Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 40681 - 40710 of 241269

Full-Text Articles in Entire DC Network

Federal Food Safety Framework: Where Does Seaweed Fit In?, Catherine M. Janasie Dec 2022

Federal Food Safety Framework: Where Does Seaweed Fit In?, Catherine M. Janasie

Journal of Food Law & Policy

When one mentions seaweed as food, what do you think of? The dried nori used to wrap your sushi roll or perhaps the seaweed salad on the side? In fact, seaweed has many uses, including as both a food source in its own right and as a food additive. While the seaweed market has been dominated by East Asian countries, seaweed is cultivated in about 50 countries, and the U.S. seaweed industry is steadily growing. The global seaweed industry is currently worth about $6 billion annually. Food products for human consumption account for about 85% of this value.


Following The Framework: Intentional Genomic Alterations In Animals, Sarah Copper Dec 2022

Following The Framework: Intentional Genomic Alterations In Animals, Sarah Copper

Journal of Food Law & Policy

Intentional genomic alterations in animals or genetically engineered animals have existed in their modern form since the 1980s. However, the introduction of these animals into our food supply has been a more recent development. The federal government has taken steps in an attempt to regulate these products in a streamlined and efficient manner but has faced criticism in their approach. While the Food and Drug Administration (“FDA”) is currently responsible for the regulation of intentional genomic alterations (“IGAs”) in animals, there is significant effort behind transferring that oversight to the United States Department of Agriculture (“USDA”). However, in the meantime, …


Managing Non-Mulesed Sheep, Department Of Primary Industries And Regional Development, Western Australia Dec 2022

Managing Non-Mulesed Sheep, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

The Department of Primary Industries and Regional Development (DPIRD) has been involved in a variety of research projects to help producers manage non mulesed sheep. Research has shown that it is possible to successfully manage non-mulesed sheep with little extra time or cost.


Successful Creation Of Seedless (Sterile) Leucaena Germplasm Developed From Interspecific Hybridisation For Use As Forage, Daniel Real, Clinton K. Revell Dr, Yong Han, Chengdao Li, Marieclaire Castello, C. D. Bailey Dec 2022

Successful Creation Of Seedless (Sterile) Leucaena Germplasm Developed From Interspecific Hybridisation For Use As Forage, Daniel Real, Clinton K. Revell Dr, Yong Han, Chengdao Li, Marieclaire Castello, C. D. Bailey

Grain and Other Field Crops Research Articles

Context: The legume shrub/tree leucaena (Leucaena leucocephala (Lam.) de Wit.) is highly regarded as a cattle fodder, although it is considered an environmental weed in many parts of Australia.

Aims: We investigated the feasibility of developing a forage variety of triploid leucaena through interspecific hybridisation that is sterile (without seeds) as a strategy to mitigate its weed risk.

Methods: A conventional breeding strategy was used to create triploid hybrids from hand-crosses between tetraploid and diploid species of leucaena. Molecular markers were developed to confirm successful crosses and flow cytometry was used to confirm the ploidy level. The plants are being …


Neurocognitive And Momentary Assessment Of Fear-Based Mechanisms Underlying The Transition From Partial To Full Remission In Anorexia Nervosa., Caroline Christian Dec 2022

Neurocognitive And Momentary Assessment Of Fear-Based Mechanisms Underlying The Transition From Partial To Full Remission In Anorexia Nervosa., Caroline Christian

Electronic Theses and Dissertations

Background. Anorexia nervosa (AN) is a serious psychiatric illness, with high mortality, chronicity, and societal costs. Many individuals with AN that are weight restored do not to fully remit from cognitive-affective symptoms (e.g., fear of weight gain) maintaining the disorder, contributing to the poor outcomes. This critical stage of AN is called partial remission. AN is characterized by high levels of fear and avoidance, which may prevent full remission; however, the role of fear-based mechanisms (i.e., fear approach; avoidance) in partially-remitted AN remains untested. Methods. In the current study (N = 55 partially-remitted AN), participants completed two behavioral paradigms …


