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Articles 6361 - 6390 of 239936
Full-Text Articles in Entire DC Network
A Gut-Wrenching Battle Within: An Unusual Case Of Pancreatic Desmoid Fibromatosis, Ahmed Qaedi, Ali Hachem, Farrah Ibrahim
A Gut-Wrenching Battle Within: An Unusual Case Of Pancreatic Desmoid Fibromatosis, Ahmed Qaedi, Ali Hachem, Farrah Ibrahim
UAB Huntsville Research Day - All Presentations
2026 clinical vignette poster
Preventing G-J Tube Dislodgement - A Device And Communication Innovation, Sarah Clark
Preventing G-J Tube Dislodgement - A Device And Communication Innovation, Sarah Clark
2026
Abstract
The Problem: G/J tube dislodgement is a frequent complication in pediatric patients.
Leads to:
- Emergency department visits
- Hospital admissions
- Delays in nutrition/medication
Impact on Patients & Families:
- IV placement (traumatic)
- Radiation exposure
- Overnight hospital stays
Impact on Nurses & System:
- Increased workload (admissions, coordination)
- Occupied inpatient beds for stable patients
- Inefficient care processes
Aims/Objectives Aim: Reduce unplanned G/J tube dislodgements and related hospital utilization.
Objectives: Develop a breakaway connector prototype
Implementation and Evaluation:
Setting: Pediatric inpatient & outpatient system
Participants: Nurses (bedside, GI, IR), caregiver, innovation team
Process: Roundtable discussions → identified workflow gaps Communication/workflow audit Developed …
The Gender Binary And Its Effects On Athletes And Society At Large As Described In Newspaper Accounts Of Competitors In The Summer 2024 Olympics, Neo Zheng
Honors College Theses
The purpose of this paper is to look at the impact of gendered language and gender rhetoric on the continued social maintenance of gender, especially as it relates to athletes. This project focuses on the patterns that arise in language of news articles on two female athletes participating in the 2024 Paris Olympics who are accused of being transgender or male, shedding light on how media outlets talk about the topic of gender in athletes specifically, and society itself more generally.
The Syntra Collective, Diana Palomares Bernabé
The Syntra Collective, Diana Palomares Bernabé
Grado en Diseño de Interiores
El proyecto tiene como objetivo explorar la capacidad de la arquitectura para sanar a las personas. El club holístico se organiza en torno a tres áreas de intervención; la sanación física, mental y espiritual. Entendidas como un recorrido continuo y no como espacios aislados, reflejando una filosofía donde el bienestar del individuo es una necesidad cotidiana y no un lujo ocasional. Se propone así un nuevo concepto de lujo, donde lo verdaderamente valioso no es lo material, sino la inversión en uno mismo. Para el diseño se han tenido en cuenta diversos Objetivos de Desarrollo Sostenible, con el fin de …
Triglyceride Glucose Index As A Predictor Of Insulin Resistance In Patients With Hypothyroidism, Nadeen El-Nakeeb, Mohammed A. Helaly, Ahmad S. Hasan, Rania Bahriz
Triglyceride Glucose Index As A Predictor Of Insulin Resistance In Patients With Hypothyroidism, Nadeen El-Nakeeb, Mohammed A. Helaly, Ahmad S. Hasan, Rania Bahriz
Mansoura Medical Journal
Background: Thyroid hormones play a key role in glucose metabolism, and hypothyroidism is frequently associated with impaired insulin secretion, altered glucose disposal, and insulin resistance (IR).
Aim: This study aimed to assess insulin resistance in patients with hypothyroidism using the triglyceride–glucose (TyG) index in comparison with the homeostasis model assessment of insulin resistance (HOMA-IR).
Methods: This case-control study was conducted on 100 participants (50 hypothyroid patients and 50 euthyroid controls), aged 18–60 years. All subjects underwent detailed clinical evaluation, anthropometric measurements, and fasting laboratory investigations including glucose, lipid profile, insulin, TSH, and free T4. Insulin resistance was assessed using TyG …
Impact Of Body Mass Index On Clinical Outcomes In Metastatic Breast Cancer Running Title: Impact Of Bmi On Mbc Outcome, Alaa Abdelrahman Sonbol, Maha Elzaafarany, Ahmed Albehairy, Sherif Refaat
Impact Of Body Mass Index On Clinical Outcomes In Metastatic Breast Cancer Running Title: Impact Of Bmi On Mbc Outcome, Alaa Abdelrahman Sonbol, Maha Elzaafarany, Ahmed Albehairy, Sherif Refaat
Mansoura Medical Journal
Background: Body mass index (BMI) has been suggested as an important patient-related factor influencing treatment outcomes in breast cancer. This study aimed to evaluate the association between BMI categories and clinical outcomes among patients with metastatic breast cancer (MBC).
