Digital Commons Network^™

Arabidopsis Thaliana Growth More Than Defense Affects Myzus Persicae Populations, Biran S. Falk-Dotan, Mindy Chapman, Nafis Wazed, Chad T. Harvey

International Journal of Undergraduate Research and Creative Activities

Aphids and other herbivorous insects are able to travel between plants in their environment. While plants cannot directly choose their consumers, they may stop or mitigate the harmful effects of herbivory using secondary metabolites. A salicylic acid (SA) pathway facilitates defense from biotrophic fungi and some necrotrophic pathogens, while a jasmonic acid (JA) pathway is associated with defense from other necrotrophic pathogens and chewing insects. We investigated the effect of deficiency in SA or JA in Arabidopsis thaliana on plant growth and on herbivory by green peach aphids (Myzus persicae). Three ascensions of A. thaliana were placed in two blocks …

The Geography Of Food Cooperatives In The United States, Seth T. Young

International Journal of Undergraduate Research and Creative Activities

For our society to become sustainably viable in the future, the ways in which we obtain our food and the methods used to create that food will be very important. One of the most environmentally friendly methods of food obtainment is membership in a food cooperative. This research delves into the basics of food cooperatives, highlights similar studies of other sustainability indicators, and examines the geographic distribution of food co-ops across the United States.Faculty Sponsor: Dr. George Pomeroy

Pluralism And Foundationalism In The Applied Sciences, David Baker

International Journal of Undergraduate Research and Creative Activities

Nancy Cartwright develops her scientific pluralism within The Dappled World and argues for its supremacy over foundationalism. Cartwright believes that the sciences should be applied for humane benefits and not for knowledge’s sake alone. However, Cartwright does not give enough credit to the practical applications produced by foundationalists. Cartwright’s goals are not hindered or detracted from when working with foundationalists. In fact foundationalism and pluralism offer complimentary means of practical application, the outcome of which is a bettered ability to apply our sciences towards practical concerns than either position offers alone. I will use exemplary cases demonstrating these isolated shortcomings …

A Proof-Of-Concept Pilot Test Of A Behavioral Intervention To Improve Adherence To Dietary Recommendations For Cancer Prevention, Meghan Butryn, Charlotte Hagerman, Nicole Crane, Marny Ehmann, Evan Forman, Brandy-Joe Milliron, Nicole L. Simone

Department of Radiation Oncology Faculty Papers

OBJECTIVES: Prevention programs that can help adults improve the quality of their diets to reduce cancer risk are needed. This Phase IIa study prospectively tested a mHealth intervention designed to improve adherence to dietary quality guidelines for cancer prevention.

METHODS: All participants (N = 62) received nutrition education and a self-regulation skills curriculum, with a primary target of changing grocery shopping behavior. Using a randomized, factorial design, the study varied whether each of the following 4 components were added to the 20-week intervention: (1) location-triggered app messaging, delivered when individuals arrived at grocery stores, (2) reflections on benefits of change, …

Nrg/Rtog 0837: Randomized, Phase Ii, Double-Blind, Placebo-Controlled Trial Of Chemoradiation With Or Without Cediranib In Newly Diagnosed Glioblastoma, Tracy T. Batchelor, Minhee Won, Arnab Chakravarti, Costas G. Hadjipanayis, Wenyin Shi, Lynn S. Ashby, Volker W. Stieber, H. Ian Robins, Heidi J. Gray, Alfredo Voloschin, John B. Fiveash, Clifford G. Robinson, Ushasree Chamarthy, Young Kwok, Terrence P. Cescon, Anand K. Sharma, Rekha Chaudhary, Mei-Yin Polley, Minesh P. Mehta

Department of Radiation Oncology Faculty Papers

BACKGROUND: A randomized, phase II, placebo-controlled, and blinded clinical trial (NCT01062425) was conducted to determine the efficacy of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, versus placebo in combination with radiation and temozolomide in newly diagnosed glioblastoma.

