Digital Commons Network^™

The Role Of The Glycerol Metabolism Regulator Glpr On Pseudomonas Aeruginosa’S Physiology, Nicholas Jordan Evans

All ETDs from UAB

Chronic infections with Pseudomonas aeruginosa are a leading cause of morbidity and mortality in people with cystic fibrosis. P. aeruginosa persists in the CF lung through adaptations, including altering the expression of metabolic genes to acquire nutrients that are abundant in the CF airway. Glycerol in the airway is imported and metabolized by proteins encoded in the glp regulon, which is regulated in part by GlpR. The loss of GlpR was previously shown to increase biofilm development in a P. aeruginosa CF isolate compared to a wound isolate. In the first half of this work, we investigated the influence that …

Investigating The Role Of Fibroblast Growth Factor Signaling In The Cystic Fibrosis Airways, Meghan June Hirsch

All ETDs from UAB

Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene which results in complications in organs such as the lung, pancreas, liver, and intestines. In the lung, defective CFTR results in thick, sticky mucus that causes susceptibility to colonization of opportunistic pathogens such as Pseudomonas aeruginosa (PA), progressive lung damage, and ultimately a decrease in life expectancy in affected individuals depending on severity of disease. Additionally, one of the characteristics of this disease, with and without PA infection, is chronic inflammation. Chronic inflammation has also been associated with accelerated aging …

Compartmentalized Antigen Presentation By Intestinal Epithelial Cells Directs Cd4 T Cell Fate, Christopher Garrett Wilson

All ETDs from UAB

The intestinal epithelium maintains a complex relationship with both commensal microbiota and enteric pathogens while orchestrating local immune responses. Although intestinal epithelial cells (IECs) can express MHC class II molecules during inflammation, their functional contribution to pathogen-specific adaptive immunity and immunological memory remains poorly defined. This dissertation investigates the hypothesis that IECs actively shape CD4+ T cell responses through antigen presentation, using Citrobacter rodentium infection as a physiologically relevant model of human attaching and effacing bacterial pathogens. The C. rodentium model offers unique advantages for dissecting epithelial-immune interactions: it naturally infects mice through oral inoculation, exhibits precise anatomical tropism for …

Air Pollution And Environmental Injustice Are Related To Respiratory Complications In Individuals With Sickle Cell Disease, Kelsey M. Maclin

All ETDs from UAB

Sickle cell disease (SCD) is a genetically inherited blood disorder affecting people of African descent. SCD is characterized by painful episodes and an acute lung injury known as acute chest syndrome (ACS). Patients with SCD have a life expectancy <19 years compared to Blacks without SCD. There is minimal research investigating air pollution and health complications in SCD. The aims of this research were to investigate whether pulmonary function is affected by exposure to ambient air pollution, whether higher air pollution concentrations are associated with hospitalizations for ACS, and whether environmental injustice impacts the respiratory health of children and young adults with SCD. Air pollution data on the criteria air pollutants (CAPs) was obtained from the US Environmental Protection Agency (EPA). Patient health data were obtained from Children’s Hospital of Alabama electronic medical records. Logistic regression, distributed lag non-linear regression, Granger Causality, and Getis-Ord Gi* hot spot analysis were used to analyze our data. The EPA’s EJScreen tool was used as a measure of exposure to environmental injustice. ArcGIS was used to map the EJScreen data. Exposure to short-term air pollution is significantly associated with a reduction in pulmonary function in children and young adults with SCD. Children and young adults exposed to a one-unit increase in the monthly average concentrations of sulfur dioxide (SO2) experienced an increase in the odds of having abnormal pulmonary function. We observed the trends of each criteria air pollutant in our study to be closely aligned with the trends in the hospitalizations for ACS. Most of our study participants with a history of ACS lived in areas burdened by greater environmental injustices. Specifically, the hot spots for ACS overlapped with the hot spots for PM2.5. Unequal exposure to environmental injustices leads to increases in hospitalizations for respiratory complications in individuals with SCD. Reductions in air pollution could be greatly beneficial to the pulmonary function and overall respiratory health of individuals with SCD. Further research is needed to examine associations between air pollution and hospitalizations for ACS in individuals with SCD.

