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Research Progress On The Effect Of Lactic Acid Bacteria On The Flavor Of Fermented Vegetables, Hou Xiao-Yi, Wang Jian-Hui, Deng Na, Li Hui, Zhang Bo, Cai Yong-Jian Jun 2023

Research Progress On The Effect Of Lactic Acid Bacteria On The Flavor Of Fermented Vegetables, Hou Xiao-Yi, Wang Jian-Hui, Deng Na, Li Hui, Zhang Bo, Cai Yong-Jian

Food and Machinery

In the process of vegetable fermentation, the variety and quantity of microorganisms are complex and changeable. Lactic acid bacteria (LAB), as the main power in the process of vegetable fermentation, participate in the regulation of various metabolic pathways and affect the formation of flavor. In this review, the changes of major flavor metabolites during vegetable fermentation and their internal relationship with the community structure and abundance of LAB were summarized, then the potential mechanism of LAB fermentation to produce flavor substances was discussed. Moreover, the application of LAB in vegetable fermentation was prospected.


A Scoping Review Of The Relation Between Toothbrushing And Diabetes Knowledge, Glycemic Control, And Oral Health Outcomes In People With Type 2 Diabetes, Ruth D. Lipman, Kelly K. O'Brien, Joan K. Bardsley, Michelle F. Magee Jun 2023

A Scoping Review Of The Relation Between Toothbrushing And Diabetes Knowledge, Glycemic Control, And Oral Health Outcomes In People With Type 2 Diabetes, Ruth D. Lipman, Kelly K. O'Brien, Joan K. Bardsley, Michelle F. Magee

Individual Scholarship

Objective

Given the bidirectional relationship between type 2 diabetes and periodontal disease, this study sought to compile the available data regarding the relationship between home oral hygiene, specifically toothbrushing, and glycemic control and oral health in people with type 2 diabetes. Methods

A systematic scoping review was conducted using a combination of controlled vocabulary and keyword terms for type 2 diabetes and home oral care in PubMed and CINHAL. Publications from the past 20 years were considered for inclusion. Study data were summarized. Results

A total of 11 studies met our inclusion criteria. In all survey research identified, self-report of …


Implementation Of A Virtual Interprofessional Icu Learning Collaborative: Successes, Challenges, And Initial Reactions From The Structured Team- Based Optimal Patient-Centered Care For Virus Covid-19 Collaborators, Simon Zec, Nika Zorko Garbajs, Yue Dong, Ognjen Gajic, Christina Kordik, Lori Harmon, Marija Bogojevic, Romil Singh, Yuqiang Sun, Vikas Bansal, Linh Vu, Kelly Cawcutt, John M. Litell, Sarah Redmond, Elly Fitzpatrick, Kirstin J. Kooda, Michelle Biehl, Neha S. Dangayach, Viren Kaul, June M. Chae, Aaron Leppin, Mathew Siuba, Rahul Kashyap, Allan J. Walkey, Alexander S. Niven Jun 2023

Implementation Of A Virtual Interprofessional Icu Learning Collaborative: Successes, Challenges, And Initial Reactions From The Structured Team- Based Optimal Patient-Centered Care For Virus Covid-19 Collaborators, Simon Zec, Nika Zorko Garbajs, Yue Dong, Ognjen Gajic, Christina Kordik, Lori Harmon, Marija Bogojevic, Romil Singh, Yuqiang Sun, Vikas Bansal, Linh Vu, Kelly Cawcutt, John M. Litell, Sarah Redmond, Elly Fitzpatrick, Kirstin J. Kooda, Michelle Biehl, Neha S. Dangayach, Viren Kaul, June M. Chae, Aaron Leppin, Mathew Siuba, Rahul Kashyap, Allan J. Walkey, Alexander S. Niven

Jefferson Hospital Staff Papers and Presentations

IMPORTANCE: Initial Society of Critical Care Medicine Discovery Viral Infection and Respiratory illness Universal Study (VIRUS) Registry analysis suggested that improvements in critical care processes offered the greatest modifiable opportunity to improve critically ill COVID-19 patient outcomes. OBJECTIVES: The Structured Team-based Optimal Patient-Centered Care for Virus COVID-19 ICU Collaborative was created to identify and speed implementation of best evidence based COVID-19 practices. DESIGN, SETTING, AND PARTICIPANTS: This 6-month project included volunteer interprofessional teams from VIRUS Registry sites, who received online training on the Checklist for Early Recognition and Treatment of Acute Illness and iNjury approach, a structured and systematic method …


