Digital Commons Network^™

Revision Tracheotomy Complicated By History Of Follicular B-Cell Lymphoma, Sarah Ustrell, Jordan K Simmons, Garrett Henkle, Adam R Szymanowski

Faculty, Staff and Students Publications

This case report presents a 65-year-old woman with multiple complications during a revision tracheotomy including subcutaneous emphysema and a pneumothorax. Management of her airway was complicated by a history of recurrent follicular B-cell lymphoma associated with extensive cervical lymphadenopathy. We detail the importance of heightened clinical awareness and the use of intraoperative safety adjuncts when performing revision tracheostomies.

The Transcription Factor Chrebp Links Mitochondrial Lipidomes To Mitochondrial Morphology And Progression Of Diabetic Kidney Disease, Li Li, Jianyin Long, Koki Mise, Naravat Poungavrin, Philip L Lorenzi, Iqbal Mahmud, Lin Tan, Pradip K Saha, Yashpal S Kanwar, Benny H Chang, Farhad R Danesh

Faculty, Staff and Students Publications

A substantial body of evidence has established the contributions of both mitochondrial dynamics and lipid metabolism to the pathogenesis of diabetic kidney disease (DKD). However, the precise interplay between these two key metabolic regulators of DKD is not fully understood. Here, we uncover a link between mitochondrial dynamics and lipid metabolism by investigating the role of carbohydrate-response element-binding protein (ChREBP), a glucose-responsive transcription factor and a master regulator of lipogenesis, in kidney podocytes. We find that inducible podocyte-specific knockdown of ChREBP in diabetic db/db mice improves key biochemical and histological features of DKD in addition to significantly reducing mitochondrial fragmentation. …

The Role Of Bmi In Allostatic Load And Risk Of Cancer Death, Sydney E Andrzejak, Marquita W Lewis-Thames, Marvin E Langston, Yunan Han, Saira Khan, Darryl A Nettles, Lindsay N Fuzzell, Martha S Tingen, Justin X Moore

2020-Current year OA Pubs

INTRODUCTION: Obesity and proinflammatory conditions are associated with increased risks of cancer. The associations of baseline allostatic load with cancer mortality and whether this association is modified by body mass index (BMI) were examined.

METHODS: A retrospective analysis was performed in March-September 2022 using National Health and Nutrition Examination Survey years 1988 through 2010 linked with the National Death Index through December 31, 2019. Fine and Gray Cox proportional hazard models were stratified by BMI status to estimate subdistribution hazard ratios of cancer death between high and low allostatic load status (adjusted for age, sociodemographics, and health factors).

RESULTS: In …

Sharing And Caring: Creating A Culture Of Constructive Criticism In Computational Legal Studies, Corinna Coupette, Dirk Hartung

Research Collection Yong Pung How School Of Law

We introduce seven foundational principles for creating a culture of constructive criticism in computational legal studies. Beginning by challenging the current perception of papers as the primary scholarly output, we call for a more comprehensive interpretation of publications. We then suggest to make these publications computationally reproducible, releasing all of the data and all of the code all of the time, on time, and in the most functioning form feasible. Once all materials are made available by default, we invite constructive criticism in all phases of the publication life cycle. We posit that our proposals will help form our field, …

Alliance For Innovation On Maternal Health: Consensus Bundle On Sepsis In Obstetric Care., Melissa E Bauer, Catherine Albright, Malavika Prabhu, R Phillips Heine, Chelsea Lennox, Christie Allen, Carol Burke, April Chavez, Brenna L Hughes, Susan Kendig, Maile Le Boeuf, Elliott Main, Tiffany Messerall, Luis D Pacheco, Laura Riley, Rachel Solnick, Andrew Youmans, Ronald Gibbs

Women’s Health Articles

Sepsis in obstetric care is one of the leading causes of maternal death in the United States, with Black, Asian/Pacific Islander, and American Indian/Alaska Native obstetric patients experiencing sepsis at disproportionately higher rates. State maternal mortality review committees have determined that deaths are preventable much of the time and are caused by delays in recognition, treatment, and escalation of care. The "Sepsis in Obstetric Care" patient safety bundle provides guidance for health care teams to develop coordinated, multidisciplinary care for pregnant and postpartum people by preventing infection and recognizing and treating infection early to prevent progression to sepsis. This is …

