Digital Commons Network^™

Microbiota Dynamics, Metabolic And Immune Interactions In The Cervicovaginal Environment And Their Role In Spontaneous Preterm Birth, Stanely Onyango, Jia Dai Mi, Anjela Koech, Patricia Okiro, Marleen Temmerman, Peter Von Dadelszen, Rachel Marie Tribe, Geoffrey Omuse

Pathology, East Africa

Differences in the cervicovaginal microbiota are associated with spontaneous preterm birth (sPTB), a significant cause of infant morbidity and mortality. Although establishing a direct causal link between cervicovaginal microbiota and sPTB remains challenging, recent advancements in sequencing technologies have facilitated the identification of microbial markers potentially linked to sPTB. Despite variations in findings, a recurring observation suggests that sPTB is associated with a more diverse and less stable vaginal microbiota across pregnancy trimesters. It is hypothesized that sPTB risk is likely to be modified via an intricate host-microbe interactions rather than due to the presence of a single microbial taxon …

Fair Canonical Correlation Analysis, Zhuoping Zhou, Davoud Ataee Tarzanagh, Bojian Hou, Boning Tong, Jia Xu, Yanbo Feng, Qi Long, Li Shen

Faculty, Staff and Student Publications

This paper investigates fairness and bias in Canonical Correlation Analysis (CCA), a widely used statistical technique for examining the relationship between two sets of variables. We present a framework that alleviates unfairness by minimizing the correlation disparity error associated with protected attributes. Our approach enables CCA to learn global projection matrices from all data points while ensuring that these matrices yield comparable correlation levels to group-specific projection matrices. Experimental evaluation on both synthetic and real-world datasets demonstrates the efficacy of our method in reducing correlation disparity error without compromising CCA accuracy.

Oral Glucose Tolerance Test In Pregnancy And Subsequent Maternal Hypertension, Maged M Costantine, Madeline Murguia Rice, Mark B Landon, Michael W Varner, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Alan T N Tita, John M Thorp, Edward K Chien, Alan M Peaceman, Sean C Blackwell

Faculty, Staff and Student Publications

Objective: The aim of the study is to evaluate whether values and the shape of the glucose curve during the oral glucose tolerance test (OGTT) in pregnancy identify women at risk of developing hypertension (HTN) later in life.

Study design: This category includes the secondary analysis of a follow-up from a mild gestational diabetes mellitus (GDM) study that included a treatment trial for mild GDM (n = 458) and an observational cohort of participants with abnormal 1-hour glucose loading test only (normal OGTT, n = 430). Participants were assessed at a median of 7 (IQR 6-8) years after their …

Evaluating Strength Of Recommendations For Commonly Administered Medications In Lactating Women, Yevgenia Y Fomina, John J Byrne, Catherine Y Spong

Faculty, Staff and Student Publications

Objective: To characterize the data on medications for lactating people in the LactMed database and evaluate the strength of the data for the most commonly administered medications in lactating women.

Methods: A retrospective analysis of all medications in the LactMed database in 12/2020 was performed. Each medication was classified into one of three categories: absent data, minimal-moderate data, strong data pertaining to safety in lactation. No data was defined as no available research studies associated with the medication. Minimal-moderate data was defined as absent research studies in one or more of the four LactMed categories: maternal drug levels, infant drug …

Systematic Analysis Of Proximal Midgut- And Anorectal-Originating Contractions In Larval Zebrafish Using Event Feature Detection And Supervised Machine Learning Algorithms, Ryan M Cassidy, Erika M Flores, Anh K Trinh Nguyen, Sai S Cheruvu, Rosa A Uribe, Anne Marie Krachler, Max A Odem

Faculty, Staff and Student Publications

Background: Zebrafish larvae are translucent, allowing in vivo analysis of gut development and physiology, including gut motility. While recent progress has been made in measuring gut motility in larvae, challenges remain which can influence results, such as how data are interpreted, opportunities for technical user error, and inconsistencies in methods.

