Digital Commons Network^™

The 5th Edition Of The World Health Organization Classification Of Haematolymphoid Tumours: Myeloid And Histiocytic/Dendritic Neoplasms, Joseph D Khoury, Eric Solary, Oussama Abla, Yassmine Akkari, Rita Alaggio, Jane F Apperley, Rafael Bejar, Emilio Berti, Lambert Busque, John K C Chan, Weina Chen, Xueyan Chen, Wee-Joo Chng, John K Choi, Isabel Colmenero, Sarah E Coupland, Nicholas C P Cross, Daphne De Jong, M Tarek Elghetany, Emiko Takahashi, Jean-Francois Emile, Judith Ferry, Linda Fogelstrand, Michaela Fontenay, Ulrich Germing, Sumeet Gujral, Torsten Haferlach, Claire Harrison, Jennelle C Hodge, Shimin Hu, Joop H Jansen, Rashmi Kanagal-Shamanna, Hagop M Kantarjian, Christian P Kratz, Xiao-Qiu Li, Megan S Lim, Keith Loeb, Sanam Loghavi, Andrea Marcogliese, Soheil Meshinchi, Phillip Michaels, Kikkeri N Naresh, Yasodha Natkunam, Reza Nejati, German Ott, Eric Padron, Keyur P Patel, Nikhil Patkar, Jennifer Picarsic, Uwe Platzbecker, Irene Roberts, Anna Schuh, William Sewell, Reiner Siebert, Prashant Tembhare, Jeffrey Tyner, Srdan Verstovsek, Wei Wang, Brent Wood, Wenbin Xiao, Cecilia Yeung, Andreas Hochhaus

Faculty, Staff and Students Publications

The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought …

United States Healthcare Burden Of Pediatric Functional Gastrointestinal Pain Disorder Hospitalizations From 2002 To 2018, John M Hollier, Jason L Salemi, Robert J Shulman

Faculty, Staff and Students Publications

BACKGROUND: The healthcare burden of pediatric functional gastrointestinal pain disorders (FGIDs) is unclear. Our study aimed to characterize the burden of these hospitalizations in the United States (US).

METHODS: We utilized the US National Inpatient Sample from 2002 to 2018 to capture pediatric hospitalizations (ages 4 to 18 years old) with a primary discharge diagnosis of abdominal pain, constipation, irritable bowel syndrome, dyspepsia, abdominal migraine, cyclic vomiting syndrome, or fecal incontinence. We calculated the FGID hospitalization prevalence rate, length of stay (LOS), and inflation-adjusted costs annually and assessed for statistically significant trend changes using joinpoint analyses.

KEY RESULTS: 22.3 million …

Addressing Futility: A Practical Approach, Piroska K. Kopar, Adrienne Visani, Kyler Squirrell, Douglas E. Brown

2020-Current year OA Pubs

UNLABELLED: Limiting or withdrawing nonbeneficial medical care is considered ethically responsible throughout most of critical care and medical ethics literature. Practically, however, setting limits to treatment is often challenging. We review the literature to identify best practices for using the definition of futility as an anchoring concept to aid the ethical practice of ICU clinicians.

DATA SOURCES: Source data were obtained from a PubMed literature review.

STUDY SELECTION: English language articles were chosen based on relevance to medical futility ethics, end-of-life care in the ICU, or communication and conflict mitigation strategies.

DATA EXTRACTION: Independent evaluation of selected articles for recurrent …

Dietary Supplements In People With Metastatic Cancer Who Are Experiencing Malnutrition, Cachexia, Sarcopenia, And Frailty: A Scoping Review, Jolyn Johal, Chad Yixian Han, Ria Joseph, Zachary Munn, Oluwaseyifunmi Andi Agbejule, Fiona Crawford‐Williams, Matthew P. Wallen, Raymond J. Chan, Nicolas H. Hart

Research outputs 2022 to 2026

Cancer‐associated malnutrition, or cachexia, stemming from cancer or its treatments, is particularly prevalent in metastatic cancers, and is often interrelated with sarcopenia and frailty. Evidence suggests that dietary supplements play a role in managing these conditions. As metastatic cancer cells are associated with notable genomic and phenotypic alterations, response to dietary supplements may differ between metastatic and non‐metastatic cancers. However, research in this area is lacking. This scoping review aims to identify the dietary supplements that have been studied in patients with metastatic cancers and malnutrition‐related conditions, along with their proposed effects, mechanisms, outcome measures, and tools used. A systematic …

