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Articles 28951 - 28980 of 240168
Full-Text Articles in Entire DC Network
Pengaruh Kesehatan Mental Ibu Terhadap Status Gizi Anak Di Indonesia, Yuyu Pertiwi, Elda L. Pardede
Pengaruh Kesehatan Mental Ibu Terhadap Status Gizi Anak Di Indonesia, Yuyu Pertiwi, Elda L. Pardede
Jurnal Ekonomi Kependudukan dan Keluarga
Malnutrition in children is still a problem in low and middle-income countries, including Indonesia. This research aims to assess how the mother's mental health influences the child's nutritional status, measured by stunting and underweight status, in the short term (when the child is 0-5 years old) and long-term (when the child is 7-12 years old). Using the Indonesia Family Life Survey 2007 and 2014 data, the logistic regression results shows that children of mothers with mental health problem have a greater tendency to experience underweight nutritional status in both the short and long term. However, the influence of maternal mental …
Teaching Critical Media Literacy In An Advanced-Level Classroom Through The Eyes Of Journalism As A Profession, Alexandra Shapiro
Teaching Critical Media Literacy In An Advanced-Level Classroom Through The Eyes Of Journalism As A Profession, Alexandra Shapiro
Russian Language Journal
This paper presents an approach to promoting social media literacy in a Russian language class. The instruction was conducted within a university setting for Flagship students in their third year of Russian studies. The course focused on teaching professional Russian to students at the Intermediate Mid to Advanced levels. It is modular and covers several topics, including journalism, law, and human rights, among others. The overall aim of the course was to help students develop critical thinking skills, expose them to Russian language and culture, and enable them to stay informed about current events while discussing a wide range of …
The Importance Of Multidisciplinary Approach In Management Of Pressure Injury In Elderly With Multiple Comorbidities, Dina Kusumawardhani, Shannaz Nadia Yusharyahya, Lili Legiawati, Rinadewi Astriningrum, Kara Adistri
The Importance Of Multidisciplinary Approach In Management Of Pressure Injury In Elderly With Multiple Comorbidities, Dina Kusumawardhani, Shannaz Nadia Yusharyahya, Lili Legiawati, Rinadewi Astriningrum, Kara Adistri
Journal of General - Procedural Dermatology and Venereology Indonesia
Background: Pressure injury (PI) can occur as a result of prolonged bed rest in immobilized patients. The healing process is often slow if the wounds are not managed comprehensively, particularly in elderly patients or patients with neurological disorder, diabetes mellitus, and malnutrition. Proper treatment can improve the healing process.
Case illustration: A 66-year-old female with multiple comorbidities presented with PI on the left lower back, as well as the sacral and right gluteal regions. She was diagnosed with grade 3 and unstageable PI, and was treated using a multidisciplinary approach. Her wounds were treated with a combination of …
The Use Of Ultraviolet Radiation As A Means Of Destroying Microorganisms In Cherries, Jasur Safarov, Shaxnoza Sultanova, Pulatov M. Murodjon
The Use Of Ultraviolet Radiation As A Means Of Destroying Microorganisms In Cherries, Jasur Safarov, Shaxnoza Sultanova, Pulatov M. Murodjon
Chemical Technology, Control and Management
The article discusses methods for extending the shelf life of cherries, having previously treated it with an ultraviolet ray. The article also presents the results obtained, which prove that the shelf life of cherries exposed to ultraviolet increases. At the same time, the article describes in detail the processing technique and presents the results of research.
