Digital Commons Network^™

A Systematic Review Of Literature On Occupational Health And Safety Interventions For Older Workers, Tim Bentley, Leigh-Ann Onnis, Alexis Vassiley, Ben Farr-Wharton, Carlo Caponecchia, Catherine Andrew, Sharron O’Neill, Abilio De Almeida Neto, Vanessa Huron, Nicola Green

Research outputs 2022 to 2026

As the global population ages there is an imperative to enhance labour participation of older workers in ways that support good physical and psychological health. However, there is limited guidance for organisations on how to do this effectively. This systematic review examined literature identified through four databases and a targeted web-search, yielding 39 PRISMA records (32 scholarly, seven grey literature) reporting workplace interventions aimed at improving the injury outcomes of older workers. The review revealed that organisational and composite interventions may be most effective, although an absence of robust research in this area and a scarcity of empirical evidence-based interventions …

Three-Dimensional Food Printing: Its Readiness For A Food And Nutrition Insecure World, Liezhou Zhong, Joshua R. Lewis, Marc Sim, Catherine P. Bondonno, Mark L. Wahlqvist, Amin Mugera, Sharon Purchase, Kadambot H. M. Siddique, Michael J. Considine, Stuart K. Johnson, Amanda Devine, Jonathan M. Hodgson

Research outputs 2022 to 2026

Three-dimensional (3D) food printing is a rapidly emerging technology offering unprecedented potential for customised food design and personalised nutrition. Here, we evaluate the technological advances in extrusion-based 3D food printing and its possibilities to promote healthy and sustainable eating. We consider the challenges in implementing the technology in real-world applications. We propose viable applications for 3D food printing in health care, health promotion and food waste upcycling. Finally, we outline future work on 3D food printing in food safety, acceptability and economics, ethics and regulations. . .

Dietary Nitrate Intake In Relation To The Risk Of Dementia And Imaging Markers Of Vascular Brain Health: A Population-Based Study, Tosca O.E. De Crom, Lauren Blekkenhorst, Meike W. Vernooij, M. Kamran Ikram, Trudy Voortman, M. Arfan Ikram

Research outputs 2022 to 2026

Background

Nitric oxide is a free radical that can be produced from dietary nitrate and positively affects cardiovascular health. With cardiovascular health playing an important role in the etiology of dementia, we hypothesized a link between dietary nitrate intake and the risk of dementia.

Objectives

This study aimed to find the association of total, vegetable, and nonvegetable dietary nitrate intake with the risk of dementia and imaging markers of vascular brain health, such as total brain volume, global cerebral perfusion, white matter hyperintensity volume, microbleeds, and lacunar infarcts.

Methods

Between 1990 and 2009, dietary intake was assessed using food-frequency …

Habitual Dietary Nitrate Intake And Cognition In The Australian Imaging, Biomarkers And Lifestyle Study Of Ageing: A Prospective Cohort Study, Anjana Rajendra, Nicola P. Bondonno, Kevin Murray, Liezhou Zhong, Stephanie Rainey-Smith, Samantha Gardener, Lauren Blekkenhorst, David Ames, Paul Maruff, Ralph Martins, Jonathan M. Hodgson, Catherine P. Bondonno, Australian Imaging, Biomarkers And Lifestyle Group

Research outputs 2022 to 2026

Background & aims

Dietary nitrate improves cardiovascular health via a nitric oxide (NO) pathway. NO is key to both cardiovascular and brain health. There is also a strong association between vascular risk factors and brain health. Dietary nitrate intake could therefore be associated with better cognitive function and reduced risk of cognitive decline. This is yet to be investigated. The aim of this study was to investigate the association between habitual intake of dietary nitrate from sources where nitrate is naturally present, and cognitive function, and cognitive decline, in the presence or absence of the apolipoprotein E (APOE) …

