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Implementing Transformative Education With Participatory Action Research: A Review, Niroj Dahal Nov 2023

Implementing Transformative Education With Participatory Action Research: A Review, Niroj Dahal

The Qualitative Report

I write this review of the book, Implementing Transformative Education with Participatory Action Research, for readers, writers, and novice and veteran researchers in various social sciences disciplines and educational landscapes. The book explores using Participatory Action Research (PAR) to implement transformative education. The book argues that PAR can be used to create contextualized, sustainable, and student-centered learning environments. It offers invaluable insights from experts who have actively worked on innovative approaches to school transformation. The book also provides practical guidance and research-based strategies to help scholars effectively navigate challenges and implement transformative education. Overall, the book is a valuable …


An Empirical Survey Of Peacebuilding Initiatives At The Grass Root Level: A Study Of Women, Youth, Children, And Asha Workers In Sikkim, Salvin Paul Dr. Nov 2023

An Empirical Survey Of Peacebuilding Initiatives At The Grass Root Level: A Study Of Women, Youth, Children, And Asha Workers In Sikkim, Salvin Paul Dr.

Peace and Conflict Studies Journal Conference

Peace building has become an integral part of women, youth, asha workers and civil society in Sikkim. In order to address structural violence that is deep rooted in social structures, the activities of women, youth asha workers and NGOs institutional process will provide a first hand empirical evidence of peace building is undertaken by these agencies. These presentation would examine issues and concerns of peace building that is being discussed and debated among international and local level agencies.


The Beacon, November 3, 2023, Beacon Staff Nov 2023

The Beacon, November 3, 2023, Beacon Staff

The Beacon, 2023-2024

New Month, New Ways to Celebrate; Banning books in school systems; The Rolling Stones: timelessly authentic; Heart-wrenching "Killers of the Flower Moon; Artist4Ceasfire and the art of advocacy; Duha Lee's digital design exhibit invokes joy; Students excited for NC/DC performances; NW recognizes Native American History Month; NW students give their unfiltered opinions of AI; Why are books being banned?; The joy behind Girl Dinner; Why you should be an organ donor; Raider wrestling starts season with ranks; NW esports teams with big goals this season; How does the GPAC and NAIA influence NW? Connecting Kids and College students;


The Student Movement Volume 108 Issue 7: Not Throwing Away Our Shot: Honoring Hamilton's Legacy, Anneliese Tessalee, Nick Bishop, Grace No, Madison Vath, Amelia Stefanescu, Katrina Johnson, Reagan Mccain, Andrew Francis, Melissa Moore, Brendan Oh, Abby Shim, Reagan Westerman, Robert Zhang, Nicole Compton-Gray, Katie Davis, Anna Rybachek, Rodney Bell Ii, Wambui Karanja Nov 2023

The Student Movement Volume 108 Issue 7: Not Throwing Away Our Shot: Honoring Hamilton's Legacy, Anneliese Tessalee, Nick Bishop, Grace No, Madison Vath, Amelia Stefanescu, Katrina Johnson, Reagan Mccain, Andrew Francis, Melissa Moore, Brendan Oh, Abby Shim, Reagan Westerman, Robert Zhang, Nicole Compton-Gray, Katie Davis, Anna Rybachek, Rodney Bell Ii, Wambui Karanja

The Student Movement v. 108 (2023-2024)

HUMANS

An Arboretum of Beauty, Anneliese Tessalee

Serving with All She's Got: Natalia's Mission Experience in the Dominican Republic, Nick Bishop

WAUS Fall Fundraiser, Grace No

ARTS & ENTERTAINMENT

Art: A Window Into Another Reality, Madison Vath

Filipino Art Through Filipino Eyes: Celebrating A Culture, Amelia Stefanescu

"Free-Falling Into Autumn": A Fall Playlist, Amelia Stefanescu

Upcoming Events in the Art Department, Katrina Johnson

What to do about Inhospitality?: A Review of Mitski's Newest Album, Reagan McCain