Identifying The Need, Metrics, And Themes For Future Development Of A Fluid Balance Assessment Tool In End Stage Kidney Disease (Eskd): A Dietitian’S Perspective, Susan Laycock
South West Clinical School Journal
#400WORDS: CHIEF NURSING OFFICER’S RESEARCH FELLOWS EVIDENCE IMPLEMENTATION PROJECTS
Exploring Basic Science Knowledge Retention Within A Cohort Of Undergraduate Medical Students In The United Kingdom: A Longitudinal Study, Idrees Zafar, John Chilton, James Edwards, Helen Watson, Daniel Zahra
Exploring Basic Science Knowledge Retention Within A Cohort Of Undergraduate Medical Students In The United Kingdom: A Longitudinal Study, Idrees Zafar, John Chilton, James Edwards, Helen Watson, Daniel Zahra
Peninsula Medical School
Background Clinical reasoning is reliant on students having acquired a strong foundation in the basic sciences. However, there remains uncertainty regarding whether medical students are maintaining this knowledge over the span of their degrees. Therefore, this project aimed to assess long-term retention of basic science knowledge within a cohort of students from an undergraduate medical school in the United Kingdom (UK). Methods This longitudinal study followed a cohort of students, from their first to final year. In their final year, participants sat a bespoke formative basic science knowledge assessment that utilised 46 single-best-answer questions. To examine for long-term attainment differences, …
Situation Analysis Of Health Problems In Depok City In 2021, Murti Utami Putri, Asri C. Adisasmita, Hidayat Nuh Ghazali Djajuli
Situation Analysis Of Health Problems In Depok City In 2021, Murti Utami Putri, Asri C. Adisasmita, Hidayat Nuh Ghazali Djajuli
Jurnal Epidemiologi Kesehatan Indonesia
Based on 2021 data, from the results of problem identification, 16 health problems in Depok City were assessed. Maternal mortality was selected as a priority problem with 65 cases of maternal death or 155.58 per 100,000 live births. COVID-19 infection is the most common cause of maternal death. This study aims to provide an overview of maternal death circumstances in Depok because of prioritization following situation analysis of health problems. This situation analysis was conducted in Depok with a quantitative and qualitative approach analyzed using the PAHO-adapted Hanlon involving the participation of 17 respondents from the Health Office and the …
Pemetaan Stunting, Wasting, Dan Obesitas Berdasarkan Kondisi Geografis Di Kota Palembang, Athiyah Ashilah, Najmah Najmah, Feri Fahrizal, Trisnawarman Trisnawarman, Sri Rahayu, Rahma Zahara
Pemetaan Stunting, Wasting, Dan Obesitas Berdasarkan Kondisi Geografis Di Kota Palembang, Athiyah Ashilah, Najmah Najmah, Feri Fahrizal, Trisnawarman Trisnawarman, Sri Rahayu, Rahma Zahara
Jurnal Epidemiologi Kesehatan Indonesia
Saat ini Indonesia mengalami masalah “triple burden”, yaitu tingginya kasus stunting dan wasting serta masalah gizi berupa obesitas dan kekurangan zat gizi mikro. Prevalensi stunting di Kota Palembang berada pada angka 14,3%, wasting 7,8%, dan obesitas 5,6%. Secara tidak langsung, kondisi geografis merupakan salah satu faktor yang mempengaruhi status gizi. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pemetaan kejadian stunting, wasting, dan obesitas di Kota Palembang berdasarkan kondisi geografisnya. Penelitian ini merupakan penelitian kuantitatif dengan desain studi ekologi deskriptif menggunakan data sekunder yang kemudian dianalisis dengan software QGIS. Populasi pada penelitian ini adalah seluruh balita yang ada di Kota …
On The Discontinuation Of Enteral Feeding In Head And Neck Cancer: A Case Report, Kyle Fisk, Ana Sanchez
On The Discontinuation Of Enteral Feeding In Head And Neck Cancer: A Case Report, Kyle Fisk, Ana Sanchez
HCA Healthcare Journal of Medicine
Introduction
The goal of palliative care is to preserve the quality of life or patient “comfort” in patients with serious diseases. Palliative care providers serve a wide range of patients: from those who seek curative treatment to those who are actively dying. Given this range, palliative care must mirror the dynamic goals of the patient at different stages of life and treatment. Throughout these stages, a goal of the palliative care provider would be to avoid hastening death; however, this often leads to clinical decisions that directly pit the patient’s comfort against the patient’s life span. This is most salient …
A Rare Case Of Candida Glabrata Cervical Spondylodiscitis, Angelina Hong, Lily Hyungjung Lim, Ali Tariq Alvi, Pallavi Aneja
A Rare Case Of Candida Glabrata Cervical Spondylodiscitis, Angelina Hong, Lily Hyungjung Lim, Ali Tariq Alvi, Pallavi Aneja
HCA Healthcare Journal of Medicine
Introduction
Invasive candidiasis can lead to numerous life-threatening sequelae. Candida glabrata is the second-most common causative species of invasive candidiasis. This species possesses a high risk for persistent infection and candidemia. An uncommon complication of invasive candidiasis is spondylodiscitis and can rarely affect the cervical spine.