The Emerging Importance Of Lymphatics In Health And Disease: An Nih Workshop Report, Babak J. Mehrara, Andrea J. Radtke, Gwendalyn J. Randolph, Brianna T. Wachter, Patricia Greenwel, Ilsa I. Rovira, Zorina S. Galis, Selen C. Muratoglu

2020-Current year OA Pubs

The lymphatic system (LS) is composed of lymphoid organs and a network of vessels that transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in the body. Abnormal development or malfunction of the LS has been shown to play a key role in the pathophysiology of many disease states. Thus, improved understanding of the anatomical and molecular characteristics of the LS may provide approaches for disease prevention or treatment. Recent advances harnessing single-cell technologies, clinical imaging, discovery of biomarkers, and computational tools have led to the development of strategies to study the LS. This Review summarizes the outcomes …

Nutritional Considerations For A New Era: A Cf Foundation Position Paper, Amanda Leonard, Marina Litvin, Et Al.

2020-Current year OA Pubs

OBJECTIVE: To provide interim advice and considerations to the CF Community around CF nutrition in the current era.

METHODS: The Cystic Fibrosis (CF) Foundation organized a multidisciplinary committee to develop a Nutrition Position Paper based on the rapidly changing nutrition landscape in CF, due in part to widespread use of cystic fibrosis transmembrane regulator highly effective modulator therapy (HEMT). Four workgroups were formed: Weight Management, Eating Behavior/Food Insecurity, Salt Homeostasis and Pancreatic Enzyme use. Each workgroup conducted their own focused review of the literature.

RESULTS: The committee summarized current understanding of issues pertaining to the four workgroup topics and provided …

The Pyruvate Dehydrogenase Complex Regulates Mitophagic Trafficking And Protein Phosphorylation, Panagiota Kolitsida, Vladimir Nolic, Jianwen Zhou, Michael Stumpe, Natalie M Niemi, Jörn Dengjel, Hagai Abeliovich

2020-Current year OA Pubs

The mitophagic degradation of mitochondrial matrix proteins in

Empowering Students As Leaders Of Behavior Change: An Experiential-Learning Project, Zachary Zenko, Alexis Fuston, Jafrā D. Thomas

Educational Practices in Kinesiology

The purpose of this resource is to allow university educators to implement an experiential-learning project in which students act as leaders of behavior change. Specifically, kinesiology students are paired with “clients” to engage with outside of the classroom and tasked with helping the clients achieve their physical activity goals. This semester-long behavior change project can be used in classes delivered in online, in-person, or hybrid formats. It is estimated that two hours are required for initial project instructions and set-up, with about 12 additional hours throughout the semester for continuous instruction, review, discussion, and presentation. Students are expected to benefit …

Science Of Hemp: Production And Pest Management Meeting Proceedings (2022)

Science of Hemp Annual Meeting

The third meeting of the Science of Hemp: Production and Pest Management held on November 3-4, 2022 at the University of Kentucky in Lexington, KY. Ninety-two agricultural scientists attended a series of scientific presentations. Topics included discipline-specific presentations in agronomy, entomology, horticulture, economics, and plant pathology, as well as general sessions. The abstracts for presentations and posters are included within this publication.

Using Near-Infrared Spectroscopy And Beets To Illuminate Nutrition Principles, Carrie E. Ellis

Educational Practices in Kinesiology

While near-infrared spectroscopy has been used in research and athletic development for some time, recent technological advances have made it accessible as an undergraduate learning tool. This teaching resource describes how near-infrared spectroscopy (NIRS) can be used in an in-person kinesiology laboratory. This activity illuminates nutrition principles, including issues with using supplements, deceptive marketing and labeling practices, and the value of nutrient-dense whole foods by observing vasodilation as a result of nitrate consumption in the form of whole beets and a beetroot supplement. In addition, using NIRS allows students to observe their body’s response to nitrates in real-time by measuring …

Disabilities And Medicine: From Stairs To Stares, Christopher Denham

HCA Healthcare Journal of Medicine

The current state of medicine has done little to correct the imbalance of underrepresented groups in the physician workforce. In this editorial, a psychiatric resident physician retells his experience as an individual who is completing his medical training while being affected by a neuromuscular disorder and how it impacts his daily life. The primary goal of this paper is to elucidate the need for greater representation and understanding of the disabled physician workforce.

