Digital Commons Network^™

Developing And Evaluating The Usability Of A Web-Based Diabetic Retinopathy Health Education Program For Patients With Type 2 Diabetes Mellitus, Rif’Atunnailah Mat Isa, Mei Chan Chong, Wan Ling Lee, Tajunisah Iqbal, Mardiana Mansor, Airul Azizan Zainudin

Saudi Medical Journal

Objectives: To describe the development of a webpage based on the Intervention Mapping (IM) protocol and usability testing of the Diabetic Retinopathy Health Education Profram (DRHEP). Methods: The mixed methods pilot feasibility study was carried out between April and September 2021, involving 16 patients with type 2 diabetes mellitus and 5 experts. The usability score was rated according to the System Usability Scale (SUS). Results: The average SUS score by the experts was 88. The patients gave a higher score of 85 for SUS, with 58 as the lowest. The average SUS score was 72. The findings indicate that the …

The Determinants Of Creator Performance On Creative Content Platforms: Evidence From Xiaohongshu And Bilibili, Caijun Xu

Dissertations and Theses Collection (Open Access)

Content creation platforms, including Douyin, Kuaishou, Xiaohongshu, and Bilibili, have emerged as significant drivers of employment and economic growth within the digital economy. These platforms invigorate online engagement and offline consumption, serving as vital conduits that merge China’s digital and real economies. Currently, China boasts over 10 million active content creators on its leading platforms, although their earnings are markedly uneven. While some top-tier creators garner substantial profits, the majority in the mid to lower tiers grapple with profit generation and encounter challenges in enhancing their creative performance. Against this background, this study delves into the antecedents of creative performance. …

Cooperative Extension Programming For Early Care And Education Professionals During The First Year Of The Covid-19 Pandemic: Evidence From A National Survey Of Extension Systems, Katherine Speirs, Azriella Friedman, Courtney Luecking, Kyleigh Brown

Journal of Human Sciences and Extension

Cooperative Extension Systems (CESs) provide programming to early care and education (ECE) professionals. The COVID-19 pandemic significantly impacted the needs of ECE professionals. The purpose of this study was to document how CESs helped ECE professionals respond to the pandemic during its first year and how Extension programming was altered in response to the pandemic. Between March and June 2020, representatives from all 87 CESs in the 50 U.S. states; Washington, DC; and six U.S. territories were invited to complete an online survey that included six questions about the pandemic. We received responses from 43 CESs (49% response rate). The …

Examining College Students’ Attitudes Toward Poverty During The Adult Role Of The Community Action Poverty Simulation, Jessica M. Parks, Portia Johnson, Diann C. Moorman, Sheri Worthy, Leigh Anne Aaron

Journal of Human Sciences and Extension

Family and Consumer Sciences (FCS) and Extension professionals need to understand the lived experience of poverty because it affects every aspect of an individual’s life. Poverty is related to inadequate nutrition and food insecurity, lack of access to health care, insufficient child care, unsafe neighborhoods, lack of affordable housing, under-resourced schools, and a lower quality of life. Attitudes toward poverty vary widely among Americans and can be categorized as either internal/individual attributions (e.g., laziness, welfare dependency, etc.) or systemic/structural attributions (e.g., unemployment, inflation, etc.). Individuals holding internal attributions toward poverty are more likely to have negative feelings toward impoverished individuals. …

Kinome Profiling Identifies Mark3 And Stk10 As Potential Therapeutic Targets In Uveal Melanoma, Usman Baqai, Alison M. Kurimchak, Isabella Trachtenberg, Timothy J. Purwin, Jelan I. Haj, Anna Han, Kristine Luo, Nikole Fandino Pachon, Angela Jeon, Vivian Chua, Michael A. Davies, J Silvio Gutkind, Jeffrey L. Benovic, James S. Duncan, Andrew E. Aplin

