Digital Commons Network^™

Forage Legume Community Dynamics In Response To Stand Management, Nicholas Warren

Doctoral Dissertations

A primary challenge for perennial forage production systems is maintaining crop productivity and forage quality over time. Including legume species in these systems is an opportunity to reduce external inputs, to extend the seasonal productivity of a pasture, and to balance the nutritional characteristics of grass species. However, legume persistence in mixed stands is frequently poor. Identifying harvest practices, legume species, or species mixtures that improve legume persistence would help to maximize the ecosystem services of forages. I conducted a four-year field experiment (2019 to 2022) in southeastern New Hampshire to evaluate the productivity and persistence of four perennial legumes …

Mitochondrial Efficiency: Bridging Early-Life Environment And Organismal Performance, Kayla E. Lichtner

Master’s Theses

Mitochondria operate at the forefront of organismal-environmental interactions. Despite remarkable diversity in mitochondrial function both within and among species, all mitochondria serve a universal role in facilitating the flow of energy between organisms and their environment. Energetic efficiency, the way in which organisms assimilate and transform environmental substrate into physiological currency, is a major determinant of organismal performance. Although previous studies have shown that early-life environment can have lasting effects on metabolism, the underlying mechanisms driving the emergence of mitochondrial phenotypic variation remain poorly understood. Leach’s storm-petrels (Hydrobates leucorhous) provide a valuable opportunity to investigate longitudinal hypotheses of …

Research News, Publications, 2026, Volume 2, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of April 1 - June 30, 2026.

Research News, Publications, 2026, Volume 1, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of January 1 - March 31, 2026.

Ethanol And Iron Absorption Interactions Within Crayfish Invertebrate Models, James Rollman, Andrew Wissmar

Williams Honors College, Honors Research Projects

Analysis of the effects of alcohol consumption (ethyl-alcohol) on iron absorption within crayfish model. The use of tube-feeding provides a novel, more precise output, and less invasive procedure compared to the traditional approach of dissolving the target substance in tank water and measuring hemolymph changes. The project aims to determine the extent to which alcohol influences iron absorption. Ultimately, the choice of iron reflect the future potential to aid in research with genetic hemochromatosis and or Iron overload.

The Connection Between Medicaid And Obesity In Northeast Ohio, Emmie Kelley, Sophie Kheder

Williams Honors College, Honors Research Projects

Obesity is a major public health concern in the United States that is projected to increase exponentially over the next few years. Obesity is commonly associated with a lower socioeconomic status. Lower-income individuals tend to be supported by Medicaid, a federal insurance program for low-income Americans. Prior studies have shown a positive correlation between income status and obesity prevalence. Our goal was to find if there was a correlation between Medicaid patients and obesity in Northeast Ohio, to provide physicians with a set of characteristics to better combat obesity, since preventative and treatment guidelines are tailored to national trends. We …

Physiological Development Of Hypertension As A Result Of High-Fat Diet Induced Obesity, Michael Nguyen

Williams Honors College, Honors Research Projects

This literature review focuses on the physiological development of obesity due to the consumption of diets rich in fats and the resulting pathophysiological development of hypertension. This review aims to identify causes of obesity and hypertension as well as current treatments to propose future areas of study. The literature review analyzed a wide variety of literature sources on obesity and hypertension published between the years 1995 and 2025. The review identifies high-fat diets as a cause of obesity and the resulting health effects of elevated leptin, insulin, and nervous system activity as contributors to the development of hypertension. Future areas …

Abuse Of Contract: A Proposal For A New Cause Of Action, Miriam A. Cherry

Faculty Publications

With the growth of online commerce and the platform economy, many companies are including provisions in their online terms and conditions that extend far beyond what reasonable consumers would expect. Some terms and conditions purport to bind customers to separate contracts in future transactions that have little to do with the first contract. Other boilerplate purports to cover family members of the customer who created an account. Some retailers have argued that people shopping in their brick-and-mortar stores are subject to terms and conditions because those shoppers had at some point previously created an online account. For example, Disney argued …

“Full And Equal Access”: A Socio-Ecological Model Of Healthcare Ableism Experienced By The Blind And The Low Vision Community, Rebecca Fischbein, Rachel Conrad Bracken, Allyson S. Hughes, Rayyan Bhutta, Nazanin M. Heydarian