NEWS

Andrews Autumn Conference Promotes Peaceful Scientific Discourse, Andrew Francis

Honors Goes to Hamilton, Melissa Moore

Unraveling the Historical Threads: The SDA Church's Journey …


A Multi-Organ Maize Metabolic Model Connects Temperature Stress With Energy Production And Reducing Power Generation, Niaz Bahar Chowdhury, Margaret Simons- Senftle, Berengere Decouard, Isabelle Quillere, Martine Rigault, Karuna Anna Sajeevan, Bibek Acharya, Ratul Chowdhury, Bertrand Hirel, Alia Dellagi, Costas Maranas, Rajib Saha Nov 2023

A Multi-Organ Maize Metabolic Model Connects Temperature Stress With Energy Production And Reducing Power Generation, Niaz Bahar Chowdhury, Margaret Simons- Senftle, Berengere Decouard, Isabelle Quillere, Martine Rigault, Karuna Anna Sajeevan, Bibek Acharya, Ratul Chowdhury, Bertrand Hirel, Alia Dellagi, Costas Maranas, Rajib Saha

Department of Chemical and Biomolecular Engineering: Faculty Publications

Climate change has adversely affected maize productivity. Thereby, a holistic understanding of metabolic crosstalk among its organs is important to address this issue. Thus, we reconstructed the first multi-organ maize metabolicmodel, iZMA6517, and contextualized itwith heat and cold stress transcriptomics data using expression distributed reaction flux measurement (EXTREAM) algorithm. Furthermore, implementing metabolic bottleneck analysis on contextualized models revealed differences between these stresses. While both stresses had reducing power bottlenecks, heat stress had additional energy generation bottlenecks.We also performed thermodynamic driving force analysis, revealing thermodynamics-reducing power-energy generation axis dictating the nature of temperature stress responses. Thus, a temperaturetolerant maize ideotype can …


2023-11-03 Agenda Book, Morehead State University. Board Of Regents. Nov 2023

2023-11-03 Agenda Book, Morehead State University. Board Of Regents.

Morehead State Board of Regents Agenda Books and Meeting Minutes

Agenda booklet for the Board of Regents meeting of November 3, 2023 which includes the meeting minutes of August 18, 2023.


Glutamate Receptor Dysregulation And Platelet Glutamate Dynamics In Alzheimer's And Parkinson's Diseases: Insights Into Current Medications, Deepa Gautam, Ulhas Naik, Meghna Naik, Santosh Yadav, Rameshwar Nath Chaurasia, Debabrata Dash Nov 2023

Glutamate Receptor Dysregulation And Platelet Glutamate Dynamics In Alzheimer's And Parkinson's Diseases: Insights Into Current Medications, Deepa Gautam, Ulhas Naik, Meghna Naik, Santosh Yadav, Rameshwar Nath Chaurasia, Debabrata Dash

Cardeza Foundation for Hematologic Research

Two of the most prevalent neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and Parkinson's disease (PD), present significant challenges to healthcare systems worldwide. While the etiologies of AD and PD differ, both diseases share commonalities in synaptic dysfunction, thereby focusing attention on the role of neurotransmitters. The possible functions that platelets may play in neurodegenerative illnesses including PD and AD are becoming more acknowledged. In AD, platelets have been investigated for their ability to generate amyloid-ß (Aß) peptides, contributing to the formation of neurotoxic plaques. Moreover, platelets are considered biomarkers for early AD diagnosis. In PD, platelets have been studied for …


A Qualitative Study On Parenting Practices To Sustain Adolescent Health Behaviors In American Indian Families, Christine Hodgson, Dylan Decker, Teresia M O'Connor, Melanie Hingle, Francine C Gachupin Nov 2023

A Qualitative Study On Parenting Practices To Sustain Adolescent Health Behaviors In American Indian Families, Christine Hodgson, Dylan Decker, Teresia M O'Connor, Melanie Hingle, Francine C Gachupin

Children’s Nutrition Research Center Staff Publications

American Indian (AI) adolescents who practice healthy behaviors of sleep, nutrition, physical activity, and limited screen time can lower their lifetime risk of diet-sensitive disease. Little is known about how AI parenting practices influence the health behaviors of youth. The objective of this qualitative study was to explore how a group of AI parents of youths at risk of disease influenced their youth’s health behaviors after a family intervention. A secondary objective was to understand the role of AI parents in supporting and sustaining health behavior change in their youths following the intervention. Semi-structured in-depth interviews were conducted with AI …