Location-Specific Cutaneous Electrical Stimulation Of The Footsole Modulates Corticospinal Excitability To The Plantarflexors And Dorsiflexors During Standing, Gagan Gill, Davis A. Forman, Joanna E. Reeves, Janet L. Taylor, Leah R. Bent

Research outputs 2022 to 2026

Non-noxious electrical stimulation to distinct locations of the foot sole evokes location-specific cutaneous reflex responses in lower limb muscles. These reflexes occur at latencies that may enable them to be mediated via a transcortical pathway. Corticospinal excitability to the plantarflexors and dorsiflexors was measured in 16 participants using motor evoked potentials (MEPs). Spinal excitability was measured in eight of the original participants using cervicomedullary motor evoked potentials (CMEPs). Measurements were collected with and without preceding cutaneous stimulus to either the heel (HEEL) or metatarsal (MET) locations of the foot sole, and evoked potentials were elicited to coincide with the arrival …

Onasemnogene Abeparvovec For Presymptomatic Infants With Two Copies Of Smn2 At Risk For Spinal Muscular Atrophy Type 1: The Phase Iii Spr1nt Trial, Kevin A Strauss, Craig M Zaidman, Et Al

2020-Current year OA Pubs

SPR1NT ( NCT03505099 ) was a Phase III, multicenter, single-arm study to investigate the efficacy and safety of onasemnogene abeparvovec for presymptomatic children with biallelic SMN1 mutations treated at ≤6 weeks of life. Here, we report final results for 14 children with two copies of SMN2, expected to develop spinal muscular atrophy (SMA) type 1. Efficacy was compared with a matched Pediatric Neuromuscular Clinical Research natural-history cohort (n = 23). All 14 enrolled infants sat independently for ≥30 seconds at any visit ≤18 months (Bayley-III item #26; P < 0.001; 11 within the normal developmental window). All survived without permanent ventilation at 14 months as per protocol; 13 maintained body weight (≥3rd WHO percentile) through 18 months. No child used nutritional or respiratory support. No serious adverse events were considered related to treatment by the investigator. Onasemnogene abeparvovec was effective and well-tolerated for children expected to develop SMA type 1, highlighting the urgency for universal newborn screening.

The Export Of Medical Supplies And Agriculture Products In Cuba, Stephen J. Powell, Terry L. Mccoy, William A. Messina Jr., Berta Hernández-Truyol, Adrian Jorge Makuc

Florida Journal of International Law

No abstract provided.

Pills, Patents, And Power: State Creation Of Gray Markets As A Limit On Patent Rights, Shubha Ghosh

Florida Journal of International Law

The question, of course, is whether allowing gray markets for pharmaceuticals is effective. I address this question in this Article and conclude that while the gray market solution is appropriate in South Africa, its effectiveness, as proposed, is questionable in the United States. While ideally it would be more appropriate to address the problems directly as human rights matters, the solution of creating gray markets may be the most effective within the constraints of the current legal system. However, the gray market must be created in a suitable and rational fashion. I develop these points as follows. Part II presents …

Rights, Patents, Markets And The Global Aids Pandemic, James Thuo Gathii

Florida Journal of International Law

No abstract provided.

Effect Of A Commonly Used Veterinary Antibiotic On Oxidative Stress And Root Transporters Of Edible Legumes And Leafy Crops, Safaa Nassar, Jamilah Borjac

BAU Journal - Science and Technology

Antibiotic accumulation in soil and plants is a rising problem in agriculture creating a serious threat to living organisms in the environment, hence needing huge attention. To this end, glasshouse pot experiments were conducted to simulate contamination by veterinary antibiotic at 150 mg kg^-1 and 4800 mg kg^-1 in a virgin soil in which lentil (Lens culinaris Medik.), chickpea (Cicer arietinum L.), arugula (Eruca sativa Mill.) and cress (Lepidium sativum L.) were grown, aiming at evaluating the potential toxicity of antibiotic in plants roots during their growth period. Biomarkers of toxicity such as malondialdehyde and proline …

Genomic Prediction Accuracy Of Stripe Rust In Six Spring Wheat Populations By Modeling Genotype By Environment Interaction, Kassa Semagn, Muhammad Iqbal, Diego Jarquin, Harpinder Randhawa, Reem Aboukhaddour, Reka Howard, Izabela Ciechanowska, Momna Farzand, Raman Dhariwal, Colin W. Hiebert, Amidou N’Diaye, Curtis Pozniak, Dean Spaner

