Digital Commons Network^™

Use Of The Selective Cytopheretic Device With Continuous Renal Replacement Therapy In Children: A Comparison Of Contemporary Cohorts, Natalja L Stanski, Jangdong Seo, Todd Jenkins, Kelli A Krallman, Shina Menon, H David Humes, David J Askenazi, Rajit K Basu, Ayse Akcan-Arikan, Stuart L Goldstein, Katja M Gist

Faculty, Staff and Students Publications

Introduction: The selective cytopheretic device (SCD) is a cell-directed extracorporeal therapy approved for use in children with acute kidney injury (AKI) receiving continuous renal replacement therapy (CRRT) with sepsis/sepsis-like conditions. We compared outcomes for children treated with SCD to a contemporary cohort of children treated with CRRT alone.

Methods: Secondary analysis and comparison of patients ≤22 years old and ≥10 kg from a multicenter registry of patients receiving CRRT for AKI and/or fluid overload (WE-ROCK; 2015-2021) to patients from two multicenter, prospective, interventional studies of children with AKI and multiple organ dysfunction (MODS) receiving SCD (SCD-PED-01/SCD-PED-02; 2016-2022).

Results: Eighteen patients …

Xpert Mtb/Rif Ultra Assay For Tuberculosis Disease And Rifampicin Resistance In Children, Alexander W Kay, Maia Madison, Katie Scandrett, Tara Ness, Pauline Amuge, Leeberk Raja Inbaraj, Mukesh Kumar Sathya Narayanan, Lucia González Fernández, Michael Eisenhut, Nazir Ismail, Alexei Korobitsyn, Sabine E Verkuijl, Annemieke Brands, Kerri Viney, Tiziana Masini, Anna M Mandalakas, Karen R Steingart, Yemisi Takwoingi

Faculty, Staff and Students Publications

Background: In 2023, an estimated 1.3 million children (aged 0-14 years) became ill with tuberculosis, and 166,000 children (aged 0-15 years) died from the disease. Xpert MTB/RIF Ultra (Xpert Ultra) is a molecular World Health Organization (WHO)-recommended rapid diagnostic test that detects Mycobacterium tuberculosis complex and rifampicin resistance. This is an update of a Cochrane review first published in 2020 and last updated in 2022. Parts of the current update informed the 2024 WHO updated guidance for the diagnosis of tuberculosis.

Objectives: To assess the diagnostic accuracy of Xpert Ultra for detecting pulmonary tuberculosis, tuberculous meningitis, lymph node tuberculosis, and …

Understanding Short Stature In Pediatrics: Key Insight, Micahel Smith, Pratibha Rana

Pediatrics in Practice: A CME Podcast

In this episode of Pediatrics in Practice, Dr. Mike and Dr. Pratibha Rana from Children's Mercy unravel the complexities of caring for patients with short stature. They discuss common causes, evaluation techniques, and treatment approaches. Ideal for pediatricians, this episode highlights clinical decision-making tools for better patient outcomes.

Click here to stream the podcast episode.

The Current - Volume 36 Issue 4, Nova Southeastern University

Student Newspapers

No abstract provided.

Using An Old Assay In New Ways: Differential Scanning Calorimetry Characterization, Quantification, And Interaction Analysis Of Whey Proteins, Charity Conlin Jennings

Theses and Dissertations

Whey proteins including β-Lactoglobulin, α-Lactalbumin, Immunoglobulin-G, Serum Albumin, Lactoferrin, and Lactoperoxidase each have unique biological properties spanning anti-bacterial, anti-fungal, and anti-viral activities as well as deliver essential nutrients to the human body. In the past decade, there has been a large focus on extracting these individual proteins for their use in foods and supplements. In order to best extract these proteins and prepare them properly in foods and supplements, an understanding of how they behave and denature in different environments is necessary. However, there is insufficient knowledge of their thermodynamic properties and potential interactions in varying conditions. Additionally, there are …

Mold Exposure And Cognitive Health During Menopausal Transitions: A Quantitative Analysis Using Secondary Data, Holly Jeannette Burns

