Digital Commons Network^™

Epacadostat Plus Pembrolizumab And Chemotherapy For Advanced Solid Tumors: Results From The Phase I/Ii Echo-207/Keynote-723 Study, John D Powderly, Samuel J Klempner, Aung Naing, Johanna Bendell, Ignacio Garrido-Laguna, Daniel V T Catenacci, Matthew H Taylor, James J Lee, Fred Zheng, Feng Zhou, Xiaohua Gong, Hema Gowda, Gregory L Beatty

Faculty, Staff and Student Publications

Background: Epacadostat, an oral, selective inhibitor of IDO1, has shown activity when administered with pembrolizumab. We evaluated the addition of chemotherapy to epacadostat and pembrolizumab in patients with advanced or metastatic solid tumors. One proposed mechanism of resistance to PD-1 checkpoint inhibition is through immunosuppression mediated by L-kynurenine. IDO1, indoleamine-2,3-dioxygenase 1 is the rate-limiting enzyme catalyzing the conversion of L-tryptophan to L-kynurenine. If IDO1 is a mechanism of tumor escape from checkpoint inhibition, then addition of an IDO1 inhibitor with a PD-1 checkpoint inhibitor could enable tumor response to immunotherapy.

Methods: Patients received one of 7 tumor-appropriate chemotherapy regimens. Pembrolizumab …

Zebras Of All Stripes Repel Biting Flies At Close Range, Kaia J. Tombak, Andrew S. Gersick, Lily V. Reisinger, Brenda Larison, Daniel I. Rubenstein

Publications and Research

The best-supported hypothesis for why zebras have stripes is that stripes repel biting flies. While this effect is well-established, the mechanism behind it remains elusive. Myriad hypotheses have been suggested, but few experiments have helped narrow the field of possible explanations. In addition, the complex visual features of real zebra pelage and the natural range of stripe widths have been largely left out of experimental designs. In paired-choice field experiments in a Kenyan savannah, we found that hungry Stomoxys flies released in an enclosure strongly preferred to land on uniform tan impala pelts over striped zebra pelts but exhibited no …

A Comprehensive Review On Nutraceuticals: Therapy Support And Formulation Challenges, Vivek Puri, Manju Nagpal, Inderbir Singh, Manjinder Singh, Gitika Arora Dhingra, Kampanart Huanbutta, Divya Dheer, Ameya Sharma, Tanikan Sangnim

Faculty, Staff and Student Publications

Nutraceuticals are the nourishing components (hybrid of nutrition and pharmaceuticals) that are biologically active and possess capability for maintaining optimal health and benefits. These products play a significant role in human health care and its endurance, most importantly for the future therapeutic development. Nutraceuticals have received recognition due to their nutritional benefits along with therapeutic effects and safety profile. Nutraceuticals are globally growing in the field of services such as health care promotion, disease reduction, etc. Various drug nutraceutical interactions have also been elaborated with various examples in this review. Several patents on nutraceuticals in agricultural applications and in various …

Survey Tools For Measuring Research Or Evidence‐Based Practice Constructs In Dietetics: A Narrative Review, Rosa K. Hand

Faculty Scholarship

Background: Exact quantification of research conducted by dietitians and tracking the effectiveness of interventions or training programs to increase either evidence-based practice (EBP) or research behaviours have been hampered by the variety of tools used to measure these constructs. Methods: In this narrative review, we identified and classified the various tools previously used to measure constructs related to research and/or EBP in the dietetics profession, and to summarise estimates of the constructs measured. Results: We identified and classified 15 scored tools that had been used at least once in the dietetics profession and extracted tool parameter estimates from 22 resulting …

The Student Movement Volume 107 Issue 7: Hot Drinks & Hayrides: Barn Party Comes To Campus, Kavya Mohanram, Anna Pak, Amelia Stefanescu, Solana Campbell, Lily Rodriguez, Hannah Cruse, Nicholas C. Gunn, Alannah Tjhatra, Nora Martin, Terika Williams, Grace No, Valerie Akinyi, Ralph Gifford, Abraham Bravo, Gloria Oh, Melissa Moore