Machine Learning For Abdominal Aortic Calcification Assessment From Bone Density Machine-Derived Lateral Spine Images, Naeha Sharif, Syed Zulqarnain Gilani, David Suter, Siobhan Reid, Pawel Szulc, Douglas Kimelman, Mohammad Jafari Jozani, Jonathan M. Hodgson, Marc Sim, Kun Zhu, Nicholas C. Harvey, Douglas P. Kiel, Richard L. Prince, John T. Schousboe, William D. Leslie, Joshua R. Lewis

Research outputs 2022 to 2026

Background

Lateral spine images for vertebral fracture assessment can be easily obtained on modern bone density machines. Abdominal aortic calcification (AAC) can be scored on these images by trained imaging specialists to assess cardiovascular disease risk. However, this process is laborious and requires careful training.

Methods

Training and testing of model performance of the convolutional neural network (CNN) algorithm for automated AAC-24 scoring utilised 5012 lateral spine images (2 manufacturers, 4 models of bone density machines), with trained imaging specialist AAC scores. Validation occurred in a registry-based cohort study of 8565 older men and women with images captured as part …

A Comprehensive Examination Of The Evidence For Whole Of Diet Patterns In Parkinson's Disease: A Scoping Review, Joanna Rees, Jillian Ryan, Manja Laws, Amanda Devine

Research outputs 2022 to 2026

Both motor and non-motor symptoms of Parkinson’s disease (PD), a progressive neurological condition, have broad-ranging impacts on nutritional intake and dietary behaviour. Historically studies focused on individual dietary components, but evidence demonstrating ameliorative outcomes with whole-of-diet patterns such as Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) is emerging. These diets provide plenty of antioxidant rich fruits, vegetables, nuts, wholegrains and healthy fats. Paradoxically, the ketogenic diet, high fat and very low carbohydrate, is also proving to be beneficial. Within the PD community, it is well advertised that nutritional intake is associated with disease progression and symptom severity but understandably, …

Ageing Reduces Persistent Inward Current Contribution To Motor Neurone Firing: Potential Mechanisms And The Role Of Exercise, Lucas B. R. Orssatto, Anthony J. Blazevich, Gabriel S. Trajano

Research outputs 2022 to 2026

Nervous system deterioration is a primary driver of age-related motor impairment. The motor neurones, which act as the interface between the central nervous system and the muscles, play a crucial role in amplifying excitatory synaptic input to produce the desired motor neuronal firing output. For this, they utilise their ability to generate persistent (long-lasting) depolarising currents that increase cell excitability, and both amplify and prolong the output activity of motor neurones for a given synaptic input. Modulation of these persistent inward currents (PICs) contributes to the motor neurones’ capacities to attain the required firing frequencies and rapidly modulate them to …

An Integrative Review Of Project Portfolio Management Literature: Thematic Findings On Sustainability Mindset, Assessment, And Integration, Masoud Aghajani, Gesa Ruge, Kam Jugdev

Research outputs 2022 to 2026

Sustainability integration in project portfolio management helps shape strategic, organizational, and project-based contexts. The authors conducted a structured literature review from 2000 to 2021 and developed a novel integrative framework presenting a holistic view highlighting three substantive research themes: sustainability mindset, sustainability assessment, and sustainability integration in project portfolio processes. Noteworthy progress has been made at the strategic and portfolio levels toward framing a sustainability mindset (definition, values, and principles) and developing frameworks/tools for sustainability assessment and project portfolio selection. However, areas for more research include integrating sustainability into project portfolio processes, reporting, and organizational learning for portfolio improvement.