School of Social Work Faculty Publications

In 2023, the National Institutes of Health (NIH) designated people with disabilities as a population experiencing health disparities, citing “a wide and varying range of health conditions leading to poorer health and shorter lifespan” and “discrimination, inequality and exclusionary structural practices” contributing to pervasive health inequities. As blindness and low vision (BLV) become increasingly common due to an aging population coupled with higher rates of type 2 diabetes, more people who are BLV will require quality care. Yet, people who are BLV face many barriers to care, including healthcare provider and staff (HCP) ableism. In this chapter, we propose a …

Physiological Leptin Replacement Does Not Reverse Metabolic Adaptations To Starvation In Sprague Dawley Rats, Sydney Junot, Layla Deprimo, Camille Meaux, Arline Narez, David Mcdougal

Distinguished Undergraduate Researcher Program

Historically, low insulin levels were the signaling event considered responsible for metabolic adaptations to starvation, such as increased sympathetic outflow and increased serum levels of ketones, glucagon, and free fatty acids. Leptin, a hormone produced by adipose tissue, is known to decrease in response to caloric restriction. Recent work in the field suggested that leptin infusion in the final hours of a 48-hour fast reversed all metabolic adaptations to starvation, thus raising questions about an underappreciated role of leptin in the starvation response. This study tested whether physiological leptin replacement, maintaining fed plasma leptin concentrations, during a 72-hour fast in …

Memory For Everyday Chores In Younger And Older Adults, Cameron Mccleary, Katie Cherry

Distinguished Undergraduate Researcher Program

This study examined episodic memory performance for everyday household chores in younger (18-32 years) and older adults (65-79 years). With the increasing older adult population in the United States, understanding age-related memory differences and identifying strategies to enhance memory performance in later life is needed. Building on previous research demonstrating the pictorial superiority effect and benefits of semantic encoding across the adult lifespan, this study utilized a 2 × 2 × 2 between-groups factorial design to investigate the effects of age group (younger, older), encoding task (standard intentional learning, semantic elaboration), and stimulus format (text only, text with pictorial illustrations) …

Evaluation Of Liberty® Herbicide For Zygosity Verification In Transgenic Maize (Zea Mays) Expressing The Bar Gene From Streptomyces Hygroscopicus, Isabel Hau

Distinguished Undergraduate Researcher Program

Maize (Zea mays) is a major global crop cultivated for food and feed. Most commercial varieties grown in the United States contain herbicide-resistant traits to facilitate weed management. One such herbicide trait is Liberty-Link, which contains the bialaphos resistance (bar) gene from Streptomyces hygroscopicus that confers resistance to glufosinate-ammonium, the active
ingredient in Liberty herbicide. This bar gene is also widely used as a selectable marker in plant transformation. In non-transgenic plants, glufosinate-ammonium inhibits plant glutamine synthetase by acting as a glutamate analog, thereby disrupting amino acid biosynthesis and leading
to plant death. In contrast, transgenic plants expressing the bar …

Measuring The Rise And Fall Of Plasma 25-Hydroxyvitamin D Concentrations In Blue-Tongued Skinks (Tiliqua Scincoides) Following Ultraviolet B Exposure And Withdrawal, Ashleigh Godke, Haerin Rhim, M. Graciela Aguilar, Keishla Marrero-Acosta, Mark Mitchell

Distinguished Undergraduate Researcher Program

Species-specific husbandry guidelines remain limited for blue-tongued skinks (Tiliqua scincoides), especially in relation to ultraviolet B (UVB) lighting and vitamin D requirements. This study aimed to determine whether UVB exposure is necessary for these skinks and how long 25-hydroxyvitamin D (25-OHD) concentrations persist after UVB withdrawal. Eleven adult skinks who had been fed with wet cat food were exposed to 12 or 2 h of UVB per day for four weeks. Plasma 25-OHD concentrations were very low at the baseline, and significantly increased post-UVB in both groups (p < 0.01), with the 12-hour group increasing from baseline concentrations of 18.5 [12.8–20.5] nmol/L to 820 [730–1251.3] nmol/L and the 2-hour group increasing from baseline concentrations of 22 [15.5–22] nmol/L to 635 [401–892.5] nmol/L. Following the discontinuation of UVB exposure, 25-OHD gradually declined and was not significantly different from baseline concentrations at 7 and 4 months for the 12-hour and 2-hour groups, respectively. Dietary vitamin D3 (2.5 IU/g as dry matter basis), provided through wet cat food alone, appeared insufficient to support sustained plasma 25-OHD concentrations. These findings strongly suggest that blue-tongued skinks rely on UVB exposure to increase their 25-OHD concentrations. Moreover, the shorter 2-hour exposure provided a significant rise in 25-OHD concentrations and remained above baseline for 4 months, suggesting the shorter exposure can benefit these animals, while potentially reducing secondary risks associated with UVB exposure.

