Digital Commons Network^™

Human Pancreatic Microenvironment Promotes Β-Cell Differentiation Via Non-Canonical Wnt5a/Jnk And Bmp Signaling, Jolanta Chmielowiec, Wojciech J Szlachcic, Diane Yang, Marissa A Scavuzzo, Katrina Wamble, Alejandro Sarrion-Perdigones, Omaima M Sabek, Koen J T Venken, Malgorzata Borowiak

Faculty, Staff and Students Publications

In vitro derivation of pancreatic β-cells from human pluripotent stem cells holds promise as diabetes treatment. Despite recent progress, efforts to generate physiologically competent β-cells are still hindered by incomplete understanding of the microenvironment's role in β-cell development and maturation. Here, we analyze the human mesenchymal and endothelial primary cells from weeks 9-20 fetal pancreas and identify a time point-specific microenvironment that permits β-cell differentiation. Further, we uncover unique factors that guide in vitro development of endocrine progenitors, with WNT5A markedly improving human β-cell differentiation. WNT5A initially acts through the non-canonical (JNK/c-JUN) WNT signaling and cooperates with Gremlin1 to inhibit …

Variability Of Care And Access To Transplantation For Children With Biliary Atresia Who Need A Liver Replacement, Jean De Ville De Goyet, Toni Illhardt, Christophe Chardot, Peace N Dike, Ulrich Baumann, Katherine Brandt, Barbara E Wildhaber, Mikko Pakarinen, Fabrizio Di Francesco, Ekkehard Sturm, Marianna Cornet, Caroline Lemoine, Eva Doreen Pfister, Ana M Calinescu, Maria Hukkinen, Sanjiv Harpavat, Fabio Tuzzolino, Riccardo Superina

Faculty, Staff and Students Publications

Background & Aims: Biliary atresia (BA) is the commonest single etiology indication for liver replacement in children. As timely access to liver transplantation (LT) remains challenging for small BA children (with prolonged waiting time being associated with clinical deterioration leading to both preventable pre- and post-transplant morbidity and mortality), the care pathway of BA children in need of LT was analyzed—from diagnosis to LT—with particular attention to referral patterns, timing of referral, waiting list dynamics and need for medical assistance before LT. Methods: International multicentric retrospective study. Intent-to-transplant study analyzing BA children who had indication for LT early in life …

Implementation Of A Genome-Wide Survey Of Induced Mutations To Identify Agronomically Valuable Variants In Chenopodium Quinoa, Andrew Alarcon Parker

Theses and Dissertations

Quinoa has been utilized for millennia in the Andes region of South America as a nutritious and hardy food crop. In recent years interest in quinoa has grown as need increases for an alternative to traditional cereal crops that can tolerate marginal environments while offering superior nutrition. Growers outside the Andes have experienced several complications adopting quinoa, including undesirable secondary metabolites, poor yield, lodging, and height inconsistency. Unfortunately, access to native ecotypes for crop improvement is limited, and desirable traits are difficult to introduce into available quinoa cultivars because of its allotetraploid genome and tendency to self-pollinate. A genome-wide survey …

The Interplay Between Hydrogen Sulfide And Phytohormone Signaling Pathways Under Challenging Environments, Muhammad Saad Shoaib Khan, Faisal Islam, Yajin Ye, Matthew Ashline, Daowen Wang, Biying Zhao, Zheng Qing Fu, Jian Chen

Faculty Publications

Hydrogen sulfide (H₂S) serves as an important gaseous signaling molecule that is involved in intra- and intercellular signal transduction in plant–environment interactions. In plants, H₂S is formed in sulfate/cysteine reduction pathways. The activation of endogenous H₂S and its exogenous application has been found to be highly effective in ameliorating a wide variety of stress conditions in plants. The H₂S interferes with the cellular redox regulatory network and prevents the degradation of proteins from oxidative stress via post-translational modifications (PTMs). H₂S-mediated persulfidation allows the rapid response of proteins in signaling networks …