Challenges To Delivering University Health-Based Work-Integrated Learning To Students With A Disability: A Scoping Review, Tanya Lawlis, Tamieka Mawer, Lesley Andrew, Thomas Bevitt

Research outputs 2022 to 2026

Students with disability experience numerous challenges when engaging in Work-Integrated Learning (WIL). Successful WIL requires stakeholder collaboration to provide an equitable and relevant WIL experience. Stakeholder disparity around disclosure, accommodations, poor attitudes, and behaviours result in negative WIL experiences for students with disability. Understanding stakeholder preparedness and capabilities, in particular host organisations, is key to providing equitable WIL opportunities. Searches of five electronic databases (CINAHL, PubMed, Embase/Scopus, A + Education Informit and Web of Science) were conducted. Twenty-one peer-reviewed articles published between 2005 and 2022 were included in the review. Four themes were identified: Disclosure of the disability; University staff …

Considerations For The Consumption Of Vitamin And Mineral Supplements In Athlete Populations, Peter Peeling, Marc Sim, Alannah K. A. Mckay

Research outputs 2022 to 2026

Vitamins and minerals are of fundamental importance to numerous human functions that are essential to optimise athlete performance. Athletes incur a high turnover of key vitamins and minerals and are therefore dependent on sufficient energy intake to replenish nutrient stores. However, many athletes are poor at servicing their energy replenishment needs, especially female athletes, and although a ‘food first approach’ to meeting nutrient requirements is the primary goal, it may be important for some athletes to consider a vitamin and/or mineral supplement to meet their daily needs. When working to determine if an athlete requires vitamin or mineral supplements, practitioners …

Corrigendum: Evolution, Ecology, And Zoonotic Transmission Of Betacoronaviruses: A Review, Herbert F. Jelinek, Mira Mousa, Eman Alefishat, Wael Osman, Ian Spence, Dengpan Bu, Samuel F. Feng, Jason Byrd, Paola A. Magni, Shafi Sahibzada, Guan K. Tay, Habiba S. Alsafar

Research outputs 2022 to 2026

In the published article, there was an error in the legend for Figure 1 as published. The figure legend did not indicate that it has been adapted from Plowright et al. (2017). Copyright permission was obtained from Springer Nature to adapt Figure 1 from Plowright et al. (2017). The corrected legend appears below. Figure 1. Zoonotic risk distribution, pathway to spillover, and the multimodal role of the determinants of spillover. The zoonotic risk is demonstrated by the accumulated distribution of reservoir hosts and vectors that play a role in the pathway to spillover. The risk of spillover is determined by …

Are We Levelling The Playing Field? A Qualitative Case Study Of The Awareness, Uptake And Relevance Of The Ioc Consensus Statements In Two Countries, Lauren V. Fortington, Marelise Badenhorst, Caroline Bolling, Wayne Derman, Carolyn A. Emery, Kati Pasanen, Martin Schwellnus, Evert Verhagen, Caroline F. Finch

Research outputs 2022 to 2026

Objectives: Research evidence is commonly compiled into expert-informed consensus guidelines intended to consolidate and distribute sports medicine knowledge. Between 2003 and 2018, 27 International Olympic Committee (IOC) consensus statements were produced. This study explored the policy and practice impact of the IOC Statements on athlete health and medical team management in two economically and contextually diverse countries. Methods: A qualitative case study design was adopted. Fourteen face-to-face interviews were conducted with purposively selected interviewees, seven participants from Australia (higher economic equality) and seven from South Africa (lower economic equality), representing their national medical commissions (doctors and physiotherapists of Olympic, Paralympic …

The Effect Of Regular Consumption Of Reformulated Breads On Glycemic Control: A Systematic Review And Meta-Analysis Of Randomized Clinical Trials, Alena M. Schadow, Ingrid Revheim, Ulrike Spielau, Jutta Dierkes, Lukas Schwingshackl, Jan Frank, Jonathan M. Hodgson, André Moreira-Rosário, Chris J. Seal, Anette E. Buyken, Hanne Rosendahl-Riise

Research outputs 2022 to 2026

Bread is a major source of grain-derived carbohydrates worldwide. High intakes of refined grains, low in dietary fiber and high in glycemic index, are linked with increased risk for type 2 diabetes mellitus (T2DM) and other chronic diseases. Hence, improvements in the composition of bread could influence population health. This systematic review evaluated the effect of regular consumption of reformulated breads on glycemic control among healthy adults, adults at cardiometabolic risk or with manifest T2DM. A literature search was performed using MEDLINE, Embase, Web of Science and the Cochrane Central Register of Controlled Trials. Eligible studies employed a bread intervention …