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Most uveal melanoma cases harbor activating mutations in either GNAQ or GNA11. Despite activation of the mitogen-activated protein kinase (MAPK) signaling pathway downstream of Gαq/11, there are no effective targeted kinase therapies for metastatic uveal melanoma. The human genome encodes numerous understudied kinases, also called the "dark kinome". Identifying additional kinases regulated by Gαq/11 may uncover novel therapeutic targets for uveal melanoma. In this study, we treated GNAQ-mutant uveal melanoma cell lines with a Gαq/11 inhibitor, YM-254890, and conducted a kinase signaling proteomic screen using multiplexed-kinase inhibitors followed by mass spectrometry. We observed downregulated expression and/or activity of 22 kinases. …

Correlations Between Educational Struggle, Toxic Sites By School District And Demographic Variables, With Geographical Information System Projections, Junu Shrestha, Raihan K. Khan, Shane Mcclintock, John Degroote, Catherine L. Zeman

Faculty Publications

This correlational study associated data on children enrolled in individualized educational plans in their K-12 schools (IEP) and an algorithm-calculated score of neurotoxins at contaminated sites located in each school district. The study also mapped and projected the correlations using Geographical Information System (GIS) technology. These data were populated in ArcMap 10.5 (a GIS software) for generating maps and data to conduct geospatial analysis. A total of 1 Superfund site and 39 CERCLA sites were identified as contaminated sites for this analysis. The majority of contaminants were heavy metals such as lead, arsenic, mercury, and cadmium. The mean toxic score …

Design, Analysis, And Interpretation Of Treatment Response Heterogeneity In Personalized Nutrition And Obesity Treatment Research, Roger S Zoh, Bridget H Esteves, Xiaoxin Yu, Amanda J Fairchild, Ana I Vazquez, Andrew G Chapple, Andrew W Brown, Brandon George, Derek Gordon, Douglas Landsittel, Gary L Gadbury, Greg Pavela, Gustavo De Los Campos, Luis M Mestre, David B Allison

Children’s Nutrition Research Center Staff Publications

It is increasingly assumed that there is no one-size-fits-all approach to dietary recommendations for the management and treatment of chronic diseases such as obesity. This phenomenon that not all individuals respond uniformly to a given treatment has become an area of research interest given the rise of personalized and precision medicine. To conduct, interpret, and disseminate this research rigorously and with scientific accuracy, however, requires an understanding of treatment response heterogeneity. Here, we define treatment response heterogeneity as it relates to clinical trials, provide statistical guidance for measuring treatment response heterogeneity, and highlight study designs that can quantify treatment response …

Comment On Marsigliante Et Al Effects On Children's Physical And Mental Well-Being Of A Physical-Activity-Based School Intervention Program: A Randomized Study, Raphiel Murden, Jon Agley, Lilian Golzarri-Arroyo, Armando Peña, Danny Valdez, Abu Bakkar Siddique, Moonseong Heo, David B Allison

Children’s Nutrition Research Center Staff Publications

We conducted a critical review of the article “Effects on Children’s Physical and Mental Well-Being of a Physical-Activity-Based School Intervention Program: A Randomized Study”, published in the International Journal of Environmental Research and Public Health in 2023 as part of the Special Issue “Psychomotricity and Physical Education in School Health”. We identified multiple mistakes in the statistical analyses applied. First, the authors claim to have found a statistically significant association between the proposed intervention and change in body composition (body mass index (BMI) percentiles, relative fat mass, and BMI classes) by way of exhibiting differences in nominal significance between the …

How Societal Forces Of Change Are Transforming Youth Physical Activity Promotion In North America, Jacob Szeszulski, Jamie M Faro, Rodney P Joseph, Kevin Lanza, Lucie Lévesque, Courtney M Monroe, Elsa A Pérez-Paredes, Erica G Soltero, Rebecca E Lee

Children’s Nutrition Research Center Staff Publications

Background: Climate change, increasing recognition of institutionalized discrimination, and the COVID-19 pandemic are large-scale, societal events (ie, forces of change) that affect the timing, settings, and modes of youth physical activity. Despite the impact that forces of change have on youth physical activity and physical activity environments, few studies consider how they affect physical activity promotion.