Examining Effective And Realized Healthcare Access In The West South Central Division., Katherine Cameron Dec 2022

Examining Effective And Realized Healthcare Access In The West South Central Division., Katherine Cameron

Electronic Theses and Dissertations

This study explores realized and effective access domains outlined by Andersen’s Behavioral Model of Health Services Use. Exploring other domains of access is critical to understanding how the healthcare system functions (Kirby & Yabroff, 2020). This study evaluates rural-urban and racial/ethnic differences in access to care using two underresearched domains of healthcare access. It also allows for exploring access disparities within rural communities amongst minority populations. This dissertation is divided into five chapters. Chapter One provides an overview of health disparities and inequities and a brief overview of the study. Chapter Two details a high-level history of racism and its …


Death Of A Bacterium: Exploring The Inhibition Of Staphylococcus Aureus By Burkholderia Cenocepacia., Tiffany Brandt Dec 2022

Death Of A Bacterium: Exploring The Inhibition Of Staphylococcus Aureus By Burkholderia Cenocepacia., Tiffany Brandt

Electronic Theses and Dissertations

Antimicrobial resistance is a phenomenon of increasing concern as antimicrobial overuse and misuse eliminate current therapeutic options, ushering society into a post-antimicrobial era. Antibiotic discovery and synthesis efforts are urgently needed to counter the increasing burden of antimicrobial resistance. Staphylococcus aureus is a causative agent of a variety of clinical manifestations including bacteremia, endocarditis, soft tissue infection, osteomyelitis, and device-related infections. S. aureus infection presents additional treatment challenges due to its capacity for biofilm formation, which is a mode of growth that confers protection from antibiotics and physical elimination, and the emergence of antibiotic resistant strains, including methicillin-resistant S. aureus …


Metabolic Foundations Of Exercise-Induced Cardiac Growth., Kyle Fulghum Dec 2022

Metabolic Foundations Of Exercise-Induced Cardiac Growth., Kyle Fulghum

Electronic Theses and Dissertations

Regular aerobic exercise promotes physiological cardiac growth, which is an adaptive response thought to enable the heart to meet higher physical demands. Cardiac growth involves coordination of catabolic and anabolic activities to support ATP generation, macromolecule biosynthesis, and myocyte hypertrophy. Although previous studies suggest that exercise-induced reductions in cardiac glycolysis are critical for physiological myocyte hypertrophy, it remains unclear how exercise influences the many interlinked pathways of metabolism that support adaptive remodeling of the heart. In this thesis project, we tested the general hypothesis that aerobic exercise promotes physiological cardiac growth by coordinating myocardial metabolism to promote glucose-supported anabolic pathway …


Re-Engineering Cardio-Oncology Testing Using Biomimetic Heart Slice Cultures., Jessica Miller Dec 2022

Re-Engineering Cardio-Oncology Testing Using Biomimetic Heart Slice Cultures., Jessica Miller

Electronic Theses and Dissertations

28% of drug withdrawal from the market are due to unforeseen disruptions in cardiomyocyte contractility and electrophysiology. The most commonly used platforms for drug testing are in vivo animal models and in vitro cell culture models. While both have been of paramount importance for the discovery and detection of many cardiotoxicities and mechanisms of action, they lack the ability to model an intact human myocardium. This work aims to establish cardiac tissue slices, which are 300-micron thin tissue sections taken from the left ventricular myocardium, as an alternative platform for cardio-oncology studies, specifically cardiotoxicity testing. Additionally, this work aims to …


Systematic Review Of A Ramsar Wetland And Unesco Biosphere Reserve In A Climate Change Hotspot (Ichkeul Lake, Tunisia), Sabrine Sahbani, Béchir Béjaoui, Sihem Benabdalla, Rachid Toujani, Afef Fathalli, Noureddine Zaaboub, Jalel Aouissi, Zeineb Kassouk, Nabil Hamdi, Nabiha Ben Mbarek, Hechmi Missaoui, Leila Basti, Reginald Blake, Hamidreza Norouzi Dec 2022

