Digital Commons Network^™

Cellular Metabolism Is A Viable Therapeutic Target For Radiation-Induced Pulmonary Fibrosis, Josly Pierre-Louis Odoom

Theses and Dissertations

Herein, we provide evidence for cellular metabolic reprogramming as a driver of radiation-induced pulmonary fibrosis (RIPF). We are the first to identify a distinct metabolic signature for RIPF in a cohort of patients with radiographic sequela. We also used a RIPF mouse model to detect the metabolic pathways that enrich during pathogenesis. Our previous work highlighted the importance of lactate, a derivative of the glycolysis end-product pyruvate. Consequently, we took a special interest in the effects of radiation on the glycolysis pathway. We learned that radiation accelerates and reprograms glycolysis to an anabolic state in a pyruvate kinase M2 (PKM2)-dependent …

Examining Parent Behavior And Adolescent Outcomes In A Pediatric Obesity Intervention, Madison W. Weinstock

Theses and Dissertations

Pediatric obesity is a major public health concern that affects over 14.4 million children and adolescents in the United States. Multiple short- and long-term health complications are associated with obesity. Therefore, effective treatment methods are needed in order to ameliorate the effects of said complications, particularly among adolescents. This dissertation investigated potential associations between parent eating behaviors and the outcomes of adolescents enrolled in a pediatric weight loss trial (TEENS+; PI: Bean, R21HD084930). The TEENS+ intervention offered a comprehensive behavioral weight intervention for parent-adolescent dyads. Given the well-established importance of parents in the development of an adolescent’s health behavior, this …

Correlates Of Coffee And Energy Drink Use Among Individuals With Severe Alcohol Use Disorder, Enkelejda Ngjelina

Theses and Dissertations

Research on caffeine consumption among college students and young adults has primarily focused on caffeinated energy drinks (EDs) and their combination with alcohol, demonstrating a strong association with heavy and problematic alcohol use. However, little attention has been directed toward older adults. Furthermore, studies have shown that regular ED consumers are more likely to meet the criteria for alcohol dependence compared to their peers. Despite this association, little is known about ED consumption among individuals with Alcohol Use Disorder (AUD), particularly those undergoing treatment, and even less is understood about other caffeine sources such as coffee. This study aimed to …

The Genetic Architecture Of Cervical Change During Pregnancy: From Modeling To Mechanism — Does The Cervix Mediate Maternal Risk For Spontaneous Preterm Birth?, Hope M. Wolf

Theses and Dissertations

This project leverages clinical data and biospecimens from a prospective longitudinal cohort of pregnant women to study the genetic and phenotypic relationships between cervical shortening and the duration of pregnancy. Sonographic cervical length (CL) was measured throughout pregnancy in a cohort of 5,160 Black/African American women in Detroit, Michigan. Maternal DNA samples were sequenced with a next-generation low-pass whole genome platform. The heritability of cervical change during pregnancy and its genetic correlation with gestational age at delivery (GAD) were estimated using Genome-Wide Complex Trait Analysis. These estimates suggest that cervical change is heritable (h²CL = 51%) and highly polygenic trait. …

Effects Of Exergaming On Health And Fitness Outcomes For Students With Disabilities: A Meta-Analysis, Jordan Mauch

Cal Poly Humboldt theses and projects

While research on VR gaming and Exergaming is in its infancy, both are interventions that have demonstrated positive results such as promoting physical activity participation and positive attitudes towards physical activity in children and adolescents. Exergaming has also been shown to be effective in increasing physical activity in children, and children with disabilities may find exergaming to be an enjoyable alternative to traditional physical activity due to increased accessibility and the focus on both gross and fine motor skills. In studies of VR and/or exergaming with participants with cerebral palsy and autism spectrum disorder, researchers reported increases in motor function …

Study Of Scio-Demographic And Medical Issues Related To Tuberculosis In Baghdad, Iraq 2012-2016, Ali Kareem Durib, Loqman Juma Tawfiq, Z.A. Hassan

Hilla University College Journal For Medical Science

Objective: The present study aimed at investigating socio-demographic issues of gender, living place, marital status, education and type of Tuberculosis, and medical issues, such as new smear positive cases, causes, treatment and new pulmonary positive cases in Baghdad City, Iraq for 2012-2016.