METHODS: Patients with newly diagnosed glioblastoma were randomly assigned 2:1 to receive (1) cediranib (20 mg) in combination with radiation and temozolomide; (2) placebo in combination with radiation and temozolomide. The primary endpoint was 6-month progression-free survival (PFS) based on blinded, independent radiographic assessment of postcontrast T1-weighted and noncontrast T2-weighted MRI brain scans and was tested using a 1-sided …

Learning To Adapt: The Vital Role Of Education And Gender Equity In Climate Justice, Nicole Haberland, Jessie Pinchoff

Gender Equality and Equity

No abstract provided.

Updates In Sjs/Ten: Collaboration, Innovation, And Community., Madeline E. Marks, Ramya Krishna Botta, Riichiro Abe, Thomas M. Beachkofsky, Isabelle Boothman, Bruce C. Carleton, Wen-Hung Chung, Ricardo R. Cibotti, Roni P Dodiuk-Gad, Christian Grimstein, Akito Hasegawa, Jay H. Hoofnagle, Shuen-Iu Hung, Benjamin Kaffenberger, Daniela Kroshinsky, Rannakoe J. Lehloenya, Michelle Martin-Pozo, Robert G. Micheletti, Maja Mockenhaupt, Keisuke Nagao, Suman Pakala, Amy Palubinsky, Helena B. Pasieka, Jonathan Peter, Munir Pirmohamed, Melissa Reyes, Hajirah N. Saeed, Jeffery Shupp, Chonlaphat Sukasem, Jhih Yu Syu, Mayumi Ueta, Li Zhou, Wan-Chun Chang, Patrice Becker, Teresa Bellon, Kemberlee Bonnet, Gianpiero Cavalleri, James Chodosh, Anna K. Dewan, Arturo Dominguez, Xinzhong Dong, Elena Ezhkova, Esther Fuchs, Jennifer Goldman, Sonia Himed, Simon Mallal, Alina Markova, Kerry Mccawley, Allison E. Norton, David Ostrov, Michael Phan, Arthur Sanford, David Schlundt, Daniel Schneider, Neil Shear, Kanade Shinkai, Eric Tkaczyk, Jason A. Trubiano, Simona Volpi, Charles S. Bouchard, Sherrie J. Divito, Elizabeth J. Phillips

Manuscripts, Articles, Book Chapters and Other Papers

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a predominantly drug-induced disease, with a mortality rate of 15-20%, that engages the expertise of multiple disciplines: dermatology, allergy, immunology, clinical pharmacology, burn surgery, ophthalmology, urogynecology, and psychiatry. SJS/TEN has an incidence of 1-5/million persons per year in the United States, with even higher rates globally. One of the challenges of SJS/TEN has been developing the research infrastructure and coordination to answer questions capable of transforming clinical care and leading to improved patient outcomes. SJS/TEN 2021, the third research meeting of its kind, was held as a virtual meeting on August 28-29, 2021. The …

Nrg/Rtog 0837: Randomized, Phase Ii, Double-Blind, Placebo-Controlled Trial Of Chemoradiation With Or Without Cediranib In Newly Diagnosed Glioblastoma, Minesh Mehta

All Publications

Background: A randomized, phase II, placebo-controlled, and blinded clinical trial (NCT01062425) was conducted to determine the efficacy of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, versus placebo in combination with radiation and temozolomide in newly diagnosed glioblastoma.

