Digital Commons Network^™

Improving Care And Licensing Standards And Oversight In America's Zoos, Hannah Willis

Honors Theses

Since 1966, the Animal Welfare Act has been the official federal legislation passed to provide care standards and regulations for publicly exhibited animals, specifically exotic animals within zoos; however, in an age of major advocacy for improved animal welfare standards for all animals, the AWA has remained fairly stagnant in its guidelines for animal exhibitors. Through numerous articles, documentaries, and TV shows, specific zoos and animal exhibitors have shown many Americans that there seems to be little to no governmental oversight over zoos that have engaged in poor animal care or those engaging in often dangerous and cruel animal contact …

Assessment Of Motivation In Human Anatomy And Physiology Students, Mary Whitehead

Honors Theses

Motivation is the key to success in difficult science courses such as Human Anatomy and Physiology. Students may possess intrinsic motivation, or motivation for enjoyment, extrinsic motivation, or motivation for a reward, or amotivation, a lack of motivation at all. The goal of this experiment was to identify better ways of helping students succeed in Human Anatomy and Physiology (HAP) at the University of Mississippi, determine when motivational efforts seem to decrease during the semester, and identify how to better develop intrinsic motivation in students. There was a significant relationship between many of the student’s survey responses to their exam …

A Study Of Dextran As A Macromolecular Crowding Agent, Katherine Morgan

Honors Theses

Deoxyribonucleic acid (DNA) is the hereditary material in all living organisms. According to the Watson and Crick model, DNA exists as two long strands coiled into a double helix. However, DNA has been found to have the potential to exist in secondary forms known as G-Quadruplexes and i-motifs. I-motifs (intercalated-motif or iM) are formed under acidic conditions when sets of cytosines pair with protonated cytosines and are looped around each other. The pKa value for iMs in dilute solutions is approximately 6.5, but iMs can potentially exist at a higher, physiological pH value under crowded conditions. Within the interior of …

Family History, Cultural Custom, And Personal Preference: The Accents Of Food Access In Oxford, Mississippi, James Hirsch

Honors Theses

Contemporary food access literature in the social sciences centers on models of food decisions emphasizing income, prices, distance, and time. To challenge this analysis, this research conducts interviews with six residents of Oxford, Mississippi, focused on their food habits. These interviews have been summarized, and motivating factors have been extracted and compared back to the literature’s findings. The motivating factors found through the interviews include perceived differences in food quality, store opening/closing hours, partner/family preferences, family/cultural influences, and perceived risks from the COVID-19 pandemic. In contrast to the literature, spaciotemporal concerns were less dominating among participants than the above factors, …

Market Pressure Based On International Food Standards In Export-Scale Urban Farming: Political Ecology Perspective, Kinanti Indah Safitri, Oekan Soekotjo Abdoellah, Budhi Gunawan, Yusep Suparman, Parikesit Parikesit

The Qualitative Report

Urban farming has been transformed into urban agricultural activities oriented towards optimizing economic benefits through export market involvement. However, the expansion of the market has consequences for farmers. The involvement of urban farmers in export trade causes market pressures that affect agricultural production practices. This research used qualitative research methods. There were 27 informants in this study. Researchers collected data to determine market pressures faced by export-scale urban farmers in Bandung Metropolitan. Data collection techniques used in-depth interviews, observation, and documentation. The results showed that the market had put pressure on export-scale urban farmers in Bandung Metropolitan to meet international …

Barriers To Breastfeeding For Mothers In The Mississippi Women, Infants, And Children Program: Insights Of Peer Counselors, Grace Louise Dragna

Honors Theses

Breastfeeding has been recognized by numerous public health organizations as the optimal feeding practice for infant growth and development, yet the state of Mississippi has one of the lowest breastfeeding rates in the nation. The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) program in Mississippi offers breastfeeding resources to low-income women throughout the state. Mothers enrolled in WIC can receive peer counseling services from women in their community who have personal experience with breastfeeding. This study serves to identify WIC peer counselors’ perceptions of factors influencing Mississippi WIC participants’ decisions to initiate and sustain breastfeeding. I interviewed …

A Systematic Review Of Music Therapy For Children With Autism Spectrum Disorder, Alana Andrus