Effects Of Different Microwave Drying Conditions On Drying Characteristics And Quality Of Preserved Apricots, Zhao Hong-Xia, Wang Ying-Qiang, Ma Yu-He, Liu Ye-Rong, Wen Jian-Hua, Zhang Bian-Fei Jun 2023

Effects Of Different Microwave Drying Conditions On Drying Characteristics And Quality Of Preserved Apricots, Zhao Hong-Xia, Wang Ying-Qiang, Ma Yu-He, Liu Ye-Rong, Wen Jian-Hua, Zhang Bian-Fei

Food and Machinery

Objective: This study aimed to improve the drying efficiency and product quality of preserved apricot. Methods: The preserved apricots were dried using the rotary microwave oven (RMD) and the microwave coupled with convection dryer (MCD). The effect of microwave power, microwave emission mode, cutting and material movement on drying characteristics, the scorching rate, color and sensory quality were investigated and compared with traditional hot air drying (HD). Results: Compared with 1 040 min (16 pieces) and 840 min (48 pieces) of HD, the drying time was significantly shortened by microwave drying, ranging from 40 to 400 min. The drying time …


Telehealth Implementation At A Spinal Cord Injury Clinic Within One Veteran Affairs Medical Center In Pennsylvania, Kristina Tait Jun 2023

Telehealth Implementation At A Spinal Cord Injury Clinic Within One Veteran Affairs Medical Center In Pennsylvania, Kristina Tait

Dissertations

Patients with a spinal cord injury (SCI) often require follow-up care from a specialized provider to help reduce complications. The project sited noted that poor follow-up attendance was due to the distance the patients were from the specialty site and sought an evidence-based approach to manage follow-ups. The purpose of this quantitative, quasi-experimental quality improvement project was to determine if the implementation of the American Academy of Family Physicians (AAFP) A Toolkit for Building and Growing a Sustainable Telehealth Program in Your Practice would improve attendance rates for follow-up appointments among SCI patients.


Research Progress On The Influence Of Protein On Physicochemical Properties, Microstructures And Digestive Properties Of Starch And Its Application, Zhao Hai-Bo, Sun Chun-Rui, Qiu Hong-Wei, Cui Bo, Cheng Yun-Hui, Chen Ling Jun 2023

Research Progress On The Influence Of Protein On Physicochemical Properties, Microstructures And Digestive Properties Of Starch And Its Application, Zhao Hai-Bo, Sun Chun-Rui, Qiu Hong-Wei, Cui Bo, Cheng Yun-Hui, Chen Ling

Food and Machinery

Starch and protein are two important components in food system. The interactions between starch and protein have important influence on the structure, physicochemical properties of starch and the texture and digestibility of starch-based food. In recent years, the effect of exogenous protein on starch-protein interaction in mixed system and its application have become a hot research topic in the field of food. This article reviews the interaction mode between starch and protein, the effect of protein on physicochemical properties (gelatinization properties, retrogradation properties, rheological properties, thermal properties and texture properties) and microstructure of starch-protein mixed system, summarizes the regulation effect …


Humanitarian Shelter Guidelines: Indonesian Version, Keren Remaliah Karsa, Laksmi Kusuma Wardani Jun 2023

Humanitarian Shelter Guidelines: Indonesian Version, Keren Remaliah Karsa, Laksmi Kusuma Wardani

Smart City

No one can avoid disasters that could happen to anyone, anywhere, and anytime. Disasters might destoy people’s homes which are the primary need of human being. Therefore, people affected by disaster need new shelters to live in. Providing a shelter is not merely building a structure. However, shelter is a process of providing a better place for people especially those who are affected by disasters. Shelters and settlement assistance need to support a secure, dignified, and comfortable life. Ministry of Social Affairs Republic of Indonesia, coordinating with Indonesian Red Cross Society, published the Humanitarian Shelter Guidelines book in Indonesian version. …


Microbiological Safety And Quality Of Ceviche, Poke, And Sushi Dishes Sold At Retail Outlets In Orange County, Ca, Grace E. Marquis, Samantha M. Covaia, Amanda M. Tabb, Courtney J. Kitch, Rosalee S. Hellberg Jun 2023

