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The Relationship Between Congenital Heart Disease And Infant Mortality In Low- And Middle-Income Countries: A Comprehensive Literature Review, Helen Nneoma Odo Aug 2023

The Relationship Between Congenital Heart Disease And Infant Mortality In Low- And Middle-Income Countries: A Comprehensive Literature Review, Helen Nneoma Odo

Capstone Experience: Master of Public Health

Congenital heart diseases (CHD) are conditions that are present at birth and can affect the structure of an infant’s heart and the way it works. Millions of children are born each year with congenital heart disease yet screening for CHD is not practiced in Low- and Middle-income countries (LMICs). Studies on access to healthcare for infants with congenital heart disease have not kept pace. This literature review centers on the role of congenital heart disease in infant mortality, its burden, incidence and prevalence in LMICs. The databases of PubMed, Google Scholar and Embase were searched and the selected articles for …


Effects Of Hospital Interventions On Maternal Mortality Rates Of African American Women: A Literature Review, Oluwatosin A. Soyege Aug 2023

Effects Of Hospital Interventions On Maternal Mortality Rates Of African American Women: A Literature Review, Oluwatosin A. Soyege

Capstone Experience: Master of Public Health

Maternal mortality is a serious health concern and harms society’s economic, physical, and psychological well-being. It is tragic for the woman’s family and community when a woman passes away during pregnancy, at delivery, or shortly after delivery. Hospital interventions are needed to mitigate the social impact of maternal mortality. In the U.S., several initiatives have been enacted to reduce maternal mortality. Fighting racism would also help African American women’s rates of maternal mortality as they are subject to stigma in everyday contexts, during pregnancy and obtaining healthcare, and when obtaining resources and services during pregnancy. This paper reviews the literature …


Deerfield Fair 4-H Animal Premium Book, Extension Aug 2023

Deerfield Fair 4-H Animal Premium Book, Extension

UNH Cooperative Extension

No abstract provided.


Target Markets For Renaissance Ag's Pasture Box, Chanden C. Westover Aug 2023

Target Markets For Renaissance Ag's Pasture Box, Chanden C. Westover

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Renaissance Ag is an agricultural company that is committed to trying and increase productivity. Using the Pasture Box, they believe they can grow a feed source that uses less water and land than conventional agriculture. To better understand the benefits of their product, they have allowed Utah State University to conduct research on beef cattle by feeding their fodder. This paper will look into this research and its implications. It also explores various target markets and the benefits of targeting them.


Understanding Profitability Of Small-Scale Agriculture In Utah, Amanda Nelson Aug 2023

Understanding Profitability Of Small-Scale Agriculture In Utah, Amanda Nelson

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Small-scale agriculture production has increased in Utah. Utah has lost much of its farmable land due to increased development. The increased development and influx of people has increased the demand for food supply, resulting in many beginning to producing their own food. This increase in individuals producing their own food has inherently increased the number of micro farms within Utah. This increase in the number of small-scale operations has left many wondering if these operations are both profitable and worth the effort it takes to operate them. As such, this paper will analyze the budget for three activities: (1) raising …


Implementing An Integrated Psychology, Social Services, And Pediatric Diabetes Clinic, Joan P. Totka, Jacquelyn Smith, Sandra Brown, Maharaj Singh, Elaine Parton, Dawn Cvecko, Heather Fortin, Peter M. Wolfgram Aug 2023

Implementing An Integrated Psychology, Social Services, And Pediatric Diabetes Clinic, Joan P. Totka, Jacquelyn Smith, Sandra Brown, Maharaj Singh, Elaine Parton, Dawn Cvecko, Heather Fortin, Peter M. Wolfgram

College of Nursing Faculty Research and Publications

Objective:

Integrated behavioral health services are rarely implemented as a shared space practice in pediatric diabetes specialty clinics. This paper outlines the clinical outcomes, lessons learned, facilitators, and barriers for supporting youth with diabetes and behavioral health issues whose hemoglobin A1c (A1c) was higher than the target range and their families.