Walden Dissertations and Doctoral Studies

Mold exposure and menopausal transition have been independently linked to cognitive decline, yet their interaction among socioeconomically disadvantaged populations has not been well examined. This quantitative study is an exploration of how menopausal transition influences the relationship between mold exposure and cognitive health outcomes among women aged 40 to 60 living in low-income housing in the United States. Bronfenbrenner’s ecological systems theory was used to guide the cross-sectional design using secondary data from the 2005–2006 National Health and Nutrition Examination Survey (NHANES; N = 149). Weighted logistic regression and Hayes’ PROCESS (Models 2 and 4) were used to test associations …

Resources And Strategies Needed To Address The Problem Of Child Labor In Erbil, Kurdistan Region Of Iraq, Evan Faiq

Walden Dissertations and Doctoral Studies

Child labor is an international practice that has been on the rise in some parts of the world including Erbil, the Kurdistan region of Iraq. The purpose of this qualitative study was to explore the different resources needed but not available for the victims, how child labor has impacted the community, and how the criminal justice system can better approach the child labor issue and reduce it in Erbil, Kurdistan region of Iraq. Social conflict theory was used to guide the study. Data were collected from 15 interviews with individuals from different areas of the criminal justice department, local organizations …

Sociocultural Factors Influencing Excess Gestational Weight Gain In Pregnant Puerto Rican Women, Sonia O. Roselló Aponte

Walden Dissertations and Doctoral Studies

More than 50% of women experience excessive weight gain during pregnancy or are overweight at the start of pregnancy, increasing their risk of short and long-term maternal and fetal complications. The literature highlights the relationship between sociocultural factors and excessive gestational weight gain (EGWG) and the need to explore these factors in ethnic subgroups. The purpose of this descriptive qualitative study, guided by Nola Pender’s health promotion model, was to explore the sociocultural factors that influence EGWG for pregnant women living in Puerto Rico. Semi-structured interviews were conducted with seven participants recruited from public and private prenatal clinics in Puerto …

A Risk-Based Assessment And Intervention Planning Tool For The Prevention Of Hospital-Acquired Pressure Injuries, Kathleen A. Widmer

Creating Healthy Work Environments (CHWE)

Hospital-acquired pressure injury prevention is a priority for nursing quality and has implications for patient outcomes and healthcare costs. This project implemented a tool guiding risk screening and care planning among bedside nurses. While results were non-significant, positive trends were identified, and key barriers for prevention identified.

Detailed abstract attached.

October 23, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

The Financial Inclusion Gender Gap: A Case Study Of Households In Indonesia, Meigendaris Surtiabadi Putri, Djoni Hartono

Jurnal Ekonomi dan Studi Pembangunan

The financial inclusion gender gap is an important issue that has become a global concern, as financial inclusion can enhance women's empowerment in various aspects. Using the Fairlie Decomposition method, this study aims to describe whether there is financial inclusion gender gap in Indonesia and analyze what factors contribute significantly to the gap. This study represents one of the earliest analyses of the household financial inclusion gender gap, using the decomposition method, which is considered the most suitable for quantifying the contribution of the factors to the gap. The findings reveal that female-headed households have less access to financial inclusion. …

Basic Dimensions And Community Welfare In The Boti Tribe In The Island Of Timora, Kamilaus Konstanse Oki

Jurnal Ekonomi dan Studi Pembangunan

The Boti tribe is the most unique indigenous traditional tribe on the island of Timor and even in the world. In the economic field, the Boti tribe fulfills economic needs independently through farming and refuses all kinds of government assistance, refuses technological production or modernization and formal education for the younger generation. However, the people of the Boti tribe feel very prosperous with their economic and socio-cultural life. The analytical tool used in this research is SmartPLS. The results show that the basic dimensions formed by the dimensions of satisfaction, meaning in life and security needs determine the very prosperous …

2025 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Jaime Pedigo, Jennifer Smith, Patty Watson, Heather Wohltman, Amanda Wolf

Programs

Each year, Eastern Illinois University proudly recognizes the outstanding achievements of our faculty in research, creativity, and engagement. This collection of accomplishments reflects the dedication of an engaged faculty committed to excellence and the continual pursuit of knowledge. Many of these successes were made possible through meaningful collaboration with our students, who contribute as co-authors, research assistants, and partners in bringing ideas to life. Some of these professional milestones represent years of effort, demonstrating remarkable persistence and determination. We offer our heartfelt congratulations on this wide range of achievements, which bring distinction to our departments, colleges, and the University as …

