Digital Commons Network^™

The Importance Of Education In The Management Of Diabetes, Taylor Nicole Henry

Doctoral Dissertations and Projects

Type 2 diabetes continues to affect millions of people every day across the United States. Uncontrolled blood sugars pose a risk to individuals’ overall health by causing microvascular and macrovascular changes and ultimately lead to an earlier mortality. One’s blood sugar levels can be checked at any time, but an individual’s hemoglobin (hgb) A1c is a three-month average that allows the diabetic to have an overview on how they are managing their diabetes. Appropriate nutrition and having someone hold the diabetic accountable have proven to limit these risks by lowering the patient’s hgb A1c. Providers and staff need to do …

Walking To Improve Outcomes In Patients With Type Ii Diabetes, Kelley Leigh Sanders

Doctoral Dissertations and Projects

Walking is a simple, feasible, and effective exercise modality in which providers can instruct patients as a component of type II diabetic treatment plans. Many patients are overwhelmed when given instructions to exercise and therefore never begin. Lack of exercise contributes to poor glycemic control and adverse outcomes. Also, gym memberships can be expensive resulting in patients forgoing exercise altogether. The purpose of this DNP scholarly project was to conduct research outcomes which may enlighten providers to prescribe exercise interventions by providing evidence walking 45 minutes three times a week can improve glycemic control among type II diabetic patients. Also, …

A Phospholipid Mimetic Targeting Lrh-1 Ameliorates Colitis, Suzanne G Mays, Emma H D'Agostino, Autumn R Flynn, Xiangsheng Huang, Guohui Wang, Xu Liu, Elizabeth J Millings, C Denise Okafor, Anamika Patel, Michael L Cato, Jeffery L Cornelison, Diana Melchers, René Houtman, David D Moore, John W Calvert, Nathan T Jui, Eric A Ortlund

Faculty, Staff and Students Publications

Phospholipids are ligands for nuclear hormone receptors (NRs) that regulate transcriptional programs relevant to normal physiology and disease. Here, we demonstrate that mimicking phospholipid-NR interactions is a robust strategy to improve agonists of liver receptor homolog-1 (LRH-1), a therapeutic target for colitis. Conventional LRH-1 modulators only partially occupy the binding pocket, leaving vacant a region important for phospholipid binding and allostery. Therefore, we constructed a set of molecules with elements of natural phospholipids appended to a synthetic LRH-1 agonist. We show that the phospholipid-mimicking groups interact with the targeted residues in crystal structures and improve binding affinity, LRH-1 transcriptional activity, …

Tumor Microenvironment In Pancreatic Ductal Adenocarcinoma: Implications In Immunotherapy, Caitlyn Smith, Wei Zheng, Jixin Dong, Yaohong Wang, Jinping Lai, Xiuli Liu, Feng Yin

2020-Current year OA Pubs

Pancreatic ductal adenocarcinoma is one of the most aggressive and lethal cancers. Surgical resection is the only curable treatment option, but it is available for only a small fraction of patients at the time of diagnosis. With current therapeutic regimens, the average 5-year survival rate is less than 10% in pancreatic cancer patients. Immunotherapy has emerged as one of the most promising treatment options for multiple solid tumors of advanced stage. However, its clinical efficacy is suboptimal in most clinical trials on pancreatic cancer. Current studies have suggested that the tumor microenvironment is likely the underlying barrier affecting immunotherapy drug …

The Acute Effect Of In Natura Beetroot Juice Intake On Intra-Session Exercise Sequences During Concurrent Training, Diego Souza, Julio Ribeiro, Andrea Simão, Millán Aguilar-Navarro, Marcos Polito

International Journal of Exercise Science

International Journal of Exercise Science 15(2): 1075-1085, 2022. The purpose of this study was to analyze the acute effects of in natura beetroot juice intake on intra-session exercise sequences during concurrent training. Following a randomized double-blind placebo-controlled crossover design, 20 well-trained men (21.4 ± 2.9 years; 74.8 ± 6.3 kg; 175.7 ± 5.0 cm) performed two concurrent training sessions with different intra-session exercise sequences: CT1 (aerobic exercise + resistance exercises) and CT2 (resistance exercises + aerobic exercise). The resistance exercises were bench-press, lat-pull down, and shoulder-press (three sets to failure; 2 s cadence for the concentric and eccentric phases; 90 …