Case Presentation
The patient is a female in her late 50s with a complex medical history inclusive of chronic obstructive pulmonary disease, chronic pain, multiple abdominal surgeries, prolonged intensive care unit admission, and administration of total parenteral nutrition and broad-spectrum antibiotics who presented with complaints of worsening neck pain. She was last hospitalized 3 …
Effects Of Attending To A 12-Week Structured Physical Activity Program On Fitness And Self-Perception Levels Of Obese Primary Schoolchildren, Yetkin Utku Kamuk, Spiridon Kamtsios
Effects Of Attending To A 12-Week Structured Physical Activity Program On Fitness And Self-Perception Levels Of Obese Primary Schoolchildren, Yetkin Utku Kamuk, Spiridon Kamtsios
Baltic Journal of Health and Physical Activity
Introduction: Childhood obesity is a major health problem especially for schoolchildren both physically and mentally. The study was conducted to assess the effects of the structured physical activity (PA) program on the physical fitness (PF) and self-perception levels of obese schoolchildren. Materials and Methods: A total of 67 students aged 9-11 were recruited and the experimental group (n = 27) was attended to exercises once per week for 60 mins for 12 weeks. Self-perception Scale for Children and PF tests were applied as pre- and post-tests. Results: 12-week PA sessions improved obese schoolchildren’s self-perception levels in general self-worth, athletic …
Utilizing An Extract From Endophytic Fungus, Alternaria Alternata, Isolated From Ricinus Communis L. Leaves As A Biological Agent For Controlling The Migratory Locust In Algeria, Laib Djamel Eddine, Benzehra Abdelmadjid, Laib Imen, Aouzal Badis, Akkal Salah
Utilizing An Extract From Endophytic Fungus, Alternaria Alternata, Isolated From Ricinus Communis L. Leaves As A Biological Agent For Controlling The Migratory Locust In Algeria, Laib Djamel Eddine, Benzehra Abdelmadjid, Laib Imen, Aouzal Badis, Akkal Salah
Journal of Bioresource Management
In this research, we aimed to explore the insecticidal potential of Alternaria alternata, an endophytic fungus derived from the leaves of castor oil plant. To test its insecticidal efficacy, various doses of A. alternata mycoextract were administered to Locusta migratoria L. through both topical and oral pathways. The findings revealed that the insects displayed the highest susceptibility to a concentration of 2 g/L, leading to an impressive mortality rate of 87.5 % and 93.75 % for topical and oral administrations, in the same order. The extract displayed remarkable insecticidal properties, demonstrating LC50 values of 1.09 g/L for the topical …
Promoting Health Improvement Of Indonesian Migrant Workers And Their Children In Kuala Lumpur, Malaysia, Mitoriana Porusia, Listiana Masyita Dewi, Dewi Pertiwi Dyah Kusudaryati, Yuli Widyastuti, Lia Kicky Mahmudi, Wulan Prasesti, Fahwa Nyssa Insyiroh, Niken Diah Haryanti, Muhammad Fathan Nuralam, Nastiti Farasvita Putri, Miranda Azahra, Rafif Ryandra Izdhihar, Zulia Setiyaningrum, Siti Sabariah Buhari
Promoting Health Improvement Of Indonesian Migrant Workers And Their Children In Kuala Lumpur, Malaysia, Mitoriana Porusia, Listiana Masyita Dewi, Dewi Pertiwi Dyah Kusudaryati, Yuli Widyastuti, Lia Kicky Mahmudi, Wulan Prasesti, Fahwa Nyssa Insyiroh, Niken Diah Haryanti, Muhammad Fathan Nuralam, Nastiti Farasvita Putri, Miranda Azahra, Rafif Ryandra Izdhihar, Zulia Setiyaningrum, Siti Sabariah Buhari
ASEAN Journal of Community Engagement
This article discusses the health promotion program among Indonesian migrant workers and their children living in Kuala Lumpur, Malaysia, aiming for a better awareness of their health condition. In particular, this article describes and analyzes the community engagement program in Sekolah Indonesia Kuala Lumpur (SIKL) and Muhammadiyah Malaysia (PCIM) to provide health education and screening. Based on the preliminary study, Indonesian migrant workers and their families have limited access to healthcare facilities and programs. The program covers topics such as healthy reproduction and sexual vigilance for the youth, well-being and healthy lifestyles, as well as the importance
of basic health …
Food Additive Evidence In Food Supplements Most Commonly Consumed By Cancer Patients, Safa Mazouzi, Samira Djekoun Bensoltane, Sabiha Bouzbid, Nesrine Adjabi
Food Additive Evidence In Food Supplements Most Commonly Consumed By Cancer Patients, Safa Mazouzi, Samira Djekoun Bensoltane, Sabiha Bouzbid, Nesrine Adjabi
Journal of Bioresource Management
The goal of this research is to highlight food additives in the formulations of food supplements consumed by cancer patients. It is a survey conducted at the Cancer treatment center in Annaba to collect a list of food supplements used by these patients. Following a screening of their ingredients for incorporated food additives, which we then classified according to the degree of toxicity, these supplements were classified according to their origin (local or imported). Our findings show that these various groups of dietary supplements contain a variety of food additives with varying degrees of toxicity, such as colorants (E422), acidity …
Women, Food, And Diet In The Middle Ages: Balancing The Humors, Autumn Reinhardt-Simpson
Women, Food, And Diet In The Middle Ages: Balancing The Humors, Autumn Reinhardt-Simpson
Medieval Feminist Forum: A Journal of Gender and Sexuality
No abstract provided.