Methods:

Using the Iowa Model of implementation, we redesigned the “Regular Engagement And Connection for Health” (REACH) program to integrate health psychology and social services in a shared space clinic for monthly or bimonthly diabetes visits (REACH+). This clinic focused on partnering with families, screening for behavioral and social …


Surface-Functionalized Silica Nanocarriers For Mitigating Water Stress In Wheat And Benefiting The Root Microbiome, Anthony Cartwright Aug 2023

Surface-Functionalized Silica Nanocarriers For Mitigating Water Stress In Wheat And Benefiting The Root Microbiome, Anthony Cartwright

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Changes in climate and shifting patterns of drought threaten the growth of important cash crops like wheat. The element silicon serves as a plant nutrient and shows promise for strengthening wheat against drought while remaining safe to both the crop and the positive bacteria that grow on its roots. Silicon can be added to wheat in the form of silicon-dioxide nanoparticles featuring protective coatings made from plant-beneficial nutrients. These nanoparticles can be engineered with high surface area or porous structures allowing them to be loaded with additional nutrients that can be delivered to crops. In a laboratory setting, such nanoparticles …


Consumption Of A Western Diet Enhanced Colitis-Associated Colorectal Cancer And Dysbiosis Of The Fecal Microbiome In Mice Notwithstanding Dietary Intervention Or Fecal Microbiome Transfer, Daphne Michelle Rodriguez Jimenez Aug 2023

Consumption Of A Western Diet Enhanced Colitis-Associated Colorectal Cancer And Dysbiosis Of The Fecal Microbiome In Mice Notwithstanding Dietary Intervention Or Fecal Microbiome Transfer, Daphne Michelle Rodriguez Jimenez

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In a rodent model of inflammation-associated colorectal cancer, consumption of a Western-style diet increases gut inflammation and enhances risk of developing colon tumors. The goal of this dissertation was to understand the contribution of bacteria within the large intestine on colon inflammation and colon tumorigenesis. Two pre-clinical animal studies were performed using two different intervention strategies to shift the microbiome, and potentially gut inflammation and tumor development: 1) an experiment using dietary supplementation with black raspberries, a functional food enriched in bioactive anthocyanins with purported antiinflammatory activity, and 2) an experiment using fecal microbiota transfer from mice fed a healthy …


Investigating Mitochondrial Influence On The Rate Of Anaerobic Glycolysis In An In Vitro Model, Mackenzie Jenna' Taylor Aug 2023

Investigating Mitochondrial Influence On The Rate Of Anaerobic Glycolysis In An In Vitro Model, Mackenzie Jenna' Taylor

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The rate at which the muscle acidifies after an animal is harvested has a profound effect on the quality of the resulting pork. When acidification increases gradually, desirable pork quality characteristics are developed. In contrast, rapid acidification deteriorates pork quality, exemplified by the pale, soft, and exudative (PSE) pork defect. The rate of acidification is determined by the rate of anaerobic metabolism in postmortem muscle. Yet the processes controlling postmortem anaerobic metabolism are not well understood. Recent research suggests that mitochondria, the powerhouse of the cell, may influence this process by competing for substrate (pyruvate) with anaerobic metabolism, thereby reducing …


Antimicrobial Peptides In Transgenic Silkworm Silk, David Jaden Turner Aug 2023

Antimicrobial Peptides In Transgenic Silkworm Silk, David Jaden Turner

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Overview: People in India and China have produced silk textiles for thousands of years. Silk is a biodegradable, biocompatible compound used in the production of clothing, bedding, furniture, industrial materials, and medical applications. Over the last 30 years, research has increasingly investigated silk’s antimicrobial effects and how to augment its natural abilities. Antimicrobial peptides, or AMPs, are also an area of increasing interest as the rise of antibiotic resistance reduces the efficacy of current treatments. This project plans to systematically synthesize a fusion protein that incorporates the beneficial properties of each constituent into commercial silkworms.