The Student Movement v. 107 (2022-2023)

HUMANS

Meet David Springer: AUGSA President, Interviewed by: Kavya Mohanram

Meet Rock Choi: AUSA Presidential Assistant, Interviewed by: Anna Pak

Women in Stem: Minseo Kang, Interviewed by: Anna Pak

ARTS & ENTERTAINMENT

Creatives on Campus: Passion Through A New Lens, Amelia Stefanescu

Currently..., Solana Campbell

Fatphobic or Sensitive?, Lily Rodriguez

Take 3: Is Love Truly Blind?, Hannah Cruse

NEWS

AUSA & AFIA End Filipino American History Month On A High Note, Nicholas C. Gunn

AUSA Hosts Barn Party, Alannah Tjhatra

Honors Outing to Chicago Shakespeare Theater, Nora Martin

IDEAS

Reader's Digest: Midterm Election, Terika Willliams

The Death of the Rom-Com, …

Interior Landscape Techniques And Its Contribution To The Interior Places Environmentally, Amany Ahmed Mohamed, Lamis Elgizawi, Nanees Abd Elhamid Elsayyad

Mansoura Engineering Journal

Understanding the benefits of interior landscape can help environmental sustainability as a major concern within interior design field because over the life cycle of a building, ecological interior design can reduce negative effects and increase beneficial benefits on environmental systems. Humans have used technological advancements to improve their work environment where they spend most of their time separated from nature and urban landscaping. This affects users’ healthand causes diseases such as sick building syndrome (SBS), the users’ comfort and work performance because of the pollutant emitted from the office equipment. Previous research has demonstrated the importance of indoor plants in …

The Childhood Acute Illness And Nutrition (Chain) Network Nested Case-Cohort Study Protocol: A Multi-Omics Approach To Understanding Mortality Among Children In Sub-Saharan Africa And South Asia, James M. Njunge, Kirkby Tickell, Abdoulaye Hama Diallo, Abu Sadat Mohammad Sayeem Bin Shahi, Md Amran Gazi, Ali Faisal Saleem, Zaubina Kazi, Syed Ali, Caroline Tigoi, Ezekiel Mupere

Department of Paediatrics and Child Health

Introduction: Many acutely ill children in low- and middle-income settings have a high risk of mortality both during and after hospitalisation despite guideline-based care. Understanding the biological mechanisms underpinning mortality may suggest optimal pathways to target for interventions to further reduce mortality. The Childhood Acute Illness and Nutrition (CHAIN) Network ( www.chainnnetwork.org) Nested Case-Cohort Study (CNCC) aims to investigate biological mechanisms leading to inpatient and post-discharge mortality through an integrated multi-omic approach.
Methods and analysis; The CNCC comprises a subset of participants from the CHAIN cohort (1278/3101 hospitalised participants, including 350 children who died and 658 survivors, and …

Older Adults Access To Mental Health And Social Care Services During Covid-19 Restrictions In Western Australia, Claire Adams, Eyal Gringart, Daniel Mcaullay, Moira Sim, Brigitta Scarfe, Amy Budrikis, Natalie Strobel

Research outputs 2022 to 2026

Objective: This study aimed to understand the impact of COVID-19 on access to mental health and social services among older adults in Western Australia. Method: A cross-sectional study was conducted with 194 adults aged ≥ 70 years or ≥ 60 years with chronic conditions. A questionnaire co-developed by a consumer reference group was used to collect data on social networks and service access. Frequency analyses were used to assess quantitative data. Qualitative data were assessed using thematic analyses. Results: 62.7 % of participants reported being not at all/slightly affected by COVID-19; 40.7 % reported having three/four people to chat with. …

Impact Of Rma’S Projected Price On Prevent Planting Claims, Nicolas Enrique Alvarez Mena