Gullah Geechee, Progenitors For African North American Maternal Lineage, Jennifer Caldwell, Imani Sykes, Robbie Beyl, Tomilowo Abijo, Kiara Charles, Fatimah Jackson

Distinguished Undergraduate Researcher Program

African American ancestral lineages are marked by resilience, shaped by centuries of forced migrations, the Transatlantic and domestic slave trades, and subsequent movements within the United States. These historical events have influenced both the cultural and genetic diversity of Legacy African Americans. This study examined mitochondrial DNA (mtDNA) haplogroups among 189 participants—79 Gullah Geechee and 110 African Americans—to explore the Gullah Geechee as potential progenitors of other Legacy African North American lineages. Haplogroup analysis revealed L2 and L3 as the most frequent among both groups, comprising 34.6% and 38.8% in African Americans and 28.0% and 54.7% in Gullah Geechee, respectively. …

A Quality Improvement Project: Enhancing Nursing Knowledge And Patient Safety In The Prevention Of Hospital-Acquired Pressure Injuries (Hapis) In A Medical-Surgical Unit, Kristen Vartabedian

Master's Theses and Capstones

Background: Hospital-acquired pressure injuries (HAPIs) are a significant quality indicator within the hospital system. HAPIs increase hospitalization, morbidity, and associated healthcare costs. The current evidence suggests that ongoing nursing education can improve pressure injury prevention and help in the early identification.

Local Problem: Nurses within a medical-surgical unit demonstrated a gap in knowledge in the identification of hospital acquired pressure injuries and lack of accuracy when charting skin findings. Thus, contributing to a delay in recognition and treatment of HAPIs.

Methods: This quality improvement project utilized the Plan-Do-Study-Act (PDSA) framework to guide implementation of educational flipbooks. Materials contained standardized wound …

Reducing Readmissions For Copd Through Improved Education: A Gap Analysis, Raphael Gaughan

Master's Theses and Capstones

No abstract provided.

Improving Efficiency In The Intensive Care Unit Through Reduction Of Nurse Burnout: A Quality Improvement Initiative, Johanna Grace Koroma

Master's Theses and Capstones

Abstract

Background: Intensive care unit (ICU) nursing is prone to high levels of burnout, which poses concern for staff wellbeing, patient safety, and microsystem strain (Kerlin et al., 2020). Educational interventions may serve as a means of increasing awareness on the issue and reducing the effects of burnout, through promotion of evidence-based management strategies.

Local Problem: One ICU microsystem identified several key contributing factors to nurse burnout, including staffing shortages, limited resources, competing responsibilities within the macrosystem, and insufficient organizational support (Zhang et al., 2025). Baseline survey data of the population observed a prevalence of 50% “high” burnout profiles among …

Introducing Education For Sensory Approaches In Mental Health-Related Emergency Department Visits: A Quality Improvement Project To Enhance Patient-Centered Care, Jesse O'Neill

Master's Theses and Capstones

Background: Barriers to specialty care access have resulted in emergency departments (ED) operating as temporary psychiatric hold facilities for their communities. Patients boarding in the ED are demonstrated to use a disproportionate percentage of facility resources with minimal benefit to the patient. The Institute for Healthcare Improvement identifies the impact of the healthcare environment on patient outcomes and suggests staff training to foster trauma-informed practice culture (Schall et al., 2020).

Local Problem: High-stress healthcare environments can escalate maladaptive patient behaviors and the use of restrictive interventions. Traditional use of restrictive interventions lacks supportive evidence and contradicts person-centered care goals (Molloy …

Pediatric Chop Chemotherapy Acutely Disrupts Satellite-Cell Dynamics And Blunts Muscle Mass In A Sex-Specific Manner, Jainil Daredia, Marc A. Magaña, Carla M.C. Nascimento, Jaden M. Wells, Nicholas T. Thomas, Yuan Wen, Savannah V. Rauschendorfer, Cory M. Dungan, Michael P. Wiggs

Physiology Faculty Publications

Pediatric cancer survival now exceeds 85% owing, in part, to advances and the use of combination chemotherapy treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone). Despite its efficacy, CHOP may cause off-target effects during critical pediatric development periods such as impairments of skeletal muscle. We evaluated the acute effects of a CHOP administered to C57Bl/6J mice from postnatal day 28 to 48. CHOP slowed body-weight gain and led to a smaller gastrocnemius fiber cross-sectional area by ~25% in both sexes (n ¼ 11 or 12 males; n ¼ 8 or 9 females). RNA sequencing detected 214 differentially expressed genes …