Re-Evaluating Mobilization Practices And Their Impact On Hapis, Erin Christopher, Mary Prochaska, Luna Pierre, Lindsay Santucci, Kenny Van Ryn, Francheska Santiago Nov 2023

Re-Evaluating Mobilization Practices And Their Impact On Hapis, Erin Christopher, Mary Prochaska, Luna Pierre, Lindsay Santucci, Kenny Van Ryn, Francheska Santiago

Nursing Research and EBP Day 2023

Hospital acquired pressure injuries (HAPIs) contribute to longer length of stay, poor clinical outcomes and increased healthcare costs.

A literature review showed that the implementation of visual cues to identify patients who require assistance with mobility and positioning in addition to the implementation of scheduled turn teams could have a positive health impact for the patients at RGH and reduce HAPIs incidence. Research suggests that educating unlicensed staff to recognize patient Braden Scale scores and to provide daily care based on risk factors for skin breakdown may lead to improved clinical outcomes.


In Situ Profiling Reveals Metabolic Alterations In The Tumor Microenvironment Of Ovarian Cancer After Chemotherapy, Sara Corvigno, Sunil Badal, Meredith L Spradlin, Michael Keating, Igor Pereira, Elaine Stur, Emine Bayraktar, Katherine I Foster, Nicholas W Bateman, Waleed Barakat, Kathleen M Darcy, Thomas P Conrads, G Larry Maxwell, Philip L Lorenzi, Susan K Lutgendorf, Yunfei Wen, Li Zhao, Premal H Thaker, Michael J Goodheart, Jinsong Liu, Nicole Fleming, Sanghoon Lee, Livia S Eberlin, Anil K Sood Nov 2023

In Situ Profiling Reveals Metabolic Alterations In The Tumor Microenvironment Of Ovarian Cancer After Chemotherapy, Sara Corvigno, Sunil Badal, Meredith L Spradlin, Michael Keating, Igor Pereira, Elaine Stur, Emine Bayraktar, Katherine I Foster, Nicholas W Bateman, Waleed Barakat, Kathleen M Darcy, Thomas P Conrads, G Larry Maxwell, Philip L Lorenzi, Susan K Lutgendorf, Yunfei Wen, Li Zhao, Premal H Thaker, Michael J Goodheart, Jinsong Liu, Nicole Fleming, Sanghoon Lee, Livia S Eberlin, Anil K Sood

Faculty, Staff and Student Publications

In this study, we investigated the metabolic alterations associated with clinical response to chemotherapy in patients with ovarian cancer. Pre- and post-neoadjuvant chemotherapy (NACT) tissues from patients with high-grade serous ovarian cancer (HGSC) who had poor response (PR) or excellent response (ER) to NACT were examined. Desorption electrospray ionization mass spectrometry (DESI-MS) was performed on sections of HGSC tissues collected according to a rigorous laparoscopic triage algorithm. Quantitative MS-based proteomics and phosphoproteomics were performed on a subgroup of pre-NACT samples. Highly abundant metabolites in the pre-NACT PR tumors were related to pyrimidine metabolism in the epithelial regions and oxygen-dependent proline …


The Risk Of Bias In Validity And Reliability Studies Testing Physiological Variables Using Consumer-Grade Wearable Technology: A Systematic Review And Wear-Bot Analysis, Bryson Carrier, Jennifer Bunn, Joel D. Reece, Charli D. Aguilar, Chris Eschbach, James W. Navalta Nov 2023

The Risk Of Bias In Validity And Reliability Studies Testing Physiological Variables Using Consumer-Grade Wearable Technology: A Systematic Review And Wear-Bot Analysis, Bryson Carrier, Jennifer Bunn, Joel D. Reece, Charli D. Aguilar, Chris Eschbach, James W. Navalta