Methodology: A descriptive “retrospective” design was employed throughout the present study from the period of November 12^th 2017 to February 13^th 2018 in order to investigate socio-demographic and medical issues related to Tuberculosis. A convenient sample of (11680) registered patients with tuberculosis in Baghdad, Iraq for the period of 2012-2016. These patients were males and females …

Potential Antidiabetic Activity Of Ficus Carica: The Concept Of Antioxidant Properties In A Rat Model, Hawraa Abdul-Jabbar I. Shwayekh, Reyadh H. Al-Mosawi, Alaa Jafear Mahrath

Hilla University College Journal For Medical Science

Background: The benefits associated with a healthy diet can be attributed to higher concentrations of antioxidants found in fruits and vegetables such as flavonoid-polyphenolic compounds, tocopherols, and carotenoids.

Objectives: The aim of the study was to investigate the antioxidant activity of Ficus Carica and the histopathological study in striptozotocin (STZ) induced T2DM in rats and compare the effect of the plant with sitagliptin.

Materials and Methods: Forty apparently healthy male Wister rats weighing between 180 and 250 grams were used in the current investigation, which began in December 2023. To create type 2 diabetes mellitus (T2 DM), rats were fed …

Speech Regulation And Tobacco Harm Reduction, Jonathan H. Adler, Jacob James Rich

Faculty Publications

Part I of this essay describes what is currently understood about the relative health risks of ENDS [electronic nicotine delivery systems] and other vaping products, particularly as compared to combustible cigarettes.

Part II of this essay describes the current regulatory regime governing tobacco products and how this regime has been applied to ENDS and other vaping products.

Part III of this essay explains how the FDA’s regulatory regime hampers the ability of ENDS manufacturers to inform consumers about the relative risks of their products and the potential use of ENDS as smoking cessation aids.

Part IV explains why this regulation …

The Role Of Osaa Gene In Aspergillus Fumigatus Development, Secondary Metabolism And Virulence., Apoorva Dabholkar

Graduate Research Theses & Dissertations

Aspergillus fumigatus is the leading cause of aspergillosis, associated with high mortality rates, particularly in immunocompromised individuals. In search of novel genetic targets against aspergillosis, we studied the WOPR transcription factor OsaA. Deletion of the osaA gene resulted in colony growth reduction. Conidiation is also influenced by osaA; both osaA deletion and overexpression resulted in a decrease in spore production. Wild-type expression levels of osaA are necessary for expression of the conidiation regulatory genes brlA, abaA and wetA. In addition, osaA is necessary for normal cell wall integrity. Furthermore, deletion of osaA resulted in a reduction in the ability of …

Longevity,Feeding Behavior, And Egg Production Of Adult House Flies (Musca Domestica) Provided With Potential Farm Foods, Anna Elise Grimenstein

Graduate Research Theses & Dissertations

House flies (Musca domestica) are cosmopolitan pests to both humans and livestock, and they can vector many diseases. House flies are especially associated with livestock facilities, as adult flies lay eggs in rotting organic matter such as manure. While it is understood that the diet an adult fly receives can affect biological parameters such as longevity and egg production, not much research has been done to address foods that are accessible to house flies in their natural habitat. The present study examined the longevity, feeding behavior, and egg production rates of adult house flies given different foods they would have …

The Energetics Of Seasonality In Wild Diademed Sifaka (Propithecus Diadema): A Technical And Biological Validation Of Fecal Triiodothyronine Radioimmunassay, Casey Farmer

Graduate Research Theses & Dissertations

The energetic state of an animal has vital consequences for its fitness, but it can be difficult to detect through behavioral observations. The development of techniques to determine an animals’ energetic state non-invasively would allow conservation planners to rapidly assess the energy balance and conservation potential of individuals, groups, and populations. Thyroid hormones like triiodothyronine (T3) regulate and reflect metabolic state in mammals. T3 is a non-invasive biomarker that can be detected in feces and could potentially be used for this purpose. I perform the first validation of a commercially available T3 radioimmunoassay designed for humans on a wild strepsirrhine …

Amazing Or Awful? The Role Of Message Frames In Expectancy-Value Based Weight Management Intentions, Xuan Qian

Graduate Research Theses & Dissertations

This study examined the effective message frames in improving individuals’ weight management intentions. Focus on gain-framed and loss-framed messages, their interactions with expectancy and value were unveiled in both weight loss and weight loss maintenance conditions. A 2 (message frames: gain-framed vs. loss-framed) x 2 (weight management: weight loss vs. weight loss maintenance) online experiment (N = 249) was conducted. Participants were asked about their weight management experiences, read manipulated messages, and answered questions about perceived expectancies and values toward future behaviors. Results showed that gain-framed messages are more effective in arousing individuals’ intentions and values in both weight loss …