Microbiological Safety And Quality Of Ceviche, Poke, And Sushi Dishes Sold At Retail Outlets In Orange County, Ca, Grace E. Marquis, Samantha M. Covaia, Amanda M. Tabb, Courtney J. Kitch, Rosalee S. Hellberg

Food Science Faculty Articles and Research

Raw, ready-to-eat (RTE) seafood products, such as ceviche, poke, and sushi, have experienced growing demand globally; however, these products have the potential to be contaminated with foodborne pathogens. The objective of this study was to determine the prevalence of Escherichiacoli/coliforms, Salmonella, and Listeria in ceviche, poke, and sushi dishes sold at the retail level in Orange County, CA, USA. Additional organisms detected during testing were also considered in the results. A total of 105 raw, RTE samples of ceviche, poke, and sushi were collected from restaurants and grocery stores in Orange County, CA. Samples were tested for Salmonella …


Rebuild Relationships Between City, Agriculture And Ecosystem In The World Of The Drought, Ninghao Wang Jun 2023

Rebuild Relationships Between City, Agriculture And Ecosystem In The World Of The Drought, Ninghao Wang

Masters Theses

The drought is a threat to our planet and our way of life, causing serious consequences for both people and the environment. These consequences include crop failures, food shortages, water conflicts, and so on. Arizona is currently at the center of the water crisis affecting the American West. The state depends on the Colorado River for a third of its agricultural and urban water needs. However, the river is shrinking due to drought, leading to water scarcity in the region. Rebuilt Relationships Between Agriculture, Ecosystem, and City in the World of the Drought: rethinking regenerative landscape practices in the drought-prone …


Interstice, Shravan Rao Jun 2023

Interstice, Shravan Rao

Masters Theses

When I was about three years old, I distinctly remember being too small to see what was on top of the table. A couple of years later, when I could see those objects, I thought the world around me had grown smaller. In a way, it did, as I experienced, lived, captured, remembered, and shared the space repeatedly. This sense of the world shrinking was exaggerated during the Covid-19 pandemic, allowing new behaviours and modes of interaction to emerge. Continually shaping our modern lives, virtual technologies redefine how we access and share information and stories or even explore new places. …


Moving In, Moving Up, Moving On : The Adaptation And Preservation Of Chinese Diasporas Through Food, Jieqi Yao Jun 2023

Moving In, Moving Up, Moving On : The Adaptation And Preservation Of Chinese Diasporas Through Food, Jieqi Yao

Masters Theses

Moving In, Moving Up, Moving On explores the processes of Chinese culture and space in America of adaptation, assimilation, and preservation that underlie food changes. As Chinatowns across the US have evolved and residents have relocated, former centers of Chinese cultural identity have progressively transformed into restaurant districts with increasingly diverse populations and space gentrification.

The thesis argues that food is central to preserving cultural memory and reducing the generation divide. In the context of the Chinese diaspora transformation, culture has changed food in different spaces, and it gives people more choices to acquire and exchange information and values through …


Abundance Within Scarcity: Food Security In The Favelas Of Brazil, Menglin Ding Jun 2023

Abundance Within Scarcity: Food Security In The Favelas Of Brazil, Menglin Ding

Masters Theses

Rapid urbanization has been accompanied by the expansion of unplanned, underserved neighborhoods with large concentrations of poor people, known as "informal settlements.” Obtaining stable, fresh, and healthy food sources often requires people to spend more money, which can be a challenge for residents of informal settlements who may struggle to afford it. To create greater food security and decentralized food production, Abundance within Scarcity, Food Security in the Favelas of Brazil explores how urban agriculture can be strategically reintroduced into limited-open-space informal settlements and tap into the abundant potential of this seemingly "barren” region. Finally, this project will build a …


The People's Food Project, Grace Barrett Jun 2023

The People's Food Project, Grace Barrett

Masters Theses

The architectural design of spaces offering food assistance has received little to no attention since food pantries emerged in the 1970s. Non-profit food initiatives are often sited quickly with limited resources, producing inadequate spaces unable to fully support a food insecure community, prioritize the experience of users, and create a sense of belonging. The current spaces limit services to merely food distribution. They do not take advantage of the opportunity to expand socioeconomic capital through the power of shared food experiences: growing, cooking, eating, and learning.