Honors Theses

Music therapy has been suggested to be effective in Autism. The purpose of this systematic review was to assess the effectiveness of music therapy as a potential treatment option for individuals with autism spectrum disorder, or ASD. To obtain published records, a PubMed search was conducted with the search term “music therapy autism,” which generated 187 studies. Each study was evaluated for relativity to the topic at hand. The remaining 151 articles were assessed for support status, as well as other later suggested research, in order to more confidently support music therapy as a treatment option for ASD patients. Approximately …

Trends In Prenatal Care Accessibility In Rural Mississippi And How These Trends Affect Unfavorable Birth Outcomes, Maura Isabella Webb

Honors Theses

This thesis investigated the level of accessibility to prenatal care in rural Mississippi areas and how this affects or has affected Mississippi’s high rates of unfavorable birth outcomes. The research questions included specifically looked at how lack of prenatal care in rural areas of Mississippi plays a role, if any, in extremely high rates of unfavorable birth outcomes as well as what policy can be implemented to expand education regarding unfavorable birth outcomes. To understand the effects of accessibility and eligibility of rural women’s health care, seven women were interviewed. Interviews were conducted with these women who met the criteria …

An Exploratory Look Into The Effects Of Mississippi's Population Decline On Rural Dental Care, Allen Bailey Saffold

Honors Theses

Literature reviews and interviews with dentists working in rural Mississippi counties examined the effects of population decline on rural dental care in Mississippi. With the state’s continual population decline, loss of industry follows a loss of people. Through a cascade of effects, this can further reduce underserved areas’ access to dental care. In order to address the issue of rural Mississippi continuing to be underserved, policies need to be implemented that will make rural practice at least enticing if not desirable.

Developing A Novel Place Preference Assay To Compare Drosophila Species Over Time, Martha M. Brinson

Honors Theses

Across phylogeny, integration of external factors, memory, and internal states of the organism dictate organismal behavior and mechanisms. The underlying genetic components can affect these behaviors such as in genomic changes arising from speciation. In this thesis, a new place preference assay was evaluated in the analysis and investigation of two species of Drosophila flies (D. melanogaster and D. simulans) to measure similarities and differences and their attraction to two different food substrates. Sleep and circadian measurements were also recorded during experimentation. The Drosophila Activity Monitor 5M (DAM5M) System and Sleep Circadian Analysis MATLAB Program (SCAMP) analysis were …

Retro-Structural Analysis Of The Four Helix Bundle Motif In Binuclear Proteins, Walker Pedigo, Maggie Smith

Honors Theses

Protein structure is directly related to protein function. There are four levels of protein structure: primary, secondary, tertiary, and quaternary. The interactions amongst the structural components of a protein give rise to its unique characteristics. The four helix bundle motif is a common structural trait in a variety of binuclear proteins. In this study, PyMOL, a molecular visualization system, was used to analyze binuclear proteins that possess a four helix bundle. Images of proteins containing dicopper, diiron, and dimanganese sites were captured. The images were compiled into figures for each individual protein. After creating the figures, each protein was further …

South Dakota State University One Hundred Thirty-Sixth Commencement Ceremonies, May 7, 2022, South Dakota State University

Commencement Programs

Please note: The names listed in the program are not official confirmation of meeting the graduation requirements. Commencement for the 136th Commencement at South Dakota State University consists of a morning afternoon, and evening ceremony. Each program will commence with introductions by University President Barry H. Dunn. Dennis D. Hedge, Provost and Vice President for Academic Affairs will acknowledge student honors and Lt. Col. Jason A. Haufschild, Air Force ROTC, recognizing Army and Air Force commissions for each ceremony. The MORNING ceremony (page 7) will mark the conferral of undergraduate and graduate degrees from the College of Agriculture, Food, and …

Nurse Job Satisfaction In The Midst Of A Pandemic, Reynaldo Gonzales

Doctor of Nursing Practice Scholarly Projects

Strategies and intervention for nursing recruitment and retention are critical needs at the hospital unit management level especially during this time of coronavirus disease of 2019 (COVID-19) pandemic.