Core Body Temperature (Cbt) Monitoring Among Groundskeepers Under Heat Stress, Lara Anne Parker

All ETDs from UAB

Heat is the leading cause of death for outdoor workers. In Alabama, there are an estimated 11,160 - 21,460 workers employed in the landscaping and groundskeeping industry, which are vulnerable to heat-related illnesses (HRI). In this study, core body temperature (CBT) and wet-bulb globe temperature (WBGT) index were examined as potential indicators of heat stress. A SlateSafety (SS) Band V2 wearable CBT device and a WBGT monitor were used to collect CBT and WBGT values, respectively. Sampling for the main two measurements was performed over five days for two participants. An additional CBT device option, the e-Celsius performance ingestible pill, …

Voices From Two Secondary Newcomer Programs In Alabama: A Multiple Case Study, Carl Anthony Floyd Jr

All ETDs from UAB

This multiple case study investigates the design, implementation, and impact of two secondary newcomer programs in Alabama, with a focus on Students with Limited or Interrupted Formal Education (SLIFE) and non-SLIFE English Learner (EL) newcomers. Grounded in Esteban-Guitart et al.’s (2023) framework of community funds of knowledge and identity, the study explores how these programs function as community educational ecosystems. Data were collected through interviews, observations, and document reviews across two school districts and analyzed using ethnographic and thematic methods. Findings reveal that when newcomer programs are intentionally designed to leverage community assets and cultural identities, they provide meaningful academic, …

The Impact Of Nursing Home Ownership On The Election Of Advance Care Directives, Natasha Elie

All ETDs from UAB

Approximately 1.3 million people reside in nursing homes/facilities. Annually, this population represents 25% of mortalities in the United States. The enactment of the Patient Self Determination Act (PSDA) required nursing homes/facilities to educate patients, staff, and the community on the right to advance care directives. This study aimed to evaluate the impact of nursing home ownership on the election of ACDs and end-of-life care services by examining how nursing homes ownership in New York, California, and Ohio compared regarding residents' election of ACD and whether there was a variation in the these states. This paper contributes to the literature by …

Racial Discrimination And Inflammation In Adolescence: Ethnic/Racial Processes As Moderators, Queenisha Crichlow

All ETDs from UAB

Discrimination and other psychosocial stressors contribute to chronic disease by dysregulating neuroendocrine and immune systems, which often leads to increased levels of inflammation. Given that inflammation is a key biological pathway associated with the development of chronic diseases, it has been proposed as a potential mechanism linking racial discrimination to poorer health. Most studies linking racial discrimination with inflammation have focused on adults, despite the fact that children and adolescents also experience discrimination. This dissertation explores the association between racial discrimination and inflammation, measured via salivary C-reactive protein (CRP) and proinflammatory cytokines, among Black and Hispanic adolescents. It also examines …

Probiotic Biogeography In The Neonatal Intestine, Sierra Hansen

All ETDs from UAB

Neonatal infection remains a leading cause of both neonatal morbidity and mortality worldwide, particularly in preterm infants. Probiotic bacteria have been demonstrated to protect against the development of neonatal intestinal dysbiosis, however, formulations and efficacy vary substantially, highlighting a critical gap in the current understanding of the mechanisms governing probiotic efficacy in this population. This gap is exacerbated by regulatory standards which favor economic expansion over scientific rigor. Furthermore, current studies on probiotic efficacy largely rely on indirect or relative readouts of intestinal bacterial burden. Herein, we directly quantify the probiotic effects of Ligilactobacillus murinus V10 and Escherichia coli Nissle …

Understanding Clinical Tool Adoption In Primary Care: A Case Study Of The Cmds Care Pathway, Khushbu Khatri Park

All ETDs from UAB

The rising prevalence of obesity, diabetes, and cardiovascular disease (CVD) places increasing strain on healthcare systems and primary care providers (PCPs). In response, the University of Alabama at Birmingham (UAB) adapted the Cardiometabolic Disease Staging System (CMDS), a validated clinical decision support tool, designed to stratify patient risk and guide evidence-based treatment. Embedded within the electronic health record (EHR) as a Care Pathway, the CMDS was designed for real-time use during primary care visits. This dissertation examines utilization of the CMDS in a two-phase case study, guided by the Adult Learning Theory, Group Dynamics Theory, Force Field Theory and Change …

Bridging The Gap: Exploring The Facilitators And Barriers In The Self-Management Of Diabetes And Pain In Rural Southern Communities, Kennedy Nicole Butler

All ETDs from UAB

Southern rural communities experience a higher prevalence of Type 2 diabetes (T2D) and associated comorbidities, which increases rates of premature mortality due to socio-environmental factors, pre-existing health conditions, and economic burden in comparison to their urban counterparts. Fifty percent of individuals with T2D experience pain or chronic pain (CP); however, individuals in rural communities disproportionately experience symptoms of CP. CP is a physically debilitating condition that can inhibit mobility and reduce quality of life. T2D and the co-occurrence of CP can limit an individual's ability to engage in self-managing behaviors. While diabetes self-management education and support (DSMES) programs, along with …