This thesis redefines the traditional food pantry model, responding to explorations in psychological comfort …


The Health Impacts Of The Trump Administration Among California Immigrants, Claudia M. Calhoon Jun 2023

The Health Impacts Of The Trump Administration Among California Immigrants, Claudia M. Calhoon

Dissertations and Theses

Immigration policy was a marquee issue in the US presidential administration of Donald Trump. Trump’s administration employed both policy and rhetoric related to immigrants to mobilize voters, alter immigration policies and practices, and sustain a narrative of a nation under attack by immigrants. Administration officials were able to undertake these approaches because of existing immigration law, but they did so in more explicitly punitive ways than in recent administrations. The goal of this dissertation is to explore the health impacts of the administration’s practices and their effects. Paper 1 analyzes the immigration rhetoric and policies of US president Donald Trump …


Improving Microbiome Research Through Enhanced Reporting And Modeling The Effects Of Antibiotic Usage, Chloe A. Mirzayi Jun 2023

Improving Microbiome Research Through Enhanced Reporting And Modeling The Effects Of Antibiotic Usage, Chloe A. Mirzayi

Dissertations and Theses

I consider two key areas in the growing field of human microbiome research: improving the quality of study reporting and the impact of antibiotics on participants in human gut microbiome research studies. In the first chapter, a team of evaluators used the Strengthening the Organization and Reporting of Microbiome Studies (STORMS) checklist to assess recently published microbiome literature. I found moderate agreement and reliability between evaluators, identified several items in STORMS that could be improved, and confirmed that the STORMS checklist can serve as a tool for assessing the reporting quality of published microbiome study. The next chapter considers pre-exposure …


Freedom Is A Leaky System: Living Together In The Mess, Calgary Haines-Trautman Jun 2023

Freedom Is A Leaky System: Living Together In The Mess, Calgary Haines-Trautman

Masters Theses

Litter is upsetting.

People upset by litter often misunderstand its sources. Those for whom state power has worked look for simple solutions that seek to surveil, fine, and punish culprits.

Reality is messy.

The path of trash from hand to landfill requires a series of successful transfers between receptacles and responsibility. Wind, accidents, and spills in automated systems complicate trash’s path from here to away. Out of this complexity, leaks accumulate—visible issues without clear causes or responsibility.

Leaks are unavoidable.

There is an irreducible gap between the world as it is and our models of it. In this mismatch, …


Illinois Masonic Hospital School Of Nursing Yearbook, 1971, Advocate Aurora Health Jun 2023

Illinois Masonic Hospital School Of Nursing Yearbook, 1971, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Hospital, Chicago, IL: Reflections 1971. Illinois Masonic Hospital School of Nursing Yearbook.


Illinois Masonic Hospital School Of Nursing Yearbook, 1970, Advocate Aurora Health Jun 2023

Illinois Masonic Hospital School Of Nursing Yearbook, 1970, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Hospital, Chicago, IL: Hemispheres 1969. Illinois Masonic Hospital School of Nursing Yearbook.


Examining The Influence Of Access To District Provided Prekindergarten On First Grade Students’ Academic And Social Emotional School Readiness, Jennifer Brooks Jun 2023

Examining The Influence Of Access To District Provided Prekindergarten On First Grade Students’ Academic And Social Emotional School Readiness, Jennifer Brooks

Student Theses and Dissertations

The study explored teachers’ perceptions of how district provided prekindergarten influences academic and social emotional school readiness for first grade students in a low socioeconomic school district in Southern Arkansas. Piaget’s Theory of Cognitive Development and Erikson’s Theory of Psychosocial Development were the guiding theories. A qualitative case study design was employed. Data was collected through two-round interviews with seven teachers who teach first grade students in a low socioeconomic district in south Arkansas. The interview questions were derived from the Arkansas Child Development and Early Learning Standards. The interviews were transcribed and then coded to derive themes. Findings showed …


A Policy Proposal For Agricultural Data Governance, Ana Sofía Castellanos Santamaría Jun 2023

A Policy Proposal For Agricultural Data Governance, Ana Sofía Castellanos Santamaría

Dissertations and Theses

As the digital economy continues to grow and data becomes increasingly important, effective data governance is essential. A data governance framework enables the efficient management, sharing, and integration of data, resulting in better decision-making, increased productivity, and enhanced innovation across industries, including agriculture. However, the agricultural sector in the United States is lagging behind other industries in the adoption of effective data governance practices. Agricultural data governance presents a unique set of challenges due to the wide range of stakeholders involved and the ever-increasing volume of data generated by digital technologies in farming. One key challenge to achieving the benefits …