Research Question: What are the unit-levels of nurse job satisfaction among eight satisfaction dimensions (i.e., satisfaction with extrinsic rewards, scheduling, family/work balance, co-workers, interaction, professional opportunities, praise/recognition, and control/responsibility) in an acute medical-surgical unit?

Objectives The objective of this project is to systematically obtain unit-level input to explore nurses’ views and experiences as it relates to job satisfaction.

Methodology: This is a descriptive cross-sectional convenience study measuring job satisfaction among Registered Nurses …

Cache Like A Squirrel: Effects Of Long Term Storage On Crude Fat Content Of Q. Palustris And Q. Alba Acorns, Cheyenne T. Villarosa, Sabrina Volponi, Timothy A. Kreps, Tamara L. Johnstone-Yellin

Honors Projects

Quercus palustris and Quercus alba acorns are a primary component in many wild animal diets, particularly during preparation for winter. As such, they provide a natural, easily gathered food staple for wildlife recovering in rehabilitation facilities. We examined whether collection and temperature-controlled storage methods differentially affect the nutritional deterioration of crude fat in acorns to assess both caching by wildlife and to provide recommendations to rehabilitators. We collected acorns from Q. palustris in 2020 (N=8) and Q. alba in 2017 (N=11) in Bridgewater, VA, USA. Acorns were dried for 7 days using a fan or for 30 minutes in an …

Comparing Intuitive Eating Behaviors Between Student Athletes And College Students Enrolled At The University Of Mississippi, Mary Mckennon Pierce

Honors Theses

Intuitive eating strives to consciously listen to the internal hunger and fullness cues our body provides, as humans often practiced long before counting calories and dieting existed. Rational thought, instinct, and emotion influence an intuitive eater’s decision-making and allow for full capability in navigating food decisions. While intuitive eating habits can benefit any individual, little research has compared the intuitive eating habits between collegiate students and student-athletes. measures unconditional permission to eat, eating for physical rather than emotional reasons, reliance on hunger and fullness cues, and body-food choice congruence. Student-athletes presented a significantly higher overall intuitive eating score (3.53±0.54, p=0.003) …

Reno-Protective And Immune Effects Of Growth Differentiation Factor 15 In Obesity-Related Kidney Disease, Jessie T. Sullivan

Honors Thesis

According to the World Health Organization, worldwide obesity has tripled since 1975 and is still on the rise, putting people at a higher risk of some cardiovascular diseases and kidney disease. Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine that has been studied recently for its role in multiple biological processes and diseases. The member of the transforming growth factor beta (TGF-b) family has been investigated as a therapeutic agent and biomarker for obesity and associated cardiovascular diseases, stroke, diabetes, osteoarthritis, cancer, and kidney disease. Studies have shown the anti-inflammation, anti-obesity, and anti-diabetic effects of GDF15, but few have …

Food Insecurity Among Niu College Students, Hannah Schaumberg

Student Projects

Many people with certain privileges never notice them, because they are so fixated on the hasty generalizations of what is seen on the surface rather than the interior aspects. For many students, understanding and recognizing privileges is the main concept to understanding their surroundings. The concept of reflecting on their interactions and knowledge of food insecurity will be curasol among communities. By researching the concepts of food insecurities among NIU students, we can bring awareness of the topic within society. The focus is to understand which intersectional groups are affected by food insecurity and to bring awareness of the subject …

Feasibility And Efficacy Of Bisphosphonate Use For The Prevention Of Bone And Muscle Loss, Laura E. Flores

Theses & Dissertations

Loss of bone and muscle mass often occurs in tandem, increasing the risk of fragility fractures. Whereas many drugs are approved for the treatment of bone loss, there are few treatments available for the concomitant loss of bone and muscle. Identification of a treatment to mitigate pathologic bone and muscle atrophy has the potential to impact countless populations and influence approaches for healthy aging. Bisphosphonates have emerged as a potential treatment for both bone and muscle loss in cellular, murine, and observational human studies. Our findings of modest weight maintenance in postmenopausal women treated with 12-months of risedronate, relative to …

Biologically-Inspired Nanoparticles For Oncology Applications, Aishwarya Bapat

Theses & Dissertations

Cancer is the leading cause of death in the United States and its high mortality rate can be attributed towards poor diagnosis methods and less effective therapeutic treatments. Many nanotechnology-based diagnostics and therapeutics are being developed to improve cancer patient outcomes. In this work, we have studied nanoparticles for diagnostic and therapeutic applications in cancer treatment.