International Journal of Exercise Science: Conference Proceedings

INTRODUCTION: Wearable technology is a quickly evolving field, and new devices with new features to measure/estimate physiological variables are being released constantly. Despite their use, the validity of the devices are largely unknown to the users or researchers, and the quality of the studies that do test validity and reliability vary widely. PURPOSE: Therefore, the purpose of this systematic review was to review the current validity and reliability literature concerning consumer-grade wearable technology measurements/estimates of physiological variables during exercise. Additionally, we sought to perform risk of bias assessments utilizing the novel WEArable technology Risk of Bias and Objectivity Tool (WEAR-BOT). …


The Effect Of Ibuprofen On Thermoregulatory Responses And Gastrointestinal Distress To Exercise In Hot Environments, Alyssa Bailly, Jonathan Specht, Serena Garcia, Steven Klepacz, Suzana Andrade De Oliveira, David Lucero, Fabiano Amorim Nov 2023

The Effect Of Ibuprofen On Thermoregulatory Responses And Gastrointestinal Distress To Exercise In Hot Environments, Alyssa Bailly, Jonathan Specht, Serena Garcia, Steven Klepacz, Suzana Andrade De Oliveira, David Lucero, Fabiano Amorim

International Journal of Exercise Science: Conference Proceedings

Ibuprofen, a commonly used nonsteroidal anti-inflammatory drug (NSAID) among athletes to alleviate pain and inflammation during exercise, is hypothesized to mitigate exercise-induced increases core temperature (Tc) and improve heat tolerance during exercise in hot environments. However, its prophylactic use specially during exercise associated with heat stress may lead to harmful effects specifically inducing gastrointestinal complications such upper-GI bleeding. PURPOSE: To investigate the effect of ibuprofen on thermoregulatory responses and the occurrence of gastrointestinal symptoms to exercise in a hot environment. METHODS: In a double-blind, randomized, counterbalanced cross-over design, 6 endurance trained males and females (n=12) completed 60-minutes of treadmill running …


Phenotypic Correlations Between Enteric Methane Emissions And Feeding Behaviour Traits In Beef Cattle, Sean Crowley Nov 2023

Phenotypic Correlations Between Enteric Methane Emissions And Feeding Behaviour Traits In Beef Cattle, Sean Crowley

ORBioM (Open Research BioSciences Meeting)

Background

Animal breeding for methane mitigation offers the unique potential to make cumulative and permanent improvements, setting it apart from nutritional or management strategies that require ongoing investment. Internationally multiple phenotypes for enteric methane emissions have been defined, however the complexity of the relationship between methane and feed intake and ultimately animal performance, has meant there has been little consensus on which methane definition should be used in breeding goals.

Aims

Previous enteric methane research focused on traditional methane metrics like yield, intensity and residual emissions, leaving a gap in understanding how alternative traits, such as feeding behaviour, impact methane …


Association Between Chronic Kidney Disease And Metabolic Associated Fatty Liver Disease (Mafld): A Study Of Young Adults In The U.S., Nubaira Rizvi Nov 2023

Association Between Chronic Kidney Disease And Metabolic Associated Fatty Liver Disease (Mafld): A Study Of Young Adults In The U.S., Nubaira Rizvi

Dr. Joseph M. Moerschbaecher, III Graduate Research Day

No abstract provided.


Ethanol And Taste: A Time-Course Analysis Of Acute Ethanol Administration On Taste Receptor Expression And Taste Bud Density, Mary Catherine Dematteo Nov 2023

Ethanol And Taste: A Time-Course Analysis Of Acute Ethanol Administration On Taste Receptor Expression And Taste Bud Density, Mary Catherine Dematteo

Dr. Joseph M. Moerschbaecher, III Graduate Research Day

No abstract provided.


Effect Of Obesity And Metabolic-Related Diseases On The Risk Of Liver Disease: A Cross-Sectional Study, Masuma Mannan Nov 2023

Effect Of Obesity And Metabolic-Related Diseases On The Risk Of Liver Disease: A Cross-Sectional Study, Masuma Mannan

Dr. Joseph M. Moerschbaecher, III Graduate Research Day

No abstract provided.


Association Between Obesity And Arthritis, Krishna B. Thakkar Nov 2023

Association Between Obesity And Arthritis, Krishna B. Thakkar

Dr. Joseph M. Moerschbaecher, III Graduate Research Day

No abstract provided.