Patients and Methods: This retrospective study included 400 patients with MBC. Clinical outcomes assessed included response to first-line treatment, treatment-related toxicity, and status at last follow-up and BMI was calculated using the Quetelet index .
Results: Patients were characterized by a high prevalence of obesity and predominantly good performance status. Disease progression following first-line treatment was the most common …
Serum High Sensitivity Cardiac Troponin I Level And Its Relation To Severity Of Psoriasis Vulgaris, Aya Hassan Mohammed El-Shamy, Samia Mohammed Abdel Naby, Mohammed Fawzy El Sayed, Amany Ragab Youssef Ahmed
Serum High Sensitivity Cardiac Troponin I Level And Its Relation To Severity Of Psoriasis Vulgaris, Aya Hassan Mohammed El-Shamy, Samia Mohammed Abdel Naby, Mohammed Fawzy El Sayed, Amany Ragab Youssef Ahmed
Mansoura Medical Journal
Background: Psoriasis is a chronic inflammatory skin disease affecting 2.5% of the worldwide population. Troponin I levels are accompanied by cardiovascular disease (CVD) risk in psoriatic cases. So, this study was conducted to detect serum levels of high-sensitivity cardiac troponin I (HScTnI) in psoriasis vulgaris (PV) cases compared to healthy controls. Methods: This case-control study included 40 cases with PV and 40 healthy subjects as a control group. Disease severity evaluation was conducted by using the psoriasis area severity index (PASI) score to classify the cases into groups according to severity. Measurement of HScTnI levels was conducted. Results: Mean HsCTn …
The Role Of Vitamin D In Management Of Pediatric Chronic Immune Thrombocytopenia, Eman Magdy Yahia, Suzy Abd El Mabood Abd El Hameed, Dalia Tawfeek Hussein, Amany Mamdouh Shoumah
The Role Of Vitamin D In Management Of Pediatric Chronic Immune Thrombocytopenia, Eman Magdy Yahia, Suzy Abd El Mabood Abd El Hameed, Dalia Tawfeek Hussein, Amany Mamdouh Shoumah
Mansoura Medical Journal
In children, immune thrombocytopenia (ITP) remains a serious health concern, which is an autoimmune disorder (AID) characterized by an isolated decrease in platelet count, leading to an increased risk of bleeding.
The use of vitamin D supplementation represents a turning point in many autoimmune diseases, with the potential to deliver high cure rates with fewer side effects than previous therapies. In this review, we explore the incidence of ITP , immunopathogenesis, diagnosis and management in pediatric patients. We will discuss the mechanisms of action of vitamin D , focusing on its role in autoimmune diseases especially ITP
Red Cell Distribution Width As A Prognostic Factor And Its Comparison With Lactate In Patients With Sepsis: An Observational Prospective Cohort Study, Ahmed Taha Gad, Ghada Fathy El-Rahmawy, Naglaa Abd El-Latif El-Negeery, Eiad Ahmed Ramzy
Red Cell Distribution Width As A Prognostic Factor And Its Comparison With Lactate In Patients With Sepsis: An Observational Prospective Cohort Study, Ahmed Taha Gad, Ghada Fathy El-Rahmawy, Naglaa Abd El-Latif El-Negeery, Eiad Ahmed Ramzy
Mansoura Medical Journal
Background: Red blood cell distribution width (RDW) is a straightforward and cost-effective parameter that is utilized in laboratory hematology to differentiate anemias. It is indicative of the grade of heterogeneity in erythrocyte volume. This study purpose examine the correlation among the risk of adverse results in patients with sepsis and RDW, as well as to equivalence the mortality discriminative capacity of RDW and lactate levels.