Standardizing Sea Urchin Husbandry: Tank Effects, Gamete Production, And Co-Culture, Raven Amber Edwards

All ETDs from UAB

This dissertation seeks to further knowledge of sea urchin husbandry in three major areas that have so far not been investigated substantially: optimal conditions for housing sea urchins in a lab-based recirculating aquaculture systems (RAS), impacts of repetitive spawning regimens on reproductive output, and co-culture utilizing juvenile oysters. All studies utilize a commercial recirculating aquaculture system that is relatively novel for culturing sea urchins. The first chapter investigated the influence of housing conditions on sea urchin growth outcomes. Under the conditions of this study, the size of the tank showed limited influence on growth; however, stocking density was found to …

Wellness Perspectives Of Early Career Teachers: An Exploratory Study Of School Culture And Environment, Amy Day Carr

All ETDs from UAB

Purpose: The purpose of this grounded theory dissertation was to explore Alabama early career teachers’ perceptions of personal wellness, the wellness culture and environment of their school system, and the impact of the culture on teacher wellness and job satisfaction. Early career teachers face unique challenges that contribute to high turnover rates, yet their wellness has not been systematically studied. This study sought to answer three primary research questions with sub-questions. Teachers were asked to describe their personal wellness, the wellness culture at their schools, and the effect of the wellness culture and environment of the school on teachers in …

Attitudes Of Optometrists Towards Referring Patients For Nutrition And Lifestyle Changes To Treat Diabetic Retinopathy And Age-Related Macular Degeneration, Samantha Chapman

All ETDs from UAB

Some ocular diseases, including diabetic retinopathy and age-related macular degeneration, have direct links to systemic diseases or the condition of the body as a whole. Specific diet and lifestyle changes have been studied in relation to these two diseases and, while it is not within the scope of optometry to prescribe these changes for patients, an optometrist may refer to a variety of specialists so that patients can receive the most holistic care available. The primary goal of this study is to assess the attitudes of currently practicing United States optometrists towards referring to nutrition and lifestyle professionals and their …

Spartan Daily, September 11, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 9

Winter Supplementation Of Beef Cows In The Intermountain West, David Secrist

All Current Publications

Feed costs are the most significant expense of most ranching operations in the Intermountain West. Year-round grazing opportunities, hay cost and availability, calving season, cow size, milk production, and feeding logistics are all considerations in a supplementation program. The key to effective winter feeding is to balance the cost/benefit ratio of the supplementation programs while meeting nutritional demands at a minimal cost.

The Hidden Link Between Hiv And Cardiomyopathy: Unraveling Hiv's Impact On The Heart, Toluwalase Awoyemi, Oluwaremilekun Zeth Tolu-Akinnawo, Andrew Greek, Oluwakemi Adenuga, Chukwuebuka Asogwa, Isaac Ekundayo, Olamide Odusola, Oyinlola O. Fasehun, Mercy Ajayi, Onyinye Ugoala

School of Medicine Publications

This comprehensive review examines the complex relationship between human immunodeficiency virus (HIV) and cardiomyopathy, focusing on the underlying molecular mechanisms, clinical manifestations, diagnostic approaches, and treatment strategies. It highlights the significant global health burden posed by HIV and its potential to cause long-term cardiovascular complications. The review investigates the pathogenesis of HIV-associated cardiomyopathy. It elucidates the intricate cellular and molecular pathways involved, including the actions of neutrophils, monocytes, macrophages, and lymphocytes in cardiac inflammation. Key signaling pathways such as TNF-NF-κB and the caspase-1 inflammasome are detailed, as they contribute to cardiac infection and injury. The clinical manifestations of HIV-associated cardiomyopathy …

Human Toxocariasis, Susana Lopez-Alamillo, Pravallika Padyala, Megan Carey, Megan M Duffey, Jill E Weatherhead

Faculty, Staff and Students Publications

Human toxocariasis is a globally prevalent zoonotic parasitic infection caused by larvae of Toxocara species, primarily Toxocara canis and Toxocara cati. Toxocariasis is commonly transmitted to humans through the ingestion of embryonated Toxocara eggs found in contaminated soil, water, or on surfaces contaminated with animal feces. Unlike in dogs and cats, humans are not definitive hosts for Toxocara spp., and, as a result, Toxocara larvae do not complete their life cycle in humans. Instead, following accidental oral ingestion of embryonated eggs, Toxocara larvae undergo an aberrant larval migratory cycle to various organs including the lungs, liver, muscles, and central …