Systematic Review Of A Ramsar Wetland And Unesco Biosphere Reserve In A Climate Change Hotspot (Ichkeul Lake, Tunisia), Sabrine Sahbani, Béchir Béjaoui, Sihem Benabdalla, Rachid Toujani, Afef Fathalli, Noureddine Zaaboub, Jalel Aouissi, Zeineb Kassouk, Nabil Hamdi, Nabiha Ben Mbarek, Hechmi Missaoui, Leila Basti, Reginald Blake, Hamidreza Norouzi

Publications and Research

Tunisia's Ichkeul Lake is among the most productive ecosystems in the Mediterranean, with a great regional value thanks to its diversity of habitats. It is an important overwintering area for waterfowl species. It is a RAMSAR wetland, a National Park, a UNESCO World Heritage, and a Biosphere Reserve. This review paper provides a broad overview of the climatic, hydraulic, biogeochemical features, bio-resources, and bio-productivity of the Lake. The interconnectivity between the different environmental components of the lake is presented, highlighting the main characteristics of this vital ecosystem. Its ecosystem consists of a permanent lake bordered by temporary marshes. It is …


An Interprofessional Prediabetes And Diabetes Self--Management Education Quality Improvement Project Among Vulnerable Populations At A Tuberculosis Hospital, Robert Saul Castro Natal Dec 2022

An Interprofessional Prediabetes And Diabetes Self--Management Education Quality Improvement Project Among Vulnerable Populations At A Tuberculosis Hospital, Robert Saul Castro Natal

Doctor of Nursing Practice

Background. Patients greatly benefit from diabetes self-management education (DSME) as it boosts knowledge and self-efficacy, decreases body weight, fasting blood sugar, and hemoglobin A1C levels, and improves overall health outcomes in a cost-effective manner. Unfortunately, many individuals with prediabetes and diabetes who qualify for DSMEs do not attend these classes nor receive sufficient prediabetes and diabetes support elsewhere to attain guideline recommended metrics. However, individuals from vulnerable populations and without DSME education experience disproportionate diabetes-related complications worsening health outcomes. Aims: Increase general prediabetes and diabetes knowledge, facilitate behavior change, improve glycemic, metabolic, and lipid values, and increase …


Implementing Food Insecurity Screening On A College Campus, Norma Martinez Dec 2022

Implementing Food Insecurity Screening On A College Campus, Norma Martinez

Doctor of Nursing Practice

Background. Students attending universities have higher rates of food insecurity than U.S. households. Most college campuses do not routinely screen students for food insecurity, which can affect students’ health and school performance. Currently, the university health clinic does not screen students for food insecurity. Purpose. To screen all students who present to the university clinic for food insecurity and evaluate students with food insecurity for malnutrition. Evidence. Foreman et al. (2018) and Abu and Oldewage-Theron (2019) found that food insecurity was present at some of the largest Texas universities at rates higher than the national average. Project Objectives. To screen …


Addressing Obstacles In Following Prescribed Medication Regimens In Patients With Type 2 Diabetes Mellitus, Cristina Sarro Dec 2022

Addressing Obstacles In Following Prescribed Medication Regimens In Patients With Type 2 Diabetes Mellitus, Cristina Sarro

Doctor of Nursing Practice

Background. Type 2 diabetes is the ninth leading cause of death in the United States. Micro/macro vascular complications are common in diabetes. Purpose. To implement an evidence-based protocol addressing obstacles for patients with type 2 diabetes in following their prescribed medication regimens to reduce glycosylated hemoglobin levels. Evidence. Failure to follow treatment plans increases diabetes complications. Perceptions and complexities of treatment plans, side effects of therapies, and cost contribute to patients not taking their medications as prescribed. Goals. To increase the number of patients with type 2 diabetes who follow their prescribed medication regimen and reach their targeted glycosylated hemoglobin. …