The Lumberjack, October 22, 2025

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Increasing Opportunities For Community Input In Harm Reduction Program Development Using Iterative Engagement., Nicole M. Wagner, Jordan A. Carlson, Meagan Bean, Amy Wineland, Joshua Blum, Scott A. Cardona, Sheila Covarrubias, Allison Kempe, Abby C. King, Amy G. Huebschmann

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Incorporating people who use substances into a community-engaged research process can support the implementation and evaluation of evidence-based harm reduction programs. Attending to their voice ensures those who need these programs will use them. Yet, ongoing co-learning with people who use substances, often the ideal for community engaged research, poses a challenge for recruitment, ongoing participation, and obtaining diverse perspectives. We need novel strategies to support flexibility among populations experiencing legal and social instability so that community engaged work includes more diverse perspectives. In this paper, we describe a novel community engagement approach called Effective Adaptable and Sustainable in …

Nutritional Management Of The Complex Fontan Physiology Patient In The Pre-Transplant Phase, Mona Kasik, Jill Rockwell

2025

No abstract provided.

Rest For Self-Care: Improving Student Nurses’ Health, Karen Higgins, Janice E. Hawkins, Ingrid Mahoney, Jamela M. Martin, Beth Tremblay, Lynn L. Wiles

Creating Healthy Work Environments (CHWE)

The Essentials for nursing education prioritize improving students’ health and resilience. In this presentation, we describe how nursing students used the REST mnemonic to create self-care plans. At the end of the semester, students reported increased engagement in self-care activities and a new awareness of the need for self-care.

Detailed abstract attached.

Defining Endotypes Of Bronchopulmonary Dysplasia In Preterm Infants To Improve Precision-Based Therapies., Megha Sharma, Gangaram Akangire, Noah H. Hillman, Winston M. Manimtim, Mark Ivan Attard, Venkatesh Sampath

Manuscripts, Articles, Book Chapters and Other Papers

Bronchopulmonary dysplasia (BPD) remains a debilitating disease in premature infants. The chronic pathogenesis of BPD with complex prenatal and postnatal programming challenges attempts at precisely defining or treating disease. While existing BPD definitions categorize disease severity, a lack of consideration of disease heterogeneity and endotypes has contributed to the failure of clinical trials to improve BPD outcomes. Recent studies have used advanced lung imaging techniques, echocardiography, and lung function tests to identify airway, parenchymal, and vascular BPD endotypes. These endotypes carry different prognoses and require endotype-specific treatment strategies to optimize infant outcomes. In this Review, we focus on the pathogenic …

Spectrum, Volume 55, Issue 6, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Ongoing Government Shutdown Reaches Week Four -- West Campus Welcomes “The Evans Family Atrium” -- Step by Step: The Walk to End Alzheimer’s -- Navigating AI in the Classroom -- Is Sports Betting Impacting College Students? -- Pioneers’ Basketball Ready for Season Return

Rtx-303, An Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates Parp Inhibitors In Brca Mutant Tumors, Gurushankar Chandramouly, William Fried, John Gordon, Douglas Ralph, Channita Keuk, Sangeeta Kumari, Mercy Ramanjulu, William Auerbacher, Leonid Minakhin, Taylor Tredinnick, Bernadette Tiberi, George Morton, Robert Betsch, Kathy Q. Cai, Umeshkumar M Vekariya, Mrityunjay Tyagi, Tomasz Skorski, Sergey Karakashev, Neil Johnson, Wayne E. Childers, Xiaojiang S. Chen, Richard T. Pomerantz

Department of Biochemistry and Molecular Biology Faculty Papers

DNA polymerase θ (Polθ) is a polymerase-helicase fusion protein that is synthetically lethal with homologous recombination (HR) factors, such as BRCA1/2, and confers resistance to PARP inhibitors (PARPi) and other genotoxic cancer therapies. Previously developed Polθ polymerase (Polθ-pol) inhibitors (Polθi) exhibited limited pharmacological activity and metabolic stability, warranting the development of a Polθi with improved drug-like properties. Here, we developed RTx-303, a selective allosteric small-molecule Polθ-pol inhibitor that exhibits 5.1 nM IC50, 88% oral bioavailability, and a prolonged half-life along with its equipotent metabolite. X-ray crystallography highlights the development of a solvent-exposed side-chain that is essential for the optimal drug-like …