Methods: To overcome these challenges, we noninvasively introduced Nile Red fluorescent dye to fill the intraluminal gut space in zebrafish larvae and collected serial confocal microscopic images of gut fluorescence. We automated the detection of fluorescent-contrasted contraction events against the median-subtracted signal and compared it to manually annotated gut contraction …

Does Maternal Mental Health (Anxiety And Depression) Negatively Impact Exclusive And Continued Breastfeeding Practices?, Smriti Neupane

UNLV Theses, Dissertations, Professional Papers, and Capstones

Exclusive and continued breastfeeding practices are the optimal source of nutrition for an infant's well-being, cognitive growth, and development and have positive health outcomes for the mother too. Anxiety and depression are common perinatal mental health conditions associated with early breastfeeding interruption. However, Nevada lacks data on perinatal mental health and its influence on breastfeeding practices. The objective of this study was to assess whether maternal mental health (anxiety and depression) impacts exclusive and continued breastfeeding practices in Clark County, Nevada. A cross-sectional survey was conducted with 358 mothers having children 0-23 months old and residing in Clark County, Nevada. …

Physiological And Molecular Bases Of The Boron Deficiency Response In Tomatoes, Junjun Li, Huihui Fan, Qianqian Song, Lili Jing, Hao Yu, Ruishan Li, Ping Zhang, Fei Liu, Weimin Li, Liangliang Sun, Jin Xu

Faculty, Staff and Student Publications

Boron is an essential microelement for plant growth. Tomato is one of the most cultivated fruits and vegetables in the world, and boron deficiency severely inhibits its yield and quality. However, the mechanism of tomato in response to boron deficiency remains largely unclear. Here, we investigated the physiological and molecular bases of the boron deficiency response in hydroponically grown tomato seedlings. Boron deficiency repressed the expression of genes associated with nitrogen metabolism, while it induced the expression of genes related to the pentose phosphate pathway, thereby altering carbon flow to provide energy for plants to cope with stress. Boron deficiency …

Chinatown Outreach - Targeted Resources For The Unhoused Population, Jesus Herrera

Capstone Projects and Master's Theses

Addressing housing insecurities is one of The Epicenter’s pillars while utilizing a new federal grant. The Youth Homelessness Demonstration Program is the division implementing the project that will consist of outreach through a mobilization team. Housing insecurities are not only a city issue but a statewide one and YHDP is designed to help reduce those insecurities and improve a client’s quality of life while providing food, clothing, hygiene packs, and resource information to improve their livelihood. To assess the effectiveness of our deliverables it consisted of tallying, informal dialogues, and data analysis. The most important measure is that we were …

Prevalence Of Diabetes In Monterey County, Irenee Judith Flores-Morgado

Capstone Projects and Master's Theses

Aspire Health is a nonprofit organization that collaborates with community partners to improve the health and well-being for residents in Monterey County. In Monterey County, about 50% of the adult population is affected with type 2 diabetes and prediabetes. Aspire Health provides a free diabetes education module to students in Monterey County grade K-12, where they learn about diabetes and how to make healthier lifestyle choices. The project consisted of launching a texting feature that provided resources on diabetes. The purpose was to raise awareness and education about diabetes in Monterey County by providing local resources on diabetes with the …

Fall Collection Drive For Homeless Individuals In Monterey County, Xitlali Amaya Romero

Capstone Projects and Master's Theses

Monterey County has a high rate of homeless individuals. CSUMB Community Health Engagement (CHE) in Salinas, CA, provides various services and resources to homeless individuals to help meet their basic needs. A collection drive was a resourceful project implemented to allocate items to be donated to homeless individuals during CHE's outreach efforts through different encampments. The intern's implementation methods used various methods to spread the word about the event, including creating a flyer, using media, and networking. The expected outcome was to have people donate various items to give back to homeless individuals during CHE's outreach efforts or tabling events. …

Food Insecurity At Los Abuelitos, Rosalina Duran

Capstone Projects and Master's Theses

Food insecurity among the senior population is a social problem that can cause malnutrition, chronic conditions, and death. CHISPA Housing Management and Community Services is a non-profit organization that builds low-income senior housing in Monterey County and provides senior hot lunches to its residents. The causes of food insecurity are a lack of income, chronic conditions, and transportation issues. The consequences of food insecurity are the deterioration of their physical and mental health. This capstone project is an assessment that consists of gathering data on the residents who reside at the Los Abuelitos Townhome housing rather than taking advantage of …

Stereotactic Body Radiotherapy With Or Without Selective Dismutase Mimetic In Pancreatic Adenocarcinoma: An Adaptive, Randomised, Double-Blind, Placebo-Controlled, Phase 1b/2 Trial, Cullen M Taniguchi, Jessica M Frakes, Todd A Aguilera, Manisha Palta, Brian Czito, Manoop S Bhutani, Lauren E Colbert, Joseph Abi Jaoude, Vincent Bernard, Shubham Pant, Ching-Wei D Tzeng, Dae Won Kim, Mokenge Malafa, James Costello, Geena Mathew, Neal Rebueno, Eugene J Koay, Prajnan Das, Ethan B Ludmir, Matthew H G Katz, Robert A Wolff, Sam Beddar, Gabriel O Sawakuchi, Shalini Moningi, Rebecca S Slack Tidwell, Ying Yuan, Peter F Thall, Robert A Beardsley, Jon Holmlund, Joseph M Herman, Sarah E Hoffe