How Students On A Healthcare Track Value Learning Communication Skills, Christina M. Cline

Graduate Research Theses & Dissertations

Communication is a critical component of effective healthcare. Students interested in going into healthcare fields require training to learn how to effectively communicate. These students have a need to learn communication skills. Understanding students’ value for learning these skills is necessary for increasing the motivation to learn. In this study, a mixed method approach was used to investigate the value that students on a healthcare track had for learning communication skills. Quantitative methods were used to develop a survey measuring student value and then evaluate students’ value when completing a communication skills activity in a gross human anatomy course. Qualitative …

The Expansion Of Social Assistance Programs: The Politics Of Development In Bangladesh, Sumaya Tamanna

Graduate Research Theses & Dissertations

Why do authoritarian regimes in the global south expand social assistance programs when electoral competition is absent? What are the driving factors behind their willingness to adopt and expand pro-poor social assistance programs? To answer this question in the context of Bangladesh, I did a secondary qualitative analysis to unfold the puzzle of social assistance expansion in Bangladesh. I explored existing literature and tested those in the case of Bangladesh by analyzing existing literature on Bangladesh, as well as data and documents in order to solve the puzzle. I find that, even though electoral competition is absent, the current regime …

Are Elaeagnus Umbellata Invasions Limited By Microbial Interactions?, Cody Anderson Leverette

Masters Theses

Mutualistic interactions with soil microbes are a key component of plant invasions. Mutualists such as ectomycorrhizal fungi and Rhizobia bacteria often limit invasive plant establishment and performance, but the role of nitrogen-fixing Frankia bacteria in invasions remains largely unexplored. In this study, I quantified the net effects of positive and negative plant-soil feedbacks, including Frankia nodulation, on invasive Elaeagnus umbellata (autumn olive; hereafter AO) seedling performance and traits at varying distances from focal shrubs using live soil and sterilized soil. The expectation was that seedling performance would decrease with further distance from shrubs as Frankia abundance decreased. Contrary to expectations, …

Exploring A Medicinal Strain Of White-Rot Fungus For Biofuel Applications, Kortney L. Lucius

Masters Theses

The major limitation to producing biofuels from lignocellulosic biomass, such as miscanthus straw, is the difficulty in accessing fermentable carbohydrates encased in lignin. Traditional methods for separating lignin are economically and environmentally costly. Biological pretreatment using white-rot fungi, such as Trametes versicolor, has been demonstrated to potentially reduce the need for harsh chemical and physical pretreatment methods. Despite these efforts, the process of converting lignocellulose to ethanol remains financially challenging. To explore a potential co-product for the process, this study evaluated the efficacy of T. versicolor strain CM-101, known for producing the valuable medicinal macromolecule polysaccharide-K (PSK), as a …

Quisieron Enterrarnos, Pero No Sabían Que Éramos Semillas: The Ayotzinapa 43 And The Historical Legacy Of Las Escuelas Normales Rurales, 1921-2014, Noah A. García

Masters Theses

In September of 2014, forty-three normalistas from the Escuela de Ayotzinapa were forcibly disappeared. While their whereabouts remain unknown, the attacks and subsequential forced disappearances is but one of many attacks the escuela normal rural has faced since its formation in 1926. This thesis traces the development of rural education in the post-revolutionary Mexican State and how its development provides insight into the 2014 forced disappearances. Additionally, I examine how the Escuela de Ayotzinapa’s legacy of a socialist education has historically been opposed. During its early years of operation, this form of education was predominantly challenged by conservatives and Catholics. …

Exploring The Connection: Field Ecology Research And Student Wellbeing, Elizabeth Small

Graduate Research Theses & Dissertations

Field work is essential in ecological research, offering the opportunity to gather firsthand data, observe natural processes, and deepen our understanding of ecosystems. In my study on small mammal trophic niche dynamics, I investigate how small mammals—critical players in grassland food webs—adapt their diets in response to environmental disturbances. By examining the drivers of variation in trophic niche among three common small mammal species, I aim to uncover how these animals coexist despite similar dietary requirements. Understanding these dynamics is critical for informing global conservation efforts, especially as we work to reverse the biodiversity crisis and restore damaged ecosystems.However, the …