The Genome Sequence Of The Hemlock Woolly Adelgid, Adelges Tsugae Annand 1924, Bryan M.T. Brunet, Dustin T. Dial, Gaelen R. Burke, Carol D. Von Dohlen, Julia Douglas Freitas, Haley Sanderson, Afiya R. Chida, Samantha J. Jones, Fergal J. Martin, Leanne Haggerty, Stephen W. Scherer, Ioannis Ragoussis, Steven J.M. Jones, Robert G. Foottit, Nathan P. Havill

Biology Faculty Publications

The genome of the hemlock woolly adelgid (Adelges tsugae) is presented in 10 chromosomal pseudomolecules along with 132 unplaced scaffolds for a combined length of 216.56 Mb. The genome is highly contiguous with an N50 of 20.54 Mb and its longest scaffold 37.41 Mb in length. The assembly recovered 97.7% of benchmarked universal single-copy Hemiptera orthologs (BUSCO) with an overall completion score of 98.6%. On the basis of chromosomal synteny with other aphid genomes, the hemlock woolly adelgid’s genome is composed of eight autosomes and two sex (X) chromosomes. Annotation of the assembly identified 11,800 coding genes, 1,930 …

Mir147 Promotes Mucosal Integrity And Healing In Intestinal Inflammation, Agnieszka K Czopik, Arash Dabiri, Chia-Hao Tung, Victoria Vaughn, Xiangsheng Huang, Jinlian Wang, Hui Li, Nicolas F Moreno, Natalia V Piwko, Katherine Figarella, Hongfang Liu, Zhongming Zhao, Xiaoyi Yuan, Holger K Eltzschig

Faculty, Staff and Student Publications

The intestinal mucosal epithelium forms a barrier between luminal contents and the body. MicroRNAs (miRNAs) regulate mucosal homeostasis by controlling inflammatory responses and structural integrity. Here, we discovered a protective role for miR147 in intestinal inflammation using a miR147tdTomato reporter mouse. miR147 was enriched in the intestines, with the highest expression in the colonic epithelial cells at the luminal surface, with prominent expression in differentiated enterocytes. Mice with general or intestinal epithelial deletion of miR147 showed increased intestinal inflammation and diminished mucosal healing during colitis. RNA sequencing of miR147-deficient cells showed dysregulated immune signaling, with upregulated proinflammatory cytokine pathways and …

2025-10-22 Message From The President, Morehead State University. Office Of The President.

Staff Congress Records

A message sent by the Office of the President to the campus community on October 22, 2025, regarding upcoming events on campus, homecoming, Board of Regents meeting, academic and personnel calendars, and congratulatory remarks.

Myocardial Protection By Acidic Amino Acids And Natural Dipeptides: Potential For An Underused Resource, N. King

School of Biomedical Sciences

Stopping then restarting the blood flow to the heart can cause ischaemia reperfusion (IR) injury. This can happen during revascularisation following a myocardial infarction and during on pump cardiac surgery using cardioplegic arrest. Despite extensive studies to identify cardioprotective interventions, the myocardium continues to sustain significant injury. Therefore, there is a need to identify agents that can be used during IR. This review focuses on the potential cardioprotective role for acidic amino acids and natural dipeptides using evidence from experimental studies and clinical trials with particular emphasis on their membrane transport. Acidic amino acids are present at high concentration in …

On The Ecological Impact Of Prehistoric Hunter-Gatherers In Europe: Early Holocene (Mesolithic) And Last Interglacial (Neanderthal) Foragers Compared, Anastasia Nikulina, Anhelina Zapolska, Maria Antonia Serge, Didier M. Roche, Florence Mazier, Marco Davoli, Elena A. Pearce, Jens Christian Svenning, Dave Van Wees, Ralph Fyfe, Katharine Macdonald, Wil Roebroeks, Fulco Scherjon

School of Geography, Earth and Environmental Sciences

Recent studies have highlighted evidence of human impact on landscapes dating back to the Late Pleistocene–long before the advent of agriculture. Quantifying the extent of vegetation transformations by hunter-gatherers remains a major research challenge. We address this challenge by comparing climate-based potential natural vegetation cover with pollen-based vegetation reconstructions for the Last Interglacial and the Early Holocene. Differences between these datasets suggest that climate alone cannot fully explain the pollen-based vegetation patterns in Europe during these periods. To explore this issue, we used an upgraded version of the HUMan impact on LANDscapes (HUMLAND) agent-based model (ABM), combined with a genetic …