The Connection Between Body Modification And Personality, Taylor Shoemaker

Steeplechase: An ORCA Student Journal

Previous research has been inconsistent in its findings regarding the associations between body modifications (e.g., piercings, tattoos, augmentation, scarification, split tongue) and the Big Five personality traits (i.e., openness to experience, conscientiousness, extraversion, agreeableness, neuroticism). All traits have been found to be significantly correlated with body modification in at least one study, but their significance differed from study to study. The purpose of the current study was to examine the associations between body modification and each domain of personality concurrently to add to the literature surrounding differences between modified and unmodified individuals. To participate in this study, participants were asked …

Inhibiting Nitroso Related Methylation Of Guanine Using Dietary Supplements And Flavonoids, Hannah Klose, Madeline Mccoy, Mary Hall

Liberty University Research Week

Undergraduate

Basic

Electrolyte Abnormalities Associated With The Use Of Atezolizumab – A Systematic Review, Abdul Rafae, Sundas Ali, Muhammad Khawar Sana, Farhan Khalid Rana, Ahmed Ibrahim, Zahoor Ahmed, Ali Jan, Hamid Ehsan, Tehreem Fatima, Arvind Kunadi

Journal of Community Hospital Internal Medicine Perspectives

ABSTRACT Background and Objectives: In recent years, immune-checkpoint inhibitors (ICIs) particularly atezolizumab is on the rise in treating advanced malignancies. With its increased clinical use, various electrolyte abnormalities have been reported in the literature. In this review, we have addressed the question of significant electrolyte abnormalities associated with atezolizumab. Materials and Methods: Following PRISMA guidelines, we performed a thorough literature search in four databases including PubMed, Cochrane Library, Embase, and Clinicaltrials.gov. We included only randomized controlled trials from 2010 till March 2021. After a comprehensive screening of 1587 articles, we selected 14 articles for our review and tabulated the results. …

Limits Of Detection Of Mycotoxins By Laminar Flow Strips: A Review, Xinyi Zhao, Hugh Byrne, Christine M. O’Connor, James Curtin, Furong Tian

Articles

Mycotoxins are secondary metabolic products of fungi. They are poisonous, carcinogenic, and mutagenic in nature and pose a serious health threat to both humans and animals, causing severe illnesses and even death. Rapid, simple and low-cost methods of detection of mycotoxins are of immense importance and in great demand in the food and beverage industry, as well as in agriculture and environmental monitoring, and, for this purpose, lateral flow immunochromatographic strips (ICSTs) have been widely used in food safety and environmental monitoring. The literature to date describing the development of ICSTs for the detection of different types of mycotoxins using …

The Academic Work-Life Balance Of Entry-Level Athletic Training Students And Its Implications, Grant Pheil

School of Health and Human Performance Theses

Athletic training students (ATS) have been documented to experience stressors and perceive burnout up to this point in their assimilation into the profession. This is understood through recent work-life balance (WLB) and burnout research within the student population, stemming off research recommendations surrounding the professional setting. However, following current educational shifts and worldwide events, prior research is limited surrounding specific graduate level ATS WLB, stressors, coping responses, and comparisons across ATS demographics. The purpose of this study is to identify this balance in graduate level students and highlight stressors or management techniques that will benefit future students pursuing athletic training …

Eating Healthy Does Not Have To Break The Bank, Adam Pope

Browse All News

No abstract provided.

Nutrient Transporter Gene Expression In The Early Conceptus—Implications From Two Mouse Models Of Diabetic Pregnancy, Claudia Kappen, Claudia Kruger, Sydney Jones, J. Michael Salbaum

Division of Basic Science Faculty Publications

Maternal diabetes in early pregnancy increases the risk for birth defects in the offspring, particularly heart, and neural tube defects. While elevated glucose levels are characteristic for diabetic pregnancies, these are also accompanied by hyperlipidemia, indicating altered nutrient availability. We therefore investigated whether changes in the expression of nutrient transporters at the conception site or in the early post-implantation embryo could account for increased birth defect incidence at later developmental stages. Focusing on glucose and fatty acid transporters, we measured their expression by RT-PCR in the spontaneously diabetic non-obese mouse strain NOD, and in pregnant FVB/N mouse strain dams with …