Implementing The Depression Screening Tool Phq-9 In The Annual Wellness Exam Of Concierge Family Medicine, Eric Iglesias Dec 2022

Implementing The Depression Screening Tool Phq-9 In The Annual Wellness Exam Of Concierge Family Medicine, Eric Iglesias

Doctor of Nursing Practice

Abstract

Background: Depression has been one of the most common mental health disorders that our population fact but is underdiagnosed and undertreated. Primary care providers are often the first line of defense in detecting depression. Because of this, implementing a depression screening tool in a primary care setting will improve holistic management of care and improve quality of life.

Project Aim: The aim of this project was to increase the number of clients who are evaluated for depression by using the PHQ-9 screening tool during their annual wellness exam and initiate treatment according to the Veteran’s Affairs/Department of Defense Depression …


Essential Property, Timothy M. Mulvaney, Joseph William Singer Dec 2022

Essential Property, Timothy M. Mulvaney, Joseph William Singer

Minnesota Law Review Vols. 106:2 onward (2021-present)

For a sizable swath of the U.S. population, incomes and wealth are insufficient to cover life’s most basic necessities even in the most ordinary of times. A disturbingly resilient explanation for this state of affairs rests on the view that resource inequities are avoidable through self-reliance, a stance that invites observers to see people in poverty as morally suspect. This Article advances a counterview in contending that the widespread lack of essential resources did not simply arise naturally via individuals’ life choices but instead has been, in very meaningful part, created and perpetuated by our system of property laws. The …


Efficacy Of A Typical Clean-In-Place Protocol Against In Vitro Membrane Biofilms, Diwakar Singh, Sanjeev Anand Dec 2022

Efficacy Of A Typical Clean-In-Place Protocol Against In Vitro Membrane Biofilms, Diwakar Singh, Sanjeev Anand

Dairy Science and Food Science Faculty Publications: 2022 to Present

This study evaluates the effectiveness of a typical clean-in-place (CIP) protocol against in vitro biofilms on whey reverse osmosis (RO) membranes developed under static condition. Bacterial isolates obtained from RO membrane biofilms were used to develop single and multispecies biofilms under laboratory conditions. A typical commercial CIP protocol was tested against the 24-h-old biofilms, and included 6 sequential treatment steps based on alkali, surfactant, acid, enzyme, a second surfactant, and a sanitizer treatment step. Experiments were conducted in 4 replicates and the data were statistically analyzed. The results revealed a variation in the resistance of mixed-species biofilms against the individual …


U-Glide Program Fall 2022, Unf Office Of Undergraduate Research, Unf Graduate School Dec 2022

U-Glide Program Fall 2022, Unf Office Of Undergraduate Research, Unf Graduate School

Undergraduate – Graduate Learning, Inquiry, and Distinctive Experimentation (U-GLIDE) Symposium Programs

No abstract provided.


Assessing Knowledge And Perceptions About Cancer Among American Indians Of The Zuni Pueblo, Nm, Safia Safi, Donica Ghahate, Jeanette Bobelu, Andrew L. Sussman, Joseph Rodman, Angela Wandinger-Ness, Shiraz I. Mishra, Thomas Faber, Cheryl Willman, Vallabh Shah Dec 2022

Assessing Knowledge And Perceptions About Cancer Among American Indians Of The Zuni Pueblo, Nm, Safia Safi, Donica Ghahate, Jeanette Bobelu, Andrew L. Sussman, Joseph Rodman, Angela Wandinger-Ness, Shiraz I. Mishra, Thomas Faber, Cheryl Willman, Vallabh Shah