Prognostic Nutritional Index As A Predictor Of Prognosis In Patients With Chronic Limb Threatening Ischemia Who Underwent Endovascular Revascularization Therapy, Wai Kin Chi, Gm Tan, Bryan Py Yan

Journal of the Hong Kong College of Cardiology

BACKGROUND/INTRODUCTION: Patients with chronic limb-threatening ischemia (CLTI) have poor prognosis. Prognostic nutritional index (PNI) is an established independent predictor of adverse outcome in various chronic illnesses. The use of PNI in patients with CLTI has not been studied.

PURPOSE: To evaluate the impact of PNI on 12-month adverse cardiovascular and limb outcomes in CLTI patients after endovascular revascularization therapy (ERT).

METHODS: 270 consecutive patients with CLTI (mean age 73.7±11.9 years; 53% male) who underwent ERT at a single tertiary referral hospital between January 2009 and October 2016 were prospectively enrolled and analyzed. Patients were grouped by tertiles of PNI (lowest …

Snp Genotyping For Purity Assessment Of A Forage Oat (Avena Sativa L.) Variety From Colombia, Luis Fernando Campuzano-Duque, Diego Bejarano-Garavito, Javier Castillo-Sierra, Daniel Ricardo Torres-Cuesta, Andrés J. Cortés, Matthew Wohlgemuth Blair

Agricultural and Environmental Sciences Faculty Research

Single nucleotide polymorphism (SNP) markers have multiple applications in plant breeding of small grains. They are used for the selection of divergent parents, the identification of genetic variants and marker-assisted selection. However, the use of SNPs in varietal purity assessment is under-reported, especially for multi-line varieties from the public sector. In the case of variety evaluation, these genetic markers are tools for maintaining varietal distinctness, uniformity and stability needed for cultivar release of multi-line or pure-line varieties of inbred crops. The objective of this research was to evaluate the purity and relationships of one original (AV-25) and two multi-line sub-populations …

Growth Outcomes Of Pseudomonas Aeruginosa Inhibitor Of Vertebrate Lysozyme Knockouts In Conditions Mimicking The Cystic Fibrosis Lung Environment, Amani Gaddy

Master of Science in Chemical Sciences Theses

Pseudomonas aeruginosa (PA) is a Gram-negative bacterium, often found in cystic fibrosis (CF) patients and can lead to the decline of lung functioning and premature death in 80% of infected patients when microcolonies form within the mucin of the lung. Due to its major capacity for antibiotic resistance, an alternative strategy towards defending against the bacterial invasion of PA is by the antibacterial activity of our own innate immune system with use of elements such as lysozyme. Pseudomonas aeruginosa inhibitor of vertebrate lysozyme class 1 (Ivyp1) is a periplasmic protein produced by gram-negative bacteria that inhibits the enzymatic activity of …

A Commentary On The Healthy Community Stores Case Study Project: Implications For Retailers, Policy, And Future Research, Samantha M. Sundermeir, Megan R. Winkler, Sara John, Uriyoán Colón-Ramos, Ravneet Kuar, Ashley Hickson, Rachael D. Dombrowski, Alex B. Hill, Bree Bode, Julia Deangelo, Joel Gittelsohn

Urban Studies and Planning Faculty Research Publications

In the United States, low-income, underserved rural and urban settings experience poor access to healthy, affordable food. Introducing new food outlets in these locations has shown mixed results for improving healthy food consumption. The Healthy Community Stores Case Study Project (HCSCSP) explored an alternative strategy: supporting mission-driven, locally owned, healthy community food stores to improve healthy food access. The HCSCSP used a multiple case study approach, and conducted a cross-case analysis of seven urban healthy food stores across the United States. The main purpose of this commentary paper is to summarize the main practice strategies for stores as well as …

Knowledge Overconfidence Is Associated With Anti-Consensus Views On Controversial Scientific Issues, Nicholas Light, Philip M. Fernbach, Nathaniel Rabb, Mugur V. Geana, Steven A. Sloman

