Digital Commons Network^™

2024 Belknap County 4-H Presents, Karen Deighan

UNH Cooperative Extension

No abstract provided.

2023 Health & Well-Being Team Highlights, Amy Hollar, Kendra Lewis, Michael C. Young

UNH Cooperative Extension

No abstract provided.

North Haverhill Fair 4-H Exhibit Hall Information Packet - 2024, Extension

UNH Cooperative Extension

No abstract provided.

Posttransplantation Late Complications Increase Over Time For Patients With Scid: A Primary Immune Deficiency Treatment Consortium (Pidtc) Landmark Study, Hesham Eissa, Monica S Thakar, Ami J Shah, Brent R Logan, Linda M Griffith, Huaying Dong, Roberta E Parrott, Richard J O'Reilly, Jasmeen Dara, Neena Kapoor, Lisa Forbes Satter, Sharat Chandra, Malika Kapadia, Shanmuganathan Chandrakasan, Alan Knutsen, Soma C Jyonouchi, Lyndsay Molinari, Ahmad Rayes, Christen L Ebens, Pierre Teira, Blachy J Dávila Saldaña, Lauri M Burroughs, Sonali Chaudhury, Deepak Chellapandian, Alfred P Gillio, Fredrick Goldman, Harry L Malech, Kenneth Desantes, Geoff D E Cuvelier, Jacob Rozmus, Ralph Quinones, Lolie C Yu, Larisa Broglie, Victor Aquino, Evan Shereck, Theodore B Moore, Mark T Vander Lugt, Talal I Mousallem, Joeseph H Oved, Morna Dorsey, Hisham Abdel-Azim, Caridad Martinez, Jacob H Bleesing, Susan Prockop, Donald B Kohn, Jeffrey J Bednarski, Jennifer Leiding, Rebecca A Marsh, Troy Torgerson, Luigi D Notarangelo, Sung-Yun Pai, Michael A Pulsipher, Jennifer M Puck, Christopher C Dvorak, Elie Haddad, Rebecca H Buckley, Morton J Cowan, Jennifer Heimall

Faculty, Staff and Students Publications

Background: The Primary Immune Deficiency Treatment Consortium (PIDTC) enrolled children in the United States and Canada onto a retrospective multicenter natural history study of hematopoietic cell transplantation (HCT).

Objective: We investigated outcomes of HCT for severe combined immunodeficiency (SCID).

Methods: We evaluated the chronic and late effects (CLE) after HCT for SCID in 399 patients transplanted from 1982 to 2012 at 32 PIDTC centers. Eligibility criteria included survival to at least 2 years after HCT without need for subsequent cellular therapy. CLE were defined as either conditions present at any time before 2 years from HCT that remained unresolved (chronic), …

Insights Into Child Abuse And Neglect: Findings From The Minnesota Longitudinal Study Of Risk And Adaptation, Marissa D. Nivison, Madelyn H. Labella, K. Lee Raby, Jenalee R. Doom, Jodi Martin, William F. Johnson, Osnat Zamir, Michelle M. Englund, Jeffry A. Simpson, Elizabeth A. Carlson, Glennn I. Roisman

Psychology Faculty Publications

The Minnesota Longitudinal Study of Risk and Adaptation (MLSRA) is a landmark prospective, longitudinal study of human development focused on a sample of mothers experiencing poverty and their firstborn children. Although the MLSRA pioneered a number of important topics in the area of social and emotional development, it began with the more specific goal of examining the antecedents of child maltreatment. From that foundation and for more than 40 years, the study has produced a significant body of research on the origins, sequelae, and measurement of childhood abuse and neglect. The principal objectives of this report are to document the …

Sleep Disturbances And Psychological Well-Being Among Military Medical Doctors Of The Swiss Armed Forces: Study Protocol, Rationale And Development Of A Cross-Sectional And Longitudinal Interventional Study, Dena Sadeghi-Bahmani, Viola Rigotti, Zeno Stanga, Undine E. Lang, Rebecca K. Blais, Michelle L. Kelley, Serge Brand

