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Dietary Patterns For Weight And Glycemic Management In Persons With Type 1 Diabetes: A Meta-Analysis Of Clinical Trials, Daria Igudesman, Laura M Nally, Alyssa A Grimshaw, Craig G Gunderson, Elizabeth G Considine, Laura M Jacobsen, Mustafa Tosur, Peter A Gottlieb, Irl B Hirsch, Lori M Laffel, Jennifer L Sherr, Chantal Mathieu, Richard E Pratley Oct 2025

Dietary Patterns For Weight And Glycemic Management In Persons With Type 1 Diabetes: A Meta-Analysis Of Clinical Trials, Daria Igudesman, Laura M Nally, Alyssa A Grimshaw, Craig G Gunderson, Elizabeth G Considine, Laura M Jacobsen, Mustafa Tosur, Peter A Gottlieb, Irl B Hirsch, Lori M Laffel, Jennifer L Sherr, Chantal Mathieu, Richard E Pratley

Children’s Nutrition Research Center Staff Publications

Background: Medical nutrition therapy is fundamental for managing glycemia and weight in type 1 diabetes, yet dietary guidance specific to this population and relevant subgroups is lacking.

Purpose: We synthesized the interventional literature investigating diet patterns for glycemic and weight management in youth and adults with type 1 diabetes, with attention to interindividual variation that suggests the need for precision approaches. The protocol was prospectively registered (CRD42024519941).

Data sources: AMED, CINAHL, Cochrane Library, Ovid MEDLINE, Ovid Embase, Google Scholar, and Web of Science Core Collection were searched from January 2011 to June 2024.

Study selection: Clinical trials ≥4 weeks with …


Clinical Management Of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome As A Curriculum Thread To Meet Accreditation Standards In Physical Therapy Education, Sallie W. Rediske, Heidi Shearin, Todd E. Davenport, Melinda W. Maxwell Oct 2025

Clinical Management Of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome As A Curriculum Thread To Meet Accreditation Standards In Physical Therapy Education, Sallie W. Rediske, Heidi Shearin, Todd E. Davenport, Melinda W. Maxwell

Internet Journal of Allied Health Sciences and Practice

Purpose: ME/CFS is a debilitating, complex, chronic illness that is estimated to affect up to nine million Americans. It requires a paradigm shift in treatment approach to one of energy conservation due to metabolic effects resulting in exercise and activity intolerance. Including clinical management of ME/CFS as a curriculum thread in Doctor of Physical Therapy (DPT) programs is vital for safe and effective care of people with ME/CFS and can help meet accreditation standards. Methods: ME/CFS significantly impacts quality of life. It has been recognized by the World Health Organization since 1969 as a biomedical neurological disorder. Prior to …


Unraveling The Impact Of Spider Cage Therapy On Static And Dynamic Standing Balance In Children With Spastic Diplegic Cerebral Palsy: A Randomized Clinical Trial, Varsha Anbu, Senthil Kumar Natarajan, Jagatheesan Alagesan, Akshaya Venkat, Rekha Chitrada Oct 2025

Unraveling The Impact Of Spider Cage Therapy On Static And Dynamic Standing Balance In Children With Spastic Diplegic Cerebral Palsy: A Randomized Clinical Trial, Varsha Anbu, Senthil Kumar Natarajan, Jagatheesan Alagesan, Akshaya Venkat, Rekha Chitrada

Internet Journal of Allied Health Sciences and Practice

Purpose: The intent of this study was to ascertain the efficacy of spider cage therapy for static and dynamic standing balance in children with spastic diplegic cerebral palsy using Pediatric Balance Scale (PBS) and Gross Motor Function Measure (GMFM). Cerebral palsy described as a group of disorders with uneven posture and movement were spastic diplegia is the most prevalent type. Method: This study was a randomized controlled trial that used random sampling and blinded evaluators. Children with diplegic CP aged between 5 and 10 years, with GMFCS levels II-IV, were assigned to spider cage therapy group and conventional …


Evaluating The Self-Efficacy Of Novice Educators In Nursing And Allied Health Care Programs As It Pertains To Faculty Development, Amanda Doneski, Martin S. Rice Oct 2025

Evaluating The Self-Efficacy Of Novice Educators In Nursing And Allied Health Care Programs As It Pertains To Faculty Development, Amanda Doneski, Martin S. Rice