Extraction/Transportation Of Co2+ Metal Ions With Bis(2-Ethylhexyl) Phosphate Dissolved In Kerosene Using A Multidropped Liquid Membrane Technique, Volkan Demi̇rel, Ramazan Donat
Extraction/Transportation Of Co2+ Metal Ions With Bis(2-Ethylhexyl) Phosphate Dissolved In Kerosene Using A Multidropped Liquid Membrane Technique, Volkan Demi̇rel, Ramazan Donat
Turkish Journal of Chemistry
The transport properties of Co2+ ions from the aqueous donor phase to aqueous acceptor phase with the recently developed multidroplet liquid membrane (MDLM) extraction system were studied. This system serves as a continuous process for the transportation of ions and requires fewer reagents for starting and conducting the procedure. Moreover, the procedure results in fewer waste chemicals and mixtures in comparison to traditional extraction methods. During extraction, bis(2-ethylhexyl) phosphate (D2EHPA) was used as a carrier material and 5% potassium thiocyanate (KSCN) solution was used to obtain a colored complex for UV-Vis detection. By means of several experiments, the optimum D2EHPA …
Ph Responsive Curcumin Released From Urea-Amine Group Functionalized Mesoporous Organosilica Nanoparticles, Osman Tayyar Arli, Yaşar Gök, Hali̇l Zeki̇ Gök
Ph Responsive Curcumin Released From Urea-Amine Group Functionalized Mesoporous Organosilica Nanoparticles, Osman Tayyar Arli, Yaşar Gök, Hali̇l Zeki̇ Gök
Turkish Journal of Chemistry
Studies on natural products with anticancer properties have gained more importance in recent years in order to not damage healthy tissues during cancer treatments or to perform the treatment causing the least damage. Curcumin is a common natural product with anticancer properties, but its low solubility, instability, and bioavailability have limited its use in clinical applications in cancer research. As a proposed solution to this problem, a new mesoporous organosilica nanocarrier (MON-A) functionalized with a 1,2-diphenylethane-1,2-diamine structure capable of pH-controlled release was prepared in this study. MON-A was characterized by TGA, BET, XRD, FT-IR, and SEM-EDS analyses. Dispersion of MON-A …
Participant Engagement In A Community Health Worker-Delivered Intervention And Type 2 Diabetes Clinical Outcomes: A Quasiexperimental Study In Mexicanamericans, Belinda M. Reininger, Juliana Z. Lopez, Maria E. Zolezzi, Minjae Lee, Lisa A. Mitchell-Bennett, Tianlin Xu, Soo Kyung Park, Mayra V. Saldana, Lubeth Perez, Joseph B. Mccormick
Participant Engagement In A Community Health Worker-Delivered Intervention And Type 2 Diabetes Clinical Outcomes: A Quasiexperimental Study In Mexicanamericans, Belinda M. Reininger, Juliana Z. Lopez, Maria E. Zolezzi, Minjae Lee, Lisa A. Mitchell-Bennett, Tianlin Xu, Soo Kyung Park, Mayra V. Saldana, Lubeth Perez, Joseph B. Mccormick
Health & Biomedical Sciences Faculty Publications
Objectives This study helps to fill the existing research gap related to participant engagement in behavioural interventions and diabetes management. We examined type 2 diabetes control over time among Mexican Americans by level of engagement in a chronic care management (CCM) program that included community health worker (CHW)-delivered multilevel interventions. The programme complemented clinical care and promoted behaviour changes to improve diabetes self-management.
