Digital Commons Network^™

Investigation Of Setmelanotide, An Mc4r Agonist, For Obesity In Individuals With Smith-Magenis Syndrome, Julia Lazareva, Stephanie R Sisley, Sheila M Brady, Ann C M Smith, Sarah H Elsea, Jeremy J Pomeroy, Christian L Roth, Jennifer E Sprague, Martin Wabitsch, Jill Garrison, Jack A Yanovski

Children’s Nutrition Research Center Staff Publications

Background: Smith Magenis Syndrome (SMS) is a rare genetic disorder caused by RAI1 haploinsufficiency. Obesity in people with SMS is believed partially due to dysfunction of the proximal melanocortin 4 receptor (MC4R) pathway. We therefore studied effects of treatment with the MC4R agonist setmelanotide on obesity and hunger, as well as metabolic, cardiac and safety, in individuals with SMS.

Methods: People with SMS received once-daily setmelanotide injections, with the dose titrated bi-weekly to a maximum of 3 mg over ∼1 month; and a full-dose treatment duration of 3mo. The primary outcome was percent change in body weight. Secondary outcomes included …

Examining Ghana's National Health Insurance Act, 2003 (Act 650) To Improve Accessibility Of Artificial Intelligence Therapies And Address Compensation Issues In Cases Of Medical Negligence, George Benneh Mensah, Maad M. Mijwil, Mostafa Abotaleb

Mesopotamian Journal of Computer Science

Objective: Examine Ghana’s National Health Insurance Act (Act 650) to identify coverage gaps limiting artificial intelligence (AI) therapy access and address medical negligence liability issues surrounding automated healthcare systems. Methods: Legal and regulatory analysis of Act 650 were conducted, review of academic literature on global uptake of AI interventions and medical negligence principles were elucidated, examination of case studies implementing pilot AI therapy programs under insurance schemes were considered. Results & Conclusions: Act 650 lacks clear provisions for funding innovative AI treatments with proven efficacy and undefined negligence determination guidelines involving AI systems, contributing to accessibility and accountability issues. Proposed …

Potato Disease Identification Using Transfer Learning Approaches, Tarza Hasan Abdullah

Mesopotamian Journal of Computer Science

Potato crop is one of the prominent consumed foods by human beings. When potato crops are infected by diseases it affects farmers negatively and to run in a loss. Therefore, early detection of the potato crop disease can play a vital role in minimizing the loss of the farmers. Nowadays, artificial intelligence technologies, more specifically deep learning techniques, provide solutions to many crops disease-related problems. However, training deep learning models requires a high computational power and huge amount of data as they are data hungry models. Also, designing a custom CNN models a difficult task and there are some variations …

K-Perm: Personalized Response Generation Using Dynamic Knowledge Retrieval And Persona-Adaptive Queries, Kanak Raj, Kaushik Roy, Vamshi Bonagiri, Priyanshul Govil, Krishnaprasad Thirunarayan, Raxit Goswami, Manas Gaur

Publications

Personalizing conversational agents can enhance the quality of conversations and increase user engagement. However, they often lack external knowledge to tend to a user’s persona appropriately. This is particularly crucial for practical applications like mental health support, nutrition planning, culturally sensitive conversations, or reducing toxic behavior in conversational agents. To enhance the relevance and comprehensiveness of personalized responses, we propose using a two-step approach that involves (1) selectively integrating user personas and (2) contextualizing the response with supplementing information from a background knowledge source. We develop K-PERM (Knowledge-guided PErsonalization with Reward Modulation), a dynamic conversational agent that combines these elements. …

Growing South Dakota (Winter 2024), College Of Agriculture, Food And Environmental Sciences

Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)

[Page] 3 Continuing a Leadership Journey
/="/">[Page] 5 CAFES Leadership Team Grows
/="/">[Page] 7 Award-Winning Faculty & Staff
/="/">[Page] 9 New Endowment Holders Recognized
/="/">[Page] 10 Inaugural Precision Livestock Field School Offered at SDSU Cottonwood Field Station
/="/">[Page] 11 SDSU Celebrates Professional Program in Veterinary Medicine Students [Page] 13 Clay Carlson, SDSU Meat Science Graduate Student Approaches School and Life with Winning Mindset
/="/">[Page] 15 SDSU Alumni has been selected as the Head Coach of the South Dakota State University Livestock Judging Team
/="/">[Page] 16 Livestock Units Promote Hands-On Learning & Premier Research …