Feasibility Of Supervised Telehealth Exercise For Patients With Advanced Melanoma Receiving Checkpoint Inhibitor Therapy, Brendan J. Crosby, Robert U. Newton, Daniel A. Galvão, Dennis R. Taaffe, Pedro Lopez Da Cruz, Tarek M. Meniawy, Muhammad A. Khattak, Wei-Sen Lam, Elin S. Gray, Favil Singh

Research outputs 2022 to 2026

Purpose: To determine the feasibility, safety and preliminary efficacy of a telehealth supervised exercise programme in patients with advanced melanoma receiving checkpoint inhibitor therapy. Methods: A 8-week non-randomised feasibility pilot trial utilising a telehealth delivered multimodal exercise programme undertaken thrice weekly with assessments at baseline and post-intervention. The study was considered feasible if there were no severe or life-threatening adverse events as a result of exercise, and three or more of the following criteria were met: the recruitment rate was > 50%, completion rate was > 80%, median programme attendance was > 75%, median exercise compliance > 75%, and average tolerance was > 70%. Preliminary …

Dosing And Therapeutic Conduct In Administration Sessions In Substance-Assisted Psychotherapy: A Systematized Review, S. B. Thal, M. Wieberneit, J. M. Sharbanee, P. M. Skeffington, R. Bruno, T. Wenge, Stephen J. Bright

Research outputs 2022 to 2026

While the potential of serotonergic psychedelics and related substances as adjuncts in substance-assisted psychotherapy (SAPT) has been investigated for the treatment of several disorders, evidence for the appropriate therapeutic conduct in administration sessions is sparse. In this article, we discuss the current evidence for best therapeutic practice during administration sessions with serotonergic psychedelics and entactogens as adjuncts to psychotherapy. We conducted a systematized review of the literature following PRISMA guidelines. PsycINFO, MEDLINE, and Cochrane Library databases were searched. Clinical trials, treatment manuals, study protocols, qualitative studies, case studies, descriptive studies, opinion papers, reviews, book chapters, and conference proceedings published until …

Hand Hygiene Knowledge And Demonstrated Technique Among Malawian Kindergarten Children: A Quasi-Experimental Study, Balwani Chingatichifwe Mbakaya, Maggie Zgambo, Fatch Welcome Kalembo

Research outputs 2022 to 2026

Aim: To evaluate hand hygiene knowledge and demonstrated technique before and after implementation of the hand hygiene programme and its sustainability among Malawian kindergarten students. Design: Quasi-experimental design, utilizing a repeated measure at three points, namely, before intervention (T0), soon after intervention (T1) and follow-up (T2). Methods: The hand hygiene programme consisted of integrating hand hygiene protocol into the school health curriculum, setting up proper handwashing facilities, training school teachers, health talks and developing reminders on hand hygiene. Fifty-three kindergarten children aged 3–6 years were enrolled in the programme. Data were collected at 3 months' intervals (T0, T1, and T2). …

Impaired Muscle Function, Including Its Decline, Is Related To Greater Long-Term Late-Life Dementia Risk In Older Women, Simone Radavelli-Bagatini, Helen Macpherson, David Scott, Robin M. Daly, Jonathan M. Hodgson, Simon M. Laws, Kun Zhu, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Background: Impaired muscle function has been identified as a risk factor for declining cognitive function and cardiovascular health, both of which are risk factors for late-life dementia (after 80 years of age). We examined whether hand grip strength and timed-up-and-go (TUG) performance, including their change over 5 years, were associated with late-life dementia events in older women and whether any associations provided independent information to Apolipoprotein E ℇ4 (APOE ℇ4) genotype. Methods: Grip strength and TUG were assessed in community-dwelling older women (mean ± SD; age 75.0 ± 2.6 years) at baseline (n = 1225) and 5 years (n = …