Temperature And Pressure Shaped The Evolution Of Antifreeze Proteins In Polar And Deep Sea Zoarcoid Fishes, Samuel N. Bogan, Nathan Surendran, Scott Hotaling, Thomas Desvignes, Iliana Bista, Luana S.F. Lins, Mari H. Eilertsen, Nathalie R. Le François, Tait Algayer, Scott L. Hamilton, Paul B. Frandsen, Federico G. Hoffmann, Joanna L. Kelley

Faculty Research, Scholarly, and Creative Activity

Antifreeze proteins (AFPs) have enabled teleost fishes to repeatedly colonize polar seas. Four AFP types have convergently evolved in several fish lineages. AFPs inhibit ice crystal growth and lower tissue freezing point. In lineages with AFPs, species inhabiting colder environments may possess more AFP copies. Elucidating how differences in AFP copy number evolve is challenging due to the genes' tandem array structure and consequently poor resolution of these repetitive regions. Here, we explore the evolution of type III AFPs (AFP III) in the globally distributed suborder Zoarcoidei, leveraging six new long-read genome assemblies. Zoarcoidei has fewer genomic resources relative to …

Editorial: A Step-By-Step Statistical Decision Framework For A Gender-Inclusive Approach In Sport And Exercise Science Research, James W. Navalta, Dustin W. Davis, Jafra D. Thomas, Whitley J. Stone

International Journal of Exercise Science

International Journal of Exercise Science 18(1): 1010-1029, 2025. The conflation of sex and gender in sport and exercise science research has led to gaps in representation and understanding of gender-inclusive outcomes. This invited editorial presents a framework to guide researchers in conducting statistical analyses that account for multiple gender identities beyond the traditional binary classification. The invited editorial guides deliberation on whether to test for sex or gender differences in sport or exercise science research. It prompts investigators to answer the question, “Is there a valid, literature-supported rationale for investigating sex or gender differences?” If “yes”, we propose approaches that …

Translational Science Of Blended Tube Feedings, Amy Spurlock, Noah Thomas

International Nursing Research Congress (INRC)

The purpose of this research synthesis is to summarize translational science on Blended Tube Feeding (BTF) and the commentary that led to further research in the field.

Since 2013, nine papers have been published by a team on BTF. These papers utilized a variety of research methods to investigate the safety, efficacy, and patient outcomes of BTF compared to commercial formulas (CF). A case study explored the clinical improvement of a child post-transition to BTF, revealing reduced gastrointestinal (GI) symptoms and increased oral intake¹. Survey research was employed with Registered Dietitians and caregivers to assess attitudes, experiences, and …

Poor Dietary Habits And Physical Inactivity In Obese And Overweight Children: A Concept Analysis, Mahdiyeh Ahmadi, Marti Rice, Felesia Bowen

International Nursing Research Congress (INRC)

Aim: The aim of this poster is to analyze the concepts of poor dietary habits and physical inactivity, which are defined differently by various researchers, in obese and overweight school-aged children.

Background: Poor dietary habits and physical inactivity are two common modifiable lifestyle behaviors, contributing to overweight/obesity in children.

Design: Rodgers' method of concept analysis guided the review, including sample and setting, literature search, and data analysis.

Data Source: PubMed and CINAHL were searched for relevant literature.
Results: Antecedents included changes in children's lifestyles, increased dependence on transportation, parental, caregivers’, and peer influence, cultural and social norms, and environmental factors. …

Evaluation Of Practical-Based Instruction In Oncology Nursing Curriculum For College Students, Chih-Yin Chien, Tsae-Jyy Wang

International Nursing Research Congress (INRC)

Background: Vocational education not only focuses on knowledge transfer but also emphasizes practical application. The cultivation of practical-based learning is a crucial core of vocational education, balancing theory and practice while addressing students' diverse development.

Purpose: The purpose of this study was to develop an oncology nursing practice curriculum aligned with core competencies and to evaluate its effectiveness. The curriculum was designed around a practical-based learning approach, encouraging students to engage in discussions that foster learning engagement, enhance self-efficacy.

Methods: This study utilized a single-group pre-test and post-test design with a convenient sample of 27 students. The questionnaire assessed self-directed …

Nurses’ Work Interruption And Response: Medication Tasks And Difference By Nursing Delivery System, Kyung Jin Hong

International Nursing Research Congress (INRC)

Purpose: Work interruption is a major factor that increases nurses’ workload, and multitasking during medication tasks is associated with medication errors. This study aimed to report the frequency, source, and response of interruptions during work, focusing on medication tasks and the differences between functional nursing and integrated team nursing delivery systems.

