Digital Commons Network^™

Investigating The Role Of The Transcriptional Coregulator Cited2 In Regulating Intermediate Progenitor Proliferation And Modulating Behavior, Nikolaus R. Wagner

Dissertations - ALL

The mammalian neocortex develops from a thin layer of neuroepithelial cells into a robust mosaic of differentiated neurons organized into distinct layers and functional areas. This process requires a complex choreography of transcription factors and epigenetic regulators to be spatially and temporally activated in a precise manner. Disruptions in any aspect of this delicate process may lead to neurodevelopmental disorders like autism spectrum disorder, schizophrenia, or intellectual disability. One such transcriptional coregulator that is a crucial regulator of neocortical development is Cited2. Previous work demonstrated that forebrain-specific Cited2 loss-of-function causes a reduction in neocortical progenitor proliferation which leads to reduced …

Assembling Enslaved Lives: Labor, Consumption, And Landscapes In The Northern Shenandoah Valley, Matthew Clark Greer

Dissertations - ALL

This dissertation is a study of the lives of some of the people enslaved on rural plantations and farmsteads in the northern Shenandoah Valley region of Virginia. Scholars did not widely acknowledge the presence of slavery in the Valley before the 1990s, and this is the first work to provide an in-depth view of the lives of enslaved Shenandoahans before 1860. Specifically, this project answers two questions: what was life like for enslaved people in the Shenandoah Valley, and how did they shape the region's political economies. Data for this project comes from archaeological excavations at the main enslaved quartering …

Freyre’S Plantation Playground: The Changing Landscape Of The Sugar Plantation Monjope, Catherine Elizabeth Lavoy

Dissertations - ALL

This dissertation investigates the changing landscape of the sugar plantation Monjope in Pernambuco, Brazil from the mid-seventeenth to the end of the twentieth century. I examine this plantation’s changing landscape as part of a number of larger social, economic and environmental forces; in particular the development of racially based labor. Established in the sixteenth century, Monjope was one of the many Brazilian sugar plantations that relied on African slavery for labor until the end of the nineteenth century. I argue the plantation’s built environment in conjunction with the larger plantation landscape was part of a global trend of controlling labor …

Campus Educators Selected As Inaugural Wow! Faculty Fellows, Pam Starling

University of Mississippi News

New workshops and learning communities to create vibrant online courses offered this fall

Chap-Child: An Open Source Method For Estimating Sit-To-Stand Transitions And Sedentary Bout Patterns From Hip Accelerometers Among Children., Jordan A. Carlson, Nicola D. Ridgers, Supun Nakandala, Rong Zablocki, Fatima Tuz-Zahra, John Bellettiere, Paul R Hibbing, Chelsea Steel, Marta M. Jankowska, Dori E. Rosenberg, Mikael Anne Greenwood-Hickman, Jingjing Zou, Andrea Z. Lacroix, Arun Kumar, Loki Natarajan

Manuscripts, Articles, Book Chapters and Other Papers

Background: Hip-worn accelerometer cut-points have poor validity for assessing children's sedentary time, which may partly explain the equivocal health associations shown in prior research. Improved processing/classification methods for these monitors would enrich the evidence base and inform the development of more effective public health guidelines. The present study aimed to develop and evaluate a novel computational method (CHAP-child) for classifying sedentary time from hip-worn accelerometer data.

Methods: Participants were 278, 8-11-year-olds recruited from nine primary schools in Melbourne, Australia with differing socioeconomic status. Participants concurrently wore a thigh-worn activPAL (ground truth) and hip-worn ActiGraph (test measure) during up to 4 …

Location-Specific Psychosocial And Environmental Correlates Of Physical Activity And Sedentary Time In Young Adolescents: Preliminary Evidence For Location-Specific Approaches From A Cross-Sectional Observational Study., Adrian Ortega, Carolina M Bejarano, Christopher C Cushing, Vincent S. Staggs, Amy Papa, Chelsea Steel, Robin P. Shook, Terry L. Conway, Brian E. Saelens, Karen Glanz, Kelli L. Cain, Lawrence D. Frank, Jacqueline Kerr, Jasper Schipperijn, James F. Sallis, Jordan A. Carlson

Manuscripts, Articles, Book Chapters and Other Papers

Background: A better understanding of the extent to which psychosocial and environmental correlates of physical activity are specific to locations would inform intervention optimization.