Assessment Of Antifungal Efficacy Of Itraconazole Loaded Aspasomal Cream: Comparative Clinical Study, Dalia Attia, Caroline Lamie, Enas Elmowafy, Maha Ragaie, Nahed Mortada

Pharmacy

Topical conveyance of antifungal agents like itraconazole ITZ has been giving good grounds for expecting felicitous antifungal medicines. The defiance of topical delivery of this poorly water soluble and high-molecular-weight drug, however, mightily entail an adequate vehiculation. ITZ aspasomes, newer antioxidant generation of liposomes, have been designed and enclosed in a cream to ameliorate skin deposition. The proposed creams containing non-formulated ITZ or encapsulated in aspasomes (0.1% or 0.5%) were topically applied in patients with diagnosed diaper dermatitis complicated by candidiasis, tinea corporis (TC), and tinea versicolor (TVC). Placebos (void aspasomal cream and cream base) were also utilized. The obtained …

Inspire Student Research & Engagement Conference [Program] April 11-12, 2022, University Of Northern Iowa

INSPIRE Student Research & Engagement Conference Programs

A program for the INSPIRE conference where undergraduate and graduate students present their research, internship, volunteer and study abroad experiences, club activities and creative performances.

Sex-Specific Differences In Microrna Expression During Human Fetal Lung Development., Nancy W. Lin, Cuining Liu, Ivana V. Yang, Lisa A. Maier, Dawn L. Demeo, Cheyret Wood, Shuyu Ye, Margaret H. Cruse, Vong L. Smith, Carrie A. Vyhlidal, Katerina Kechris, Sunita Sharma

Manuscripts, Articles, Book Chapters and Other Papers

Background: Sex-specific differences in fetal lung maturation have been well described; however, little is known about the sex-specific differences in microRNA (miRNA) expression during human fetal lung development. Interestingly, many adult chronic lung diseases also demonstrate sex-specific differences in prevalence. The developmental origins of health and disease hypothesis suggests that these sex-specific differences in fetal lung development may influence disease susceptibility later in life. In this study, we performed miRNA sequencing on human fetal lung tissue samples to investigate differential expression of miRNAs between males and females in the pseudoglandular stage of lung development. We hypothesized that differences in miRNA …

Diel Gene Expression Improves Software Prediction Of Cyanobacterial Operons, Philip Heller

Faculty Research, Scholarly, and Creative Activity

Cyanobacteria are important participants in global biogeochemical process, but their metabolic processes and genomic functions are incompletely understood. In particular, operon structure, which can provide valuable metabolic and genomic insight, is difficult to determine experimentally, and algorithmic operon predictions probably underestimate actual operon extent. A software method is presented for enhancing current operon predictions by incorporating information from whole-genome time-series expression studies, using a Machine Learning classifier. Results are presented for the marine cyanobacterium Crocosphaera watsonii. A total of 15 operon enhancements are proposed. The source code is publicly available.

Sex Ratios And The City: Is Parental Corticosterone A Mediator Of The Relationship Between Urbanization And Offspring Sex Allocation?, Denyelle Kilgour

Master of Science in Integrative Biology Theses

The Trivers-Willard hypothesis states that mothers can adjust their offspring sex ratios according to their own condition and the environmental conditions they face during breeding. Past tests of this hypothesis in avian species have focused on how natural variation shapes sex allocation trade-offs. However, urbanization also influences individual condition and presents animals with novel challenges in optimizing their brood sex ratio. One likely mediator of the relationship between environmental conditions, parental condition, and sex ratios is corticosterone (CORT), the primary glucocorticoid in birds. However, no research has examined the links between urbanization, individual condition, CORT, and adaptive sex allocation within …

“Many People Have No Idea”: A Qualitative Analysis Of Healthcare Barriers Among Yazidi Refugees In The Midwestern United States, Falah Rashoka, Megan S. Kelley, Jeong‑Kyun Choi, Marc A. Garcia, Weiwen Chai, Hazim N. Rashawka

Department of Nutrition and Health Sciences: Faculty Publications

Background: The COVID-19 pandemic has shed new light on inequities in healthcare access faced by immigrant and refugee communities. To address ongoing disparities, there is an urgent need for ecological approaches to better understand the barriers that hinder and resources that facilitate access to healthcare. This study investigates barriers to healthcare system access faced by Yazidi refugees in the Midwestern United States.