Methods: The authors use 2 established frameworks, the ecological model of physical activity and the youth physical activity timing, how, and setting framework, to highlight changes in physical activity patterns of youth in North America that have resulted from contemporary forces of change.

Results: …

Feasibility Of A Food-Based Diabetes Self-Management Education Intervention For Food Insecure Patients With Type 2 Diabetes: A Convergent Mixed Methods Study, Eliza Short, Debbe Thompson, Douglas Taren, Holly Bryant, Rhonda Gonzalez, Jessi Sheava, Melanie Hingle

Children’s Nutrition Research Center Staff Publications

Objective: To assess the feasibility of a food-based diabetes self-management education and support (DSMES) intervention delivered to persons with type 2 diabetes (T2DM) and food insecurity.

Design: This single arm pre-/post convergent mixed methods study tested the feasibility of a 3-month intervention using food boxes, recipes, DSMES and dietitian visits. Feasibility benchmarks assessed were acceptability (> 50 % participants satisfied), demand (> 50 % used program components) and implementation (75 % adherence, 80 % retention). Assessments included: self-reported food security, health-related quality of life, diabetes self-efficacy, socio-demographic and dietary intake, height, weight, and HbA1c and one in-depth interview with participants …

The Effect Of Maternal Obesity On The Regulation Of Gene Expression And Cell Fate During Embryonic Cortical Neurogenesis, Thilina Thejinda Alawathugoda

Dissertations

Neurodevelopmental disorders have their roots in multifaceted origins that manifest during the earliest stages of embryonic growth, often linked to sophisticated gene regulation dynamics. A perturbed metabolic environment, specifically owing to maternal obesity, can lead to dyslipidemia, subsequently threatening the optimal development of the embryonic central nervous system. Growing evidence suggests that such metabolic irregularities during pregnancy can alter neurogenesis pathways, thus predisposing the developing fetus to neurodevelopmental disorders. One of the primary avenues through which these disruptions may occur is through alterations in histone modifications resulting from fluctuations in the expression of histone modifying enzymes or the availability of …

The Effect Of Parent-Child Relationships On Healthcare Utilization Among Children With Chronic Medical Health Concerns, Karina Guerra-Guzman

Theses and Dissertations

Parents of children with chronic health complaints are more likely to utilize healthcare services for their child, and are prone to experiencing increased stress and anxiety related to their child’s compromised health status. As these parents navigate managing their child’s health and integrating parenting behaviors, they are dealt with unique stressors that are likely to impact their parenting styles, anxiety, and use of healthcare services. However, most studies that have examined HCU in the context of parent-child relationships have neglected children with chronic health concerns (CHCs). This study examined the relationship between parenting styles across parents of children with a …

The Association Between Inflammatory Bowel Disease And All-Cause And Cause-Specific Mortality In The Uk Biobank, Fangyu Li, Yesenia Ramirez, Yukiko Yano, Carrie R Daniel, Shreela V Sharma, Eric L Brown, Ruosha Li, Baharak Moshiree, Erikka Loftfield, Qing Lan, Rashmi Sinha, Maki Inoue-Choi, Emily Vogtmann

Faculty, Staff and Student Publications

PURPOSE: Inflammatory bowel disease (IBD) has a rising global prevalence. However, the understanding of its impact on mortality remains inconsistent so we explored the association between IBD and all-cause and cause-specific mortality.

METHODS: This study included 502,369 participants from the UK Biobank, a large, population-based, prospective cohort study with mortality data through 2022. IBD was defined by baseline self-report or from primary care or hospital admission data. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality in multivariable Cox proportional hazards regression models.

RESULTS: A total of 5799 (1.2%) participants had a history of …

Shaping Policy And Practice: Analyzing The Reach Of Highly Cited And High Altmetrics Publications For Broader Impact On Physical Activity, Andrea Ramírez Varela, Natalicio Serrano, Juliana Mejía Grueso, Anita Nguyen, Deborah Salvo, Ross C Brownson, Adrian Bauman, Rodrigo Reis, Pedro Hallal, Michael Pratt

Faculty, Staff and Student Publications

BACKGROUND: A significant gap remains between the availability of physical activity (PA) evidence-based interventions and their application in real-world settings in policy and practice areas. This study aims to describe highly cited and high altmetrics publications in PA research and explore their impact on PA policy and practice.