Internet Journal of Allied Health Sciences and Practice

Purpose: Career choices in nursing and allied health include but are not limited to nursing, radiologic technology, dental hygiene, respiratory therapy, and occupational therapy.1The majority of health care professions require the practitioner to hold certain required credentials. These credentials are obtained upon successful graduation from an accredited curriculum, passing some sort of board exam, and applying for and obtaining a state license to practice in their designated area of expertise.2 Advancement opportunities in management, sales, and education are attainable for many healthcare professionals.3 Individuals who transition from the role of a health care provider to educator …


Impact Of An Educational Workshop On Occupational Therapy Students’ Perceptions Of People With Experiences Of Addiction, Averie E. Robertson, Bianca A. Chapa, Samantha J. Dooley, Jillian K. Paguiligan, Emily K. Simpson Oct 2025

Impact Of An Educational Workshop On Occupational Therapy Students’ Perceptions Of People With Experiences Of Addiction, Averie E. Robertson, Bianca A. Chapa, Samantha J. Dooley, Jillian K. Paguiligan, Emily K. Simpson

Internet Journal of Allied Health Sciences and Practice

Purpose: As a result of stigma, people with experiences of addiction are subjected to discrimination by health professionals and students, including within occupational therapy (OT). Education and exposure can improve care and empathy. The purpose of this study was to determine if a workshop for OT students impacted their attitudes towards people with experiences of addiction. Methods: Electronic surveys were conducted with OT students before (n=58) and after (n=22) the workshop and included questions on knowledge and attitudes. Data was analyzed using descriptive statistics and paired t-tests. Two focus groups (n=5) were also conducted. Results: There were significant changes in …


A Cross-Sectional Study On Teenage Pregnancy And Its Associated Factors In A District Of Eastern India, Ashifa Sultana, Jayita Pal, Purnashree Mandal, Manoj Ghosh Oct 2025

A Cross-Sectional Study On Teenage Pregnancy And Its Associated Factors In A District Of Eastern India, Ashifa Sultana, Jayita Pal, Purnashree Mandal, Manoj Ghosh

Internet Journal of Allied Health Sciences and Practice

Introduction: Teenage pregnancy is a global public health concern with wide-ranging consequences for adolescent mothers, their families, and society at large. By investigating sociodemographic factors, contraceptive knowledge, and family dynamics, this study aimed to gain a comprehensive understanding of the factors contributing to teenage pregnancy in Nadia district, West Bengal, India.

Materials & method: A cross-sectional study was conducted among 232 pregnant women of Chakdaha block. The study participants were selected by simple random sampling from the line list available at the sub-centres. The Chakdaha block of Nadia district was chosen by multistage sampling. All the pregnant women thus included …


An Academia-Community Partnership Aiming To Benefit The Well-Being Of Shelter Cats And Promote The Learning Outcomes Of College Students, Shlomit Flaisher-Grinberg Oct 2025

An Academia-Community Partnership Aiming To Benefit The Well-Being Of Shelter Cats And Promote The Learning Outcomes Of College Students, Shlomit Flaisher-Grinberg

People and Animals: The International Journal of Research and Practice

More than three million cats enter U.S. animal care and control facilities annually. Although many are adopted, others spend a prolonged amount of time at the animal shelter while facing a variety of stressors. The current project explored the possibility of creating an academia–community partnership aiming to establish a college-based foster program that will allow undergraduate students to socialize and train shelter cats as a part of an academic course. It was hypothesized that the program will positively impact the well-being of shelter cats, improve their adoption outcomes, and support students’ learning outcomes. Students enrolled in the Learning course at …


(((Qpie))) Prior Art Disclosure 3 Of 9: Quantum Perspective Is Everything, Teddy Burroughs Oct 2025

(((Qpie))) Prior Art Disclosure 3 Of 9: Quantum Perspective Is Everything, Teddy Burroughs

Defensive Publications Series

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The Grand Unified Theory (QPIE)

Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters

(((QPIE)))Prior Art Disclosure 3 of 9: Quantum Perspective Is Everything

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Has “Better Fafsa” Been Better Or Worse? A Study Of Student And Stakeholders’ Experience With The 2024-25 Fafsa, Jonathan S. Lewis, Alyssa Stefanese Yates Oct 2025

Has “Better Fafsa” Been Better Or Worse? A Study Of Student And Stakeholders’ Experience With The 2024-25 Fafsa, Jonathan S. Lewis, Alyssa Stefanese Yates