Psychology Faculty Publications

Background: Compared to civilians and non-medical personnel, military medical doctors are at increased risk for sleep disturbances and impaired psychological well-being. Despite their responsibility and workload, no research has examined sleep disturbances and psychological well-being among the medical doctors (MDs) of the Swiss Armed Forces (SAF). Thus, the aims of the proposed study are (1) to conduct a cross-sectional study (labeled ‘Survey-Study 1’) of sleep disturbances and psychological well-being among MDs of the SAF; (2) to identify MDs who report sleep disturbances (insomnia severity index >8), along with low psychological well-being such as symptoms of depression, anxiety and stress, but …

Expanding A Behavioral View On Digital Health Access: Drivers And Strategies To Promote Equity, Maura M. Kepper, Lauren A. Fowler, Isabelle S. Kusters, Jean W. Davis, Manal Baqer, Sarah Sagui-Henson, Yunyu Xiao, Adati Tarfa, Jean C. Yi, Bryan Gibson, Kristin E. Heron, Nicole M. Alberts, Marissa Burgermaster, Veronica Njie-Carr, Lisa M. Klesges

Psychology Faculty Publications

The potential and threat of digital tools to achieve health equity has been highlighted for over a decade, but the success of achieving equitable access to health technologies remains challenging. Our paper addresses renewed concerns regarding equity in digital health access that were deepened during the COVID-19 pandemic. Our viewpoint is that (1) digital health tools have the potential to improve health equity if equitable access is achieved, and (2) improving access and equity in digital health can be strengthened by considering behavioral science-based strategies embedded in all phases of tool development. Using behavioral, equity, and access frameworks allowed for …

In Sickness And In Health-Type I Interferon And The Brain, Wei Cao

Faculty, Staff and Student Publications

Type I interferons (IFN-I) represent a group of pleiotropic cytokines renowned for their antiviral activity and immune regulatory functions. A multitude of studies have unveiled a critical role of IFN-I in the brain, influencing various neurological processes and diseases. In this mini-review, I highlight recent findings on IFN-I's effects on brain aging, Alzheimer's disease (AD) progression, and central nervous system (CNS) homeostasis. The multifaceted influence of IFN-I on brain health and disease sheds light on the complex interplay between immune responses and neurological processes. Of particular interest is the cGAS-STING-IFN-I axis, which extensively participates in brain aging and various forms …

Centering Veg*Ns Of Color: An Intersectional Imperative To Anti-Veg*N Stigma, Caitlin M. Mercier

Faculty Publications – Psychology

Veg*ns of color continue to be underrepresented with their health less understood in veg*n scholarship. As intersectionality and health outcomes remain an understudied focus in anti-veg*n scholarship, the concealable stigmatized identity (CSI) framework offers a way to identify the link between stigmatization and health outcomes for VOC. Using the CSI framework, the paper provides a review of multilevel manifestations of anti-veg*n stigmatization in previous and current veg*n scholarship. The paper offers future directions for researchers to examine stigmatization and its impact on VOC. Recommendations are provided to generate knowledge about the experiences and health of VOC.

Lifestyle Management Of Hypertension: International Society Of Hypertension Position Paper Endorsed By The World Hypertension League And European Society Of Hypertension, Fadi J Charchar, Priscilla R Prestes, Charlotte Mills, Siew Mooi Ching, Dinesh Neupane, Francine Z Marques, James E Sharman, Liffert Vogt, Louise M Burrell, Lyudmila Korostovtseva, Manja Zec, Mansi Patil, Martin G Schultz, Matthew P Wallen, Nicolás F Renna, Sheikh Mohammed Shariful Islam, Swapnil Hiremath, Tshewang Gyeltshen, Yook-Chin Chia, Abhinav Gupta, Aletta E Schutte, Britt Klein, Claudio Borghi, Colette J Browning, Marta Czesnikiewicz-Guzik, Hae-Young Lee, Hiroshi Itoh, Katsuyuki Miura, Mattias Brunström, Norm R C Campbell, Olutope Arinola Akinnibossun, Praveen Veerabhadrappa, Richard D Wainford, Ruan Kruger, Shane A Thomas, Takahiro Komori, Udaya Ralapanawa, Véronique A Cornelissen, Vikas Kapil, Yan Li, Yuqing Zhang, Tazeen H Jafar, Nadia Khan, Bryan Williams, George Stergiou, Maciej Tomaszewski