METHODS: Mixed-methods sequential explanatory study including the identification and description of the top highly cited and high altmetrics PA publications from the last 10 years (including study design, population, type of PA study, number of citations, and altmetrics score), and interviews with key informants regarding research dissemination and implications on PA policy …

Identification And Delineation Of Neuronal Pathways Underlying Hypophagia, Jing Cai

Dissertations and Theses (Open Access)

In terms of metabolism, eating disorders manifest in two extreme directions: overnutrition, which can lead to obesity, and malnutrition, which can result in underweight or even starvation. Both extremes compromise the quality of life. According to the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) standard, eating disorders affect up to 17.9% of young women and 2.4% of young men. Although eating disorders are primarily defined as mental disorders rather than metabolic disorders, they are intertwined with complex emotions and sensory perceptions. However, in contemporary animal research related to eating disorders and feeding behaviors, the majority of neuroscientists still examine …

Synthesis Of Glucomannan-Xylan Composite Biofilms: Characterization And Applications For Food Packaging, Kholoud Al-Ajlouni

Dissertations

Scientists are most concerned about the need for green alternatives for efficient food packaging polymers to replace petroleum-based packaging products. The waste of corn cobs and the roots of the konjac plant contain hemicellulose, xylan and glucomannan respectively, and can be used to produce biofilms for food packaging.

The aim of these studies is to formulate biofilms from glucomannan-xylan blends that compete with petroleum-based plastic wrap. The biofilms must be strong, smooth, transparent, have a water vapor barrier, have the required mechanical properties and be cheap. Biofilms from glucomannan were stiff, lacked mechanical properties, and absorbed moisture. Therefore, it reacts …

Experimental And Computational Platforms For Studying Systems Mechanobiology, Brendyn Miller

All Dissertations

Mechanical stimulation through physical activity has been shown to play an important role in treating and preventing several non-communicable diseases such as hypertension, lower back pain (LBP), type-2 diabetes mellitus, and several cancers. This is accomplished through the regulation of cellular behavior and tissue remodeling within the body at both the micro- and macro-scale levels. The goal of mechanobiology research is to gain in-depth knowledge and understanding of how cells sense physical forces in conjunction with other biochemical cues and translate those factors into important biological functions that either maintain tissue homeostasis or lead to pathological states. Understanding these processes …

Economic Analysis Of Sod-Seeded Summer Annuals For Forage And Grazing, Ivanelle Meyer

Graduate Theses and Dissertations

Forage and pasture trials were conducted over the summers of 2021 and 2022 to assess how forage production and nutritive value of sorghum sudangrass, cowpea, and sorghum sudangrass-cowpea mixtures, sod-seeded to bermudagrass pasture would impact stocker cattle performance. The forage trials compared forage production and quality when poultry litter was surface or sub-surface applied biennially in comparison to a no poultry litter control. Poultry litter is a nutrient dense fertilizer utilized on pastures in the mid-southern United States to increase forage nutritive value and yield. Broadcasting poultry litter results in more nutrient losses due to runoff and nitrogen volatilization compared …

The Effect Of Financial Inclusion On Food Security: Evidence From Developing And Developed Countries, Yasmin Yasmin, Sekar Utami Setiastuti

Economics and Finance in Indonesia

This study investigates the global impact of financial inclusion on food security, with a focus on both developing and developed countries. The study constructs a financial inclusion index using the Sarma method and secondary data sourced from IMF and World Bank databases. System GMM is employed as the estimation method due to its effectiveness in addressing endogeneity issues and its efficient and consistent use of instruments. The analysis reveals that financial inclusion has a positive and statistically significant effect on food security across all research sub-samples. In addition, the study incorporates interaction variables between financial inclusion and the COVID-19 pandemic …

Investigating The Role Of Maternal Adiposity On Human Breast Milk And Preterm Infant Stool Short Chain Fatty Acid And Microbiome Profiles, Kristy L. Thomas