Journal of Student Financial Aid

The 2024-25 or “Better” FAFSA was intended to be simpler, addressing long standing issues with the federal financial aid application process, and expand financial aid eligibility to more low-income students and their families. However, its problematic implementation had negative implications for college access, affordability, and enrollment. This study reviews findings from a mixed methods case study of 274 students, parents, high school counselors, and financial aid administrators’ experiences navigating the 24-25 FAFSA. Interpreting participant responses through an administrative burden lens, the study found some intentional changes in the 24-25 FAFSA, such as the Direct Data Exchange and user-centered design elements, …


The Nature Of Inspiration In The Health Writings Of Ellen White, Don Mcmahon Oct 2025

The Nature Of Inspiration In The Health Writings Of Ellen White, Don Mcmahon

Ellen White and Current Issues Symposium

No abstract provided.


Improving Relationship-Based Feeding Of Infants And Young Children With Disabilities: Developing A Guideline For Practice, Patricia Henton, Tsu-Hsin Howe Oct 2025

Improving Relationship-Based Feeding Of Infants And Young Children With Disabilities: Developing A Guideline For Practice, Patricia Henton, Tsu-Hsin Howe

The Open Journal of Occupational Therapy

Feeding is a significant co-occupation of young children and their caregivers, unfolding in a social context. While addressing feeding challenges comprehensively because multiple contributing factors, the social-emotional dimension is often overlooked. This paper proposes a relationship-based feeding guideline to help occupational therapists incorporate this critical component. Centered on the child-caregiver dyad, the guideline prioritizes supporting the developmental, social-emotional, and environmental needs of the child. The guideline employs a biopsycho-ecological framework and family-centered approach, emphasizing caregiver training for promoting positive interaction. Actively involving caregivers and employing caregiver-child coaching facilitates the learning of developmentally appropriate feeding strategies that are then applied at …


Integrative Neural Networks Frame Of Reference: Application In Practice, Glenda E. Hux, Sarah Schoen Oct 2025

Integrative Neural Networks Frame Of Reference: Application In Practice, Glenda E. Hux, Sarah Schoen

The Open Journal of Occupational Therapy

The INN Frame of Reference supports occupational engagement in caregivers of children and youth with complex health care needs. It guides the occupational therapist from evaluation to intervention providing a structure to identify challenges in occupational engagement. It describes the process of selecting evidence-based interventions to mitigate the impact of prolonged stress on the “whole” parent across contexts. The theoretical base outlines the mechanisms of action that support physiological, affective/cognitive, and social/spiritual health, and the concepts related to intervention. The completion of an occupational profile and the INN Evaluation Checklist sets the stage for data-driven decision making. The occupational therapist …


Integrative Neural Networks: A Novel Frame Of Reference To Support Occupational Engagement In Caregivers, Glenda E. Hux, Sarah A. Schoen Oct 2025

Integrative Neural Networks: A Novel Frame Of Reference To Support Occupational Engagement In Caregivers, Glenda E. Hux, Sarah A. Schoen

The Open Journal of Occupational Therapy

The Integrative Neural Networks (INN) frame of reference is an integrated approach to support occupational engagement in parents and primary caregivers of children and youth with complex health care needs (CYSHCN) guided by principles of family-centered care. Given the potential influence of prolonged, cumulative, and or repeated stress on physiological, affective/cognitive, and social/spiritual health, it is imperative that occupational therapists partner with parents and primary caregivers to positively impact occupational engagement across contexts. Further, this frame of reference provides an avenue to identify potential health and occupational disparities historically under-recognized as independent from the needs of the child. Based on …


Limb Regeneration In Damselflies Based On Developmental Stage, Haven O. Clements Oct 2025

Limb Regeneration In Damselflies Based On Developmental Stage, Haven O. Clements

Inquiry: The University of Arkansas Undergraduate Research Journal

Injury is common in wild animals, yet some species possess an adaptive advantage: regeneration. Enallagma vesperum, a species of damselfly, exhibits this regenerative ability, though its persistence and effectiveness across developmental stages remain poorly understood. While previous studies indicate that regeneration ceases following adult emergence, it is unclear whether this ability also diminishes prior to the final larval molt. This study investigated the effectiveness of limb regeneration in E. vesperum across early and late larval instars. I hypothesized that earlier instars would exhibit greater regenerative success due to fewer competing energetic demands compared to later instars, which may prioritize …