Pathology Research and Scholarship

American Indians (AIs) in New Mexico have lower cancer screening rates compared to other populations and are more likely to be diagnosed with cancer at an advanced stage of the disease as reported by Li et al. (Archives of Internal Medicine 163(1):49-56, 2003). AIs also have the lowest 5-year cancer survival rates compared to any ethnic/racial group in the USA as reported by Clegg et al. (Arch Intern Med 162:1985-1993, 2002) and Edwards et al. (Cancer 97:1407-1427, 2005). Numerous barriers such as cultural beliefs, fear, fatalism, mistrust, stigma, and lack of culturally appropriate interventions could contribute to low cancer screening …


The Role Of Vsmc Mir-33a Expression On Apoa-I Mediated Cholesterol Efflux And Macrophage-Like Cell Transdifferentiation, Ikechukwu Esobi Dec 2022

The Role Of Vsmc Mir-33a Expression On Apoa-I Mediated Cholesterol Efflux And Macrophage-Like Cell Transdifferentiation, Ikechukwu Esobi

All Dissertations

Atherosclerosis is a condition caused by cholesterol accumulating in arterial intimal cells and is a disease that kills more people in the United States and globally than any other disease. Atherosclerosis is commonly recognized to arise from arterial intimal macrophage cholesterol accumulation, but cell lineage tracing technology has shown that a large majority of cholesterol-laden intimal cells found in atherosclerotic arteries are actually vascular smooth muscle cells that have switched phenotypes to a macrophage-like cell. This vascular smooth muscle cell to macrophage-like cell phenotypic switch is known as transdifferentiation and can be triggered by vascular smooth muscle cell cholesterol accumulation. …


Effect Of Chlorine Dioxide Gas On The Properties Of Packaging Materials And Effect Of Chlorine Dioxide Gas To Maintain The Quality Of Fresh Strawberries, Duleeka Kuruwita, Duleeka Prasadani Kuruwita Arachchige Dec 2022

Effect Of Chlorine Dioxide Gas On The Properties Of Packaging Materials And Effect Of Chlorine Dioxide Gas To Maintain The Quality Of Fresh Strawberries, Duleeka Kuruwita, Duleeka Prasadani Kuruwita Arachchige

All Dissertations

ClO2 as an antimicrobial gas in the headspace of produce package is a relatively novel approach. Gaseous ClO2 is more effective than aqueous ClO2 and can be used in the headspace of fresh food packages. ClO2 gas can diffuse into product surfaces and films. As an oxidizer, it can react with and change polymeric package components, possibly affecting the product’s shelflife.

This research studied effects of ClO2 gas treatments on produce packaging materials (APET, two PE types, Nylon). The treatment group (with ClO2) and the control group (without ClO2) of packaging …


The Role Of Muscle Damage On Joint Tissue, Logan Nicholas Moore Dec 2022

The Role Of Muscle Damage On Joint Tissue, Logan Nicholas Moore

Kinesiology Dissertations - Archive

The musculoskeletal system is a highly diverse network of tissue that operates in conjunction to one other, both mechanically and biochemically. In states of disorder such as musculoskeletal disorders, this cross-communication between tissues is pivotal in the progression of disease state in other tissues, or the prevention and healing of the effected tissue. Musculoskeletal disorders (MSkD) are a broad term encompassing disorders to bones, joints, muscles and connective tissues. These disorders include Osteoarthritis, Osteopenia, Sarcopenia, Tendonitis, Myopathies, and muscle weakness. Osteoarthritis (OA) is the most common joint disorder, characterized as damage to the articulating cartilage and alterations in other joint …


Timing Of Implants Use In Backgrounding System, Kylie M. Butterfield Dec 2022

Timing Of Implants Use In Backgrounding System, Kylie M. Butterfield

Applied Science Program: Theses

A study was conducted over two years to determine the interactions of winter rate of gain at a high gain (HG) of 0.91 kg and low gain (LG) 0.45 kg, and implant strategy in the backgrounding and subsequent effects in the finishing phases. There were three phases in this study, the winter phase (~148 days), the summer phase (~60 days) and the finishing phase (~120 days). This was a 2 x 3 factorial design. The first factor is a rate of gain at either 0.91 kg (HG) or 0.45 kg (LG). The next factor is the timing of implant where …