Department of Statistics: Faculty Publications

Some previous studies have assessed the predictive ability of genome-wide selection on stripe (yellow) rust resistance in wheat, but the effect of genotype by environment interaction (GEI) in prediction accuracies has not been well studied in diverse genetic backgrounds. Here, we compared the predictive ability of a model based on phenotypic data only (M1), the main effect of phenotype and molecular markers (M2), and a model that incorporated GEI (M3) using three cross-validations (CV1, CV2, and CV0) scenarios of interest to breeders in six spring wheat populations. Each population was evaluated at three to eight field nurseries and genotyped with …

Knowledge And Awareness Of Vitamin D Among Pregnant Or Lactating Iraqi Refugee Women: A Call For Different Approaches In Health Education And Outreach, Someireh Amirfaiz, Ed.D.

Journal of Refugee & Global Health

Vitamin D deficiency during pregnancy and lactation has negative impacts on maternal, fetal, and infant health. Low health literacy and other social determinants of health may increase the risk of deficiency among refugee women. This qualitative study used a survey and in-depth individual interviews to examine knowledge of vitamin D among ten pregnant or breastfeeding Iraqi refugee women in the United States, and sought participants’ recommendations on culture-centered and participatory health promotion strategies. All participants reported having insufficient information and understanding of vitamin D, its health benefits, and the risks of deficiency. The four primary themes that emerged from the …

The Effect Of Using Pegagan Leaves (Centella Asiatica L. Urban) Extract On The Physical Properties And Antioxidant Capacity Of Mochi Ice Cream, Yeri Ayu Safitri, Ummi Rohajatien, Laili Hidayati

Bulletin of Culinary Art and Hospitality

Pegagan leaf is a popular medicinal plant widely found in Indonesia. Pegagan can also be used in food and beverage products, such as mochi ice cream. This study aims to determine the physical properties (color and textures) and antioxidant capacity of mochi ice cream with different pegagan leaf extract concentrations of 20, 30, and 40 percent. This experimental study used a CRD (Completely Randomized Design), with treatment carried out twice for each concentration. The data obtained were analyzed using a one-way ANOVA (Analysis of Variance) test. If a real difference was observed, then the DMRT (Duncan's Multiple Range Test) was …

Saturated And Unsaturated Fatty Acids Contents Analysis In Nasi Padang Chicken Gulai And Nasi Kandar Chicken Curry, Hashim Fadzil Ariffin, Laili Hidayati, Afellia Febrianti

Bulletin of Culinary Art and Hospitality

Nasi Padang chicken gulai and Nasi Kandar chicken curry are traditional dishes made with coconut milk, thick sauce, and creamy gravy due to their lengthy processing. Chicken curry has a slightly spicy flavor, a reddish yellow sauce color, and a stronger aroma due to the addition of spices and herbs during the cooking process. This study aims to determine the saturated fatty acid and unsaturated fatty acid content in chicken gulai and chicken curry. The data of chicken gulai’s and chicken curry’s fatty acid was collected using Shimadzu’s GC (Gas Chromatography) instrument. As this study used an experimental research design, …

An Overview Of Indian Culinary Journey With Glimpse Of Regional Cuisine, Anusua Ghosh

Bulletin of Culinary Art and Hospitality

With diversity in race, religion, culture, and language, Indian cuisine is unique to each region. The varied nature of the cuisine is mainly based on what is grown and harvested, depending on the climate and region. Various spices and herbs are added to enhance the flavor and to keep the food fresh. Moreover, spices and herbs are also used for medicinal purposes. History suggests that earlier people consumed traditional food and followed the dietary rules outlined in Ayurveda. In Ayurveda, food and wellbeing are highly related, with nutrition plays as a central role in ensuring a balance of the mind, …

Consumers’ Behaviour Towards Sustainable Packaging: A Study Among The Students And Alumni Of Faculty Of Food Science And Nutrition Universiti Malaysia Sabah, Mansoor Abdul Hamid, Keneswary Ravichanthiran

Bulletin of Culinary Art and Hospitality

This study aims to identify the consumers’ behavior toward sustainable packaging. This study involved 284 students and alumni of the Faculty of Food Science and Nutrition, Universiti Malaysia Sabah. A questionnaire was used to garner the data, covering the participants’ demographic, consumers’ behavior, and meal preferences, as well as their knowledge of the benefit of sustainable packaging and the danger of migration of chemical substances into food from the food packaging. The obtained data were subjected to descriptive analysis. It is found that most of the respondents (71.5 percent) were aware of the benefits of sustainable packaging and the risk …