Methods: Patients with newly diagnosed glioblastoma were randomly assigned 2:1 to receive (1) cediranib (20 mg) in combination with radiation and temozolomide; (2) placebo in combination with radiation and temozolomide. The primary endpoint was 6-month progression-free survival (PFS) based on blinded, independent radiographic assessment of postcontrast T1-weighted and noncontrast T2-weighted MRI brain scans and was tested using …

A Critical Exploration Of The Diets Of Uk Disadvantaged Communities To Inform Food Systems Transformation: A Scoping Review Of Qualitative Literature Using A Social Practice Theory Lens, Louise Hunt, Clare Pettinger, Carol Wagstaff

School of Health Professions

The UK food system affects social, economic and natural environments and features escalating risk of food insecurity. Yet it should provide access to safe, nutritious, affordable food for all citizens. Disadvantaged UK communities [individuals and families at risk of food and housing insecurity, often culturally diverse] have often been conceptualised in terms of individual behaviour which may lead to findings and conclusions based on the need for individual change. Such communities face public health challenges and are often treated as powerless recipients of dietary and health initiatives or as ‘choiceless’ consumers within food supply chains. As transforming the UK food …

The Effects Of Immediate Static Stretching On Exercise Induced Inflammation And Doms Following An Acute Bout Of Eccentric Exercise Of The Triceps, Valarie R. Dimartino

Seton Hall University Dissertations and Theses (ETDs)

Introduction: Delayed onset muscle soreness (DOMS) is caused by the body's immune system attempting to heal damaged muscles, creating exercise induced inflammation. DOMS impacts exercise performance and adherence. Treatments provide temporary relief yet fail to inhibit the mechanism of inflammation. Purpose: The purpose of this quantitative investigation was to explore the effect of immediate static stretching on the inflammatory response and subsequent DOMS following an acute bout of eccentric triceps dips. Inflammation was measured via triceps girth (cm) and self-reported Visual Analog Scale (VAS) ratings of DOMS. Methods: 24 healthy adult participants (27.4 ± 7.5 yrs., 80 ± …

Dbapis: A Database Of Anti-Prokaryotic Immune System Genes, Yuchen Yan, Jinfang Zheng, Xinpeng Zhang, Yanbin Yin

Food for Health: Publications

Anti-prokary otic immune sy stem (APIS) proteins, typically encoded b y phages, prophages, and plasmids, inhibit prokaryotic immune systems (e.g. restriction modification, to xin-antito xin, CRISPR-Cas). A gro wing number of APIS genes ha v e been characterized and dispersed in the literature. Here w e de v eloped dbAPIS ( https:// bcb.unl.edu/ dbAPIS ), as the first literature curated data repository for experimentally verified APIS genes and their associated protein f amilies. T he k e y features of dbAPIS include: (i) e xperimentally v erified APIS genes with their protein sequences, functional annotation, PDB or AlphaFold predicted str …

Northeast Tennessee Educators’ Perceptions Of Academic Outcomes Of High School Students Who Completed A Community-Based, Resilience-Informed Course Presented At School, Carla Whiles

Ed.D. Dissertations

Adverse childhood experiences negatively affected the mental and physical health of adults and children and were linked to cognitive difficulties and decreased academic outcomes at all levels of education. Resilience, the ability for one to bounce back from adversity, was widely accepted to mitigate the negative effects of adversities and resilience intervention programs were becoming more common in schools. The purpose of this qualitative interpretive study was to examine northeast Tennessee educators’ perceptions of the academic outcomes of high school students who completed a community-based, resilience-informed course presented at school. After conducting semi-structured interviews with 11 participants, I discovered the …

Nurturing Community: Using Community-Based Service Learning In Biopharmaceutical Engineering Education., Miriam I Jiménez-Pérez, Yocanxóchitl Perfecto-Avalos., Mariana C Orellana- Haro

Research Papers

This project evaluates the use of CBSL as a strategy for teaching clinical investigation in the development of biopharmaceutical products based on the nutritional needs of children of a low-income community. To achieve this purpose, our students formulated various functional foods that provided the necessary nutrients for the children in the target community. Afterwards, they drafted the corresponding clinical protocols for each formulation, considering possible ethical implications. The academic evaluation was based on the comparison of courses with and without CBSL. The study found that students showed a slight improvement in academic performance with CBSL. This suggests that CBSL can …