Quantifying The Relationship Between Soil Organic Carbon And Soil Color In Nebraska, Aldi J. Airori Dec 2022

Quantifying The Relationship Between Soil Organic Carbon And Soil Color In Nebraska, Aldi J. Airori

Applied Science Program: Theses

Soil color is easily measured in the field and holds potential to be used as an indirect measurement of soil organic carbon (SOC). The main limitation to this approach is knowledge about the specific color-SOC relationship in a region, which often varies in relation to parent material, soil texture, climate, and land use. Furthermore, the Munsell color data is subjective in nature. The objectives of this study are: 1) to develop and evaluate the accuracy of pedotransfer functions (PTFs) for the prediction of SOC based on soil color and texture in the state of Nebraska and 2) to evaluate digital …


173rd Commencement, Fall Dec 2022

173rd Commencement, Fall

Commencement Programs

No abstract provided.


Factors Impacting Organ Transplant Outcomes, Katelyn Grubich Dec 2022

Factors Impacting Organ Transplant Outcomes, Katelyn Grubich

Nursing | Senior Theses

Organ transplants are crucial to the survival of those on the receiving end. With medicine advancing, so has transplantation. Health care providers are becoming more aware of the strategies necessary to prolong the transplanted organ and how to obtain better outcomes. Heart, lungs, kidney, liver, pancreas, and some where more than one organ are involved, are the types of organ transplants performed.

Providing patients information will allow them to be a part of their treatment and can help to ease their anxiety knowing what is being performed and what can be expected. Health care providers must ensure that patients and …


Safe Practices For Preventing Covid-19 Among School-Aged Children, Meleena Reyelle Banda-Garcia Dec 2022

Safe Practices For Preventing Covid-19 Among School-Aged Children, Meleena Reyelle Banda-Garcia

Nursing | Senior Theses

Communicable diseases and infections are common health problems among children. Among the most impactful communicable diseases present today is COVID-19, a disease caused by a virus named SARS-CoV-2, which has forced many school closures due to rapid transmission. Despite children not being the main driving factor of the spread of the disease, severe complications underlying COVID-19 incidence have resulted in increased hospitalization among school-age children.The initial global response to the spread of COVID-19 included the closure of school systems; however as the disease continues to be effectively managed, communities are starting to re-open schools partially or entirely nationwide. Although pharmaceutical …


Beef Bull Selection And Management Affecting Breeding Season Outcomes For California Cattle Producers On Rangelands, Megan Banwarth Dec 2022

Beef Bull Selection And Management Affecting Breeding Season Outcomes For California Cattle Producers On Rangelands, Megan Banwarth

Master's Theses

California’s approximately 660,000 head of beef cattle are highly dependent on range bulls used to produce offspring that can perform across the state’s diverse ecological regions. While knowledge of bull breeding behavior and the technology used to monitor cattle movement and behavior is critical to maximize conception rates and the overall efficiency in natural service sires on rangelands. Bulls need to be functional on rugged coastal landscapes, rolling foothills, deserts, and in high-elevation terrain. Few data exist that indicate factors related to selection, maintenance, and longevity of bulls used in rangeland landscapes. Objectives herein, were to assess factors influencing bull …


Dietary Protein Intakes, Distribution Patterns, And Quality In Ncaa Divsion 1 Soccer Players, Jun H. Kwon Dec 2022

Dietary Protein Intakes, Distribution Patterns, And Quality In Ncaa Divsion 1 Soccer Players, Jun H. Kwon