Methods: This observational prospective cohort study was done on 67 sepstic patients aged ≥ 21 years old, both sexes. Patients were owed into two groups according to RDW levels: Group A (n=35): normal RDW …
Investigating The Role Of Traditional Chinese Herbal Medicine For Cancer Symptom Management In Older Adults: A Rapid Review, Isabelle C. Karshner
Investigating The Role Of Traditional Chinese Herbal Medicine For Cancer Symptom Management In Older Adults: A Rapid Review, Isabelle C. Karshner
Honors Undergraduate Theses
Background: Patients with cancer often experience symptoms related to disease, complications, and treatment. One potential method of alleviating these symptoms is traditional Chinese herbal medications (TCHM). This rapid review explores the role of traditional Chinese herbal medications in treating cancer-related symptoms in older adults.
Purpose: The purpose of this rapid review is to gain and provide a better understanding of the effects of TCHM on cancer-symptom management in the older adult population. This review explores the association between TCHM and effects on cancer symptoms in older adults, including interactions, toxicity, and signs/symptoms of TCHM use that may be useful information …
Evaluation Of Electroencephalography Processing Methods For Estimating Metabolic Energy Expenditure During Walking, Stephanie L. Pinelo
Evaluation Of Electroencephalography Processing Methods For Estimating Metabolic Energy Expenditure During Walking, Stephanie L. Pinelo
Graduate Studies Theses and Dissertations 2026
In this study, three EEG datasets, created via different levels of pre-processing, were used to train VO2 prediction models whose performance was tested and compared. Understanding the link between EEG and VO2 during walking is important when working in rehabilitation or studying metabolic energy optimization. Common methods of measuring these two bio-signals tend to be bulky, uncomfortable, and inefficient, so finding a way to predict VO2 from EEG via 1D CNN model training is a worthy pursuit. It was hypothesized that, due to a CNN needing more data to find patterns for prediction, a minimally processed EEG dataset would have …
Monitoring Shifts In Estuarine Microbial Communities: A Dna-Metabarcoding Approach, Ashley M. Reaume
Monitoring Shifts In Estuarine Microbial Communities: A Dna-Metabarcoding Approach, Ashley M. Reaume
Graduate Studies Theses and Dissertations 2026
Estuarine microbial communities, including plankton, algae, and bacteria, play important roles in nutrient cycling and food web structure. They are sensitive to changes in abiotic conditions, and shifts in community composition can provide insight into estuarine ecosystem functioning in the face of various physiochemical and anthropogenic stressors. Therefore, monitoring these communities is essential for understanding and maintaining estuarine health. DNA metabarcoding is an emerging technique for enhancing biological monitoring, allowing for the detection of multiple species within a single sample. This dissertation first focuses on how methodological decisions impact DNA metabarcoding results and then implements these optimized methods to perform …
Exercise-Induced Muscle Swelling And Impedance Changes Of The Elbow Flexor, Sofea Smith
Exercise-Induced Muscle Swelling And Impedance Changes Of The Elbow Flexor, Sofea Smith
Graduate Studies Theses and Dissertations 2026
Electrical impedance myography (EIM) is a non-invasive method that assesses body fluid distribution using impedance (Z), resistance (R), reactance (Xc), and phase angle (PhA). These values have previously been used to interpret cellular health and fluid shifts. Acute muscle edema known as a “pump,” has been reported during and after resistance training exercise and the extent to which bioelectrical properties of the muscle tissue are affected during this process remains relatively unexplored. Therefore, the purpose of this study was to assess changes in EIM during exercise-induced muscle swelling via resistance training. Thirty-one resistance-trained adults (male=21, female=10; age=23.4±6.5 years, BMI=26.17±3.04 kg/m2) …
Teachers’ Perceptions Of School Leaders’ Role In Implementing The Four Pillars Of Community Schools For Improving Student Achievement, Adrian Irwin Thomas
Teachers’ Perceptions Of School Leaders’ Role In Implementing The Four Pillars Of Community Schools For Improving Student Achievement, Adrian Irwin Thomas
Graduate Studies Theses and Dissertations 2026
This study examined teachers’ perceptions of school leaders’ roles in implementing the Four Pillars of Community Schools to support Student achievement in under-resourced schools. The four pillars of Community Schools- Integrated Student Support, Expanded Learning Time and Opportunities, Family and Community Engagement, and Collaborative Leadership and Practices- served as the conceptual framework for the study. Distributed Leadership Theory and Epstein’s Framework of Parental Involvement provided the theoretical lens that guided the interpretation of the findings. The study explored teachers’ perceptions of leadership practices associated with the four pillars and identified leadership strategies perceived as most effective for sustaining the community …