Evaluation Of Feasibility And Acceptability Of A Web-Based Diabetes Prevention Program (Dpp) For Diabetes Risk Reduction In Chinese Americans In New York City, Ming-Chin Yeh, Wincy Lau, Claire Anselmo Keady, Margrethe Horlyck-Romanovsky, Ho-Jui Tung, Lu Hu, Grace X. Ma, Judith Wylie-Rosett Jun 2023

Evaluation Of Feasibility And Acceptability Of A Web-Based Diabetes Prevention Program (Dpp) For Diabetes Risk Reduction In Chinese Americans In New York City, Ming-Chin Yeh, Wincy Lau, Claire Anselmo Keady, Margrethe Horlyck-Romanovsky, Ho-Jui Tung, Lu Hu, Grace X. Ma, Judith Wylie-Rosett

Health Policy & Community Health: Faculty Publications

Introduction: Intensive lifestyle intervention remains an effective modality to reduce diabetes incidence and delay the progression to type 2 diabetes. The primary aim of this study was to pilot-test the feasibility and acceptability of a culturally and linguistically tailored web-based DPP intervention among Chinese Americans with prediabetes living in New York City.

Methods: Thirteen Chinese American participants with prediabetes were recruited to complete a 1-year web-based Diabetes Prevention Program (DPP) lifestyle intervention. Quantitative and qualitative measures such as retention rate and data collected from web-based questionnaires and focus groups were collected and analyzed to assess study feasibility and …


Long-Term Outcomes Of Bevacizumab And Chemoradiation For Locoregionally Advanced Nasopharyngeal Carcinoma: A Nonrandomized Controlled Trial, Nancy Y. Lee, Jonathan Harris, John Kim, Adam Garden, James Mechalakos, David G. Pfister, Anthony T.C. Chan, Kenneth Hu, A. Dimitrios Colevas, Steven Frank, George Shenouda, Voichita Bar-Ad, John N. Waldron, Paul M. Harari, Adam Raben, Pedro Torres-Saavedra, Quynh-Thu Le Jun 2023

Long-Term Outcomes Of Bevacizumab And Chemoradiation For Locoregionally Advanced Nasopharyngeal Carcinoma: A Nonrandomized Controlled Trial, Nancy Y. Lee, Jonathan Harris, John Kim, Adam Garden, James Mechalakos, David G. Pfister, Anthony T.C. Chan, Kenneth Hu, A. Dimitrios Colevas, Steven Frank, George Shenouda, Voichita Bar-Ad, John N. Waldron, Paul M. Harari, Adam Raben, Pedro Torres-Saavedra, Quynh-Thu Le

Department of Radiation Oncology Faculty Papers

IMPORTANCE: The long-term outcomes associated with adding bevacizumab, a vascular endothelial growth factor inhibitor, to standard chemoradiation have continued to be favorable for a group of patients with locoregionally advanced nasopharyngeal carcinoma (NPC).

OBJECTIVE: To assess long-term toxic effects and clinical outcomes associated with chemotherapy, radiation therapy (RT), and bevacizumab for NPC.

DESIGN, SETTING, AND PARTICIPANTS: This single-arm phase II nonrandomized controlled trial was conducted by the National Cancer Trials Network group and NRG Oncology (formerly Radiation Therapy Oncology Group), with accrual from December 13, 2006, to February 5, 2009, and data analysis from June 26 to July 1, 2019. …


June 2, 2023 Ereporter, University Of Alabama At Birmingham Jun 2023

June 2, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Curated And Harmonized Gut Microbiome 16s Rrna Amplicon Data From Dietary Fiber Intervention Studies In Humans, Genelle R Lunken, Julien Tap, Kelly S Swanson, Maria Ukhanova, Marion Leclerc, Martin Gotteland, Paola Navarrete, Petia Kovatcheva-Datchary, Wendy J Dahl, Jennifer B H Martiny Jun 2023

Curated And Harmonized Gut Microbiome 16s Rrna Amplicon Data From Dietary Fiber Intervention Studies In Humans, Genelle R Lunken, Julien Tap, Kelly S Swanson, Maria Ukhanova, Marion Leclerc, Martin Gotteland, Paola Navarrete, Petia Kovatcheva-Datchary, Wendy J Dahl, Jennifer B H Martiny