Acute Esophageal Necrosis And Duodenal Disease In The Setting Of Recently Initiated Chemotherapy, Kulveer Dabb, Ryan Jansen Van Rensburg, Heba Yusuf, Daniel Klein, Alexander D. Lake, Mohamed Kaif

HCA Healthcare Journal of Medicine

Introduction

Acute esophageal necrosis (AEN), commonly referred to as “black esophagus” or Gurvits syndrome, is a rare condition characterized by diffuse black mucosa in the distal esophagus. Most often, the patient is an older male with multiple comorbidities, presenting with upper gastrointestinal bleeding. The exact pathogenesis is unclear, but it is often thought to be secondary to acute vascular hypo-perfusion or ischemia of the esophageal mucosa in critically ill patients with certain secondary comorbid conditions such as renal insufficiency, diabetes mellitus, dyslipidemia, coronary artery disease, malnourishment, alcohol abuse, or association with an underlying malignancy.

Case Presentation

We present a case …

Covid-19 Disease Characterization And Outcomes Comparison In Pediatrics, Rachel Rowland, Abigail Schauble, Brendon Cornett

HCA Healthcare Journal of Medicine

Background

It has been reported that children experience less severe COVID-19 symptoms than adults; however, the literature that supports this idea is evolving. The purpose of this study was to retrospectively characterize hospitalized COVID-19-positive pediatric patients with a focus on the assessment of risk factors for poorer outcomes, mortality, and evaluation of interventions utilized and associated clinical outcomes.

Methods

We conducted a multi-center retrospective chart review of patients 18 years old or younger who were COVID-19 positive and admitted to any US HCA Healthcare Pediatric service line between January 1, 2020, and November 30, 2020. We identified 6081 children across …

Attenuation Of Diabetes-Mediated Muscle Atrophy In Rats By Fish Oil Enriched Omega-3 Polyunsaturated Fatty Acids Supplementation, Shing-Hwa Liu, Wei-Hsuan Lin, Huei-Ping Tzeng, Meng-Tsan Chiang

Journal of Food and Drug Analysis

Diabetes is associated with an increased risk of muscle wasting/atrophy, which adversely affects quality of life. We hypothesized that long term supplementation of fish oil may have protective effects against sarcopenia or muscle atrophy in streptozotocin (STZ) and high-fat (HF) diet-induced diabetic rat model. Wistar rats at age of 7 weeks were injected with saline or STZ to induce hyperglycemia. After one week, they were fed on a normal control diet or HF diet with/without supplementation of fish oil for 18 weeks. Feeding diabetic rats with a fish oil-enriched diet alleviated body weight loss and the impaired glucose tolerance using …

Determination And Evaluation Of Epa And Dha Ethyl Esters In Fish Oils Using The Tmah Transesterification Method, Pai-Wen Wu, Ching-Hsuan Tsai, Ching-Yu Hsu, Shu-Han Chang, Ya-Min Kao, Su-Hsiang Tseng, Der-Yuan Wang

Journal of Food and Drug Analysis

A simple and dependable technique, known as THAM method, has been developed to detect and measure ethyl eicosapentaenoate (EE-EPA) and ethyl docosahexaenoate (EE-DHA) in encapsulated fish oils. This technique involves using tetramethylammonium hydroxide (TMAH) as a catalyst, followed by analysis using gas chromatography equipped with a flame ionization detector. Recoveries of EE-EPA and EE-DHA spiked between 5 mg/g and 20 mg/g were found to be between 90.8% and 95.2%, with coefficients of variation ranging from 0.2% to 2.5%, demonstrating the accuracy and precision of the technique. Additionally, its limitation of quantitation of EE-EPA and EE-DHA in fish oil samples was …

Cannabis Sativa L.: A Comprehensive Review On Legislation, Decriminalization, Phytochemistry, Antimicrobial Activity, And Safety, Mohammed Dalli, Salah-Eddine Azizi, Ali Azghar, Abderrazak Saddari, Elmostapha Benaissa, Yassine Ben Lahlou, Mostafa Elouennass, Adil Maleb