Toddlers May Be Getting Enough Iron In Long Day-Care Services After All, Michaela Johnston, Therese O'Sullivan, Amanda Devine, Ruth Wallace, Leesa Costello, Ros Sambell

Research outputs 2022 to 2026

Background: Previous research has suggested that toddlers are not provided with adequate dietary iron in long-day care (LDC) services. However, the iron bioavailability provided is unknown. The present study aimed to investigate the amount and bioavailability of iron provided to toddlers aged 2–3 years at LDC services. Methods: A cross-sectional audit was conducted using a 2-day weighed food record of 30 LDC services. Iron provision (not child intake) in LDC services across Perth, Australia was compared with the estimated average requirements (EAR) and LDC services provision guidelines (50% of EAR = 2 mg/day based on a 14% bioavailability factor). Bioavailability …

A Feasibility, Safety, And Efficacy Evaluation Of Supervised Aerobic And Resistance Exercise For Patients With Glioblastoma Undertaking Adjuvant Chemoradiotherapy, Anna K. Nowak, Robert U. Newton, Travis Cruickshank, Prue Cormie, Georgia K. Halkett, Daphne Tsoi, Daniel A. Galvao

Research outputs 2022 to 2026

Background: While therapeutically effective, chemoradiotherapy treatment for high-grade glioma (glioblastoma) is often accompanied by side effects. Exercise has been demonstrated to alleviate the adverse effects of such treatments in other cancers. We aimed to evaluate the feasibility and preliminary efficacy of supervised exercise incorporating autoregulation. Methods: Thirty glioblastoma patients were recruited, five declined exercise and 25 were provided with a multimodal exercise intervention for the duration of their chemoradiotherapy treatment. Patient recruitment, retention, adherence to training sessions and safety were evaluated throughout the study. Physical function, body composition, fatigue, sleep quality, and quality of life were evaluated before and after …

Barriers And Enablers Associated With Participation In A Home-Based Pragmatic Exercise Snacking Program In Older Adults Delivered And Monitored By Amazon Alexa: A Qualitative Study, Paul Jansons, Jackson J. Fyfe, Jack Dalla Via, Robin M. Daly, David Scott

Research outputs 2022 to 2026

Background: ‘Exercise snacking’, which is characterised by shorter and more frequent exercise bouts compared with traditional exercise guidelines, may be an acceptable strategy for increasing physical activity and reducing sedentary behaviour in older adults. Aim: The aim of this study was to evaluate the enablers and barriers for older adults associated with participation in a home-based exercise snacking program delivered and monitored using an Amazon Echo Show 5 device (Alexa). Methods: This study used an interpretive description qualitative design to conduct semi-structured interviews following a 12-week pilot study in 15 adults aged 60–89 years with at least one chronic condition. …

Policy Challenges And Responses To Environmental Non-Migration, Mostafa Mahmud Naser, Bishawjit Mallick, Rup Priodarshini, Saleemul Huq, Ajay Bailey

Research outputs 2022 to 2026

The scientific literature, media, international summits, and policy forums highlighted enough the people who either move or are willing to move because of environmental reasons. Still, the voluntary environmental non-migrants (ENM), who are assumed to have strong resilience and coping capacity, are inordinately overlooked. The importance of addressing these ENMs has increasingly been emphasised. First, the paper explains the characteristics of ENM, outlining the key distinction between voluntary and forced non-migrants. Second, it emphasises the need to protect populations affected by environmental change and disaster, specifically highlighting oft-neglected ENM policy gaps. Thus, it examines to what extent ENM is addressed …

The Facilitators And Barriers To Exercise In The Noongar Aboriginal Population In Perth, Australia, Tuguy Esgin, Deborah Hersh, Kevin Rowley, Rona Macniven, Alan Crouch, Mark Halaki, Robert Newton