Innovation: This project seeks to …


Statistical Graph Quality Analysis Of Utah State University Master Of Science Thesis Reports, Ragan Astle Aug 2023

Statistical Graph Quality Analysis Of Utah State University Master Of Science Thesis Reports, Ragan Astle

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Graphical software packages have become increasingly popular in our modern world, but there are concerns within the statistical visualization field about the default settings provided by these packages, which can make it challenging to create good quality graphs that align with standard graph principles. In this thesis, we investigate whether the quality of graphs from Utah State University (USU) Plan A Master of Science (MS) thesis reports from the years 1930 to 2019 was affected by the rise of graphical software packages. We collected all data stored on the USU Digital Commons website since November 2021 to determine the specific …


Exploring Body Image Related Cognitive Fusion As A Maintenance Mechanism Of Eating Disorder Pathology, Jennifer L. Barney Aug 2023

Exploring Body Image Related Cognitive Fusion As A Maintenance Mechanism Of Eating Disorder Pathology, Jennifer L. Barney

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Eating disorders are serious mental health conditions that can have serious negative effects on a person’s physical and mental well-being. These disorders are typically complex, and individuals are often struggling with one or more comorbid mental health problems, making them difficult to treat. To address this complexity and hopefully improve treatment outcomes for those with eating disorders, psychology research examining individual differences that appear to be related to differential treatment responses is needed. Better understanding how these factors relate to each other can help treatment providers identify the treatment methods most likely to work best for a specific individual based …


A Mechanistic Examination Of Interspecific Competition Between Wild And Domestic Herbivores, Courtney Check Aug 2023

A Mechanistic Examination Of Interspecific Competition Between Wild And Domestic Herbivores, Courtney Check

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Large herbivores, such as mule deer and cattle have similar life histories and likely compete for resources. However, quantifying the extent to which these species compete and the specific resources they compete for has proved challenging. My research examines if cattle influence deer abundance and behavior due to competition for forage, competition for shade, and/or by affecting the predation risk of deer. Using a grid of autonomous trail cameras, I was able to determine if cattle abundance influences local deer abundance in relation to specific resources and habitat features. Using GPS data from collared deer, I was also able to …


The Influence Of Secondary Principals' Perceived Trust Of Assistant Principals And Central Office Supervisors On Principal Self-Efficacy For Instructional Leadership, Cody J. Reutzel Aug 2023

The Influence Of Secondary Principals' Perceived Trust Of Assistant Principals And Central Office Supervisors On Principal Self-Efficacy For Instructional Leadership, Cody J. Reutzel

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Although self-efficacy has been studied widely in education, variables associated with the self-efficacy of principals have received relatively limited attention. The current study investigated the relationship between secondary principals’ perceptions of trust in their assistant principal and central office supervisor and their own self-efficacy for instructional leadership. Surveys were collected from 80 secondary principals. Open-ended questions were utilized to gain greater understanding of the behaviors contributing to principals’ perceptions of trust and feelings of self-efficacy. Data were analyzed using correlation and multiple regression. Quantitative results revealed that no statistically significant relationship is present between trust perceptions in the relationships investigated …


Greater Sage-Grouse Response To Tree Canopy Removal: Habitat Vegetation Composition And Sage-Grouse Use 10–15 Years Post Treatment In The Southern Periphery Of The Species Range, Benjamen Donnelly Aug 2023

Greater Sage-Grouse Response To Tree Canopy Removal: Habitat Vegetation Composition And Sage-Grouse Use 10–15 Years Post Treatment In The Southern Periphery Of The Species Range, Benjamen Donnelly

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Pinyon juniper woodland expansion into Greater sage-grouse (Centrocercus urophasianus, hereafter ‘sage-grouse’) habitat in southern Utah continues to threaten sage-grouse survival. Habitat restoration after pinyo-juniper removal treatment is key to the continued persistence and survival of sage-grouse along the southern edge of their range. Few long-term studies are available that examine sage-grouse use of areas treated to remove pinyon-juniper forests (i.e., ‘restored habitat’). The purpose of this research was to determine if sage-grouse used ‘restored’ areas in the long-term, as a measure of the actual effectiveness of pinyon-juniper woodland control treatments. I compared vegetation composition, shrub height and shrub …


An Evaluation Of Stress Tolerance In Restoration Plant Species In Response To Fire, Drought, And Invasive Plants Through The Lens Of Functional Traits, Adam M. Clifford Aug 2023

An Evaluation Of Stress Tolerance In Restoration Plant Species In Response To Fire, Drought, And Invasive Plants Through The Lens Of Functional Traits, Adam M. Clifford