Setting The Foundation For A Lifetime Of Oral Health, Samuel Blanchard Dds, Ms

The Journal of the Michigan Dental Association

In this Children’s Dental Health Month article, the Michigan Academy of Pediatric Dentistry emphasizes the crucial role of relationships and trust in pediatric dentistry. Highlighting the significance of collaborative efforts between dental societies, the commentary discusses the impact of professional connections on patient care. The author shares personal insights on transitioning in their career, underscoring the value of cultivated relationships. The age-1 dental visit is highlighted as a powerful preventive measure to establish rapport and empower parents with oral health knowledge. The article emphasizes the enduring benefits of building connections in promoting lifelong oral health.

Emphasizing Self-Regulation In Teaching: Reducing Disruption To Students’ Learning During Unplanned Instructional Mode Transition, Somesh Roy, Amber Young-Brice, Jenna Lassila, Brandon Kyle Johnson

College of Nursing Faculty Research and Publications

In Spring 2020, engineering faculty transitioned to emergency remote instruction due to COVID-19. This mixed-methods study was done to understand the correlation between self-regulated learning and how students experienced the emergency transition to remote learning. The participants were from an upper-level engineering course, with 33 students surveyed four times during the semester. Seven students were interviewed after the semester. Findings revealed that during the transition to remote learning, students perceived less change if they had higher degrees of self-regulation. The qualitative analysis also revealed that transparency in learning and teaching also played an important role in students’ perceptions.

Newborn Screening Analytes And Structural Birth Defects Among 27,000 Newborns, Philip J Lupo, Natalie P Archer, Rachel D Harris, Lisa K Marengo, Jeremy M Schraw, Adrienne T Hoyt, Susan Tanksley, Rachel Lee, Margaret Drummond-Borg, Debra Freedenberg, Priya B Shetty, A J Agopian, Charles Shumate, Sonja A Rasmussen, Peter H Langlois, Mark A Canfield

Center for Medical Ethics and Health Policy Staff Publications

Background: Emerging evidence suggests newborn screening analytes may yield insights into the etiologies of birth defects, yet no effort has evaluated associations between a range of newborn screening analytes and birth defects.

Methods: This population-based study pooled statewide data on birth defects, birth certificates, and newborn screening analytes from Texas occurring between January 1, 2007 and December 31, 2009. Associations between a panel of thirty-six newborn screening analytes, collected by the statewide Texas Newborn Screening Program, and the presence of a birth defect, defined as at least one of 39 birth defects diagnoses recorded by the Texas Birth Defects Registry, …

Cardiovascular Disease In Firefighters, Emily Jordan Baldwin

Doctor of Nursing Practice Projects

This quality improvement project aimed to address the problem of increased cardiovascular events in firefighters in a county in the foothills of North Carolina. Nola Pender and Dorothy Orem’s theories were utilized for this project. The literature review exhibits the prevalence and significance of cardiovascular disease in firefighters. The literature review demonstrates the benefits healthy eating and exercise have on the heart and towards the prevention of cardiovascular disease. A pre- and post-test was utilized for this project and allowed for the collection of data appropriately. The results showed education on cardiovascular disease, exercise, and healthy eating increased the knowledge …

Essential Collaborations Among Case Managers And Providers Regarding Discharge Processes, Lashawnda Richardson

Doctor of Nursing Practice Projects

Communication is vital between case managers and providers when patients need care coordination post-discharge. This includes but is not limited to facilitating home health services, ordering durable medical equipment, sending referrals to rehabilitation facilities, and sponsorship for uninsured or underinsured patients. This gives case managers the opportunity to educate providers on the discharge needs they ordered for their patients. The collaboration between case managers and providers allows for timely discharge planning and providing patients and their families with accurate information regarding their discharge needs.