In the first work, novel fluorescent NPs loaded with indocyanine green (ICG) were developed for bioimaging applications of pancreatic cancer. Targeted fluorescent nanoparticles (NPs) are being developed to image a range of cancer types with the goal to improve patient outcomes by utilizing in …

The Development Of Thermoresponsive Hydrogel-Based Drug Delivery Systems For The Treatment Of Musculoskeletal Diseases, Ningrong Chen

Theses & Dissertations

Water-soluble polymers are one of the most commonly used drug delivery vehicles for musculoskeletal diseases. During the past few decades, various biocompatible polymers have been employed in the development of thermoresponsive hydrogels as drug delivery systems for the treatment of local musculoskeletal pathologies. As part of our laboratory’s contribution to this field of study, I have successfully developed three thermoresponsive hydrogel-based formulations for the treatment of three different pathologies associated with the musculoskeletal system.

As my initial effort, I have developed a bone-targeting injectable hydrogel drug delivery system based on Pluronic 127 (Poloxamer 407), which is a Generally Recognized As …

Visceral Adipose Tissue Remodeling In Pancreatic Ductal Adenocarcinoma Cachexia: The Role Of Activin A Signaling, Pauline Xu

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer death in the United States and is projected to become the second leading cause by the year 2030. Prognosis for patients with metastatic disease remains dismal, with cachexia as a main contributor to the low survival rate. Emerging reports indicate that PDAC patients display distinct phenotypes of cachexia development, with either adipose tissue loss preceding skeletal muscle wasting or loss of only adipose tissue. While muscle wasting has been the most frequently studied mechanism in cachexia research, changes in adipose tissue are increasingly understood as important components of …

Modulating Cellular Senescence To Improve Age-Associated Wound Healing Impairment, Upasana Niyogi

Theses & Dissertations

Impaired tissue repair and regenerative ability in the aged is a major socio-economic and clinical problem. One of the likely factors associated with poor wound healing is the presence of lingering senescent cells in the wound sites. Failure to eliminate these cells has been associated with inadequate healing, excessive scarring, and abnormal skin stiffening. Thus, the objective of our study was to test interventional strategies to mitigate the negative effect of senescent cells. We hypothesized that reducing senescent cell burden and promoting non-senescent cell functionality will improve wound healing with age.

We developed a 3D in vitro senescent fibroblast populated …

Evaluation Of Awareness, Knowledge, And Preventive Intervention Of Nonalcoholic Fatty Liver Disease Among Chinese Young Adults, Yi Du

Theses & Dissertations

The prevalence of nonalcoholic fatty liver disease (NAFLD) among Chinese young adults (CYA) aged 18-25 years ranges from 4.7% to 15.1% and has kept increasing in recent years. Previous studies reported limited awareness and knowledge of NALFD among middle-aged and older Chinese populations, however, they have not investigated awareness in CYA, for which there is no well-validated questionnaire. There is currently no efficacious educational intervention on NAFLD for CYA.

The objectives were 1) to develop and validate a questionnaire which can be used to assess the awareness and knowledge of NAFLD among CYA; 2) to assess the awareness and knowledge …

Tourniquet-Induced Ischemia-Reperfusion Injury, Junliang Qian

Theses & Dissertations

Ischemia-reperfusion (IR) is a pathological condition characterized by an initial restriction of blood supply to an organ followed by subsequent restoration of reperfusion associated with exacerbation of tissue damage. For pre-hospital emergency situations and surgical procedures, tourniquet or femoral artery ligation are widely used to stop extremity hemorrhage or create a bloodless operating field. To fully evaluate the underlying mechanisms in IR pathophysiology and potential therapeutic options, we compared tourniquet- and femoral artery ligation-induced IR injuries in the hindlimb of mice. We found that tourniquet/IR-induced acute hindlimb injuries are more severe than those induced by femoral artery ligation/IR, including alteration …

Investigation Of Cumulative Genetic Risk And Cc16 In Adult Asthma And Copd Populations, Kelli C. Gribben

Theses & Dissertations

INVESTIGATION OF CUMULATIVE GENETIC RISK AND CC16 IN ADULT ASTHMA AND COPD POPULATIONS

Kelli C. Gribben, Ph.D.