Journal of Food and Drug Analysis

Throughout history, medicinal and aromatic plants have been used extensively to cure a variety of ailments. This article provides a comprehensive overview of Cannabis sativa, specifically focusing on its legislative status, decriminalization, phytochemistry, antimicrobial activity, and safety. The study begins by briefly outlining the plant's history, including its cultivation, harvesting, and storage methods. The review analyzes extensively the antimicrobial properties of Cannabis sativaand its derivatives, specifically examining their reported antiviral, antibacterial, antifungal, and antiparasitic capabilities, which have been documented in databases such as Scopus, ScienceDirect, PubMed, and Web of Science. The paper also discusses trends in studies about the …

Effects Of Green Tea–Derived Natural Products On Resistance Exercise Training In Sarcopenia: A Retrospective Narrative Mini-Review, Hung-Wen Liu, Sue-Joan Chang

Journal of Food and Drug Analysis

Skeletal muscle function deficits result in metabolic disease development and physical dysfunction in older adults. Sarcopenia is characterized by a decrease in muscle mass and strength with advancing age, and it increases the risks of mobility impairments, disease development, and mortality. Lifestyle interventions involving a combination of diet and exercise to prevent and attenuate sarcopenia warrant substantial research attention. Resistance exercise training under supervision is a safe and the most effective approach to reducing age-related muscle loss and improving multiple aspects of overall health in the older population. The beneficial effects of resistance exercise training on skeletal muscle mass may …

White-Tailed Deer (Odocoileus Virginianus) Fawn Survival And The Influence Of Landscape Characteristics On Fawn Predation Risk In The Southern Appalachian Mountains, Usa, Adam C. Edge, Jacalyn P. Rosenberger, Cheyenne J. Yates, Andrew R. Little, Charlie H. Killmaster, Kristina L. Johannsen, David A. Osborn, John C. Kilgo, Karl V. Miller, Gino J. D’Angelo

School of Natural Resources: Faculty Publications

In the Southern Appalachian region of the United States, harvest data has indicated the occurrence of low deer densities while exposing a trend of declining white-tailed deer (Odocoileus virginianus) populations over the past several decades in northern Georgia. A triumvirate of increasing fawn predator populations reside in the Southern Appalachian Mountains including coyotes (Canis latrans), black bears (Ursus americanus) and bobcats (Lynx rufus). This region is also characterized by a homogenous landscape composed of mature forests and sparse understory vegetation, likely lacking adequate cover to offer fawns refugia from predators. Our objectives …

Computational And Experimental Investigation Of Elemental Sulfur And Polysulfide, Jyoti Sharma

Dissertations

Petroleum processing results in the generation of significant quantities of elemental sulfur (S₈), leading to a surplus of sulfur worldwide. Despite its abundance and low cost, the use of sulfur in value-added organic compound synthesis is limited due to its unpredictable and misunderstood reactivity. This dissertation aims to address this issue by tackling it from two angles. Firstly, by utilizing Density Functional Theory (DFT) calculations, the reactivity of sulfur in the presence of nucleophiles is studied. This facilitates the identification of organic polysulfide intermediates that can be generated under different conditions, as well as the corresponding reactivity for …

Bertumbuh Berkembang: Modul Pemberian Makan Bayi Dan Anak (Pmba), Hikmah Kurniasari

Pengembangan Profesional

Pemberian Makanan Bayi dan Anak (PMBA) yang optimal akan meningkatkan kesempatan hidup dan pertumbuhan anak; juga daya tangkap untuk menguasai keterampilan serta pengetahuan yang mereka perlukan sebelum memulai pendidikan di tahun-tahun awal sekolah. Tidak hanya bagi bayi dan anak, pemenuhan gizi yang baik juga amat penting bagi ibu hamil dan menyusui. Selain penjelasan lengkap seputar PMBA dan kesehatan ibu hamil/menyusui, modul ini juga menjelaskan kepercayaan lokal yang kepercayaan lokal yang terkadang menimbulkan misinformasi dan menghambat akses bagi ibu, bayi, dan anak untuk mendapatkan nutrisi yang dibutuhkan. Modul ini akan bermanfaat bagi kader layanan kesehatan (Posyandu) untuk menyampaikan informasi yang tepat …