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Sagebrush communities in the Great Basin face many threats. Cheatgrass, a winter annual from Eurasia, has invaded these communities, increasing wildfire and lowering species diversity. Additionally, climate models project warmer and drier conditions throughout much of the Great Basin, likely increasing drought, cheatgrass invasion, and wildfire. Intact stands of native and introduced perennial grasses have been shown to limit invasion by cheatgrass and restore ecosystem functions. The objective of this research was to identify the functional traits and growth characteristics needed by restoration species to survive periods of drought and to evaluate varieties of commonly used restoration species for establishment, …


Mountain Lion (Puma Concolor) And Feral Horse (Equus Ferus) Interactions: Examining The Influence Of A Non-Native Ungulate On Predator Behavior In A Semi-Arid Environment, Peter C. Iacono Aug 2023

Mountain Lion (Puma Concolor) And Feral Horse (Equus Ferus) Interactions: Examining The Influence Of A Non-Native Ungulate On Predator Behavior In A Semi-Arid Environment, Peter C. Iacono

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A non-native is a species that evolved in one ecosystem and has established within another. Non-native species can thrive in new ecosystems as they can spread quickly, outcompete and replace native species, and disrupt food webs. Domestic horses were brought to North America by Europeans in 1493. They are now found in 11 states across the western United States. Feral horses can negatively impact vegetation, endangered species habitat, compete with native species, and be important prey for mountain lions under certain conditions. But do feral horses affect the food web? Feral horses are managed by large removals to reduce the …


The Influence Of Climate And Landscape On Allocapnia Mohri Distribution In Arkansas, Brianna Leigh Annaratone Aug 2023

The Influence Of Climate And Landscape On Allocapnia Mohri Distribution In Arkansas, Brianna Leigh Annaratone

Graduate Theses and Dissertations

Stoneflies are a globally threatened aquatic insect order. In Arkansas, a diverse group of winter stonefly (Capniidae: Allocapnia) have not been surveyed since the 1980s, likely because species-level identification requires the rarely-collected adult form. Allocapnia mohri, a regional endemic, was previously commonly found in mountainous, intermittent streams from the Ouachita Mountains ecoregion north to the Ozark Highlands, but no species distributional models including land use or climate variables exist to our knowledge. We collected adults from 70 stream reaches from the historic Arkansas range from November to April 2020 and 2021. We modeled distributions using random forest (RF) models populated …


Evaluation Of Heat Stress And Dietary Amino Acid Density On Nutrient And Energy Partitioning In Broilers, Jean-Remi Teyssier Aug 2023

Evaluation Of Heat Stress And Dietary Amino Acid Density On Nutrient And Energy Partitioning In Broilers, Jean-Remi Teyssier

Graduate Theses and Dissertations

The simultaneous increase in the global demand for animal-based protein products and the rise in temperature associated with global warming pose important challenges to the poultry industry. Heat stress (HS) occurs when an animal’s heat production (HP) surpasses its capacity to dissipate heat into the surrounding environment, ultimately leading to reduced feed intake (FI) and negative impacts on performance. A better understanding of bird responses to elevated temperatures is required to propose effective nutritional strategies that mitigate the adverse effects of HS. Therefore, this dissertation aimed to characterize the nutritional and physiological mechanisms explaining the loss in performance and carcass …


Beef And Dairy Substitution Effects Associated With Carbon Labeling And An Information Intervention, Sara Gardner Hedgecock Aug 2023

Beef And Dairy Substitution Effects Associated With Carbon Labeling And An Information Intervention, Sara Gardner Hedgecock

Graduate Theses and Dissertations

Understanding consumer perceptions of carbon emissions in agriculture is a critical step to help increase the sustainability of food consumption. According to the Food and Agriculture Organization of the United Nations, 14.5 percent of all global anthropogenic GHG emissions are estimated to be represented by livestock (FAO), and cattle, raised for beef and milk, are the largest animal species responsible for emissions, comprising over 60 percent of the livestock sector’s emissions. This motivates this study’s analysis of beef and dairy milk products and alternatives. To better understand how consumers may substitute meat and milk products when provided with information about …


Non-Energy Circular Economy Potential Of Rice Husks: A Techno-Eco-Environmental Assessment, Winfred Oppong Yeboah Aug 2023

Non-Energy Circular Economy Potential Of Rice Husks: A Techno-Eco-Environmental Assessment, Winfred Oppong Yeboah