Design Quasiexperimental study.
Setting The study was implemented in the Rio Grande Valley region in the USA. Recruitment was conducted in clinics and community events. All other visits were provided in participant homes and community locations.
Participants …
Faux Feminism In A Capitalistic Fever Dream: A Review Of Greta Gerwig's Barbie (2023), Amy La Porte, Lena Cavusoglu
Faux Feminism In A Capitalistic Fever Dream: A Review Of Greta Gerwig's Barbie (2023), Amy La Porte, Lena Cavusoglu
Markets, Globalization & Development Review
Somewhere between meaningful discourse about female agency and the commercial interests of a problematic doll franchise lies Mattel's box office hit film Barbie, directed by Greta Gerwig. In a script-flipping interpretation of the real-world patriarchy, it catapults itself into overdue discussions about gender norms, objectification, and the pursuit of Westernized beauty ideals. While it may have introduced liberationist theories to a new generation of women, ultimately it is a film bound by cognitive dissonance. This paper will delve into the profit-making protagonist at the center of its story and argue the film's underlying incompatibility with diversity, feminism, and social …
“What Should I Do About This New Left Bundle Branch Block?”, Muhammad Asad Hanif, Muhammad Mohsin Zafar, Aniruddha Singh
“What Should I Do About This New Left Bundle Branch Block?”, Muhammad Asad Hanif, Muhammad Mohsin Zafar, Aniruddha Singh
Transformative Medicine
No abstract provided.
Microgreens Nutrition Outreach: A Novel Tool For Community-Wide Dietary Disease Prevention, Rayna Marshall, Jessica Nwabeke, Benjamin S. Haslund-Gourley, Cynthia Huang, Talmadge Gaither, Vibhuti Mishra, Sophia Kim, Hannah Xu, Faith Kean, Neiki Rokni, Annette Gadegbeku
Microgreens Nutrition Outreach: A Novel Tool For Community-Wide Dietary Disease Prevention, Rayna Marshall, Jessica Nwabeke, Benjamin S. Haslund-Gourley, Cynthia Huang, Talmadge Gaither, Vibhuti Mishra, Sophia Kim, Hannah Xu, Faith Kean, Neiki Rokni, Annette Gadegbeku
Transformative Medicine
Purpose: To investigate how microgreens educational programming impacts the relationship between nutrition attitudes and healthy eating habits. Methods: A three-part workshop in Philadelphia, PA that consisted of a pre-survey, presentation, and microgreens kit assembly session was held. A post-survey was distributed electronically 1 week after the event. Results: 9 participants voluntarily attended the workshop and completed the pre-survey, and one-third of the participants submitted post-survey feedback. Participants were middle-aged, Black women from the Allegheny West neighborhood of Philadelphia, a predominantly (97.5%) Black neighborhood. The survey showed microgreens were well-received and suited for urban communities with little space and cold weather. …
The Crimson (Dec.), Yannick L. Brookes
The Crimson (Dec.), Yannick L. Brookes
Office of Student Affairs
Student newsletter - End of Semester Edition
Preoperative Neutrophil–Lymphocyte Ratio And Serum Carcinoembryonic Antigen As Predictive Factors Of Colorectal Cancer Survival, Agi S. Putranto, Jackson Kamaruddin
Preoperative Neutrophil–Lymphocyte Ratio And Serum Carcinoembryonic Antigen As Predictive Factors Of Colorectal Cancer Survival, Agi S. Putranto, Jackson Kamaruddin
The New Ropanasuri Journal of Surgery
Introduction. Colorectal cancer is the second leading cause of death worldwide, with a high mortality rate. This study investigates the predictive value of the neutrophil–lymphocyte ratio (NLR) and carcinoembryonic antigen (CEA) in predicting the survival rates of colorectal cancer patients in Indonesia.