Faculty, Staff and Student Publications

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on …

Children's Nature Play: Access To The Outdoors And Interactions With Biodiversity, Allison Antink-Meyer, Anthony W. Lorsbach, Ryan A. Brown

Faculty Publications - College of Education

In the U.S. and elsewhere, the nature play and outdoor time that is important to childhood development is not accessible to many. Children’s interactions with elements of nature, including biodiversity, are important. This study explored community-based affordances, using a nature play continuum, to examine the wildness in specific space types. To investigate children’s access and uncover how they interacted with nature in specific types of outdoor spaces, two iterations of household surveys for 489 families were used in the study. Underlying associations between types of outdoor space and children’s access were found. Direct and intentional interactions with biodiversity were related …

Dietary Practices Among Type 2 Diabetes Patients Visiting A Non-Communicable Disease (Ncd) Clinic In A District Of Western India: A Cross-Sectional Study, Bela Patel, Sumit Unadkat, Harsh Patel, Mittal Rathod

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: Diabetes is becoming a major public health problem in the country. One of the most important lifestyle modifications necessary for diabetic patients is maintaining healthy dietary choices. These modifications in dietary practices are supposed to be followed lifelong, along with medication, for better glycemic control. Despite understanding the importance of dietary control and physical activity in the management of diabetes, adherence to these practices is poor. This study aimed to assess the dietary practices of type 2 diabetes mellitus (T2DM) patients and various factors that determine adherence to these healthy dietary practices. The secondary objective was to …

Pregnancy-Related Factors Responsible For Delivering Low Birth Weight Babies: An Institutional-Based Cross-Sectional Study, Jamnagar, Gujarat, Harsh K Patel, Jitesh P Mehta, Bela A Patel, Rohitkumar Ram, Dipesh V Parmar

Faculty, Staff and Student Publications

BACKGROUND: The WHO defines LBW as "Birth weight less than 2500 grams" regardless of gestational age. Being born with a low birth weight also incurs enormous economic costs, including higher medical expenditures and social service expenses, and decreased productivity in adulthood.

OBJECTIVE: To study distribution of newborns' according to pregnancy related factors and its association with newborns' birth weight.

METHODS: An institutional based cross-sectional study. New-borns delivered at study institute were considered as study participants. Estimated final sample size was 500. Guardians (mothers) were face-to-face interviewed and also recorded data were collected from the case file and Mother and Child …

Hepatic Failure And Hyperbilirubinemia Secondary To Hemolytic Disease Of The Newborn, Matthew Reinhardt, Marya L Strand, Dajana Sabic

Faculty, Staff and Students Publications

Anti-D antibody is the most common cause of hemolytic disease of the newborn (HDN). Other antigens have emerged, causing significant damage to the newborn. We report a case of a 31-week dichorionic diamniotic twin born emergently to a mother with anti-C and anti-D antibodies who required multiple percutaneous umbilical cord blood sampling (PUBS) and transfusions. Extensive resuscitation at birth was required due to severe anemia, hypovolemia, and prematurity. Ensuing liver damage occurred with subsequent profound coagulopathy, transaminitis, and direct hyperbilirubinemia that required significant support. This patient developed several unique findings including the inability to monitor oxygen saturations due to dermal …

Mecp2-Related Disorders While Gene-Based Therapies Are On The Horizon, Katherine Allison, Mirjana Maletic-Savatic, Davut Pehlivan

Faculty, Staff and Students Publications

The emergence of new genetic tools has led to the discovery of the genetic bases of many intellectual and developmental disabilities. This creates exciting opportunities for research and treatment development, and a few genetic disorders (e.g., spinal muscular atrophy) have recently been treated with gene-based therapies. MECP2 is found on the X chromosome and regulates the transcription of thousands of genes. Loss of MECP2 gene product leads to Rett Syndrome, a disease found primarily in females, and is characterized by developmental regression, motor dysfunction, midline hand stereotypies, autonomic nervous system dysfunction, epilepsy, scoliosis, and autistic-like behavior. Duplication of MECP2 causes …