Methods: Informed by the Interpretative Phenomenological Approach, three focus group meetings with a community advisory board were conducted between September 2019 and January 2020. The nine-member focus group included social workers, healthcare providers, and members of …

Temporal Variation Of Bacterial Community And Nutrients In Tibetan Glacier Snowpack, Yuying Chen, Keshao Liu, Yongqin Liu, Trista J. Vick‐Majors, Feng Wang, Mukan Ji

Michigan Tech Publications, Part 1

The Tibetan Plateau harbors the largest number of glaciers outside the polar regions, which are the source of several major rivers in Asia. These glaciers are also major sources of nutrients for downstream ecosystems, while there is a little amount of data available on the nutrient transformation processes on the glacier surface. Here, we monitored the carbon and nitrogen concentration changes in a snowpit following a snowfall in the Dunde Glacier of the Tibetan Plateau. The association of carbon and nitrogen changes with bacterial community dynamics was investigated in the surface and subsurface snow (depth at 0–15 and 15–30 cm, …

Breastfeeding Intention And Initiation Among Rural, Low-Income Native Americans And African American Adolescent Mothers In North Carolina: Testing The Theory Of Planned Behavior, Cynthia H. Herndon

Dissertations

Infant feeding practices can greatly impact a child's life with far reaching implications based upon decisions a mother makes for her newborn. Breastfeeding is the preferred method of infant feeding because of its association with health benefits to both the mother and child. The prevalence of breastfeeding among rural, low income, disadvantaged groups to include Native American (NA) and African American (AA) adolescent mothers is low. NAs and AAs bear a disproportionate burden of illness and health risks compared to other races and ethnic groups in the United States. Breastfeeding is a targeted public health strategy to improve the health …

Ngss-Based Constructivist Pedagogies: One Secondary Education Teacher’S Approach To Developing Student’S Science Identities, Massa Mafi

Teacher Education, Educational Leadership & Policy ETDs

This practitioner action research study explored features of NGSS-based pedagogies to improve secondary education student engagement, critical thinking, and collaborative problem-solving. It examined ways that constructivist pedagogies might encourage students to understand science by putting their skills and knowledge into practice as young engineers. The study involved 51 secondary education students from a large district in the southwest and focused on how NGSS inquiry-based learning can improve scientific understanding and skills within group work, the role that teacher support and modeling can play in learning, and how peer interactions can influence their scientific identities. Qualitative findings from teacher observations, classwork …

Bismuth Nanoparticle And Polyhydroxybutyrate Coatings Enhance The Radiopacity Of Absorbable Inferior Vena Cava Filters For Fluoroscopy-Guided Placement And Longitudinal Computed Tomography Monitoring In Pigs, Jossana A Damasco, Steven Y Huang, Joy Vanessa D Perez, John Andrew T Manongdo, Katherine A Dixon, Malea L Williams, Megan C Jacobsen, Roland Barbosa, Gino Martin Canlas, Gouthami Chintalapani, Adam D Melancon, Rick R Layman, Natalie W Fowlkes, Elizabeth M Whitley, Marites P Melancon

Faculty, Staff and Student Publications

Inferior vena cava filters (IVCFs) constructed with poly-

A Nematode Community-Based Integrated Productivity Efficiency (Ipe) Model That Identifies Sustainable Soil Health Outcomes: A Case Of Compost Application In Carrot Production, A. Habteweld, A. Kravchencko, Parwinder Grewal, H. Melakeberhan