Research Progress In Light Treatment For Postharvest Preservation Of Fruits And Vegetables, Lili Zheng, Yue Lin Oct 2025

Research Progress In Light Treatment For Postharvest Preservation Of Fruits And Vegetables, Lili Zheng, Yue Lin

Journal of Food Science and Biotechnology

Postharvest fruits and vegetables often face issues of senescence and diseases,which lead to a decline in quality.Although conventional preservation techniques are widely applied,some of them have certain health risks.Light treatment,as an emerging non-thermal and non-toxic preservation technology,has attracted attention in the food industry.On the basis of the impacts of light on plant physiology and microbial growth,light treatment helps to maintain the freshness and market value of fruits and vegetables.The light sources for light treatment mainly include light-emitting diodes (LED ),ultraviolet (UV),fluorescent lamps (FL),and pulsed light (PL).This review explores the application mechanisms and effects of light treatment in the preservation of …


The Parthenon, October 15, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Caden Adkins, Scott Price, Lilli Ross, Wade Sullivan Oct 2025

The Parthenon, October 15, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Caden Adkins, Scott Price, Lilli Ross, Wade Sullivan

The Parthenon

No abstract provided.


Like To Talk To A Supervisor: The Relationship Between Perceived Supervisor Support And Turnover Intention In Remote Call Centers In The United States, Cory Barnhart Oct 2025

Like To Talk To A Supervisor: The Relationship Between Perceived Supervisor Support And Turnover Intention In Remote Call Centers In The United States, Cory Barnhart

JWU Dissertations & Theses

The goal of this study was to explore turnover intention and perceived supervisor support among remote customer service employees in the United States as no known published research exists. Turnover intention is the feeling an individual experiences up to the moment they decide to leave an organization (Mobley et al., 1977). According to Haynie et al., (2022), perceived supervisor support is an aspect of perceived organizational support that focuses on the employee’s perception of their direct leader. Remote customer service employees experience isolation and a unique stress of emotional dissonance that can be offset by training and other supervisor interventions …


Ultrasonic-Microwave Assisted Extraction Of Flavonoids From Citri Reticulatae Pericarpium And High-Purity Purification Of Hesperidin, Weiben Ge, Yiheng Li, Hongxin Wang Oct 2025

Ultrasonic-Microwave Assisted Extraction Of Flavonoids From Citri Reticulatae Pericarpium And High-Purity Purification Of Hesperidin, Weiben Ge, Yiheng Li, Hongxin Wang

Journal of Food Science and Biotechnology

[Objective ] To explore the application prospects of Citri Reticulatae Pericarpium in the food industry and efficiently extract the active component hesperidin,while developing an effective purification process to enhance the purity and functional value of the active ingredients.[Method ] Ultrasonic-microwave assisted extraction (U-MAE ) was employed to extract the hesperidin from Citri Reticulatae Pericarpium,followed by a three-stage purification system guided by dissolution characteristics involving alcohol removal by concentration,gradient ethanol washing,and pH adjustment to purify hesperidin.Single factor experiments and response surface methodology were used to optimize the extraction parameters.The antioxidant activity and α-glucosidase inhibitory activity of the final product were also …


Establishment Of A Hplc Method For Simultaneous Determination Of 11 Phenolic Acids In Germinated Black Wheat, Qian Li, Xiaodong Li, Ziyi Yang, Yueyao Zhang, Rui Liu, Zhanglong Yu, Yuanlin Sun Oct 2025

Establishment Of A Hplc Method For Simultaneous Determination Of 11 Phenolic Acids In Germinated Black Wheat, Qian Li, Xiaodong Li, Ziyi Yang, Yueyao Zhang, Rui Liu, Zhanglong Yu, Yuanlin Sun

Journal of Food Science and Biotechnology

[Objective ] In order to study the effects of germination on the mass fractions of phenolic acids in black wheat,a method was established for simultaneous determination of 11 phenolic acids (gallic acid,protocatechuic acid,4-hydroxybenzoic acid,chlorogenic acid,vanillic acid,caffeic acid,syringic acid,p-coumaric acid,ferulic acid,sinapic acid,and salicylic acid ) in germinated black wheat based on high performance liquid chromatography (HPLC ).[Method ] The mobile phase composed of methanol (containing acetic acid at a volume fraction of 1%) and water (containing acetic acid at a volume fraction of 1%) was used for gradient elution at a flow rate of 1 mL/min,a detection wavelength of 280 nm,and …