Vol.51 N.15 November 2nd 2023, Voice Media Ventures Nov 2023

Vol.51 N.15 November 2nd 2023, Voice Media Ventures

Black Voice News

No abstract provided.


Issue 430: November 2-16, 2023, The Local Voice Nov 2023

Issue 430: November 2-16, 2023, The Local Voice

The Local Voice

No abstract provided.


Comparison Of Dna Extraction Methods For The Detection Of Canned Tuna Species With Dna Mini-Barcoding, Aubrey J. Emmi, Biola Fatusin, Rosalee S. Hellberg Nov 2023

Comparison Of Dna Extraction Methods For The Detection Of Canned Tuna Species With Dna Mini-Barcoding, Aubrey J. Emmi, Biola Fatusin, Rosalee S. Hellberg

Food Science Faculty Articles and Research

Tuna is susceptible to species mislabeling due to its high demand, quick rate of production, and wide range of price points. DNA barcoding, a sequencing-based technique, allows for the detection of species mislabeling by targeting a standardized region of DNA. A mitochondrial control region (CR) DNA barcode has been found to be capable of species discrimination for tuna, but it is challenging to recover the entire DNA fragment from canned tuna. While a short fragment of CR, referred to as a “mini-barcode,” has shown some success with canned tuna species identification, more research is needed to improve identification rates. The …


Faculty Senate Chronicle November 2, 2023, Heather Loughney Nov 2023

Faculty Senate Chronicle November 2, 2023, Heather Loughney

The University of Akron Faculty Senate Chronicle

No abstract provided.


Research Outreach Interdisciplinary Activity To Classify Olive Oil Blends Integrating Multicolor Imaging, Image Processing, And Machine Learning, Allan Abraham, Kameshwaran Balachandran Nov 2023

Research Outreach Interdisciplinary Activity To Classify Olive Oil Blends Integrating Multicolor Imaging, Image Processing, And Machine Learning, Allan Abraham, Kameshwaran Balachandran

Undergraduate Research (Journal)

This outreach undergraduate research project presents a low-cost method to distinguish the quality of different olive oils. The proposed method is based on an indirect measurement of the chlorophyll molecules present when a green laser diode illuminates the oil sample. Oil blends can be classified into five classes (no olive oil, light olive oil, medium olive oil, olive oil, and extra virgin olive oil) by quantifying the ratio of the red channel versus the green channel along the laser illumination path from a color image. After labeling each oil blend, a convolutional neural network has been implemented and trained to …


Containerized Satsuma Mandarin Production Under Protective Screens As A Management Strategy, Anna Timmerman Nov 2023

Containerized Satsuma Mandarin Production Under Protective Screens As A Management Strategy, Anna Timmerman

LSU Master's Theses

Many of the world’s citrus growing regions are experiencing challenges related to citrus greening, also known as Huanglongbing (HLB) caused by the presumed bacterial agent Candidatus Liberibacter spp. HLB is vectored by the Asian citrus psyllid (Diaphorina citri) and through propagation of infected citrus material. HLB impacts tree health as well as fruit development, ripening, and quality of the resulting citrus fruit, often leading to an unmarketable product. Producers are growing citrus in high density orchards underneath protective screening material that excludes the Asian citrus psyllid, preventing new HLB infections. Four ultra-high containerized tree spacings of 2 feet …


The Current - Volume 34 Issue 5, Nova Southeastern University Nov 2023

The Current - Volume 34 Issue 5, Nova Southeastern University

Student Newspapers

No abstract provided.