Remodeling Breastfeeding Education, Rhonda Coffey

Doctor of Nursing Practice Projects

Mothers face important decisions regarding how to feed their infants, and successful breastfeeding requires commitment, support, and education. The numerous health benefits of breastfeeding for both mothers and infants are well-documented throughout the literature, and experts recommend exclusive breastfeeding for the first year of life. Healthcare teams play a crucial role in supporting breastfeeding success by providing education, guidance, and troubleshooting assistance when complications arise. Reassurance from healthcare providers can also influence mothers' overall experiences with breastfeeding. The facility where participants deliver assists most mothers in initiating breastfeeding within 1 to 2 hours after delivery, with approximately 75% meeting this …

Healthcare Marketing Communication: Media Usage And Psychographic Profiles For Baby Boomer, Gen X, And Millennial Consumers, Terry Damron, Joe Cangelosi, David Kim, Ed Ranelli

Atlantic Marketing Journal

Abstract

Purpose Preventive health care information (PHCI), which functions as a cost-effective or cost-saving means of reducing mortality and improving life quality, also fuels consumer demand for otherwise underutilized preventive medical services, thereby improving profitability for service providers. This study provides healthcare marketing professionals with media usage insights and psychographic profiles useful for developing effective PHCI communication strategies.

Design This research is based on questionnaire responses (n = 813). Analysis of the variance (ANOVA) was used to assess and compare the importance consumers assigned to online PHCI sources. Factor analysis was used to determine whether attitude patterns tended to …

Essential Omega‐3 Fatty Acids Are Depleted In Sea Ice And Pelagic Algae Of The Central Arctic Ocean, Katrin Schmidt, Martin Graeve, Clara J.M. Hoppe, S Torres‐Valdes, Nahid Welteke, Laura M. Whitmore, Philipp Anhaus, Angus Atkinson, Simon T. Belt, Tina Brenneis, Robert G. Campbell, Giulia Castellani, Louise A. Copeman, Hauke Flores, Allison A. Fong, Nicole Hildebrandt, Doreen Kohlbach, Jens M. Nielsen, Christopher C. Parrish, C Rad‐Menéndez, Sebastian D. Rokitta, Sandra Tippenhauer, Yanpei Zhuang

School of Geography, Earth and Environmental Sciences

Microalgae are the main source of the omega‐3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), essential for the healthy development of most marine and terrestrial fauna including humans. Inverse correlations of algal EPA and DHA proportions (% of total fatty acids) with temperature have led to suggestions of a warming‐induced decline in the global production of these biomolecules and an enhanced importance of high latitude organisms for their provision. The cold Arctic Ocean is a potential hotspot of EPA and DHA production, but consequences of global warming are unknown. Here, we combine a full‐seasonal EPA and DHA dataset …

Pancreatoduodenectomy For Malignancy: Factors Influencing Surgical And Oncological Outcomes, Thomas Brendon Russell

Peninsula Medical School Theses

Introduction: Fit patients with a resectable pancreatic head adenocarcinoma (PDAC), ampullary adenocarcinoma (AA) or distal cholangiocarcinoma (CC) may be offered pancreatoduodenectomy (PD) with curative-intent. However, perioperative morbidity and cancer recurrence rates are high. This thesis aimed to explore the factors influencing PD outcomes. A focus was placed on nutrition, postoperative complications, and recurrence in AA patients. It is hoped the findings will guide patient selection/consenting and have implications for patient management. Methods: A retrospective cohort study of patients who underwent PD for histologically-confirmed malignancy was carried out (2012-2015). Twenty-nine centres from eight countries were involved. Data on the following were …

Associations Between Fatigue Impact And Physical And Neurobehavioural Factors: An Exploration In People With Progressive Multiple Sclerosis, L Connolly, S Chatfield, J Freeman, A Salter, Mp Amato, G Brichetto, J Chataway, Nd Chiaravalloti, G Cutter, J Deluca, U Dalgas, R Farrell, P Feys, M Filippi, M Inglese, C Meza, Nb Moore, Rw Motl, Ma Rocca, Bm Sandroff, A Feinstein