Electronic Theses and Dissertations

Preterm birth is the number one cause of death in neonates, accounting for 35% of neonatal mortality. The preterm birth rate in the U.S. in 2021 was 10.5%, disproportionally affected by race and ethnicity. Obese women have an increased risk of preterm pregnancy, and if delivered before 37 weeks of gestation, the offspring have higher rates of complications that extend from the neonatal period into life-long metabolic and immune adverse outcomes. In the early months after delivery, preterm infants have higher rates of adverse health outcomes than term infants, including infections, extrauterine growth restrictions, respiratory, metabolic, and neurological complications, necrotizing …

E-Cigarettes: What Is The Relationship Between E-Cigarette Usage And Periodontal Disease?, Deborah Rose

Electronic Theses and Dissertations

The dental community has a broad understanding of how traditional combustible cigarettes affect the oral cavity of the dental patient but there is little research available on the effects that e-cigarettes have on the patient’s dental health. Vaping products have been marketed as a healthier option over traditional combustible cigarettes. Since they were first introduced in 2003, very little research has been performed to understand their dental implications. This project was executed to investigate the chemicals associated with these vaping products and how they possibly contribute to the progression of periodontal disease. This research project was conducted with the contribution …

Unlocking The Mysteries Of Opportunism: Neuroendocrine Insights From An Aseasonal Breeder (Taeniopygia Guttata), Jessica A. Moodie

Graduate Theses and Dissertations (2019 - present)

The regulation of reproductive physiology in animals is mediated by the Hypothalamus-Pituitary-Gonad (HPG) axis. In seasonal breeders, a conserved reciprocal switching of deiodinase enzymes alters thyroid hormone signaling, which controls HPG activity. This study tested the hypothesis that neural regulation of the HPG axis as described in seasonal systems is conserved and repurposed to respond to other cues in aseasonal species. Using water deprivation and nest restriction in the opportunistic Zebra Finch, we were able to create a breeding group and non-breeding group, confirmed by egg laying and changes in ovarian anatomy. Breeding females had clear follicular hierarchy, increased ovary …

Who Owns Children’S Dna?, Nila Bala

Michigan Law Review

In recent years, DNA has become increasingly easy to collect, test, and sequence, making it far more accessible to law enforcement. While legal scholars have examined this phenomenon generally, this Article examines the control and use of children’s DNA, asking who ultimately owns children’s DNA. I explore two common ways parents—currently considered “owners” of children’s DNA— might turn over children’s DNA to law enforcement: (1) “consensual” searches and (2) direct-to-consumer testing. My fundamental thesis is that parental consent is an insufficient safeguard to protect a child’s DNA from law enforcement. At present, the law leaves parents in complete control of …

Biological Age Mediates The Effects Of Perceived Neighborhood Problems On Heart Failure Risk Among Black Persons, Ganga Bey, James Pike, Priya Palta, Anthony Zannas, Qian Xiao, Shelly-Ann Love, Gerardo Heiss

Faculty, Staff and Student Publications

OBJECTIVE: We assessed whether biological age, measured by the epigenetic clock GrimAge, mediates the association of objective and subjective neighborhood disadvantage with incident HF among Black persons.

METHODS: Participants were 1448 self-reported Black adults (mean age (standard deviation, SD) = 64.3 (5.5)) dually enrolled in two community-based cohorts in Jackson, Mississippi, the ARIC and JHS cohorts, who were free of HF as of January 1, 2000. Incident HF events leading to hospitalization through December 31, 2017, were classified using ICD-9 discharge codes of HF. Multilevel age- and sex-adjusted Cox causal mediation models were used to examine whether biological age (at …

Alignment Between 24-H Light-Dark And Activity-Rest Rhythms Is Associated With Diabetes And Glucose Metabolism In A Nationally Representative Sample Of American Adults, Qian Xiao, John Durbin, Cici Bauer, Chris Ho Ching Yeung, Mariana G Figueiro

Faculty, Staff and Student Publications

OBJECTIVE: The alignment between environmental stimuli (e.g., dark, light) and behavior cycles (e.g., rest, activity) is an essential feature of the circadian timing system, a key contributor to metabolic health. However, no previous studies have investigated light-activity alignment in relation to glycemic control in human populations.