Graduate Theses and Dissertations

The non-energy circular bioeconomy potential of rice husks was examined via sustainability assessments, namely life cycle assessment (LCA), life cycle impact cost assessment (LCICA), and techno-economic assessment (TEA). The study was conducted with three objectives. The first objective was to review previous studies on the non-energy utilization potential of rice husks by the method of meta-analysis. This review followed a systematic approach where research papers were collected following a defined set of criteria. The study revealed 16 key utilization pathways, all of which showed promising results. However, a comprehensive sustainability assessment was lacking in all of the pathways. The second …


The Effect Of Herbal Adaptogen On Feeding-Related Hypothalamic Neuropeptides In Heat-Stressed Broilers, Maryam Afkhami Ardakani Aug 2023

The Effect Of Herbal Adaptogen On Feeding-Related Hypothalamic Neuropeptides In Heat-Stressed Broilers, Maryam Afkhami Ardakani

Graduate Theses and Dissertations

Heat stress is a major issue in the poultry industry, having numerous negative consequences for chicken productivity. Decreasing feed intake is one of these issues, which results in higher mortality and poor growth performance. Moreover, Herbal adaptogens, plant extracts that are also known as stress response modifiers, are metabolic regulators that improve an organism's ability to adapt to environmental stresses and minimize damage from such stressors. Previously, we published data indicating that herbal adaptogen supplementation increased feed intake under heat stress conditions. Therefore, we hypothesized that dietary herbal adaptogen supplementation might exert these effects through alteration of the expression of …


Investigation Of Consumer Freezing Practices, Condition And Duration On Palatability Of Beef, Elizabeth Sue Neal Aug 2023

Investigation Of Consumer Freezing Practices, Condition And Duration On Palatability Of Beef, Elizabeth Sue Neal

Graduate Theses and Dissertations

The objective of these studies was to determine: the impact of extended periods of frozen storage duration and packaging type on palatability traits of cooked beef steaks from two muscles and the impact of freezing type and storage duration on objective and subjective measures of ground beef palatability traits. In study 1, no differences were elicited from any of the possible interactions (P= 0.95) for SSF or CL: package × muscle × freezing duration, package × muscle, package × duration or muscle × duration. However, freezing duration did impact both SSF (P < 0.01) and CL (P < 0.001). Generally, for both SSF and CL steaks that were frozen for 9-months elicited both the highest SSF values as well as the greatest percentage of CL among all treatments. In comparison, EM was impacted by the interaction (P = 0.059) of packaging type  muscle  freezing duration. Samples from OW GM stored for 9-months elicited the highest percentage of EM while fresh OW LL samples resulted in the lowest. Additionally, expressible moisture was impacted by the interaction (P = 0.047) of muscle  freezing duration. Among all treatments, GM steaks that were frozen for 9-months elicited the highest EM values and fresh LL samples the lowest EM values. Contrastingly, there was no significant difference observed in expressible moisture for the interaction (P  0.18) of package type  freezing duration or for the interaction (P = 0.70) of package type  muscle. Generally, fresh OW GM steaks resulted in the greatest concentration of lipid derived volatile compounds such as aldehydes, hydrocarbons and alcohols which contrasted sensory ratings of trained panelists that indicated oxidized and refrigerator-stale ratings increased as storage time increased for OW steaks. In study 2, The interaction of freezer treatment × storage duration impacted gumminess (P = 0.05), a TPA attribute. In greater detail, samples stored in RF for 6-months resulted in the greatest gumminess values (P < 0.001), while those stored in the CF for 12-months elicited the lowest (P < 0.001). Similarly, flavor development was also impacted by the interaction (P = 0.05) of freezer treatment × storage duration. Three lipid derived compounds were of greatest concentration among RF patties stored for 1-month. In contrast, the interaction of freezer treatment × storage duration elicited no impact on consumer ratings, SF or TBARS. Nonetheless, frozen storage duration impacted TPA, flavor development, consumer ratings, SF and TBARS as a main effect (P < 0.05), especially in regard to tenderness and juiciness. Moreover, beef flavor development, tenderness and juiciness are impacted by freezing duration, muscle, freezer type and packaging, however these factors are not necessarily independent of one another. Furthermore, the retail display period is a critical period for fresh beef steaks, especially when packaged in aerobic conditions. For optimal eating experience, beef products should be stored for extended periods in a vacuum packaging, in a designated freezer that is not opened frequently to allow for optimal air flow regulation and minimize freezer burn to improve tenderness and juiciness.