School of Health Professions

Background: Fatigue is common in people with multiple sclerosis (MS). Understanding the relationship between fatigue, physical and neurobehavioural factors is important to inform future research and practice. Few studies explore this explicitly in people with progressive MS (pwPMS). Objective: To explore relationships between self-reported fatigue, physical and neurobehavioural measures in a large, international progressive MS sample of cognitively impaired people recruited to the CogEx trial. Methods: Baseline assessments of fatigue (Modified Fatigue Impact Scale; MFIS), aerobic capacity (VO _2peak), time in moderate-vigorous physical activity (MVPA; accelerometery over seven-days), walking performance (6-minute walk test; 6MWT), self-reported walking difficulty (MS Walking …

Selective Fast Fiber Damage After Leg Press Exercise Leading To Failure: A Pole Vaulter Case Report, Gerard Carmona, Gerard Moras, Raúl Bescós, Adrián García-Fresneda, Joan A. Cadefau

School of Health Professions

The aim of this study was to investigate, in a trained pole vaulter (PV) and in an endurance-trained physical education student (PE), the effect of a leg press exercise leading to failure (LPF) on changes in serum activity of muscle enzymes and serum concentration of fast (FM) and slow (SM) myosin isoforms, while simultaneously examining mechanical output components as indicators of performance and fatigue developed throughout exercise. A case report study design based on an observational comparison of response between two dichotomous participants, PV and PE, was used. Differences between the participants’ exercise outputs were examined by unpaired t-test or …

Navigating The Complexity Of Applying Nutrition Evidence To Individualised Care: Summary Of An Academy Of Nutrition Sciences Position Paper, Judith Buttriss, Mary Hickson, Kevin Whelan, Christine Williams

School of Health Professions

Diet is key to the maintenance of health and crucial in the prevention and management of many diseases. Modified nutrient intake may become essential to prevent deficiency, optimise development and health or manage symptoms and disease progression. Adding to the complexity, disease and its treatment can also affect taste, appetite and ability to access and prepare foods. Coupled with this, individual requirements for energy, macronutrients and micronutrients are influenced by factors such as life stage (age, growth, pregnancy, etc.) and health status, which can affect the processes of consuming, digesting, absorbing, metabolising or excreting nutrients. First and foremost, dietary advice …

Guidelines For Protecting And Promoting Decapod Crustacean Welfare In Research, Mark Briffa

School of Biological and Marine Sciences

The decapod order contains ~15,000 species, including crabs, lobsters, crayfish, prawns, and shrimps. The idea that these animals might experience pain was long dismissed because they were thought to respond to noxious stimuli and tissue damage purely by nociceptive reflex—a position questioned by Sherwin (2001). Later experimental studies demonstrated that their responses were complex, long-lasting, and largely consistent with criteria for pain that had been produced initially for vertebrates (Elwood 2019). While the nature and extent of potential sentience in decapods remains an active area of research, these animals were recently recognized as sentient for the purposes of UK law, …

Lessons Learned: Facilitating A Health And Wellness Intervention For Frontline Child Welfare Workers During Covid-19, Kara Haughtigan, Austin Griffiths, Kim Link, Oliver Beer, Lindsey Powell

School of Health Professions

Child maltreatment is one of the nation’s most significant public health concerns. The estimated annual economic burden of child maltreatment in the United States is more than $292 billion (Peterson et al., 2018). In 2021, approximately four million referrals were made to child protective service agencies alleging the maltreatment of more than seven million children (U.S. Department of Health and Human Services [HHS], 2023). The primary mechanism for evaluating these referrals is the frontline child welfare workforce. Frontline child welfare workers (FCWWs) engage families and make decisions about the safety of children that directly impact children’s futures (Edwards & Wildeman, …

The Early Prevention Of Diabetic Foot Ulcers, Aruodo Ukpai

Doctor of Nursing Practice Projects

Frequent and proper foot exams and foot care are fundamental in decreasing the incidence and morbidity of diabetic foot ulcers, yet many patients are still not screened at appointments or educated on the importance of foot exams. This research planned to address the lack of foot care education and foot assessments amongst patients with Type 2 diabetes. Past research done on this focused on providing education to diabetic patients either at home or in a setting where patients can come and receive the education. To our knowledge, no research has been done on the use of video teaching to provide …