Dual-Nozzle 3d Printing And Drying Characteristics Of A Hawthorn Snack Based On Dual-Material Combination Gel, Aimiao Wang, Bo Wang, Yuchuan Wang, Jiguang Liu Oct 2025

Dual-Nozzle 3d Printing And Drying Characteristics Of A Hawthorn Snack Based On Dual-Material Combination Gel, Aimiao Wang, Bo Wang, Yuchuan Wang, Jiguang Liu

Journal of Food Science and Biotechnology

[Objective ] This study aims at solving the problems such as long drying time,single product shape,and poor 3D printing capacity (easy blockage and weak bracing ability ) in conventional processing of hawthorn snack products.[Method ] The low-sugar hawthorn jam and high-sugar banana jam were used as gel components.The 3D printing was carried out with the optimization of dual-material combination gel formula and the optimization of dual-nozzle 3D printing process.Furthermore,the drying characteristics of 3D printing were analyzed and compared with those of conventional dried hawthorn products.[Result ] The combination of hawthorn jam with the sugar mass fraction of 26% and banana …


Respiratory Characteristics Of Late-Maturing Sweet Cherry Cultivars And Their Influence By Temperature And Packaging Methods, Huanhuan Zhi, Yu Dong Oct 2025

Respiratory Characteristics Of Late-Maturing Sweet Cherry Cultivars And Their Influence By Temperature And Packaging Methods, Huanhuan Zhi, Yu Dong

Journal of Food Science and Biotechnology

[Objective ] This study aims to develop suitable packaging strategies for sweet cherry varieties with different respiratory characteristics.[Method ] The sweet cherry cultivars ‘Lapins’ and ‘Regina’ were put in closed systems with different O 2 volume fractions at 0,5,and 10 ℃.The changes in O 2 consumption rate,CO 2 consumption rate,and respiratory quotient were monitored.Additionally,the changes of gas components,quality,and physiological disorders were assessed for the two cultivars treated with polyethylene (PE) and modified atmosphere packaging (MAP ) after 4 weeks of storage at 0,5,and 10 ℃.[Result ] ‘Lapins’ had lower O 2 consumption rate and CO 2 consumption rate than ‘Regina’ …


Effects Of Ginger Protease On Beef Quality And Protein Degradation, Xinghua Chen, Shuhong Liu, Huaisheng Zheng, Zhaobin Huang, Ping Hu Oct 2025

Effects Of Ginger Protease On Beef Quality And Protein Degradation, Xinghua Chen, Shuhong Liu, Huaisheng Zheng, Zhaobin Huang, Ping Hu

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the effects of ginger protease on beef tenderness.[Method ] Ginger protease was extracted from mature ginger via ammonium sulfate precipitation.The fundamental properties of the ginger protease,including enzyme activity,protein mass fraction,optimal temperature and pH,and relative molecular mass,were evaluated.Furthermore,the effects of ginger protease on the physicochemical properties,sensory quality,microstructure,and protein degradation characteristics of beef were examined.[Result ] Ginger protease was mainly composed of two proteins with relative molecular masses of 15 293 and 34 191,with a total protein mass fraction of (574.60±0.25) mg/g,an enzyme activity of (31 787±307) U/g,an optimum temperature of 60 ℃,and an optimum …


Effects Of Critical Environmental Factors On The Antimicrobial Activity Of Ε-Poly- L-Lysine, Zhenjie Liu, Peihao Huang, Shu Chen, Shun Rong, Feiting Peng, Ling Chen, Weipeng Guo Oct 2025

Effects Of Critical Environmental Factors On The Antimicrobial Activity Of Ε-Poly- L-Lysine, Zhenjie Liu, Peihao Huang, Shu Chen, Shun Rong, Feiting Peng, Ling Chen, Weipeng Guo

Journal of Food Science and Biotechnology

[Objective ] This study explored the effects of critical environmental factors [water activity (aw),pH,and temperature ] on the antimicrobial activity of ε-poly- L-lysine (ε-PL),aiming to provide a basis for the application of ε-PL.[Method ] With Staphylococcus aureus as an indicator strain,the micro-broth dilution and agar dilution methods as well as antimicrobial growth kinetics were utilized to determine the antimicrobial activity of ε-PL.The protein leakage assay was employed to evaluate the bacterial membrane disruption activity of ε-PL.Live/Dead fluorescence staining was performed to observe the bacterial membrane permeability.[Result ] The minimum inhibitory mass concentration (MIC ) of ε-PL against Staphylococcus aureus was …