Embedding Competencies In Sustainability And Authentic Learning Experiences In Food Science Education Through A Study Program-Driven Approach, Anita Nordeng Jakobsen, Sunniva Hoel, Ida-Johanne Jensen

Research Papers

The food sector is experiencing a substantial shift towards Industry 4.0 regarding technological solutions to ensure efficient and sustainable food production. To face the required changes and be able to influence and change existing systems, future candidates must have solid capabilities in their respective subject areas as well as generic skills such as critical thinking, reflection, communication, and teamwork skills. At NTNU, a program-driven approach for embedding sustainability and authentic learning experiences in the bachelor program of Food Science, technology and sustainability was conducted. Thematic groups of staff members developed learning outcomes and learning- and assessment methods to ensure coherence …

Trauma-Informed Educational Leadership: A Case Study, Robyn Scott

Doctor of Education in Educational Leadership Dissertations

This research study offers an exploratory examination into the lived experiences of educational leaders managing the implementation and facilitation of Trauma-Skilled Schools (TSS) in the post-COVID-19 pandemic context. This study details the unique challenges and opportunities experienced while planning and executing TSS, aiming to equip school staff to better address trauma-affected behaviors. Utilizing case study methods, including in-depth interviews and document analysis, this research uncovers practices, strategies, and challenges, offering an insider's perspective on leading TSS initiatives. Findings indicate a necessity for comprehensive, job-embedded professional learning, continuous support from educational leadership, and organizational change in school policy, practice, and mindset, …

Economic Equity And People With Disabilities: Development And Characterization Of A Novel Index, Bhavneet Walia, Katherine Mcdonald, Barry Whaley, Vinh Nguyen

Burton Blatt Institute

Here, we develop two new social indices: the ADA PARC Absolute Economic Opportunity Index and the ADA PARC Relative Economic Opportunity Index. These indices allow us novel examinations of economic equity between people with and without disabilities within a U.S. state and between people with disabilities in different states using aggregations of multiple component economic indicators. These represent the first efforts to offer U.S. indices of this focus, an important development given the distinct economic needs of people with disabilities and the value in accounting for distinct national policies. The indices rely on U.S. Census and other data on economic …

The Design And Impact Of A Clinic-Based Community Program On Food Insecurity, Healthy Eating Behaviors, And Mood, Tiffany Wesley Ardoin, Elizabeth Perry, Chelsea Morgan, Jared Hymowitz, Donald Mercante

School of Medicine Faculty Publications

Food insecurity is a national issue that disproportionately impacts Louisiana citizens, contributing to the state’s poor health outcomes. We know that the Supplemental Nutrition Assistance Program (SNAP) and food pantries improve access to food, but we have limited data on what interventions improve food insecurity. The Geaux Get Healthy Clinical Program at Our Lady of the Lake (GGHOLOL) is a clinic-based community program that leverages community partnerships and a clinical setting to provide education and access to resources for individuals with food insecurity. This prospective study examines the impact of GGHOLOL on food insecurity as a pre-post survey evaluation over …

Sex Differences In Cholesterol And Triglyceride Levels Among Hospitalized Adolescents And Young Adults With Eating Disorders, Jason M. Nagata, Anita V. Chaphekar, Ruben Vargas, Anthony Nguyen, Amanda E. Downey, Khushi P. Patel, Kyle T. Ganson, Elena Stuart, Siena Vendlinski, Sara M. Buckelew, Andrea K. Garber

Publications

OBJECTIVE: To determine sex differences in cholesterol and triglyceride levels among adolescents and young adults hospitalized for medical complications of eating disorders. METHODS: A retrospective electronic medical record review of patients aged 9-25 years admitted to the University of California, San Francisco Eating Disorders Program for medical stabilization, between 2012 and 2020, was conducted. Non-fasting total cholesterol and triglycerides were collected; however, LDL and HDL levels were not available. RESULTS: Among 83 males and 441 females, mean ± SD age was 15.5 ± 2.8 years, 64.1% had anorexia nervosa, and admission percent median body mass index was 87.3 ± 13.9. …

