography 311, Geographic Research and Writing, and Native American Studies 307, Nature and Issues of Genocide. StoryMaps are one of many different resources..."

The Challenge That The Advent Of Artificial Intelligence (Ai) Tools Poses To The Procedures For Determining The Existence Of The Preliminary Facts That Condition The Admissibility Of Items Of Evidence, Edward J. Imwinkelried

Marquette Law Review

“[A]d quæstionem facti non respondent judices; . . . ad quæstionem juris not respondent juratores.” Judges do not answer questions of fact; jurors do not answer questions of law.

The jury is a central institution in the American level infrastructure. The Sixth and Seventh Amendments elevate the jury trial right to constitutional status. Of course, when a judge presides at a jury trial, the question that naturally arises is the division of decision-making labor between judge and jury. In the past few decades, the Supreme Court’s Apprendi v. New Jersey line of authority has expanded the jury’s authority to decide …

Don’T Trust The Process: The Viability Of Eighth Amendment Claims For Ultra-Processed Food Overconsumption In Prisons, Markus C. Johnson, Rita L. Rahoi-Gilchrest

Marquette Law Review

With the largest prison population worldwide, American prisons serve more food than anywhere else. To cut costs, American prisons overwhelmingly (or even entirely) serve prisoners ultra-processed foods, which, if overconsumed, have detrimental and long-lasting health effects. Prisoners taking issue with the food being served to them rely on the courts to counteract any inappropriate prison dietary practices, wielding the Eighth Amendment as a constitutional guarantee to be free from cruel and unusual punishment. But courts are failing to protect this constitutional guarantee by relying on precedent that is at odds with modern Eighth Amendment principles. Indeed, when it comes to …

Boden Lecture: Taxation Of Autonomous Artificial Intelligence, Reuven Avi-Yonah, Lucas Brasil Salama, Herbert Snitz, W. Robert Thomas

Marquette Law Review

This Article proposes that tax can be a useful supplement to other measures to regulate Autonomous Artificial Intelligence (AAI) and limit its potential harmful effects. This proposal differs from command-and-control regulation of AAI along the lines of European Union legislation that may unduly limit the development of AAI. It also differs from existing proposals to tax AAI to generate revenue to help workers displaced by AAI programs, or to tax the data used by AAI. The proposal is based on granting AAI programs like ChatGPT separate legal personhood, like corporate personhood, while incentivizing or requiring their corporate owner to place …

Substituting One Judge For Another: The Lax Standard Of Review In Involuntary Commitment, Caitlin Riordan

Marquette Law Review

Wisconsin involuntarily commits individuals at a rate nearly five times the national average, stripping them of core constitutional rights—including liberty, the ability to refuse treatment, and firearm possession. Yet, when these life-altering orders are appealed, they are almost always reviewed by a single appellate judge. This Comment argues that such a limited review undermines the constitutional weight of involuntary commitments, which closely mirror criminal convictions in the scope of rights deprived. Tracing the historical development of Wisconsin’s civil commitment statutes, this Comment demonstrates how commitments implicate both substantive and procedural due process concerns. It then compares Wisconsin’s one-judge review framework …

Tik Tok! Tiktok: Escalating Tension Between U.S. Privacy Rights And National Security Vulnerabilities, Lawrence J. Trautman

Marquette Law Review

Vastly popular short-form video provider TikTok employs personalized content algorithms for each consumer. Because TikTok is controlled by the Chinese Communist Party (CCP) of the People’s Republic of China, a legitimate question exists whether TikTok constitutes a national security risk to the West like a number of influential and successful high growth social media platforms that have been used by nation-states during recent years for propaganda and disinformation purposes. Cyberattacks upon American interests have been attributed to China, Iran, North Korea, Russia, and others. Well-documented examples of foreign activity and exploitation resulting from disruption of the U.S. elections since 2016 …

Public Private Property, Xiaoqian Hu

Marquette Law Review

Many struggles are being fought in America today around regulation and redistribution of private property rights: between owners’ right to develop land and society’s need for environmental conservation; between landlords’ privilege to charge higher rents and society’s need for affordable housing, between property owners’ desire for protection from negative effects and unhoused persons’ need to live in the only space accessible to them, etc. These struggles, however, are doomed by a widely shared notion that public and private are inherent qualities in a zero-sum game. This Article refutes this notion. Building upon Legal Realist, post-Realist, and poststructuralist insights, it argues …

Tort Law: Cases & Critique, Thomas E. Kadri

Books and Book Chapters

No abstract provided.

Answering Our Call To Care: Introduction To The Special Issue On Long Covid, Todd E. Davenport

Pacific Faculty Work

No abstract provided.

Let The Apartment Dream Itself: Territory Of Light And The Cartography Of Containment, Edgar C. Samar

Filipino Faculty Publications

No abstract provided.

Land Remembers What Bodies Forget: 'Beauty Is A Wound' And The Geography Of Colonial Haunting, Edgar C. Samar

Filipino Faculty Publications

No abstract provided.

Identification Of Pharmacophore Modifications That Enhance Bmp-Receptor Agonism, An Investigation To Understand The Development Of Potential Therapeutic Interventions, Maleka T. Stewart

Theses and Dissertations

Bone morphogenetic proteins (BMPs) are the largest subfamily of the Transforming Growth Factor (TGF)-ß superfamily. BMPs are renowned for their pivotal role in cellular functions such as cell growth, apoptosis, and differentiation. Yet, BMPs have also been attributed to the maintenance of adult tissue homeostasis. BMPs elicit physiological function at the cell membrane via a heterotetrameric complex composed of two Type I and two Type II serine-threonine kinase BMP receptors. Activation of BMP transmembrane receptors results in activation of either canonical (Smad-dependent) and/or non-canonical (Smad-independent) signaling. Given the physiological importance of this intricate communication between receptor activation and induction of …

Development Of An Honors Leadership Academy Experience, Samantha Gregus, Chelsea Redger-Marquardt, Bobby Berry, Doug Stucky, Cindi Mason, Kimberly Engber

Honors in Practice Online Archive

This essay presents a leadership academy in honors, an interdisciplinary offering co-taught by a team of five faculty combining in-course curriculum with travel-based experiential learning. Authors describe the academy’s inception, development, and curricular objectives and outcomes, as well as the experiences of four student cohorts (2021–2024). Focusing on interdisciplinary approaches to community-based problem solving, students (n ≈ 8–14) learn the Social Change Model of Leadership Development framework; engage in self-reflective exercises relating to leadership values and attitudes; partner with a local nonprofit organization; use design thinking methodology to solve a specific organizational challenge; and collaboratively work in teams to …

Corporate Scenarios: Drawing Lessons From History, Madison Condon

Seattle University Law Review

As corporations are increasingly pressed to reveal information about their exposure to climate-related risks, they are often asked to undertake and disclose the outcome of “scenario analysis.” In this exercise, corporations, including financial institutions, examine how their business would fare under different pathways the future may take. One oft-used scenario, for example, is the International Energy Agency’s “Net-Zero by 2050: A Roadmap for the Energy Sector.” This Essay presents a history of the use of scenarios as a corporate planning tool, particularly in the oil industry, arguing that it is key for understanding our present moment and the role of …