Through The Lens Of Tiktok: A New Perspective To Improving Food And Nutrition Literacy In Adolescents, Devin Kathleen Ebeling-Hammond

Graduate Research Theses & Dissertations

Understanding food, nutrition, and physical activity is essential for everyone, and is important to learn from a young age to foster healthy, lifelong habits. Research indicates that 50% of adolescents do not consume the right amount of fruit, vegetables, or protein, and often consume excessive amounts of fats and sugar. Coincidentally, type 2 diabetes and other non-communicable diseases are on the rise, which can be improved through modifiable health determinants. The purpose of this study is to provide insight into innovative ways to teach adolescents about food, nutrition, and the importance of physical activity. An exploratory pilot study was selected …

Examining Project Flex: A Sport-Based Prison Program For Incarcerated Youth, Gabrielle Bennett

Graduate Research Theses & Dissertations

There is a growing global body of literature examining the experiences of adolescents in sport-based youth development programs. Conversely, the advantages of such programming are often contingent on intention, design, population, and environment. One often overlooked setting that serves a vital population benefiting from the integration of sport-based youth development programs, is juvenile justice facilities. Beyond adolescents, much literature remains to be explored in penal settings, particularly, the inception of sport-based prison programs that utilize an evidence-based curriculum and explicit approach to foster life skill development. Often overlooked are staff, administrators, and youth perspectives of sport-based youth development programs in …

Dna Methylation In Aging And Alzheimer's Disease, Raymond Cheng, Jingmin Shu, Hai Chen, Ming Li, Xiaodong Cheng, Li Liu

The Brown Foundation: Institute of Molecular Medicine

DNA methylation undergoes significant changes with age. These alterations play a pivotal role in the development of age-related diseases, including Alzheimer's disease (AD). Recent advancements in DNA methylome profiling have revealed global hypomethylation patterns, particularly within repetitive elements, as well as gene-specific changes that are associated with neurodegeneration. Age-related alterations in DNA methylation have been implicated in the disruption of key cellular processes, such as inflammation and proteostasis, both central to AD pathology. However, several challenges persist in this field. One major issue is the inconsistency of findings across different brain regions and tissue types, which complicates result interpretation. Furthermore, …

Benthic And Epibenthic Invertebrate Assemblages Associated With Estuarine Submerged Aquatic Vegetation Differ Between Native And Invasive Plants, Marissa Hall, Kathryn O'Shaughnessy, Bethany Kiley, Ashley Mcdonald, Taber Faurie, Zoey Hendrickson, Anna Reimer, Samantha Smith, Charles Martin

Gulf and Caribbean Research

Estuarine submerged aquatic vegetation (SAV) provides vital habitat for macroinvertebrate communities that support diverse food webs and subsequent ecosystem services. Invasive SAV, however, has the potential to alter estuarine food webs through competition with native SAV, resulting in different associated biological communities. In the Mobile-Tensaw Delta (Alabama, USA), the invasive Eurasian milfoil, Myriophyllum spicatum, is fast becoming the dominant SAV, out-competing native SAV such as wild celery, Vallisneria americana. This study investigated the above- and belowground macroinvertebrate assemblages associated with these SAV habitats. We found significantly different assemblages between the SAV, with V. americana supporting more even and …

Slow Glycolysis Exercise Responses On The Body When Fueled By Short-Term Differing Carbohydrate Levels, Skylar Gayman

High Impact Practices Student Showcase Fall 2024

Dieting fads have been a fascination across America for many years. “Have you tried the keto diet?” “What about a low carb diet?” But what many people may not know, or consider, is the physiological effects that these may have on the body. Dieting faddists often find themselves in “bad moods” or “irritable”, lacking the energy necessary to maintain physical activity. Weight loss, although necessary for borderline obese and obese populations, has become a hyper fixation of our population. Often leading us to find “quick fixes” to the very simple, yet well-disciplined answer of a healthy diet and exercise to …

Screening For And Addressing Social Determinants Of Health In Hospitals Participating In Accountable Care Organizations, Heather Lee

All ETDs from UAB

There is a growing recognition among hospitals, payers, and policymakers in the United States that addressing social needs of patients is important to improving quality of care, patient outcomes, and lowering health care spending. Accountable care organizations (ACOs) may be especially incentivized to address social needs of patients to meet population health goals related to patient outcomes and costs. This cross-sectional study used data from the American Hospital Association Annual Survey to explore to explore how hospitals participating in or leading ACOs are screening for and addressing individual-level HRSNs of patients and to understand the extent to which ACOs are …