Bridging The Gap: How Sociodemographic Factors Shape Adults’ Decisions To Pursue Hearing Aids, Logan Lorié
Bridging The Gap: How Sociodemographic Factors Shape Adults’ Decisions To Pursue Hearing Aids, Logan Lorié
Graduate Studies Theses and Dissertations 2026
Despite hearing aids becoming more accessible to adults with hearing loss, hearing aid uptake rates remain low, partly due to sociodemographic factors that influence an adults’ decision to pursue amplification. This study systematically reviewed research on how sociodemographic factors – to include age, gender, socioeconomic status, education level, race/ethnicity, and military status – contribute to the decision-making process. This review guided an analysis of these variables using the National Health and Nutrition Examination Survey (NHANES), a large public health database. To ensure enough hearing aid users were included in the analysis, NHANES data were combined across survey cycles from 1999 …
Invisible Stress, Visible Patterns: How The Superwoman Schema Shapes Diet And Feeding Practices In Black Mothers And Their Youth During The Summer Versus School Months, Jillian Weathington
Invisible Stress, Visible Patterns: How The Superwoman Schema Shapes Diet And Feeding Practices In Black Mothers And Their Youth During The Summer Versus School Months, Jillian Weathington
Graduate Studies Theses and Dissertations 2026
Background: Black mothers are frequently socialized into the Superwoman Schema (SWS), a coping pattern characterized by self-sacrifice and suppression of personal needs. Alongside significant caregiving demands, SWS may limit healthy eating opportunities, yet its relationship with diet quality (DQ) remains understudied. SWS may also intensify during unstructured summer periods. This study examined associations between SWS, perceived stress, and DQ among Black mothers and their youth during summer (T1) and school months (T2).
Methods: This observational within-subjects study included Black mothers (T1: n=51; T2: n=32; mean age 39.6±6.1) and their youth (mean age 10.6±0.3). Assessments occurred at two timepoints six weeks …
When Fever And Thrombocytopenia Are Not Infectious: A Case Of Vitamin B12 Deficiency Mimicking Tropical Fever, Ram Arvind Viswanathan Dr
When Fever And Thrombocytopenia Are Not Infectious: A Case Of Vitamin B12 Deficiency Mimicking Tropical Fever, Ram Arvind Viswanathan Dr
Digital Journal of Clinical Medicine
Vitamin B12 deficiency is classically associated with megaloblastic anaemia and neurological manifestations; however, atypical presentations continue to pose diagnostic challenges. Fever in association with thrombocytopenia often prompts evaluation for infectious aetiologies such as dengue, malaria, or sepsis, particularly in tropical settings. We report a case of vitamin B12 deficiency presenting with pyrexia and isolated thrombocytopenia, initially suspected to be an infectious illness. Extensive evaluation failed to reveal an infective cause, and subsequent haematological workup demonstrated megaloblastic changes with low serum vitamin B12 levels. Remarkably, the patient showed rapid defervescence and normalisation of platelet counts following parenteral vitamin B12 therapy. This …
Dietary Micronutrients And The Risk Of Gestational Diabetes: Evidence From A Tertiary Care Setting In India, Sujatha Mahadevarao Premnath, Moneesh Sivasoupramaniane, Maghida S
Dietary Micronutrients And The Risk Of Gestational Diabetes: Evidence From A Tertiary Care Setting In India, Sujatha Mahadevarao Premnath, Moneesh Sivasoupramaniane, Maghida S
Digital Journal of Clinical Medicine
Background: Gestational Diabetes Mellitus (GDM) is a significant health concern in India, affecting nearly 22.4% of pregnant women. While macronutrient roles are well explored, the impact of micronutrients on GDM risk, particularly with the Indian ethnic phenotype, requires exploration
Objectives: To compare the micronutrient intake between GDM and non-GDM pregnancies and evaluate the association between specific dietary micronutrients and GDM risk
Methods: An observational cross-sectional study was conducted among 115 South Indian pregnant women. Dietary history was taken using 24-hour recalls on two occasions and analysed via the Indian Food Composition Table (IFCT). GDM was diagnosed using International Association of …
Examining Mental Healthcare Underutilization Among Latino Immigrants: Healthcare Providers’ And Community Health Workers' Perspectives, Geovani Muñoz
Examining Mental Healthcare Underutilization Among Latino Immigrants: Healthcare Providers’ And Community Health Workers' Perspectives, Geovani Muñoz
Theses and Dissertations