Skeletal Muscle Methylome-Transcriptome Disruptions During The Onset And Progression Of Colorectal Cancer-Induced Cachexia, Ana Regina Cabrera, Ronald G. Jones, Eleanor R. Shrems, Francielly Morena, Yuan Wen, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene

Physiology Faculty Publications

Cancer cachexia is a wasting condition, primarily affecting skeletal muscle, impairing patients’ quality of life, prognosis, and survival. The molecular triggers are incompletely defined, but given prior evidence for epigenetic plasticity in muscle, we speculate that dysregulated DNA methylation plays a role in muscle transcriptional alterations mediating cachexia severity. We aimed to describe and integrate the cachexia methylome and transcriptome. We used a time course approach in a mild cachexia model (colon-26, C26) coupled with a severe cachexia genetic model (Apc^Min/+) in both biological sexes to assess the methylome across degrees of cachexia pathology. The muscle methylome and …

A Zinc Chelate Of Lysine/Glutamic Acid Reduces Alcohol-Induced Ciliary Dysfunction, Emily Do, Daren L. Knoell, Christopher Bauer, Deanna Mosley, Deandra R. Smith, Derrick R. Samuelson, Todd A. Wyatt

Journal Articles: Environmental, Agricultural & Occupational Health

Alcohol misuse is a known risk factor for pneumonia, and up to 50% of individuals who misuse alcohol are zinc deficient. Chronic alcohol misuse can lead to alcohol-induced ciliary dysfunction (AICD), preventing effective mucociliary clearance and protection against lung infection. Because zinc salts fail to alter AICD, we hypothesized a form of zinc (Zinpro Zinc LG) with enhanced cell uptake would protect against AICD. Human and mouse airway epithelial cells were treated with 50 mM ethanol for 1-24 h followed by the ciliostimulatory agents. Cilia beat frequency (CBF) and cAMP-dependent protein kinase (PKA) activity were assayed. Cyclic AMP or beta …

The Subadults Of Casas Grandes: A Bioarchaeological Study, Holli Kaye Mcdonald

Graduate Student Theses, Dissertations, & Professional Papers

Across the span of nearly eight hundred years, from AD 700-1450, the societies of the Casas Grandes region waxed and waned and left an astounding representation in the archaeological record. Best-known through the temporally older site of Convento (occupied during what is known as the Viejo Period) and the later site of Paquimé (occupied during the Medio Period), gradual cultural expansion and florescence across this period are witnessed through a variety of findings across decades of anthropological investigation.

Along with the artifacts and architecture unveiled during initial excavations at Paquimé and Convento, remains of 654 individuals were catalogued as well. …

Fit Ideal Internalization And Muscularity-Oriented Disordered Eating Among College Women: Examining Social Comparisons And Body Dissatisfaction As Serial Mediators, Nicole Graumann

West Chester University Graduate Theses, Dissertations, and Final Projects

Muscularity-oriented disordered eating (MODE) comprises rigid eating behaviors driven by a desire to be toned and muscular (Cunningham et al., 2021; Murray et al., 2019). While MODE has been widely studied among men, it is increasingly prevalent among women, and it is vital to explore its associated risk factors. In particular, the fit ideal (thin but also toned) is an emerging issue among women’s body image and could be a factor for women engaging in MODE; however, there is limited research exploring this relationship. The present study examined the relationship between the fit ideal internalization and MODE among college women …

Caring For Your Heart During Survivorship After Pediatric Cancer: A Visual Education Guide On Chemotherapy-Induced Cardiotoxicity, Bryona Rose Hamilton

Theses

Chemotherapy is an effective weapon in the fight against pediatric cancer. However efficient, treatment can lead to side effects that last long after a patient finishes their last round of chemotherapy. This thesis examines current research on chemotherapy-induced cardiotoxicity, a side effect of chemotherapy treatment caused by a class of chemotherapy drugs called Anthracyclines (such as doxorubicin and daunorubicin). While effective chemotherapy agents, these drugs have been known to cause late long-term heart damage when used to treat pediatric cancers such as Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML) and Pediatric Sarcoma. A written portion of this thesis project …

Women Shellfishers’ Role In Managing ‘Women’S Forest’ And Conservation Challenges In Youtefa Bay, Indonesia, Helmawaty E. Rumbiak