Business Faculty Publications and Presentations

Public attitudes that are in opposition to scientific consensus can be disastrous and include rejection of vaccines and opposition to climate change mitigation policies. Five studies examine the interrelationships between opposition to expert consensus on controversial scientific issues, how much people actually know about these issues, and how much they think they know. Across seven critical issues that enjoy substantial scientific consensus, as well as attitudes toward COVID-19 vaccines and mitigation measures like mask wearing and social distancing, results indicate that those with the highest levels of opposition have the lowest levels of objective knowledge but the highest levels of …

Inhibitory Effect Of Sea Cucumber Coelomic Fluid Extracts On White Shrimp Autolysis, Nie Bin, Li Ao-Ting, Cui Xiao-Fan, Du Yi-Nan, Yan Jia-Nan, Wu Hai-Tao

Food and Machinery

Objective:In this paper, the inhibition of protein degradation in autolysis of white shrimp (Penaeus vannamei) surimi by extracts from the coelomic fluid of sea cucumber (Stichopus japonicus), a by-product of sea cucumber processing, was studied.Methods:The protein degradation in autolysis of white shrimp was studied by SDS-PAGE assay. Furthermore, the effect of sea cucumber coelomic fluid and its extracts on white shrimp protein degradation was determined by SDS-PAGE and TCA-soluble oligopeptide assay.Results:The optimal conditions of white shrimp autolysis were incubation at pH 3.0, 50 ℃ for 2 h. The bond intensities of myosin heavy chain around …

Dynamic Changes Of Volatile Flavor Components And Their Precursors During Low Temperature Cooking Of Beef, Cui Wei, Meng Xiang-Ren, Gao Zi-Wu, Ma Yin-Rui

Food and Machinery

Objective:In order to explore the dynamic changes of volatile flavor components and their precursors during low temperature cooking of beef.Methods:Beef with central temperature of 98 ℃ was used as control group. Nucleotides, free amino acids, free fatty acids, total sugars and volatile flavor components in beef with central temperature of 60, 65, 70, 75 and 80 ℃ were determined, and sensory evaluation was carried out.Results:The results showed that the content of fresh flavor nucleotides, equivalent fresh flavor concentration and taste activity in the low temperature group were significantly higher than those in the control group …

Effect Of Sulfate Modificate On The Structure And Antioxidant Activity Of Jujube Polysaccharide, Gong Xiao-Pei, Zhang Jian, Guo Xiao-Bin, Mao Xiao-Ying, Zhang Lian-Fu

Food and Machinery

Objective:This study aimed to explore the relationship between the structure and antioxidant activity of purified red date polysaccharide ZJP-1 and sulfated red date polysaccharide S-ZJP-1.Methods:Using remnant jujube as raw material, jujube polysaccharide (ZJP-1) was purified by hot water extraction, and then separated by DEAE-52 ion exchange chromatography and Sephadex-200 dextran gel column chromatography. Thereafter, red jujube polysaccharide sulfated derivative (S-ZJP-1) was obtain through chlorosulfonic acid-pyridine sulfated modification.Results:Both ZJP-1 and S-ZJP-1 are composed of three monosaccharides: glucose, arabinose, and galactose, but the ratios are different. The two polysaccharides had characteristic absorption peaks of polysaccharides, and S-ZJP-1 …

Study On Composition Difference And Antioxidant Activity Of Peel And Kernel From Raw And Fried Semen Of Ziziphi Spinosae, Xiao Feng-Qin, Liu Hui, Yang Yi-Liu, Yu Qian, Li Jia, Zhang Hong-Yin, Shao Shuai, Li Guang-Zhe, Yan Ming-Ming

Food and Machinery

Objective:This study aimed to reveal the composition differences and antioxidant activities of kernel and peel from raw and fried semen from Ziziphi spinosae.Methods:Using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical, hydroxyl radical (·OH), superoxide anion radical (O-2·), 2,2'-amino-di (3-ethyl-benzothiazoline-6-sulphonic acid) ammonium salt (ABTS) free radical scavenging ability and ferric reducing antioxidant power (FRAP) to determine the antioxidant activity of peel, kernel and jujube benevolence from different semen. Moreover, the components of peel, kernel and jujube benevolence were also studied by UV spectrophotometer.Results:The results showed that the peel, kernel, and jujube benevolence of all the semen had certain antioxidant …