Faculty, Staff and Student Publications

Next generation amplicon sequencing has created a plethora of data from human microbiomes. The accessibility to this scientific data and its corresponding metadata is important for its reuse, to allow for new discoveries, verification of published results, and serving as path for reproducibility. Dietary fiber consumption has been associated with a variety of health benefits that are thought to be mediated by gut microbiota. To enable direct comparisons of the response of the gut microbiome to fiber, we obtained 16S rRNA sequencing data and its corresponding metadata from 11 fiber intervention studies for a total of 2,368 samples. We provide …


Investigating Eco-Evolutionary Interactions Between Hosts And Members Of Their Gut Microbiota, Logan A. Sauers Jun 2023

Investigating Eco-Evolutionary Interactions Between Hosts And Members Of Their Gut Microbiota, Logan A. Sauers

Theses and Dissertations

Evolutionary and ecological interactions between hosts and their associated microbial communities, their microbiota, and between members of these communities are vital to understand. Microbial communities are widespread across diverse host taxa and hosts receive a variety of well-documented benefits from their microbial communities. Despite the importance of understanding eco-evolutionary dynamics for colonization outcomes and the benefits these communities provide to their hosts, our current knowledge in this area remains incomplete. For example, we do not know the full extent of coevolution and specific relationships between hosts and microbes, and between the microbes themselves, across host taxa. Questions remain about how …


Curated And Harmonized Gut Microbiome 16s Rrna Amplicon Data From Dietary Fiber Intervention Studies In Humans, Cynthia I. Rodriguez, Ali Keshavarzian, Bruce R. Hamaker, Feitong Liu, Genelle R. Lunken, Heather Rasmussen, Hongwei Zhou, Julien Tap, Kelly S. Swanson, Maria Ukhanova, Marion Leclerc, Martin Gotteland, Paola Navarrete, Petia Kovatcheva-Datchary, Wendy J. Dahl, Jennifer B. H. Martiny Jun 2023

Curated And Harmonized Gut Microbiome 16s Rrna Amplicon Data From Dietary Fiber Intervention Studies In Humans, Cynthia I. Rodriguez, Ali Keshavarzian, Bruce R. Hamaker, Feitong Liu, Genelle R. Lunken, Heather Rasmussen, Hongwei Zhou, Julien Tap, Kelly S. Swanson, Maria Ukhanova, Marion Leclerc, Martin Gotteland, Paola Navarrete, Petia Kovatcheva-Datchary, Wendy J. Dahl, Jennifer B. H. Martiny

Department of Nutrition and Health Sciences: Faculty Publications

Next generation amplicon sequencing has created a plethora of data from human microbiomes. The accessibility to this scientific data and its corresponding metadata is important for its reuse, to allow for new discoveries, verification of published results, and serving as path for reproducibility. Dietary fiber consumption has been associated with a variety of health benefits that are thought to be mediated by gut microbiota. To enable direct comparisons of the response of the gut microbiome to fiber, we obtained 16S rRNA sequencing data and its corresponding metadata from 11 fiber intervention studies for a total of 2,368 samples. We provide …


Genomic Approaches To Enhance Adaptive Plasticity To Cope With Soil Constraints Amidst Climate Change In Wheat, Roopali Bhoite, Yong Han, Alamuru Krishna Chaitanya, Rajeev K. Varshney, Darshan L. Sharma Jun 2023

Genomic Approaches To Enhance Adaptive Plasticity To Cope With Soil Constraints Amidst Climate Change In Wheat, Roopali Bhoite, Yong Han, Alamuru Krishna Chaitanya, Rajeev K. Varshney, Darshan L. Sharma

Grain and Other Field Crops Research Articles

Climate change is varying the availability of resources, soil physicochemical properties, and rainfall events, which collectively determines soil physical and chemical properties. Soil constraints—acidity (pH < 6), salinity (pH ≤ 8.5), sodicity, and dispersion (pH > 8.5)—are major causes of wheat yield loss in arid and semiarid cropping systems. To cope with changing environments, plants employ adaptive strategies such as phenotypic plasticity, a key multifaceted trait, to promote shifts in phenotypes. Adaptive strategies for constrained soils are complex, determined by key functional traits and genotype × environment × management interactions. The understanding of the molecular basis of stress tolerance is particularly challenging for plasticity traits. Advances in sequencing and high-throughput genomics …


Evaluating The Use Of Blood Pressure Polygenic Risk Scores Across Race/Ethnic Background Groups, Nuzulul Kurniansyah, C Charles Gu, Et Al. Jun 2023

Evaluating The Use Of Blood Pressure Polygenic Risk Scores Across Race/Ethnic Background Groups, Nuzulul Kurniansyah, C Charles Gu, Et Al.