Use Of Microorganisms For The Enrichment Of Zn And Se By Using Solid-State Fermentation, Rashmi Rangaswamaiah Aug 2023

Use Of Microorganisms For The Enrichment Of Zn And Se By Using Solid-State Fermentation, Rashmi Rangaswamaiah

Graduate Theses and Dissertations

Zinc (Zn) and selenium (Se) are essential minerals for human health and naturally found in many food sources. However, the risk of Zn and Se deficiency has been recognized in several countries. As most people throughout the world consume rice, grains, and cereals as staple foods in their daily diet, which contain a certain amount of phytic acid (antinutrients), the phytic acid content inhibits mineral absorption (Zn and Se) by the human body. Moreover, the low levels of Zn and Se content found in the crop's soil also reduce the amount of minerals in the food sources. Therefore, it is …


Identification And Assessment Of Lameness In Sows Through The Utilization Of NuTrack And Gaitfour Systems, Lexi M. Ostrand Aug 2023

Identification And Assessment Of Lameness In Sows Through The Utilization Of NuTrack And Gaitfour Systems, Lexi M. Ostrand

Department of Animal Science: Dissertations, Theses, and Student Research

Lameness is a financial concern for producers and a welfare concern for the animals. Utilizing both the GAITFour and NUtrack systems, gilts’ natural tendencies and gait were analyzed to better understand the onset of lameness and what indicators can be identified in a commercial setting. Beginning at 20 weeks of age, video on replacement gilts was collected for 9 consecutive days and processed using the NUtrack System to identify individual gilts’ distance travelled (m), avg speed (m/s), angle rotated (degrees), and time standing (s), sitting (s), eating (s), and laying (s). NUtrack is a deep learning-based multi-object …


Consequences Of Cow–Calf Production With Limited Perennial Forage Grazing, Hannah Fae Speer Aug 2023

Consequences Of Cow–Calf Production With Limited Perennial Forage Grazing, Hannah Fae Speer

Department of Animal Science: Dissertations, Theses, and Student Research

Conversion of perennial grasslands to cropland and rising land prices prompts a need to evaluate alternative beef cow-calf production systems. A 3-yr study was conducted comparing beef cow-calf performance between two August-calving cow systems: perennial forage and corn residue grazing; or summer drylot, fall grazing of late-summer-planted cover crop, and corn residue grazing. Cow body condition score differed between systems, but condition of cows in both systems never fell below adequate. There were no differences in pregnancy rates between systems. Calf weaning weights differed between systems each year; differences are attributed to feedstuff quantity, quality, and type available to calves …


Analysis Of Genomic And Immune Intratumor Heterogeneity In Linitis Plastica Via Multiregional Exome And T-Cell Receptor Sequencing, Jin Huang, Guofeng Zhao, Qiu Peng, Xin Yi, Liyan Ji, Jing Li, Pansong Li, Yanfang Guan, Jie Ge, Ling Chen, Runzhe Chen, Xin Hu, Won-Chul Lee, Alexandre Reuben, P Andrew Futreal, Xuefeng Xia, Jian Ma, Jianjun Zhang, Zihua Chen Aug 2023

Analysis Of Genomic And Immune Intratumor Heterogeneity In Linitis Plastica Via Multiregional Exome And T-Cell Receptor Sequencing, Jin Huang, Guofeng Zhao, Qiu Peng, Xin Yi, Liyan Ji, Jing Li, Pansong Li, Yanfang Guan, Jie Ge, Ling Chen, Runzhe Chen, Xin Hu, Won-Chul Lee, Alexandre Reuben, P Andrew Futreal, Xuefeng Xia, Jian Ma, Jianjun Zhang, Zihua Chen

Faculty, Staff and Student Publications

The molecular landscape and the intratumor heterogeneity (ITH) architecture of gastric linitis plastica (LP) are poorly understood. We performed whole-exome sequencing (WES) and T-cell receptor (TCR) sequencing on 40 tumor regions from four LP patients. The landscape and ITH at the genomic and immunological levels in LP tumors were compared with multiple cancers that have previously been reported. The lymphocyte infiltration was further assessed by immunohistochemistry (IHC) in LP tumors. In total, we identified 6339 non-silent mutations from multi-samples, with a median tumor mutation burden (TMB) of 3.30 mutations per Mb, comparable to gastric adenocarcinoma from the Cancer Genome Atlas …