RESEARCH DESIGN AND METHODS: The analysis included ∼7,000 adults (aged 20-80 years) from the National Health and Nutrition Examination Survey (NHANES) (2011-2014) with actigraphy-measured, multiday, 24-h activity and light data. We used phasor analysis to derive phasor magnitude and phasor angle, which measures coupling strength and phase difference between the activity-rest and light-dark cycles, …

Diet Induced Metabolic Alterations In The Brain Tissues Of Juvenile Pigs With Non-Alcoholic Fatty Liver Disease, Rhesa Lacanienta

Master's Theses

The objective of this study was to investigate the diet-induced metabolic changes that affect the brain tissue of juvenile pigs with NAFLD. This study explored the liver- brain axis and metabolic markers in the frontal cortex (FC) affected by liver damage. 18 male (M) and 20 female (F) Iberian pigs were randomly allocated to 1 of 3 high-fructose high-fat liquid diets (lard, olive oil, and coconut oil) and fed for 10 consecutive weeks. “Healthy” Iberian pigs were fed a eucaloric diet to establish a physiological baseline. Protein precipitation extraction using ultra-performance liquid chromatography-tandem quadrupole mass spectrometry was performed for primary …

The Family Strength Wheel: A Strength-Based Visual Tool For Families, Genese Clark

Journal of Extension

In 2017, data was collected from 59 African-Americans living in the northeastern United States to investigate the saliency of six family strength domains. The study results highlighted an emerging domain, Leadership, and led to the development of a visual family strength tool adapted from DeFrain's (2002) American Family Strength Inventory for family practitioners. With a supplemental worksheet, the Family Strength Wheel provides a self-rating scale illustrating baselines for strength-based family functioning while simultaneously showing benchmarks for improvement. The Family Strength Wheel offers immediate insight into individuals' perceptions of their family's functioning, opening areas for dialogue between family members and practitioners.

Evaluating Physical Activity Resources To Support Health Equity In Arizona, Kathryn M. Orzech, Theresa A. Legros, Laurel Jacobs, Gregory Goodman, Ryan Lang

Journal of Extension

We evaluated physical activity (PA) resources in lower-income Arizona communities to support the Supplemental Nutrition Assistance Program – Education (SNAP-Ed) in pursuing equitable policy, systems, and environment (PSE) interventions. In 2017, 71 PA resources across 10 counties (65% parks) were rated using the Physical Activity Resource Assessment (PARA) tool. Accessibility was high, but condition scores and attractiveness varied across resources, with no rural/urban differences. Results suggest that Extension SNAP-Ed staff can be agents of change by assessing resource condition where physical activity health inequities may exist and then convening partners to begin to address needed changes.

Resiliency In Families Of Children With Low Vision, Deborah Lynn Mendoza

Dissertations

Resiliency is comprised of a complex interplay of risk and protective factors that change and develop over time. In the past, research focused on characteristics that allowed individuals to remain untouched by negative events around them; however, over time, this has morphed into investigating not only the characteristics individuals possess but those present within families as well. Families of children who have either a congenital or an acquired disability could face a unique set of risk factors over time that might require different protective factors to ensure they emerged from their adversity positively changed. As professionals, we have a responsibility …

Barriers And Facilitators To Enrollment For Free And Reduced Price Meals In The School Nutrition Program Among Lawrence Public School Families, Emily Brinkman

Capstone Experience: Master of Public Health

Many low-income families are facing nutrition insecurity, meaning they do not have consistent and equitable access to healthy, safe, affordable foods to meet needs for optimal health and well-being. The impact of nutrition insecurity is especially concerning for children as they are more likely to face adverse outcomes that can limit physical, intellectual, and emotional potential across the lifespan. The U.S. Department of Agriculture administers the School Nutrition Programs that can help improve access to nutritious foods. Eligible families can apply for their children to receive free or reduced-price school meals based on income level and household size. However, many …