Research outputs 2022 to 2026

Indigenous Standpoint Theory forms the epistemological foundation for this study and methodological choices were made within this theoretical framework to ensure culturally responsive research processes that engaged the Indigenous agenda of self-determination and rights. The objectives of this research were to determine: (i) Indigenous perceptions of the facilitators and barriers to exercise; (ii) The potential feasibility and sustainability of an exercise intervention. In this context, Participatory Action Research methods were used to design the data-gathering instrument for the study—a questionnaire, co-designed with the Noongar Aboriginal community of Perth, Western Australia. This self-administered questionnaire, distributed to participants by email, post and …

Summary Of Gynaecological Cancer Among Aboriginal And/Or Torres Strait Islander People In Australia, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

This publication, in plain language, is based on information presented in the Review of gynaecological cancer among Aboriginal and/or Torres Strait Islander people in Australia (2023). This short, visual report summarises the key findings and concepts from the review to provide a holistic picture of gynaecological cancer among Aboriginal and/or Torres Strait Islander women. It is a quick source of information covering:

• the social, cultural and historical contexts that contribute to inequitable gynaecological cancer rates among Aboriginal and/or Torres Strait Islander women
• the extent of gynaecological cancer, specifically cervical cancer, ovarian cancer and uterine cancer, including the incidence, mortality, …

The Effect Of High-Speed Power Training On Physical Frailty In Older Adults: Effect Of A Visual-Guided Exercise Program In South Korean Rural Areas, Dong H. Yoon, Jin-Soo Kim, Su S. Hwang, Dong W. Lee, Wook Song

Research outputs 2022 to 2026

Objective. Exercise has been shown to be an effective intervention; the difficulty still lies in providing exercise programs to the older adults in rural areas. Therefore, this study aimed to examine the effects of a 12-week exercise program provided with visual guidelines (prerecorded video) on frailty among older adults in rural areas. Methods. Fifty participants (71.7 ± 4.9 years) from 5 different rural areas were recruited and divided into two groups: the exercise group (EX, n = 24 (male: 8, female: 18)) and the control group (CON, n = 26 (male: 7, female: 17)). With the commencement of the exercise …

Vitamin K-1 Intake And Incident Diabetes In The Danish Diet, Cancer, And Health Study, Pratik Pokharel, Jamie W. Bellinge, Frederik Dalgaard, Kevin Murray, Marc Sim, Bu B. Yeap, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Gunnar Gislason, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Carl Schultz, Nicola P. Bondonno

Research outputs 2022 to 2026

Context: Observational studies have reported lower risks of type 2 diabetes with higher vitamin K1 intake, but these studies overlook effect modification due to known diabetes risk factors. Objective: To identify subgroups that might benefit from vitamin K1 intake, we examined associations between vitamin K1 intake and incident diabetes overall and in subpopulations at risk of diabetes. Methods: Participants from the prospective cohort, the Danish Diet, Cancer, and Health Study, with no history of diabetes were followed up for diabetes incidence. The association between intake of vitamin K1, estimated from a food frequency questionnaire completed at baseline, and incident diabetes …

Improving The Quality Of Set Yoghurt Using Milk Fat Globule Membrane Fragments, Joshua Ibitoye, T. T. Q. Phan, Duy N. Le, K. Dewettinck, Michelle L. Colgrave, A. P. Trzcinski, B. Ly-Nguyen

Research outputs 2022 to 2026

Lacprodan PL20, a dairy ingredient that is rich in protein and polar lipids, was added into set yoghurts produced from nonhomogenized raw milk. The set yoghurts were prepared using concentrations of 2%, 4%, and 6% Lacprodan PL20, while the control sample was only supplemented with skim milk powder. The effect of Lacprodan PL20 concentrations on the physical and chemical properties, rheology, and microstructure of set yoghurt was thoroughly investigated to determine some likely improvement or changes in quality. Consequently, Lacprodan PL20 showed a gradual improvement in the set yoghurt nutritive values, water holding capacity, and apparent viscosity. The results indicated …