Research On Network Food Safety Supervision Strategy Under The Background Of "Internet Plus", Wang Li-Hua

Food and Machinery

Firstly the research background and the current status of online food safety research were introduced, and then the current status and problems of online food supervision were analyzed in this review. Finally, some supervision strategies were proposed in four ways, i.e., the construction of a smart collaborative supervision platform, the reform of supervision organization and power reshaping, the breaking information asymmetry and the strengthening of consumer rights protection.

Melon Weak Microwave-Assisted Hot Air Drying Characteristics And Mathematical Model, Zhang Jian-Chao, Bai Yu-Jia, Feng Zuo-Shan, Zheng Li-Ping, Dilinur Jakefu

Food and Machinery

Objective:Using Xinjiang melon as raw material, explore melon slices in weak microwave-assisted hot air drying in the process of drying characteristics.Methods:UsingR2,χ2 and RMSE as evaluation indexes, compare melon slices of wet basis moisture content under different conditions, the drying rate, moisture content than the distinction, and melon dry dynamics model was set up, and the drying characteristic curve of melon slices was gotten at different slice thickness, the cycle time of microwave, the hot air cycle time.Results:The thinner the slice, the longer the circulation drying time of microwave and dry hot air, the faster the …

Optimization Of Preparation Technology And Antioxidant Activity Of Enzymatic Hydrolysates From Corneum Gigerii Galli Endothelium, Zhang Hui-Ying, Yang Wei-Qiao, Chen Yao, Li Pan, Du Bing

Food and Machinery

Objective:In order to study the optimal enzymatic hydrolysis process conditions of corneum galli gigerii endothelium, and analyze the amino acid composition, molecular weight distribution and antioxidant activity of the enzymatic hydrolysate.Methods:With the yield of polypeptide and the degree of hydrolysis as indicators, the orthogonal experiment was used to optimize the enzymatic hydrolysis conditions of corneum galli gigerii endothelium. Amino acid analyzer and high-performance gel permeation chromatography were used to determine the amino acid composition and molecular weight distribution of the enzymatic hydrolysate of corneum galli gigerii endothelium. The clear ability of corneum galli gigerii endothelium to DPPH …

Study On Preparation Of Collagen Peptides From Micropterus Salmoides Skin And Its Antioxidant Activity, Han Meng-Yao, Li Xin-Yue, Wang Xiao-Mei, Wang Guo-Zhi, Ye Jin-Yun, Zhang Zhong-Shan

Food and Machinery

Objective:Collagen was extracted from the skin of Micropterus salmoides and used to explore the effect of enzyme types on the antioxidant activity of collagen peptides.Methods:Four kinds of enzymes were used, namely alkaline protease, neutral protease, papain and trypsin. The enzymatic hydrolysis of collagen Alkaline protease enzymatically hydrolyze collagen peptide (APP), Neutral protease enzymatically hydrolyze collagen peptide (NPP), Papain enzymatically hydrolyze collagen peptide(PP), Trypsin hydrolysis of collagen peptide(TP), were obtained and compared their total antioxidant activity, including reducing activity, DPPH, ·OH and O-2·free radical scavenging ability, ferrous ion chelating ability and lipid Oxidation inhibitory activity.Results:Four kinds …

Quality Properties Of Mixture Of The Proso Millet And Rice, Ren Jing, Jiang Wen-Qian, Zhao Ning, Ji Xiao-Hui, Li Meng-Qing, Du Shuang-Kui

Food and Machinery

Objective:The purpose of this study was to mix rice and proso millets and obtain high nutritional value, fantastic taste and flavor mixed rice.Methods:By adding different proportions of proso millets to rice, the nutritional value and fantastic taste of mixed rice were evaluated via the amino acid score (AAS), texture profile properties, sensory evaluations and flavor properties.Results:There were significant differences in the texture profile properties, sensory evaluations and flavor properties among cooked proso millets additions. The proportion of the cooked rice addition was significantly positively correlated to the gumminess and chewiness of rice, while it was …