Associations Between Rest-Activity Rhythms And Liver Function Tests: The Us National Health And Nutrition Examination Survey, 2011-2014, Chris Ho Ching Yeung, Cici Bauer, Qian Xiao Nov 2023

Associations Between Rest-Activity Rhythms And Liver Function Tests: The Us National Health And Nutrition Examination Survey, 2011-2014, Chris Ho Ching Yeung, Cici Bauer, Qian Xiao

Faculty, Staff and Student Publications

Liver functions are regulated by the circadian rhythm; however, whether a weakened circadian rhythm is associated with impaired liver function is unclear. This study aims to investigate the association of characteristics of rest-activity rhythms with abnormal levels of biomarkers of liver function. Data were obtained from the National Health and Nutrition Examination Survey 2011-2014. Seven rest-activity rhythm parameters were derived from 24 h actigraphy data using the extended cosine model and non-parametric methods. Multiple logistic regression and multiple linear regression models were used to assess the associations between rest-activity rhythm parameters and alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase …


Hospital Development Of A Hybrid Emergency Department - Inpatient Care Observation Unit, Anna Powell, Paul Clark Rn, Phd, Ma, Faen, Karan Shah Nov 2023

Hospital Development Of A Hybrid Emergency Department - Inpatient Care Observation Unit, Anna Powell, Paul Clark Rn, Phd, Ma, Faen, Karan Shah

Faculty and Staff Scholarship

Introduction: This project aimed to design and implement an emergency department-managed observation unit that improves inpatient bed and emergency department stretcher capacity, decreases observation patient length of stay, earns high patient satisfaction scores, and generates a positive fiscal impact on the organization.

Methods: This quality improvement project followed a 1-group, pre- and postprogram implementation design.

Results: In the first year of operations, 40% of the total observation patients treated in this hospital were managed in the new observation unit. Emergency department observation unit length of stay across all patient complaints was half of the average length of stay for observation …


Conformational Ensemble-Dependent Lipid Recognition And Segregation By Prenylated Intrinsically Disordered Regions In Small Gtpases, Mussie K Araya, Alemayehu A Gorfe Nov 2023

Conformational Ensemble-Dependent Lipid Recognition And Segregation By Prenylated Intrinsically Disordered Regions In Small Gtpases, Mussie K Araya, Alemayehu A Gorfe

Faculty, Staff and Student Publications

We studied diverse prenylated intrinsically disordered regions (PIDRs) of Ras and Rho family small GTPases using long timescale atomistic molecular dynamics simulations in an asymmetric model membrane of phosphatidylcholine (PC) and phosphatidylserine (PS) lipids. Here we show that conformational plasticity is a key determinant of lipid sorting by polybasic PIDRs and provide evidence for lipid sorting based on both headgroup and acyl chain structures. We further show that conformational ensemble-based lipid recognition is generalizable to all polybasic PIDRs, and that the sequence outside the polybasic domain (PBD) modulates the conformational plasticity, bilayer adsorption, and interactions of PIDRs with membrane lipids. …


Incidence And Risk Factors For Pneumonitis Associated With Checkpoint Inhibitors In Advanced Non-Small Cell Lung Cancer: A Single Center Experience, Mehmet Altan, Felipe Soto, Linda L Zhong, Fechukwu O Akhmedzhanov, Nathaniel R Wilson, Abdulrazzak Zarifa, Aya A Albittar, Vincent Yang, Jeff Lewis, Waree Rinsurongkawong, J Jack Lee, Vadeerat Rinsurongkawong, Jianjun Zhang, Don L Gibbons, Ara A Vaporciyan, Kristofer Jennings, Fareed Khawaja, Saadia A Faiz, Vickie R Shannon, Girish Shroff, Myrna C B Godoy, Naval G Daver, Saumil Gandhi, Tito R Mendoza, Aung Naing, Carrie Daniel-Macdougall, John V Heymach, Ajay Sheshadri Nov 2023

Incidence And Risk Factors For Pneumonitis Associated With Checkpoint Inhibitors In Advanced Non-Small Cell Lung Cancer: A Single Center Experience, Mehmet Altan, Felipe Soto, Linda L Zhong, Fechukwu O Akhmedzhanov, Nathaniel R Wilson, Abdulrazzak Zarifa, Aya A Albittar, Vincent Yang, Jeff Lewis, Waree Rinsurongkawong, J Jack Lee, Vadeerat Rinsurongkawong, Jianjun Zhang, Don L Gibbons, Ara A Vaporciyan, Kristofer Jennings, Fareed Khawaja, Saadia A Faiz, Vickie R Shannon, Girish Shroff, Myrna C B Godoy, Naval G Daver, Saumil Gandhi, Tito R Mendoza, Aung Naing, Carrie Daniel-Macdougall, John V Heymach, Ajay Sheshadri

Faculty, Staff and Student Publications

INTRODUCTION: Immune checkpoint inhibitor (ICI) pneumonitis causes substantial morbidity and mortality. Estimates of real-world incidence and reported risk factors vary substantially.