Farmer-Led Small-Scale Irrigation Systems Management In Highland Vegetable Farming In The Cordillera Region, Philippines, Cheryll C. Launio, Marivic O. Abyado

Journal of Economics, Management and Agricultural Development

Much has been said about large-scale and pump irrigation systems but not much published research is available on small-scale farmer-led irrigation systems supporting highland farming. This study described the management of irrigation sources and farmer-led irrigation systems, and conveyance and distribution technologies supporting highland farming. Data were based on FGDs in 30 barangays and a survey of 279 farmers in three highland provinces. Findings show that 91% of farmers use irrigation from springs, rivers, and creeks; 70% of the conveyance and distribution facilities are farmer-initiated and managed, and micro-irrigation technologies such as sprinklers and drip irrigation are accessible. National irrigation …

Is Public Corruption Still A Crime? The Effect Of Mcdonnell Narrowing Test, Kristine Artello

Journal of Criminal Justice and Law

The Supreme Court has been limiting the types of public corruption crimes since the 1990s. In 2016, the Supreme Court found that the jury instructions defined official acts too broadly and narrowed its definition significantly in McDonnell v. U.S. The Court created a two-part test to differentiate acts to help one’s constituency versus acts to help oneself because the Court was concerned with the criminalization of politics. From the ruling to March 2019, the federal courts have cited the McDonnell ruling in 151 decisions. These cases were collected and examined using context analysis to understand (in)actions of public officials that …

2021-2022 Annual Report, Southern Illinois University Board Of Trustees

Annual Report Archive

No abstract provided.

Revaksinasi Covid-19 Pada Kelompok Lansia Dengan Frailty, Ika Fitriana

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Hpv Infection And Vaccination: A Question-And-Answer Guide For School Nurses, Mendi England, Karlen E. Luthy, Michael S. Robinson

Student Works

This paper provides school nurses with a quick question-and-answer format guide to common HPV-related questions that are often asked by school aged children's parents.

Cloning, Expression And Catalytic Function Analysis Of Chitinase From Streptomyces Diastaticus, Li Qin, Wang Li-Mei, Qi Bin

Food and Machinery

Objective: This study focused on improving the production of chitosan oligosaccharides by chitinase degradation of chitin. Methods: Using genetic engineering methods to clone, prokaryotic expressing, and investigating enzymatic properties of the chitinase from Streptomyces diastaticus, and the chitinase activity was explored by homology modeling, amino acid comparison of the catalytic domain, and site-directed mutagenesis. Results: After cloning and prokaryotic expression, the enzyme production cycle was shortened from 7 d to 24 h, and the enzyme activity reached 132 U/L, which was 32% higher than the original bacterial enzyme activity (100 U/L). The amino acids that determine the activity of chitinase …

Effects Of Different Particle Sizes Of Finger Millet On The Quality, Antioxidant Ability And In Vitro Digestibility Of Wheat Bread, Xiao Pan-Fei, Xie Hua, Tao Xiao-Han, Luo Yi-Ni, Tang Yu-Hua, Li Chi-Ling

Food and Machinery

Objective: This study aimed to exploit the functional bread of finger millet. Methods: Based on the physical and chemical properties, antioxidant capacity, special digestion characteristics and sensory evaluation of bread, the effects of different particle sizes of finger millet flour on the characteristics of wheat bread were investigated. Results: Compared with the bread without finger millet powder, the bread with 200 mesh finger millet powder increased the total phenol content by 225.78%, the DPPH radical scavenging rate by 42.96% and the iron ion reduction ability by 22.97%. The finger millet powder with smaller particle size showed stronger anti-oxidation ability. Moreover, …

The Development Experience Of Front Of Package Food Warning Labeling In Chile And Its Enlightenments To China, Huang Ze-Ying

Food and Machinery

The study collected materials about front of package food warning labeling from the official website of the Chile Ministry of Health and literatures. Successful experience was summarized from the implementation background, algorithm, and implementation effect of warning labels, comparison of warning labels in other countries, and comparison with other front of package labels. And then several enlightenments were provided to optimize the front of package labeling in China.