Latinos continue to experience many logistical and systemic barriers to professional mental health services (Derr, 2016) despite being the second-largest racial-ethnic group in the United States (U.S.). With a community of 65 million people (U.S. Census Bureau, 2024), Latinos experience mental healthcare inequalities (Cook et al., 2019) due to structural, cultural, and systemic barriers. Although prior research has emphasized culturally responsive care as a pathway to reducing disparities (Nagy et al., 2025), much of the literature has focused on Western medical models, with limited attention to community-based perspective. Guided by the Knowledge, Attitude, and Practices (KAP) framework, the present study …
Dietary Acculturation, Dietary Inflammatory Potential, And Metabolic Syndrome Among Immigrants In The United States: A Mixed-Methods Approach Using Nhanes And Qualitative Data, Esse G. Foka Nzaha
Dietary Acculturation, Dietary Inflammatory Potential, And Metabolic Syndrome Among Immigrants In The United States: A Mixed-Methods Approach Using Nhanes And Qualitative Data, Esse G. Foka Nzaha
Theses and Dissertations
Background and Objectives: Immigrants in the United States undergo acculturation — a process of sociocultural and behavioral adaptation to the host country. Increasingly, behavioral adaptations have been associated with cardiometabolic health and chronic disease risk. Metabolic syndrome (MetS), a cluster of conditions including abdominal obesity, elevated blood pressure, impaired fasting glucose, elevated triglycerides, and reduced HDL cholesterol, is a major risk factor for type 2 diabetes mellitus, cardiovascular diseases and other chronic diseases, including cancer. Despite the growing immigrant population in the U.S., the role of diet and dietary acculturation in MetS development remains poorly understood in this population. This …
24-H Circadian Rest-Activity Rhythms And Physical Frailty In Older Adults: A Biopsychosocial Perspective On Sex Differences And Social Capital, Jisu Kim
Theses and Dissertations
Physical frailty is a prevalent geriatric syndrome characterized by age-related decline across multiple physiological systems. Physical frailty is associated with an elevated risk of adverse health outcomes, including chronic disease progression and all-cause mortality, representing a significant and growing public health concern. Disrupted circadian rest-activity rhythms (RARs) are increasingly recognized as clinically meaningful markers of physical frailty in older adults. However, the extent to which biological sex and social determinants of health (SDoH), particularly social capital, contribute to or modify the associations between RARs and physical frailty remains underexplored.
Therefore, this dissertation summarizes the existing literature on age-related changes in …
Vitality: Wellness For Female Collegiate Athletes, Kristin Beach
Vitality: Wellness For Female Collegiate Athletes, Kristin Beach
Theses and Dissertations
Vitality is a wellness center for female collegiate athletes. It is rooted in female oriented design strategies for comfort, recovery, and wellbeing. This project aims to provide an inclusive environment in which women within the VCU athletics department can come and support their health and wellbeing. Spaces include physical therapy, academic support, movement studios, gathering lounge, locker room, private therapy, and grab and go food options. This program aims to provide spaces that support the busy schedule of a collegiate athlete, while using design strategies that enhance social, mental, and physical wellbeing while visiting. Located in a historic sauers building, …
Dietetic Guidance For Nutritional Management Of People With Phenylketonuria Receiving Sepiapterin, Anita Macdonald, Kirsten Ahring, Alexa Bledsoe, Hiroki Fujimoto, Sara Giorda, Christian Kogelmann, Jessica Kopesky, Laura Nagy, Sara O'Neill, Alex Pinto, Soraia Poloni, Paige Roberts, Annemiek M J Van Wegberg, Suzanne Hollander
Dietetic Guidance For Nutritional Management Of People With Phenylketonuria Receiving Sepiapterin, Anita Macdonald, Kirsten Ahring, Alexa Bledsoe, Hiroki Fujimoto, Sara Giorda, Christian Kogelmann, Jessica Kopesky, Laura Nagy, Sara O'Neill, Alex Pinto, Soraia Poloni, Paige Roberts, Annemiek M J Van Wegberg, Suzanne Hollander
Faculty, Staff and Student Publications
Background/objectives: Phenylketonuria (PKU) is an autosomal recessive inborn error of metabolism. If untreated, elevated blood phenylalanine (Phe) levels lead to neurological and behavioral impairments. Phe levels can be managed through a lifelong Phe-restricted diet; however, this can be challenging to maintain. Sepiapterin is an adjunct therapy for PKU that has shown efficacy in reducing blood Phe levels in both tetrahydrobiopterin (BH4)-responsive and BH4-non-responsive people with PKU in clinical trials. Practical guidance is needed for dietitians and other healthcare professionals supporting the dietary management of people with PKU who are initiating or receiving sepiapterin.