Methods: This study was conducted in August 2023 in two wards operating under different nursing delivery systems in a general hospital in South Korea. The observers shadowed each nurse individually, monitoring their work hours; 12 shifts (five day and seven evening shifts) for the functional nursing …

The Cost Of Malnutrition In Older Adults In The Mountain West, 2020, Taylor Volk, Anirudh Polagani, Olivia K. Cheche, Kristian Thymianos, Caitlin J. Saladino, William E. Brown Jr.

Health

This fact sheet presents 2020 data on the annual costs of disease-associated malnutrition for adults aged 65 years and older across the five Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah. The data are sourced from “Advancing Policies for Quality Malnutrition Care in Older Adults: A Toolkit for State Legislators,” a report published by Defeat Malnutrition Today and Women in Government.

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

How Climate Change Disrupts Mango Phenology And Affects Fruit Production, Andi Siady Hamzah, Putu Oka Ngakan, Kaimuddin Kaimuddin, Nasri Nasri, Putu Supadma Putra, Wardiman Mas'ud

Jurnal Penelitian Kehutanan Wallacea

Climatic elements are limiting factors for plants; therefore, climate change can impact the phenology of plants. This study aims to determine the impact of climate change on the reproductive phenology of four local mango cultivars on Sulawesi Island, Indonesia. Data were collected during 2013 and 2014 by observing and recording the production of vegetative shoots, generative shoots, and fruits from the trees of each mango cultivar weekly. To assess the impact of seasonal change on fruit quality, the weight and sugar level of the ripe fruits in each cultivar were measured. Climate data were obtained from the National Centers for …

Analysis Of The Carrying Capacity Of Proboscis Monkey Habitat On Bakut Island, South Kalimantan, Based On Leaf Area Index, Abdi Fithria, Rina Kanti, Arfa Agustina Rezekiah, Syamani D Ali, Eva Prihatiningtyas, Noor Aida Azizah, Eko Budi Setiawan, Ahdiyaka Jayasukma Pribadi, Naufal Noor Kamil

Jurnal Penelitian Kehutanan Wallacea

Bakut Island is one of the conservation forest areas in South Kalimantan. This island is the habitat of proboscis monkeys, and the proboscis monkey population is increasing from year to year. Therefore, it is estimated that one day the proboscis monkey habitat on Bakut Island will be over capacity. This study aims to estimate how long the population of proboscis monkeys on Bakut Island Nature Tourism Park can survive there by examining the amount of food the island's vegetation can produce. Proboscis monkey feed itself is estimated using the Leaf Area Index (LAI). LAI was extracted using UAV imaging and …

Policy Recommendations To Reduce Old Age Food Insecurity In The United States, Colleen M. Heflin, Madonna Harrington Meyer

Center for Policy Research

In 2023, 7.4 million adults ages 60 and over in the United States were food insecure. As the number of older people at risk of food insecurity in the U.S. continues to rise, effective policy responses are critical. The current policy responses to old age food insecurity are complex, costly, and not nearly effective enough.

Based on the book, Food for Thought: Understanding Older Adults Food Insecurity, this brief summarizes five policy recommendations to improve food insecurity among U.S. older adults. The authors recommend measuring food security in multidimensional ways, treating food insecurity as a health issue, adopting SNAP …

Bearing Witness: Témoignage As A Tool For Child Advocacy During Armed Conflict., Anik Patel, Amber Alayyan, Heather A. Haq, Parminder S. Suchdev, Naji Hattar, Jeffrey Goldhagen, David J. Schonfeld, Tanya Haj-Hassan, Lia Harris, Seema Jilani, Ayesha Kadir, Paul H. Wise, Lisa Umphrey

Manuscripts, Articles, Book Chapters and Other Papers

Children affected by armed conflict suffer devastating physical, emotional, and social harm. War uproots families, forcing many to flee as refugees or internally displaced persons, while others remain trapped in dangerous environments. In these crises, children face disproportionate risks-violence, exploitation, disrupted education, and collapsed healthcare systems. Their unique vulnerabilities require urgent, targeted action to protect their health, rights, and development. Beyond immediate care, the humanitarian principle of témoignage-bearing witness-is essential. Rooted in humanitarian ethics, témoignage means speaking out about injustice, amplifying the voices of those affected, and driving systemic change. It challenges traditional notions of neutrality and calls on humanitarian …