Method. This retrospective cohort study enrolled the colorectal cancer stage I–IV patients treated at Cipto Mangunkusumo General Hospital (CMGH). The independent variables are NLR and CEA, while the dependent variable is the five–year survival of colorectal cancer. The log rank test proceeded to find a correlation between NLR and CEA with 5–year survival, and the Cox proportional hazard …
Factors Influencing Ulcer Healing In Chronic Limb Threatening Ischemia Patients After Endovascular Angioplasty At Cipto Mangunkusumo General Hospital, Raden Suhartono, Ghany H. Wijaya, Akhmadu Muradi
Factors Influencing Ulcer Healing In Chronic Limb Threatening Ischemia Patients After Endovascular Angioplasty At Cipto Mangunkusumo General Hospital, Raden Suhartono, Ghany H. Wijaya, Akhmadu Muradi
The New Ropanasuri Journal of Surgery
Introduction. Chronic limb–threatening ischemia (CLTI) can cause rest pain in the lower extremities and the formation of ulcers or gangrene. Revascularization, which can be done using open surgery or endovascular procedures, is the first line of treatment in CLTI management. CLTI patients at CMGH usually came with advanced conditions and high re–amputation rates even after revascularization. This study aimed to determine factors associated with the outcome of endovascular angioplasty, especially ulcer healing.
Method. A cross–sectional study was conducted at CMGH, enrolling CLTI patients with Rutherford grades 5 and 6 who underwent angioplasty. Age, gender, history of smoking, hypertension, atrial fibrillation, …
Genital Tract Infections, The Vaginal Microbiome And Gestational Age At Birth Among Pregnant Women In South Africa: A Cohort Study Protocol, Ranjana M.S. Gigi, Mandisa M. Mdingi, Hyunsul Jung, Shantelle Claassen-Weitz, Lukas Bütikofer, Jeffrey D. Klausner, Christina A. Muzny, Christopher M. Taylor, Janneke H.H.M. Van De Wijgert, Remco P.H. Peters, Nicola Low
Genital Tract Infections, The Vaginal Microbiome And Gestational Age At Birth Among Pregnant Women In South Africa: A Cohort Study Protocol, Ranjana M.S. Gigi, Mandisa M. Mdingi, Hyunsul Jung, Shantelle Claassen-Weitz, Lukas Bütikofer, Jeffrey D. Klausner, Christina A. Muzny, Christopher M. Taylor, Janneke H.H.M. Van De Wijgert, Remco P.H. Peters, Nicola Low
School of Medicine Faculty Publications
Introduction Preterm birth complications are the most common cause of death in children under 5 years. The presence of multiple microorganisms and genital tract inflammation could be the common mechanism driving early onset of labour. South Africa has high levels of preterm birth, genital tract infections and HIV infection among pregnant women. We plan to investigate associations between the presence of multiple lower genital tract microorganisms in pregnancy and gestational age at birth. Methods and analysis This cohort study enrols around 600 pregnant women at one public healthcare facility in East London, South Africa. Eligible women are ≥18 years and …
Amondys 45 (Casimersen), A Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations For Treatment In Duchenne Muscular Dystrophy, Megan E. Vasterling, Rebecca J. Maitski, Brice A. Davis, Julie E. Barnes, Rucha A. Kelkar, Rachel J. Klapper, Hirni Patel, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye, Giustino Varrassi
Amondys 45 (Casimersen), A Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations For Treatment In Duchenne Muscular Dystrophy, Megan E. Vasterling, Rebecca J. Maitski, Brice A. Davis, Julie E. Barnes, Rucha A. Kelkar, Rachel J. Klapper, Hirni Patel, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye, Giustino Varrassi
School of Medicine Faculty Publications
AMONDYS 45 (casimersen) is an antisense oligonucleotide therapy used to treat Duchenne muscular dystrophy (DMD), a rare genetic disorder characterized by a mutation in the DMD gene. Symptoms include progressive muscle weakness, respiratory and cardiac complications, and premature death. Casimersen targets a specific mutation in the DMD gene that results in the absence of dystrophin protein, a key structural component of muscle fibers. While there is currently no cure for DMD, exon-skipping therapy works by restoring the reading frame of the mutated gene, allowing the production of a partially functional dystrophin protein. Clinical trials of casimersen have shown promising results …