Methods: A group of international dietitians participated …
Dynamics Of Household Food Insecurity Vulnerability: Examining Health, Functional Limitations, And Income Stability, Renita Washburn
Dynamics Of Household Food Insecurity Vulnerability: Examining Health, Functional Limitations, And Income Stability, Renita Washburn
Graduate Studies Theses and Dissertations 2026
Household food insecurity is a multidimensional issue affecting millions of households in the United States. While research has established that low income and poor health or functional limitations can increase the risk of food insecurity, current approaches do not fully capture these dynamic processes to identify long-term vulnerability. Specifically, income-based measures rely on static thresholds that miss instability, potentially underestimating risk. Gaps also remain in understanding persistent food insecurity, including how functional limitations (difficulties with activities like bathing, shopping, or managing finances) are associated with insecurity over time. These functional limitations can impact both economic factors (such as the ability …
Site Use And Demographic Changes In A Northwest Atlantic Sea Turtle Foraging Ground, Ryan C. Welsh
Site Use And Demographic Changes In A Northwest Atlantic Sea Turtle Foraging Ground, Ryan C. Welsh
Graduate Studies Theses and Dissertations 2026
and site fidelity, making mortality difficult to distinguish from redistribution. We developed a behaviorally explicit framework to separate true mortality from changes in availability caused by movement and redistribution. We evaluated this problem for juvenile green turtles (Chelonia mydas) and loggerhead turtles (Caretta caretta) captured at the St. Lucie Nuclear Power Plant intake canal on Florida’s Atlantic coast using a multi-decade capture–mark–recapture record spanning 1977 - 2023. Hidden Markov Models classified individuals into latent habitat-use strategies (Nomadic, Resident, and Transient) based on capture timing and body size. Across both species, these strategies captured consistent differences in site fidelity and recapture …
Amustaline/Glutathione Pathogen-Reduced Red Cell Hemoglobin Utilization In Complex Cardiac Surgery, Ian J. Welsby, Michael E. Sekela, Edward L. Snyder, James D. Gorham, John S. Mcneil, Kathy Liu, Stanley Bentow, Thomas Gniadek, Laurence Corash, Nina Mufti, Richard J. Benjamin
Amustaline/Glutathione Pathogen-Reduced Red Cell Hemoglobin Utilization In Complex Cardiac Surgery, Ian J. Welsby, Michael E. Sekela, Edward L. Snyder, James D. Gorham, John S. Mcneil, Kathy Liu, Stanley Bentow, Thomas Gniadek, Laurence Corash, Nina Mufti, Richard J. Benjamin
Surgery Faculty Publications
Background: The ReCePI randomized, controlled trial compared amustaline/glutathione pathogen-reduced (PR) and conventional red blood cell (RBC) transfusions in cardiac surgery. Study design and methods: We performed a post-hoc analysis of hemoglobin (Hb) utilization and safety outcomes. Hb content of study RBCs was measured at manufacture. Subject Hb levels, estimated blood loss and blood product use were recorded during and for 7 days post-surgery. Acute kidney injury (AKI) incidence was graded over 7 days, and adverse events were assessed for 28 days. Results: PR-RBCs contained 5.2% less Hb (mean [SD] Test 58.1 [6.5] g; Control 61.5 [6.8] g Hb, p <.001) due to manufacturing volume losses. Four hundred fifty-six PR- and 524 conventional RBCs were transfused to 159 Test and 162 Control subjects, respectively. Mean subject baseline and post-surgery Hb levels, and blood loss were not different between groups. Test subjects tended to require fewer total RBCs (3.5 [2.7] Test vs. 4.0 [3.5] Control, p =.08) resulting in 17.6% significantly less mean total Hb transfused (Test 203.2 g; Control 246.8 g Hb, p =.01). The proportions of subjects transfused with, and the number of platelet and cryoprecipitate units transfused were not different. Test subjects received less plasma (2.3 [1.8] units Test vs. 3.5 [3.8] Control, p =.03). Overall incidence of adverse events and AKI were not clinically different. Imbalances in AKI severity (Grade III Test 15/159 [9.4%]; Control 7/162 [4.3%], p =.07) may suggest under-transfusion in the highest-risk Test subjects. Discussion: Test patients required less transfused Hb than control subjects to maintain equivalent daily hemoglobin levels following similar blood loss.