Workload And Stress Level In Non-Covid-19 Zoning Nurses At National Central Public Hospital Jakarta, Zakiyah Zakiyah, Ulfah Nuraini Karim, Aliana Dewi, Siti Nuraini, Aan Sutandi, Rony Darmawansyah Alnur

Kesmas

The COVID-19 pandemic has increased the workload for nurses directly handling COVID-19 patients and those working in non-COVID-19 zones. As the number of COVID-19 cases rises, nurses face psychological problems, including stress. This study aimed to determine the relationship between workload and stress levels in a non-COVID-19 zoning ward using a cross-sectional approach and Spearman’s correlation test conducted on 94 nurses at one hospital in Jakarta, Indonesia, selected through simple random sampling. The workload questionnaire with 15 items and the DASS 42 questionnaire were used to measure stress levels. The results indicated that most nurses (73.4%) experienced a heavy workload. …

Knowledge, Awareness, And Perceived Barriers Regarding Cervical Cancer Screening Among Bangladeshi Women Suffering From Cervical Cancer: A Cross-Sectional Study, Muhammed Mohibul Islam, Farhana Sultana, Md Hasan Shahriar Rahman, Nandita Islam Pia, Md. Al Hasibuzzaman, Arman Ahmed, Mohammed Shamim Hasan, Md Kayes Mahmud, Rabeya Akter, Md. Saqline Mostaq, Mohammad Nurul Amin

Makara Journal of Health Research

Background: This study aimed to evaluate the knowledge, awareness, and perceived barriers regarding cervical cancer screening among women in Bangladesh.

Methods: A hospital-based survey was conducted from January to April 2021 among 200 female participants. Statistical analysis of this study was performed by using Stata 13 (StataCorp LP, 4905 Lakeway Drive, College Station, TX 77845, USA), where Chi-square test was used for the determination of the correlation among different variables.

Results: Among the participants, 86.5% were rural residents, 96% were married, 87.5% were housewives, 47% were uneducated, and 93.5% lived on a husband’s income. Moreover, 84.5% hadn’t …

Designing A Mhealth App-Based Intervention To Address The Harm Reduction Needs Of Malaysian Men Who Have Sex With Men (Msm) Who Engage In Chemsex: Findings From A Qualitative Study, Christopher Uyar, Francesca Maviglia, Jeffery Wickersham, Antoine Khati, Olivia Kennedy, Nicholas Copenhaver, Mohd Akbar Ab Halim, Wan Mohd Ikhtiaruddin, Isklander Azwa, Kamal Gautam, Roman Shrestha

Honors Scholar Theses

Background:

Chemsex (the use of drugs by men who have sex with men (MSM) to enhance the sexual experience) is being identified as an increasingly common phenomenon. In Malaysia, where drug use and homosexuality are criminalized, chemsex fosters multiple and simultaneous risk-taking behaviors that endanger MSM's well-being and safety. Exacerbating these risks is the intolerant Malaysian sociopolitical environment that foregoes support and victimizes MSM. Malaysian MSM is thus a hidden and at-risk population.

Objective:

We probed Malaysian MSM's thoughts and opinions to guide the development of a potential chemsex mHealth intervention. This hypothetical app-based intervention could serve as a harm-reduction …

Obtaining Sweet Molasses By The Method Of Hydromechanical And Enzymatic Processing Of Grain, Sadritdin Maxamatdinovich Turabdjanov, Kamoliddin Ahmadjonovich Mahmudov, Bexzod Alisherovich Kasimov, Kasun Dissanayake Kumara

Chemical Technology, Control and Management

Methods of hydrolysis of grains to starch under the influence of hydrodynamic and enzymatic processes are logically based. Polysaccharides derived from starchy grains are known and popular in the food industry for their thickening and stabilizing properties. To date, studies that allow for a deeper understanding of the mechanism of interaction of polysaccharide-containing products with their main components, the effect on the set of rheological, organoleptic, physico-chemical properties of food products that determine their functions are relevant.