Purpose: To investigate cross-sectional associations of location-general and location-specific variables with physical activity and sedentary time in three common locations adolescents spend time.

Methods: Adolescents (N = 472,Mage = 14.1,SD = 1.5) wore an accelerometer and global positioning systems (GPS) tracker and self-reported on psychosocial (e.g., self-efficacy) and environmental (e.g., equipment) factors relevant to physical activity and sedentary time. We categorized each survey item based on whether it was specific to a location to generate psychosocial …

Addressing Food Insecurity: A Qualitative Study Of Undergraduate Students' Perceptions Of Food Access Resources., Amanda G. Conrad, Terezie Tolar-Peterson, Antonio J. Gardner, Tianlan Wei, Marion W. Evans

Faculty Publications

Food insecurity has emerged as a leading health care problem in the United States, impacting college students’ health, well-being, and academic performance. The aims of this study were: (1) to assess the prevalence of food insecurity, (2) to identify college students’ perceptions about food access resources, and (3) to explore students’ expressed needs from the university in improving food security status. A mixed-methods approach was used to assess the quantitative and qualitative aspects of the study aims. An online survey to gather demographic information and assess food security status using the 6-item version of the US Household Food Security Scale …

Practicing Food Solidarity: Garden Biodiversity, Culturally Important Foods, And Diets Of Immigrant Farmworker Communities Accessing Emergency Food Pantries, Rebecca Leigh Garofano

Theses - ALL

No abstract provided.

Nla28 Activator Modulates Σ54-Dependent Gene Regulation In Myxococcus Xanthus, Muqing Ma

Dissertations - ALL

The complex life cycle of Myxococcus xanthus makes it a model organism for studying multicellular developmental processes in bacteria. In response to environmental changes, M. xanthus cells collectively and dramatically adjust their morphology, physiological functions, and biosynthesis. Particularly, M. xanthus copes with starvation by producing fruiting bodies filled with dormant and stress-resistant spores. During secondary metabolism, it synthesizes polyketide (PK) and non-ribosomal peptide (NRP) natural products that are crucial sources of antibiotics. Bacteria including M. xanthus, require the alternative σ54 regulatory system to initiate the transcription of necessary genes for settling stress and completing developmental process. This dissertation introduces in …

Phytochemical Analysis, Antioxidant And Anticancer Effects Of Clitoria Ternatae Extract On Breast T47d Cancer Cells, Ade Arsianti, Shahjahan Pasha Mahindra, Norma Nur Azizah, Ajeng Megawati Fajrin, Lince Dameria Nadapdap

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: Breast cancer is one of the most common and deadly forms of cancer in the world. Cancer is a multi-factorial disease. Genetic factors, environment and lifestyle have a role in the development of cancer. One of the mechanisms of cancer development is when an imbalance between free radicals and antioxidants in the human body occurs. Uncontrolled and excessive amount of free radicals and cause cell damage and uncontrolled cell growth. Clitoria ternate is a plant that is often found in Asia and many of the benefits of this flower have been studied. This study aims to determine the phytochemical …

Molecular Docking Of Vitamin D3 Receptor (Vdr) With Potential Herbal Substance As Ligand To Prevent Excessive Hair Loss In Menopausal Women, Aditya Parawangsa, Syailendra Karuna Sugito, Ariestiana Ayu Ananda Latifa, Nadya Dinda Safira, Shafa Ayuthaya, Raissa Rahmalia Az Zahra

Indonesian Journal of Medical Chemistry and Bioinformatics

Hair loss is commonly found in menopausal women. Hair loss is one of the consequences of hormonal dynamics when a woman stops having menstrual cycle, which affect calcium and vitamin D level in the body. Although it is clear enough that hormonal adjustment is required, older people and another sociodemographic factor prefer herbal-based therapeutic rather than synthetic-based due to tradition and positive experience factors. This study is an in-silico study which aims to point out the possible ligand candidates that can work as Vitamin D Receptor (VDR) agonists. We perform molecular docking using Autodock version 4.2 with the criteria of …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Twelve startups Selected in First Batch of Savannah Logistics Innovation Center and Plug and Play’s Accelerator Program
• The Image in the Mirror or the Number on the Scale, Which Counts? When it Comes to Depression, it’s a Weighted Issue.