Challenges And Opportunities In Achieving Sustainable Mud Crab Aquaculture In Tropical Coastal Regions, Elina Apine, Prashanth Ramappa, Ramachandra Bhatta, Lucy M. Turner, Lynda D. Rodwell Aug 2023

Challenges And Opportunities In Achieving Sustainable Mud Crab Aquaculture In Tropical Coastal Regions, Elina Apine, Prashanth Ramappa, Ramachandra Bhatta, Lucy M. Turner, Lynda D. Rodwell

School of Biological and Marine Sciences

Aquaculture plays a significant role in food security and provides livelihoods and employment for millions of people among coastal communities worldwide. However, the growing aquaculture sector has also created debates around its long-term ecological sustainability, economic viability, potential social inequalities and governance issues. We investigated the perceived challenges and opportunities to achieving sustainable mud crab aquaculture in tropical coastal regions by using the case study of coastal mud crab farms in Andhra Pradesh, India. Informed by perceptions and indicative financial data from a sample of stakeholders we investigated the potential economic outcomes under different scenarios representing varying yield levels, risk …


Development And Validation Of An Automated Image-Based Deep Learning Platform For Sarcopenia Assessment In Head And Neck Cancer, Zezhong Ye, Anurag Saraf, Yashwanth Ravipati, Frank Hoebers, Paul J Catalano, Yining Zha, Anna Zapaishchykova, Jirapat Likitlersuang, Christian Guthier, Roy B Tishler, Jonathan D Schoenfeld, Danielle N Margalit, Robert I Haddad, Raymond H Mak, Mohamed Naser, Kareem A Wahid, Jaakko Sahlsten, Joel Jaskari, Kimmo Kaski, Antti A Mäkitie, Clifton D Fuller, Hugo J W L Aerts, Benjamin H Kann Aug 2023

Development And Validation Of An Automated Image-Based Deep Learning Platform For Sarcopenia Assessment In Head And Neck Cancer, Zezhong Ye, Anurag Saraf, Yashwanth Ravipati, Frank Hoebers, Paul J Catalano, Yining Zha, Anna Zapaishchykova, Jirapat Likitlersuang, Christian Guthier, Roy B Tishler, Jonathan D Schoenfeld, Danielle N Margalit, Robert I Haddad, Raymond H Mak, Mohamed Naser, Kareem A Wahid, Jaakko Sahlsten, Joel Jaskari, Kimmo Kaski, Antti A Mäkitie, Clifton D Fuller, Hugo J W L Aerts, Benjamin H Kann

Faculty, Staff and Student Publications

Importance: Sarcopenia is an established prognostic factor in patients with head and neck squamous cell carcinoma (HNSCC); the quantification of sarcopenia assessed by imaging is typically achieved through the skeletal muscle index (SMI), which can be derived from cervical skeletal muscle segmentation and cross-sectional area. However, manual muscle segmentation is labor intensive, prone to interobserver variability, and impractical for large-scale clinical use.

Objective: To develop and externally validate a fully automated image-based deep learning platform for cervical vertebral muscle segmentation and SMI calculation and evaluate associations with survival and treatment toxicity outcomes.

Design, setting, and participants: For this prognostic study, …


Mirna Regulation Of Skeletal Muscle Hypertrophy, Maslyn Greene Aug 2023

Mirna Regulation Of Skeletal Muscle Hypertrophy, Maslyn Greene

All Dissertations

Muscle tissue is vital to animal survival and economically essential to livestock producers. Reduced muscle growth can occur from various reasons, including genetics, nutrition, and the pre and postnatal environment. Understanding the mechanisms behind muscle growth can aid in developing strategies to increase muscle mass. Several methods to increase muscle mass in livestock animals are currently being pursued, including nutrition, hormonal therapy, and genetic selection. One newly developing avenue is using miRNA technologies to change the expression of protein-coding genes. miRNA are a type of RNA that regulate over half of protein-coding gene expression. Here we evaluate muscle characteristics such …