Novel Treatments For Pxe: Targeting The Systemic And Local Drivers Of Ectopic Calcification, Ida Joely Jacobs, Qiaoli Li

Department of Biochemistry and Molecular Biology Faculty Papers

Pseudoxanthoma elasticum (PXE) is a heritable multisystem ectopic calcification disorder. The gene responsible for PXE, ABCC6, encodes ABCC6, a hepatic efflux transporter regulating extracellular inorganic pyrophosphate (PPi), a potent endogenous calcification inhibitor. Recent studies demonstrated that in addition to the deficiency of plasma PPi, the activated DDR/PARP signaling in calcified tissues provides an additional possible mechanism of ectopic calcification in PXE. This study examined the effects of etidronate (ETD), a stable PPi analog, and its combination with minocycline (Mino), a potent inhibitor of DDR/PARP, on ectopic calcification in an Abcc6-/- mouse model of PXE. Abcc6-/- mice, at 4 weeks of …

Paired Liver:Plasma Pfas Concentration Ratios From Adolescents In The Teen-Labs Study And Derivation Of Empirical And Mass Balance Models To Predict And Explain Liver Pfas Accumulationn, Brittney O Baumert, Fabian C Fischer, Flemming Nielsen, Philippe Grandjean, Scott Bartell, Nikos Stratakis, Douglas I Walker, Damaskini Valvi, Rohit Kohli, Thomas Inge, Justin Ryder, Todd Jenkins, Stephanie Sisley, Stavra Xanthakos, Sarah Rock, Michele A La Merrill, David Conti, Rob Mcconnell, Lida Chatzi

Faculty, Staff and Students Publications

Animal studies have pointed at the liver as a hotspot for per- and polyfluoroalkyl substances (PFAS) accumulation and toxicity, however, these findings have not been replicated in human populations. We measured concentrations of seven PFAS in matched liver and plasma samples collected at the time of bariatric surgery from 64 adolescents in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. Liver:plasma concentrations ratios were perfectly explained (r2 > 0.99) in a multi-linear regression (MLR) model based on toxicokinetic (TK) descriptors consisting of binding to tissue constituents and membrane permeabilities. Of the seven matched plasma and liver PFAS concentrations compared in this …

Evangelical School Of Nursing Bulletin, 1976-1978, Advocate Aurora Health

Historical Documents - Combined

Evangelical School of Nursing, Oak Lawn, IL: Brochure advertising the Evangelical School of Nursing. Includes information on school policies, education requirements, and a course catalog.

Evangelical School Of Nursing Bulletin, 1982-1985, Advocate Aurora Health

Historical Documents - Combined

Evangelical School of Nursing, Oak Lawn, IL: Brochure advertising the Evangelical School of Nursing. Includes information on school policies, education requirements, and a course catalog.

Evangelical School Of Nursing Student Handbook, 1982-1985, Advocate Aurora Health

Historical Documents - Combined

Evangelical School of Nursing, Oak Lawn, IL: Student handbook for the Evangelical School of Nursing. Includes information on school policies, residency halls, education requirements, and a course catalog.

Developing A Child-Friendly Outdoor Public Playground For Children Aged 4-8, Through Co-Creation Mindset, Neda Batenipour

IASDR Conference Series

Outdoor playgrounds, as part of urban space, with their equipment/settings play an important role in child development. For designing a child-friendly playground, looking at a playground through the eyes of children as end users should be of prime importance for designers. This study presents a new framework and methodology for exploring design parameters based on users’ real needs and wants and finally designs a child-friendly outdoor public playground for children aged 4-8 years old. Existing problems, gaps, and opportunities in Wuppertal’s playgrounds – especially in the Nordbahntrasse and Parkour Park area – provide the rationale and need, as well as …