Faculty, Staff and Student Publications

BACKGROUND: Stereotactic body radiotherapy (SBRT) has the potential to ablate localised pancreatic ductal adenocarcinoma. Selective dismutase mimetics sensitise tumours while reducing normal tissue toxicity. This trial was designed to establish the efficacy and toxicity afforded by the selective dismutase mimetic avasopasem manganese when combined with ablative SBRT for localised pancreatic ductal adenocarcinoma.

METHODS: In this adaptive, randomised, double-blind, placebo-controlled, phase 1b/2 trial, patients aged 18 years or older with borderline resectable or locally advanced pancreatic cancer who had received at least 3 months of chemotherapy and had an Eastern Cooperative Oncology Group performance status of 0-2 were enrolled at six …

Kinome Profiling Identifies Mark3 And Stk10 As Potential Therapeutic Targets In Uveal Melanoma, Usman Baqai, Alison M Kurimchak, Isabella V Trachtenberg, Timothy J Purwin, Jelan I Haj, Anna Han, Kristine Luo, Nikole Fandino Pachon, Angela Jeon, Vivian Chua, Michael A Davies, J Silvio Gutkind, Jeffrey L Benovic, James S Duncan, Andrew E Aplin

Faculty, Staff and Student Publications

Most uveal melanoma cases harbor activating mutations in either GNAQ or GNA11. Despite activation of the mitogen-activated protein kinase (MAPK) signaling pathway downstream of Gαq/11, there are no effective targeted kinase therapies for metastatic uveal melanoma. The human genome encodes numerous understudied kinases, also called the "dark kinome". Identifying additional kinases regulated by Gαq/11 may uncover novel therapeutic targets for uveal melanoma. In this study, we treated GNAQ-mutant uveal melanoma cell lines with a Gαq/11 inhibitor, YM-254890, and conducted a kinase signaling proteomic screen using multiplexed-kinase inhibitors followed by mass spectrometry. We observed downregulated expression and/or activity of 22 kinases. …

Delineating The Impact Of Vascular Smooth Muscle Cell Abca1/G1 And Mir-33a Expression On Atherosclerosis, Olanrewaju Oladosu

All Dissertations

Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide due to being the predominant factor in heart attack and stroke deaths. Atherosclerotic cardiovascular disease is caused by cholesterol accumulating in arteries. It is historically thought that the cell type most responsible for causing atherosclerosis via excessive cholesterol accumulation is intimal monocyte-derived macrophages. However, macrophage-like cells (MLC) of vascular smooth muscle cell (VSMC) origin have now been proposed as another cell type to trigger atherosclerosis, since VSMC cholesterol accumulation results in these cells to trans-differentiate into a MLC phenotype. Three major genes involved in cholesterol metabolism are ABCA1, ABCG1, and …

Place-Based Philanthropy With An Adaptive Lens: Actively Balancing Community-Driven And Foundation-Driven Orientations, Douglas Easterling, Tanya Beer, Kristen Burwell Naney, Mina Silberberg, Laura Gerald, Adam Linker

The Foundation Review

With place-based philanthropy, a foundation provides extensive, long-term support for a comprehensive mix of programs within specific communities, with the expectation that this will produce benefits at a communitywide level. One of the key questions in designing a place-based initiative is how much the foundation will control local decision-making.

In some initiatives, the foundation dictates the issues that community groups must address and/or the nature of the planning process that will be used to develop solutions. This sometimes produces ineffective or irrelevant solutions. In contrast, other initiatives allow local groups considerable discretion in naming the issues and choosing the solutions, …

Understanding The Interaction Of Environmental Contaminants With Polystyrene Nanoparticles And Dna Using Nuclear Magnetic Resonance Spectroscopy And Density Functional Theory, Saduni Arachchi

All Dissertations

The objective of the thesis is to study the effect of environmental pollutants on polystyrene nanoparticles and biomolecules. This is done in two different techniques, particularly NMR and density functional theory. In this thesis, we use a combination of 1H NMR, Saturation-Transfer Difference (STD) NMR and relaxation experiments to study the interactions, kinetics and dynamics of antibiotics with polystyrene nanoparticles. (PS NPs) Density functional theory (DFT) is used to study the binding of commonly used non-oxidative hair dyes to biomolecules (DNA and amino acids) and PS particles.