Polygenic Scores And Mendelian Randomization Identify Plasma Proteins Causally Implicated In Alzheimer’S Disease, Davis B Cammann, Yimei Lu, Jerome I Rotter, Alexis C Wood, Jingchun Chen

Faculty, Staff and Students Publications

BACKGROUND: An increasing body of evidence suggests that neuroinflammation is one of the key drivers of late-onset Alzheimer's disease (LOAD) pathology. Due to the increased permeability of the blood-brain barrier (BBB) in older adults, peripheral plasma proteins can infiltrate the central nervous system (CNS) and drive neuroinflammation through interactions with neurons and glial cells. Because these inflammatory factors are heritable, a greater understanding of their genetic relationship with LOAD could identify new biomarkers that contribute to LOAD pathology or offer protection against it.

METHODS: We used a genome-wide association study (GWAS) of 90 different plasma proteins (

RESULTS: We identified …

Effects Of Blood Flow Restriction Resistance Training On Autonomic And Endothelial Function In Persons With Parkinson's Disease, Annie Bane, Lorraine Wilson, Jill Jumper, Lindsay Spindler, Pricilla Wyatt, Darryn Willoughby

Faculty, Staff and Students Publications

Background: Autonomic dysfunction precedes endothelial dysfunction in Parkinson's disease (PD) and causes blood pressure and circulation abnormalities that are highly disruptive to one's quality of life. While exercise interventions have proven helpful for motor symptoms of PD, improving associated non-motor symptoms is limited. Low-intensity resistance training with blood flow restriction (LIRT-BFR) improves autonomic dysfunction in non-PD patients and high-intensity resistance training (HIRT) is recommended for motor symptom improvements for people with PD (PwPD).

Objective: To determine the effects of LIRT-BFR and HIRT on homocysteine and autonomic and endothelial function in PwPD and to determine the hemodynamic loads during LIRT-BFR and …

Liver Directed Adeno-Associated Viral Vectors To Treat Metabolic Disease, Marcel A Chuecos, William R Lagor

Faculty, Staff and Students Publications

The liver is the metabolic center of the body and an ideal target for gene therapy of inherited metabolic disorders (IMDs). Adeno-associated viral (AAV) vectors can deliver transgenes to the liver with high efficiency and specificity and a favorable safety profile. Recombinant AAV vectors contain only the transgene cassette, and their payload is converted to non-integrating circular double-stranded DNA episomes, which can provide stable expression from months to years. Insights from cellular studies and preclinical animal models have provided valuable information about AAV capsid serotypes with a high liver tropism. These vectors have been applied successfully in the clinic, particularly …

Fluoxetine And Sertraline Inhibit Height Growth And Growth Hormone Signaling During Puberty, Chadi Calarge, Chima Amushie, Stephanie Dinh, James A Mills, Sridevi Devaraj, Griselda Barba-Villalobos, Jacqueline Nguyen, Jose M Garcia, Stephanie Sisley, Fida Bacha, Babette Zemel

Faculty, Staff and Students Publications

Purpose: The aim of this study was to examine the effect of fluoxetine and sertraline on height growth and insulin-like growth factor-1 (IGF-1) during puberty.

Methods: In this 6-month cohort study, electronic medical records were used to identify 8- to 15-year-old participants, within 1 month of starting fluoxetine (n = 39) or sertraline (n = 27), and sexual maturation stages 2 to 4 were confirmed. Conditions that interfere with height growth led to exclusion. Participants underwent anthropometric assessments and phlebotomy. Healthy, unmedicated children (n = 36) also provided anthropometric data.