Working Together To Increase Australian Children’S Liking Of Vegetables: A Position Statement By The Vegetable Intake Strategic Alliance (Visa), David N. Cox, Karen J. Campbell, Lynne Cobiac, Claire Gardner, Lucinda Hancock, Gilly Hendrie, Amber Kelaart, Michelle Lausen, Astrid Poelman, Ros Sambell, Kim M. Tikellis, Bonnie Wiggins

Research outputs 2022 to 2026

Children need to be repeatedly and consistently exposed to a variety of vegetables from an early age to achieve an increase in vegetable intake. A focus on enjoyment and learning to like eating vegetables at an early age is critical to forming favourable lifelong eating habits. Coordinated work is needed to ensure vegetables are available and promoted in a range of settings, using evidence-based initiatives, to create an environment that will support children’s acceptance of vegetables. This will help to facilitate increased intake, and ultimately realise the associated health benefits. The challenges and evidence base for a new approach are …

Unrecognized Hypertension Among A General Adult Ghanaian Population: An Urban Community-Based Cross-Sectional Study Of Prevalence And Putative Risk Factors Of Lifestyle And Obesity Indices, Enoch O. Anto, Wina I. O. Boadu, Emmanuel E. Korsah, Ezkiel Ansah, Eric Adua, Joseph Frimpong, Patience Nyarkoa, Valentine C. K. T. Tamakloe, Emmanuel Acheampong, Evans A. Asamoah, Stephen Opoku, Ebenezer Afrifa-Yamoah, Max E. Annani-Akollor, Christian Obirikorang

Research outputs 2022 to 2026

Hypertension (HTN) is the leading cause of cardiovascular diseases. Nevertheless, most individuals in developing countries are unaware of their blood pressure status. We determined the prevalence of unrecognized hypertension and its association with lifestyle factors and new obesity indices among the adult population. This community-based study was conducted among 1288 apparently healthy adults aged 18–80 years in the Ablekuma North Municipality, Ghana. Sociodemographic, lifestyle characteristics, blood pressure and anthropometric indices were obtained. The prevalence of unrecognized HTN was 18.4% (237 / 1288). The age groups 45–54 years [aOR = 2.29, 95% CI (1.33–3.95), p = 0.003] and 55–79 years [aOR …

A Potential Role For Sirtuin-1 In Alzheimer's Disease: Reviewing The Biological And Environmental Evidence, Mehrane Mehramiz, Tenielle Porter, Eleanor K. O'Brien, Stephanie R. Rainey-Smith, Simon M. Laws

Research outputs 2022 to 2026

Sirtuin-1 (Sirt1), encoded by the SIRT1 gene, is a conserved Nicotinamide adenine dinucleotide (NAD+) dependent deacetylase enzyme, considered as the master regulator of metabolism in humans. Sirt1 contributes to a wide range of biological pathways via several mechanisms influenced by lifestyle, such as diet and exercise. The importance of a healthy lifestyle is of relevance to highly prevalent modern chronic diseases, such as Alzheimer's disease (AD). There is growing evidence at multiple levels for a role of Sirt1/SIRT1 in AD pathological mechanisms. As such, this review will explore the relevance of Sirt1 to AD pathological mechanisms, by describing the involvement …

Measuring Success: Program Fidelity Of Queensland's Child Health Home Visiting Services. A Document Analysis, Nicole Latham, Jeanine Young, Josephine Wilson, Michelle Gray

Research outputs 2022 to 2026

Background: The Family CA.R.E. (Community-based Assistance Resourcing and Education) program was introduced in Queensland two decades ago. It aimed to redress health inequalities for infants from families experiencing specific social stressors. The program has been locally adapted over time and has not been evaluated against the original program. This study assessed the extent to which selected hospital and health services in Queensland, Australia have modified the original Family C.A.R.E. program. Methods: Altheide's model was used to facilitate a critical document analysis of policies and guidelines for adapted Family C.A.R.E. home visiting programs in use by hospital and health services (target …