Mouse Models For Post-Sepsis Syndrome, John Matthew K. Ang, Stephanie F. Mori, Erick Lewis, Maria E.C. Bruno, Arnold Stromberg, Hiroshi Saito
Mouse Models For Post-Sepsis Syndrome, John Matthew K. Ang, Stephanie F. Mori, Erick Lewis, Maria E.C. Bruno, Arnold Stromberg, Hiroshi Saito
Surgery Faculty Publications
Background – Sepsis survivors commonly suffer from chronic Post-Sepsis Syndrome (PSS). To understand the mechanisms of PSS, it is critical to utilize appropriate animal models. While cecal ligation and puncture (CLP) is a widely used model of sepsis, a concern exists regarding its suitability for studying long-term outcomes. Alternatively, we previously optimized a highly reproducible murine cecal slurry (CS)-injection model of sepsis. The objective of this study was to compare the suitability of CS and CLP models for investigating PSS. Methods – Male 4-month-old C57BL/6 mice were divided into 7 groups: (1) Naïve control; (2) Sham: laparotomy control; (3) CL: …
Symbolic Logistic Regression For Interval-Valued Predictors: A Simulation Study And Application To Health Data, Soad Abdullah
Symbolic Logistic Regression For Interval-Valued Predictors: A Simulation Study And Application To Health Data, Soad Abdullah
Graduate Research Theses & Dissertations
This thesis investigates symbolic logistic regression for interval-valued predictors through simulation studies and a real health data application. Classical logistic regression assumes exact predictor values, whereas in many practical settings variables are available only in interval form due to coarsening or reporting uncertainty. Two simulation studies examine the impact of interval uncertainty under asymmetric intervals and measurement error. Symbolic models based on midpoint and midpoint-plus-width representations are compared with the classical approach. Results show that midpoint modeling captures the general relationship but introduces bias under asymmetry, while incorporating width reduces this distortion. Under measurement error, classical logistic regression exhibits attenuation …
Identifying Maltreatment Classes And Their Associated Psychological Outcomes From Childhood To Adolescence, Colleen Bartlett
Identifying Maltreatment Classes And Their Associated Psychological Outcomes From Childhood To Adolescence, Colleen Bartlett
Graduate Research Theses & Dissertations
Previous research has consistently shown that experiencing maltreatment has significant, negative effects on youth’s psychological health; however, research on the psychological impact of maltreatment is often limited by challenges in accurately capturing children’s maltreatment experiences, as most children who are exposed to maltreatment experience multiple types of maltreatment. The present study utilized latent class analyses (LCAs), a person-centered, data-driven approach to empirically identify patterns in children’s maltreatment experiences at ages 3, 5, and 9. Maltreatment class indicators included frequency of behaviorally approximated emotional abuse, physical abuse, and neglect. Following the LCAs, associations between maltreatment class membership and youth internalizing and …
Application Of Paper Spray Mass Spectrometry For Screening Acetylcholinesterase Inhibitors, Diksha Gautam
Application Of Paper Spray Mass Spectrometry For Screening Acetylcholinesterase Inhibitors, Diksha Gautam
Graduate Research Theses & Dissertations
Paper spray mass spectrometry (PS-MS) is a novel ambient ionization method that allows chemical and biological samples to be rapidly analyzed with little preparation being required. In this paper, PS-MS was set up and streamlined as an acetylcholinesterase (AChE)-monitoring platform in addition to screening an existing and newly produced AChE-inhibitors. The detection of the substrate, acetylcholine (m/z 146), and the AChE catalysis product, choline (m/z 104) was performed without applying chromatographic separation or derivatization to the dried paper substrates. Assay conditions were optimized in a systematic way, to develop a robust MS-compatible enzymatic workflow.
Calibration curves for both, acetylcholine and …