University of Nebraska Medical Center, 2022

Supervisors: Paraskevi A. Farazi and Tricia D. LeVan, Ph.D.

Asthma and Chronic Obstructive Pulmonary Disease (COPD) have complex etiologies and lack biological predictors that can be used for primary prevention, early detection, progression, or monitoring. Genetic risk scores (GRS) aggregate genetic effects from GWAS-identified susceptibility variants associated with a trait. GRS may provide opportunities to improve disease prediction to inform public health and clinical interventions. Asthma GRS studies utilizing multi-ethnic populations are scarce and there is a …

Polymeric Nanocarriers For Delivery Of Small Molecules Inhibiting Tubulin Polymerization For The Treatment Of Pancreatic Cancer And Lung Metastatic Melanoma, Rajan Sharma Bhattarai

Theses & Dissertations

The aim of this thesis is to develop delivery systems for the novel small molecules which inhibit tubulin polymerization. One of the small molecules was modified to lipid conjugate to increase the lipophilicity of the molecules which in turn drastically improved the drug loading in amphiphilic polymeric system. The second molecule was conjugated to the amphiphilic polymeric backbone with pH sensitive Schiff’s linker for the tumor site specific delivery in lung metastatic melanoma model.

Chapter 1 discusses the tumor microenvironment for the solid tumor especially focusing on Pancreatic Ductal Adenocarcinoma (PDAC). Further the drug delivery system currently researched for addressing …

Regulation Of Pancreatic Cancer Progression By Micronutrients, Chunbo He

Theses & Dissertations

Cancer cells rely on altered metabolism to support their uncontrolled proliferation under harsh conditions. Understanding the mechanisms of how metabolic alterations support tumor growth may provide a way to enhance current therapies. Vitamins are micronutrients that our body needs in small quantities but are essential for health maintenance. A number of metabolic processes relevant to cancer initiation and progression are also regulated by vitamins. Here, our studies showed that pancreatic ductal adenocarcinoma (PDAC) cells display an aberrant metabolism of vitamin B6 (VB6) to support their fast proliferation. VB6 was highly demanded and rapidly metabolized by PDAC cells. Depletion of VB6 …

Body Image Perceptions Reflected In Social Media: A Guatemalan Instagram Study, Sarah Harris

Honors Theses

Guatemala has faced a long battle with colonialism, civil war, and an ensuing, rapid urbanization. Still today, the country exhibits high levels of malnourishment while also facing an ascending obesity epidemic. This project seeks to explore how the obesity epidemic has changed body image perceptions in the region. Through the use of social media accounts on Instagram, I aim to analyze how Guatemalan influencers use their platform to explore notions of varying body image perceptions in a country where food is culturally significant, malnutrition has plagued many communities, and obesity is growing in prevalence daily. This thesis aims to answer …

An Exploration Of Physical Education Teachers’ Perceptions Of And Experiences With Body Image, Natallie Noel

Honors Theses

Adolescents experience a broad range of physical and emotional changes and begin looking to peers and social media to determine what their bodies should look like through the lens of society. This process of adolescents beginning to visualize themselves is known as body image. These include physical competence, motivation, self-esteem, and confidence through the way the teachers interact with students, develop positive learning spaces, and develop and implement intentional instruction and programs, thus, providing a space where adolescents begin to develop a healthy perception of their own body (Kerner et al., 2017). However, the breadth of literature on body image, …

Assessment Of Spatial Skills In Human Anatomy And Physiology Students, Abigail Carroll

Honors Theses

Visual spatial skills are an individual’s ability to mentally and manipulate the shapes, forms and positions of objects. Spatial skills are necessary for adequate learning in many settings. Few studies have assessed spatial skills compared to success in Anatomy and Physiology in undergraduate students. Most students in this course are on a health profession track. Due to the increasing health care demands and need for competent health care professionals, this study assesses the innate spatial skill ability in students and acquired additional learned spatial skills. This study tests 17 students with the paper-folding test, blank page test, and two surveys …