Assessment Of Caretaker Resources And Motivation In The Wean-To-Market Phase Of Swine Production, Joshua W. Holtkamp

Graduate Thesis and Dissertation 2023-2024

This study is a novel application of I/O Psychology principles to the U.S. swine industry. The Swine Health Information Center (SHIC) recently identified caretaker motivation related to compliance with biosecurity behaviors as a priority needing to be better understood. This exploratory study seeks to identify if there is indeed a worker motivation issue within the industry that is impacting compliance with biosecurity, and if so, establish both a baseline of motivation and a better understanding of the primary influencing factors. Using the Theory of Planned Behavior and the Job Demands/Resources Model of Burnout as a framework, an online survey was …

Breaking Cultural And Financial Barriers In Olympic Sports, Maureen A. Weston, Professor Of Law

Vanderbilt Journal of Entertainment & Technology Law

Nelson Mandela has said that “[s]port has the power to change the world. It has the power to inspire. It has the power to unite people in a way that little else does . . . . It is more powerful than governments in breaking down barriers.” Sports can have tremendous value, not only to the individual participants in promoting physical and mental health, skills, and teamwork, but also to society in fostering community, civic pride, and a sense of belonging, even among the fans. Sports have significant economic, political and cultural impacts at the local, national, and international spheres. …

Effects Of Language Differences On Healthcare Barriers Experienced By Arab Americans, Abigail Yazdiya

Honors Undergraduate Theses

This study analyzes the effects of language differences on healthcare services for Arab Americans. The research specifically investigates the subpopulation of ESL (English Second Language)/bilingual Arab Americans, in order to learn about the effect of a lack of interpretation services and therefore the use of family translators on healthcare treatment. There has been a lack of research on this growing population in the United States. Language barriers can hinder the already difficult process of healthcare. These barriers, combined with other barriers, such as cultural factors, can negatively affect healthcare treatment and outcomes. This study uses surveys to reach people in …

Swimming Through Time: Ancient Dna Analysis Of Salmonid Remains At Housepit 54, Bridge River, British Columbia, Canada, Kara K. Fox

Graduate Student Theses, Dissertations, & Professional Papers

The application of ancient DNA (aDNA) analysis on archaeological faunal remains has proven successful in a variety of studies that have resulted in species identification and subsistence use at ancient village sites. Fisher-hunter-gatherer societies of the Pacific Northwest have depended heavily on seasonal salmon runs as a primary staple for foodstuffs and winter storage essentials. Determining which salmonid species were chosen provides a better understanding of ancient socio-economic strategies that impact food procurement and varying preferences of food items that can lead to resource access limitations. Ultimately, this thesis is a preliminary research project to establish the groundwork for successfully …

Understanding Disparities In Hypertension Treatment Cascade And Validating Blood Pressure Measurement Among Persons Living With Or At Risk For Hiv, Jessica Blair

All ETDs from UAB

In the United States, 44% of adult women >18 years have hypertension. Although non-Hispanic Black adults were more likely to be aware of and treated for hypertension compared to non-Hispanic White adults, Black individuals had the highest prevalence of uncontrolled hypertension. Persons living with HIV have a higher prevalence of hypertension, which is a major modifiable risk factor for cardiovascular disease. Similar to the geographic distribution of hypertension in the US, people living in the South have higher incidence of both hypertension and HIV diagnoses compared to other US regions. Furthermore, accurate diagnosis of hypertension and initiation of treatment is …

Exploring The Epitranscriptomic Response To Senolytics And Senomorphs In Cellular Models Of Aging, Emily Benson

Electronic Theses & Dissertations (2024 - present)

In senescence that occurs with aging, cells stop dividing and initiate a pro-inflammatory program called the senescence associated secretory phenotype (SASP). SASP can lead to cell damage and has been linked to age-related conditions such as cancer, diabetes, osteoporosis, cardiovascular disease, Alzheimer’s disease, and osteoarthritis. The epitranscriptome regulates translation through post-transcriptional RNA modifications and can control when and how much of protein synthesis occurs. Several tRNA modifications that include 5-methoxycarbonylmethyl (mcm⁵U), 5-methoxycarbonylmethyl-2-thiouridine (mcm⁵s²U), and mcm⁵Um (5-methoxycarbonylmethyl-2′-O-methyluridine) are linked to the translation of enzymes involved in the detoxification of reactive oxygen species (ROS), …