Open Access Master's Theses

Mangrove forests in Youtefa Bay hold critical ecological and cultural significance for the Enggros community, particularly for women. Known as the “women’s forest,” this area is where Enggros women harvest shellfish and collect firewood. Women shellfishers have a close relationship with the forest, where they connect with their children and other women. However, rapid urban development and pollution around the mangrove ecosystem have negatively impacted the women shellfishers and their role in managing the mangrove forest. Shellfishing activity will likely decrease as urban development around the forest increases, and more waste flows into the forest. This research examines the role …

Pullulan Production From Lignocellulosic Plant Biomass Or Starch-Containing Processing Coproduct Hydrolysates, Thomas P. West

Faculty Publications

The complex polysaccharide pullulan is characterized as a glucose-containing biopolymer that is both water-soluble and neutral in polarity. A variety of commercial applications exist for pullulan, including its utilization as a flocculant, a blood plasma substitute, a food additive, a dielectric material, an adhesive, or a packaging film. The fungus Aureobasidium pullulans has used several hydrolysates derived from plant biomass or starch-containing processing coproducts to support polysaccharide production. These include various plant biomass or processing coproduct streams such as lignocellulosic-containing peat, prairie grass, stalks, hulls, straw, shells, and pods or starch-containing coproducts from the processing of corn, rice, jackfruit seeds, …

Combining Crispr And Nanoasv To Uncover The Rare Bacterial Communities Of The Human Oral Microbiome, Gilma Ruth Sevilla Alvarez

Master's Projects

Studying the oral microbiome is vital because its health implications are not contained to the mouth. Cariogenic bacteria cause tooth demineralization and oral microbes that translocate to extra-oral organ systems are linked to conditions like Alzheimer’s disease, heart disease, diabetes, and cancer. Some of these pathogens belong to the most abundant phyla in the oral cavity: Bacillota, Pseudomonadota, Bacteroidota, Actinomycetota, Spirochaetota, and Fusobacteriota, which together comprise 94% of the oral microbiome. This project uses CRISPR-Cas9 to deplete sequences from highly abundant phyla and the Eubacteria domain, enriching the remaining 6% of rarer taxa. Paired with NanoASV for single-nucleotide resolution, this …

Stem-Fit And Soil-Fit: Integrated Plant And Soil Nitrogen-Hormone Sensing With Machine Learning-Based Forecasting For Next-Generation Precision Agriculture, Nafize I. Hossain, Mohammad Solaiman, A.K.M. Ahsanul Habib, Md Al Mahmud Hossain Al Hadi, Shawana Tabassum

Electrical Engineering Faculty Publications and Presentations

Inefficient fertilizer application in agriculture leads to reduced crop productivity, nutrient losses, and reduced crop resilience, highlighting the urgent need for real-time monitoring of plant–soil nutrient and stress dynamics. This research aims to develop and validate a multiplexed sensing platform for real-time, in-situ measurement of key soil nutrients (Soil-FIT) and plant phytohormones (Stem-FIT) involved in nitrogen signaling and stress regulation. The proposed sensor suite integrates 3D-printed modules for continuous monitoring of nitrate, ammonium, and pH in both soil and plant sap, along with salicylic acid (SA), indole-3-acetic acid (IAA), methyl jasmonate (MeJA), and ethylene (ET) in plant sap. The sensors, …

Shifting Attitudes Toward Healthy Food Choices In Schoolchildren, Krishna Nemali

Purdue Extension Numbered Publications

Nearly a third of Indiana children ages 10 to 17 are overweight or obese. Healthier food choices could make a difference. This publication details what happened when a Purdue professor coupled experiential learning (gardening) with a plant sciences curriculum in a rural Indiana intermediate school.

Bovine Colostrum And Late-Onset Sepsis In Premature Infants: A Multicenter Randomized Controlled Trial (Bcsp Study), Hany Wifky Gendy Michael, Hassan Mohamed Hassan Mohamed, Dalia Abu Elmaaref Mohamed Ibrahim

Journal of Medicine in Scientific Research

Aim: Neonatal sepsis and necrotizing enterocolitis (NEC) have a great impact on morbidity and mortality in immature newborns. We performed our trial to examine the impact of enteral bovine colostrum administration upon late neonatal sepsis in premature newborns. Patients &Procedures: The study included neonates who had a birth weight (BW) of 1-1.8 kg, a gestational age (GA) of full 28-34 weeks, and a postnatal age of ≤ 96 hours. A blinded, randomized, placebo-controlled study was done using two groups; one of them received bovine colostrum daily within the first 96 hours starting from the 2nd day of feeding and for …