School of Earth, Environmental, & Marine Sciences Faculty Publications

Percent soil organic matter (SOM), pH and crop yield are among the biophysicochemical process-driven soil health indicators (SHIs). However, identifying sustainable soil health conditions using these SHIs is limited due to the lack of Integrated Productivity Efficiency (IPE) models. We define IPE as a concept that identifies best-to-worst-case soil health outcomes by assessing the effect of agronomic practices on weighted abundance of functional guilds (WAFG) of beneficial soil organisms and SHIs simultaneously. Expressing WAFG of all beneficial nematodes (x-axis) and SHIs (y-axis) as a percent of untreated control and regression of x and y reveals four quadrants describing worst-to-best-case outcomes …

Temporal Variation Of Bacterial Community And Nutrients In Tibetan Glacier Snowpack, Yuying Chen, Keshao Liu, Yongqin Liu, Trista J. Vick‐Majors, Feng Wang, Mukan Ji

Michigan Tech Publications, Part 1

The Tibetan Plateau harbors the largest number of glaciers outside the polar regions, which are the source of several major rivers in Asia. These glaciers are also major sources of nutrients for downstream ecosystems, while there is a little amount of data available on the nutrient transformation processes on the glacier surface. Here, we monitored the carbon and nitrogen concentration changes in a snowpit following a snowfall in the Dunde Glacier of the Tibetan Plateau. The association of carbon and nitrogen changes with bacterial community dynamics was investigated in the surface and subsurface snow (depth at 0-15 and 15-30 cm, …

Mood Responses To Various Exercise Types Using The Ontological Definitions Of Exercise, Nathalie Barrios, Sucharitha Dodamgodage, Olaoluwa Ogunleye, Madushi Wickramasinghe, Sumona Mondal, Andreas Stamatis, Ali Boolani

International Journal of Exercise Science: Conference Proceedings

Recently, a new ontological way of exploring sport and physical activity (PA) has been proposed: the type of PA performed is classified using the four ontological dimensions. This phenomenon has classified PA as individual (I-me), encounter (I-You), team (I-Society), and nature (I-Nature). There has only been one study that has examined how participating in these various types of PA influences moods; however, that study asked individuals to recall what types of PA were performed and how they felt more than 60 days before the commencement of the study. PURPOSE: To identify whether daily moods differ based on the four …

Strength Versus Deficit Educational-Based Interventions On Mental Toughness: A Case Study Of Female Student-Athletes, Lindsay Guzzetta, Grant Morgan, Zacharias Papadakis, Andreas Stamatis

International Journal of Exercise Science: Conference Proceedings

Educational-based psychological skills training (PST) is effective in terms of Positive Psychology outcomes. Mental toughness (MT), a Positive Psychology construct, is positively associated with sports performance via mostly correlational research. Sports training emphasizes working on the weaknesses of the athlete. Positive Psychology is rooted in strength-based interventions. In Applied Sports Positive Psychology, where females are underrepresented, the two approaches appear contradictory. PURPOSE: To examine the effects of deficit- versus strength-based interventions on MT levels of female collegiate athletes. METHODS: Out of 161 female SUNY Plattsburgh athletes, 95 participated. MT scores were collected via the eight-item, Mental Toughness Index …

Position Profiles Based On Gps Metrics: A Ncaa Division Iii Men's Soccer Case Study, Luke Rapaport, Hiroki Matsuo, Grant Morgan, Andreas Stamatis

International Journal of Exercise Science: Conference Proceedings

According to the ACSM, wearable technology is the number one fitness trend for 2022. Division III schools are the biggest participant in the NCAA. In terms of the number of student-athletes, soccer is the second most popular sport in the NCAA. This is a continuation of research whose initial findings were presented by Lecher et al. (2022) in the 2022 Annual TACSM Annual Meeting and published by the International Journal of Exercise Science. PURPOSE: To analyze and interpret the game data from 2020-21 season to answer the head coach’s additional questions of a) What is the profile per position …