Illness-Related Attitudes Toward Covid-19 And Precautionary Practices Among Kuwaiti Males During The Total Lockdown And Curfew In Kuwait Illness-Related Attitudes Toward Covid-19 And Precautionary Practices Among Kuwaiti Males During The Total Lockdown And Curfew In Kuwait, Hend Batel Al-Ma’Seb, Maha Meshari Al-Sejari

Journal of Arts and Social Sciences

COVID-19 is a worldwide pandemic that affects individuals’ physical and mental health. The aim of this descriptive cross sectional study was to investigate relationships between precautionary practices (washing hands, taking vitamins, and eating a healthy diet) and attitudes about illness related to COVID-19 (worry about illness, concern about pain, hypochondriacal beliefs, thanatophobia, and treatment experience). This study used non-probability sample method to recruit the participants. The study sample was restricted to males who were 18 and older and who lived in Kuwait during the COVID-19 pandemic. A total of 430 males volunteered to participate in this study. The participants completed …

Comparative Polar And Lipid Plasma Metabolomics Differentiate Kshv Infection And Disease States, Sara R. Privatt, Camila Pereira Braga, Alicia Johnson, Salum J. Lidenge, Luke Berry, John R. Ngowi, Owen Ngalamika, Andrew G. Chapple, Julius Mwaiselage, Charles Wood, John T. West, Jiri Adamec

School of Medicine Faculty Publications

Background: Kaposi sarcoma (KS) is a neoplastic disease etiologically associated with infection by the Kaposi sarcoma-associated herpesvirus (KSHV). KS manifests primarily as cutaneous lesions in individuals due to either age (classical KS), HIV infection (epidemic KS), or tissue rejection preventatives in transplantation (iatrogenic KS) but can also occur in individuals, predominantly in sub-Saharan Africa (SSA), lacking any obvious immune suppression (endemic KS). The high endemicity of KSHV and human immunodeficiency virus-1 (HIV) co-infection in Africa results in KS being one of the top 5 cancers there. As with most viral cancers, infection with KSHV alone is insufficient to induce tumorigenesis. …

Topiramate (Topamax): Evolving Role In Weight Reduction Management: A Narrative Review, Irza Wajid, Alexis Vega, Katherine Thornhill, Jack Jenkins, Chandler Merriman, Debbie Chandler, Sahar Shekoohi, Elyse M. Cornett, Alan D. Kaye

School of Medicine Faculty Publications

Obesity has emerged as a widespread disease with epidemic proportions, necessitating effective management to enhance the overall health outcomes of patients. Medical intervention for weight loss becomes necessary when diet and exercise prove ineffective, and topiramate emerges as a potential treatment option for this global problem. Currently approved as an anti-epileptic and migraine prophylaxis medication, topiramate is frequently utilized as adjunctive therapy for patients with mood and eating disorders, as well as for alcohol use disorders. Its multifaceted mechanisms of action contribute to reducing neuronal excitation and enhancing neuronal inhibition. Given its variety of mechanisms, topiramate shows several off-label outcomes, …

A Qualitative Exploration Of Exclusive Breastfeeding Practices Among Karen Ethnicity Mothers In Northern Thailand Remote Rural Areas, Wanchalerm Ritthimon, Aksara Thongprachum, Jukkrit Wungrath

Kesmas

Low exclusive breastfeeding rates among the Karen ethnic group in Northern Thailand's remote rural areas underscore the need to understand knowledge, attitudes, and social support to develop targeted interventions. This qualitative study examined exclusive breastfeeding practices and the factors influencing breastfeeding behavior among 14 Karen Ethnicity Mothers (KEMs) in Northern Thailand. A structured interview was used to collect the data, a triangular method to determine the data's validity, and a content analysis method to examine the data revealed seven themes and 14 subthemes. This study identified three key factors for successful breastfeeding: self-motivation, social support, and effective problem management, which …

Healthy Lifestyle Behaviors And Sociodemographic Characteristics Among Medical Students In Indonesia During The New Normal Era: A Cross-Sectional Study, Sharren Shera Vionnetta, Tommy Nugroho Tanumihardja, Kevin Kristian

Kesmas

This study aimed to identify medical students’ healthy lifestyle behaviors during the new normal era and to determine its relationship with sociodemographic factors, bearing in mind that, as future physicians and health role models, medical students play an important role in adopting and promoting healthy lifestyle behaviors to reduce the risk of future health problems as well as optimize communities’ health status. This cross-sectional study was conducted at the School of Medicine and Health Sciences of Universitas Katolik Indonesia Atma Jaya, with 111 medical students selected through stratified random sampling. Data were collected using sociodemographic characteristics (sex, residence, year of …