Probiotic Properties Of Three Strains Of Lactobacillus And Their Application In Corn Husk Fermentation, Bo Zhai, Quanxian Shu, Xiaoyan Yang, Yin Mao, Yu Deng, Yunying Zhao Oct 2025

Probiotic Properties Of Three Strains Of Lactobacillus And Their Application In Corn Husk Fermentation, Bo Zhai, Quanxian Shu, Xiaoyan Yang, Yin Mao, Yu Deng, Yunying Zhao

Journal of Food Science and Biotechnology

[Objective ] This study aims to improve the utilization of maize resources and address the shortage of feed resources.[Method ] The intestinal colonization capacity,tolerance,and antibacterial properties of three Lactobacillus strains,Lactobacillus paracasei ZB- 1 (ZB-1),L.paracasei DY- 2 (DY-2),and L.rhamnosus DY- 4 (DY-4) were evaluated.The most suitable strain for fermenting cornhusks was identified,and its fermentation process was optimized.[Result ] ZB-1 exhibited higher intestinal colonization ability and antibacterial properties than DY- 2 and DY- 4.The antibacterial mechanism of ZB- 1 was likely driven by the action of organic acids in an acidic environment and certain protein-based antimicrobial substances.The fermentation conditions for ZB- 1 …


Diversity Of Fungi On The Surfaces Of Grapes And Raisins In Turpan , Xinjiang, Lei Sun, Laifang Qi, Qiuyan Liang, Jinxuan Han, Tianli Fan, Yuhua Ma Oct 2025

Diversity Of Fungi On The Surfaces Of Grapes And Raisins In Turpan , Xinjiang, Lei Sun, Laifang Qi, Qiuyan Liang, Jinxuan Han, Tianli Fan, Yuhua Ma

Journal of Food Science and Biotechnology

[Objective ] This study aims to understand the potential harmful fungi that may affect the quality of raisins during the drying process of grapes from Turpan,Xinjiang and to explore the relationships between varieties and the fungal community structure and diversity on the surfaces of grapes and raisins.[Method ] Four popular grape varieties (‘Thompson Seedles s’,‘Boert e’,‘Xiangfe i’,and ‘Seedless Blac k’) in a grapery in Turpan were selected as research objects.The fungal diversity on the surfaces of grapes and raisins was analyzed via high-throughput sequencing.[Result ] The dominant fungal phyla on the surfaces of grapes and raisins were Ascomycota and Basidiomycota.The …


Regulatory Effects Of Hesperetin And Eriocitrin On Gut Microbiota In An In Vitro Simulation Model, Zeren Cheng, Xia Meng, Kejing Tang, Ling Shen, Qing Gu, Ping Li Oct 2025

Regulatory Effects Of Hesperetin And Eriocitrin On Gut Microbiota In An In Vitro Simulation Model, Zeren Cheng, Xia Meng, Kejing Tang, Ling Shen, Qing Gu, Ping Li

Journal of Food Science and Biotechnology

[Objective ] This study aims to compare the effects of hesperetin and eriocitrin on the gut microbiota in different enterotypes.[Method ] An in vitro gut fermentation model was established,which was combined with 16S rRNA high-throughput sequencing and gas chromatography-mass spectrometry (GC-MS ) technique to evaluate the regulatory effects of the two flavonoids on the gut microbiota in different enterotypes.[Result ] After fermentation,both flavonoids significantly reduced the Firmicutes-to-Bacteroidota ratio (F/B ratio ) in terms of relative abundance at the phylum level in enterotype Bacteroides and enterotype Prevotella.At the genus level,pro-inflammatory bacteria including Paeniclostridium and Sutterella showed decreased relative abundance in treatment …


Daily Eastern News: October 15, 2025, Eastern Illinois University Oct 2025

Daily Eastern News: October 15, 2025, Eastern Illinois University

Daily Eastern News: 2025-2026

No abstract provided.