The Effects Of Combined Fasting And Exercise On Inflammatory Cytokine Concentrations In Healthy Adults: A Randomized Crossover Study, Landon S. Deru, Austin F. Duersch, Spencer C. Cleverly, Hunter D. Chamberlain, Elizabeth Z. Gipson, Parker G. Graves, Cameron G. Jacobsen, Larry A. Tucker, Bruce W. Bailey

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 1252-1268, 2025. https://doi.org/10.70252/APHT9483 The object was to assess the effects of adding exercise to a 36-hour fast on the inflammatory cytokines IL-6, TNF-α, and MCP-1. The study was a randomized crossover design with counterbalanced conditions in community members living near a single academic institution. Participants included twenty healthy adults (11 male). The intervention consisted of two 36-h water-only fasts, one of which was initiated with a bout of treadmill exercise. Venous blood was taken at baseline, 12-h, 24-h, and 36-h of fasting. Area under the curve and timepoint analyses were computed. The area under …

Incidence And Risk Factors Of Metabolic Syndrome In Track And Field Throwing Athletes, Taylor Browning, Samuel Headley, Elizabeth M. Mullin, Margaret T. Jones, Andrew R. Jagim, Jennifer Fields

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 1199-1211, 2025. https://doi.org/10.70252/HOKT7948 Track and field (T&F) throwers are a prominent subgroup of athletes that may be at risk for the development of Metabolic Syndrome (MetSyn) and other cardiometabolic disease conditions. However, limited research exists examining the prevalence of MetSyn in these athletes. Therefore, the purpose of this study was to examine the incidence of MetSyn and associated risk factors in collegiate throwers. Collegiate Division I men (n=17) and women (n=4) T&F throwers participated in a single day of lab assessments, which included anthropometrics, body composition, blood pressure, a venous blood draw, and aerobic …

Upper Extremity Asymmetries In Collegiate Tennis Players Compared To An Athletic Control Of Runners, Elizabeth A. Cafferty, Dale R. Wagner, Brennan J. Thompson

International Journal of Exercise Science

International Journal of Exercise Science 18(3): 1151-1165, 2025. https://doi.org/10.70252/MDRK9289 Previous research on limb asymmetries of athletes participating in dominant-sided sports lacks an athletic control group. This study aimed to determine the magnitude of upper limb asymmetries in dominant-sided athletes (tennis players) compared to nondominant-sided athletes (cross-country runners). Men and women university athletes (10 tennis, 11 cross-country) participated. Dual-energy x-ray absorptiometry (DXA) was used to measure bone mineral content (BMC), bone mineral density (BMD), and lean mass (LM) of the whole body, upper extremities, and forearms. Circumference measurements were taken at mid-biceps and widest part of the forearms. Bony breadth of …

An Example Analysis For A Gender-Inclusive Approach In Sport And Exercise Science Research Using Fitbit Outcomes From The All Of Us Research Program Dataset, James W. Navalta, Dustin W. Davis, Jafra D. Thomas, Whitley J. Stone

International Journal of Exercise Science

International Journal of Exercise Science 18(1): 1133-1141, 2025. https://doi.org/10.70252/HRNQ4501 Prevalence studies with wearable devices are used to understand disparities in health-related physical activity behaviors and whether interventions are efficacious. However, studies have been limited to a binary definition of sex. This example analysis aimed to demonstrate how researchers can investigate differences in data beyond the sex-gender binary. Using a cross-sectional analysis of the All of Us Research Program dataset, participants' self-identified gender was categorized into Cisgender Female (n = 10,401), Additional Options (n = 27), Non-binary (n = 84), Transgender (n = 17), and Cisgender Male …

Ethnic Differences In Health-Related Quality Of Life, Physical Activity, And Health Locus Of Control, Kimberly Feiler

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 1072-1085, 2025. https://doi.org/10.70252/STUM6367 This research aimed to better understand the differences in health-related quality of life (HRQoL: general health, physical functioning), physical activity (PA), and health locus of control (HLOC: internal, external-chance, external-powerful others, God) among various ethnic groups. The study’s sample included 185 individuals, 22 - 81 years of age, who were attending or employed by one of three religiously-affiliated higher education institutions during the 2020-2021 academic year. Participants voluntarily answered questions about their ethnic identity, HRQoL, PA level, and HLOC. To analyze the interaction of HRQoL, PA, and HLOC, a multiple regression …