Optimum Parameters And Application Of Buckwheat Noodle Composite Preformed Powder, Zhao Min, Yang Bao-Wei, Hu Jian, Wang Rong-Lan

Food and Machinery

Objective:This study aimed to explore the best parameters of buckwheat noodle composite preformed powder.Methods:Single factor experiment, multi-index comprehensiveevaluation method and orthogonal experiment were used to optimize the special composite preformed powder recipe of buckwheat noodles.Results:The best parameters of buckwheat noodle composite preformed powder were 45% of buckwheat flour, 8% of modified starch, 1.2% of compound phosphate and 3% of gluten powder. In this situation, the tensile area of composite flour dough was 3 378.6 g·mm; the stabilization time was 7.23 min, the content of wet gluten was 23.71%; the sensory score was89.2; the comprehensive score …

Advance In Research On Heat Treatment Mechanism Of Infrared Radiation And Its Application In Foods, Yu Xian-Long, Chu Bin, Xiao Hong-Wei, Zhang Wei-Peng, Zhao Feng, Zhang Zong-Chao

Food and Machinery

The development of food infrared heating theories were discussed in this review, and the advancement of infrared heating in food processing were summarized. Moreover, the principle of food processing and process optimum method in various food infrared thermal treatment technologies, including sterilizing, thawing, blanching, baking, peeling and drying processes were also discussed.

Research Progress On Composition And Processing Of Flos Lonicerae, Luo Lian, Ye Meng, Lin Jing, Chen An-Jun, Mo Han-Ru, Yu Jian-Bing, Liu Xing-Yan

Food and Machinery

In this paper, the research on the active components, dry processing methods, extraction of functional components and processed products of Flos Lonicerae at home and abroad in recent years were summarized and discussed, and the development direction of Flos Lonicerae in the future was prospected.

School And Community Drivers Of Child Diets In Two Arab Cities: The Scale Protocol And Innovative Tools To Assess Children's Food Environments, Hala Ghattas Ph.D., Zeina Jamaluddine, Aline Semaan, Nehmat El-Helou, Gloria Safadi, Tatiana Elghossain, Christelle Akl, Shady Elbassuoni, Ali Chalak, Jalila El Ati

Faculty Publications

Background

In the context of the rapid nutrition transition experienced by middle-income countries of the Arab region, children and adolescent's food choices and dietary behaviors are early risk factors for the development of non-communicable diseases. Assessment of factors influencing food choices among this age group is challenging and is usually based on self-reported data, which are prone to information and recall bias. As the popularity of technologies and video gaming platforms increases, opportunities arise to use these tools to collect data on variables that affect food choice, dietary intake, and associated outcomes. This protocol paper describes the SCALE study (School …

"Don't Look Up" Your Science-Herd Immunity Or Herd Mentality?, Botond Z Igyártó

Department of Microbiology and Immunology Faculty Papers

This analysis piece will attempt to examine some of the critical pandemic-related measures implemented in the United States from an immunological perspective and pinpoint caveats that should have been considered before their implementation. I also discuss alternative measures grounded in scientific data that were not thoroughly explored and likely could have helped fight the pandemic.

Functional, Diagnostic And Therapeutic Aspects Of Bile, Monjur Ahmed

Division of Gastroenterology and Hepatology Faculty Papers

Bile is a unique body fluid synthesized in our liver. Enterohepatic circulation preserves bile in our body through its efficient synthesis, transport, absorption, and reuptake. Bile is the main excretory route for bile salts, bilirubin, and potentially harmful exogenous lipophilic substances. The primary way of eliminating cholesterol is bile. Although bile has many organic and inorganic contents, bile acid is the most physiologically active component. Bile acids have a multitude of critical physiologic functions in our body. These include emulsification of dietary fat, absorption of fat and fat-soluble vitamins, maintaining glucose, lipid, and energy homeostasis, sustenance of intestinal epithelial integrity …

A Brief Report Relating Physical Activity And Depressive Symptoms In Women During The Covid-19 Pandemic, Kim Hollingdale, Casey Mace Firebaugh, Stephanie M. Morgan

All Faculty Scholarship for the College of Education and Professional Studies

Purpose.