Increasing Preventive Care Through Increased Access To Healthy Foods, Danijela Kaurin, Sarah Syed, Bahra Chabo, Gulad Ali, Adam Sagerman, Santosh Basapur

IASDR Conference Series

Food deserts are areas that lack the availability of fresh, affordable, and nutritious foods. Almost half of the food in the United States of America is wasted every year, yet somehow there are thousands of food deserts. This lack of nutritious food for people of all ages negatively impacts health outcomes as chronic diseases like obesity, diabetes, and heart disease are rising quickly. Preventive care is a practice in which patients take the initiative to make healthier choices in life to prevent the onset or progression of chronic illness. An example of such initiatives is eating and preparing more nutritious …

Co-Design For Interdisciplinary Research Communities, P.J. White, Colin Deevy, Brian Casey, Audrey Patocs, Parminder Raina

IASDR Conference Series

Complex research challenges facing society today require an integrative approach, therefore, interdisciplinary research is now required more often. By creating interdisciplinary research communities, we facilitate communication, collaboration, and knowledge sharing between researchers from different fields. It can however be difficult to create interdisciplinary communities within universities, but co-design methods have been seen as being beneficial in doing so. Reporting and reflecting on three case studies (including N=130 participants), this paper aims to explore the use of co-design methods in creating interdisciplinary research communities In this paper, we focus on two main characteristics of co-design workshops. 1. Design/ Scheduling and Planning …

Design Futures To Support Sustainable Food Practices, Marita Canina, Eva Monestier

IASDR Conference Series

The Digital Transformation of the European economy is crucial to preserve and boost international competitive advantages. Companies and public organizations need to integrate digital technologies into their processes, products, and services to benefit from the efficiency gains while remaining environmentally sustainable. A green transformation is indeed a crucial step to protect the health and wellbeing of citizens from environment-related risks. In this sense, digital technologies are enablers to reach the European Sustainable Development Goals (SDGs). Fostering experimentation with cutting-edge technologies to innovate the future of food and improve human and planet wellbeing is a challenge that provides companies with opportunities …

Design-Driven Poverty Alleviation: An Approach That Turns Poverty Alleviation From A Cost Perspective To A Resource Perspective, Yuhui Jin, Peng Xu

IASDR Conference Series

[Background & Challenges] Traditional poverty alleviation is a high-cost matter. In many cases, poverty alleviation is regarded as a ‘cost’ that a society needs to pay. However, the existing practices of Design for Poverty Alleviation still focused more on the application of product design and appearance improvement and had not fully tapped the potential of Design. [Objective] This study aims to use Design at a higher level to turn poverty alleviation from a ‘social cost’ to an ‘innovative resource’. [Method & Outcomes] This paper applies the Action Research method to propose and test the Design-driven Poverty Alleviation (DDPA) Framework, which …

Designing Adaptable Consumption: A New Practice To Foster Food System Transitions., Hannah Goss, Nynke Tromp, Rick Schifferstein

IASDR Conference Series

In recent years, more designers have been engaging in transitions for which design activity is used to develop innovations that steer change. However, little is known about how designers develop innovations to foster change along a desired transition path. In this short paper, we explore how designers can develop joint innovations that steer a transition of the Dutch food system to embrace flexibility and cater to enough. We present a new practice called Adaptable Consumption, which aims to realign food safety, quality, and sustainability. Based on our preliminary findings, we discuss how our process inspires reflections on the transition and …

Introducing Hope In Design For Health And Well-Being, Arefe Jasbi, Marikken Høiseth

IASDR Conference Series

Health and well-being are fundamental aspects of life, directly impacting the quality of life. Hope is a phenomenon that significantly relates to the quality of life. The purpose of this paper is to introduce hope in the context of design for health and well-being. By exploring the intersection of design, health, and hope, we can create outcomes that are not only functional and address immediate needs but also increase resilience and foster a sense of optimism and empowerment to users and communities. We provide reflections on how this elevation in design can cultivate strengthened communities through improved healthcare interventions.