Efficacy And Safety Of Sintilimab Plus Xelox As A Neoadjuvant Regimen In Patients With Locally Advanced Gastric Cancer: A Single-Arm, Open-Label, Phase Ii Trial, Honghai Guo, Ping'an Ding, Chenyu Sun, Peigang Yang, Yuan Tian, Yang Liu, Scott Lowe, Rachel Bentley, Yaru Li, Zhidong Zhang, Dong Wang, Yong Li, Qun Zhao

Student Publications

Background: Neoadjuvant chemotherapies have been widely recommended in patients with locally advanced gastric cancer (LAGC). However, the evidence of combining neoadjuvant chemotherapy with anti-programmed death 1 (anti-PD-1) antibody therapy for patients with LAGC is lacking. Thus, we conducted a single-arm phase II trial to evaluate the efficacy and safety of the anti-PD-1 antibody sintilimab plus XELOX regimen (capecitabine plus oxaliplatin) in patients with LAGC.

Methods: Patients with LAGC (cT3-4 N+ M0, CY0, P0) were enrolled and received four preoperative cycles of sintilimab (200 mg, IV, Q21d) plus XELOX (oxaliplatin 130 mg/m2, IV, d1 with capecitabine 1,000 mg/m2, bid, d1-d14, Q21d) …

Curating Conflict: The Material Record Of The Philippine-American War At The Oregon Historical Society, Silvie M. Andrews

Dissertations and Theses

1898 marked the beginning of U.S. colonialism in the Philippines and the formation of the Oregon Historical Society (OHS), an organization that would later inherit a vast collection of Philippine and Spanish war booty from the defunct Battleship Oregon Museum. This thesis will explore the meaning of this war booty by recreating the context around its collection, accession, interpretation, and later descent into obscurity, drawing on the Battleship Oregon Collection of the OHS Research Library and institutional records of the OHS Museum as well as secondary sources that explore the colonial context around museum collecting. The first chapter will show …

Statistical Validation Of Risk Alleles In Genetic Addiction Risk Severity (Gars) Test: Early Identification Of Risk For Alcohol Use Disorder (Aud) In 74,566 Case-Control Subjects, Kenneth Blum, Mark S Gold, Et Al.

2020-Current year OA Pubs

Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and severe alcoholism in

Extrinsic Motivation To Use Mhealth Interventions In Maternal Healthcare In Rural Malawi, Priscilla Maliwichi, Wallace Chigona, Address Malata

African Conference on Information Systems and Technology

mHealth interventions have the potential to address the inequalities in accessing health information. In maternal healthcare, mHealth interventions provide information to pregnant women on how they can stay healthy during pregnancy, as well as on the danger signs in pregnancy that can contribute to maternal mortality. In this study we posit that extrinsic motivation could promote trialability of mHealth interventions. We employed qualitative research methods to investigate extrinsic factors that motivate maternal healthcare clients in rural Malawi to use mHealth interventions. Self-determination theory was used as the theoretical lens for the study. Data was collected using secondary data sources and …

Early Eruption Of All Permanent Teeth, Including The Upper Canines, In A Nine-Year-Old Child Who Was Born Prematurely; Case Report, Bassam Ali Al-Turaihi, Israa Hussein Ali

Maaen Journal for Medical Sciences

The world health organization (WHO) define the premature birth as a birth occur before 37 weeks of gestation or if the birth weight is below 2500 g. Our case subjected for both criteria of the preterm definition. ((1)) ((2)) The case was born before 31st week with 1300 g birth weight with stormy beginning of life in the first three months in the hospital according to the history taken from general practitioner (GP) for that reason their parents tack care about his general health and specifically oral health and development. Throughout his life he developed healthy with no medical problem. …