2020-Current year OA Pubs

We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, including PRS-CSx. We use datasets from the MGB Biobank, TOPMed study, UK biobank, and from All of Us to train, assess, and validate PRSs in groups defined by self-reported race/ethnic background (Asian, Black, Hispanic/Latino, and White). For both SBP and DBP, the PRS-CSx based PRS, constructed as a weighted sum of PRSs …


Evaluating The Use Of Blood Pressure Polygenic Risk Scores Across Race/Ethnic Background Groups, Nuzulul Kurniansyah, Matthew O Goodman, Alyna T Khan, Jiongming Wang, Elena Feofanova, Kerri L Wiggins, Tanika Kelly, Tali Elfassy, Xiuqing Guo, Walter Palmas, Henry J Lin, Shih-Jen Hwang, Yan Gao, Kendra Young, Gregory L Kinney, Jennifer A Smith, Bing Yu, Simin Liu, Sylvia Wassertheil-Smoller, Joann E Manson, Xiaofeng Zhu, Yii-Der Ida Chen, I-Te Lee, C Charles Gu, Donald M Lloyd-Jones, Sebastian Zöllner, Myriam Fornage, Charles Kooperberg, Adolfo Correa, Bruce M Psaty, Donna K Arnett, Carmen R Isasi, Stephen S Rich, Robert C Kaplan, Susan Redline, Braxton D Mitchell, Nora Franceschini, Daniel Levy, Jerome I Rotter, Alanna C Morrison, Tamar Sofer Jun 2023

Evaluating The Use Of Blood Pressure Polygenic Risk Scores Across Race/Ethnic Background Groups, Nuzulul Kurniansyah, Matthew O Goodman, Alyna T Khan, Jiongming Wang, Elena Feofanova, Kerri L Wiggins, Tanika Kelly, Tali Elfassy, Xiuqing Guo, Walter Palmas, Henry J Lin, Shih-Jen Hwang, Yan Gao, Kendra Young, Gregory L Kinney, Jennifer A Smith, Bing Yu, Simin Liu, Sylvia Wassertheil-Smoller, Joann E Manson, Xiaofeng Zhu, Yii-Der Ida Chen, I-Te Lee, C Charles Gu, Donald M Lloyd-Jones, Sebastian Zöllner, Myriam Fornage, Charles Kooperberg, Adolfo Correa, Bruce M Psaty, Donna K Arnett, Carmen R Isasi, Stephen S Rich, Robert C Kaplan, Susan Redline, Braxton D Mitchell, Nora Franceschini, Daniel Levy, Jerome I Rotter, Alanna C Morrison, Tamar Sofer

Faculty, Staff and Student Publications

We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, including PRS-CSx. We use datasets from the MGB Biobank, TOPMed study, UK biobank, and from All of Us to train, assess, and validate PRSs in groups defined by self-reported race/ethnic background (Asian, Black, Hispanic/Latino, and White). For both SBP and DBP, the PRS-CSx based PRS, constructed as a weighted sum of PRSs …


Machine Learning Reveals Lipidome Remodeling Dynamics In A Mouse Model Of Ovarian Cancer, Samuel G Moore, Ruihong Chen, Murugesan Palaniappan, Jaeyeon Kim, Martin M Matzuk, Facundo M Fernández Jun 2023

Machine Learning Reveals Lipidome Remodeling Dynamics In A Mouse Model Of Ovarian Cancer, Samuel G Moore, Ruihong Chen, Murugesan Palaniappan, Jaeyeon Kim, Martin M Matzuk, Facundo M Fernández

Faculty, Staff and Students Publications

Ovarian cancer (OC) is one of the deadliest cancers affecting the female reproductive system. It may present little or no symptoms at the early stages and typically unspecific symptoms at later stages. High-grade serous ovarian cancer (HGSC) is the subtype responsible for most ovarian cancer deaths. However, very little is known about the metabolic course of this disease, particularly in its early stages. In this longitudinal study, we examined the temporal course of serum lipidome changes using a robust HGSC mouse model and machine learning data analysis. Early progression of HGSC was marked by increased levels of phosphatidylcholines and phosphatidylethanolamines. …