METHODS: We conducted a retrospective review of 419 patients with advanced non-small cell lung cancer (NSCLC) who were treated with anti-PD-(L)1 with or without anti-CTLA-4 therapy. Clinical, imaging, and microbiological data were evaluated by multidisciplinary adjudication teams. The primary outcome of interest was grade ≥2 (CTCAEv5) pneumonitis. Clinicopathologic variables, tobacco use, cancer therapies, and preexisting lung disease were assessed for univariate effects using Cox proportional hazards models. We created multivariate Cox proportional hazards models to assess risk factors for …


Tfeb And Tfe3 Control Glucose Homeostasis By Regulating Insulin Gene Expression, Adrien Pasquier, Nunzia Pastore, Luca D'Orsi, Rita Colonna, Alessandra Esposito, Veronica Maffia, Rossella De Cegli, Margherita Mutarelli, Susanna Ambrosio, Gennaro Tufano, Antonio Grimaldi, Marcella Cesana, Davide Cacchiarelli, Nathalie Delalleau, Gennaro Napolitano, Andrea Ballabio Nov 2023

Tfeb And Tfe3 Control Glucose Homeostasis By Regulating Insulin Gene Expression, Adrien Pasquier, Nunzia Pastore, Luca D'Orsi, Rita Colonna, Alessandra Esposito, Veronica Maffia, Rossella De Cegli, Margherita Mutarelli, Susanna Ambrosio, Gennaro Tufano, Antonio Grimaldi, Marcella Cesana, Davide Cacchiarelli, Nathalie Delalleau, Gennaro Napolitano, Andrea Ballabio

Duncan NRI Faculty and Staff Publications

To fulfill their function, pancreatic beta cells require precise nutrient-sensing mechanisms that control insulin production. Transcription factor EB (TFEB) and its homolog TFE3 have emerged as crucial regulators of the adaptive response of cell metabolism to environmental cues. Here, we show that TFEB and TFE3 regulate beta-cell function and insulin gene expression in response to variations in nutrient availability. We found that nutrient deprivation in beta cells promoted TFEB/TFE3 activation, which resulted in suppression of insulin gene expression. TFEB overexpression was sufficient to inhibit insulin transcription, whereas beta cells depleted of both TFEB and TFE3 failed to suppress insulin gene …


The Prognostic Role Of Platelet-To-Lymphocyte Ratio In Acute Coronary Syndromes: A Systematic Review And Meta-Analysis, Michal Pruc, Frank William Peacock, Zubaid Rafique, Damian Swieczkowski, Krzysztof Kurek, Monika Tomaszewska, Burak Katipoglu, Maciej Koselak, Basar Cander, Lukasz Szarpak Nov 2023

The Prognostic Role Of Platelet-To-Lymphocyte Ratio In Acute Coronary Syndromes: A Systematic Review And Meta-Analysis, Michal Pruc, Frank William Peacock, Zubaid Rafique, Damian Swieczkowski, Krzysztof Kurek, Monika Tomaszewska, Burak Katipoglu, Maciej Koselak, Basar Cander, Lukasz Szarpak

Faculty, Staff and Students Publications

This study aimed to investigate the potential prognostic role of the platelet-to-lymphocyte (PLR) ratio in patients presenting with suspected acute coronary syndromes (ACS). A systematic search of PubMed Central, Scopus, EMBASE, and the Cochrane Library from conception through 20 August 2023 was conducted. We used odds ratios (OR) as the effect measure with 95% confidence intervals (CIs) for dichotomous data and mean differences (MD) with a 95% CI for continuous data. If I2 was less than 50% or the p value of the Q tests was less than 0.05, a random synthesis analysis was conducted. Otherwise, a fixed pooled meta-analysis …