LSU Master's Theses

This research studies the presence of ex-post moral hazard in the prevent planting provision from the crop insurance program in cotton, corn, and soybeans for the Plains Region and Southeast Regions of the U.S. Three fixed effect models are developed using the proportion of prevent plant acres as the dependent variable, as well as weather, input price, expected harvest price and a break-even point for the independent variables. In addition, a fourth fixed effect (FE) model is introduced using the logit transformation and the same variables as in previous models. The results show the number of PP claims has been …

From Biowaste To Product: The Functionalization Of Biochar For Agricultural And Environmental Applications, Baoyue Zhou

LSU Doctoral Dissertations

Biochar is a porous carbonated substance that is manufactured through pyrolysis of biomass feedstocks in an oxygen-deficiency environment. The production of biochar from agricultural waste materials provides a potential solution for eliminating pollution while improving carbon sequestration. While biochar is shown to provide multiple benefits to soil health and fertility, its use in environmental remediation has been hampered by its low affinity for hazardous anionic species and the difficulty in isolating from water phase. To overcome these obstacles, various efforts have been made to modify biochar surface chemistry and morphology.

Fe/Mg co-doped biochar composites from sugarcane harvest residue were prepared …

Children’S Experiences Of Hospitalization Over Time: An Evaluation Of Using Poetry And Creative Writing By Children To Assess Their Experiences Of Hospitalization, David Wood

Patient Experience Journal

This article explores children’s experiences of hospital admissions through their poetry and creative writing and assesses the validity of this medium compared to other methods of evaluation. Pediatric patient experiences of hospital and their effects on children have been studied in various ways and there have been stepwise changes throughout the past century, matching the overall changes of medical care from paternalistic to patient centered. 17 poems were analyzed from children aged 6-13 years old (median 10) for recurrent themes whilst admitted to a large tertiary hospital in the north of England. Children frequently wrote about attacks on their senses, …

Decision Support For Grassland Systems In Developing Countries, P. K. Thornton

IGC Proceedings (1977-2023)

Key points

1. Information flows in complex systems are often themselves highly complex, and decision support approaches based on linear input-output processes may have only limited impact.

2. How decisions are made, and how they can be appropriately supported, is often incompletely understood, in part because of inadequate understanding of the objectives and attitudes of all the decision makers involved.

3. Much of the developing world faces daunting problems in the coming 30 years, and appropriate information could play a critical role in dealing with these.

4. System complexity, household variability, and institutional intricacies have to be embraced rather than …

November 2, 2022 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

Evaluation Of Nurse Burnout And Currently Used Prevention And Treatment Interventions, Karina Burton

Doctor of Nursing Practice Scholarly Project

The purpose of this scholarly project was to determine the feelings of nurse burnout and intervention techniques utilized and available to registered nurses at a regional medical center in the Midwest on a Cardiac-Telemetry unit. A survey was provided to 61 registered nurses to evaluate the feelings of nurse burnout and evaluate intervention resources available to gain a better understanding of the feelings of burnout on a Cardiac-Telemetry unit.

Gardner-Webb Officials And Supporters Break Ground On Masters-Melton Indoor Baseball Facility, Office Of University Communications

Gardner-Webb NewsCenter Archive

While celebrating Gardner-Webb’s rich past, Homecoming festivities also looked ahead to the University’s bright future. The groundbreaking ceremony for the Masters-Melton Indoor Baseball Facility accomplished both.

Development Of An Emergency Medicine Pharmacy Intensity Score Tool, Kyle A. Weant, Nicole M. Acquisto, Cassandra R. Doyno, Haili Gregory, Megan A. Rech, Cory J. Schlobohm, Andrew P. Smith, Kimberly J. Won

Pharmacy Faculty Articles and Research

Purpose

Emergency medicine pharmacists (EMPs) have been demonstrated to have a positive impact on patient outcomes in a variety of clinical scenarios in the emergency department (ED), yet their distribution across the nation is suboptimal. An emergency medicine pharmacy intensity score tool (EMPIST) would not only facilitate the quantification of EMP staffing needs and ideal resource deployment times, but would also allow practitioners to triage patient care activities. The purpose of this investigation was to develop an EMPIST and evaluate its relationship to EMP activities.