Master's Theses

Dietary protein is required to support recovery and adaptation following exercise training. While prior research demonstrates that many athletes meet total daily protein needs, intake seems to be predominantly skewed toward the evening meal. An even distribution of protein doses throughout the course of a day is theorized to confer greater skeletal muscle anabolism compared to a skewed pattern of intake. Protein quality is also an important dietary consideration for athletes, with the amino acid leucine being the primary driver of the postprandial anabolic response. The present thesis investigates the protein consumption characteristics among a selected cohort of NCAA Division …


Mediterranean-Style Diet And Exercise Improve Parameters For Management And Prevention Of Type 2 Diabetes Mellitus, Stefani Ann Derrick Dec 2022

Mediterranean-Style Diet And Exercise Improve Parameters For Management And Prevention Of Type 2 Diabetes Mellitus, Stefani Ann Derrick

Master's Theses

Type 2 diabetes mellitus (T2DM) is a chronic condition recognized as the inability to maintain glucose homeostasis, typically presenting with insulin resistance and systemic inflammation. With the prevalence of T2DM and major risk factors such as prediabetes and obesity increasing each year, there is a crucial need to identify strategies for the management and prevention of this condition. Addressing lifestyle-related risk factors through consumption of a well-balanced, nutritious diet and maintaining regular moderate- to high-intensity physical activity may provide a strategy for improving glycemic control, improving metrics of body composition, and decreasing the inflammatory response associated with metabolic dysregulation. Twenty-two …


International Pooled Patient-Level Meta-Analysis Of Ketamine Infusion For Depression: In Search Of Clinical Moderators, Rebecca B Price, Nicholas Kissel, Andrew Baumeister, Rebecca Rohac, Mary L Woody, Elizabeth D Ballard, Carlos A Zarate, William Deakin, Chadi G Abdallah, Adriana Feder, Dennis S Charney, Michael F Grunebaum, J John Mann, Sanjay J Mathew, Bronagh Gallagher, Declan M Mcloughlin, James W Murrough, Suresh Muthukumaraswamy, Rebecca Mcmillan, Rachael Sumner, George Papakostas, Maurizio Fava, Rebecca Hock, Jennifer L Phillips, Pierre Blier, Paulo Shiroma, Peter Šóš, Tung-Ping Su, Mu-Hong Chen, Mikael Tiger, Johan Lundberg, Samuel T Wilkinson, Meredith L Wallace Dec 2022

International Pooled Patient-Level Meta-Analysis Of Ketamine Infusion For Depression: In Search Of Clinical Moderators, Rebecca B Price, Nicholas Kissel, Andrew Baumeister, Rebecca Rohac, Mary L Woody, Elizabeth D Ballard, Carlos A Zarate, William Deakin, Chadi G Abdallah, Adriana Feder, Dennis S Charney, Michael F Grunebaum, J John Mann, Sanjay J Mathew, Bronagh Gallagher, Declan M Mcloughlin, James W Murrough, Suresh Muthukumaraswamy, Rebecca Mcmillan, Rachael Sumner, George Papakostas, Maurizio Fava, Rebecca Hock, Jennifer L Phillips, Pierre Blier, Paulo Shiroma, Peter Šóš, Tung-Ping Su, Mu-Hong Chen, Mikael Tiger, Johan Lundberg, Samuel T Wilkinson, Meredith L Wallace

Children’s Nutrition Research Center Staff Publications

Depression is disabling and highly prevalent. Intravenous (IV) ketamine displays rapid-onset antidepressant properties, but little is known regarding which patients are most likely to benefit, limiting personalized prescriptions. We identified randomized controlled trials of IV ketamine that recruited individuals with a relevant psychiatric diagnosis (e.g., unipolar or bipolar depression; post-traumatic stress disorder), included one or more control arms, did not provide any other study-administered treatment in conjunction with ketamine (although clinically prescribed concurrent treatments were allowable), and assessed outcome using either the Montgomery-Åsberg Depression Rating Scale or the Hamilton Rating Scale for Depression (HRSD-17). Individual patient-level data for at least …