Maternal Western Diet Programs Cardiometabolic Dysfunction And Hypothalamic Inflammation Via Epigenetic Mechanisms Predominantly In The Male Offspring, Mona Elgazzaz, Clara Berdasco, Jone Garai, Melody Baddoo, Shiping Lu, Hisham Daoud, Jovanny Zabaleta, Franck Mauvais-Jarvis, Eric Lazartigues
Maternal Western Diet Programs Cardiometabolic Dysfunction And Hypothalamic Inflammation Via Epigenetic Mechanisms Predominantly In The Male Offspring, Mona Elgazzaz, Clara Berdasco, Jone Garai, Melody Baddoo, Shiping Lu, Hisham Daoud, Jovanny Zabaleta, Franck Mauvais-Jarvis, Eric Lazartigues
School of Medicine Faculty Publications
Objective; Maternal exposure during pregnancy is a strong determinant of offspring health outcomes. Such exposure induces changes in the offspring epigenome resulting in gene expression and functional changes. In this study, we investigated the effect of maternal Western hypercaloric diet (HCD) programming during the perinatal period on neuronal plasticity and cardiometabolic health in adult offspring. Methods; C57BL/6J dams were fed HCD for 1 month prior to mating with regular diet (RD) sires and kept on the same diet throughout pregnancy and lactation. At weaning, offspring were maintained on either HCD or RD for 3 months resulting in 4 treatment groups …
Glp1 Receptor Agonists-Effects Beyond Obesity And Diabetes, Sydney S Wilbon, Mikhail G Kolonin
Glp1 Receptor Agonists-Effects Beyond Obesity And Diabetes, Sydney S Wilbon, Mikhail G Kolonin
Faculty, Staff and Student Publications
Glucagon-like peptide-1 receptor agonists (GLP1RA) have been transformative for patients and clinicians in treating type-2 diabetes and obesity. Drugs of this class, the bioavailability of which is continuously improving, enable weight loss and control blood glucose with minimal unwanted side effects. Since adopting GLP1RA for treating metabolic diseases, animal and clinical studies have revealed their beneficial effects on several other pathologies, including cardiovascular diseases, neurodegeneration, kidney disease, and cancer. A notable commonality between these diseases is their association with older age. Clinical trials and preclinical data suggest that GLP1RA may improve outcomes in these aging-related diseases. Some of the benefits …
Social Determinants Of Health And Disparities In Hypertension And Cardiovascular Diseases, Abhishek Chaturvedi, Anqi Zhu, Naga Vaishnav Gadela, Dorairaj Prabhakaran, Tazeen Jafar
Social Determinants Of Health And Disparities In Hypertension And Cardiovascular Diseases, Abhishek Chaturvedi, Anqi Zhu, Naga Vaishnav Gadela, Dorairaj Prabhakaran, Tazeen Jafar
Department of Medicine
High blood pressure causes over 10 million preventable deaths annually globally. Populations in low- and middle-income countries suffer the most, experiencing increased uncontrolled blood pressure and cardiovascular disease (CVD) deaths. Despite improvements in high-income countries, disparities persist, notably in the United States, where Black individuals face up to 4× higher CVD mortality than White individuals. Social determinants of health encompass complex, multidimensional factors linked to an individual's birthplace, upbringing, activities, residence, workplaces, socioeconomic and environmental structures, and significantly affect health outcomes, including hypertension and CVD. This review explored how social determinants of health drive disparities in hypertension and related CVD …
Blue Economic Potency Of Marine Invertebrates For Bio-Drug Discovery, Hassan A.H. Ibrahim, Hanan M. Abdelnaby, Samia S. Abouelkheir, Hamdy A. Abo-Taleb, Nermeen A. El Sersy
Blue Economic Potency Of Marine Invertebrates For Bio-Drug Discovery, Hassan A.H. Ibrahim, Hanan M. Abdelnaby, Samia S. Abouelkheir, Hamdy A. Abo-Taleb, Nermeen A. El Sersy
Blue Economy
In terms of focus, promising results obtained from extensive investigations showed that the biodiversity of marine invertebrates has been documented. This poses the marine ecosystem as a hopeful resource in the discovery of novel compounds, with an ideal starting point in scaffolding additional screening of marine natural products (MNPs), especially to face the rise in the burden of diseases and treatment failure. A wide range of antimicrobial, antiviral, anticancer, anti-inflammatory, antiparasitic, neuroprotective, analgesic, antimalarial and other agents of marine origin have been pursued in the control and management of diseases. In the current review, we will focus on figuring out …