Results: After the baseline height Z-score, sex, Tanner stage, daily …

The Maternal Gut Microbiome In Pregnancy: Implications For The Developing Immune System, Omry Koren, Liza Konnikova, Petter Brodin, Indira U Mysorekar, Maria Carmen Collado

Faculty, Staff and Students Publications

The gut microbiome has important roles in host metabolism and immunity, and microbial dysbiosis affects human physiology and health. Maternal immunity and microbial metabolites during pregnancy, microbial transfer during birth, and transfer of immune factors, microorganisms and metabolites via breastfeeding provide critical sources of early-life microbial and immune training, with important consequences for human health. Only a few studies have directly examined the interactions between the gut microbiome and the immune system during pregnancy, and the subsequent effect on offspring development. In this Review, we aim to describe how the maternal microbiome shapes overall pregnancy-associated maternal, fetal and early neonatal …

Desert Or Mirage? An Examination Of Food Deserts In Iowa Cities, Andrew Creasey

Graduate Research Papers

Food insecurity affects millions of Americans and has been widely recognized as a significant health and economic issue. Because of this, researchers have sought to develop ways to identify areas that are prone to food insecurity, which have become known as food deserts. Food deserts have been broadly defined through a confluence of three factors: low income, a lack of vehicle access, and a predetermined distance from a healthy food retailer. But research into food deserts in Iowa is limited, and the most prominent source of information on this topic, the Food Access Research Atlas created by the U.S. Department …

Covid-19 Vaccination-Related Tinnitus Is Associated With Pre-Vaccination Metabolic Disorders, Weihua Wang, Anusha Yellamsetty, Robert M. Edmonds, Shaun R. Barcavage, Shaowen Bao

Faculty Research, Scholarly, and Creative Activity

Cases of tinnitus have been reported following administration of COVID-19 vaccines. The aim of this study was to characterize COVID-19 vaccination-related tinnitus to assess whether there is a causal relationship, and to examine potential risk factors for COVID-19 vaccination-related tinnitus. We analyzed a survey on 398 cases of COVID-19 vaccination-related tinnitus, and 699,839 COVID-19 vaccine-related reports in the Vaccine Adverse Effect Reporting System (VAERS) database that was retrieved on 4 December 2021. We found that following COVID-19 vaccination, 1) tinnitus report frequencies for Pfizer, Moderna and Janssen vaccines in VAERS are 47, 51 and 70 cases per million full vaccination; …

Opening The Black Box: Carbon-Footprint Calculators, Meat Consumption, And The “Wicked Problem” Of Metric Governance, E. Melanie Dupuis, Dustin Mulvaney

Faculty Research, Scholarly, and Creative Activity

Carbon-footprint calculators are widely used as communication and education tools, designed to make people aware of the ways their personal actions contribute to greenhouse-gas emissions. However, they have come under criticism for emphasizing individual behavior versus structural change. We extend this critique to argue that carbon-footprint calculators are a form of “metric governance” that not only disciplines users but also constrains their abilities to engage with the complexities of climate change and social action. We focus on a particularly wicked problem of carbon-metric governance: livestock greenhouse-gas emissions. We show that carbon-footprint calculators black box and fix the complex politics and …

Effect Of Fermentation, Malting And Ultrasonication On Sorghum, Mopane Worm And Moringa Oleifera: Improvement In Their Nutritional, Techno-Functional And Health Promoting Properties, Mpho Sebabiki Maleke, Oluwafemi Ayodeji Adebo, Jonathan Wilkin, Moira Ledbetter, Xi Feng, John Gieng, Tumisi Beiri Jeremiah Molelekoa

Faculty Research, Scholarly, and Creative Activity

Background: Food processing offers various benefits that contribute to food nutrition, food security and convenience. This study investigated the effect of three different processes (fermentation, malting and ultrasonication) on the nutritional, techno-functional and health-promoting properties of sorghum, mopane worm and Moringa oleifera. Methods: The fermented and malted flours were prepared at 35°C for 48 h, and for ultrasonication, samples were subjected to 10 min at 4°C with amplitudes of 40–70 Hz. The biochemical, nutritional quality and techno-functional properties of the obtained flours were analysed using standard procedures. Results: Fermentation resulted in significantly lower pH and higher titratable acidity in sorghum …

Poor Nutrition Status Associated With Low Patient Satisfaction Six Months Into Treatment For Head And Neck/Esophageal Cancer Treatment: A Prospective Multicenter Cohort Study, Adrianne M. Widaman, Andrew G. Day, Maggie A. Kuhn, Rupinder Dhaliwal, Vickie Baracos, Merran Findlay, Judith D. Bauer, Marian De Van Der Schueren, Alessandro Laviano, Lisa Martin, Leah Gramlich