Concordance In Caregiver And Child Sleep Health Metrics Among Families Experiencing Socioeconomic Disadvantage: A Pilot Study, Lauren Covington, Aditi Satti, Benjamin Brewer, Rachel Blair, Ilona Duffy, Jean-Phillipe Laurenceau, Shannon Mayberry, Angeni Cordova, Elissa Hoopes, Freda Patterson

Journal of Applied Research on Children: Informing Policy for Children at Risk

Purpose: Child and caregiver sleep occurs in a family system, with socioeconomically disadvantaged families experiencing disproportionately worse sleep health than more advantaged families. The extent to which objectively measured sleep health metrics (i.e., sleep duration, midpoint, regularity, efficiency) are concordant within disadvantaged family systems, including caregiver-child dyads, is not clear. To address this gap, this study aimed to: (1) characterize sleep health metrics and (2) identify levels of sleep health concordance among caregiver-child dyads living in families experiencing socioeconomic disadvantage.

Design and methods: We enrolled 20 caregivers and 26 children in this micro-longitudinal study. Eligible primary caregivers slept in …

Sugar Shenanigans: Curbing The Added Sugar Epidemic In Children And Adolescents, Amy Krazl, Tonia Mailow

Faculty & Staff Research and Creative Activity

Background: The consumption of added sugar is one of the most dangerous problems regarding the health of society’s youngest generation. Children today consume added sugar at an alarming rate, on average surpassing the daily limit recommended by the American Heart Association. This study aims to educate and empower the child and adolescent population for the purpose of increasing knowledge and improving dietary practices. Methods: An educational program, entitled “Sugar Shenanigans” was delivered to groups of children between the ages of 8 and 13. Data was gathered from pre- and post-tests and “Impact Level Questionnaire” surveys for both participants and parents/guardians …

Efficacy Of Various Interventions For Achieving Target Hba1c Levels For Patients With Type Ii Diabetes Mellitus And On Exogenous Insulin, Caitlin S. Welch, Archie Troxel

Longitudinal Scholar's Project

Objective: To learn the rates at which patients at UT Family Medicine–St. Francis (UTFM–SF) with type II diabetes mellitus are being prescribed recommended medications—namely metformin, sodium-glucose cotransporter 2 (SGLT2) inhibitors, and glucagon-like peptide 1 receptor agonists (GLP1RAs)—whether these rates correspond to the severity of hyperglycemia (as indicated by HbA1C level). A secondary goal of the study was to investigate if HbA1C levels are being checked at recommended intervals.

Methods: A retrospective chart review was conducted using records of patients seen at the clinic in the previous four years between the ages of 18 and 65 who had visits with ICD …

September 1, 2022: Agenda, University Of North Dakota

University Senate Meeting Minutes

Agenda for the September 1, 2022, meeting of the University Senate. 28 pages

Vol.50 N.05 August 25th 2022, Voice Media Ventures

Black Voice News

No abstract provided.

Girls In Stem! Elementary Afterschool Six-Week Curriculum, Jess Li, Samavi Rafique

Honors Program: Expanded Learning Clubs

No abstract provided.

Continuous Glucose Monitoring Metrics For Earlier Identification Of Pre-Diabetes: Protocol For A Systematic Review And Meta-Analysis, Sara Gottfried, Laura Pontiggia, Andrew B. Newberg, Gregory Laynor, Daniel A. Monti

Institute of Emerging Health Professions Faculty Papers

Introduction: Glycaemic variability and other metrics are not well characterised in subjects without diabetes. More comprehensive sampling as obtained with continuous glucose monitoring (CGM) may improve diagnostic accuracy of the transition from health to pre-diabetes. Our goal is to investigate the glycaemic system as it shifts from health to pre-disease in adult patients without diabetes using CGM metrics. New insights may offer therapeutic promise for reversing dysglycaemia more successfully with dietary, nutritional and lifestyle change before progression occurs to pre-diabetes and diabetes.