Grit Had A Positive Impact On Moderate-To-High Intensity Physical Activity During The Covid-19 Health Crisis, Kyle Pellerin, Thomas Parrillo, Grant Morgan, Joel Martin, Shane V. Caswell, Nelson Cortes, Ali Boolani, Andreas Stamatis

International Journal of Exercise Science: Conference Proceedings

Recently, moderate-to-vigorous intensity physical activity (MVPA) has attracted additional scientific interest (e.g., ACSM recommendations) not only thanks to a) the physical and psychological benefits that can be experienced by the general population following just a single bout, but also b) since high levels of MVPA seem to mitigate the mortality risk associated with high levels of sedentary behavior, such as sitting. Non-pharmaceutical interventions against the COVID-19 (e.g., stay-at-home orders) have altered people’s lifestyles (e.g., physical activity, sitting time). Grit, a higher-order personality trait based on two lower-order components (i.e., perseverance and consistency), is highly predictive of both success and performance. …

Predicting In-Season Performance From Pre-Season Power And Gait Metrics In Collegiate Basketball: Preliminary Evidence, Jasmine Piper, Bill Siddiq, Hiroki Matsuo, Grant Morgan, Ali Boolani, Andreas Stamatis

International Journal of Exercise Science: Conference Proceedings

Power training affects gait patterns. Power training also affects basketball performance. The Efficiency index (EFF) is the most used in-season basketball performance metric in the US. Strength and conditioning coaches measure power output via specific jumping tests. Could the pre-season relationship between power and gait provide additional information in foreseeing performance before the basketball season starts? PURPOSE: To a) confirm that pre-season standing broad jump (SBJ) scores correlate with post-season EFF and b) explore if pre-season SBJ scores and pre-season gait metrics (Jumping Point Gap Broad Jump, Stride, and Speed) are correlated. METHODS: Participants (n=17) were recruited from …

Suicide Prevention In Bangladesh: The Role Of Family, S M Yasir Arafat, Tamkeen Saleem, Todd M. Edwards, Syeda Ayat-E-Zainab Ali, Murad M. Khan

Department of Psychiatry

Background: Suicide is a public health problem that gets little attention in Bangladesh especially in prevention aspects. Recent studies revealed that a significant portion of risk factors is closely related to family events. However, potential prevention strategies considering the family structure and involving family dynamics of Bangladesh have not been discussed.
Objectives: We aim to highlight areas of family vulnerability and resilience when the threat of suicide is present, as well as the potential roles of family in suicide prevention in Bangladesh.
Methods: We conducted a thorough narrative and focused literature search and synthesized evidence based on available articles discussing …

Pemilihan Teknik Aplikasi Dan Dosis Pupuk Hayati Pelarut Kalium Untuk Meningkatkan Serapan Kalium Dan Pertumbuhan Tanaman Jagung Pada Tanah Inceptisols, Diyan Herdiyantoro, Tualar Simarmata, Mieke Rochimi Setiawati, Nenny Nurlaeny, Benny Joy, Mahfud Arifin, Jajang Sauman Hamdani, Iin Handayani

Jurnal Kultivasi

Salah satu strategi yang diterapkan pada pupuk hayati untuk menunjukkan efek positif pada tanaman yang diinokulasi adalah pemilihan teknik aplikasi dan dosis yang tepat, baik pada tanah, benih, atau kombinasi keduanya. Tujuan dari percobaan ini adalah mendapatkan teknik aplikasi dan dosis pupuk hayati pelarut K yang memberikan hasil terbaik terhadap penyerapan K dan pertumbuhan tanaman jagung (Zea mays L.) pada Inceptisols Jatinangor. Percobaan dilaksanakan pada November 2018-Januari 2019 di rumah kaca Fakultas Pertanian Universitas Padjadjaran. Percobaan menggunakan rancangan acak kelompok dengan 9 perlakuan dan 3 kali ulangan. Perlakuan terdiri dari tanpa perlakuan (kontrol), aplikasi pada benih 400 g.ha-1 dan 800 …