Large Language Models As Information Providers For Appropriate Antimicrobial Use: Computational Text Analysis And Expert-Rated Comparison Of Chatgpt, Claude And Gemini, Marcello Di Pumpo, Maria Rosaria Gualano, Danilo Buonsenso, Francesca Raffaelli, Daniele Donà, Vittorio Maio, Patrizia Laurenti, Walter Ricciardi, Leonardo Villani Oct 2025

Large Language Models As Information Providers For Appropriate Antimicrobial Use: Computational Text Analysis And Expert-Rated Comparison Of Chatgpt, Claude And Gemini, Marcello Di Pumpo, Maria Rosaria Gualano, Danilo Buonsenso, Francesca Raffaelli, Daniele Donà, Vittorio Maio, Patrizia Laurenti, Walter Ricciardi, Leonardo Villani

College of Population Health Faculty Papers

OBJECTIVES: Antimicrobial resistance is a critical public health threat. Large language models (LLMs) show great capability for providing health information. This study evaluates the effectiveness of LLMs in providing information on antibiotic use and infection management.

METHODS: Using a mixed-method approach, responses to healthcare expert-designed scenarios from ChatGPT 3.5, ChatGPT 4.0, Claude 2.0 and Gemini 1.0, in both Italian and English, were analysed. Computational text analysis assessed readability, lexical diversity and sentiment, while content quality was assessed by three experts via DISCERN tool.

RESULTS: 16 scenarios were developed. A total of 101 outputs and 5454 Likert-scale (1-5) scores were obtained …


Resilience And Vulnerabilities Of Tumor Cells Under Purine Shortage Stress, Jianpeng Yu, Chen Jin, Cheng Su, David Moon, Michael A Sun, Hong Zhang, Xue Jiang, Fan Zhang, Nomi Tserentsoodol, Michelle L Bowie, Christopher J Pirozzi, Daniel J George, Robert Wild, Xia Gao, David M Ashley, Yiping He, Jiaoti Huang Oct 2025

Resilience And Vulnerabilities Of Tumor Cells Under Purine Shortage Stress, Jianpeng Yu, Chen Jin, Cheng Su, David Moon, Michael A Sun, Hong Zhang, Xue Jiang, Fan Zhang, Nomi Tserentsoodol, Michelle L Bowie, Christopher J Pirozzi, Daniel J George, Robert Wild, Xia Gao, David M Ashley, Yiping He, Jiaoti Huang

Faculty, Staff and Students Publications

Purpose: Purine metabolism is a promising therapeutic target in cancer; however, how cancer cells respond to purine shortage, particularly their adaptation and vulnerabilities, remains unclear.

Experimental design: Using the recently developed purine shortage-inducing prodrug DRP-104 and genetic approaches, we investigated the responses in prostate, lung, and glioma cancer models.

Results: We demonstrate that when de novo purine biosynthesis is compromised, cancer cells employ microtubules to assemble purinosomes, multiprotein complexes of de novo purine biosynthesis enzymes that enhance purine biosynthesis efficiency. Although this process enables tumor cells to adapt to purine shortage stress, it also renders them more susceptible to the …


Estrogen-Related Receptor Alpha Promotes Skeletal Muscle Regeneration And Mitigates Muscular Dystrophy, Thi Thu Hao Nguyen, Ya Xiang Huang, Svitlana Poliakova, Citu Citu, Eira Mann, Danesh H Sopariwala, Zhongming Zhao, Ashok Kumar, Vihang A Narkar Oct 2025

Estrogen-Related Receptor Alpha Promotes Skeletal Muscle Regeneration And Mitigates Muscular Dystrophy, Thi Thu Hao Nguyen, Ya Xiang Huang, Svitlana Poliakova, Citu Citu, Eira Mann, Danesh H Sopariwala, Zhongming Zhao, Ashok Kumar, Vihang A Narkar

The Brown Foundation: Institute of Molecular Medicine

Skeletal muscle regeneration in chronic muscle diseases such as Duchenne Muscular Dystrophy (DMD) has remained clinically unsurmountable. Estrogen‐related receptor alpha (ERRα) plays a critical role in adult skeletal muscle metabolism and exercise fitness. Whether ERRα activation can drive muscle regeneration and mitigate dystrophy in DMD is not known. We have investigated ERRα signaling in pre‐clinical models of acute muscle injury and DMD. ERRα is induced in differentiating C2C12 myoblast and regenerating muscle. ERRα silencing suppressed proliferation and differentiation in C2C12 myoblasts. RNA sequencing revealed that angiogenic factor and proliferation genes were downregulated by ERRα knockdown in proliferating cells, whereas oxidative …