Effects Of Natural Compound Preservative And Its Vacuum Synergy On The Shelf Life Of Pre-Conditioned Pork Filling Stuffing, Liu Ping-Yun, Wang Jun-Ru, Ding Yi-Dan, Zhang Gen-Sheng

Food and Machinery

Objective: To study the effect of food preservatives on the freshness of pre-conditioned pork filling stuffing and to solve the problem of easy spoilage and very short shelf life of pre-conditioned pork filling stuffing. Methods: The changes of physicochemical and microbiological indexes of the pre-conditioned pork filling treated with vacuum-packed co-combination preservatives during storage were determined using the total number of colonies or TBA values as evaluation criteria. Results: The optimal ratio of preservatives were as followed: 0.049% nisin, 0.207% D-isoascorbate sodium, 0.029% rosemary extract. Vacuum-packed synergistic compounding preservative treatment can effectively delay the changes of total bacterial colony, …

Effect Of Chitosan On The Waterless Preservation Of Urechis Unicinctus, Li Zhong-Kun, Li Zi-Xuan, Liu Chen-Hao, Liu Chun-E

Food and Machinery

Objective: The aim of the study was to decrease the transportation cost while reducing the nutrition loss of Urechis unicinctus. Methods: Chitosan was used for pretreatment of Urechis unicinctus, and the changes of the main nutritional and physiological indexes of the three groups i.e., control group, after waterless preservation group and recovered group, were measured. Results: The optimal concentration of chitosan was 3 g/L. After being pretreated by chitosan, the survival rate of Urechis unicinctus could reach 67% after 64 h of waterless preservation. The survival rate, muscle glycogen, water holding capacity of the experimental group were all …

Optimization Of Preparation Technology Of Ovalbumin-Peptide By Complex Enzyme And Its Antialcoholic Effect, Qi Xing-Yu, Yan Xiao-Juan, Zhang Hai-Yue

Food and Machinery

Objective: This study aimed to verify the antialcoholic activity of ovalbumin peptide and improve the added value of egg products. Methods: Ovalbumin was hydrolyzed by alkaline protease and trypsin. The activity rate of alcohol dehydrogenase (ADH) was taken as index, and the enzymolysis process was optimized by response surface methodology. The total antioxidant activity, hydrolysis degree, amino acid composition and relative molecular weight of ovalbumin peptide were determined to evaluate the antialcoholic effect of ovalbumin peptide. Results: The optimum enzymatic hydrolysis conditions were as follows. Under the conditions of enzymatic hydrolysis time 5 h, dosage of complex enzyme 3 100 …

Optimization Of Process Parameters And Antioxidant Activity Of Purslane Compound Rice, Qi Jia-Hui, Chen Shan-Feng, Yan Yu-Hong, Han Feng, Liu Xin-Hua, Li Rui-Hong

Food and Machinery

Objective: Preparation of Portulaca oleracea compound rice with antioxidant properties. Methods: Broken rice flour is the main raw material and Portulaca oleracea L. was the auxiliary material. On the basis of single factor experiment, response surface experiment was designed with comprehensive score, and the technological parameters of screw speed, barrel temperature, purslane addition and feed moisture, and the antioxidant characteristics of compound rice were detected by the clearance of DPPH and ABTS. Results: The results showed that the optimal formula for preparing purslane compound rice was the follow: The screw speed was 140 r/min, barrel temperature was 120 ℃, purslane …

Research Progress On Extraction, Purification, Analysis And Biological Activity Of Polysaccharides From Opuntia Dillenii Haw., Yang Yan, Zhou Xin, Chen Hua-Guo

Food and Machinery

In this review, the extraction, purification, structural characterization and bioactivity of polysaccharides from Opuntia dillenii Haw. were summarized. This review provides a theoretical basis for the in-depth development and utilization of the polysaccharides.

Evaluation Of The Quality Of Pumpkin Seed Flour And Capsules As Food Supplements, Aminuddin Syam

Media Kesehatan Masyarakat Indonesia

Pumpkin seeds contain a variety of useful nutrients, so they become a food supplement. This study aimed to evaluate the quality of pumpkin seed flour and capsules. This study used the experimental method. The pumpkin used came from a local market in Makassar City. Cleaned pumpkin seeds-then dried in the sun for ± 7 hours. After that, put them in the oven at a temperature of 70-75°C for 3 hours. Next, blended them until they became smooth flour and sieved through a 70 mesh sieve. Put the flour into a capsule shell size 00. The quality of pumpkin seed flour …