The purpose of this study was to investigate the association between self-reported physical activity and depressive symptoms in US women during the COVID-19 pandemic.

Methods.

A quantitative self-report online survey was administered to adult women (n > 800) in the United States during the COVID-19 pandemic in 2020. Physical activity was measured for frequency, intensity, and duration by using Likert scales, along with descriptive measures of types of activity. The Beck Depression Inventory II was applied to assess depressive symptoms.

Results.

The Beck Depression Inventory II score of participants not engaging in physical activity (b = 13.344, …

School And Community Drivers Of Child Diets In Two Arab Cities: The Scale Protocol And Innovative Tools To Assess Children’S Food Environments, Hala Ghattas Ph.D., Zeina Jamaluddine, Aline Semaan, Nehmat El-Helou, Gloria Safadi, Tatiana Elghossain, Christelle Akl, Shady Elbassuoni, Ali Chalak, Jalila El Ati, The Scale Research Group

Faculty Publications

Background

In the context of the rapid nutrition transition experienced by middle-income countries of the Arab region, children and adolescent’s food choices and dietary behaviors are early risk factors for the development of non-communicable diseases. Assessment of factors influencing food choices among this age group is challenging and is usually based on self-reported data, which are prone to information and recall bias. As the popularity of technologies and video gaming platforms increases, opportunities arise to use these tools to collect data on variables that affect food choice, dietary intake, and associated outcomes. This protocol paper describes the SCALE study (School …

The Influence Of Closed/Open Conditions On The Flavoring Compounds Produced From Tyrosine-Based Maillard Reaction, Yin Xiao-Qing, Li Rui, Pei Qi, Lu Zi-Qi, Zhao Ming-Qin

Food and Machinery

Objective:This article is aimed to explore the influence of closed/open conditions on the flavor compounds of Maillard reaction.Methods:The species and amounts of flavor compounds produced from Tyrosine-based Maillard reactions under closed/open conditions in different solvents and reaction temperatures were determined by GC-MS.Results:The results showed that the species and contents of flavor products are quite different under closed and open conditions. The amounts of alcohol flavor compounds were higher in closed system, while the amount of esters and ketones were higher inopensystem.Conclusion:The amounts of active oxygen and intermediates produced during the reactions likely result …

Mineral Element Discrimination Of Selenium-Enriched Rice In Ningxia And Its Quality Evaluation, Yang Xiao-Chen

Food and Machinery

Objective:The element content and physical and chemical quality were analyzed from the nutritional quality of Selenium (Se)-enriched rice in Ningxia.Methods:25 rice samples from different brands in Ningxia were selected as the research object, and 26 mineral elements in which were determined by inductively coupled plasma mass spectrometry (ICP-MS), and multivariate statistical analysis of these elements was conducted.Results:Through the analysis of the difference of element content between Se-enriched rice and ordinary rice, the quality of Se-enriched rice was distinguished. Moreover, it was found that Se-enriched rice was rich in four kinds of elements such as Ca, …

Non-Destructive Classification And Quality Evaluation Of Proso Millet Cultivars Using Nir Hyperspectral Imaging With Machine Learning, Laruen E. Doyle, Julia R. Loeb, Nader Ekramirad, Dipak K. Santra, Akinbode A. Adedeji

Department of Agronomy and Horticulture: Faculty Publications

Millet is a small-seeded cereal crop with big potential and remarkable characteristics such as high drought resistance, short growing time, low water footprint, and the ability to grow in acidic soil. There is a need to develop nondestructive methods for differentiation and evaluation of the quality attributes of different of proso millet cultivars grown in the U.S. Current methods of cultivar classification are either subjective or destructive, time consuming, not allowing for the whole population to be tested, and requiring trained operators and special equipment. In this study, the feasibility of using near-infrared (NIR) hyperspectral imaging (900-1700 nm) to predict …