Methods

This was a multicenter, prospective, observational analysis of an EMPIST developed by practicing EMPs. …

Campus Chronicle, Lily Hastings, Maria Hernandez, Emily Houck, Nick Longo, Alyssa Monroe, Alex Seavers, Andy Langager

Campus Chronicle

No abstract provided.

Synthesis, Characterization And Cell Viability Of Novel Tripodal Amines, Kinsley Lupton

Honors College Theses

Cancer, over the years, has become a much more prevalent focus for the scientific community. Organizations and laboratories all over the world have spent countless hours searching for a cure, trying to learn more about what makes cancer so powerful and what is the best way to stop its growth. Iron-chelation drugs were already on the market, and it was shown that they did have the ability to act as both iron-chelators and anticancer drugs. Most of these iron-chelating drugs are not as effective at killing cancer cells as the medical field desires. Novel iron-chelating tris-indolyl derivatives, GSO2, GSO4 and …

Integrating Leadership Strategies In Your Curriculum, Kim Boyd, Jay Gary

Academy Resources

Dr. Boyd welcomes and introduces the session. Dr. Gary discusses how students develop their leadership identity by developing various competencies. ORU focuses on developing the competencies, or University outcomes, of spiritual integrity, personal resilience, intellectual pursuit, global engagement, and bold vision to help develop whole leaders for the whole world. Dr. Gary continues to share how faculty may implicitly and explicitly integrate a variety of leadership resources through instructional strategies and in the curriculum. Dr. Boyd concludes by reviewing the leadership components within the ORU teaching excellence framework domains.

Resource 1: ORU University Outcomes

Resource 2: ORU Teaching …

Theragnostic Radionuclide Pairs For Prostate Cancer Management, Anupriya Chhabra, Mathew L Thakur

Department of Radiology Faculty Papers

Prostate cancer (PCa) is one of the preeminent causes of mortality in men worldwide. Theragnostic, a combination of therapy and diagnostic, using radionuclide pairs to diagnose and treat disease, has been shown to be a promising approach for combating PCa. In PCa patients, bone is one of the most common sites of metastases, and about 90% of patients develop bone metastases. This review focuses on (i) clinically translated theragnostic radionuclide pairs for the management of PCa, (ii) radionuclide therapy of bone metastases in PCa, and (iii) a special emphasis on emerging theragnostic radionuclide pair, Copper-64/Copper-67 (⁶⁴Cu/⁶⁷Cu) …

Creating A Culture That Supports Food Security And Health Equity At Higher Education Institutions, Mateja R. Savoie-Roskos, Lanae B. Hood, Rebecca L. Hagedorn-Hatfield, Matthew J. Landry, Megan M. Patton-López, Rickelle Richards, Jody L. Vogelzang, Zubaida Qamar, Kendra Oonorasak, Georgianna Mann

Nutrition, Dietetics, and Food Sciences Faculty Publications

Food insecurity on college campuses is a major public health problem and has been documented for the last decade. Sufficient food access is a crucial social determinant of health, thus campuses across the country have implemented various programs, systems and policies to enhance access to food which have included food pantries, campus gardens, farmer’s markets, meal share or voucher programs, mobile food applications, campus food gleaning, food recovery efforts, meal deliveries, and task force/working groups. However, little is understood about how to best address food insecurity and support students who are struggling with basic needs. The impact of food insecurity …

Office Of Research, Economic Engagement And Outreach Update, November 2, 2022, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

A Roadmap To Understanding Diversity And Function Of Coral Reef-Associated Fungi, Anna Roik, Miriam Reverter, Claudia Pogoreutz