Methods and analysis: This systematic review will include comprehensive searches of the PubMed, Scopus, Cochrane Library and ClinicalTrials.gov …

Biophilic Architecture Used To Improve Patient Outcomes And Recovery In Behavioral Health Centers, Heidy M. Valdez

Theses

Humans naturally seek adventure and the outdoors. Currently, US institutions that care for people with chronic illnesses, severe injuries, and mental health conditions often exist in neutral spaces with little to no natural elements. Because this does not promote patient happiness, patient recovery time tends to be longer. These institutions are usually not pleasant for patients or their relatives and are seen as negative spaces by the public, which should not be the case. Typical design elements include windows with thick daylight-blocking mullions to ensure no patient tries to hurt themselves, small and dark rooms, white walls, and no private …

A Step Toward An Interfaith Visitation Ministry To Provide Spiritual, Social, And Emotional Support To The Seriously Ill And Elderly At Their Homes In The Community Served By Good Samaritan Medical Center Lafayette, Colorado, Grant Gill Kirksey

Doctoral Dissertations and Projects

The purpose of this Doctor of Ministry action research thesis is to identify the support offered to the seriously ill and elderly by local faith-based communities, to compare the identified interventions provided, to discuss the population’s needs and satisfaction with their local hospitals, and to discuss the results in the context of the population of seriously ill and elderly community members, and explore opportunities for Good Samaritan Medical Center (GSMC), Lafayette, Colorado, to partner with local religious communities to improve the well-being of the seriously ill and elderly in their community. This project will include the analysis of needs and …

Health Related Challenges Of Rural Elderly Living In Co-Residential Family Care Arrangements, Kidus Yenealem Mefteh

The Qualitative Report

Family plays an indispensable role in the care and support of the rising number of older people particularly in developing countries like Ethiopia where the system of public transfer is minimal. Previous studies in Ethiopia focus on institutionalized and urban-dwelling elderly with little attention to the elderly in the informal care paradigm and rural areas. This study aims to explore the health-related experiences of dependent rural elderly who get care and support within a family setting. A phenomenology method was used, and in-depth interviews were employed to collect data from purposively sampled elders. Data were inductively coded and developed into …

Impacts Of A Workplace-Based Weight-Control Intervention On Objective And Perceived Physical Activity Among A Subgroup Of Workers, Rachel Tabak, Ryan Colvin, Jaime R Strickland, Ann Marie Dale, Maura Kepper, Tara Ruggeri, Bradley Evanoff

2020-Current year OA Pubs

Physical activity (PA) has many benefits; however, groups facing barriers to health-promoting behaviors are less likely to be physically active. This may be addressed through workplace interventions. The current study employs objective (accelerometry) and perceived (International Physical Activity Questionnaire [IPAQ]) measures of PA among a subset of participants from the "Working for You" study, which tests a multi-level (work group and individual) workplace intervention targeted at workers with low-incomes. Linear mixed and hierarchical logistic regression models are used to determine the intervention's impact on moderate- to vigorous-PA (MVPA) and achieving the PA Guideline for Americans (≥150 minutes MVPA/week), respectively from …

Modelling Neurological Diseases In Large Animals: Criteria For Model Selection And Clinical Assessment, Samantha L Eaton, Jonathan D Cooper, Et Al.

2020-Current year OA Pubs

No abstract provided.

Women And Land Snails Consumption In The Southwest Region Of Cameroon, Forka Leypey Mathew Fomine

Journal of International Women's Studies

Both marine and terrestrial species of snails are consumed in most countries worldwide, including Southwest Cameroon where it is an age-old practice among various ethnic groups. Before the introduction of snail farming in the Southwest Region of Cameroon in the 1990s, all the residents who ate snails acquired them through gathering.

There is significant internal variation in the history of land snail consumption among four ethnic groups: the Banyang, Mbo, Balung, and Bakweri. The long history of land snail consumption among the Banyang and Mbo can be attributed to their geographical proximity to the eastern region of Nigeria, where the …