Benefits Of Patient-Centered Education For Type 2 Diabetes Mellitus, Paige Bortnick

Doctor of Nursing Practice Projects

Type 2 diabetes is a chronic, lifelong illness that affects millions of individuals in the United States. The rate of diabetes has doubled over the last 20 years in America and has climbed to be the seventh leading cause of death amongst Americans. The purpose of this project was to determine if participants in the target community demonstrated increased knowledge and awareness of diabetes after receiving education. A pre-intervention and post-intervention survey was given to determine if the education was effective. Data collected revealed an increased awareness and knowledge regarding the prevalence of type 2 diabetes, lifestyle, and diet modification.

Community Education: Impact On Earlier Recognition Of Stroke, Lauren Kahn

Doctor of Nursing Practice Projects

Cerebrovascular disease was identified as the fourth leading cause of death in Cleveland County, North Carolina from 2014 to 2018 (Cleveland County Public Health Center, 2020). Community education was identified as a potential solution to decreasing the number of community members affected by cerebrovascular disease and resulting death and disability. Five community classes were taught with 97 participants. Pre-, post-, and 1-week post-class surveys were distributed to assess baseline knowledge, knowledge gain, and knowledge retention, with 74 pre-class, 72 post-class, and 28 1-week post-class surveys returned. Of these surveys, after exclusionary criteria were used, 40 pre-class, 53 post-class, and 22 …

My World's On Fire, How 'Bout Yours? An Investigation Of How Privilege Fosters And Maintains Climate Denial, Morgan A. Chester

Antioch University Dissertations & Theses

The present study investigates the phenomenon of climate denial through a new theoretical framework of privilege. The analysis utilizes a feminist orientation that builds on a historical interpretation through the lens of colonialism. Through the dissection of current multidisciplinary understandings of climate denial and new concepts discovered in the review of academic literature and popular media, a compilation of theory, relationship, and connection is made. Systems of power and privilege are examined and connected to the mechanisms and maintenance of climate denial. The resulting analysis illuminates that settler colonialism, supported by connected ideologies of White supremacy, ableism, and patriarchy inform …

The Benefits Of Prenatal Education Via Virtual And Mobile Applications Before, During, And After Pregnancy: A Quality Improvement Project, Lindsay Farland

Master's Theses and Capstones

Background: The advancements of technology has led to a substantial increase in the use of pregnancy applications among expecting parents. Studies indicate that a majority of pregnant individuals utilize virtual education platforms for various purposes, including accessing information on nutrition, exercise, baby development, and pregnancy symptoms. Despite the potential benefits, participation in these platforms remains low, emphasizing a need for enhanced resources and engagement strategies. Research shows that engagement with antenatal education through mobile applications can lead to improved maternal and fetal outcomes, such as reduced rates of caesarean births and fewer complications related to hypertension or preeclampsia.

Methods: …

Implementing A Nurse-Driven Protocol To Reduce Routine Gastric Residual Monitoring: A Quality Improvement Project, Alondra N. Abreu Carlo

Master's Theses and Capstones

The American Society for Enteral and Parenteral Nutrition (ASPEN) and the Society for Critical Care Medicine (SCCM) updated the Adult Patient Enteral Nutrition Guidelines in 2016. These updates included discontinuing routine gastric residual monitoring due to its contribution to poor patient outcomes and mentioning the lack of evidence proving its relevance to gastric motility. Per ASPEN and SCCM, best practice suggests monitoring patients for intolerance symptoms and then checking gastric residual volume (GRV) if symptoms are present. If the GRV is greater than 500ml and intolerance symptoms are present, the recommendation is to perform further assessment, potentially leading to stopping …

Educational Interventions To Improve Icu Nurses’ Knowledge And Confidence Related To Pressure Injuries: A Quality Improvement Initiative, Benjamin R. Maltais