Enhanced Wound Care Identification And Intervention, Melissa Faura Rd, Ldn, Rachel Geosits Ms, Rdn, Cnsc, Ldn, Ann Flickinger Ms, Rd, Ldn

Clinical Nutrition Service

No abstract provided.

A 2-Tiered Educational Program To Enhance Nutrition Knowledge, Confidence And Application Among Medical Residents, Kimberly Cephas Ms, Rd, Cnsc, Ldn, Jacqueline Labatch Rd, Cnsc, Ldn, Renee Selby Rd, Cnsc, Ldn

Clinical Nutrition Service

No abstract provided.

Assessing The Barriers To Utilizing Length Boards In A Level Iv Neonatal Intensive Care Unit, Heather Kistler Rd, Csp, Ldn, Kristi L. Ruth Rd, Cnsc, Ldn, Laura Kurtz Ms, Rd, Ldn

Clinical Nutrition Service

No abstract provided.

Estimating The Chemical Composition Of Secondary Compounds Of Iraqi Wild Agaricus Bellaniae Characterized Morphologically And Genetically, Ziena M. Abdul-Qader, Rukiabaa A. Chechan, Sudad K.M. Al-Taweel

Baghdad Science Journal

This study, which is considered the first of its kind in the world and the Arab homeland, was carried out in the laboratory of mushroom production belonging to the Medicinal Plant Unit/ College Of Agricultural Engineering Sciences/ University of Baghdad during the period from July 21, 2016, to December 30, 2018, aiming to isolate and purify the mycelium of the wild isolation in addition to the genetic and morphological identification of the mushroom Agaricus bellaniae. The obtained pure isolation was tagged in the American National Center for Biotechnology Information (NCBI) with symbol MF987843.1, thus Iraq would be the second country …

Control Pepper Fusarium Wilting By Biocontrol Agent Trichoderma Harzianum And Chelated Iron Fe-Eddha, Ali Nasser Ali Al-Aamel, Bushra Subair Abdulsada Al-Maliky

Baghdad Science Journal

Sweet pepper (Capsicum annuum L.) is an economically important vegetable crop. Wilt disease caused by Fusarium oxysporum f. sp. capsici is a specific pathogen that affects the pepper. Four isolates of F. oxysporum f. sp. capsici Fo3, Fo6, Fo7 and Fo8 were obtained from diseased pepper plants that were collected from different pepper fields in Baghdad. Fo6 isolate that has high pathogenicity to pepper seeds, Trichoderma harzianum (Th) was tested in vitro against F. oxysporum f. sp. capsici showed a high inhibition rate for the isolate Fo6, the concentration of chelated iron Fe-EDDHA 0.5% reduced the radial growth of Fo6 …

Taxonomic And Morphological Studies On The Genus Chrotogonus Serville, 1838 (Pyrgomorphidae: Orthoptera) From Pakistan, With Reference To Their Habitats, Samiullah Soomro, Riffat Sultana

Baghdad Science Journal

Species of genus Chrotogonus (surface grasshoppers) are phytophagous and damaging to various economical important plants in their seedling stages. In order to know the biodiversity of surface grasshoppers, the detailed study has been conducted from four provinces of Pakistan. During this study, biodiversity, taxonomy, diagnosis, morphometric analysis, habitat, global distribution, and remarks of each species have been described. Total of 826 specimens were collected and sorted out into three species and three subspecies: C. (Chrotogonus) homalodemus homalodemus (Blanchard, 1836), C. (Chrotogonus) homalodemus (Blanchard, 1836), C. (Chrotogonus) trachypterus trachypterus (Blanchard, 1836), C. (Chrotogonus) trachypterus robertsi Kirby, 1914, C. (Chrotogonus) trachypterus (Blanchard, …

A Study Of Policies And Responses To Chronically Absent Students In Illinois High Schools In The Four Southern Most Regions Of The Illinois Associaiton Of School Administrators, Charles Shain Crank

Dissertations

No abstract

Utilizing The Genetic Potentials Of Traditional Rice Varieties And Conserving Rice Biodiversity With System Of Rice Intensification Management, Yheni Dwiningsih