Faculty Research, Scholarly, and Creative Activity

Background: Patient-reported outcome measures have been associated with survival in oncology patients. Altered intake and malnutrition are common symptoms for patients treated for head and neck cancer and esophageal cancer (HNC/EC). The purpose of this study was to examine the relationship between patient-reported satisfaction with medical care and nutrition status. Methods: This prospective cohort study collected data from 11 international cancer care sites. Results: One hundred and sixtythree adult patients (n = 115 HNC; n = 48 EC) completed a patient satisfaction questionnaire (the Canadian Health Care Evaluation Project Lite) and were included. HNC/EC patient global satisfaction with medical care …

Public Libraries Encouraged To Meet The Health Information Needs Of Tribal Women In Bangladesh, Lili Luo

Faculty Research, Scholarly, and Creative Activity

Objective – To investigate public libraries’ existing community engagement practices, explore their willingness to provide health information services to tribal communities in Bangladesh, and examine tribal women’s health information-seeking behavior and interest in obtaining health information from public libraries. Design – A cross-sectional study using online interviews and structured questionnaires. Setting – Public libraries and tribal communities in tribal regions of Bangladesh. Subjects – Public librarians (n=11) and tribal women (n=276) from three tribal districts in Bangladesh (Bandarban, Khagrachari, and Mymensingh). Methods – Interviews were conducted with librarians via Zoom in January 2023. Survey questionnaires were distributed to a convenience …

Sample Sizes For 10 Types Of Qualitative Data Analysis: An Integrative Review, Empirical Guidance, And Next Steps, Amber Wutich, Melissa Beresford, H. Russell Bernard

Faculty Research, Scholarly, and Creative Activity

There has been a recent explosion of articles on minimum sample sizes needed for analyzing qualitative data. The purpose of this integrated review is to examine this literature for 10 types of qualitative data analysis (5 types of saturation and 5 common methods). Building on established reviews and expanding to new methods, our findings extract the following sample size guidelines: theme saturation (9 interviews; 4 focus groups), meaning saturation (24 interviews; 8 focus groups), theoretical saturation (20–30+ interviews), metatheme saturation (20–40 interviews per site), and saturation in salience (10 exhaustive free lists); two methods where power analysis determines sample size: …

Pacing Beside The Pool: Coaching Champion Writers To A Strong Finish In Clinic (Without Jumping In And Finishing For Them), Hillary A. Wandler

Faculty Law Review Articles

No abstract provided.

The Role Of Paradata In Algorithmic Accountability, Ciaran B. Trace, James A. Hodges

Faculty Research, Scholarly, and Creative Activity

This chapter examines how the doings of the algorithm (instantiated through its operations, actions, and steps) and its accompanying algorithmic system are revealed and explored through an engagement with the paradata created as a part of this data-making effort. In doing so, the chapter explores how the concept of paradata helps us understand how information professionals and domain stakeholders conceptualize accountable algorithmic entities and how this influences how they emerge as documented and describable entities. Two complementary frameworks for capturing and preserving paradata for accountability purposes are examined in the process. The first is associated with diplomatic theory and archival …

Potential Use Of Poultry Farms By Wild Waterfowl In California's Central Valley Varies Across Space, Times Of Day, And Species: Implications For Influenza Transmission Risk, Claire S. Teitelbaum, Michael L. Casazza, Cory T. Overton, Jeffery D. Sullivan, Elliott L. Matchett, Fiona Mcduie, Austen A. Lorenz, Joshua T. Ackerman, Susan E.W. De La Cruz, Diann J. Prosser

Faculty Research, Scholarly, and Creative Activity

Interactions between wildlife and livestock can lead to cross-species disease transmission, which incurs economic costs and threatens wildlife conservation. Wild waterfowl are natural hosts of avian influenza viruses (AIVs), are often abundant near poultry farms, and have been linked to outbreaks of AIVs in poultry. Interspecific and seasonal variation in waterfowl movement and habitat use means that the risk of disease transmission between wild birds and poultry inevitably varies across species, space, and time. Here, we used GPS telemetry data from 10 waterfowl species in and near California's Central Valley, a region where both wild waterfowl and domestic poultry are …