Master's Theses and Capstones

Background: The prevalence of pressure injuries (PI) in critical care is highest amongst inpatient units, and are associated with significant complications, decreased quality of life, increased cost of hospitalization, and poor patient care (Agency for Healthcare Research and Quality, 2019; Cox et al., 2022; Gorecki et al., 2014; Mervis & Phillips, 2019). Similarly, many PI are considered to be avoidable (Pittman et al., 2019). Despite an increase in focus on PI awareness and prevention, there still remains a challenge for patients in critical care units. In addition, research has indicated that nurses’ lack of basic knowledge of PI (risk assessment, …

Challenging The Criminalization Of Undocumented Drivers Through A Health-Justice Framework, Jason A. Cade

Scholarly Works

States increasingly use driver’s license laws to further policy objectives unrelated to road safety. This symposium contribution employs a health justice lens to focus on one manifestation of this trend—state schemes that prohibit noncitizen residents from accessing driver’s licenses and then impose criminal sanctions for driving without authorization. Status-based no-license laws not only facilitate legally questionable enforcement of local immigration priorities but also impose structural inequities with long-term health consequences for immigrants and their family members, including US citizen children. Safe, reliable transportation is a significant social determinant of health for individuals, families, and communities. Applying a health justice lens …

Comparative Analysis Of Calcium Oxalate Abundance And Variation Across Parts And Subparts Of Amorphophallus Longispathaceus Engl. & Gehrm. (Araceae), Phil Anthony B. Sumabat, Jaybie S. Arzaga, Nonnatus S. Bautista

Journal Article

This study examines the variation and abundance of calcium oxalate (CaOx) crystals in Amorphophallus longispathaceus Engl. & Gehrm., a species of economic interest known for its acridity due to CaOx crystals. These crystals play key roles in defense and calcium regulation. The study quantifies the abundance, morphology, and length-to-width ratio of raphide bundles across different tissues. Samples from five individuals were analyzed microscopically, revealing diverse CaOx crystal forms, including raphides, styloids, druses, and atypical structures in the lamina, petiole, and corm. Raphide bundles were most abundant in the corm, followed by the lamina and petiole, with significant differences in distribution …

Behavioral Activity Budget Of Grower Beetal Kids Offered Total Mixed Ration Under Stall-Fed System, Priya Dhattarwal, Mandeep Singla, Sandeep Kaswan, Ravinder Singh Grewal, Neeraj Kashyap, Dalpat Singh Malik

Turkish Journal of Veterinary & Animal Sciences

This study investigates the behavioral activities of grower Beetal kids fed in a conventional method-control group manner orgiven total mixed ration (TMR) (i.e. hay-based - T1 and green fodder-based - T2). Twenty-four weaned Beetal kids were enrolled andrandomly distributed into 3 groups based on their body weight, sex, and age. Behavioral observations were recorded 30 min after givingexperimental ration to the kids using the scan sampling method for 1 h, which inferred time spent eating normally, eating with forelegson the cage, and eating with forelegs on the feeders; standing idle and urination were significantly higher in the control group than …

Disrupted One-Carbon Metabolism In Heifers Negatively Affects Their Health And Physiology, Matthew S. Crouse, Ronald J. Trotta, Harvey C. Freetly, Amanda K. Lindholm-Perry, Bryan W. Neville, William T. Oliver, Carrie J. Hammer, Jessica G. Syring, Layla E. King, Tammi L. Neville, Lawrence P. Reynolds, Carl R. Dahlen, Joel S. Caton, Alison K. Ward, Robert A. Cushman

Animal and Food Sciences Faculty Publications

The objective of this study was to determine the dose-dependent response of one-carbon metabolite (OCM: methionine, choline, folate, and vitamin B12) supplementation on heifer dry matter intake on fixed gain, organ mass, hematology, cytokine concentration, pancreatic and jejunal enzyme activity, and muscle hydrogen peroxide production. Angus heifers (n = 30; body weight [BW] = 392.6 ± 12.6 kg) were individually fed and assigned to one of five treatments: 0XNEG: total mixed ration (TMR) and saline injections at days 0 and 7 of the estrous cycle, 0XPOS: TMR, rumen-protected methionine (MET) fed at 0.08% of the diet dry matter, rumen-protected choline …