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

The genetic potentials of rice cultivars will need to be expressed to their fullest if global rice production is to be expanded enough by 2050 to meet the increased demand of the expanding population while the availability of land and water per capita dwindles. New and ‘improved’ rice varieties have contributed greatly to increased production over the past 50 years, but the rate of rice yield increase based on genetic changes has declined in recent decades compared with the early years of the Green Revolution. In fact, many rice consumers continue to prefer to consume ‘traditional’ rice varieties (referred to …

Projecting, Persuading, & Protecting: A Mixed Methods Analysis Of Adult Children’S Predictions Of Parents’ Quality-Of-Life Valuations In Serious Illness States, Jessica Hahne

Arts & Sciences Graduate Student Theses and Dissertations

Older adults often face complex serious illness decisions and involve their adult children as shared or surrogate decision makers. However, previous research asking family members to predict older adults’ treatment preferences in serious illness situations typically shows poor concordance with older adults’ actual preferences. In the current mixed methods analysis, we surveyed older adults (n = 38) on their health state valuations in five serious illness scenarios. Two of their adult children (n = 76) predicted their parent’s preferences. Families also participated in a semi-structured conversation to discuss their preferences and predictions. Quantitative analyses showed that parents’ average valuations were …

High Stakes, Bad Odds: Health Laws And The Revived Federalism Revolution, Nicole Huberfeld

Faculty Scholarship

The Supreme Court’s 2021 term produced a remarkable number of blockbuster decisions, nearly hiding an underlying federalism agenda that surfaced in health care, reproductive rights, administrative law, and public health related domains. Health law has been a vehicle for constitutional change before, but the stakes for older laws, most of which rely on states to accomplish national goals, have been raised. The Court has doubled down on interpretive methods that limit governmental power, using formalist tools like clear statement rules that demand specificity and offer little deference to lawmakers or regulators. These rules have constitutional dimensions, including separation of powers …

Physiological And Biomechanical Response To Indoor Cycling With And Without The Ability To Sway, Alina P. Swafford

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Bicycles have been around since the early 19th century. Since the invention of the bicycle, it has taken on several purposes. People have used bicycles as a means of transportation, leisure, exercise, and sport. The number of individuals who participate in a cycling event per year has increased. With the increase in popularity, research related to cycling has also increased. Research related to the physiology and biomechanics of cycling are of particular areas of interest. Balance is a crucial component of understanding why we cycle a certain way. Some research has labeled balancing on a bicycle as cycling sway. …

Placental Co-Culture Model Reveals Listeria Monocytogenes Utilization Of Monocytes For Vertical Transmission, Breanna Mackenzie Amelunke

Online Theses and Dissertations

Listeria monocytogenes is an opportunistic pathogen that can cross the protective placental barrier and infect the fetus, leading to congenital disabilities or death. Extracellular L. monocytogenes infection of the placenta has been well studied; however, the bacteria have not been observed translocating this barrier intracellularly. As an intracellular pathogen, L. monocytogenes could infect phagocytic cells that can be transported across the placental barrier. A novel cell co-culture system comprised of BeWo and HPVEC cell lines was established to model the human placental barrier. Barrier integrity was confirmed using immunostaining of tight junctions and a FITC-dextran permeability assay. The model was …

Climate Change And The Shifting Geography Of Coral-Reef Development, Victor Rodriguez-Ruano

Theses and Dissertations

Coral-reef development is modulated by growth processes that deposit calcium carbonate onto the reef, such as calcification, and destructive processes that remove calcium carbonate from the reef, such as bioerosion. Wherever calcification rates exceed bioerosion rates, there is a net accretion of the reef through time, but where bioerosion rates exceed calcification rates, there is a net destruction of the reef through time. A reef’s framework is the legacy of the interaction of these processes throughout a reef’s history. Studying the fossil frameworks of reefs can shed light on the environmental factors that have controlled reef development in the past, …

The Therapeutic Role Of Lm11a-31 (A P75ntr Modulator) In The Outcome Of Ischemic Stroke And Hiv-1 Pathogenesis, Golnoush Mirzahosseini

Theses and Dissertations (ETD)

The objective of this research project is to explore the potential therapeutic role of LM11A-31 in both ischemic stroke and human immunodeficiency virus-1 (HIV-1) infection. There are limited treatment options for ischemic stroke, with tissue plasminogen activator (tPA) being the only effective medication and a narrow administration window, which is also accompanied with the high incidence of ischemic stroke in HIV-1 infected individuals. Therefore, it is critical to explore an effective therapeutic agent to address the urgent medical need. LM11A-31 is a p75 neurotrophin receptor (p75NTR) modulator and is orally bioavailable, and it can penetrate the intact blood-brain barrier (BBB). …