School of Biological and Marine Sciences

Tropical coral reefs are hotspots of marine productivity, owing to the association of reef-building corals with endosymbiotic algae and metabolically diverse bacterial communities. However, the functional importance of fungi, well known for their contribution to shaping terrestrial ecosystems and global nutrient cycles, remains underexplored on coral reefs. We here conceptualize how fungal functional traits may have facilitated the spread, diversification, and ecological adaptation of marine fungi on coral reefs. We propose that functions of reef-associated fungi may be diverse and go beyond their hitherto described roles of pathogens and bioeroders, including but not limited to reef-scale biogeochemical cycles and the …

Identification Of Quantitative Trait Loci (Qtls) For Resistance To Bacterial Leaf Streak: Xanthomonas Translucens Using Qtl And Association Mapping In Three Populations Of Soft Red Winter Wheat, Benjamin Tyler Meritt

LSU Doctoral Dissertations

Bacterial leaf streak (BLS) and black chaff, caused by Xanthomonas translucens pv. undulosa (Xtu), can be a very destructive disease of wheat, especially in the warmer, wetter areas of the Southeastern U.S. Yield losses of up to 40 percent have been recorded in some cases in southern wheat growing regions. With no effective agronomic or chemical method of disease control, identification of genetic resistance is seen as a promising solution. Three soft red winter wheat populations (GAWN, ARK-SNP, and AGS 2060- AGS 2035 DH) representative of soft red winter wheat germplasm in the southeastern U.S. developed by …

Back Matter

The Journal of Purdue Undergraduate Research

No abstract provided.

Alumni Spotlight: Hyesoo Chae

The Journal of Purdue Undergraduate Research

Hyesoo Chae published an article in volume 7 (2017) of the Journal of Purdue Undergraduate Research during her time spent completing her baccalaureate degree.

Impact Of Adolescent Social Isolation On Adult, Binge-Like Ethanol Consumption And Plasma Corticosterone In High-Alcohol-Preferring Mice, Eva Cullins

The Journal of Purdue Undergraduate Research

Adolescent stress exposure increases the likelihood of alcohol misuse and alcohol use disorder (AUD) in adulthood; however, it is not clear how genetic and environmental factors interact to increase risk. This study examined how adolescent social isolation affects adult binge-like ethanol drinking and levels of the stress hormone corticosterone in male and female mice with a genetic predisposition toward high alcohol preference (HAP). Twenty-eight HAP mice were separated into group-housed (GH) and socially isolated (SI) conditions (n = 13, 13). Binge drinking was assessed using a drinking in the dark (DID) procedure. Blood samples were taken before DID and after …

Exploring The Impact Of The Habitat For Humanity Home-Building Process On Partner Families' Holistic Well-Being, Hawkley Pusey, Nikhil Mathur, Kathryn Figliomeni, Nanditha Srinivasan, Keely R. Dehn, Jason A. Ware

Purdue Journal of Service-Learning and International Engagement

The purpose of this study was to evaluate how participating in the Habitat for Humanity house-building process influenced participants’ purpose well-being, social well-being, community well-being, physical and mental well-being, and financial well-being, and how effective Habitat for Humanity is in aiding neighborhood revitalization within the Greater Lafayette area. The research project resulted in a presentation of quantitative data and a testimonial video that highlighted the stories of families that had worked with Habitat for Humanity. Quantitative data was gathered through a survey that addressed respondents’ levels of satisfaction within the various categories of well-being mentioned above. Testimonial information was gathered …

Taking A Closer Look At The Codes List-Cookbooks For Gender And Academic Holdings, Jennifer Ottinger, Mlis Usm Slis

SLIS Connecting

It is time to consider if cookbooks hold this disparity and closely look at the gender of authors in the culinary world. This study explored gender within the CODES List-Cookbooks 2019-2022, a juried list of cookbooks published 2018-2021, as well as determined if Texas public colleges and universities carry these titles. By evaluating this juried list of recommended cookbooks, libraries can use the research to take a closer look at their cookbook collection. The purpose of this study was to examine and analyze cookbooks from the CODES List- Cookbooks, 2019-2022, and ownership of the books by public colleges and universities …

Daily Announcements November 2022, Wofford College. Office Of Marketing And Communications

Communications Office Daily Announcements

No abstract provided.